CURRICULUM VITAE NICOLE PROBST-HENSCH
http://www.swisstph.ch/no_cache/about-us/staff/detail-single-all/staff/71/nicole-probst-hensch/Probst.html
Personal Information
Name in Full:
Nicole Probst-Hensch, Dr.phil.II & Ph.D., Professor of Public Health (Extraordinaria)
Business Address:
Swiss Tropical and Public Health Institute
Socinstrasse 57, P.O.Box, 4002 Basel, Switzerland
Business Phone:
++41 61 284 83 88
FAX:
++41 61 284 81 05
Email:
Nicole.Probst@unibas.ch
Home Address:
Ob. Rebbergweg 44, 4153 Reinach, Switzerland
Education
1980
1980-1985
1991
1993
1995
High School/College Kantonsschule Kreuzlingen, Matura Typus B
ETH Zürich, School of Pharmacy
University of Basel, School of Pharmacy
University of California, Los Angeles, MPH
University of California, Los Angeles, PhD Epidemiology
Positions and Employment
1990-1991
Research Assistant, University of Basel
1994
Research Assistant, University of California Los Angeles, USA
1994
Postdoctoral Fellow, University of California, Los Angeles, USA
1994-1995
Postdoctoral Fellow, University of Southern California, Los Angeles, USA
1995-1997
Research Assistant Professor, University of Southern California, Los Angeles, USA
1997-2002
Head, Department of Cancer Epidemiology and Molecular Epidemiology &
2002-2008
Head, Zürich Cancer Registry and Dept. Molecular Epidemiology, University of Zürich
Member Board of Directors, Institute of Social and Preventive Medicine, University of Zürich
2004
Habilitation, School of Medicine, University of Zürich
2008
Associate Professor (Titularprofessor), School of Medicine, University of Zürich
2008-2009
Director, National Institute of Cancer Epidemiology and Registration, University of Zürich &
Head, Department of Chronic Disease Epidemiology, University of Zürich
Member Board of Directors, Institute of Social and Preventive Medicine, University of Zürich
2009
Full Professor (Extraordinaria), School of Medicine, University of Basel
2009Head, Unit Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute
Other Experience, Professional Memberships and Scientific Consultancies
1998Scientific Advisory Committee, Cancer Prevention Programs, Swiss Cancer League
1998Faculty, Interuniversity Postgraduate Training Program in Public Health, Switzerland
2002Head Biobank/Genetics & Member Steering Committee SAPALDIA
2002-2005
Member, Committee on Human Rights, Council of the Swiss Scientific Academies
2003Member, Foundation Council Biobank Suisse
2007Member, Federal Expert Committee, Law on Genetic Testing in Humans
2007President, Scientific Committee, Swiss Public Health
2010Head, Task Force Biobanking, Swiss TPH and University of Basel
2010Founding Member, Public Health Genomics Task Force Switzerland
2012Member, Air Quality Board, Switzerland
2012Member, Scientific Committee, Swiss Lung League
2013Member, Expert Committee Personalized Medicine, Swiss Academy Medical Science
Society Memberships: American Association Cancer Research (AACR); Swiss Public Health; Society for Epidemologic
Research (SER); European Respiratory Society (ERS)
Journal Memberships: Public Health Genomics (Editorial Board); Environmental Health Perspectives (Editorial
Review Board)
Research Support
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National Cancer Institute, US:Gene-Environment Interactions in Colorectal Polyps.1994-1999, Graduate Student
Researcher GSRII 654’859 USD
National Cancer Institute, US:Sigmoidoscopy-Based Case-Control Study of Polyps.Co-Investigator, 1995-1999 2’480’367
USD
Breast Cancer Research Program, University of California, US:Genetic Variants of Aromatase in Breast Cancer
IDEA Grant 2IB-0019 Principal Investigator, 1996-1997 81’820 USD
National Institutes of Health, US:Cruciferous vegetables, genes and colon adenomas Co-Investigator, 1996-2000
399’585USD
Swiss National Science Foundation:Aromatase and Breast Cancer Risk,Prosper Fellowship,Principal nvestigator, 1999-2001
686’000 CHF
Breast Cancer Research Program,University of California, US:IGF system and Breast Cancer Risk in Postmenopausal Women
Consultant, 1999-2001 120’000 USD
Department of Defense, US:Genetic determinants of aromatase expression& susceptibility to post-menopausal breast
Cancer (BC981193;PI: S.A. Ingles) Consultant, 1999-2002 252’391
USD
Freiwillige Akademische Gesellschaft Basel:Genetic Markers and Respiratory Disease Principal Investigator, 2001-2004
137’000 CHF
National Institutes of Health, US:Genetic Susceptibility to Cancer in Multiethnic Cohorts CA63464B (PI: BE.Henderson) CoInvestigator, 2000-2002 4’041’136 USD
Swiss National Science Foundation/various funding sources: The SAPALDIA II Cohort Study: Impact of Environmental and
personal risk factors on the occurrence, course, remission and progression of respiratory diseases in the Swiss population
Co-Investigator, 2002-2003 4’500’500 CHF
Center for Technology Assessement , Swiss Council for Technology Assessment: Pharmacogenomics. Co-Investigator, 2002
99’500 CHF
Lungenliga Kanton Zürich: Luftschadstoffe, Rauchen, oxidativer Stresshaushalt, genetische Prädisposition und
Lungenfunktion (SAPALDIA) Principal Investigator, 2004 107'580 CHF
Olga Mayenfisch Stiftung: Association between plasma alpha-1-antitrypsin Concentrations and 11-year course of lung
function among adult smokers in the SAPALDIA cohort,Principle Investigator, 2004 50'000 CHF
European Alpha-1 Antitrypsin Laurell’s Training Award (ALTA Award) Mentor for Trainee (Dr.med. Oliver Senn), 2004
90’000 CHF
Lungenliga Kanton Zürich: a1-antitrypsin and lung function among smokers in the SAPALDIA Cohort.Principle Investigator,
2005 25’000 CHF
Swiss National Science Foundation: Cyclin D1 and beast cancer in the Singapore Cohort Mentor, Ausbildungsstipendium Dr.
med. M. Ceschi, 2004 20'000 CHF
Krebsliga Kanton Zürich 2004, Cyclin D1 and breast cancer in the Singapore Cohort Mentor, Ausbildungsstipendium Dr.
med. M. Ceschi, 2004 15'000 CHF
UBS Wealth Planning: Oxidativer Stress Reflex: Genetische Variabilität im Hämoxygenase-Gen, Herzrhythmusvariabilität
und Lungenfunktion Principal Investigator, 2006
85’810 CHF
Swiss National Science Foundation: Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults (SAPALDIA)
Co-Investigator, 2006-20011 8'092'601 CHF
Georg und Bertha Schwyzer-Winiker Stiftung:“Influence of the Lipoxygenase Pathways in Lung Function and Asthma:
Genetic approach in SAPALDIA” Co-Principal-Investigator,2007 118'000 CHF
Swiss Cancer: Patterns of Care in Breast Cancer Patients in Switzerland Co-Investigator, 2006 259’500 CHF
6th Framework Programme, Integrated Project: GABRIEL (Multidisciplinary Study to IdentifyThe Genetic and Environmental
Causes of Asthma In the European Community), Co-Investigator, 2006-, genotyping funds~800’000 Euro
Swiss National Science Foundation ProDoc Gene-Environment Interactions in CODP, SAPALDIAPrincipal Investigator, 20082011 130’000 CHF
Federal Subsidies attracted for Cancer Registry Zürich, 2002-2008, ~700’000 CHF
Coordinating Center of National Institute for Cancer Epidemiology and Registration NICER established at the University of
Zürich Funds (Federal/Foundation money) attracted for the period 2008-2011 2’464’000
CHF
Swiss National Science Foundation: Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults (SAPALDIA)
Co-Investigator, 2009-2011
6’000’000 CHF
Swiss National Science Foundation: Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA)
Co-Investigator, 2011-2014 5'526'265 CHF
Talecris Biotherapeutics GmbH SERPINA1 Haplotypes and Risk for the COPD in the General Population Co-Principal
Investigator, 2009-2011 175’000 Euro
Swiss National Science Foundation Airflow obstruction in non-smoking women: the role of air pollution and codeterminants in two longitudinal studies in Switzerland and Germany Co-Investigator, 2010-2013
250’000 CHF
PUBLICATION LIST – SINCE 2008
Peer-reviewed publications (publications of relevance to this proposal are highlighted in grey)
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Polesel J, Clifford GM, Rickenbach M, Dal Maso L, Battegay M, Bouchardy C, Furrer H, Hasse B, Levi F,
Probst-Hensch NM, Schmid P, Franceschi S. Swiss HIV Cohort Study. Non-Hodgkin lymphoma incidence in
the Swiss HIV Cohort Study before and after Highly Active Antiretroviral Therapy. AIDS 2008;22:301-306.
Imboden M, Brutsche M, Rochat T, Berger W, Probst-Hensch NM. Glutathione-S transferase genotype
increases the bronchial hyperresponsiveness effect on incident asthma risk in adults. The SAPALDIA
cohort. Thorax, 2008;63(4):322-8
Tinguely M, Jenni B, Knights A, Lopes B, Korol D, Rousson V, Curioni Fontecedro A, Cogliatti S, Schmid U,
Dommann-Scherrer C, Maurer R, Renner C, Probst-Hensch NM, Moch H, Knuth A, Zippelius A. MAGEC1/CT7 expression in plasma cell myeloma: sub-cellular localizatioin impacts on clinical outcome. Cancer
Sci 2008;99:720-725.
Opitz I, Soltermann A, Abaecherli M, Hinterberger M, Probst-Hensch N, Stahel R, Moch H, Weder W. PTEN
expression is a strong predictor of survival in mesothelioma patients. Eur J Cardiothorac Surg.
2008;33(3):502-6.
Wong HL, Koh WP, Probst-Hensch NM, Yu MC, Ingles SA. Insulin-like growth factor 1 promoter
polymorphism and colorectal cancer: a functional genomic approach. Gut, 2008;57:1090-1096.
Castro Giner F, Kogevinas M, Mächler M, de Cid R, van Steen K, Imboden M, Schindler C, Berger W,
Franklin KA, Janson C, Jarvis D, Omenaas E, Burney P, Rochat T, Estivill X, Antó JM, Wjst M, Probst-Hensch
NM. TNA-308 in two international population-based cohorts shows increased risk for asthma. Eur Respir J,
2008. Ahead of print.
Senn O , Russi EW , Schindler C, Imboden M, von Eckardstein A, Brändli O, Zemp E, Ackermann-Liebrich U,
Berger W, Rochat T, Luisetti M, Probst-Hensch NM. Circulating Alpha1-Antitrypsin in the General
Population: Determinants and Association with Lung Function. Respir Res 2008;9:35
Zorzetto M, Russi E, Senn O, Imboden M, Ferrarotti I, Tinelli C, Campo I, Ottaviani S, Scabini R, von
Eckardstein A, Berger W, Brändli O, Rochat T, Luisetti M, Probst-Hensch NM. SERPINA 1 gene variants in
individuals from the general population with reduced alpha1-antitrypsin concentrations. Clin Chem
2008;54:1331-1338.
Brideveaux PO, Gerbase MW, Probst-Hensch NM, Schindler C, Gaspoz JM, Rochat T. COPD: Long term lung
function decline, utilization of care and quality of life in modified GOLD stage 1. Thorax 2008;63:768-774.
Mertz KD, Demichelis F, Sboner A, Hirsch MS, Cin PD, Struckmann K, Storz M, Scherrer S, Schmid DM,
Strebel RT, Probst-Hensch NM, Gerstein M, Moch H, Rubin MA. Association of cytokeratin 7 and 19
expression with genomic stability and favourable prognosis in clear cell renal cell cancer. Int J Cancer
2008;123(3):569-576.
Umbehr M, Kessler TM, Sulser T, Kristiansen G, Probst N, Steurer J, Bachmann LM. ProCOC: the prostate
cancer outcomes cohort study. BMC Urol 2008;8(1):9.
Felber Dietrich D, Ackermann-Liebrich U, Schindler C, Barthélémy J-C, Brändli O, Gold DR, Knoepfli B,
Probst-Hensch NM, Roche F, Tschopp J-M, von Eckardstein A, Gaspoz J-M. Effect of physical activity on
heart rate variability in normal weight, overweight and obese subjects: results from the SAPALDIA study.
European J Applied Physiol, 2008;104:557-565.
Felber Dietrich D, Gemperli A, Gaspoz J-M, Schindler C, Liu L.-J. S., Gold DR, Schwartz J, Rochat T,
Barthélémy J-C, Pons M, Roche F, Probst-Hensch NM, Brideveaux P-O, Gerbase MW, Neu U, AckermannLiebrich U. Differences in heart rate variability associated with long-term exposure to NO2. Environ Health
Perspectives 2008;116:1357-1361.
Probst-Hensch NM, Imboden M, Felber Dietrich D, Barthélemy J-C, Ackermann-Liebrich U, Berger W,
Gaspoz J-M, Schwartz J. Glutatione S-Transferase polymorphisms, passive smoking, and heart rate
variability in non-smokers. Environ Health Perspectives 2008;116:1494-9
Clifford GM, Rickenbach M, Polesel J, Dal Maso L, Steffen I, Ledergerber B, Rauch A, Probst-Hensch NM,
Bouchardy C, Levi F, Franceschi S, and the Swiss HIV Cohort Study. Influence of HIV-related
immunodeficiency on the risk of hepatocellular carcinoma. AIDS 2008;22:2135-2141.
Dratva J, Gómez Real F, Schindler C, Ackermann-Liebrich U, Gerbase MW, Probst-Hensch NM, Svanes C,
Omenaas ER, Neukirch F, Wjst M, Morabia A, Jarvis D, Leynaert B, Zemp E. Is age at menopause increasing
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across Europe? Results on age at menopause and determinants from two population-based studies.
Menopause 2009; 16(2):385-9.
Soltermann A, Tischler V, Arbogast S, Braun J, Probst-Hensch N, Weder W, Moch H, Kristiansen G.
Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelia transition protein
expression in non-small lung cancer. Clin Cancer Res 2008;14(22):7430-7437.
Castro-Giner F, Kogevinas M, Imboden M, de Cid R, Jarvis D, Mächler M, Berger W, Burney P, Franklin KA,
Gonzalez JR, Heinrich J, Janson C, Omenaas E, Pin I, Rochat T, Sunyer J, Wjst M, Anto J-M, Estivill X, ProbstHensch NM. Joint effect of obesity and TNF variability on asthma: two international cohort studies. Eur
Resp J 2009;33:1003-9
Riener M-O, Fritzsche F, Clavien P-A, Pestalozzi PC, Probst-Hensch N, Jochum W, Kristiansen G. IMP3
expression in lesions of the biliary tract: a marker for high-grade dysplasia and an independent prognostic
factor in bile duct carcinomas. Hum Pathol. 2009; 40(10):1377-83.
Bridevaux PO, Gerbase MW, Schindler C, Felber Dietrich D, Curjuric I, Dratva J, Ackermann-Liebrich U,
Probst-Hensch NM, Gaspoz JM, Rochat T. Sex-specific effect of body weight on systemic inflammation in
subjects with COPD. Results from the SAPALDIA Cohort Study 2. Eur Respir J, 2009;34:332-9.
Ackermann-Liebrich U, Schindler C, Frei P, Probst-Hensch NM, Imboden M, Gemperli A, Rochat T, SchmidGrendelmeier P, Bircher AJ. Sensitisation to Ambrosia in Switzerland: a public health threat on the wait.
Swiss Med Wkly 2009;139:70-5
Imboden I, Schwartz J, Schindler C, Curjuric I, Berger W, Liu SLJ, Russi EW, Ackermann-Liebrich U, Rochat T,
Probst-Hensch NM. Improved PM10 exposure attenuates age-related lung function decline: genetic
variants in p53, p21 and CCND1 modify this effect. Environ Health Perspect 2009,;117(9):1420-7
Riener MO, Stenner F, Liewen H, Soll C, Breitenstein S, Pestalozzi BC, Samaras P, Probst-Hensch NM,
Hellerbrand C, Müllhaupt B, Clavien PA, Bahra M, Neuhaus P, Wild P, Fritzsche F, Moch H, Jochum W,
Kristiansen G. Golgi phosphorprotein 2 (GOLPH2) expression in liver tumors and ist values as a serum
marker in hepatocellular carcinoma. Hepatology 2009;49:1602-9
Albinger-Hegyi A, Stoeckli SJ, Schmid S, Storz M, Iotzova G, Probst-Hensch NM, Rehrauer H, Tinguely M,
Moch H, Hegyi I. Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph
node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC). Int J Cancer
2010;126(11):2653-62.
Leuenberger M, Frigerio S, Wild PJ, Noetzli F, Korol D, Zimmermann DR, Gengeler C, Probst-Hensch NM,
Moch H, Tinguely M. AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma
is associated with poor prognosis and complex genetic alterations. Mod Pathol 2010;23(2):17786.
Curjuric I, Imboden M, Schindler C, Downs SH, Hersberger M, Liu SL, Matyas G, W Russi E, Schwartz J, Thun
GA, Postma DS, Rochat T, Probst-Hensch NM; the SAPALDIA team. HMOX1 and GST variants modify
attenuation of FEF25-75-decline due to PM10 reduction. Eur Respir J. 2010;35:505-14
Probst-Hensch NM*, Curjuric I*, Bridevaux PO, Ackermann-Liebrich UA, Bettschart RW, Brändli O, Brutsche
M, Burdet L, Gerbase MW, Knöpfli B, Künzli N, Pons MG, Schindler C, Tschopp JM, Rochat T, Russi EW.
Longitudinal Change of Pre-Bronchodilator Spirometric Obstruction and Health Outcomes -Results from
the Sapaldia Cohort. Thorax 2010;65(2):150-6.
*
authors contributed equally
Bordoni A, Probst-Hensch NM, Mazzucchelli L, Spitale A. Assessment of breast cancer opportunistic
screening by clinicopathological indicators: a population-based study. Br J Cancer 2009;101(11):1925-31.
Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V,
Huffman JE, Igl W, Albrecht E, Deloukas P, Henderson J, Granell R, McArdle WL, Rudnicka AR; Wellcome
Trust Case Control Consortium, Barroso I, Loos RJ, Wareham NJ, Mustelin L, Rantanen T, Surakka I,
Imboden M, Wichmann HE, Grkovic I, Jankovic S, Zgaga L, Hartikainen AL, Peltonen L, Gyllensten U,
Johansson A, Zaboli G, Campbell H, Wild SH, Wilson JF, Gläser S, Homuth G, Völzke H, Mangino M, Soranzo
N, Spector TD, Polasek O, Rudan I, Wright AF, Heliövaara M, Ripatti S, Pouta A, Naluai AT, Olin AC, Torén K,
Cooper MN, James AL, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Smith GD, Ebrahim S,
McKeever TM, Pavord ID, MacLeod AK, Morris AD, Porteous DJ, Cooper C, Dennison E, Shaheen S, Karrasch
S, Schnabel E, Schulz H, Grallert H, Bouatia-Naji N, Delplanque J, Froguel P, Blakey JD; NSHD Respiratory
Study Team, Britton JR, Morris RW, Holloway JW, Lawlor DA, Hui J, Nyberg F, Jarvelin MR, Jackson C,
Kähönen M, Kaprio J, Probst-Hensch NM, Koch B, Hayward C, Evans DM, Elliott P, Strachan DP, Hall IP,
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Tobin MD. Genome-wide association study identifies five loci associated with lung function. Nat Genet.
2010;42(1):36-44.
Eichholzer M, Bovey F, Jordan P, Probst-Hensch N, Stoffel-Kurt N. Data on overweight and nutrition in the
2007 Swiss Health Survey. Praxis 2010;99:17-25.
Probst-Hensch NM*, Steiner JHB*, Schraml P, Varga Z, Zürrer-Härdi U, Storz M, Korol D, Fehr MK, Fink D,
Pestalozzi BC, Lütolf UM, Theurillat JP, Moch H. IGFBP2 and IGFBP3 protein expressions in human breast
cancer: association with hormonal factors and obesity. Clin Cancer Res 2010;16:1025-32.
*
authors contributed equally
Adam M, Weid NV, Michel G, Zwahlen M, Lutz JM, Probst-Hensch N, Niggli F, Kuehni C; the Swiss Pediatric
Oncology Group (SPOG) and the Swiss Association of Cancer Registries (ASRT). Access to specialized
pediatric cancer care in Switzerland. Pediatr Blood Cancer 2010;54(5):721-7
Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV,
O’Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang S-J, Johnson AD, Dehghan A, Teumer A,
Paré G, Atkinson EJ, Zeller T, Lohmann K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A,
Hayward C, Aspelund T, Eiriksdottir G, Launer L, Harris TB, Rapmersaud E, Mitchell BD, Boerwinkle E,
Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer I, Haritunias T, Lumley T, Siscovick D,
Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner S, Schillert A, Ziegler A,
Wild PS, Schnabel RB, Wilde BA S, Muenzel TF, Leak LS, Illig T, Klopp N, Meisinger C, Wichmann H-E,Koenig
W, Zgaga L, Zemunik T, Kolcic I,Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell
H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M,
Nitsch D, Brandstätter Kollerits B, Kedenko L, Mägi R, Stumvoll M,Kovacs P, Boban M, Campbell S, Endlich
K, Völzke H, Kroemer HK, Nauck M,Völker U, Polasek O, Vitart V, Badola S,Parker AN, Ridker PM, Kardia
SLR, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason
V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Krämer BK, Rudan I,
Gyllensten U,Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM,
Fox CS. New loci associated with kidney function and chronic kidney disease. Nat Genet 2010;42:376-384.
Pierre-Olivier Bridevaux*, Nicole M. Probst-Hensch*, Christian Schindler, Ivan Curjuric, Denise Felber
Dietrich, Otto Braendli, Martin Brutsche, Luc Burdet, Martin Frey, Margaret W Gerbase, Ursula
Ackermann-Liebrich, Marco Pons, Jean-Marie Tschopp, Thierry Rochat, Erich W Russi.Prevalence of Airflow
Obstruction in Smokers and Never Smokers in Switzerland. Results from the SAPALDIA Cohort Study. Eur
Resp J 2010, in press. *contributed equally to the study
Riener MO, Fritzsche FR, Soll C, Pestalozzi BC, Probst-Hensch N, Clavien PA, Jochum W, Soltermann A,
Moch H, Kristiansen G. Expression of the extracellular matrix protein periostin in liver tumours and bile
duct carcinomas. Histopathology 2010;56(5):600-606.
Riener MO, Vogetseder A, Pestalozzi BC, Clavien PA, Probst-Hensch N, Kristiansen G, Jochum W. Cell
adhesion molecules P-cadherin and CD24 are markers for carcinoma and dysplasia in the biliary tract.
Hum Pathol 2010, Epub
Moffatt MS et al. (co-authorship: Probst-Hensch N). A GABRIEL consortium large-scale genome-wide
association study of asthma. N Engl J Med., in press
Probst-Hensch NM, Curjuric I, Bridevaux PO, Künzli N, Schindler C, Rochat T. Author’s response.Thorax.
2010 Sep 25. [Epub ahead of print]
Hersberger M, Thun GA, Imboden M, Brandstätter A, Waechter V, Summerer M, Schmid-Grendelmeier P,
Bircher A, Rohrer L, Berger W, Russi EW, Rochat T, Kronenberg F, Probst-Hensch N. Association of STR
polymorphisms in CMA1 and IL-4 with asthma and atopy: the SAPALDIA cohort. Hum Immunol. 2010
Nov;71(11):1154-60.
Ess S, Joerger M, Frick H, Probst-Hensch N, Vlastos G, Rageth C, Lütolf U, Savidan A, Thürlimann B.
Predictors of state-of-the-art management of early breast cancer in Switzerland.Ann Oncol. 2011
Mar;22(3):618-24.
Probst-Hensch, N. M., Curjuric, I., Bridevaux, P. O., Künzli, N., Schindler, C., and Rochat, T. (epub ahead of
print) Authors' response. Thorax. Impact factor: 7.041
Gerbase MW, Keidel D, Imboden M, Gemperli A, Bircher A, Schmid-Grendelmeier P, Bridevaux P-O, Berger
W, Schindler C, Rochat T, Probst-Hensch NM. Effect modification of IgE-mediated atopy and rhinitis by GST
genotypes in passive smokers. Clin Exp Allergy. 2011 Nov;41(11):1579-86. Impact factor: 4.084
43. Obeidat M, Wain LV, Shrine N, Kalsheker N, Artigas MS, Repapi E, Burton PR, Johnson T, Ramasamy A,
Zhao JH, Zhai G, Huffman JE, Vitart V, Albrecht E, Igl W, Hartikainen AL, Pouta A, Cadby G, Hui J, Palmer LJ,
Hadley D, McArdle WL, Rudnicka AR, Barroso I, Loos RJ, Wareham NJ, Mangino M, Soranzo N, Spector TD,
Gläser S, Homuth G, Völzke H, Deloukas P, Granell R, Henderson J, Grkovic I, Jankovic S, Zgaga L, Polašek O,
Rudan I, Wright AF, Campbell H, Wild SH, Wilson JF, Heinrich J, Imboden M, Probst-Hensch NM, Gyllensten
U, Johansson A, Zaboli G, Mustelin L, Rantanen T, Surakka I, Kaprio J, Jarvelin MR, Hayward C, Evans DM,
Koch B, Musk AW, Elliott P, Strachan DP, Tobin MD, Sayers I, Hall IP, Consortium S. A Comprehensive
Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample. PLoS
One. 2011;6(5):e19382. Epub 2011 May 20. Impact factor: 4.351
44. Butsch R, Lukas Waelti S, Schaerer S, Braun J, Korol D, Probst-Hensch N, Moch H, Kurrer M. Intratumoral
plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma. Leuk
Lymphoma. 2011 Jul;52(7):1230-8. Impact factor: 2.397
45. Syurina EV, Brankovic I, Probst-Hensch N, Brand A. Genome-based health literacy: a new challenge for
public health genomics. Public Health Genomics 2011;14(4-5):201-210. Impact factor: 3.049
46. Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE,
Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC,
Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger
C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliovaara M,
Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer
LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban
M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S,
Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry
A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I,
Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring
SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk
JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD,
McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietilainen KH, Pin I, Pola Sbreve
EO, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H,
Shin SY, Spector TD, Surakka I, Vitart V, Volzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH,
Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM,
Lawlor DA, Morris RW, Probst-Hensch N, Kaprio J, Wilson JF, Hayward C, Kahonen M, Heinrich J, Musk AW,
Jarvis DL, Glaser S, Jarvelin MR, Ch Stricker BH, Elliott P, O'Connor GT, Strachan DP, London SJ, Hall IP,
Gudnason V & Tobin MD (2011) Genome-wide association and large-scale follow up identifies 16 new loci
influencing lung function. Nat Genet 43, 1082-1090.
47. Brand, A. & Probst-Hensch, N. 2011. Public health and biobanking - the role of public health genomics. Clin
Chem Lab Med 49(Special Suppl.), S57p
48. Probst-Hensch N, Tanner M, Kessler C, Burri C & Künzli N (2011) Prevention: a cost-effective way to fight
the non-communicable disease epidemic. Swiss Med Wkly 141, w13266
49. Joerger M, Thürlimann B, Savidan A, Frick H, Bouchardy C, Konzelmann I, Probst-Hensch N & Ess S. A
population-based study on the implementation of treatment recommendations for chemotherapy in early
breast cancer. Clin Breast Cancer 2012 Apr;12(2):102-9.
50. Ramasamy A, Curjuric I, Coin LJ, Kumar A, McArdle WL, Imboden M, Leynaert B, Kogevinas M, SchmidGrendelmeier P, Pekkanen J, Wjst M, Birchder AJ, Sovio U, Rochat T, Hartikainen AL, Balding DJ, Jarvelin
MR, Probst-Hensch N, Strachan DP, Jarvis DL. A genome-wide meta-analysis of genetic variants associated
with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol
2011:128, 996-1005.
51. Paternoster L, Standl M, Chen CM, Ramasamy A, Bønnelykke K, Duijts L, Ferreira MA, Alves AC, Thyssen JP,
Albrecht E, Baurecht H, Feenstra B, Sleiman PM, Hysi P, Warrington NM, Curjuric I, Myhre R, Curtin JA,
Groen-Blokhuis MM, Kerkhof M, Sääf A, Franke A, Ellinghaus D, Fölster-Holst R, Dermitzakis E,
Montgomery SB, Prokisch H, Heim K, Hartikainen AL, Pouta A, Pekkanen J, Blakemore AI, Buxton JL,
Kaakinen M, Duffy DL, Madden PA, Heath AC, Montgomery GW, Thompson PJ, Matheson MC, Le Souëf P;
Australian Asthma Genetics Consortium (AAGC), St Pourcain B, Smith GD, Henderson J, Kemp JP, Timpson
NJ, Deloukas P, Ring SM, Wichmann HE, Müller-Nurasyid M, Novak N, Klopp N, Rodríguez E, McArdle W,
Linneberg A, Menné T, Nohr EA, Hofman A, Uitterlinden AG, van Duijn CM, Rivadeneira F, de Jongste JC,
52.
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van der Valk RJ, Wjst M, Jogi R, Geller F, Boyd HA, Murray JC, Kim C, Mentch F, March M, Mangino M,
Spector TD, Bataille V, Pennell CE, Holt PG, Sly P, Tiesler CM, Thiering E, Illig T, Imboden M, Nystad W,
Simpson A, Hottenga JJ, Postma D, Koppelman GH, Smit HA, Söderhäll C, Chawes B, Kreiner-Møller E,
Bisgaard H, Melén E, Boomsma DI, Custovic A, Jacobsson B, Probst-Hensch NM, Palmer LJ, Glass D,
Hakonarson H, Melbye M, Jarvis DL, Jaddoe VW, Gieger C; Genetics of Overweight Young Adults (GOYA)
Consortium, Strachan DP, Martin NG, Jarvelin MR, Heinrich J, Evans DM, Weidinger S; EArly Genetics &
Lifecourse Epidemiology (EAGLE) Consortium. Meta-analysis of genome-wide association studies identifies
three new risk loci for atopic dermatitis.Nat Genet. 2011 Dec 25;44(2):187-92.
Ferrarotti I, Thun GA, Zorzetto M, Ottaviani S, Imboden M, Schindler C, von Eckardstein A, Rohrer L, Rochat
T, Russi EW, Probst-Hensch NM, Luisetti M. Serum levels and genotype distribution of α1-antitrypsin in
the general population.Thorax. 2012 Mar 16. [Epub ahead of print]
Imboden M, Bouzigon E, Curjuric I, Ramasamy A, Kumar A, Hancock DB, Wilk JB, Vonk JM, Thun GA, Siroux
V, Nadif R, Monier F, Gonzalez JR, Wjst M, Heinrich J, Loehr LR, Franceschini N, North KE, Altmüller J,
Koppelman GH, Guerra S, Kronenberg F, Lathrop M, Moffatt MF, O'Connor GT, Strachan DP, Postma DS,
London SJ, Schindler C, Kogevinas M, Kauffmann F, Jarvis DL, Demenais F, Probst-Hensch NM.Genomewide association study of lung function decline in adults with and without asthma. J Allergy Clin Immunol.
2012 May;129(5):1218-28
Probst-Hensch N, Künzli N.Preventing noncommunicable diseases-beyond lifestyle. Epidemiology. 2012
Mar;23(2):181-3
Pattaro C et al (co-authorship N. Probst-Hensch) Genome-wide association and functional follow-up
reveals new Loci for kidney function. PLoS Genet. 2012;8(3):e1002584
Paternoster, L., Standl, M., Baurecht, H., Ramasamy, A., Bnnelykke, K., Duijts, L., Jarvelin, M., Ferreira, M.,
Wichmann, H. E., Strachan, D., Thyssen, J., Nohr, E., Jarvis, D., Feenstra, B., Sleiman, P., Glass, D., Palmer,
L., Probst-Hensch, N., Jacobsson, B., Curtin, J., Boomsma, D., Koppelmann, G., Sääf, A., Bisgaard, H.,
Heinrich, J., Evans, D. & Weidinger, S. 2012. Meta-analysis of genome-wide association studies on atopic
dermatitis identifies three novel risk loci. Exp Dermatol 21, e3p
Mehta AJ, Miedinger D, Keidel D, Bettschart R, Bircher A, Bridevaux PO, Curjuric I, Kromhout H, Rochat T,
Rothe T, Russi EW, Schikowski T, Schindler C, Schwartz J, Turk A, Vermeulen R, Probst-Hensch N & Künzli N
(2012) Occupational exposure to dusts,gases and fumes and incidence of COPD in SAPALDIA. Am J Respir
Crit Care Med 2012 Jun 15;185(12):1292-1300.
Mehta AJ, Adam M, Schaffner E, Barthélémy JC, Carballo D, Gaspoz JM, Rochat T, Schindler C, Schwartz J,
Zock JP, Künzli N, Probst-Hensch N.Heart Rate Variability in Association with Frequent Use of Household
Sprays and Scented Products in SAPALDIA. Environ Health Perspect. 2012 Jul;120(7):958-64.
Thun GA, Ferrarrotti I, Imbodne M, Rochat T, Gerbase M, Kronenberg F, Bridevaux P-O, Zemp E, Zorzetto
M, Ottaviani S, Russi EW, Luisetti M, Probst-Hensch NM. SERPINA1 PiZ and PiS Heterozygotes and Lung
Function Decline in the SAPALDIA Cohort. PLoS One. 2012;7(8):e42728.
Adam M, Felber Dietrich D, Schaffner E, Carballo D, Barthélémy J-C, Gaspoz J-M, Tsai M-Y, Rapp R, Phuleria
HC, Schindler C, Schwartz J, Künzli N, Probst-Hensch NM. Long-term exposure to traffic-related PM10 and
decreased heart rate variability: is the association restricted to subjects taking ACE inhibitors? Environ Int.
2012 Nov 1;48:9-16
Curjuric I, Imboden M, Nadif R, Kumar A, Schindler C, Haun M, Kronenberg F, Künzli N, Phuleria H, Postma
D, Russi EW, Rochat T, Demenais F, Probst-Hensch NM. Different genes interact with particulate matter
and tobacco smoke exposure in affecting lung function decline in the general population. PLoS One.
2012;7(7):e40175.
Wilk JB*, Shrine NR*, Loehr LR*, Zhao JH*, Manichaikul A*, Lopez LM*, Smith AV*, Heckbert SR,
Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P,
Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen TH, Couper D, Crapo JD, Davies G, Dupuis
J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw KT, Lahousse L,
Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B,
Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T,
Rotter JI, Soler Artigas M, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA,
Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJ, Strachan DP, London SJ,
Boezen HM*, Probst-Hensch N*, Gharib SA*, Hall IP*, O'Connor GT*, Tobin MD*, Stricker BH*. Genome
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Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction. Am J
Respir Crit Care Med. 2012 Jul 26. [Epub ahead of print] * These authors contributed equally to this work.
Wanner M, Martin BW, Meier F, Probst-Hensch N, Kriemler S. Effects of filter choice in GTX3
accelerometer assessments of free-living activity. Med Sci Sports Exerc. 2012 Aug 14
Prendergast B, Coope LT, Crijns H, Falkenstein E, Fölsch U, Halvorsen S, Janssens S, Jokinen E, Kroemer HK,
Lücke A, Murer H, Nagel E, Neyses L, Perk J, Probst-Hensch N, Rietschel ET, Rütten H, Steingen C, Tedgui A,
van Gilst W, Eschenhagen T, Kristensen SD. The German Centre for Cardiovascular Research. Eur Heart J
2012;33(9):1033-1036
Jacquemin B, Schikowski T, Carsin AE, Hansell A, Krämer U, Sunyer J, Probst-Hensch N, Kauffmann F, Künzli
N.The Role of Air Pollution in Adult-Onset Asthma: A Review of the Current Evidence.Semin Respir Crit
Care Med. 2012 Aug 23. [Epub ahead of print]
Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D,
Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT,
Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ,
Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R,
Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S,
Pistis G; CARDIoGRAM Consortium; ICBP Consortium; the CARe Consortium; WTCCC2, Harris TB, Launer LJ,
Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A,
Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T,
Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH,
Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK,
Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG,
Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Stengel B, Ruggiero D,
Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A,
Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo
M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, ProbstHensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick
DS, van Duijn CM, Borecki IB, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A,
Pramstaller PP, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker PM, Parsa A, Bochud M, Heid IM,
Kao WL, Fox CS, Köttgen A. Integration of Genome-Wide Association Studies with Biological Knowledge
Identifies Six Novel Genes Related to Kidney Function. Hum Mol Genet. 2012 Sep 8. [Epub ahead of print]
Conen D, Adam M, Roche F, Barthelemy JC, Felber Dietrich D, Imboden M, Künzli N, von Eckardstein A,
Regenass S, Hornemann T, Rochat T, Gaspoz JM, Probst-Hensch N*, Carballo D*. Premature atrial
contractions in the general population: frequency and risk factors. Circulation. 2012 Nov 6;126(19):2302-8.
*authors contributed equally
Mehta AJ, Schindler C, Perez L, Probst-Hensch N, Schwartz J, Brändl O, Karrer W, Tschopp JM, Rochat T,
Künzli N.Acute respiratory health effects of urban air pollutants in adults with different patterns of
underlying respiratory disease.Swiss Med Wkly. 2012 Oct 9;142:0. doi: 10.4414/smw.2012.13681
Rochat T, Bridevaux PO, Gerbase M, Probst-Hensch N, Künzli N. What is the role of outdoor air pollution in
asthma? Rev Med Suisse. 2012 Nov 21;8(363):2233-6
2. Reviews
1.
2.
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4.
Zwahlen M, Low N, Borisch B, Egger M, Künzli N, Obrist R, Paccaud F, Zybach U, Probst-Hensch NM.
Population based screening - the difficulty of how to do more good than harm and how to achieve that.
Swiss Med Wkly 2010, in press.
Probst-Hensch N. Chronic age-related diseases share risk factors: do they share pathophysiological
mechanisms and why does that matter?. Swiss Medical Wkly 2010, in press.
Brankovic I, Syurina EV, Probst-Hensch N, Brand A. Genome-based health literacy – a new challenge for
public health genomics. Public Health Genomics, 2011, in press
Zemp E, Schikowski T, Dratva J, Schindler C, Probst-Hensch N.Asthma and the menopause: A systematic
review and meta-analysis. Maturitas. 2012;73(3):212-7
3. Monographs, Books, Book Chapters, Other pertinent publications
1.
2.
3.
4.
Heitz Ph.U., Komminoth P., Zimmermann D., Odermatt B., Probst-Hensch NM., Bopp M. Gesundheit –
Krankheit. In: Böcker W, Denk H. Heitz Ph.U (edts). Pathologie, Urban und Fischer 3. Auflage, 2004.
Bouchardy Magnin C, Pury P, Raymond L, Probst-Hensch NM. Krebs. In: Gutzwiller F, Paccaud F (eds.)
Sozial- und Präventivmedizin/Public Health. Verlag Hans Huber, 3. vollständig überarbeitete Auflage, 2007.
Zwahlen M, Schmidlin K, Spörri A, Probst-Hensch NM. Maladies cancéreuses. La santé en Suisse. Rapport
national sur la santé 2008. Observatoire suisse de la santé. Editions Medecine & Hygiène 2008.
Jahn A, Probst-Hensch N. Public Health Genomics. In: Egger M, Razum O (edts.). Public Health. De Gruyter
2012