March 9, 2016
Curriculum Vitae
Michael Flaum, M.D.
Address:
The University of Iowa Carver College of Medicine
Psychiatry Research / MEB
500 Newton Road
Iowa City, Iowa 52242
Telephone: (319) 353-4340
FAX (319) 353-5439
e-mail: michael-flaum@uiowa.edu
Employment and post-graduate training:
’99 – present
Director, Iowa Consortium for Mental Health Services, Training and Research
’01 – ‘02
Mental Health Director, Iowa Department of Corrections
‘95 - present:
Associate Professor of Psychiatry
Co-Director, Mental Health Clinical Research Center,
Department of Psychiatry, University of Iowa, Iowa City, Iowa
‘90 - ‘95:
Assistant Professor of Psychiatry
Clinical Director, Mental Health Clinical Research Center,
Department of Psychiatry, University of Iowa, Iowa City, Iowa
‘88 -’90:
Post-doctoral Fellow in Clinical Neurobiology/Schizophrenia Research
Department of Psychiatry, University of Iowa, Iowa City, Iowa
‘86 - ‘88
Assistant Clinical Professor of Psychiatry
State University of New York, Health Science Center at Brooklyn
Brooklyn, New York
‘85 - ‘86
Chief resident and Clinical Instructor in Psychiatry
New York University Medical Center, New York, New York
‘82 - ‘85
Resident in Psychiatry
New York University Medical Center, New York, New York
Education:
7/78 - 6/82
State University of New York, Health Science Center at Stony Brook
College of Medicine, Stony Brook, New York
Degree: M.D., 6/82
1/76 - 6/78
Columbia University, College of Basic Studies; New York, New York
Degree: B.S., 6/78
Magna Cum Laude, Phi Beta Kappa
1
Michael Flaum, M.D.
Licensure and Certification:
Licensure:
Certification:
Iowa: July, 1988 - Permanent #26692
New York: April, 1989 - Permanent #158020
American Board of Psychiatry and Neurology - April, 1989 #31116
Professional Affiliations:
American Psychiatric Association
Society of Biological Psychiatry
American Academy of Psychiatry and the Law
International Society for Neuroimaging in Psychiatry
Editorial Activities:
Reviewer for: American Journal of Psychiatry, Archives of General Psychiatry,
Biological Psychiatry, Schizophrenia Bulletin, Schizophrenia Research, Psychiatry
Research: Neuroimaging, Journal of Neuropsychiatry and Clinical Neurosciences,
American Journal of Geriatric Psychiatry, Psychological Medicine, Clinical
Thereapeutics
Areas of Research Interest:
Mental Health Services Research in the areas of:
o Implementation of Evidence-Based Practices
o Assertive Community Treatment
o Mental Health / Criminal Justice interface
o Telemedicine in Psychiatry
o Diagnostic and phenomenological assessment methods in clinical and research
settings
Current University Committee Activity:
Member: Internal Review Board – Committee A
Member: Clinical Outcomes and Resource Management (CORM) Advisory Committee
Governmental Activities:
Member: Iowa Medicaid PDL committee; Appointed by the Governor for a 2 year term,
beginning 11/03
Former Member: Mental Health and Developmental Disabilities Commission;
Appointed by the Governor for a 3 year term 4/99; reappointed 4/02; appointment ended
11/02 when Commssion was reconfigured.
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Michael Flaum, M.D.
BIBLIOGRAPHY
A.
Manuscripts published or in press:
1.
Menza M, Easton J, Flaum M, et al: Approaches to the treatment of lithiumresistant mania. Psychiatric Medicine, 6:73-87, 1988.
2.
Andreasen NC, Flaum M, Swayze VW, et al: Positive and negative symptoms in
schizophrenia: A critical reappraisal. Archives of General Psychiatry, 47:615621, 1990.
3.
Flaum M: Neuroleptics and schizophrenia. Iowa Medicine, 80:60-62, 1990.
4.
Andreasen NC, Swayze VW, Flaum M, et al: Ventricular abnormalities in
affective disorder: Clinical and demographic correlates. American Journal of
Psychiatry, 147:893-900, 1990.
5.
Andreasen NC and Flaum M: DSM-IV in progress: Schizophrenia and related
disorders. Hospital and Community Psychiatry, 41: 954-956, 1990.
6.
Flaum M, Arndt SV, and Andreasen NC: The role of gender in studies of
ventricular enlargement in schizophrenia:
A predominantly male effect.
American Journal of Psychiatry, 147: 1327-1332, 1990.
7.
Andreasen NC, Swayze VW, Flaum M, et al: Ventricular enlargement in
schizophrenia evaluated with computed tomographic scanning: Effects of gender,
age, and stage of illness. Archives of General Psychiatry, 47: 1008-1015, 1990.
8.
Nopoulos P, Flaum M, Miller DD: Clozapine induced NMS without rigidity.
Annals of Clinical Psychiatry, 2: 251-254, 1990.
9.
Flaum M, Arndt, SV and Andreasen NC: The reliability of "bizarre" delusions.
Comprehensive Psychiatry, 32:59 - 65, 1991.
10.
Andreasen NC and Flaum M: Schizophrenia: The characteristic symptoms.
Schizophrenia Bulletin, 17:25-49, 1991.
11.
Flaum M and Andreasen NC: Diagnostic criteria for schizophrenia and related
disorders: Options for DSM-IV. Schizophrenia Bulletin , 17:133-142, 1991.
12.
Andreasen NC, Flaum M, and Arndt, SV: The Comprehensive Assessment of
Symptoms and History (CASH): An instrument for assessing psychopathology
and diagnosis. Archives of General Psychiatry, 49:615-623, 1992.
13.
Arndt SV, Tyrrell G, Flaum M and Andreasen NC Comorbidity of substance
abuse and schizophrenia: The role of pre-morbid adjustment. Psychological
Medicine, 22:379-388, 1992.
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Michael Flaum, M.D.
14.
Andreasen NC, Rezai K, Alliger RJ, Swayze VW, Flaum M. et al:
Hypofrontality in neuroleptic-naive patients and in patients with chronic
schizophrenic: Assessment with Xenon-133 SPECT and the Tower of London.
Archives of General Psychiatry, 49: 943-958, 1992.
15.
Flaum M, Andreasen NC and Arndt SV: The Iowa prospective longitudinal
study of recent onset psychoses. Schizophrenia Bulletin, 18:481-490, 1992.
16.
Andreasen NC, Flaum M, Swayze VW, O'Leary DS et al.: Intelligence and brain
structure in normal individuals. American Journal of Psychiatry, 150:130-134,
1993.
17.
Amador XF, Strauss DH, Yale SA, Flaum M, Endicott J, and Gorman JM:
Assessment of insight in psychosis. American Journal of Psychiatry, 150:873879, 1993.
18.
Andreasen NC, Harris G, Cizadlo T, Arndt S, O’Leary DS, Swayze VW, and
Flaum M. Techniques for measuring sulcal/gyral patterns in the brain as
visualized through MR scanning: Brainplot and Brainmap. Proceedings for
National Academy of Sciences, 90:93-97, 1994.
19.
Houlihan DJ, Flaum M, Arnold SE, Keshavan M, Alliger A: Further evidence
for olfactory identification deficits in schizophrenia. Schizophrenia Research,
12:179-182, 1994.
20.
Miller DD, Flaum M, Arndt SV, Fleming F, and NC Andreasen. The effect of
antipsychotic withdrawal on negative symptoms in schizophrenia.
Neuropsychopharmacology, 11:11-20, 1994.
21.
Amador XF, Flaum M, Andreasen NC, Strauss DH, Yale SA, Clark S, and
Gorman JM: Awareness of illness in schizophrenia, schizoaffective and mood
disorders. Archives of General Psychiatry, 51:826-836, 1994.
22.
Andreasen NC, Arndt S, Swayze VS, Cizadlo T, Flaum M, O'Leary DS, Ehrhardt
J, Yuh WTC: Thalamic abnormalities in schizophrenia visualized through
magnetic resonance image averaging. Science, 266:294-298, 1994.
23.
Roy MA, Flaum M, Gupta S, and NC Andreasen. Epidemiological and clinical
correlates of familial and sporadic schizophrenia. Acta Psychiatric Scandinavica,
89: 324-328, 1994.
24.
Andreasen NC, Nopoulos P, Schultz S, Miller DD, Swayze VW, and Flaum M:
Positive and negative symptoms of schizophrenia: Past, present and future. Acta
Psychiatric Scandinavica, 90(Suppl. 384): 51-59, 1994.
25.
Andreasen NC, Flashman L, Flaum M, Arndt S, Swayze VW, O'Leary DS,
Ehrhardt JC, Yuh WTC: Regional brain abnormalities in schizophrenia measured
with magnetic resonance imaging. JAMA, 242: 1763-1769, 1994
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Michael Flaum, M.D.
26.
Flaum M, Andreasen NC, Swayze VW, O’Leary DS, and Alliger RJ: IQ and
brain size in schizophrenia. Psychiatry Research: 53:243-357, 1994
27.
Nopoulos PC, Flashman LA, Hubbard W, Flaum M, Arndt SV, O'Leary DS, and
NC Andreasen. Stability of cognitive functioning early in the course of
schizophrenia. Schizophrenia Research, 14:29-37, 1994.
28.
Strakowski SM, Flaum M, Tohen M: Substance abuse in psychotic disorders:
associations with affective syndromes. Schizophrenia Research, 14:73-81, 1994.
29.
Arndt SV, Tyrrell G, Woolson R, Flaum, M, Andreasen, N.C. Effects of errors in
a multi-center medical study: Preventing misinterpreted data. Journal of
Psychiatry Research, 28:447-459, 1994.
30.
Roy MA, Flaum M, Arndt SV, Crowe RR, and NC Andreasen. Magnetic
resonance imaging in familial vs. sporadic cases of schizophrenia: Psychiatry
Research, 54: 25-36, 1994
31.
Andreasen NC, Arndt SV, Miller, DD, Flaum M, Nopoulos PC: Correlational
studies of the scale for the assessment of negative symptoms (SANS) and the
scale for the assessment of positive symptoms (SAPS): An overview and update.
Psychopathology. 28:7-17, 1995.
32.
McGorry PD, Mihalopoulos C, Henry L, Dakis J, Jackson HJ, Flaum M, Harrigan
S, McKenzie D, Kulkami J, and Karoly R: Spurious Precision: Procedural
validity of diagnostic assessment in psychotic disorders. American Journal of
Psychiatry, 152:220-223, 1995.
33.
Gupta S, Andreasen NC, Arndt S, Flaum M, Schultz SK, Hubbard WC, and
Smith M: Neurological soft signs in neuroleptic-naive and neuroleptic-treated
schizophrenic patients and in normal comparison subjects. American Journal of
Psychiatry, 152:191-196, 1995.
34.
Flaum M, Swayze VW, O’Leary DS, Yuh WTC, Ehrhardt JC, Arndt SV and NC
Andreasen. Effects of diagnosis, laterality and gender on brain morphology in
schizophrenia. American Journal of Psychiatry, 152:704-711, 1995.
35.
Andreasen NC, Arndt SV, Alliger RJ, Miller DD and Flaum M. Symptoms of
schizophrenia: Methods, meanings and mechanisms. Archives of General
Psychiatry, 52:341-351, 1995.
36.
Arndt SV, Andreasen NC, Flaum M, Miller DD and Nopoulos P. A longitudinal
study of symptom dimensions in schizophrenia: Prediction and patterns of
change. Archives of General Psychiatry, 52:352-360, 1995.
37.
Nopoulos PC, Flaum M, Andreasen NC and Swayze VW. Gray matter
heterotopias in schizophrenia. Psychiatry Research: Neuroimaging, 61:11-14,
1995.
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Michael Flaum, M.D.
38.
Flaum M, O'Leary DS, Swayze VW, Miller DD, Arndt S, and Andreasen NC:
Symptom dimensions and brain morphology in schizophrenia and related
psychotic disorders. Journal of Psychiatric Research, 29:261-276, 1995.
39.
Gupta S, Rajaprabhakaran R, Arndt SV, Flaum M, Andreasen NC: Premorbid
adjustment as a predictor of phenomenological and neurobiological indices in
schizophrenia. Schizophrenia Research, 16;189-197, 1995.
40.
Flaum M and NC Andreasen: The reliability of distinguishing "primary" vs.
"secondary" negative symptoms. Comprehensive Psychiatry, 36:421-427, 1995.
41.
Roy MA, Flaum M and NC Andreasen. No difference found between winterand non-winter-born schizophrenic cases. Schizophrenia Research, 17:241-248,
1995
42.
Nopoulos P, Torres I, Flaum M, Andreasen NC, Ehrhardt JC, and WTC Yuh:
Brain Morphology in first episode schizophrenia.
American Journal of
Psychiatry, 152:1721-1723, 1995.
43.
Andreasen NC, Swayze VS, O'Leary DS, Nopoulos P, Cizadlo T, Harris G, Arndt
S, and Flaum M: Abnormalities in midline attentional circuitry in schizophrenia:
Evidence from magnetic resonance and positron emission tomography. European
Neuropsychiatry (Supplement) 37-41, 1995.
44.
Flashman LA, Flaum M, Gupta S, Andreasen NC:
Soft signs and
neuropsychological performance in schizophrenia. American Journal of
Psychiatry, 153:526-532,1996.
45.
Flaum M and SK Schultz. When does amphetamine-induced psychosis become
schizophrenia? American Journal of Psychiatry, 153:812-815, 1996.
46.
Amador XF, Harkavy Friedman J, Kasapis C, Yale SA, Flaum M and JM
Gorman. Suicidal behavior in schizophrenia and its relationship to awareness of
illness. American Journal of Psychiatry, 153:1185-1188, 1996.
47.
Strakowski SM, Flaum M, Amador XF, Bracha HS, Pandurangi AK, Robinson
D, Tohen M: Racial bias and differences in the diagnosis of psychosis.
Schizophrenia Research, 21:117-124, 1996.
48.
Flaum M: Making sense of schizophrenia. Hospital Practice, 31:51-79, 1996
49.
Kirkpatrick B, Amador XF, Flaum M, Yale SA, Gorman JM, Carpenter WT,
Tohen M, Mcglashan T: The deficit syndrome in the DSM-IV Field Trial .1.
Alcohol and other drug abuse. Schizophrenia Research. 20: 69-77, 1996
50.
Flaum M and SK Schultz. The core symptoms of schizophrenia. Annals of
Medicine, 28:525-531, 1996.
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Michael Flaum, M.D.
51.
Nopoulos P, Swayze VW, Flaum M, Yuh WTC, Ehrhardt JC, Arndt SV and NC
Andreasen. Cavum septi pellucidi in normals and patients with schizophrenia as
detected by MRI. Biological Psychiatry, 41:1002-8, 1997
52.
Gupta S, Andreasen NC, Arndt S, Flaum M, Hubbard W, and S Ziebell: The
Iowa longitudinal study of recent onset psychosis: one-year follow-up of first
episode patients. Schizophrenia Research, 23: 1-13, 1997.
53.
Schultz SK, Miller DD, Oliver SE, Arndt S, Flaum M and NC Andreasen: The
life course of schizophrenia: age and symptom dimensions. Schizophrenia
Research, 23: 15-23, 1997.
54.
Andreasen NC, O’Leary DS, Flaum M, Nopoulos P, Watkins GL, Ponto LLB and
R Hichwa: Hypofrontality in schizophrenia: distributed dysfunctional circuits in
neuroleptic-naive patients. Lancet, 349:1730-34, 1997.
55.
Ho BC, Andreasen NC and M. Flaum: Dependence on public financial support
early in the course of schizophrenia. Psychiatric Services, 48, 948-950, 1997.
56.
Arndt S, Gold S, Cizadlo T, Zheng J, Ehrhardt JC and M Flaum: A method to
determine activation thresholds in fMRI paradigms. Psychiatry Research:
Neuroimaging Section, 75: 15-22, 1997.
57.
Andreasen NC, Flaum M, Schultz S, Duzyurek S and D. Miller: Diagnosis,
methodology and subtypes of schizophrenia. Neuropsychobiology, 35:61-63,
1997.
58.
Nopoulos P, Flaum M and NC Andreasen: Brain morphology in schizophrenia:
Sex differences. Am J Psychiatry, 154: 1648-54, 1997.
59.
Flaum M and NC Andreasen: More choices for treating voices. Lancet, 350
(suppl. III): 22, 1997.
60.
Flashman LA, Andreasen NC, Flaum M, and VW Swayze II. Intelligence and
regional brain volumes in normal controls. Intelligence, 25, 149-160, 1998.
61.
Gold S, Christian B, Arndt S, Zeien G, Cizadlo T, Johnson DL, Flaum M and NC
Andreasen: Functional MRI statistical software packages: A comparative
analysis. Human Brain Mapping 6: 73-84, 1998.
62.
Nopoulos P, Flaum M, Arndt S, and NC Andreasen: Morphometry in
schizophrenia revisited: Height and its relationship to premorbid functioning.
Psychological Medicine, 28:655-663, 1998.
63.
Ho BC, Nopoulos P, Flaum M, Arndt S, and NC Andreasen: Two-year outcome
in first-episode schizophrenia: Predictive value of symptoms for quality of life.
American Journal of Psychiatry, 155:1196-1201, 1998.
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Michael Flaum, M.D.
64.
Nopoulos P, Swayze V, Flaum M, Andreasen NC. Incidence of ectopic gray
matter in patients with schizophrenia and healthy control subjects studied with
MRI. Journal of Neuropsychiatry and Clinical Neurosciences. 10(3):351-3, 1998.
65.
Wassink T, Andreasen NC, Nopoulos PN and M Flaum: Cerebellar morphology
as a predictor of symptom and psychosocial outcome in schizophrenia: Biological
Psychiatry, 45:41-48, 1999.
66.
Magnotta VA, Andreasen NC, Schultz SK, Harris G, Cizadlo T, Heckel D,
Nopoulos P and M Flaum: Quantitative in vivo measurement of gyrification in
the human brain: Changes associated with aging. Cerebral Cortex, 9: 1-10, 1999.
67.
Wassink T, Flaum M, Nopoulos PN and NC Andreasen: Prevalence of
depressive symptomatology early in the course of schizophrenia. American
Journal of Psychiatry, 156:315-16, 1999.
68.
Andreasen NC, Nopoulos P, O’Leary DS, Miller DD, Wassink T and M. Flaum:
Defining the phenotype of Schizophrenia: Cognitive dysmetria and its neural
mechanisms. Biological Psychiatry, 46:908-920, 1999
69.
O’Leary DS, Flaum M, Kesler ML, Flashman LA, Arndt S and NC Andreasen:
Cognitive correlates of the negative, disorganized and psychotic symptom
dimensions of schizophrenia.
Journal of Neuropsychiatry and Clinical
Neurosciences, 12:4-15, 2000.
70.
Nopoulos P, Flaum M, O'Leary D, and NC Andreasen: Sexual dimorphism in the
human brain: evaluation of tissue volume, tissue composition and surface
anatomy using magnetic resonance imaging. Psychiatry Research. 98:1-13, 2000
71.
Ho BC, Andreasen NC, Flaum M, Nopoulos P and D Miller: Untreated initial
psychosis: Its relation to quality of life and symptom remission in first-episode
schizophrenia. American Journal of Psychiatry, 157:808-815, 2000
72.
O’Leary DS, Block RI, Flaum M, Schultz SK, Boles-Ponto LL, Watkins GL,
Hurtig RR, Andreasen NC and RD Hichwa: Acute marijuana effects on rCBF and
Cognition: a PET study. NeuroReport, 11:3855-3841, 2000
73.
White T, O’Leary D, Magnotta V, Arndt S, Flaum M, and NC Andreasen:
Anatomic and functional variablility: The effects of filter size in group fMRI data
analysis. Neuroimage, 13:577-588, 2001
74.
Stephan KE, Magnotta VA, White T, Arndt S, Flaum M, O'leary DS, and
NC Andreasen: Effects of olanzapine on cerebellar functional connectivity in
schizophrenia measured by fMRI during a simple motor task Psychological
Medicine, 31:1065-1078, 2001
75.
O’Leary DS, Block RI, Koeppel JA, Flaum M, Schultz SK, Andreasen NC,
Boles-Ponto LL, Watkins G, Hurtig RR and RD Hichwa: Effects of smoking
8
Michael Flaum, M.D.
marijuana on brain perfusion and cognition. Neuropsychopharmacology, 26:802816, 2002
B.
76.
Lund BC, Flaum M, Adam L, and PJ Perry. Psychiatric Prescribing Trends and
Practices in Iowa's Prisons. Psychiatric Services, 2002 53: 1023-1024.
77.
Arndt S. Turvey CL. Flaum M. Older offenders, substance abuse, and treatment.
American Journal of Geriatric Psychiatry. 10(6):733-9, 2002.
78.
Franck N, O'Leary DS, Flaum M, Hichwa RD, Andreasen NC: Cerebral blood
flow changes associated with schneiderian first-rank symptoms in schizophrenia.
The Journal of Neuropsychiatry and Clinical Neurosciences. 14:277-82, 2002.
79.
Chemerinski E, Ho BC, Flaum M, Arndt S, Fleming F, Andreasen NC. Insomnia
As A Predictor For Symptom Worsening Antipsychotic Withdrawal in
Schizophrenia. Comprehensive Psychiatry, 43:393-396, 2002
80.
Ho BC. Andreasen NC. Nopoulos P. Arndt S. Magnotta V. Flaum M. Progressive
structural brain abnormalities and their relationship to clinical outcome: a
longitudinal magnetic resonance imaging study early in schizophrenia. Archives of
General Psychiatry. 60(6):585-94, 2003
81.
Moser DJ, Arndt S, Kanz JE, Benjamin ML, Bayless JD, Reece RL, Paulsen JS
and M.A.Flaum:, Coersion and informed consent in research involving prisoners.
Comprehensive Psychiatry 45:1-9, 2004
Book Chapters:
1.
Andreasen NC, Flaum M, Arndt SV, Alliger RJ, and Swayze VW: Positive and
Negative Symptoms: Assessment and validity. In: Negative vs. Positive
Schizophrenia, Marneros A, Andreasen NC, Tsuang MT, eds. Springer-Verlag,
Berlin/Heidelberg, 1991, pp 28-51.
2.
Andreasen NC, Flaum M, Arndt SV, Alliger RJ, Miller DD, and O'Leary DS:
Positive and negative symptoms and syndromes: Assessment and biological
correlates. In Ferrero FP, Haynal A, Sartorius N (eds.) Schizophrenia and
affective psychosis. Nosology in contemporary psychiatry. John Libbey CIC
s.r.l., 1992, pp. 79-87.
3.
Andreasen NC, Swayze VW, Flaum M, O'Leary DS, Alliger RJ, and G. Cohen:
The neural mechanisms of mental phenomena.
In, N.C Andreasen (ed.),
Schizophrenia: From Mind to Molecule. Washington, D.C: American Psychiatric
Press, Inc. 1994, pp. 49-92.
4.
Andreasen NC and Flaum M: Characteristic symptoms of schizophrenia. In,
Widiger TA, Frances AF, et al (eds.), DSM-IV Sourcebook, Volume 1.
Washington, D.C: American Psychiatric Association, 1994, pp 351-380.
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Michael Flaum, M.D.
5.
Andreasen NC and Flaum M:
The concept of schizophrenia and the
development of DSM-IV. In, Moroji T and Yamamoto K (eds.): The Biology of
Schizophrenia. Developments in Psychiatry, Volume 10. Elsevier, Amsterdam,
1994, pp 3-14.
6.
Flaum M: The diagnosis of Schizophrenia: In Shriqui CL and Nasrallah HA
(eds.) Contemporary Issues in the Treatment of Schizophrenia. Washington, D.C:
American Psychiatric Press, Inc. 1995, pp 83-108.
7.
Andreasen NC and Flaum M: The schizophrenia spectrum: Perspectives from
neuroimaging. In, Marneros A, Andreasen NC, Tsuang MT (eds.). Psychotic
Continuum. Springer-Verlag, Berlin/Heidelberg 1995, pp 91-106.
8.
Andreasen NC and Flaum M: Nosology, phenomenology, and diagnosis. In,
Sacks MH, Sledge WH and Warren C (eds.) Core Readings in Psychiatry: An
Annotated Guide to the Literature, Washington, D.C: American Psychiatric Press,
Inc. 1995, pp 113-128.
9.
Andreasen NC, Roy MA and Flaum M.: Positive and negative symptoms. In,
Hirsch SR and DR Weinberger (eds.). Schizophrenia. Blackwell Science Ltd.,
Oxford, England 1995, pp 28-45.
10.
Flaum M, and Andreasen NC: Brain morphology in schizotypal personality as
assessed by magnetic resonance imaging. In, Raine A, Lencz T, and S Mednick
(eds.). Schizotypal Personality. Cambridge University Press, 1995, pp 385-405.
11.
Andreasen NC, Arndt S, O’Leary D, Flaum M, and P Nopoulos: Clinical
presentation and cognitive dysfunction in schizophrenia. In, Brunello N, Racagni
G, Langer SZ, Mendlewicz J (eds): Critical issues in the treatment of
schizophrenia. Int Acad Biomed Drug Res. Basel, Karger, 1995, vol 10 pp 1-8.
12.
Flaum M: Nosological comments on culture and organic and psychotic disorders.
In, Messich JE, Kleinman A, Fabrega H Jr, and Parron D (eds.): Culture and
Psychiatric Diagnosis: A DSM-IV perspective. Washington, D.C:, American
Psychiatric Press, Inc. 1996, pp.75-78.
13.
Andreasen NC, O'Leary D, Arndt S, Cizadlo T, Nopoulos P, Flaum M: Neural
substrates of frontal function in schizophrenia. In: Dopamine Disease States,
Beninger RJ, Palomo T and T. Archer, eds. Madrid, Universidad Complutense,
Fundacion Cerebro y Mente, 1996, pp 523-536.
14.
Flaum M, Amador XA, Andreasen NC, Arndt SV, Bracha HS, Edell W,
McGlashan T, McGorry P, Pandurangi A, Robinson D, Ontiveros A and Tohen
M: The DSM-IV field trials for schizophrenia and other psychotic disorders. In,
Widiger TA, Frances AJ, Pincus HA et al, DSM-IV Sourcebook-Volume 4.
Washington D.C.: American Psychiatric Association., 1998, pp 687-713
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Michael Flaum, M.D.
C.
15.
Flaum, M, Andreasen NC and Widiger TA: Schizophrenia and other psychotic
disorders in DSM-IV: Final Overview. . In, Widiger TA, Frances AJ, Pincus HA
et al, DSM-IV Sourcebook-Volume 4. Washington D.C.: American Psychiatric
Association, 1998, pp 1007-1018 .
16.
Nopoulos P, Miller DD, Flaum M and NC Andreasen: Issues in the assessment
of negative symptom treatment response. In, Negative Symptom and Cognitive
Deficit Treatment Response in Schizophrenia, Keefe RSE and McEvoy JP eds.
Washington, DC; American Psychiatric Press, Inc., 2000, pp.19-31.
Selected Abstracts:
1.
Flaum M, Arndt SV and Andreasen NC: Short term clinical course following
abrupt discontinuation of antipsychotic medication in schizophrenia.
Schizophrenia Research.: 2;1, Jan./April 1989.
2.
Flaum M, Arndt SV, Fleming F. and Andreasen NC: The reliability and
frequency of "first-rank" symptoms in schizophrenia: Implications for DSM-IV.
International Congress on Schizophrenia Research, Tucson Arizona, April, 1991.
3.
Flaum M, O'Leary DS, Swayze VW, Alliger RJ, Stibolt O and NC Andreasen:
Decreased cranial and cerebral volume in schizophrenia: A magnetic resonance
imaging study. Society for Neuroscience Abstracts, 17(2):1454, 1991.
4.
O'Leary, DS, Kesler ML, Flaum M, Stibolt O and NC Andreasen: Cognitive
function and cerebral spinal fluid measures in schizophrenics and normals: A
magnetic resonance imaging study.
Society for Neuroscience Abstracts,
17(2):1454, 1991.
5.
Flaum M, Swayze VW, Gupta S, O’Leary DS, Andreasen NC: Symptom
domains and neural substrates of schizophrenia: A magnetic resonance imaging
study. Schizophrenia Research, 9:198, 1993.
6.
Flaum M, Arndt SV and Andreasen NC: The DSM-IV Field Trial for psychotic
disorders. Schizophrenia Research, 9:99, 1993.
7.
Arndt SV, Flaum M and Andreasen NC: Longitudinal patterns of prediction,
change and stability in positive and negative symptoms. Schizophrenia Research,
9:92, 1993.
8.
Flaum M, Hubbard WH, Arndt SV, Andreasen NC: The validity of subjective
reporting of positive and negative symptoms in schizophrenia. Schizophrenia
Research, 9:99, 1993.
9.
Nopoulos PC, Flaum M, Andreasen NC, Swayze VW: Gray matter heterotopias
in schizophrenia. Schizophrenia Research, 9:205, 1993.
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Michael Flaum, M.D.
10.
Roy MA, Flaum M, Arndt S, Crowe RR, Andreasen NC: Neuroanatomical
correlates of familial and sporadic schizophrenia. Schizophrenia Research,
9:208, 1993.
11.
Roy MA, Flaum M, Gupta S, Jaramillo L: Epidemiological and clinical
correlates of familial and sporadic schizophrenia. Schizophrenia Research, 9:139,
1993.
12.
Andreasen NC, Swayze V, O’Leary DS, Miller D, Flaum M, Gupta S: Structural
brain abnormalities revisited: Measurement of volumes and surface structures
based on three-dimensional magnetic resonance. Schizophrenia Research, 9:191,
1993.
13.
Gupta S, Rajaprabhakaran R, Arndt SV, Flaum M, Andreasen NC: Premorbid
adjustment as a predictor of phenomenological and neurobiological indices in
schizophrenia. Schizophrenia Research, 9:99, 1993.
14.
Swayze VW, Andreasen NC, O’Leary, Flaum M, Sickels W, Miller DD, and S
Ziebell: Long-term follow-up study of frontal lobotomy in schizophrenia.
Schizophrenia Research, 9:210, 1993.
15.
Flaum M, Arndt SV, Andreasen NC: The reliability of distinguishing “primary”
vs. “secondary” negative symptoms. 32nd annual meeting of the American
College of Neuropsychopharmacology , Honolulu, Hawaii, December 15, 1993.
16.
Nopoulos PC, Flashman LA, Flaum M, O’Leary DS, Andreasen NC: Stability of
neuropsychological function in schizophrenia over time. American College of
Neuropsychopharmacology 32nd annual meeting, Honolulu, Hawaii, December
13, 1993.
17.
Arndt S, Cizadlo T, Harris G, O’Leary DS, Flaum M, and Andreasen NC: The
correlation of IQ with brain size, surface complexity and curvature from MR
images in normal adults. American College of Neuropsychopharmacology 32nd
annual meeting, Honolulu, Hawaii, December 13, 1993.
18.
Okazaki Y, Andreasen NC, Okubo T, Minami Y, Maeda H, Nakane Y, Ochi M,
Flaum M, Arndt, S: Similarities and dissimilarities of brain structures of
identical twins concordant and discordant for schizophrenia. Presented at the
Winter Workshop on Schizophrenia. Les Diablerets, Switzerland, January 26,
1994.
19.
Andreasen NC, Harris G, Cizadlo T, Arndt SV, O'Leary D, Swayze V, Flaum M,
Yuh WTC, Ehrhardt J: A quantitative method for measuring sulcal and gyral
complexity: Brainplot and Brainmap. Schizophrenia Research, 11; 137, 1994.
20.
Gupta S, Hubbard WC, Flaum M, Arndt SV, Andreasen NC: The Iowa
prospective study of recent-onset psychoses: One year follow-up of symptoms
and psychosocial functioning in first episode patients. Schizophrenia Research,
11; 176, 1994.
12
Michael Flaum, M.D.
21.
Amador XF, Flaum M, Andreasen NC, Strauss DH, Gorman JM: Insight into
illness in schizophrenia and schizoaffective and mood disorders: Results from the
DSM-IV field trials. Schizophrenia Research, 11; 180, 1994.
22.
Gupta S, Hubbard WC, Arndt S, Flaum M, Andreasen NC: Neurological soft
signs in neuroleptic naive schizophrenic patients vs. normal controls.
Schizophrenia Research, 11; 195, 1994.
23.
Flaum M, O'Leary DS, Arndt SV, and Hichwa R. Acute effects of cigarette
smoking on cerebral blood flow: A PET study. "New Research", American
Psychiatric Association 147th Annual Meeting, Philadelphia, Pennsylvania.
24.
Flaum M. The diagnosis of schizophrenia in DSM-IV: How different? "New
Research", American Psychiatric Association 147th Annual Meeting,
Philadelphia, Pennsylvania.
25.
Flaum M, O'Leary DS, Cizadlo T, Arndt SV, Hichwa R, Kirchner P and N.C.
Andreasen. Acute effects of cigarette smoking on cerebral blood flow: A PET
study. American College of Neuropsychopharmacology, 33rd annual meeting.
San Juan, Puerto Rico, Dec. 12-16, 1994. Scientific Abstracts, p.148.
26.
Andreasen NC, Flaum M, Arndt SV, Hichwa R, O’Leary DS and JC Ehrhardt.
PET 15O H2O and functional MR for the study of regional cerebral blood flow: A
comparison. American College of Neuropsychopharmacology, 33rd annual
meeting. San Juan, Puerto Rico, Dec. 12-16, 1994. Scientific Abstracts, p.66.
27.
Kronengold H, Amador XF, Bracha HS, Flaum M, McGlashan T, Pandurangi A,
Robinson D, Tohen M: Schizophrenia, season of birth, and phenomenological
features. Schizophrenia Research, 15: 11, 1995.
28.
Gupta S, Flashman LA, Flaum M, Nopoulos PC, O’Leary DS, Andreasen NC: Is
the neuropsychological dysfunction in schizophrenia progressive? Schizophrenia
Research, 15, 120, 1995
29.
Marcinko L, Amador X, Flaum M, McGlashan T, Pandurangi A, Robinson D,
Tohen M: Gender differences in schizophrenia: Findings from the DSM-IV Field
Trials. Schizophrenia Research, 15: 16-17, 1995
30.
Miller DD, Flaum MA, Nopoulos P, Arndt S, Andreasen NC: The concept of
dose years: A reliable method for calculating lifetime psychotropic drug
exposure. Schizophrenia Research, 15:159, 1995
31.
Nopoulos P, Swayze V, Flaum M, Andreasen N: Structural brain abnormalities
in schizophrenic patients with and without cavum septi pellucidi as measured by
MRI. Schizophrenia Research, 15:94, 1995
32.
Strakowski SM, Flaum M, Amador X, Bracha HS, Pandurangi AK, Tohen M:
Racial differences in the expression of psychosis. Schizophrenia Research, 15: 21,
1995
13
Michael Flaum, M.D.
33.
Roy M-A, Flaum M, Andreasen NC. Winter and non-winter born Schizophrenic
cases: A comprehensive study. Schizophrenia Research , 15:47-48, 1995
34.
Flaum M, Sonka M, Arndt S, Cizadlo T, Stoneall S, and N.C. Andreasen: A new
automated method of identifying neuroanatomic regions of interest on imaging
data. American College of Neuropsychopharmacology, 34th annual meeting. San
Juan, Puerto Rico, Dec. 11-15, 1995. Scientific Abstracts, p. 233.
35.
Nopoulos PC, Flaum M, and N.C. Andreasen:
Gender differences in
schizophrenia:
Brain morphology. American College of Neuropsychopharmacology, 34th annual meeting. San Juan, Puerto Rico, Dec. 11-15, 1995.
Scientific Abstracts p. 159
36.
Flaum M,. Cizadlo T, Arndt S, O’Leary DS, Nopoulos P, Hurtig R, Zheng J, and
J.C. Ehrhardt: Informing the choice of activation thresholds in fMRI paradigms.
Neuroimage, 3:S59, 1996
37.
Flaum M, Sonka M, Arndt S, Cizadlo T, Stoneall S, and N.C. Andreasen:
Automated morphologic and functional analysis of neuroanatomic regions of
interest on MR imaging data. Neuroimage, 3: S131, 1996.
38.
Wassink TH, Rose S, Flaum M and NC Andreasen: The prevalence and
predictive validity of early depressive symptoms in the course of schizophrenia.
Schizophrenia Research, 24:25, 1997.
39.
Rodriquez R, Flaum M and PC Nopoulos: The effect of cumulative neuroleptic
exposure on caudate and putamen volumes. Schizophrenia Research, 24:154,
1997.
40.
Flaum M, O’Leary DS, Johnson D, Arndt S, Cizadlo T, Hichwa R and NC
Andreasen. Relationship between symptom dimensions and cerebral blood flow
in schizophrenia as assessed by 15H20 PET. Schizophrenia Research, 24:165,
1997.
41.
O’Leary DS, Andreasen NC, Hurtig RR, Arndt S, Flaum MA and RD Hichwa. A
PET study of auditory attention deficits in patients with schizophrenia: A
replication and extension of previous findings. Schizophrenia Research, 24:170,
1997.
42.
Ho BC, Flaum M and NC Andreasen: The dependence on financial support from
social agencies early in the course of schizophrenia. Schizophrenia Research,
24:223, 1997.
43.
Andreasen NC, Flaum M, Nopoulos P, Arndt S, Harris G, Heckel D, and T.
Cizadlo: Measurement of cortical surface anatomy in schizophrenia. Neuroimage,
5: S276, 1997.
14
Michael Flaum, M.D.
44.
Flaum M, Nopoulos P, Arndt S, Cizadlo T, and NC Andreasen: An MRI study
of gray matter, white matter and cerebral spinal fluid volumes in patients with
schizophrenia vs. normal controls. Neuroimage, 5: S277, 1997.
45.
Cizadlo T, Harris G, Heckel D, Flaum M, Christian BS, O’Leary DS and NC
Andreasen: An automated method to quantify the area, depth and convolutions of
the cerebral cortex from MR data: ("BRAINSURF"). Neuroimage, 5: S407, 1997.
46.
Flaum M, Sears L, Magnotta V, Ehrhardt J, O’Leary DS and NC Andreasen:
Development of an fMRI paradigm to assess cerebellar cortical vs. deep nuclei
activity in schizophrenia. Neuroimage, 7:S1005, 1998.
47.
O’Leary DS, Andreasen NC, Flaum M, Arndt S and Hichwa RD: “Broken
sensory filter verses “cognitive dysmetria”: A PET study of attentional processing
in schizophrenia. Neuroimage, 7:S99, 1998.
48.
Flaum M, Nopoulos P and NC Andreasen: Are morphologic changes in the
brains of patients with schizophrenia progressive? Schizophrenia Research: 36,
196, 1999.
49.
Nopoulos PC, Flaum M, O’Leary D, and NC Andreasen: Sexual dimorphism in
normal human brain: an MRI study of tissue composition and surface anatomy.
Schizophrenia Research: 36, 205, 1999.
50.
Flaum M, Magnotta V, Sears L, Arndt S, O’Leary DS, Miller D, and NC
Andreasen: Effects of olanzapine on regional cerebral blood flow as assessed by
functional magnetic resonance imaging in patients with schizophrenia.
Schizophrenia Research: 36, 221, 1999.
51.
Flaum M, Magnotta V, O’Leary DS, Sears L, Harris G and NC Andreasen: An
fMRI study of patients with schizophrenia, on and off the antipsychotic
medication olanzapine. Neuroimage, 1999.
52.
Ho BC, Nopoulos PC, Fuller RL, Sears L, O’Leary DS, Flaum M, and Andreasen
NC: The use of premorbid neurocognitive mesaures in early identification of
schizophrenia. Schizophrenia Research, 49:33, 2001
53.
O’Leary DS, Schultz SK, Flaum M, and NC Andreasen: Schizophrenia and durg
abuse: A PET study. Schizophrenia Research, 49:182, 2001
54.
Flaum M, Endicott J, and NC Andreasen: Introducing the “Quick-SANS” and
Quick-SAPS”:
Bringing clinical research methodology into the clinic.
Schizophrenia Research, 49:13, 2001
Active Grant / Contract Support: Michael Flaum, MD
Funding Source: State of Iowa, Department of Human Services
Contract #99-324-401-6490-2464-44
15
Michael Flaum, M.D.
Title: The Iowa Consortium for Mental Health Services, Training and Research
Role on Project: Director
Percent Effort: 20%
Salary Support: 20%
Total Project Period: 7/1/02-6/30/03
Current year funding: $150,000
Description: The goal of this consortium is to enhance the coordination and efficiency of
various providers of mental health services and academic institutions throughout the state
of Iowa. These include the three Iowa universities, the community mental health centers
and residential care facilites throughout the state, and the department of human services.
Funding Source: Magellan Behavioral Care of Iowa
Title: Technical Assistance Center for Evidence-Based Practices
Role on Project: Director
Salary Support: 20%
Total Project Period: 6/1/03 – 6/30/04
Total Project funding: $196,680
Description: The goal of this grant is to provide technical assistance, educational and
administrative support to mental health centers and other providers in Iowa engaged in 2
evidence based practices: 1) Assertive Community Treatment; and 2) Illness
management and recovery.
Funding Source: NIMH
Title: NIMH Constituency Outreach and Education Program
Role on project: Principle Investigator
Percent Effort: 3%
Salary Support: 0%
Active dates: 10/10/00 – 10/09/04
Current year funding: Direct: $5,000; Indirect: $0; Total: $5,000
Description: To provide an interface between the academic psychiatric community via
NIMH and the providers and recipients of mental health services in Iowa.
Funding Source: State of Iowa, Department of Human Services (Subcontract of a grant
from SAMHSA to Iowa DHS)
Title: Real Choices Systems Change Grant
Role on Project: Co-Investigator
Salary Support: 20%
Total Project Period: 7/1/02 – 9/30/04
Current year funding: ~ $600,000
Total Project funding: $1,375,000
Description: The goal of this “systems change” grant are to help Iowa DHS implement
its plan to respond to the Olmstead Decision. Activities involve efforts to minimize the
institutional bias within the states MH/MR/DD delivery system.
Funding Source: NIMH 5 T32 (MH19113)
Title: Research Training, Major Psychoses & Clinical Neurobiology
Role on project: Mentor (P.I.: N.C. Andreasen)
Percent Effort: 5%
16
Michael Flaum, M.D.
Salary Support: 0%
Active dates: 7/1/99 – 6/30/04
Current year funding: Direct: $204,167; Indirect: $18,598; Total: $222,765
Description: To provide postdoctoral research training to MD’s and Ph.D’s, focussing on
the neurobiology of Schizophrenia and related psychotic disorders
Recent Visiting Lectures
July 19, 2001: National Corrections Conference on Mental Illness
Boston Marriott Copley Place, Boston Massachusetts,
Title: Science and Policy: Exploring Treatment Options and Best Practices
August 21, 2001: Mental Health Policy Roundtables Panel
Cedar Rapids Public Library, Cedar Rapids, Iowa.
Title: Mental Health Corrections Policy Panel
September 13, 2002: Center for Rural Health and Primary Care Advisory Committee
Capitol Building, Des Moines, Iowa.
Title: Issues in Iowa’s Mental Health System
October 31, 2001: “From My Point of View: Iowa’s Mental Health System”
Hotel Fort Des Moines, Des Moines, Iowa
Title: Innovations in Mental Health: Moving Toward Best Practices
November 6-9, 2001 (8 presentations) Mental Health Issues in the Corrections System:
Public Hearings
Waterloo, Fort Dodge, Sioux City, Council Bluffs, Des Moines, Mount Pleasant,
Davenport, Cedar Rapids..
Title: Overview of Mental Health Issues in Iowa’s Correctional System
November 15, 2001: Iowa Judges Conference
Hotel Fort Des Moines, Des Moines, Iowa
Title: Identication and Treatment of Mental Illness
November 19, 2001: 3rd Annual National Corrections Telemedicine Conference
Lowes Ventana Canyon Resort, Tucson, Arizona
Title: Telepsychiatry
February 6, 2002: Mental Health Advocacy Coalition Legislative Parity Day
Iowa State Capitol, Des Moines,
Title: Mental Illness is a Brain Disorder
February 25, 2002: Rotary Club of Cedar Rapids, IA
Crowne Plaza Five Seasons Hotel, Cedar Rapids, IA.
Title: Mental Health and Corrections
17
Michael Flaum, M.D.
February 25, 2002: Mary Greeley Medical Center Board of Directors Meeting
Mary Greeley Medical Center, Ames, Iowa
Title: The Mental Health System in Iowa
April 19, 2002: Free Clinics of the Great Lakes Region 6th Annual Conference
Collins Plaza Hotel & Convention Center, Cedar Rapids, Iowa.
Title: Iowa’s Mental Health System
May 16, 2002: Mental Health and Corrections Conference
Crowne Plaza, Five Seasons Hotel, Cedar Rapids, Iowa.
Title: Iowa’s Mental Health and Corrections System
May 28, 2002: Mental Health, Addiction, and the Criminal Justice Systems: A
Collaborative Conference.
Holiday Inn, Columbus, Indiana.
Title: Keynote Address
June 5, 2002: American Telemedicine Association 7th Annual Meeting
Los Angeles Convention Center, June 2-5, 2002
Title: Telepsychiatry
June 18,19,25,26, July 9, 10, 2002: (six presentations) “From Streets to Cells and Back
Again: Addressing the Problems of the Mentally Ill Offender”: Day long regional
meetings to bring together corrections and community mental health staff:
Council Bluffs (6/18), Souix City (6/19), Waterloo (6/25), Mt. Pleasant (6/26), Newton
(7/9/02), Fort Dodge (7/10/02)
Title: Moderator and primary presenter for “Overview of the Issues”, and “Cases”
August 22, 29, September 6, 13, 20, 27: (six presentations) “From Streets to Cells and
Back Again: Addressing the Problems of the Mentally Ill Offender”: Video-conference
Didactic Series to provide information on mental illnesses common among offenders
Title: Moderator, and primary presenter for “Psychotic Disorders”
October 16, 2002
Meeting: Practical Strategies for Addressing Co-occurring Substance Abuse and Mental
Health Disorders in Correctional Settings.
Omni Shoreham Hotel, Washington, DC
Title: “Defining Your Target Population”
October 22, 2002
Meeting: 2002 Mental Health Conference: “Finding the Treasure”
Iowa State Center, Ames, IA
Title: “Welcome Address”
November 25, 2002
Meeting: 4th Annual National Corrections Telemedicine Conference
Lowes Ventana Canyon Resort, Tucson, Arizona
Title: “Plenary Session: Telepsychiatry”
18
Michael Flaum, M.D.
February 10, 2003
Meeting: 13th Annual Conference on State Mental Health Agency Services Research,
Program Evaluation and Policy
Baltimore, Maryland
Title: A Method to Evaluate and Disseminate the Utilization of Evidence-Based
Practices within a State
May 28, 2003
Meeting: 2003 Joint National Conference on Mental Health Block Grant and National
Conference on Mental Health Statistics
Marriott Wardman Park Hotel, Washington, D.C.
Title: “Using the Community Mental Health Block Grant to Promote the Implementation
of Evidence-Based Practices”
19