NANO TECNOLOGY FOR STROKE V.R. Sri Saran Balaji (indiasaranbalaji@gmail.com) N.Sumanth (sumanthnathella@gmail.com) B.Tech. Information Technology 4th Year. R.M.D. Engineering College. ABSTARCT: Concerning the adverse effects of stroke, blood stream, it is referred to as an we have implemented a system, which is embolus. electronically viable for the treatment of stroke. Currently there is no pre-diagnostic Blood does wonderful things like carrying treatment for strokes. Only with the help oxygen, cleaning waste products, and of be delivering cells and chemicals to fight prevented. Further, the formation of clot infection. But mess up its environment cannot be pre-determined by any of the and blood can cause all sorts of problems. electronic gadgets. The heart pushes blood cells to the far dietary control, strokes can recesses of the body, but it returns from Considering the present pathetic scenario the fingers, toes, arms and legs in veins in our mind, we have formulated a system, that are milked by the routine contractions wherein a nanobot is used for such a of the muscles that surround them. As you cause. With such a rapid development in walk, blood gets pushed back to the heart; the field of nano, we can extract an as you type, the muscles of your fingers enormous potential from these tiny-bots. and hands do the work to get the blood back. FORMATION OF CLOT: Blood converted from the liquid to solid Without that muscle movement, blood state is called as thrombus. The process by stagnates and has a tendency to clot. There which the blood clot is formed is called as are two parallel systems of veins in the coagulation. A blood clot or thrombus is legs and arms. The superficial set under stationary within the vessel or heart. If it the skin drains blood into the deeper set moves from that location through the through a set of connectors that have valves in place. So clots in the superficial of infection, and sometimes it's hard to tell system are filtered before they enter the the two apart, except by using ultrasound deep pipeline. No such luck for the deep to check the flow of blood in the veins. vein system. No valve, no filters, and it's a But the DVT is just the harbinger (sign) of straight shot to the heart and lungs if a clot potential disaster. If a clot has formed, it should form and break off. can grow and break off and float Deep venous thrombosis, or DVT, is the downstream. medical term for a blood clot in that deeper system. The symptoms of pain, swelling, and redness are similar to those EFFECTS OF STROKE: The brain is an extremely complex organ that controls various body functions. If a Stroke occurs and blood flow can't reach the region that controls a particular body function, that part of the body won't work as it should RightBrain The effects of a stroke depend on several factors including the location of the obstruction and how much brain tissue is affected. However, because one side of the brain controls the opposite side of the body, a stroke affecting one side will CAUSES OF STROKE: result in neurological complications on the side of the body if affects Clogging of arteries within the brain (for example, lacunar stroke) If stroke occurs in the brain's right side, the left side of the body (and the right side Hardening of the arteries leading to the of the face) will be affected, which could brain (for example, carotid artery produce any or all of the following: occlusion) 1. Paralysis on the left side of the body Hardening of the arteries leading to the 2. Vision problems brain (for example, carotid artery 3. Memory loss occlusion) LeftBrain If the stroke occurs in the left side of the brain, the right side of the body (and the left side of the face) will be affected, producing some or all of the following 1. Paralysis on the right side of the body 2. Speech/language problems 3. Slow, cautious, behavioral style. NANOBOTICAL APPROACH TO STROKE: STEP-BY-STEP PROCESS OF OUR SYSTEM: Our system adopts “stinger bots” which follows these procedures Our stinger locates the clot Meticulous analysis of the blood clot is done by our bots Administration of TPA and WARFARIN, which are “clot-busters” are used by nanobots to dissolve the clot. Periodical review of the diagnosis is done and an operational review of the process is retrieved. BASIC BLOCK DIAGRAM: BASIC BLOCK DIAGRAM OF OUR SYSTEM ANALYSING THE CLOT LOCATING THE CLOT DELIVERING THE TPA AND WARFARIN PERIODICAL REVIEW NANOBOT FLUZON OPERATIONAL REPORT LOCATION OF THE CLOT: A person with the symptoms of the stroke timege= win32com.client.Dispatch needs to be determined where the clot ("THROMBUS.ApplicationEMBOLUS") exactly lies. while This is one of the prior and mandatory time.sleep(0.5) steps of our system. print "waiting for camera to initialize" not embolus.IsInitialized(): Move the camera to a given latitude, longitude, Fluzon bots, which are specialized bots in image processing, are adopted for this purpose which adopts PHYTHON CODING . PHYTHON CODING altitude, tilt and azimuth of carotid artery Latitude= (latitude of thrombus) # Latitude in degrees. Between -90 and 90. FOR Longitude= (longitude of thrombus) FLUZON: # Longitude in degrees. Between -180 and 180. Import win32com.client, GE.SetCameraParams(latitude, longitude) BFOR a very important ratio determines the nature The clot determination is done by of the clot which is given an hierarchical order of concerning various aspects namely, preference based on the present condition of it, 1. Thickness 2. Density 3. Blood flow obstruction ratio which can be otherwise given as 1. and needs prior treatment immediately 2. which we denote it as BFOR 4. When 1 is denoted the case is very urgent When 2 is denoted the case lies between a normal ratio and an urgent case Oxygen ratio 3. When 3 is denoted the case is quite normal and treatment need not be done in a faster pace. Automatically a database is set up which analyses the case and urgency of the clot and the medicinal back up needed for the case DELIVERING THE TPA AND WARFARIN: The most important use for adopting nanobots is because they are excellent medicine carriers and they do it by taking it directly to the spot needed. The above figures shows the different process we adopt with our bots with over the last few years for the immediate respect to the location of the clot. Tpa one of the most important treatments treatment of a stroke is a medicine called Clear 3-D view of the dimensional TPA (which stands for tissue plasminogen analysis of the clot which is viewed by the activator). TPA is a very powerful “clot – doctor and the different ratios needed for buster” that is infused through the veins. If consideration is retrieved. given within the first three hours after the After this process a much more intense onset of the symptoms. TPA can significantly analysis work is done by getting the improve the patients outcome from the stroke information needed over the long term. The sooner the TPA is started . the better the outcome , so time is of ANALYSIS OF THE CLOT: After the clot is determined and various the essence. Warfarins is also sometimes used to prevent aspect ratios are noted, a very keen the recurrence of a stroke in other situations, diagnosis method has to be adopted for the such as with certain other heart conditions treatment of the clots. and conditions in which the blood has a tendency to clot on its own (hypercoagulable states). Patients taking warfarins need to have PERIODICAL REVIEW: As soon as this process, the different periodic blood checks to make sure that their parametrical readings taken before are again current dose is producing the desired effect. checked for conformation. So depending upon he case either TPA or It is seen that the patients health condition is warfarins are injected through the bots to back to normal by observing the factors for dissolve the clot. several times and it is made sure that in The nanobot that specializes in this field is every such check there is a very negative called the ‘stinger bots’. These bots have the result for stroke formation. property of delivering the medicine to the exact place needed. As we know that stroke patients need more therapies for early recovery, the process involved are implemented in this step OPERATIONAL REPORT: Based on the observations of the above processes an operational report of the patient is retrieved which indicates the 1. dissolvation factor of the clot (DF) 2. The blood flow obstruction ratio (BFOR) and 3. The oxygen content of the blood (OC) These factors are seen to it that they never cross the normal value for at least a month VARIOUS PARTS OF STINGER BOTS: STINGER bots provide us with three main time after the process has been performed. Only after that, the patient is discharged from the treatment. important factors before the operation has to be done. They are namely, ACOUSTIC SENSORS BIO SENSORS ENVORONMENTAL SENSORS All these three sensors categorize the given clot with the respective parameters involved and then the operation is carried out with intense care and observation. SPECIFIC ADVANTAGES OF OUR SYSTEM TO PATIENTS: 1. As the two nano bots that we are applying in our system is a constituent made of the same composition of the blood cells , the antibodies present in the human being won’t detect our system as a foreign particle , which eradicates the side effects. 2. The system is very safe as we have a step 3. THE THIRD MILLENNIUM BY LUIGI different risk factors of the body and has a FABBRIZZI.ANTONNIO keen eye on the parameters involved with it. POGGI,SPRINGER VERLAG including our elecronical system which balances the ratio of application. SALIENT FEATURES OF OUR SYSTEM: As of till now no elecronically viable system has been adopted for the treatment for strokes. The monitoring system is purely done by phython coding which has the following advantages No stroke treatment system has ever adopted phython coding as its source code The standard library of phython mirrored the c library o Phython boots faster than JAVA o Phython faster than java when it comes to parsing and processing large volumes of data(10 GB) at a time. REFERENCES: 1. PHYTHON LANGUAGE REFERENCE MANUAL BY GUIDO VAN ROSSIUM 2. NANO MEDICINE , VOLUME 11 A : BIOCOMPATIBILITY BY ROBERT A. FRIETAS Jr. 3. CHEMISTRY AT THE BEGINNING OF by step process which keeps monitoring the We have included a special theraphy concept 4. ENGINES OF CREATION :THE COMING ERA OF NANO BOTS BY K.ERIC DREXLER ANCHOR BOOKS. Programming Language Used: python