Age-Specific Death Rates are Maximum Likelihood Estimators of the Force of Mortality Assumed Constant in the Age Interval Griffith Feeney 19 August 2003 The age-specific death rate for any suitably defined two-dimensional set in the age-time plane is defined as the number of deaths occurring in this set divided by the number of person years lived by members of the exposed population in this set. Let the individuals in question be numbered i 1,2,..., n ; let xi and yi denote, respectively, the ages at which the i -th individual comes into and leaves exposure; and let S and D denote, respectively, the index sets of the individuals who survive and the individuals who die. The likelihood for the i-th individual, assuming a constant force of mortality m in the given region, is yi exp[ dx if i is in S xi and yi exp[ dx if i is in D xi The first expression is simply the probability of survival over the period of exposure for the i -th individual. The second expression is the probability of survival to the exact age at death times the instantaneous probability of death at that age. These expressions assume that does not depend on time or age within the age-time set for which the rate is defined. The likelihood for all individuals is the product e ( yi xi ) e ( yi xi ) . iS iD We want to choose so as to minimize this quantity. To do so we proceed in the usual way, by minimizing the log likelihood, which is ( y iS i xi ) log ( e ( yi xi ) ) iD 1 ( y i xi ) log( ) ( yi xi ) ( y i xi ) D log( ) ( yi xi ) iS iS ( y iAll i iD iD iD xi ) D log( ) PYL D log( ) To find the minimizing we take the derivative of this log likelihood with respect to and equate it to zero, PYL D 0, for which the solution is D . PYL The right hand side is by definition the occurrence-exposure rate. Thus we have shown that the occurrence-exposure rate is a maximum likelihood estimate of the force of mortality when is assumed constant over the times and ages at which exposure occurs. 2