姓名：唐德成
科部：內科部腎臟科
聯絡方式：
電話
+886-2-27812121 Ext. 7517
Email
dctarng@vghtpe.gov.tw
學歷：
國立陽明大學 醫學院醫學士﹙19801987﹚
國立陽明大學 臨床醫學研究所醫學博士﹙19982002﹚
美國哈佛大學 Brigham & Women's Hospital 博士後研究﹙20022003﹚
經歷：
台北榮民總醫院 內科部腎臟科 主任﹙2015迄今﹚
台北榮民總醫院 免疫學研究中心 主任﹙20132014﹚
國立陽明大學 傳統醫學研究所 教授﹙2009迄今﹚
國立陽明大學 臨床醫學研究所 教授﹙2005迄今﹚
國立陽明大學 生理研究所 教授﹙2004迄今﹚
國立陽明大學 醫學院醫學系 教授﹙2003迄今﹚
國立陽明大學 生理學科主任暨研究所所長﹙20062008﹚
研究方向：
1.
2.
3.
4.
運用『基因合成人類紅血球生成素』治療『腎性貧血』之療效。
腎臟病患者之『氧化壓力』與『DNA 氧化傷害』研究。
『急性腎臟病』之基礎研究與治療。
『慢性腎臟病』之基礎研究與防治。
五年內研究著作：
2016
1.
Lee KH, Chen YT, Chung HJ, Liu JS, Hsu CC, Tarng DC*. Kidney disease
progression in patients of upper tract urothelial carcinoma following unilateral
radical nephroureterectomy. Ren Fail. 2016 Feb;38(1):77-83.
2.
Hung SC, Tarng DC*. Reversed association between aldosterone and mortality
in hemodialysis patients: Role of volume overload. Steroids. 2016 Jan 27. pii:
S0039-128X(16)00013-1.
3.
Shih CJ, Ou SM, Chao PW, Kuo SC, Lee YJ, Yang CY, Tarng DC, Lin CC,
Huang PH, Li SY, Chen YT. Risks of Death and Stroke in Patients Undergoing
Hemodialysis With New-Onset Atrial Fibrillation: A Competing-Risk Analysis of
a Nationwide Cohort. Circulation. 2016 Jan 19;133(3):265-72.
2015
4.
Tarng DC*, Liu IS, Lin LC, Chen NJ. Attenuation of Tubular Injury and Renal
Fibrosis by TI-HU-YIN via Reduction in Transforming Growth Factor-β1
Expression in Unilateral Ureteral Obstruction Mice. Chin J Physiol. 2015 Dec
31;58(6).
5.
Li SY, Huang PH, Tarng DC, Lin TP, Yang WC, Chang YH, Yang AH, Lin CC,
Yang MH, Chen JW, Schmid-Schönbein GW, Chien S, Chu PH, Lin SJ.
Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in
Diabetic Kidney Disease. J Am Soc Nephrol. 2015 Dec;26(12):3072-84.
6.
Kuo KL, Hung SC, Liu JS, Chang YK, Hsu CC, Tarng DC*. Add-on Protective
Effect of Pentoxifylline in Advanced Chronic Kidney Disease Treated with
Renin-Angiotensin-Aldosterone System Blockade - A Nationwide Database
Analysis. Sci Rep. 2015 Nov 27;5:17150.
7.
Ou SM, Shih CJ, Chao PW, Chu H, Kuo SC, Lee YJ, Wang SJ, Yang CY, Lin
CC, Chen TJ, Tarng DC, Li SY, Chen YT. Effects on Clinical Outcomes of
Adding Dipeptidyl Peptidase-4 Inhibitors Versus Sulfonylureas to Metformin
Therapy in Patients With Type 2 Diabetes Mellitus. Ann Intern Med. 2015 Nov
3;163(9):663-72.
8.
Yen HW, Yang WC, Tarng DC, Yang CY, Chuang CL, Huang LJ, Lin PY,
Wang CC, Li SY. Daptomycin antibiotic lock therapy for hemodialysis patients
with Gram-positive bloodstream infections following use of tunneled, cuffed
hemodialysis catheters: retrospective single center analysis. Hemodial Int. 2015
Nov 9. doi: 10.1111/hdi.
9.
Chien SC, Ou SM, Shih CJ, Chao PW, Li SY, Lee YJ, Kuo SC, Wang SJ, Chen
TJ, Tarng DC,
Chu
H,
Chen
YT.
Comparative
Effectiveness
of
Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
in Terms of Major Cardiovascular Disease Outcomes in Elderly Patients: A
Nationwide Population-Based Cohort Study. Medicine (Baltimore). 2015
Oct;94(43):e1751.
10. Wu CC, Hsieh MY, Hung SC, Kuo KL, Tsai TH, Lai CL, Chen JW, Lin SJ, Huang
PH, Tarng DC*. Serum Indoxyl Sulfate Associates with Postangioplasty Thrombosis
of Dialysis Grafts. J Am Soc Nephrol. 2015 Oct 9. pii: ASN.2015010068.
11. Weng SC, Shu KH, Wu MJ, Wen MC, Hsieh SL, Chen NJ*, Tarng DC*.
Expression of decoy receptor 3 in kidneys is associated with allograft survival
after kidney transplant rejection. Sci Rep. 2015 Sep 3;5:12769.
12. Hung SC, Chang YK, Liu JS, Hsu CC, Tarng DC*. Mortality and metformin use
in patients with advanced chronic kidney disease - Authors' reply. Lancet
Diabetes Endocrinol. 2015 Sep;3(9):681.
13. Kuo KL, Hung SC, Liu JS, Chang YK, Hsu CC*, Tarng DC*. Iron
supplementation associates with low mortality in pre-dialyzed advanced chronic
kidney disease patients receiving erythropoiesis-stimulating agents: a nationwide
database analysis. Nephrol Dial Transplant. 2015 Sep;30(9):1518-25.
14. Wang WY, Tarng DC, Chiang LC, Chu CM, Wang KY*. Evaluation of uraemic
pruritus in long-term dialysis patients using a modified Chinese scale. Nephrology
(Carlton). 2015 Sep;20(9):632-8.
15. Tsai MT, Chen YT, Lin CH, Huang TP, Tarng DC*. U-shaped curve mortality
associated with platelet count among older people: a community-based cohort
study. Blood. 2015 Aug 11. pii: blood-2015-06-654764.
16. Chen YT, Shih CJ, Ou SM, Hung SC, Lin CH, Tarng DC*; Taiwan Geriatric
Kidney Disease (TGKD) Research Group. Periodontal Disease and Risks of
Kidney Function Decline and Mortality in Older People: A Community-Based
Cohort Study. Am J Kidney Dis. 2015 Aug;66(2):223-30.
17. Hung SC, Chang YK, Liu JS, Kuo KL, Chen YH, Hsu CC*, Tarng DC*.
Metformin use and mortality in patients with advanced chronic kidney disease:
national, retrospective, observational, cohort study. Lancet Diabetes Endocrinol.
2015 Aug;3(8):605-14.
18. Tseng PY, Yang WC, Yang CY*, Tarng DC*. Long-term Outcomes of
Parathyroidectomy
in
Kidney
Transplant
Recipients
with
Persistent
Hyperparathyroidism. Kidney Blood Press Res. 2015 Jul 14;40(4):386-394.
19.
Tarng DC*, Tseng WC, Lee PY, Chiou SH, Hsieh SL. Induced Pluripotent
Stem Cell-derived Conditioned Medium Attenuates Acute Kidney Injury by
Downregulating the Oxidative Stress-Related Pathway in Ischemia-Reperfusion
Rats. Cell Transplant. 2015 Jun 30.
20. Chang CC, Wu CL, Su WW, Shih KL, Tarng DC, Chou CT, Chen TY, Kor CT,
Wu HM. Interferon gamma-induced protein 10 is associated with insulin
resistance and incident diabetes in patients with nonalcoholic fatty liver disease.
Sci Rep. 2015 May 11;5:10096. doi: 10.1038/srep10096.
21.
Hung SC, Lai YS, Kuo KL, Tarng DC*. Volume overload and adverse
outcomes in chronic kidney disease: clinical observational and animal studies. J
Am Heart Assoc. 2015 May 5;4(5).
22. Li SY, Huang PH, Tarng C, Lin TP, Yang WC, Chang YH, Yang AH, Lin CC,
Yang MH, Chen JW, Schmid-Schönbein GW, Chien S, Chu PH, Lin SJ.
Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in
Diabetic Kidney Disease. J Am Soc Nephrol. 2015 Apr 8. pii: ASN.2014100989.
[Epub ahead of print]
23. Shih CJ, Wu YL, Lo YH, Kuo SC, Tarng DC, Lin CC, Ou SM, Chen YT.
Association of Hypoglycemia With Incident Chronic Kidney Disease in Patients
With Type 2 Diabetes: A Nationwide Population-Based Study. Medicine
(Baltimore). 2015 Apr;94(16):e771.
24. Ou SM, Chen YT, Shih CJ, Tarng DC*. Increased risk of bone fracture among
patients with urinary calculi: a nationwide longitudinal population-based study.
Osteoporos Int. 2015 Apr;26(4):1261-9.
25. Hung SC, Kuo KL, Peng CH, Wu CH, Wang YC, Tarng DC*. Association of
fluid retention with anemia and clinical outcomes among patients with chronic
kidney disease. J Am Heart Assoc. 2015 Jan 5;4(1):e001480.
26. Chiang CW, Lee HT, Tarng DC, Kuo KL, Cheng LC, Lee TS*. Genetic deletion
of soluble epoxide hydrolase attenuates inflammation and fibrosis in experimental
obstructive nephropathy. Mediators Inflamm. 2015;2015:693260.
27. Chen YH, Chiang MH, Liu JS, Chang YK, Kuo KL, Hung SC, Tai HL, Hsu
CC*, Tarng DC*. Thiazolidinediones and Risk of Long-Term Dialysis in
Diabetic Patients with Advanced Chronic Kidney Disease: A Nationwide Cohort
Study. PLoS One. 2015 Jun 17;10(6):e0129922.
2014
28. Wu PC, Wu VC, Tarng DC*. Chronic kidney disease in Taiwan's aging
population: something far more than a distant ship's smoke on the horizon. J
Formos Med Assoc. 2014 Dec;113(12):890-1.
29. Chu H, Shih CJ, Lee YJ, Kuo SC, Hsu YT, Ou SM, Shih YN, Tarng DC, Li SY,
Chen YT*, Chen RCB*. Risk of tuberculosis among healthcare workers in an
intermediate-burden country: a nationwide population study. J Infect. 2014
Dec;69(6):525-32.
30. Lo TH, Tseng KY, Tsao WS, Yang CY, Hsieh SL, Chiu AW, Takai T, Mak
TW*, Tarng DC*, Chen NJ*. TREM-1 regulates macrophage polarization in
ureteral obstruction. Kidney Int. 2014 Dec;86(6):1174-86.
31. Shih CJ†, Chen YT†, Ou SM, Yang WC, Chen TJ, Tarng DC*. Urinary calculi
and risk of cancer: a nationwide population-based study. Medicine (Baltimore).
2014 Dec;93(29):e342.
32. Hung SC, Kuo KL, Tarng DC*, Hsu CC, Wu MS, Huang TP. Anaemia
management in patients with chronic kidney disease: Taiwan practice guidelines.
Nephrology (Carlton). 2014 Dec;19(12):735-9.
33. Shih CJ†, Chu H†, Chao PW, Lee YJ, Kuo SC, Li SY, Tarng DC, Yang CY,
Yang WC, Ou SM*, Chen YT*. Long-term clinical outcome of major adverse
cardiac
events
in
survivors
of
infective
endocarditis:
a
nationwide
population-based study. Circulation. 2014 Nov 4;130(19):1684-91.
34. Chao PW, Shih CJ, Lee YJ, Tseng CM, Kuo SC, Shih YN, Chou KT, Tarng DC,
Li SY, Ou SM, Chen YT. Association of postdischarge rehabilitation with
mortality in intensive care unit survivors of sepsis. Am J Respir Crit Care Med.
2014 Nov 1;190(9):1003-11.
35. Chen YH, Kuo KL, Hung SC, Hsu CC, Chen YH*, Tarng DC*. Length
polymorphism in heme oxygenase-1 and risk of CKD among patients with
coronary artery disease. J Am Soc Nephrol. 2014 Nov;25(11):2669-77.
(*:co-corresponding author)
36. Kuo KL, Hung SC, Lee TS*, Tarng DC*. Iron sucrose accelerates early
atherogenesis by increasing superoxide production and upregulating adhesion
molecules in CKD. J Am Soc Nephrol. 2014 Nov;25(11):2596-606.
37. Shih CJ†, Chen YT†, Ou SM, Yang WC, Kuo SC, Tarng DC*; for the Taiwan
Geriatric Kidney Disease Research (TGKD) Group. The impact of dialysis
therapy on older patients with advanced chronic kidney disease: a nationwide
population-based study. BMC Med. 2014 Oct 6;12(1):169.
38.
Hsu CC, Liu JS, Tarng DC*. Angiotensin-converting enzyme inhibitor or
Angiotensin receptor blocker use and renal outcomes-reply. JAMA Intern Med.
2014 Oct;174(10):1706-7.
39. Hung SC, Tarng DC*. ESA and iron therapy in chronic kidney disease: a balance
between patient safety and hemoglobin target. Kidney Int. 2014 Oct;86(4):676-8.
40. Li SY*, Huang PH*, Yang AH, Tarng DC, Yang WC, Lin CC, Chen JW,
Schmid-Schönbein G, Lin SJ. Matrix metalloproteinase-9 deficiency attenuates
diabetic nephropathy by modulation of podocyte functions and dedifferentiation.
Kidney Int. 2014 Aug;86(2):358-69.
41. Wu CK, Hung HF, Leu JG, Tarng DC, Tsai MH, Chiang SS. The immediate and
one-year outcomes of dialysis patients with refractory angina treated by enhanced
external counterpulsation. Clin Nephrol. 2014 Jul;82(1):34-40.
42. Shih CJ, Tarng DC, Yang WC, Yang CY*. Immunosuppressant dose reduction
and long-term rejection risk in renal transplant recipients with severe bacterial
pneumonia. Singapore Med J. 2014 Jul;55(7):372-7.
43. Kosik RO, Tran DT, Fan AP, Mandell GA, Tarng DC, Hsu HS, Chen YS, Su TP,
Wang SJ, Chiu AW, Lee CH, Hou MC, Lee FY, Chen WS, Chen Q. Physician
Scientist Training in the United States: A Survey of the Current Literature. Eval
Health Prof. 2014 Mar 31. [Epub ahead of print]
44. Hsu TW, Liu JS, Hung SC, Kuo KL, Chang YK, Chen YC, Hsu CC*, Tarng
DC*. Renoprotective effect of renin-angiotensin-aldosterone system blockade in
patients with predialysis advanced chronic kidney disease, hypertension, and
anemia. JAMA Intern Med. 2014 Mar;174(3):347-54.
45. Hung SC, Kuo KL, Peng CH, Wu CH, Lien YC, Wang YC, Tarng DC*. Volume
overload correlates with cardiovascular risk factors in patients with chronic
kidney disease. Kidney Int. 2014 Mar;85(3):703-9.
46. Tsai MT†, Hu FH†, Lien TJ, Chen PJ, Huang TP, Tarng DC*. Interaction
between geriatric nutritional risk index and decoy receptor 3 predicts mortality in
chronic hemodialysis patients. Am J Nephrol. 2014;40(3):191-9.
47. Tseng PY, Tarng DC, Yang WC, Yang CY*. Benign pneumatosis intestinalis.
Intern Med. 2014;53(14):1589-90.
48. Hung SC, Lin YP, Tarng DC*. Erythropoiesis-stimulating agents in chronic
kidney disease: what have we learned in 25 years? J Formos Med Assoc. 2014
Jan;113(1):3-10. Review.
49. Wu CL†, Wu HM†, Chiu PF, Liou HH, Chang CB, Tarng DC*, Chang CC*.
Associations between the duration of dialysis, endotoxemia, monocyte
chemoattractant protein-1, and the effects of a short-dwell exchange in patients
requiring continuous ambulatory peritoneal dialysis. PLoS One. 2014 Oct
6;9(10):e109558.
50. Weng SC†, Tarng DC†, Chen CM, Cheng CH, Wu MJ, Chen CH, Yu TM, Shu
KH*; CKDBHPDH investigators. Estimated glomerular filtration rate decline is a
better risk factor for outcomes of systemic disease-related nephropathy than for
outcomes of primary renal diseases. PLoS One. 2014 Apr 2;9(4):e92881.
51. Weng SC, Shu KH, Tarng DC, Cheng CH, Chen CH, Yu TM, Chuang YW,
Huang ST, Wu MJ*. Uric acid is highly associated with kidney allograft survival
in a time-varying analysis. Transplant Proc. 2014;46(2):505-10.
52. Weng SC, Shu KH, Wu MJ, Cheng CH, Chen CH, Yu TM, Chuang YW, Huang
ST, Tarng DC*. Hyperuricemia predicts kidney disease progression after acute
allograft dysfunction. Transplant Proc. 2014;46(2):499-504.
2013
53. Shih YC, Lee PY, Cheng H, Tsai CH, Ma H, Tarng DC*. Adipose-derived stem
cells exhibit antioxidative and antiapoptotic properties to rescue ischemic acute
kidney injury in rats. Plast Reconstr Surg. 2013 Dec;132(6):940e-51e.
54. Chen YH, Hung SC, Tarng DC*. Length polymorphism in heme oxygenase-1
and cardiovascular events and mortality in hemodialysis patients. Clin J Am Soc
Nephrol. 2013 Oct;8(10):1756-63.
55. Huang HL, Yang WY, Pu HF, Tsai TH, Lin CH, Chen NJ, Tarng DC*.
Krüppel-like factor 5 associates with melamine-cyanurate crystal-induced
nephritis in rats. Nephrol Dial Transplant. 2013 Oct;28(10):2477-83.
56. Hsu TW, Kuo KL, Hung SC, Huang PH, Chen JW, Tarng DC*. Progression of
kidney disease in non-diabetic patients with coronary artery disease: predictive
role of circulating matrix metalloproteinase-2, -3, and -9. PLoS One. 2013 Jul
26;8(7):e70132.
57. Lee WL, Cheng MH, Tarng DC, Yang WC, Lee FK, Wang PH. The benefits of
estrogen or selective estrogen receptor modulator on kidney and its related
disease-chronic kidney disease-mineral and bone disorder: osteoporosis. J Chin
Med Assoc. 2013 Jul;76(7):365-71. Review.
58. Tseng WC, Yang WC, Yang AH, Hsieh SL, Tarng DC*. Expression of
TNFRSF6B in kidneys is a novel predictor for progression of chronic kidney
disease. Mod Pathol. 2013 Jul;26(7):984-94.
59. Weng SC, Tarng DC*. Contrast-induced acute kidney injury in frail older people:
what do we learn from the dilemma? J Chin Med Assoc. 2013 May;76(5):239-40.
60. Shih CJ, Tarng DC, Yang WC, Yang CY*. Parathyroidectomy reduces
intradialytic
hypotension
in
hemodialysis
patients
with
secondary
hyperparathyroidism. Kidney Blood Press Res.
61. Hung SC†, Lin YP†, Huang HL, Pu HF, Tarng DC*. Aldosterone and mortality
in hemodialysis patients: role of volume overload. PLoS One. 2013;8(2):e57511.
62. Weng SC, Shu KH, Tarng DC, Tang YJ, Cheng CH, Chen CH, Yu TM, Chuang
YW, Huang ST, Sheu WH, Wu MJ. In-hospital mortality risk estimation in
patients with acute nonvariceal upper gastrointestinal bleeding undergoing
hemodialysis: a retrospective cohort study. Ren Fail. 2013;35(2):243-8.
2012
63. Chang EP, Lin YS, Huang SC, Tarng DC, Huang TP*. High serum DcR3 levels
are associated with the occurrence of peritonitis in patients receiving chronic
peritoneal dialysis. J Chin Med Assoc. 2012 Dec;75(12):644-8.
64. Tseng WC, Tarng DC*. Cocoon-like fibroadhesive tuberculous peritonitis in a
peritoneal dialysis patient. Chin J Physiol. 2012 Oct 31;55(5):361-5. Case Report.
65. Li SY*, Chen YT, Yang WC, Tarng DC, Lin CC, Yang CY, Liu WS. Effect of
add-on direct renin inhibitor aliskiren in patients with non-diabetes related
chronic kidney disease. BMC Nephrol. 2012 Aug 23;13:89.
66. Hung SC, Hsu TW, Lin YP, Tarng DC*. Decoy receptor 3, a novel inflammatory
marker, and mortality in hemodialysis patients. Clin J Am Soc Nephrol. 2012
Aug;7(8):1257-65.
67. Lai JN, Wang OY, Lin VH, Liao CF, Tarng DC*, Chien EJ*. The non-genomic
rapid acidification in peripheral T cells by progesterone depends on intracellular
calcium increase and not on Na+/H+-exchange inhibition. Steroids. 2012
Aug;77(10):1017-24.
68. Chen YH, Chen HS*, Tarng DC*. More impact of microalbuminuria on
retinopathy than moderately reduced GFR among type 2 diabetic patients.
Diabetes Care. 2012 Apr;35(4):803-8.
69. Weng SC, Shu KH, Tarng DC, Wu MJ, Chen CH, Yu TM, Chuang YW, Huang
ST, Cheng CH*. Gene polymorphisms are associated with posttransplantation
diabetes mellitus among Taiwanese renal transplant recipients. Transplant Proc.
70. Chen WS, Liu CY, Lee HT, Tsai K, Lin YC, Tarng DC, Ho CH, Lin HY. Effects
of intravenous iron saccharate on improving severe anemia in rheumatoid arthritis
patients. Clin Rheumatol. 2012 Mar;31(3):469-77.
71. Tai SK†, Chang HC†, Lan KL, Lee CT, Yang CY, Chen NJ, Chou TY, Tarng DC,
Hsieh SL*. Decoy receptor 3 enhances tumor progression via induction of
tumor-associated macrophages. J Immunol. 2012 Mar 1;188(5):2464-71.
72. Lin YS, Tarng DC*. Abnormal thyroid function in peritoneal dialysis patients:
lots of smoke but no fire. J Chin Med Assoc. 2012 Feb;75(2):47-8.
73. Lee PY, Chien Y, Chiou GY, Lin CH, Chiou CH*, Tarng DC*. Induced
pluripotent stem cells without c-Myc attenuate acute kidney injury via
downregulating the signaling of oxidative stress and inflammation in
ischemia-reperfusion rats. Cell Transplant. 2012;21(12):2569-85.
74. Weng SC, Shu KH, Tang YJ, Sheu WH, Tarng DC, Wu MJ, Chen YM, Chuang
YW*. Progression of cognitive dysfunction in elderly chronic kidney disease
patients in a veteran's institution in central Taiwan: a 3-year longitudinal study.
Intern Med. 2012;51(1):29-35.
75. Kuo KL, Hung SC, Lin YP, Tang CF, Lee TS, Lin CP*, Tarng DC*. Intravenous
ferric chloride hexahydrate supplementation induced endothelial dysfunction and
increased cardiovascular risk among hemodialysis patients. PLoS One.
2012;7(12):e50295.
研究室成員：楊子旻、李岳航、李宜晉、曾伊賞