DNA Databank Demonstration Project Atrial fibrillation Data source summary: Cases Possible/ Probable Controls Excluded from Analysis Diagnostic Codes? Yes (Absence of codes) Yes Text Keywords? Disease only Disease only Yes(Absence of codes) Yes Disease only Disease only Narrative Notes to search Other rules ECG Impression ECG Impression, H&P, Discharge summary, all notes ECG Impression, H&P, Discharge summary, all notes ECG Impression, H&P, Discharge summary, all notes May require manual curation of all records Must have ECG Pre-Analysis: Validation of impression with diagnosis CASES: Case Definition: ECG Impression = Atrial Fibrillation keywords AND NOT CPT/ICD 9 codes = heart transplant Subcase 1: ECG Impression = Atrial Fibrillation keywords AND NOT (ECG Impression = Myocardial infarction keywords within 14 days (pre or post) OR CPT/ICD 9 codes = cardiac surgery) Subcase 2: ECG Impression = Atrial Fibrillation keywords AND (ECG Impression = Myocardial infarction keywords within 14 days (pre or post) OR CPT/ICD 9 codes = cardiac surgery) Page 1 of 10 Case/Possible: Text of notes = Atrial Fibrillation or atrial flutter OR ICD 9 codes = Atrial Fibrillation or atrial flutter CONTROLS: Record contains none of the above AND NOT ICD-9 codes = Atrial flutter / atrial fibrillation AND NOT Keywords = Atrial flutter, Atrial tachycardia Note: Record must contain at least one ECG (without AF keywords) INDEX Case Keywords (any of the below) for ECGs: REGEXP_LIKE(IMPRESSION,'((^|[ \.])AF($|[ \.]))|(a\w*[ .]?(fib[\w]*|flutter))','i') This should match: Afib A* fib* AF Aflutter A* flutter Case Possible Keywords (any of the below): Atrial fibrillation [fibrulation] [fabrillation] [fibrilation]; A fibrillation; A fib; afib; Atrial fib; atr fib*, auricular fib*; aflutter, atrial flutter Control Keywords (any of the below): Atrial flutter; A Flutter; Aflutter; AFL; Direct current cardioversion; Cardioverted; DCCV; DC cardioversion; Shocked; Atrial tachycardia1 [tachyardia] [tachychardia] [tachyacardia] [tachycardic]; Atach; MAT; Multifocal atrial tachycardia; Atrioventricular nodal [node] ablation [oblation]; AV nodal ablation; nodal catheter ablation Case CPT codes (any of the below) Description CPT Code “AT” will not be used - obviously will be tough because there will be so many 'at' references in the med record 1 Page 2 of 10 Anesthesia for direct coronary artery bypass grafting without pump oxygenator Thoracotomy, major; with cardiac massage Excision of intracardiac tumor, resection with cardiopulmonary bypass Resection of external cardiac tumor Transmyocardial laser revascularization, by thoracotomy; performed at the time of other open cardiac procedure(s) (List separately in addition to code for primary procedure) Operative tissue ablation and reconstruction of atria, performed at the time of other cardiac procedure(s), limited (eg, modified maze procedure) (List separately in addition to code for primary procedure) Operative tissue ablation and reconstruction of atria, performed at the time of other cardiac procedure(s), extensive (eg, maze procedure), without cardiopulmonary bypass (List separately in addition to code for primary procedure) Operative tissue ablation and reconstruction of atria, performed at the time of other cardiac procedure(s), extensive (eg, maze procedure), with cardiopulmonary bypass (List separately in addition to code for primary procedure) Repair of cardiac wound; without bypass Repair of cardiac wound; with cardiopulmonary bypass Cardiotomy, exploratory (includes removal of foreign body, atrial or ventricular thrombus); without bypass Cardiotomy, exploratory (includes removal of foreign body, atrial or ventricular thrombus); with cardiopulmonary bypass Valvuloplasty, aortic valve; open, with cardiopulmonary bypass Valvuloplasty, aortic valve; open, with inflow occlusion Valvuloplasty, aortic valve; using transventricular dilation, with cardiopulmonary bypass Construction of apical-aortic conduit Replacement, aortic valve, with cardiopulmonary bypass; with prosthetic valve other than homograft or stentless valve Replacement, aortic valve, with cardiopulmonary bypass; with allograft valve (freehand) Replacement, aortic valve, with cardiopulmonary bypass; with stentless tissue valve Replacement, aortic valve; with aortic annulus enlargement, noncoronary cusp Replacement, aortic valve; with transventricular aortic annulus enlargement (Konno procedure) Replacement, aortic valve; by translocation of autologous pulmonary valve with allograft replacement of pulmonary valve (Ross procedure) Resection or incision of subvalvular tissue for discrete subvalvular aortic stenosis 566 32160 33120 33130 33141 33257 33258 33259 33300 33305 33310 33315 33400 33401 33403 33404 33405 33406 33410 33411 33412 33413 33415 Page 3 of 10 Ventriculomyotomy (-myectomy) for idiopathic hypertrophic subaortic stenosis (eg, asymmetric septal hypertrophy) Valvotomy, mitral valve; closed heart Valvotomy, mitral valve; open heart, with cardiopulmonary bypass Valvuloplasty, mitral valve, with cardiopulmonary bypass; Valvuloplasty, mitral valve, with cardiopulmonary bypass; with prosthetic ring Valvuloplasty, mitral valve, with cardiopulmonary bypass; radical reconstruction, with or without ring Replacement, mitral valve, with cardiopulmonary bypass Valvectomy, tricuspid valve, with cardiopulmonary bypass Valvuloplasty, tricuspid valve; without ring insertion Valvuloplasty, tricuspid valve; with ring insertion Replacement, tricuspid valve, with cardiopulmonary bypass Tricuspid valve repositioning and plication for Ebstein anomaly Valvotomy, pulmonary valve, closed heart; transventricular Valvotomy, pulmonary valve, closed heart; via pulmonary artery Valvotomy, pulmonary valve, open heart; with inflow occlusion Valvotomy, pulmonary valve, open heart; with cardiopulmonary bypass Replacement, pulmonary valve Repair of coronary arteriovenous or arteriocardiac chamber fistula; with cardiopulmonary bypass Repair of coronary arteriovenous or arteriocardiac chamber fistula; without cardiopulmonary bypass REPAIR OF ANOMALOUS AORTIC ORIGIN OF CORONARY ARTERY BY UNROOF OR TRANSLOCA Repair of anomalous (eg, intramural) aortic origin of coronary artery by unroofing or translocation Coronary endarterectomy, open, any method, of left anterior descending, circumflex, or right coronary artery performed in conjunction with coronary artery bypass graft procedure, each vessel (List separately in addition to primary procedure) Closure of atrioventricular valve (mitral or tricuspid) by suture or patch Closure of semilunar valve (aortic or pulmonary) by suture or patch Repair of complex cardiac anomaly other than pulmonary atresia with ventricular septal defect by construction or replacement of conduit from right or left ventricle to pulmonary artery Repair of complex cardiac anomalies (eg, single ventricle with subaortic obstruction) by surgical enlargement of ventricular septal defect Repair of complex cardiac anomalies (eg, tricuspid atresia) by closure of atrial septal defect and anastomosis of atria or vena cava to pulmonary artery (simple Fontan procedure) Repair of complex cardiac anomalies (eg, single ventricle) by modified Fontan procedure 33416 33420 33422 33425 33426 33427 33430 33460 33463 33464 33465 33468 33470 33471 33472 33474 33475 33500 33501 33507 33572 33600 33602 33608 33610 33615 33617 Page 4 of 10 Repair of single ventricle with aortic outflow obstruction and aortic arch hypoplasia (hypoplastic left heart syndrome) (eg, Norwood procedure) Repair atrial septal defect, secundum, with cardiopulmonary bypass, with or without patch Repair of atrial septal defect and ventricular septal defect, with direct or patch closure Repair of incomplete or partial atrioventricular canal (ostium primum atrial septal defect), with or without atrioventricular valve repair Closure of aortico-left ventricular tunnel Complete repair of anomalous venous return (supracardiac, intracardiac, or infracardiac types) Repair of cor triatriatum or supravalvular mitral ring by resection of left atrial membrane Atrial septectomy or septostomy; closed heart (Blalock-Hanlon type operation) Atrial septectomy or septostomy; open heart with cardiopulmonary bypass Atrial septectomy or septostomy; open heart, with inflow occlusion Repair of transposition of the great arteries, atrial baffle procedure (eg, Mustard or Senning type) with cardiopulmonary bypass; Repair of transposition of the great arteries, atrial baffle procedure (eg, Mustard or Senning type) with cardiopulmonary bypass; with removal of pulmonary band Repair of transposition of the great arteries, atrial baffle procedure (eg, Mustard or Senning type) with cardiopulmonary bypass; with closure of ventricular septal defect Repair of transposition of the great arteries, atrial baffle procedure (eg, Mustard or Senning type) with cardiopulmonary bypass; with repair of subpulmonic obstruction Repair of transposition of the great arteries, aortic pulmonary artery reconstruction (eg, Jatene type); 33619 33641 33647 33660 33722 33730 33732 33735 33736 33737 33774 33775 33776 33777 33778 Repair of transposition of the great arteries, aortic pulmonary artery reconstruction (eg, Jatene type); with removal of pulmonary band 33779 Repair of transposition of the great arteries, aortic pulmonary artery reconstruction (eg, Jatene type); with closure of ventricular septal defect 33780 Repair of transposition of the great arteries, aortic pulmonary artery reconstruction (eg, Jatene type); with repair of subpulmonic obstruction Aortic suspension (aortopexy) for tracheal decompression (eg, for tracheomalacia) (separate procedure) Repair of hypoplastic or interrupted aortic arch using autogenous or prosthetic material; without cardiopulmonary bypass Repair of hypoplastic or interrupted aortic arch using autogenous or prosthetic material; with cardiopulmonary bypass 33781 33800 33852 33853 Page 5 of 10 Ascending aorta graft, with cardiopulmonary bypass, with or without valve suspension; with aortic root replacement using composite prosthesis and coronary reconstruction Ascending aorta graft, with cardiopulmonary bypass with valve suspension, with coronary reconstruction and valve-sparing aortic annulus remodeling (eg, David Procedure, Yacoub Procedure) Repair of thoracoabdominal aortic aneurysm with graft, with or without cardiopulmonary bypass Bypass graft, with other than vein, transcervical retropharyngeal carotidcarotid, performed in conjunction with endovascular repair of descending thoracic aorta, by neck incision Insertion of intra-aortic balloon assist device, percutaneous Removal of intra-aortic balloon assist device, percutaneous Insertion of intra-aortic balloon assist device through the femoral artery, open approach Removal of intra-aortic balloon assist device including repair of femoral artery, with or without graft Insertion of intra-aortic balloon assist device through the ascending aorta Removal of intra-aortic balloon assist device from the ascending aorta, including repair of the ascending aorta, with or without graft Unlisted procedure, cardiac surgery Open repair of infrarenal aortic aneurysm or dissection, plus repair of associated arterial trauma, following unsuccessful endovascular repair; tube prosthesis Open repair of infrarenal aortic aneurysm or dissection, plus repair of associated arterial trauma, following unsuccessful endovascular repair; aorto-bi-iliac prosthesis Open repair of infrarenal aortic aneurysm or dissection, plus repair of associated arterial trauma, following unsuccessful endovascular repair; aorto-bifemoral prosthesis Open iliac artery exposure with creation of conduit for delivery of infrarenal aortic or iliac endovascular prosthesis, by abdominal or retroperitoneal incision, unilateral Open brachial artery exposure to assist in the deployment of infrarenal aortic or iliac endovascular prosthesis by arm incision, unilateral Transluminal balloon angioplasty, open; aortic Transluminal peripheral atherectomy, open; aortic Transluminal peripheral atherectomy, percutaneous; aortic Bypass graft, with vein; carotid Bypass graft, with vein; carotid-subclavian Bypass graft, with vein; subclavian-carotid Bypass graft, with vein; carotid-vertebral 33863 33864 33877 33891 33967 33968 33970 33971 33973 33974 33999 34830 34831 34832 34833 34834 35452 35481 35491 35501 35506 35507 35508 Page 6 of 10 Bypass graft, with vein; carotid-carotid Bypass graft, with vein; carotid-brachial Bypass graft, with vein; subclavian-subclavian Bypass graft, with vein; subclavian-brachial Bypass graft, with vein; subclavian-vertebral Bypass graft, with vein; subclavian-axillary Bypass graft, with vein; axillary-axillary Bypass graft, with vein; axillary-femoral Bypass graft, with vein; axillary-brachial Bypass graft, with vein; brachial-ulnar or -radial Bypass graft, with vein; brachial-brachial Bypass graft, with vein; aortosubclavian or carotid Bypass graft, with vein; aortoceliac or aortomesenteric Bypass graft, with vein; axillary-femoral-femoral Bypass graft, with vein; splenorenal Bypass graft, with vein; aortoiliac Bypass graft, with vein; aortobi-iliac Bypass graft, with vein; aortofemoral Bypass graft, with vein; aortobifemoral Bypass graft, with vein; aortoiliofemoral, unilateral Bypass graft, with vein; aortoiliofemoral, bilateral Bypass graft, with vein; aortofemoral-popliteal Bypass graft, with vein; femoral-popliteal Bypass graft, with vein; femoral-femoral Bypass graft, with vein; aortorenal Bypass graft, with vein; ilioiliac Bypass graft, with vein; iliofemoral Bypass graft, with vein; femoral-anterior tibial, posterior tibial, peroneal artery or other distal vessels Bypass graft, with vein; popliteal-tibial, -peroneal artery or other distal vessels Harvest of femoropopliteal vein, one segment, for vascular reconstruction procedure (eg, aortic, vena caval, coronary, peripheral artery) (List separately in addition to code for primary procedure) Bypass graft, with other than vein; carotid Bypass graft, with other than vein; carotid-subclavian Bypass graft, with other than vein; subclavian-subclavian Bypass graft, with other than vein; subclavian-axillary Bypass graft, with other than vein; axillary-femoral Bypass graft, with other than vein; axillary-popliteal or -tibial 35509 35510 35511 35512 35515 35516 35518 35521 35522 35523 35525 35526 35531 35533 35536 35537 35538 35539 35540 35548 35549 35551 35556 35558 35560 35563 35565 35566 35571 35572 35601 35606 35612 35616 35621 35623 Page 7 of 10 Bypass graft, with other than vein; aortosubclavian or carotid Bypass graft, with other than vein; aortoceliac, aortomesenteric, aortorenal Bypass graft, with other than vein; splenorenal (splenic to renal arterial anastomosis) Bypass graft, with other than vein; aortoiliac Bypass graft, with other than vein; aortobi-iliac Bypass graft, with other than vein; carotid-vertebral Bypass graft, with other than vein; subclavian-vertebral Bypass graft, with other than vein; aortobifemoral Bypass graft, with other than vein; aortofemoral Bypass graft, with other than vein; axillary-axillary Bypass graft, with other than vein; aortofemoral-popliteal Bypass graft, with other than vein; axillary-femoral-femoral Bypass graft, with other than vein; femoral-popliteal Bypass graft, with other than vein; femoral-femoral Bypass graft, with other than vein; ilioiliac Bypass graft, with other than vein; iliofemoral Bypass graft, with other than vein; femoral-anterior tibial, posterior tibial, or peroneal artery Bypass graft, with other than vein; popliteal-tibial or -peroneal artery Bypass graft; composite, prosthetic and vein (List separately in addition to code for primary procedure) Bypass graft; autogenous composite, two segments of veins from two locations (List separately in addition to code for primary procedure) Bypass graft; autogenous composite, three or more segments of vein from two or more locations (List separately in addition to code for primary procedure) Placement of vein patch or cuff at distal anastomosis of bypass graft, synthetic conduit (List separately in addition to code for primary procedure) Reimplantation, visceral artery to infrarenal aortic prosthesis, each artery (List separately in addition to code for primary procedure) Limited lymphadenectomy for staging (separate procedure); pelvic and para-aortic Limited lymphadenectomy for staging (separate procedure); retroperitoneal (aortic and/or splenic) Ventricular puncture through previous burr hole, fontanelle, suture, or implanted ventricular catheter/reservoir; without injection Ventricular puncture through previous burr hole, fontanelle, suture, or implanted ventricular catheter/reservoir; with injection of medication or other substance for diagnosis or treatment 35626 35631 35636 35637 35638 35642 35645 35646 35647 35650 35651 35654 35656 35661 35663 35665 35666 35671 35681 35682 35683 35685 35697 38562 38564 61020 61026 Page 8 of 10 Creation of shunt; subarachnoid/subdural-atrial, -jugular, -auricular 62190 Creation of shunt; ventriculo-atrial, -jugular, -auricular 62220 Level IV - Surgical pathology, gross and microscopic examination Abortion - Spontaneous/Missed Artery, Biopsy Bone Marrow, Biopsy Bone Exostosis Brain/Meninges, Other than for Tumor Resection Breast, Biopsy, Not Requiring Microscopic Evaluation of Surgical Margins Breast, Reduction Mammoplasty Bronchus, Biopsy Cell Block, Any Source Cervix, Biopsy Colon, Biopsy Duodenum, Biopsy Endocervix, Curettings/Biopsy Endometrium, Curettings/Biopsy Esophagus, Biopsy Extremity, Amputation, Traumatic Fallopian Tube, Biopsy Fallopian Tube, Ectopic Pregnancy Femoral Head, Fracture Fingers/Toes, Amputation, Non-traumatic Gingiva/Oral Mucosa, Biopsy Heart Valve Joint, Resection Kidney, Biopsy Larynx, Biopsy Leiomyoma(s), Uterine Myomectomy - without Uterus Lip, Biopsy/Wedge Resection Lung, Transbronchial B 88305 Placement of visceral extension prosthesis for endovascular repair of abdominal aortic aneurysm involving visceral vessels, each visceral branch, radiological supervision and interpretation (List separately in addition to code for primary procedure) 0081T Internal mammary artery graft performed for primary, isolated coronary artery bypass graft procedure (CABG) 4110F Case ICD 9 codes (any of the below) Description Percutaneous angioplasty or atherectomy of precerebral (extracranial) vessel(s) Percutaneous angioplasty or atherectomy of intracranial vessel(s) Percutaneous transluminal coronary angioplasty [PTCA] or coronary atherectomy Closed heart valvotomy, aortic valve Other replacement of aortic valve Open heart valvuloplasty of aortic valve without replacement Single internal mammary-coronary artery bypass Repair of atrial and ventricular septa with prosthesis Repair of atrial and ventricular septa with tissue graft Other and unspecified repair of atrial and ventricular septa Total repair of certain congenital cardiac anomalies Repair of ventricular septal defect with tissue graft Other and unspecified repair of ventricular septal defect Bypass anastomosis for heart revascularization Aortocoronary bypass for heart revascularization, not otherwise specified Open chest coronary artery angioplasty Double internal mammary-coronary artery bypass Other bypass anastomosis for heart revascularization ICD 9 Code 00.61 00.62 00.66 35.01 35.22 35.11 35.15 35.5 35.6 35.7 35.8 35.62 35.72 36.1 36.10 36.03 36.16 36.19 Page 9 of 10 Other shunt or vascular bypass Aorta-renal bypass Aorta-iliac-femoral bypass Other (peripheral) vascular shunt or bypass Angioplasty or atherectomy of other non-coronary vessel(s) Percutaneous cardiopulmonary bypass Postsurgical aortocoronary bypass status Percutaneous transluminal coronary angioplasty, postsurgical status Mechanical complication due to coronary bypass graft 39.23 39.24 39.25 39.29 39.50 39.66 V45.81 V45.82 996.03 Case CPT codes = heart transplant (any of the below) Description Anesthesia for heart transplant or heart/lung transplant Heart-lung transplant with recipient cardiectomy-pneumonectomy Heart transplant, with or without recipient cardiectomy ICD-9 Code 580 33935 33945 Case Possible ICD 9 codes (any of the below) Description Atrial Fibrillation ICD-9 Code 427.31 Control ICD 9 codes (any of the below) Description Atrial Fibrillation ICD-9 Code 427.31 Atrial Fibrillation & Flutter Atrial Flutter 427.3 427.32 Page 10 of 10