8:30 AM - 5:00 PM Sunday June 22 Short Course 8:30 10:15 8:30 Wellman 126 R Survey Package Analyses for Two Phase Studies, with Applications in Epidemiology 8:30 10:15 8:30 Monday June 23 Wellman 234 Monday June 23 Session Title: Statistical Issues for Emergent Measurement Methods in Biomedical Research Session Organizer/Chair: Dean Billheimer 8:35 RNAseq: the Death Knell for Gene Expression Arrays? John C. Marioni, University of Chicago with Cristopher E. Mason, Matthew Stephens, and Yoav Gilad 8:35 Clustering and Case-Control Studies 9:00 Novel PCR-Based Methodologies in Biomedical Research Bonnie LaFleur, University of Utah with Dean Billheimer 9:00 Adaptive Functional Models for the Analysis of Recurrent Event Panel Data 9:25 A Statistical Model for Identifying Proteins Differentially Expressed Between Case and Control Group Based on Label Free LC-MS/MS Experiment Results Pei Wang, Fred Hutchinson Cancer Research Center 9:25 9:50 Statistical Issues in the Analysis of CHiP Experiments Measuring Nucleosome Occupancy Pei-Fen Kuan, University of Wisconsin with Dana Huebert, Audrey Gasch, and Sunduz Keles 9:50 Session Title: Models for Clustered Longitudinal and Case Control Studies Wellman 6 Session Organizer: Charmaine Dean Chair: Jerry Lawless Chris Wild, University of Auckland with Alastair J. Scott 8:30 10:15 8:30 T. Lumley, University of Washington and N. Breslow, University of Washington Monday June 23 Wellman 119 Contributed 1: Survival Analysis and Symmetric Distributions Chair: Danielle Harvey 8:35 A Truly Non-Parametric Proportional Hazards Model Lorenzo Trippa, MD Anderson Cancer Center with Peter Muller and Wesley Johnson Jason Nielsen, Carleton University 9:00 Another Look at the Mean Lifetime Based on Censored and/or Truncated Data Jong Kim, Portland State University Pairwise Likelihood Method for Clustered Longitudinal Data Leilei Zeng, Simon Fraser University with Grace Y. Yi, and Richard J. Cook 9:25 Percentage of Survival Variation Explained by a Continuous Marker Caixia Li, University of California, San Francisco with Ying Lu Random Mean Models for Clustered and Longitudinal Data Peter X. Song, University of Michigan with Peng Zhang 9:50 Peakedness Ordering in Symmetric Distributions Hari Mukerjee, Wichita State University with Hammou El Barmi Abstracts: Page 1 of 8 10:3512:20 10:35 Monday June 23 Wellman 234 Session Title: Connections between Bayesian and Frequentist Methods Session organizer: Adam Szpiro, Thomas Lumley, and Ken Rice Chair: Thomas Lumley 10:40 Model-Robust Bayesian Regression and the "Sandwich" Estimator Adam Szpiro, University of Washington with Ken Rice, and Thomas Lumley 11:05 On the Use of Prior Information for Flexibly Monitoring Group Sequential Survival Trials 11:30 11:55 10:3512:20 10:35 Monday June 23 Wellman 6 Student Competition 1: Genetic and Genomic Data Chair: Laura Cowen 10:40 Conditional Tests for Localizing Trait Genes Yanming Di, University of Washington with Elizabeth A. Thompson Daniel I. Gillen, University of California, Irvine with Sean Brummel 11:05 Reducing Noise in cDNA Microarray Images using Wavelet-Based LMMSE Estimator Frequency Model-Robustness and Bayesian Decision Theory Ken Rice, University of Washington 11:30 Bayesian Nonparametric Modeling for Well-Calibrated Location and Scale Inference with Skewed and Heavy-Tailed Data David Draper, University of California, Santa Cruz 11:55 10:3512:20 10:35 Monday June 23 Wellman 119 Contributed 2: Random and Mixed Models Chair: Mary Redman 10:40 Bivariate Skew-Normal Independent Linear Mixed Models with Applications to Dental Epidemiology Dipankar Bandyopadhyay, Medical University of South Carolina with Victor Lachos, Pulak Ghosh, and Elizabeth Slate Tamanna Howlader, Concordia University with Yogendra P. Chaubey 11:05 Model Selection under the Proportional Hazards MixedEffects Model Michael C. Donohue, University of California, San Diego with: Ronghui Xu, Anthony Gamst, Florin Vaida, and David P. Harrington A Nested Mixture Model for Protein Identification using Mass Spectrometry Qunhua Li, University of Washington with Michael MacCoss, and Matthew Stephens 11:30 Iterative Estimating Equations for Nonlinear Mixed Effect Models Lawrence Lee, University of California, Davis with Jiming Jiang Calculating Average Power for the Benjamini-Hochberg Procedure William Feser, University of Colorado Denver with Tasha E. Fingerlin, Strand J. Matthew, and Glueck H. Deborah 11:55 Modeling Multi-Center Survival Data - Some Simulation Results Daozhi Zhang, Daiichi Sankyo Pharma Development. Abstracts: Page 2 of 8 1:453:30 1:45 Monday June 23 Wellman 234 Session Title: SNPs and Association Studies Session Organizer: James Dai Chair: Haiyan Huang Hua Tang, Stanford University with Sophie Candille 1:453:30 1:45 Monday June 23 Wellman 6 Student Competition 2: ROC Curves and Longitudinal Data Chair: Laura Cowen 1:50 Regression Methods for Area Under the ROC Curve for Diagnostic Studies with Ordinal Data Kumar Rajan, University of Washington with: Xiao-Hua (Andrew) Zhou 1:453:30 1:45 Monday June 23 Wellman 119 Contributed 3: Biomarkers & Risk Prediction and Assessment Chair: 1:50 Borrowing Information Across Populations in Evaluating Risk Prediction Markers Ying Huang, Fred Hutchinson Cancer Research Center with Ziding Feng Dan Gillen 1:50 Genetic Association Studies in Heterogeneous Populations 2:15 Challenges in Genomewide Association Studies of Transplantation Complications Lue Ping Zhao, Fred Hutchinson Cancer Research Center with Sue Li, and John Hansen 2:15 A Semi-Parametric Regression Approach for Time-Dependent ROC Curves Adjusted for Covariates Nan Hu, University of Washington 2:15 Estimating Relative Accuracy in an Unpaired Postmarket Device Study with Incomplete Disease Assessment Todd Alonzo, University of Southern California 2:40 Hierarchical Modeling and Stochastic Variable Selection in the Analysis of Multiple SNPS in Genetic Association Studies David V. Conti, University of Southern California with Juan Pablo Lewinger, Lars Beckman, Jenny Chang-Claude, and Nadine Cremer 2:40 A Stochastic Modeling Approach in Longitudinal Data Analysis Li Zhu, University of California, Davis with Fushing Hsieh, Juan Li, Eric Chi 2:40 Accuracy of Probabilistic Model Based Classifications of Future Long Term Uninsured Coverage Status Steven Cohen, Agency for Healthcare Research and Quality with William Yu 3:05 SHARE: An Adaptive Algorithm to Select an Optimal Set of SNPs for Genetic Association James Dai, Fred Hutchinson Cancer Research Center with Michael LeBlanc, Nicolas I. Smith, Bruce Psaty, and Charles Kooperberg 3:05 Robust Joint Analysis of Longitudinal Measurements and Competing Risks Failure Time Data via Modeling of Multivariate Random Effects Covariances Xin Huang, University of California, Los Angeles with Gang Li, and Robert M. Elashoff 3:05 Dynamic Transitional Processes through Bayesian Variable Selection in Disease State Modeling David Engler, Brigham Young University with Brian Healy 3:505:00 3:50 Monday June 23 WNAR Presidential Address PLENARY SESSION Chair: John Neuhaus, WNAR President Introduction 1100 Social Science & Humanities 4:00 Making Sense of Life: History Processes through Multi-State Models Jerry Lawless, University of Waterloo Abstracts: Page 3 of 8 8:3010:15 8:30 Tuesday June 24 Wellman 234 Session Title: Expression and Sequence Analysis Session organizer: Haiyan Huang Chair: Hua Tang 8:35 Statistical and Computational Challenges in Gene Expression Studies Based on NextGeneration Sequencing Sandrine Dudoit, University of California, Berkeley 9:00 Identification of Differentially Expressed Gene Categories in Microarray Studies Using Multivariate Nonparametric Analysis 9:25 9:50 8:3010:15 8:30 Tuesday June 24 Wellman 6 Session Title: ShapeRestricted Inference Session organizer: Guenther Walther Chair: Debashis Paul 8:35 Investigation Modality of Time Series Wolfgang Polonik, University of California, Davis with Gabriel Chandler Dan Nettleton, Iowa State University with Justin Recknor, and James Reecy 9:00 On Restricted Likelihood Tests of Sampling Bias Jiayang Sun, Case Western Research University with Michael Woodroofe, and Tao Jin Computational Diagnosis by Querying Large-Scale Public Microarray Repositories Haiyan Huang, University of California, Berkeley with Chun-Chi Lu, and Xianghong Jasmine Zhou 9:25 Fast and Optimal Evaluation of Multivariate Scan Statistics Guenther Walther, Stanford University Importance Sampling of Word Patterns in DNA and Protein Sequences Nancy R. Zhang, Stanford University with Hock Peng Chen, and Louis HY Chen 9:50 Maximum Smoothed Likelihood Estimation Geurt Jongbloed, Delft University of Technology Abstracts: Page 4 of 8 10:3512:20 10:35 Tuesday June 24 Wellman 234 Session Title: High Dimensional Variable Selection and Shrinkage Methods Session organizer: Garreth James Chair: James Dai Yiyuan She, Stanford University 10:3512:20 10:35 Tuesday June 24 Wellman 6 10:3512:20 10:35 Tuesday June 24 Wellman 119 Contributed 4: Longitudinal Data Chair: Todd Alonzo Student Competition 3: Model Selection and Survival Analysis Chair: Laura Cowen 10:40 An Efficient Computational Approach for Prior Sensitivity Analysis and Cross-Validation Luke Bornn, University of British Columbia with Arnau Doucet, and Raphael Gottardo 10:40 Determination of Longitudinal Changes in Images: Optimum Suprathreshold Selection in a Permutation Cluster Test Ying Lu, University of California, San Francisco with Qian Zhou, Wenjun Li, Caixia Li, Bill Chu, John Kornak, Thomas Lang, and Jiqian Fang 10:40 Sparse Regression with Exact Clustering 11:15 Variable Inclusion and Shrinkage Algorithms Peter Radchenko, University of Southern California, Marshall 11:05 On Model Selection Consistency of Elastic Net Jinzhu Jia, University of California, Berkeley with Bin Yu 11:05 Longitudinal Assessment of Hearing Toxicity in a Phase III Clinical Trial to Prevent Sporadic Colorectal Adenomas Christine McLaren, University of California, Irvine with Wen-Pin Chen, Sharon Fujikawa-Brooks, Daniel L. Gillen, and Frank L. Meyskens Jr. 11:45 Fast Sparse Regression and Classification Jerome Friedman, Stanford University 11:30 Regularization and Variable Selection for Data With Interdependent Structures Lingmin Zeng, Purdue University with Jun Xie 11:30 Joint Modeling of Extended Hazard and Longitudinal Data Yi-Kuan Tseng, Graduate Institute of Statistics, NCU, Taiwan with JaneLing Wang 11:55 Estimation of Treatment Effect Under Nonproportional Hazards and Conditionally Independent Censoring Adam P. Boyd, University of Colorado Denver Health Sciences Program with Daniel L. Gillen, and John M. Kittelson 11:55 A Latent Transition Analysis of Overweight Children with Incomplete Data Saebom Jeon, Korea University and University of Washington with Sibel Sirakaya Abstracts: Page 5 of 8 1:452:40 1:45 Tuesday June 24 Wellman 234 Session Title: Causal Inference Methods for Clinical Trials Session organizer: Mary Redman Chair: Bryan Shepherd 1:50 Causal Subgroup Modeling in Cancer Clinical Trials Mary Redman, Fred Hutchinson Cancer Research Center 2:15 Quantifying Dose-Response for a Continuous Treatment in the Presence of Non-Compliance or Confounding Erica E. Moodie, McGill University with David A. Stephens 2:453:50 4:105:15 Tuesday June 24 PLENARY SESSION IMS Medallion Lecture Chair: Charles Kooperberg Tuesday June 24 1:452:40 1:45 Tuesday June 24 Wellman 6 Contributed 5: Measurement Error Chair: 1:50 Measurement Error Models with Dichotomized Mismeasured Predictors Loki Natarajan, University of California, San Diego 2:15 A Comparison of Multiple Imputation and Inverse Probability Weighted Estimation for Survival Analysis with Missing Covariates Lihong Qi, University of California, Davis with Ying-Fang Wang, and Yulei He 1:452:40 1:45 Tuesday June 24 Wellman 119 Contributed 6: Floods and Fish Chair: Ken Kopecky 1:50 Estimating Exploitation Rates of a Migrating Population of Yellowtail Flounders using Multi-State Mark-Recapture Methods Laura Cowen, University of Victoria 2:15 Mixture Methods for the Analysis of Flood Frequency Distributions Philip A. Yates, California State Polytechnic University, Pomona with John Grego Chris Drake Wellman 234 Introduction WNAR PLENARY SESSION 2:50 Convex Methods for Pattern Classification Peter Bartlett, University of California at Berkeley with Steven Arlot, Michael Jordan, Jon McAuliffe, and Mikhail Traskin Wellman 119 WNAR Business Meeting Abstracts: Page 6 of 8 8:3010:15 8:30 Wednesday June 25 Session Title: Statistical Methods for Flow Cytometry Data Wellman 234 Session Organizer: George Luta Chair: Lynn Eudey Byron Ellis, AdBrite Inc 8:3010:15 8:30 Wednesday June 25 Wellman 6 Session Title: Statistical Methods for Evaluating Vaccine Efficacy Session 8:35 Assessing Causal Effects in the Doomed Bryan Shepherd, Vanderbilt University 8:3010:15 8:30 Wednesday June 25 Wellman 119 Contributed 7: Smoothing and Other Statistical Models Chair: Hung Chen 8:35 Comparison of Functional Data Analysis Methods Tsui-Ling Chen, Arizona State University Organizer/Chair: Holly Janes 8:35 A Statistician Visits the Flow Lab 9:00 Automated Feature Extraction from Flow Cytometry Data Errol Strain, BD Technologies with Perry Haaland 9:10 Chop-Lump Tests for Vaccine Trials Dean Follmann, National Institute of Allergy and Infectious Disease with Mike Fay, and Mike Proschan 9:00 Application of Nonparametric Percentile Regression to Body Mass Index Percentile Curves from Survey Data Yan Li, National Cancer Institute with Barry I. Gaubard, and Edward L. Korn 9:25 Defining Immune Responses via Intracellular Cytokine Staining: Pitfalls and Possibilities Martha Nason, National Institute of Allergy and Infectious Diseases, NIH, with Michael Proschan 9:40 Assessing Surrogate Endpoints in Vaccine Trials with Case-Cohort Sampling and the Cox Model Li Qin, Fred Hutchinson Cancer Research Center with Peter Gilbert, Dean Follmann, and Dognfeng Li 9:25 Regression Splines for DoseResponse Data Chin-Shang Li, University of California, Davis with Daniel L. Hunt 9:50 Automated Gating of Flow Cytometry Data via Robust Model-Based Clustering Raphael Gottardo, University of British Columbia with Kenneth Lo, and Ryan Brinkman 9:50 Computational Methods and Diagnostics for Unified Regression Analysis of Bounded Data with Many Observations at the Boundary Yan Yang, Arizona State University with Douglas Simpson Abstracts: Page 7 of 8 10:3512:20 10:35 Wednesday June 25 Wellman 234 Session Title: Functional Approaches for the Analysis of Complex Biological Data Session Organizer/Chair: Hans Müller 10:40 Parameter Cascades: A Parameter Dictionary with an Estimation Strategy James Ramsay, McGill University 11:10 Biomarker Discovery for Proteomics and Genomics Data using Functional Mixed Models 11:40 12:10 10:3512:20 10:35 Wednesday June 25 Wellman 6 Contributed 8: Genes and Gene Expression Chair: Erica Moodie 10:40 Plot for Assessing InterSample Variability of Eigenvectors in PCA Hung Chen, National Taiwan University with IPing Tu Jeffrey Morris, the University of Texas MD Anderson Cancer Center 11:05 Modeling Dependent Gene Expression Generalized Varying Coefficient Models for Longitudinal Data Damla Senturk, Pennsylvania State University with Hans-Georg Müller 11:30 Kendall's Tau-Type Rank Statistics Invited Discussion Debashis Paul, University of California, Davis 10:3512:20 10:35 Wednesday June 25 Wellman 119 Contributed 9: Spatial Statistics and Imaging Chair: Martha Nason 10:40 Spatial Spectral … Myron Katzoff, Centers for Disease Control and Prevention Donatello Telesca, MD Anderson Cancer Center with Peter Muller, and Giovanni Parmigiani 11:05 An Exact Test to Detect Geographic Aggregations of Events Rhonda Rosychuk, University of Alberta with Jason L. Stuber Moonsu Kang, Virginia Institute of Psychiatric and Behavioral Genetics 11:30 A Comparison of Methods Used to Simulate a NeymanScott Process in Adaptive Cluster Sampling Research Philip Turk, Northern Arizona University with John Borkowski 11:55 Biologically Driven Data Reduction of Patterns of Change Seen on Structural Imaging Danielle Harvey, University of California, Davis with Laurel A. Beckett Abstracts: Page 8 of 8