University of Pennsylvania Health System
Department of Ophthalmology Scheie Eye Institute
T
S
L
G
LASS
Fall, 2004 Volume 5, Number 2
ON
ESSAGE
FROM THE
HAIR
Medical Student
Education
Resident Education
2-3
4-9
Fellowships 10-12
Post Doc &
Graduate Students 13-15
16-17 K12 Award
The 130th
Anniversary 18-19
Classes &
Visiting Professors 20-21
Ophthalmology
Review Course 22
Faculty
Lectures & Seminars
23
24 www.penneye.com
In previous issues of the Scheie Looking Glass, we have described the breadth and depth of our department’s clinical and research programs to highlight how we treat patients today and how our research may lead to better treatments tomorrow.
In this issue we portray our commitment to passing knowledge to the next generation of ophthalmologists and vision scientists.
Undergraduates and medical students, residents and fellows, graduate and postdoctoral students, research assistants and faculty – all teach and learn from one another.
A secret to our success in education is our enthusiasm for solving problems in ophthalmology and vision science and the thrill of giving our patients the benefit of discovery.
The opportunities to learn and make new discoveries about the gift of sight are limited only by our motivation and imagination. Penn Ophthalmology provides the rest.
2 • VOLUME 5, NUMBER 2
EDICAL
TUDENT
DUCATION
The eye is one of the most accessible organs of the body and can reveal early signs of systemic disease long before a patient experiences symptoms. It is surprising to discover that Penn is one of the few medical schools that requires a course in clinical ophthalmology. Several
Scheie faculty, in collaboration with ophthalmology faculty at other medical schools, are trying to remedy that situation. Prithvi Sankar, M.D.
, a member of the Glaucoma Service, serves as Director of Medical Student Education for Penn Ophthalmology.
At Penn, ophthalmology is introduced in the first year of medical school during the course on brain and behavior. After attending a lecture on the anatomy and function of the visual system, students proceed to the laboratory to dissect a cow eye. Faculty mentors supervise this activity.
During the second year, students in groups of ten are scheduled for a oneweek clinical clerkship. This clerkship introduces students to common eye problems, major causes of vision loss in the U.S. and in the world, and major unsolved problems in ophthalmology and vision science. A bonus is that students are exposed to our faculty, providing an interaction that often stimulates an interest in ophthalmology and eye research. The clerkship includes lectures, reading assignments, discussion of interesting cases, and participation in clinics and surgery with both faculty and residents.
In the third year, the department offers a one-month clinical elective during which students attend conferences, participate in clinics, observe in the operating room and meet with faculty several times a week to discuss special topics such as glaucoma, macular degeneration, cataracts, and diabetic retinopathy. This rotation allows for the acquisition of clinical skills such as measuring visual function, using special equipment, and examining the retina with an ophthalmoscope. In addition, students may work on short projects.
In the fourth year, a student can choose to spend from three months to a full year to pursue a research project that is often continued after completion of medical school if the student selects ophthalmology as a career. Three Penn
Medicine graduates from the Class of
2004 - Gena Heidary, Naureen
Mirza and Stacy Pineles , chose to follow this career path and describe their experiences at Scheie.
Prithvi Sankar, M.D., lectures to first-year Penn Medical
Students (first row, left to right) Danielle Darrah, James
Feinstein, Leisha Nolen, Laura Sheiman, Taral Patel,
(second row left to right) Jeremy Brauer
and Rebecca Nerenberg.
My ophthalmology experience at
Scheie consisted of a one-week introductory clerkship, a one-month elective which included rotations with many faculty and one-month of neuro-ophthalmology. The neuroophthalmology experience led to a four-month research project with
Nicholas J. Volpe, M.D.
Dr. Volpe and I created a fully automated, combined static and kinetic perimeter test to examine neuro-ophthalmic and glaucoma patients who had visual field defects. We also studied patients with functional visual loss. Our results were reported at the North
American Neuro-Ophthalmology
Society (NANOS) and Association for
Research in Vision and Ophthalmology (ARVO) meetings, and will appear as a brief report in the American Journal of Ophthalmology. We also are preparing a full-length manuscript that will provide more details about our results.
Besides helping me to complete this research project, Dr. Volpe was a generous advisor during my residency application process and helped me to choose programs that best met my needs and career plans. Drs. Fine and
Volpe, and all of the faculty and residents at Scheie, have created a truly nurturing environment for students interested in ophthalmology. After a one-year internship at Harbor-UCLA
Hospital, I will begin residency at the
Jules Stein Eye Institute at UCLA in July
2005.
Ophthalmology offered me an ideal mix of surgery and clinically driven research. Armed with a Ph.D. in Neuroscience and some expertise in both fly and human genetics, I anticipate focusing my career in ophthalmic genetics. My interests led me to the laboratory of Terri L. Young, M.D.
, a pediatric ophthalmologist and ophthalmic geneticist. Dr. Young’s lab identifies genes that may contribute to hereditary forms of severe nearsightedness or high myopia.
My project, performed in collaboration with Gui-shuang Ying, Ph.D.
, and Maureen G. Maguire, Ph.D.
, both at Scheie’s Center for Preventive Ophthalmology and Biostatistics, investigated the relationship between high myopia and astigmatism.
In severely myopic patients, we found a high prevalence of astigmatism, a relationship that had not been described previously. I presented the results at this year’s annual meeting of the Association for Research in Vision and Ophthalmology.
After completing a transitional internship at UPHS Presbyterian Medical Center, I will begin my residency in ophthalmology at the Massachusetts Eye and Ear Infirmary in July
2005.
THE SCHEIE LOOKING GLASS • 3
During my fourth year of medical school, I worked in the laboratory of
Michael J. Tolentino, M.D.
, whose research focuses on developing novel treatments for age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity. My project was to engineer ocular cells to produce a therapeutic protein and to control where and when the protein is produced. We constructed a virus that could commandeer ocular cells to produce a measurable gene product.
When fully developed, this system could be used to control delivery and to dose therapeutic molecules with a laser. While the majority of my work involved cell culture, a future direction will be to test the system in animals.
My laboratory experience convinced me that new therapies for devastating ocular diseases will be possible only through continued scientific research. I hope to be a part of such innovative medicine.
I will be a transitional intern for one year at Albert Einstein Medical Center in Philadelphia and will begin my residency at Scheie in July
2005.
4 • VOLUME 5, NUMBER 2
ESIDENT
DUCATION
Why do more than 400 senior medical students apply for Scheie’s five residency slots each year, making Scheie one of the most sought-after residencies in the country? Since the structure and curriculum of residency programs in the
U.S. are fairly standard, the people in the program make the difference. Students apply to Scheie because our faculty approach teaching with gusto.
Scheie’s program provides breadth and depth in comprehensive ophthalmology, retina and vitreous, glaucoma, neuro-ophthalmology, cornea and external diseases, oculoplastic, orbital and cosmetic eye surgery, pediatric ophthalmology and low vision services.
Our four main clinical facilities (Scheie Eye
Institute, Hospital of the University of
Pennsylvania (HUP), Children’s Hospital of
Philadelphia (CHOP) and the Philadelphia
Veterans’ Administration Medical Center
(VAMC)) offer a diversity of practice environments. Classroom instruction and practice surgery on animal eyes help residents develop confidence in their
Third year resident Linda Rose, M.D., Ph.D., shown performing surgery with
Stephen Orlin, M.D., says, “I value the quality of human contact which is a great backup to learning. There is such great diversity and contrast in faculty styles, yet everyone puts themselves out to help me learn.”
Second year resident B. Michael Walker, M.D., performs an eye exam with visiting medical student Allen Chiang from NYU.
THE SCHEIE LOOKING GLASS • 5
newly acquired skills. When a resident is inspired to focus on one particular aspect of ophthalmology, the opportunities for pursuing an exciting research project are numerous. In 2003, the Scheie residency received a full five-year accreditation, the best possible designation, by the
Accreditation Council of Graduate Medical
Education’s Residency Review Committee for Ophthalmology.
First year residents at Scheie learn to perform eye examinations, use ocular instruments and lenses, manage emergencies and perform microsurgery.
They rotate for ten weeks each on the cornea/glaucoma, retina, VAMC, HUP and pathology/oculoplastics services and share call duty with a senior resident and an attending physician for off-hour emergencies. Residents also may begin their first four-week elective to work on clinical or laboratory research projects.
Second year residents spend ten weeks each in pediatric ophthalmology at
CHOP, neuro-ophthalmology, retina/ vitreous, cornea/glaucoma and the VAMC.
Charles Nichols, M.D., Deputy Chief of Ophthalmology at HUP and third year resident
Jason Hsu, M.D., examine patients at HUP.
By the end of the second year, residents have been exposed to the full spectrum of comprehensive ophthalmology and its
David Kozart, M.D., Chief of the Comprehensive Ophthalmology Service and second year resident Newman Sund, M.D., Ph.D.
subspecialties and have performed both intra- and extra-ocular surgery with supervision. Most residents present
Continued on page 6
6 • VOLUME 5, NUMBER 2
Scheie’s Ophthalmology Residency Program Keeps The Future In Sight (Continued)
results from first year research projects at scientific and professional meetings.
Third year residents focus on honing their surgical skills and
managing post-operative patients.
They also have the unique opportunity to design a ten-week elective to satisfy their interest in a subspecialty, laboratory or international experience. Third year resident Wai Wong,
M.D., Ph.D.
, chose Scheie because “I enjoy basic science and
Scheie has a great research reputation and is strong in my areas of interest - retina and neuro-ophthalmology. The attending physicians treat us like colleagues and give us a nice balance of advice and the benefit of their experience.”
After three years, Scheie graduates are fully trained and ready to practice general ophthalmology or begin subspecialty fellowship training. In recent years most residents have chosen fellowships to prepare either for careers in academic ophthalmology or for private practice in a subspecialty.
Ophthalmologists in training may apply for support from the
Jenny Hall, M.D., second year resident, practices cutting and suturing cow eyes in the wet lab, which she says, “is a great way to get used to working with my hands and the tiny tools under the microscope.”
Thomas Heed
Ophthalmic Foundation which provides modest stipends on a
competitive basis. The
Heed Ophthalmic
Foundation awards are among the most
prestigious awarded to young
ophthalmologists who are planning a career in academic ophthalmology. Over the past three years, two applicants who have completed residencies at the Scheie Eye Institute finished first in the competition, thereby garnering the Society of Heed
Ophthalmic Fellows distinction. A third applicant received the only two year fellowship awarded by the Heed Foundation.
Our faculty and staff are proud of their accomplishments.
Third year resident Shane Kim, M.D., and
Michael Sulewski, M.D., at the Veterans Administration
Medical Center in front of the Korean War Memorial.
New
THE SCHEIE LOOKING GLASS • 7
A graduate of Princeton University, Cathy attended Washington
University School of Medicine in St. Louis, where she also earned a
Ph.D. in Molecular and Cellular Biology, studying phospholipid regulation of potassium channels. Cathy spent last year as an intern in the Presbyterian Transitional Program. She is an accomplished triathlete and flutist.
Stuart Fine, M.D. and
Catherine Cukras, M.D., Ph.D.
review retina photographs prior to examining a patient.
Cathy hails from Atlanta, GA and was graduated from Emory
University. She completed the Transitional Program at UPMC-
Presbyterian upon graduating from Penn Medical School. Cathy is an expert clarinetist, having performed with the Emory Wind Ensemble, the Atlanta-Emory Orchestra and the Atlanta Olympic Band.
Jason, a graduate of Amherst College, attended Penn Medical School and worked in the lab of Eric Pierce, M.D., Ph.D. studying mutations in the RP1 gene and their association with retinitis pigmentosa. Prior to completing the Presbyterian Transitional Program, Jason traveled to
Japan to study ophthalmology and Japanese language and culture as part of the Nagoya University
Program for Academic
Exchange.
Third year resident William
Katowitz, M.D., demonstrates how to use a gonioscope to
Catherine
Hwang, M.D.
Madhura was graduated from the University of Bombay, India where she also completed a residency in ophthalmology. She did research at
Wills Eye Hospital for two years before completing an internship in surgery at Yale University and a fellowship in Neuro-ophthalmology at
Penn/Scheie. Madhura enjoys river rafting with her husband and two children. Rumor has it that her culinary skills are superb.
Second year resident Wayne
Wu, M.D., Ph.D., and Jason Skalet,
M.D. review a patient’s chart.
A graduate of Duke University, Bob attended Penn Medical School and completed the transitional year program at Crozer-Chester Medical
Center. During his final year of medical school, Bob worked in the lab of Dr. Joshua Dunaief investigating mechanisms underlying age-related macular degeneration. Bob is an accomplished jazz musician and world traveler, having journeyed to
Hong Kong, Nepal and Peru.
Madhura Tamhankar,
M.D. administers drops to one of her patients.
Robert Wong, M.D.
(right) performs a slit lamp examination supervised by
Paul Tapino, M.D.
8 • VOLUME 5, NUMBER 2
Leonard Feiner, M.D., Ph.D.
, just began a two-year fellowship in vitreoretinal surgery at Barnes
Retina Institute, Washington
University, St. Louis, MO.
Len received a two year fellowship award from the Heed Ophthalmic
Foundation.
Michael Tracy, M.D.
, is performing a cornea fellowship at Bascom Palmer Eye Institute at the University of Miami.
Three residents from the Class of 2004,
Gabrielle Bonhomme, M.D.
,
Damon Chandler, M.D.
, and
Leila Khazaeni, M.D.
, chose to remain at Penn for their fellowships.
Please read about them in the fellowship article on page 10____.
Scheie’s leaders in education are not limited to its faculty and staff.
Gil Binenbaum, M.D.
, was selected to serve as the sole resident member of the
Residency Review Committee for
Ophthalmology (RRC), the group responsible for residency program accreditation in the United States.
Operating under the auspices of the
Accreditation Council for Graduate
Medical Education, the RRC is composed of ten members, (9 of the 10 are ophthalmologists) three each appointed by the American Academy of
Ophthalmology, the American Board of
Ophthalmology, and the American
Medical Association, and one current resident in ophthalmology. The committee establishes academic standards for all aspects of residency education and reviews each individual residency every two to five years to ensure compliance with those standards.
As resident member of the RRC,
Binenbaum will serve a two-year term and be a full-voting member of the committee. This appointment is a careerdefining opportunity for Binenbaum who is interested in medical education. He received his undergraduate degree from the Wharton School at Penn and had a successful career as a foreign exchange trader before returning to the University of Pennsylvania for medical school. At
Penn Med, he became active in curricular reform and began to set his sights on a career in academic ophthalmology. He plans eventually to become a residency program director, a goal towards which his work on the RRC should provide valuable experience.
THE SCHEIE LOOKING GLASS • 9
Nicholas J. Volpe, M.D.,
Residency Program Director , is largely responsible for the well-rounded format of the residency. Volpe’s interest in ophthalmic education began during his own residency and fellowship years at the Massachusetts Eye and Ear
Infirmary. He realized that he derived enormous satisfaction from interactions with residents in the clinic, operating room and classroom and by collaborating with them on projects. He also was struck by the fact that
“ophthalmic education often was left to chance.” Consequently, he decided early in his career that improving ophthalmic education would be an integral part of his professional future.
Volpe’s commitment to ophthalmic education extends to the national level.
He has led the surgical arm of the
American Board of Ophthalmology’s task force to develop methodologies for teaching and evaluating surgical competency. Along with other program directors, he organized and taught courses and symposia with the goal of improving all aspects of residency education. During the past year, he served as chair of the residency program directors division of the
Association of the University Professors of Ophthalmology (AUPO), and recently was named as the recipient of the prestigious Bradley R. Straatsma Award for Excellence in Resident Education.
Volpe attributes much of his success to the unwavering support he receives from department Chair Stuart Fine,
“who has allowed him to devote the time, effort and resources worthy of this important endeavor.”
Paul J. Tapino, M.D.
, was recently appointed as Deputy Residency
Program Director . In his role as
“COO” of the residency, Tapino is responsible for organizing lectures, clinical rotations, and attending schedules, orienting new residents, and teaching the basics of eye examinations.
Tapino also runs the inpatient consult service with the residents, teaches the residents in the clinic, operating room and classroom, and intervenes whenever problems arise.
Education Coordinator,
Jenny Bartelle orchestrates the dayto-day activities which run the gamut from reviewing residency applications, scheduling interviews, verifying credentials, creating and assembling materials for interviews, helping to organize the curriculum, providing documentation for medical student, residency and continuing medical education courses, and lending the occasional shoulder to cry on.
Institute Director Stuart L.
Fine, M.D.
is committed to providing the support needed for the best possible residency experience. Fine,
Volpe, Tapino and Bartelle meet with the resident group monthly to obtain feedback and to discuss potential improvements.
Scheie Education Leadership from left to right:
Paul Tapino, M.D., Prithvi Sankar, M.D.,
Nicholas Volpe, M.D., Jenny Bartelle and Stuart Fine, M.D.
10 • VOLUME 5, NUMBER 2
ELLOWSHIPS
HINA AHMED, M.D., GLAUCOMA FELLOW
Hina was graduated from Dartmouth College. She attended Wright State
University School of Medicine and completed her residency in ophthalmology at
Case Western Reserve University. Hina looks forward to the clinical, surgical and teaching challenges that await her. We welcome her back East!
GABRIELLE BONHOMME, M.D., NEURO-OPHTHALMOLOGY FELLOW
Gabrielle, a Washington, D.C. native, is no stranger to the Penn/Scheie community. She was graduated from Penn Medical School and completed the residency program at Scheie in June 2004. In her free time, Gabrielle enjoys running, playing the piano and spending time with her family.
Ophthalmologists who want to subspecialize in a particular area must undergo one to two years of additional training. Penn offers fellowships in glaucoma, neuro-ophthalmology, oculo-plastic surgery, pediatric ophthalmology, medical retina, and vitreoretinal diseases and surgery. Each fellowship provides indepth clinical and research experience in the fellow’s chosen area. Fellows interact closely with clinical faculty, vision scientists, residents, and medical students. They attend both general conferences and subspecialty conferences and typically engage in clinical and/or basic research during the course of the fellowship.
DAMON CHANDLER, M.D., OCULOPLASTICS FELLOW
Damon spent 8 years at Duke as an undergraduate and medical student followed by a General Surgery internship at Massachusetts General Hospital.
He too is a recent graduate of the Scheie residency program and will be the first
Oculoplastics fellow working with Dr. Roberta Gausas. Art history, classical music, and racquetball keep Damon busy when not at Scheie.
LEILA KHAZAENI, M.D., PEDIATRIC OPHTHALMOLOGY FELLOW
Leila, another of the 2004 Scheie residency graduates, received her medical degree from University of Michigan where she also completed her internship. She is an avid marathon runner and completed the NY Marathon this year. Keep an eye out for her along the Kelly and West River Drives!
Damon Chandler, M.D.
and Roberta Gausas, M.D.
prepare to do surgery.
Our department’s fellowship programs offer strong clinical, surgical, and research training. The fellows gain exposure from working in several hospitals and are exposed to many clinical and research faculty.
The continuum of education from medical students to residents to fellows is one of the great strengths of the Scheie Eye Institute.
MELANIE MCCARTY, M.D., OCULOPLASTICS FELLOW
Melanie was graduated from University of Alabama School of Medicine. She completed her internship at Baptist Hospital Systems in Birmingham and residency at University of Tennessee Health Science Center. She enjoys running, eating and lots of shopping.
Hina Ahmed, M.D., responds to a message from a patient.
Gabrielle Bonhomme, M.D. and
Nicholas Volpe, M.D. review a CAT scan.
THE SCHEIE LOOKING GLASS • 11
George Mayo, M.D. and
Alexander Brucker, M.D. review a fluorescein angiogram.
STEFANIE DAVIDSON, M.D.
Stefanie completed her training in pediatric ophthalmology and has joined the faculty at CHOP.
Carolyn Glazer-Hockstein, M.D.
with Joshua Dunaief, M.D., Ph.D.
HEATHER (FOGT) DEALY, M.D.
Heather joined the
Brandywine Eye
Center in
Wilmington, DE after completion of a glaucoma fellowship at Scheie.
CAROLYN GLAZER-HOCKSTEIN, M.D., MEDICAL RETINA
Carolyn completed her residency at Scheie. As the current medical retina fellow, she works closely with the retina faculty in the clinic, learning the spectrum of retinal pathology. She also has completed coursework in medical epidemiology.
According to Glazer-Hockstein, “the medical retina fellowship at Scheie is different because the fellow examines patients with all the retina faculty, not just medical retina.”
GEORGE MAYO, M.D.
, VITREORETINAL SURGERY
Geroge, a Penn medical graduate and lieutenant commander in the United States
Naval Reserve, completed a residency in San Antonio, Texas prior to becoming the vitreo-retinal surgical fellow. He participates actively in the busy operating room and the clinics at Scheie. He also helps to run the VA retina clinical and surgical services under the supervision of Robert Stoltz, M.D., Ph.D.
Melanie McCarty, M.D. and
Jim Katowitz, M.D.
FEMIDA KHERANI, M.D.
Femida returned home to her native Canada after completing her training in oculoplastics and is joining a group practice in Calgary,
Alberta.
Leila Khazaeni, M.D. (right) and Monte Mills, M.D.
KENNETH SHINDLER, M.D., PH.D.
Kenneth joined the
Scheie neuroophththalmology faculty as a clinicianscientist following the completion of a oneyear neuroophthalmology fellowship.
12 • VOLUME 5, NUMBER 2
GLAUCOMA OCULOPLASTICS
• 1 year
• Preceptors:
Jody R. Piltz-Seymour, M.D.
Eydie G. Miller-Ellis, M.D.
Prithvi S. Sankar, M.D.
• Clinical Research
Ocular Hypertension
Treatment Study
(OHTS)
NEURO-
OPHTHALMOLOGY
Collaborative Initial
Glaucoma Treatment
Study (CIGTS)
Memantine trial
Corneal thickness in juvenile glaucoma
Long-term visual fields survival in advanced glaucoma
• 2003-2004 Fellow:
Heather Dealy, M.D.
• 2004-2005 Fellow:
Hina Ahmed, M.D.
• 1 year: fellows must have completed residency in either ophthalmology or neurology
• Preceptors:
Nicholas J. Volpe, M.D.
Steven L. Galetta, M.D.
Dina Jacobs, M.D.
Grant T. Liu, M.D.
Laura Balcer, M.D.
Kenneth S. Shindler,
M.D., Ph.D.
• Clinical Research
Optic neuritis
Visual fields
Computerized
Goldmann perimetry
Adult strabismus surgery
Pupillometry
Clinical trials in MS
• 2003-2004 Fellow:
Kenneth S. Shindler,
M.D., Ph.D.
• 2004-2005 Fellow:
Gabriel Bonhomme,
M.D.
• www.upno.org
• 2 year ASOPRS approved fellowship
• Preceptor:
James A. Katowitz, M.D.
• Principal venues CHOP,
HUP, VAMC, outside practices
• Clinical Research
Orbital volumetric studies
Fetal surgery and wound healing
Comparison of various synthetic materials in ptosis repair
Orbital and socket expansion with hydrogel in congenital microphthalmia
Genetic relationships in congental microphthalmia
• 2003-2004 Fellow:
Femida Kherani, M.D.
• 2004-2005 Fellow:
Melanie McCarty, M.D.
• 1 year fellowship
• Preceptor Roberta E.
Gausas, M.D.
• Principal venues SEI,
HUP, VAMC, outside practices
PENN
• 2004-2005 Fellow:
Damon Chandler, M.D.
• Both fellowships include extensive rotations at
HUP and CHOP in
Plastic Surgery, ENT,
Maxillo-facial Surgery,
Trauma, Dermatology,
Neurosurgery, and
Neuroradiology
PEDIATRICS
• 1 year
• Intend to offer 2 positions in 2005-2006
• Preceptors:
Monte D. Mills, M.D.
Graham E. Quinn, M.D.
Brian J. Forbes, M.D.
Eric A. Pierce, M.D., Ph.D.
Terri L. Young, M.D.
Stefanie Davidson, M.D.
• Clinical Research
Prevention of progressive myopia
Ophthalmic genetics
Multi-center clinical trials
Vision impairment in preschoolers
Strabismus
Amblyopia therapy
Electrophysiology
Retinopathy of prematurity
• 2003-2004 Fellow:
Stefanie Davidson, M.D.
• 2004-2005 Fellow:
Leila Khazaeni, M.D.
RETINA
• Medical Retina -
1 year full-time,
2 years part-†time
• Medical Retina and†
Vitreoretinal Surgery -
2 years
• Preceptors:
Alexander J. Brucker, M.D.
Joshua L. Dunaief, M.D.
Stuart L. Fine, M.D.
Juan E. Grunwald, M.D.
Leonid E. Lerner, M.D., Ph.D.
Albert M. Maguire, M.D.
Robert A. Stoltz, M.D, Ph.D.
• Clinical Research
• Multi-center clinical trials in diabetic retinopathy and
AMD
• Pathogenesis of AMD
• 2003-2005
Medical Retina Fellow:
Carolyn Glazer-Hockstein, M.D.
• 2003-2005 Medical and
†Vitreoretinal Surgery Fellow:
George Mayo, M.D.
THE SCHEIE LOOKING GLASS • 13
OST
OC
RADUATE
TUDENTS
Discovering and developing treatments and cures for devastating eye diseases requires years of painstaking research. Budding young scientists carry out much of this work while furthering their education. For the post doctoral, graduate and undergraduate students working with the Penn Ophthalmology vision scientists, learning is exciting and fun.
It’s not your typical day in the laboratory of Jean Bennett, M.D., Ph.D.
,
Professor of Ophthalmology and a Senior
Scientist in our department’s F.M. Kirby
Center for Molecular Ophthalmology .
Post doctoral fellow and now Research
Assistant Professor, Nadine Dejneka, Ph.D.
, called Bennett with an emergency. A mother mouse that had just given birth to a litter of lysosomal enzyme-deficient mice, died and the babies would not survive without her. But Bennett knew the trick – get another nursing mother mouse to urinate on the surviving litter, and she would accept them as her own.
In the highly complex world of vision research, sharing information at every level is the key to success. Dejneka joined the Bennett lab six years ago as a post doc and was appointed as Research
Assistant Professor in July 2004. Dejneka,
Enrico Surace, D.V.M.
and colleagues were the first to show that in utero gene therapy could be used therapeutically to treat an inherited retinal disorder in mice.
Dejneka designs her own experiments and has published numerous papers on gene therapy. Her work is focusing on using adeno-associated virus to permanently modify mutations in retinal genes. According to Dr. Bennett, “Nadine has superb technical and presentation skills and is an incredible teacher.”
Tonia Rex, Ph.D.
, came to the
F.M. Kirby Center three years ago as a post doc on an NIH training grant in gene therapy to work in the Bennett laboratory. A.k.a. “T. Rex,” Bennett describes her as a “dynamo” because she loves science and her enthusiasm is contagious. Her project, gene therapy for
Stargardt’s Disease, allows her to use her broad knowledge to quantify proteins in retinal cells, deliver corrective genes to mouse models, work with viral vectors, and test the efficacy of therapies. Her special talent is immunohistochemical techniques, particularly in dealing with problem tissue samples. Rex also has given seminars at the Penn and Jefferson campuses. She collaborates with Scheie scientists Edward Pugh, Ph.D. and
Samuel Jacobson, M.D., Ph.D.
Her goal is to combine teaching with research in an academic career. She devotes
Saturday mornings to teaching disadvantaged kids in North Philadelphia.
Jeannette Bennicelli, Ph.D.
, a molecular biologist working at Penn since
1978, is interested in defining the mechanisms underlying retinal degenerative diseases, in particular, focusing on the role of an EFEMP1 gene mutation in Malattia Levantinese and
Doyne Honeycomb Retinal Dystrophy.
Although these inherited diseases are rare, they have phenotypic features in common with Age-Related Macular
Degeneration (AMD), the leading cause of severe and irreversible vision loss in the
United States. Elucidation of the pathogenic mechanism involving mutated
EFEMP1 may give insight into the cause of
AMD. Bennicelli plans to apply for an NIH grant in February to continue her studies of EFEMP1.
After more than 20 years of cancer research, Bennicelli’s move to Bennett’s lab two years ago was a huge career change. “I enjoy applying my skill set to an entirely new set of questions and problems. The extensive resources available in the F.M.
Kirby Center have allowed me to apply the latest technologies to my research.
I also enjoy the opportunities afforded by the Center to interact with colleagues and to teach and mentor post
Continued on next page
14 • VOLUME 5, NUMBER 2 docs and students in the lab.”
When not in the lab, Bennicelli usually can be found riding or hanging out at
Chamounix Equestrian Center with her daughter Dana. She is a Board member at
Chamounix and a volunteer of the Work to Ride program that serves disadvantaged youth from Southwest
Philadelphia.
Nick Keiser, B.A.
, is a fourth-year graduate student and Ph.D. candidate, originally from upstate New York. He is working on the cellular and biochemical basis of inherited retinal disease and specifically on the cause of choroideremia.
His goal is to develop reagents to treat this disease and test them in an animal model. He plays the trombone in his spare time.
Daniel C. Chung, D.O.
, completed a pediatric ophthalmology fellowship in
2003 at the Cleveland Clinic and has been in the Bennett laboratory for 10 months.
He works on establishing non-viral methods of gene transfer into mouse retinal structures for future use in possible gene therapy studies, assists in maintaining the animal colonies, and performs subretinal injections on mice and other surgical techniques as needed by his colleagues in the lab. As a trained pediatric ophthalmologist with an interest in gene therapy, his ultimate goal is to become a clinician-scientist. He says, “I enjoy the concept of finding possible therapies for eye diseases that currently have no treatment, through gene manipulation techniques. Dr. Bennett promotes an atmosphere in which I am most productive.” Outside the lab, he spends most of his time with his three children, all under age 6. He loves, but rarely has time for, outdoor and wildlife photography.
Hal Schwartzstein , an undergraduate at Penn working at the F.M.
Kirby Center for the past year, assists the research scientists with their experiments.† This fall he will perform an experiment which consists of studying the progression of retinal degeneration in a new mouse model as part of an independent study class for his biology major.† He plans to attend medical
school in 2006 with the ultimate goal of specializing
in ophthalmology. He says, “ The F.M.
Kirby Center allows me to apply my coursework to relevant experiments and to pursue my interest in ophthalmology.”
Outside of the lab, he participates in student government as the Senior Class
Vice President of Corporate Sponsorship, enjoys intramural sports and is an active member of the Phi Kappa Psi fraternity.
Tatyana Metelitsina, M.D.
, completed her ophthalmology residency at The Filatov Research Eye Institute in
Odessa, Ukraine and came to the
U.S. in 2000 to pursue her interest in eye research. She is working as a post doctoral fellow under
Juan E. Grunwald, M.D.
, in the
Vivian Simkins Lasko Retinal
Vascular Research
Laboratory at Scheie.
Metelitsina and Grunwald have been working on a five-year project funded by the NIH to study choroidal blood flow in patients with AMD. The goal is to learn how choroidal blood flow in patients with AMD differs from blood flow in healthy eyes and how it changes with time and different interventions. Other studies in the pipeline are looking at ways to improve choroidal blood flow with pharmacological agents. Metelitsina
Tatyana Metelitsina and Juan Grunwald.
contemplated a career as a ballerina, but is happy she chose ophthalmology and would like to take care of patients someday.
THE SCHEIE LOOKING GLASS • 15
Qin Liu, M.D., Ph.D.
, came to the U.S.
6 years ago from Beijing where she practiced ophthalmology and earned her
Ph.D. in molecular biology. She has been conducting research with Eric Pierce,
M.D., Ph.D.
, at the F.M. Kirby Center for Molecular Ophthalmology for
5 years. Her project is to identify functions of the RP1 protein and to understand how mutations in the RP1 protein cause vision loss. One way of identifying
functions of the RP1 protein is to find candidate
– Qin Liu, M.D., Ph.D.
proteins whose functions are already known and that interact with RP1 and then to deduce RP1’s function from them using a technique called co-immunoprecipitation.
Liu characterizes her job at the F.M.
Kirby Center as “fun,” and says, “You find one thing and keep going and you open a new door to a new discovery.”
Liu spends her spare time with her 13year old daughter. She was recently promoted to Research Associate and plans to continue in research, although sometimes when doing surgery on animals, she misses taking care of people.
Bertrand Deramaudt, Ph.D.
, hails from Strasbourg, France and has been at the F.M. Kirby Center since November
2001. Deramaudt’s research focuses on pre-RNA processing factor 8 protein
(PRPF8), which is expressed in every tissue in the body. A mutation in the gene makes the protein abnormal and can lead to a form of retinitis pigmentosa, but no harm elsewhere in the body. Deramaudt is designing several versions of a mouse model with the almost identical PRPF8 protein found in humans. In the “knockin” version, the gene mimics the disease in people; in the “knock-out” version, the gene is missing. The goal is to understand how the protein functions. Deramaudt spends his free time with his wife, who is expecting their second child, and his 5year old son.
Sara Achenbach, B.A.
, is a third year graduate student on the Pierce team. Her project, tied closely with that of Qin Liu, is to identify proteins that interact with RP1.
Achenbach uses a yeast-2 hybrid, has identified several candidate proteins and is confirming their identity in animal models. Achenbach loves teaching and wants, “to convey the excitement of biology to young people.” Outside the lab, she teaches aerobics and enjoys crocheting and swimming.
John Graziotto, B.S.
, is a fourth-year graduate student working on identifying the function and creating mouse models for the PRPF3 protein in similar fashion to
Bertrand Deramaudt’s work on PRPF8.
PRPF3’s normal function is required for
RNA splicing; Graziotto wants to know how the protein causes disease when mutated. He hopes to start a laboratory someday to conduct research on neurological diseases such as Alzheimer’s
– Anna Bracewell and Parkinson’s. He works long hours, but when not working, enjoys playing the piano and going out with friends.
Anna Bracewell was graduated from
Penn with a B.A. in music theory and composition, but decided to change course and attend medical school. She takes science classes in the evenings and works the rest of the time on Eric Pierce’s projects as “Eric’s hands in the lab.” She values the collaboration at the
F.M. Kirby Center ; “The most pleasurable and unique thing about working in a lab is having the chance to reason through problems with intelligent people.” Not surprisingly, she spends her spare time as a musician: singing and playing the violin and piano.
Anna Bracewell, Eric Pierce, Sara Achenbach, John Graziotto,
Qin Liu and Bertrand Deramaudt
16 • VOLUME 5, NUMBER 2
New
In May 2004, the National Eye Institute awarded one of three prestigious K-12 Awards to support the Penn Vision Clinical Scientist Program.
Created in recognition of the fact that clinical and patient-oriented research should be conducted by a multidisciplinary research team, the NEI and
Penn Ophthalmology are committed to preparing young investigators to conduct research using this approach.
In May 2004, the National Eye Institute (NEI) awarded one of three prestigious K-12 Awards (technically called the
Institutional Mentored Clinical Scientist Development
Awards) to support the Penn Vision Clinical Scientist
Program (VCSP). Both the K-12 Award and the Penn VCSP were created in recognition of the fact that clinical and patient-oriented research have become increasingly more complex and often require a systems approach conducted by a multidisciplinary research team. The NEI and Penn
Ophthalmology are committed to preparing young investigators to conduct research using this approach.
The K-12 is different from other NEI training awards in that it grants Penn the freedom to choose individual recipients, subject to final NEI approval.
The Penn VCSP will be anchored in the Department of
Ophthalmology. Maureen G. Maguire, Ph.D.
, the
Carolyn Jones Professor of Ophthalmology and the
Director of the Center for Preventive Ophthalmology and
Biostatistics, is the principal investigator. Laura J. Balcer,
M.D., Jean Bennett, M.D., Ph.D., Stuart L. Fine, M.D.,
Graham E. Quinn, M.D., and Edward N. Pugh, Ph.D.
, serve on the Advisory Committee. These and other established investigators will serve as mentors to guide the choices that the VCSP physician-scientists make in their educational programs and research projects. Mentors also
THE SCHEIE LOOKING GLASS • 17 advise mentees on activities necessary for professional development, collaboration among investigators, and development of long-term research programs. Lead mentors, either from the rich pool of talent within the department or from other Penn departments that have close ties to vision science, will be matched to each participant by area of interest. The Advisory
Committee will meet periodically with the VCSP participant and his/her mentor to discuss progress and to set goals and priorities.
The VCSP will take advantage of established educational programs within the university, the concentration of strong clinical and patient-oriented research programs currently ongoing within the Department of Ophthalmology, and the breadth of expertise available through Penn’s interdisciplinary institutes and centers. After completion of the VCSP, physician-scientists will be prepared to identify and prioritize important questions in their field, formulate a comprehensive approach to address the questions, and lead the efforts of a research team to provide answers.
Candidates selected for the
VCSP will have access to formal educational programs and applied research experience in a wide array of areas such as clinical epidemiology, singlecenter and multi-center clinical trials, health services research, bioethics, genetics, molecular biology, and neuroscience. Each year, one or two recently trained clinicians will be selected for participation in the VCSP.
Established investigators in clinical and patient-oriented research will serve as mentors to guide the choices made by VCSP participants in educational programs and research projects, as well as advise them on activities necessary for professional development, collaboration among investigators, and developing successful research programs.
All training programs incorporate the following common features:
• A didactic program of instruction
• Participation in journal clubs, lab meetings, and seminar series
• Development of a plan of research activities that provides a variety of experiences and an increasing amount of responsibility and independence
• Development of oral presentation and writing skills and other professional skills
• Regular review of the candidate’s plans and activities with evaluation and feedback provided to the participant
With our department’s commitment to recruit exceptionally well trained clinicians who are also prepared to conduct scientific research
(patient-oriented or laboratory),
Penn’s VCSP goes a long way towards maintaining our position as one of the outstanding eye institutes in the world. During each of the next
2 years, the department would like at least one of its K12 awardees to be focused on epidemiology or clinical research in the clinical disciplines of cornea, glaucoma, pediatric ophthalmology, or ocular oncology.
VCSP
The first VCSP participant is Andras
Komaromy, Dr.med.vet., Ph.D.
Although at first glance, the choice of a veterinarian may seem odd for a Clinician Scientist award, a quick look at Komaromy’s past training and research experience, as well as his research goals, shows that he is exactly the sort of person for whom the VCSP was designed. His strong interest in comparative ophthalmology and vision science began while a veterinary student in Switzerland. He completed a residency and Ph.D. program in comparative ophthalmology (pathogenesis of glaucoma in animal models) at the
University of Florida where he simultaneously developed a strong interest in retinal biology and electrodiagnostics that led him to a fellowship with Gus Aguirre, V.M.D.
, a veterinary ophthalmologist at the Penn School of Veterinary Medicine. Komaromy believes that animal models of inherited retinal diseases are an important link in understanding disease in man.
During the next 5 years, he will be refining his knowledge of retinal cell and molecular biology and of the fine points of electrophysiologic testing under the guidance of lead mentor
Aguirre and co-mentors Jean Bennett, M.D.,
Ph.D
and Samuel G. Jacobson, M.D., Ph.D.
18 • VOLUME 5, NUMBER 2
The
The annual alumni meeting was held in the Scheie Auditorium on May 21 and May 22. The featured guest speakers were Donald L. Budenz,
M.D., Associate Professor of
Ophthalmology at Bascom Palmer Eye
Institute and Daniel F. Martin, M.D.,
Professor of Ophthalmology at Emory
University. On Friday evening, May 21 a dinner dance was held at the Four
Seasons in honor of alumni from the classes of 1954, 1964, 1974, 1984 and
1994. Stuart L. Fine, M.D.
introduced and listed the many accomplishments of each honoree and presented them with a “Philadelphia,
Then and Now” book to commemorate the occasion. The faculty and staff were thrilled to meet many returning alumni and to hear directly what they have been doing since completing residency. We look forward to even greater alumni participation at the
2005 alumni meeting which will be held on May 20 and 21, 2005, with the evening event on May 20, 2005, again at the Four Seasons Philadelphia.
Harvey
Brown was instrumental in getting the class of 1974 to attend.
Lawrence Handler
Class of 1974 with their spouses are clockwise from front: Elliott and Jane Yolles, Harvey and Roanna Brown, Kay-Lee and Lai-Sung Eric Leung, Bonnie Kay, Carl Lindquist, Mike Kay and Julie Lindquist.
Thomas John
Douglas Young
THE SCHEIE LOOKING GLASS • 19
1954
Melvin G. Alper, M.D.
Anthony M. Spirito, M.D.
1964
Milton M. Connell, M.D.
Dugald H. Munro, M.D.
Herbert J. Nevyas, M.D.
Bernard Schneider, M.D.
1974
Harvey Allen Brown, M.D.
Smith F. Hogsett, M.D.
Michael L. Kay, M.D.
Lai-Sung Eric Leung, M.D.
Carl W. Lindquist, M.D.
Elliott A. Yolles, M.D.
1984
Kenneth V. Cahill, M.D., F.A.C.S.
Thomas John, M.D.
Randolph L. Johnston, M.D.
Jane G. Schweitzer, M.D.
Jerry C. Weinberg, M.D.
Allan E. Wulc, M.D., F.A.C.S.
1994
David W. Day, M.D.
Alyson L. Hall, M.D.
Lawrence F. Handler, M.D.
Neil S. Kalin, M.D.
Eileen R. Lilley, M.D.
Joseph D. Napolitano, M.D.
Dean P. Ouano, M.D.
Bruce Robert Saran, M.D.
Douglas A. Young, M.D.
The
20 • VOLUME 5, NUMBER 2
ECTURES
EMINARS
These educational forums provide an opportunity for the ophthalmologists intraining as well as the faculty to exchange ideas, share research findings and educate each other concerning state-of-the-art knowledge in vision research and clinical ophthalmology.
The Visiting
Professor Program
Visiting professor Susan B. Bressler, M.D. with
Robert Stoltz, M.D., Ph.D. and Carolyn Glazer-Hockstein, M.D.
A wealth of lectures, research seminars, conferences, visiting professorships and continuing medical educational (CME) courses remains an integral component of Scheie’s educational mission. These activities include: brings 10-15 distinguished clinicians and scientists for oneand-a-half days each year. The visit begins early Wednesday evening when the visiting professor is the guest of honor at a small dinner gathering attended by several faculty and house staff. On Thursday morning, the visiting professor participates in Ophthalmology
• A daily lecture and weekly conference series for residents and medical students (see calendar below)
• Weekly research meetings and journal clubs in each of the ophthalmic subspecialties
• A visiting professor series
• An ophthalmic heritage lecture series
Grand Rounds before delivering the first formal presentation. After the morning lecture, our guest visits with selected faculty and is escorted to a number of our special resource centers.
A noon seminar provides a relaxed forum for discussion between the visiting professor, clinical faculty, vision scientists
• Three commemorative lectures
• CME courses highlighted by our twoday annual alumni meeting in May.
and house staff. After lunch, the visiting professor may spend time with the
Department Chair and additional faculty.
Clinical
Pathology
Conferences
As scheduled
Neuro-
Ophthalmology
7-8:00 (1st)
Basic Science
Lectures
7-10:00
Fluorescein
Angiography
Conference
7-8:00
Retina
Conference
7:30-8:30
(1st, 2nd and
5th)
Glaucoma
Conference
(3rd)
7-8:00
Retina
Journal Club
(4th)
7-8:00
Grand
Rounds
7-7:45
Visiting
Professor
Series
7:45-8:30
Cornea
Conference
7-8:00
(1st)
First-year students meet with Deputy
Rsidency twice per month
As Scheduled
The Visiting Professor Program has been successful, not only in bringing outstanding speakers to the department, but also in educating distinguished ophthalmologists and vision scientists about our department, residency, and research activities. Our expectation is for the visiting professor not only to leave a mark upon our Institution and staff but also to serve as an ambassador for our department wherever he or she may travel.
The Ophthalmic Heritage Lecture
Series focuses on how eye diseases and treatment have affected art, politics and society historically. The inauguration of this lecture series in 2003 acknowledges the Cogan Ophthalmic History Society, a national organization of some 50 ophthalmologists who meet annually to review our treasured ophthalmic history.
The series was inaugurated so that our house staff and faculty could better appreciate the major contributions made by giants in ophthalmology and vision science.
Commemorative lectureships honor faculty who have made outstanding contributions to Penn ophthalmology. The
Francis Heed Adler Lecture is named for the fourth department chair who served from 1935-1960. Dr. Adler was a secretary of the American Board of Ophthalmology, a noted physiologist and author, and a recognized national leader in organized ophthalmology. The Jeffrey Berger
Memorial Lecture was named for an exceptionally talented young physicianscientist whose untimely passing in 2001 left an enormous void in the department.
Dr. Berger was a member of the Retina
Service and the Director of the Computer
Vision Laboratory. The Louis Karp
Memorial Lecture acknowledges contributions made by a busy clinical practitioner who (despite his role as Chief of Ophthalmology at the Pennsylvania
Hospital), came weekly to Scheie to deliver a one-hour lecture to the residents on the ophthalmic pathology service. Each year a recognized expert in ophthalmic pathology is invited to deliver this lecture.
Three or four times a year, the department sponsors a weekend
THE SCHEIE LOOKING GLASS • 21 continuing medical education course in a particular subspecialty. The course is taught by invited guest speakers and by Scheie faculty and staff.
Traditionally the weekend begins on Friday afternoon, when the visiting professor presents interesting cases to the residents. On Friday evening, there is typically a social function. Saturday morning features a clinically oriented conference followed by a discussion of interesting cases. These CME courses provide an opportunity for members of the department and the surrounding ophthalmic community to discuss current information about patient care and relevant clinical research.
The highlight of the academic year is the Annual Meeting in May that includes a two-day continuing medical education course. Invited guest speakers as well as medical students, residents, faculty and alumni present topics on their current clinical and research interests.
During the two-day course, one evening is devoted to a social function (typically with dinner and dancing) at one of the premier Philadelphia hotels during which time alumni returning for a special anniversary are honored. Friends of the
Scheie Eye Institute, donors to the department’s programs, the University of
Pennsylvania Health System leaders, and
Chairs from other Penn Med departments are invited to attend this celebratory event.
This year in March of 2005 the department will inaugurate the Penn
Ophthalmology Review Course, a comprehensive review of ophthalmology for residents and for ophthalmologists around the country who may be preparing to take the American Board of
Ophthalmology written qualifying examination. The course will be taught in part by Penn Ophthalmology faculty and in part by five distinguished professors from outstanding programs across the country. Nicholas J. Volpe is the course director. For further information, contact Jenny Bartelle at 215-662-8069 or jenny.bartelle@uphs.upenn.edu.
Sander
Dubovy,
M.D.
, gave the 2004
Louis Karp
Lecture.
Visiting professor
Elias I.
Traboulsi, M.D.
Thomas A.
Weingeist,
Ph.D., M.D., gave the 2004
Francis Heed
Adler Lecture.
Joel S. Schuman, M.D.
, the featured speaker at the Glaucoma CME in
February 2004, is shown with
Prithvi Sankar, M.D. and
Jody Piltz-Seymour, M.D.
William S. Tasman, M.D.
,
(pictured in photo above to the left) presented an
Ophthalmic Heritage lecture titled Eye
Disorders and How
They Affect History and the Arts and showed a painting, “A Self
Portrait,” by Edvard
Munch as seen through the eyes of the artist who suffered from macular degeneration.
22 • VOLUME 5, NUMBER 2
NICHOLAS J. VOLPE, M.D.
N
N
E
P
O
PH
Retina
Oconology
LO
Glaucoma
Catarct/Cornea
Oculoplastics/Orbit
IE
V
Y
G
R
E
SE
Optics/Refraction
Retinal Degeneration
Comprehensive Ophthalmology
Pediatrics/Strabismus
Refractive Surgery
Neuro-Ophthalmology
UR
Pathology
Uveitis
CO
W
University of Pennsylvania Health System
THE SCHEIE LOOKING GLASS • 23
U
P
D
O
PUBLICATIONS
COMMITTEE
STUART L. FINE, M.D.
Chairman, Director and Editor
NICHOLAS J. VOLPE, M.D.
Vice Chair Clinical Practice
Residency Program Director
CHERYL ATKINS-LUBINSKI
Vice Chair and
Chief Operating Officer
JENNY BARTELLE
Coordinator, Educational Activities
MEG MACFARLANE
Manager, Administrative Services
MAUREEN G. MAGUIRE, Ph.D.
Professor of Ophthalmology
FRANCIS J. MANNING, M.D.
President of the Alumni
Association
ANN SACKS
Director of Development and
Alumni Relations
Photography by
Bill Nyberg and Jim Berger
L
S
CTOBER
TO
UNE
Visiting Professor Lectures are on Thursdays:
7:45-8:30 AM • Scheie Eye Institute Auditorium-Lower Level
Noon-1:00 PM • Thayer Conference Room, SEI 5th Floor
OCTOBER 7, 2004
C. P. Wilkinson, M.D.
Greater Baltimore Medical Center
JANUARY 6, 2005
Samuel G. Jacobson, M.D., Ph.D.
Scheie Eye Institute/
University of Pennsylvania
MARCH 8-12, 2005
Penn Ophthalmology
Review Course
Hyatt Regency Philadelphia at
Penn’s Landing OCTOBER 14, 2004
Jeffrey Berger
Memorial Lecture
Donald Zack, M.D., Ph.D.
Johns Hopkins University
JANUARY 13, 2005
Tomas S. Aleman, M.D.
Scheie Eye Institute/
University of Pennsylvania
MARCH 31, 2005
Stuart Seiff, M.D.
University of California, San Francisco
NOVEMBER 11, 2004
Juan E. Grunwald, M.D.
Scheie Eye Institute/
University of Pennsylvania
JANUARY 20, 2005
Stuart J. McKinnon, M.D., Ph.D.
University of Texas
APRIL 14, 2005
Joshua L. Dunaief, M.D., Ph.D.
Scheie Eye Institute/
University of Pennsylvania
NOVEMBER 18, 2004
Louis Karp Memorial Lecture
W. Richard Green, M.D.
Johns Hopkins University
NOVEMBER 20, 2004
Neuro-ophthalmology of
Optic Neuritis & Multiple
Sclerosis
8:00 am - 12:00 noon
JANUARY 22, 2005
Jamie Brandt, M.D.
University of California, Davis
FEBRUARY 3, 2005
Barrett Haik, M.D.
University of Tennessee, Memphis
FEBRUARY 10, 2005
Eydie Miller-Ellis, M.D.
Scheie Eye Institute/
University of Pennsylvania
FEBRUARY 12, 2005
Francis Heed Adler Lecture
Dan B. Jones, M.D.
Cullen Eye Institute/
Baylor College of Medicine
8:00 am - 12:00 noon
APRIL 21, 2005
Creig S. Hoyt, M.D.
University of California, San Francisco
MAY 12, 2005
Albert S. Jun, M.D., Ph.D.
Johns Hopkins University
MAY 20-21, 2005
131st Anniversary Meeting
Honoring Alumni from 1955, 1965,
1975, 1985, 1995 DECEMBER 2, 2004
Jonathan C. Horton, M.D., Ph.D.
University of California,
San Francisco
DECEMBER 9, 2004
Artur V. Cideciyan, Ph.D.
Scheie Eye Institute/
University of Pennsylvania
JUNE 2, 2005
Brian J. Forbes, M.D., Ph.D.
Scheie Eye Institute/
University of Pennsylvania
Children’s Hospital of Philadelphia
FEBRUARY 17, 2005
Terri Young, M.D.
Scheie Eye Institute/
University of Pennsylvania
Children’s Hospital of Philadelphia
JUNE 9, 2005
R. Doyle Stulting, M.D., Ph.D.
Emory University DECEMBER 16, 2004
David W. Parke, II, M.D.
Dean McGee Eye Institute/
University of Oklahoma
For more information, please contact
Marilyn Katz at 215-662-8657 or email katzm@uphs.upenn.edu
NON PROFIT
ORGANIZATION
U.S. POSTAGE
P A I D
PERMIT NO. 2563
PHILA. PA 19104 Department of Ophthalmology
Scheie Eye Institute
Comments, suggestions?
Please write, fax or e-mail to:
Ann Sacks
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
Phone: 215-662-8774
Fax: 215-662-1721
Email: ann.sacks@uphs.upenn.edu
To remove name from mailing list, call above number.