BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Hannah Hoeun Lee
MSTP Trainee
eRA COMMONS USER NAME (credential, e.g., agency login)
HANNAHHOEUN
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Cornell University, Ithaca, NY
BS
2002-2006
Chemical and Biomolecular
Engineering
A. Personal Statement
As an MD/PhD student in Bioengineering, I have great interest in basic and translational clinical research on
cartilage degeneration and regeneration. The central goal of my current research project is to investigate various
adeno-associated virus (AAV)-mediated approaches for cartilage tissue engineering. Using AAVs encoding for
various reporter gene, our group has extensively characterized the localization and persistence of the transgene
expression within the intact knee joint following a single intra-articular injection of the AAV in vivo. We also have
investigated different dilutions of fibrin glue for its function as AAV-releasing scaffolds in vitro. Various anabolic
and catabolic gene encoding AAVs were also assessed for their ability to promote chondrogenesis of
mesenchymal stem cells or to prevent excessive cartilage extracellular matrix molecules.
B. Positions and Honors
2003
Undergraduate Student Scholar, University of Pennsylvania School of Medicine
2004-2005 Visiting Undergraduate Researcher, Seoul National University School of Engineering
2004-2006 Undergraduate Researcher, Cornell University School of Chemical and Biomolecular Engineering
2005
Undergraduate Student Scholar, University of Pennsylvania School of Medicine
2005-2006 Undergraduate Researcher, Cornell University School of Chemical and Biomolecular Engineering
2006-2007 Undergraduate Student Scholar, University of Pennsylvania School of Medicine
Academic and Professional Honors
2002-2006 Dean’s List, Cornell University
2004
Engineering Learning Initiative Research Award, Cornell University,
2006
BS, Cum Laude, Cornell University
2008
Charles Claude Guthrie Award for Excellence in the Basic Medical Sciences, University of Pittsburgh
2009
Lars Peterson Basic and Translational Science Young Investigator Award, ICRS
2009
George M. Bevier Fellowship, University of Pittsburgh
2010-2012 CATER (Cellular Approaches to Tissue Engineering and Regenerative Medicine) Fellowship,
University of Pittsburgh
C. Selected Peer-reviewed Publications
Research papers:
Guo, R.J., Funakoshi, S., Lee, H., Kong, J., Lynch, J.P., “The intestine-specific transcription factor Cdx2 inhibits
β-catenin/TCF transcriptional activity by disrupting the β-catenin/TCF protein complex,” Carcinogenesis, 31 (2):
159-66, 2010. PMID: 19734199.
Abstracts:
Lee, J., Lee, H., Jang, E., Lee, S., Kim, S.J., “Photo-Triggering of the Membrane Gates in Photo-Responsive
Polymer for Drug Release,” 27th Annual International Conference of the IEEE Engineering in Medicine and
Biology Society (EMBS), Shanghai, China, 2005.
Lee, H., Harris, L., Clancy, P. “Stochastic Modeling of the Chemotaxis Signal Transduction Network in E.Coli,”
Cornell Engineering Learning Initiative Spring Poster Session, Ithaca, NY, 2006.
Lee, H., Payne, K.A., Qiao, C., Xiao, X., Chu, C.R., “ADAMTS-5 Antisense Sequence and Gene Delivery by AAV
to Rat Articular Chondrocytes for Chondroprotection,” 55th Annual Meeting of the Orthopaedic Research Society
(ORS), Las Vegas, NV, 2009.
Chu, C.R., Coyle, C.H., Lee, H., Payne, K.A., Seshadri, V., Karpie, J.C., Szczodry, M., Pringle, E.K., “In vivo
Effects of Single Intra-Articular Injection of 0.5% Bupivacaine on Articular Cartilage,” 55th Annual Meeting of the
Orthopaedic Research Society (ORS), Las Vegas, NV, 2009.
Payne, K.A., Martins, C., Lee, H., Xiao, X., Chu, C.R., “Localization and Persistence of Transgene Expression
Following Intra-Articular Injection of Adeno-Associated Virus into the Rat Knee,” 12th Annual Meeting of the
American Society of Gene Therapy (ASGT), San Diego, CA, 2009.
Lee, H., Payne, K.A., Haleem, A., Martins, C., Xiao, X., Chu, C.R., “Intra-Articular Persistence and Localization
of Transgene Expression Following a Single Injection of Adeno-Associated Virus into the Intact and Injured Rat
Knee Joints,” 56th Annual Meeting of the Orthopaedic Research Society (ORS), New Orleans, LA, 2010.
Payne, K.A., Lee, H., Haleem, A.M., Martin, C., Xiao, X., Chu, C.R., “Localization, Persistence, and Control of
Transgene Expression Following a Single Intra-Articular Injection of Adeno-Associated Virus into the Intact Rat
Knee Joint,” 9th World Congress of the International Cartilage Repair Society (ICRS), Barcelona, Spain, 2010.
(Poster Award)
Lee, H., Haleem, A.M., Yao, V., Chu, C.R., “Dilution of Fibrin Glue Affects Release of Adeno-Associated Virus:
Implications in Gene Delivery for Cartilage Tissue Engineering.” 57th Annual Meeting of the Orthopaedic
Research Society (ORS), Long Beach, CA, 2011.
Oral Presentations:
Lee, H., Payne, K.A., Qiao, C., Xiao, X., Chu, C.R., “Chondroprotection of Rat Articular Chondrocytes by
ADAMTS-5 Antisense Sequence and Gene Delivery by AAV,” 8th World Congress of the International Cartilage
Repair Society (ICRS), Miami, FL, 2009.
Payne, K.A., Lee, H., Haleem, A.M., Martin, C., Xiao, X., Chu, C.R., “Single Intra-Articular Injection Results in
Stable and Controllable in vivo Transgene Expression,” Osteoarthritis Research Society International (OARSI)
2010 World Congress on Osteoarthritis, Brussels, Belgium, 2010.
Payne, K.A., Lee, H., Haleem, A.M., Martin, C., Xiao, X., Chu, C.R., “Single Intra-Articular Injection of
Adeno-Associated Virus Provides Stable and Controllable Transgene Expression,” 57th Annual Meeting of the
Orthopaedic Research Society (ORS), Long Beach, CA, 2011.
Publications prior to 2007 are cited as Lee, Hoeun.
D. Research Support
Ongoing Research Support
T32 EB001026
Bowser (PI)
09/01/10-08/31/12
“Training program in cellular and tissue engineering and regenerative medicine (CATER)”
Role: Trainee