2010 Annual Report RESEARCH OUTREACH ADVOCACY 3 The Hepatitis B Foundation has enjoyed one of its most productive years despite the economic downturn. We are pleased to report that our work has been a bright spot in one of the toughest years. This year we have focused our efforts on making the greatest impact on some of the greatest unmet needs. This includes establishing consensus recommendations for hepatitis B screening and treatment of children who live with this disease and for primary care providers who lack clear guidelines. Research results take longer, but we have impressive and tangible results to share, too. This year, the liver cancer biomarker that we helped to discover has been optioned to a major diagnostics company. If all goes well, this blood test will be available for human use within the next couple of years. RESEARCH IN THE LABS YEAR IN REVIEW Financial Information* (Fiscal Year 2010 ending June 30, 2010) Sources of Funds – HBF & IHVR Combined (Total $4,322,068) Grants 84% $3,649,257 Charitable Contributions 11% $475,492 Interest >1% $3,157 Other 4% $194,162 So, if this is what we can accomplish in a tough year, it has only got to become easier! Thanks to all of you for your continued support, donations and confidence in our mission. Sincerely, Building for a Cure HBF’s groundbreaking for the expansion of its research facility to build nine new labs, which includes a teaching lab, represented a bright spot during a tough economy. Funding for the $1.4 million renovation project was provided in part by the HBF and its research organization, the Institute for Hepatitis and Virus Research, and Univest. Research $2,222,270 56% LIVING SCIENCE • Biomarkers of liver cancer enter advanced option development with Abbott Diagnostics (Block et al) • Biomarkers of liver fibrosis are good enough to advance to testing in 15,000 people with Johns Hopkins University in an NIH-funded study (Mehta et al, in progress) Uses of Funds – HBF & IHVR Combined • New drug (alkylated porphoryn) discovered that inactivates HBV, HCV, & HIV without harming mammalian cells (Guo et al, submitted 2010) Outreach and Education 21% (Norton et al, Hepatology 2010) $834,920 • Liver carcinoid drug successfully completes Phase II human studies (Shailubhai et al, in progress with Callisto, Inc.) Joel D. Rosen, Esq. Chairman of the Board • New pathway of HBV DNA synthesis discovered (Guo et al, Journal of Virology 2009) • Primabody, marker of infectious disease, • Glucovir drug enhances immune attack validated in animal studies against hepatitis B in woodchucks (Chen/Romano et al, in preparation) (Total $4,028,054) Timothy M. Block, Ph.D. President and Co-Founder (New Jersey) Public Health 4% $188,538 Supporting Services 5% PA state senator Chuck McIlhinney (3rd from $210,400 right) and PA Congressman Patrick Murphy (2nd to right) and PA state representatives General and Administrative 14% $571,926 Marguerite Quinn (center) and Kathy Watson (right) joined HBF to lend their support at (Cuconati et al, in progress) • Urine DNA test for colorectal cancer and • New glucovir compound protects animals polyps and liver cancer gets major award from Dengue disease (Chang et al, submitted 2010) from the Coulter Foundation (Su et al) • Human gene products discovered that repress hepatitis B, C and other viruses (Guo et al, Journal of Virology 2009) • Serum micro arrays can represent 8,000 different people on a single small “chip” (Chen et al, in progress) our groundbreaking ceremony at the PA Biotechnology Center (Jan 2010). HBF manages and co-owns the Center, which it created in * This audited financial information includes revenue and expenses from HBF and its research institute IHVR, but excludes the Foundation’s 50% ownership (or $6.9 million) in the PA Biotechnology Center valued at $13.8 million as per audited statements. • Liver cancer drug to be tested in animals 2006 to accelerate its research mission. HBF’s research is conducted in partnership with Drexel University College of Medicine, whose labs are located at our Biotech Center. Hepatitis B Foundation 2010 Annual Report Dear Friends, “We appreciate [the HBF’s] continued support of the Hep B community. With the addition of a second adopted child with hep B into our family, we obviously are supportive of your efforts in research and education.” 4 5 International HBV Meeting 2009 Bruce Witte Lecturer 2010 Board of Directors Biotechnology Faculty Chairman William Kinney, PhD Mohan Philip, PhD, MBA Joel Rosen, Esq. In a special ceremony at the state Capital, PA Governor Ed Rendell announced new grant awards to support the important work of research groups that included the HBF and its research institute – the Institute for Hepatitis and Virus Research (IHVR) – which is led by HBF/IHVR president Dr. Timothy Block (far left). (June 2010) HBF coordinates this prestigious international scientific meeting each year that attracts hundreds of researchers from around the world to discuss the science of hepatitis B and D viruses. This year the meeting was held in the beautiful Loire Valley in France. 2009 Meeting co-chairs Dr. Camille Sureau (France) and Dr. Stephen Locarnini (Australia) model the unique HBV ties given by HBF at the concluding banquet dinner. (Oct. 2009) TRAINING YOUNG SCIENTISTS “Working as a young scientist is a unique experience. Many doors of opportunity have opened for me and to others like me in the [HBF labs]. We are encouraged to be unafraid in our insights, and to realize that every new discovery comes from both standing on the shoulders of giants and from pioneering new ideas.” Anne Lamontagne, former Research Apprentice now in graduate school. Summer College Research Internships provide a wonderful (and paid) opportunity for students to work on an independent research project with senior scientists for a 10-week period. Funding is provided by grants from the PA Department of Health, Merck’s West Point Charitable Contributions Committee, and the Charles Sigety Family Foundation. The High School Enrichment Program offers a two-week “hands-on” experience in a professional lab for students entering their senior year. Interactive seminars led by leaders in the field introduce them to careers in science, medicine, patent law, public health and more. This program is supported in part by Pennsylvania EITC funds received from Universal Health Services of Delaware and Wal-Mart Stores, Inc. The Apprenticeship Program is designed for the recent college graduate who wants to gain real-life research experience before making a decision to pursue graduate or medical education. They receive valuable mentorship and encouragement to become deeply involved in their research projects and to participate in the intellectual world of scientists through research rounds, journal clubs, and special seminars. President Timothy Block, PhD Vice President W. Thomas London, MD Treasurer R. Donald Leedy, MBA Secretary Janine Witte Dr. T. Jake Liang (left), from the National Institutes of Health, gave the 9th Annual Bruce Witte Lecture about “Choreographing the Tango between Hepatitis C Virus and Cells by Functional Genomic Screen.” The lecture series was established by HBF co-founders Paul and Janine Witte. (April 2010) HBF Distinguished Scientist Award 2010 Dr. R. Palmer Beasley (center), accompanied by his wife and research collaborator Dr. Lu Yu Wang, received the Distinguished Scientist Award from HBF president Dr. Timothy Block (left) and Nobel Laureate Dr. Baruch Blumberg (right) at the Crystal Ball for his seminal HBV research conducted in Taiwan that identified mother-to-newborn transmission and the fatal link to primary liver cancer. He served as Chair of the National Academies Institute of Medicine (IOM) committee that published in January 2010 the first IOM report on “Hepatitis and Liver Cancer”. (April 2010) Joan M. Block, RN, BSN Thomas Block Stanley Broadbent Alan Brownstein, MPH Sandra Budinsky James Datin Kimberly Jungkind, RN, MPH Dale Kindregan Charles Sigety, Esq. Gurney Sloan, Esq. Catharine Williams, MGA Robert Zivin, PhD Medical and Scientific Advisors Harvey Alter, MD Timothy Block, PhD Baruch Blumberg, MD, PhD Carol Brosgart, MD Nathaniel Brown, MD Raymond Dwek, D Phil, FRS Lawrence Friedman, MD Robert Gish, MD Hie-Won L. Hann, MD W. Thomas London, MD William Mason, PhD Brian McMahon, MD Kenneth Rothstein, MD Raymond Schinazi, PhD Bud Tennant, DVM Senior Research Faculty Songming Chen, PhD Andrea Cuconati, PhD Surendra Dheer, PhD Sergey Ilyin, PhD Ramila Philip, PhD David Ren, MD, PhD Patrick Romano, PhD Thomas Russell, PhD Kunwar Shailubhai, PhD, MBA James Thacker, PhD Michael Xu, PhD Adjunct Research Faculty These Drexel U. research faculty members work at our research center and are supported in part by HBF/IVHR funds Jinhong Chang, MD, PhD Mary Ann Communale, MS Yanming Du, PhD Alison Evans, ScD Haitao Guo, PhD Ju-Tao Guo, MD Xuanyong Lu, PhD Anand Mehta, D.Phil Tulin Morcol, PhD Brad Nefsky, PhD Pamela Norton, PhD Allen Reitz, PhD Ying-Hsiu Su, PhD Executive Director Joan M. Block, RN, BSN Chief Business Officer Nelson Carvalho, MBA Director of Programs Margaret Farley, MBA Director of Accounting Patti McAloon, MBA Director of Operations/IT Konrad Kroszner Outreach and Public Health Nina Baltierra Gang Chen, MD, PhD Chari Cohen, MPH (DrPh candidate) Jackie Corwell Richard Kahn, MPH Kelly La (MPH candidate) Loretta Molle Lauren Nonini Hepatitis B Foundation 2010 Annual Report State Recognition for HBF Research 6 7 Thank you to all of the individuals and organizations that have generously supported the Hepatitis B Foundation. We truly appreciate everyone who has contributed to advancing our Cause for a Cure! BENEFACTORS’ SOCIETY $1000 – $10,000 and more Visionary Circle $10,000 and more Gunst Charitable Trust Kahn Charitable Foundation Universal Health Services of Delaware Global Circle $5,000 - $9,999 Timothy and Joan Block Joseph Potz and Pam Norton Charles Reynolds and Katharine Holloway Tulchin Family Foundation Founders’ Circle $2,500 - $4,900 Bugajewski Facility Services CCG Metamedia High Swartz, LLP W. Thomas and Linda London Research Triangle Institute Univest Wal-Mart Stores, Inc. President’s Circle — $1,000 - $2,499 AIG Matching Grants Program Amper, Politziner & Mattia, LLP Bank of America United Way Campaign Begley, Carlin & Mandio, LLP Stanley and Gerri Broadbent Faith Calhoun Delaware Valley College Discovery Chicago Drexel University College of Medicine Esterly Family of The Pittsburgh Foundation Fox Rothschild, LLP Glenmede Trust Company Matt and Anne Greene Hawai’i Community Foundation Grace John R. Donald and Martha Leedy Robert Loughery Anand and Valerie Mehta Microsoft Giving Campaign Pharmabridge Plumbline Construction Quakertown National Bank Joel and Nancy Rosen Claire Signs Bud Tennant University City Science Center University of the Sciences Richard Slabinski Brian Wigdahl Kyan Win Paul and Janine Witte Worth & Company “I would love to be able to contribute millions if I could! Your organization has been a huge help to me and my family and I have taken the B-Informed newsletter with me to doctor’s visits to make sure he had the most current information.” (Maine) HBF established this year the PA Center for Drug Discovery (PCDD) as an innovative program of its research institute, the Institute for Hepatitis and Virus Research, to accelerate the translation of biomedical discoveries into therapies for clinical evaluation in humans. Our PCDD program encompasses activities to improve efficiencies in early drug discovery research and to help integrate senior scientists back into the workforce who have been laid-off from companies that have downsized during the tough economy (we call this our “Up and Out” program which has been well-received). B Informed Now! Breaks the Barriers HBF revamped its annual patient conference into a mobile event that touched down on both U.S. coasts in Philadelphia and Los Angeles, with Seattle, WA slated to round out the 2010 itinerary. The B Informed Now! Patient Workshops on hepatitis B and liver cancer attracted almost 200 people at each site and offered free HBV screenings as well. Featured keynote speakers included Drs. Emmett Keeffe (Stanford U), Hie-Won Hann (Thomas Jefferson U), and Kenneth Rothstein (Drexel U). Sessions were offered in English with headsets provided for live translations into Chinese and Korean. Podcasts of the workshops are now available in all three languages on our website @ www.hepb.org. OUTREACH IN THE COMMUNITY (California) Hepatitis B The Philadelphia Story On June 15, 2010, HBF launched Hep B Free Philadelphia, a public health campaign based on the successful model in San Francisco. Hep B Free aims to increase screening and vaccination rates through a citywide mobilization effort. HBF’s campaign also returns hepatitis B to the forefront in Philadelphia, which has been at the center of the hepatitis B story from the very beginning. The hepatitis B virus was discovered by HBF’s Distinguished Scholar Dr. Baruch Blumberg (for which he won the Nobel Prize) at Fox Chase Cancer Center in Philadelphia, and he invented the hepatitis B vaccine that is now manufactured by two companies located in the region. The first animal discovered to be most useful in studying hepatitis B was an infected groundhog living at the Philadelphia Zoo. And the only national nonprofit dedicated to this disease, the Hepatitis B Foundation, was established in Philadelphia as well. Making the Rounds HBF continues to make an impact on clinical practice through its specialty workshops. The pediatric HBV workshops we convened to focus on children has resulted in the first national recommendations for their care and treatment; and this year’s workshop with leading primary care providers (PCPs) established recommendations for hepatitis B in busy primary care settings. All of the HBF clinical workshops were facilitated by HBF medical advisors Drs. Brian McMahon and Thomas London. A Social (Networking) Butterfly Twitter @hepbfoundation HBF has entered the dawn of a new era where technology and human connections have been blended to create the ultimate interactive experience — Social Media Networking. We are joining the global conversation, so please log on to our new social media venues to keep in touch! Facebook: www.facebook.com/hepbfoundation YouTube: www.youtube.com/hepbfoundation Linkedin: www.linkedin.com/companies/hepatitis-b-foundation Hepatitis B Foundation 2010 Annual Report CALENDAR YEAR 2009 DONATIONS “Your website has been an invaluable tool for my family, and we thank you for helping us in our treatment of the disease.” Drug Discovery Takes Center Stage 8 9 CALENDAR YEAR 2009 DONATIONS (continued) Ambassadors’ Circle — $500 - $999 Amgen Foundation Matching Gifts Victor Araya Artemis Solutions Chistopher and Catherine Asplen Clement and Choi Seung Au Bricker, Landis & Hunsberger, LLP Bridgepoint Insurance Group Bronx Park Assets Alan and Patti Brownstein Brian and Annie Buinewicz Scott and Sandy Budinsky Andrew and Kathy Chen Michael Christenson John Donahue Enantigen Therapeutics Alan and Irma Freedman James Horan Joanne Jensen Emmet Keeffe Dale Kindregan Anthony Klockenbrink Richard Chung-Wen Liu Arline Loh Medical Diagnostic Laboratories James Mongold Janice Morris Deborah Nelson Paul Nelson Prodesco Yusheng Qu Virginia Shames Beth Snyder David Tolle Elizabeth Walsh Lindsey Wayne and Eva Hogg John Wu and Kimberly Harper Discovery Circle — $250 - $499 Susannah Amiteye Baldwin Publishing Bee Bergvall and Company Richard Bendis Joanne Blasenheim Joyce Block Boa Construction Mary Boatner Bucks County Community College P. (Peter) Chiang Paul and Chari Cohen Steve and Janet Cohen Bertha Conyers CP Commercial Printing Andy Cuconati Joshua and Miriam Feldstein Fox Chase Cancer Center Jamie Fox Robert Frey Curt and Roseanne Friehs Gregory Gore Thomas Grim Henry “Dutch” and Kim Gronendahl Caitlyn Hoang Peter and Judith Hoekstra Wilson Hong Joyce Huber Patrick Hylton Scott Jacobs John Jennings Donald and Kimberly Jungkind Patrick and Cynthia Kelly Martin Kimmel Izabel Lam Peter Lamberts Raymond Lee Robert Leventhal Madison Associates Marketri Patrick Marra Mercer Communications Jean Miller Tulin Morcol Catherine Ng Timothy Peissig Thomas Quirk, Jr. David Rolf The Sawtooth Group Richard Sokorai Susan Stellini Eric Stollnitz Ying-Hsiu Su Sun Microsystems Foundation James Talamonti Dan and Cindy Taylor David Thompson Sarah Williams George and Cathleen Woods Mary Yee ADVOCACY ON THE HILL (Minnesota) 5 Million Americans Silent No More! HBF helped to organize the first World Hepatitis Day Rally on May 19th in Washington, DC with the National Viral Hepatitis Roundtable which sponsored the event. More than 50 HBF researchers, outreach staff and board members traveled to the Capitol to advocate for increased federal attention and funding for chronic hepatitis. With more than 5 million Americans living with hepatitis B and C, we cannot be silent anymore. Congressman Mike Honda sounds the alarm at the World Hepatitis Day rally. PA Congressman Patrick Murphy stands with the HBF at the historic World Hepatitis Day rally in Washington, DC. Landmark IOM Report on Hepatitis and Liver Cancer HBF Joins Historic New Asia Pacific Coalition HBF is proud to have been a key participant in the Institute of Medicine (IOM) study that looked at the U.S. response to chronic viral hepatitis. The landmark IOM report on Hepatitis and Liver Cancer concluded that, “The current approach to the prevention and control of chronic hepatitis B and hepatitis C is not working” and that “inadequate resources are being allocated” to address the needs of 5 million affected Americans. The IOM committee met over an 18-month period and included two HBF scientific advisers — Drs. Harvey Alter and Brian McMahon — and HBF director of Public Health Research Dr. Alison Evans. HBF co-founders Timothy and Joan Block (standing, center) were invited to present U.S. advocacy successes at a workshop in Beijing to discuss better policy coordination for hepatitis B in the Asia Pacific. The workshop included leading clinicians in the region and other international groups. Discussions revolved around the need to identify public policy issues that impede optimized screening and linkage to care, and to develop practical strategies to reduce the burden of hepatitis B. At the conclusion of the workshop the decision was made to establish a new independent, multi-disciplinary group — Coalition for Eradication of Viral Hepatitis in Asia Pacific (CEVHAP) — and HBF is proud to be a charter member. Hepatitis B Foundation 2010 Annual Report “Our daughter was adopted from China and most likely infected at birth. Your work to increase awareness of HBV will surely lead to more extensive research, and —I pray—an eventual cure. Thank you.” 11 Outreach Circle — $100 - $249 Matthew Adlai-gail Barbara Allar Debra Andrews Michael and Iris Artaki Artisans Gallery Richard Bader Eileen Beck Susan Bellaire Patricia Benham Brant Biehn Earl Bierman Bob Bowman Matt Buchwitz Jose Mari Casas Garrett Chang Gang Chen Francis and Linda Chisari Marc and Ann Clearfield Joe and Molli Conti Margaret Copeland Alioune Coulibaly David Crane Suzanne Crilley James and Carol Curry Loren Danzis David and Doris Dowdy Tom Drakeford Patricia Dunn Gregory Farkas Eric and Elizabeth Friedman Lawrence Friedman Roger and Nancy Gallic GE Foundation Genentech Givingstation Robert Gish Give With Liberty Campaign GoodSearch Mary Goudreault William Green David and Cynthia Gruber Ziying Han Richard and Hie-Won Hann Dorothy Harris Carol Hart Anne Heacock Harry and Dorothy Hellerman Harry Hicks David and Debra Hines Henry Ho Dorothy Hopkins David Huang Paul and Laura Hunter Jun Iwata Sherry Jean Bonnie Jung Margaret Keenan Alan Keim Robert Kelley Dan Kilcup KT Foundation Albert Ku Shailesh Kulkarsh Michael and Jan Landis John and Barbara Leavy Rachel Lefkowitz Kathy Licht Jun Luo Scott and Daryl MacKeverican Shing-Wen Mao Gerard Marini Donna Mattox Patti McAloon Jim McGowan Brian McMahon Ed Meyers Patti Monaco Joanne Moroney Richard Moyer John Nardini Clyde and Mable Ng John and Joann Nonini Lauren Nonini Eleanor Orth Edward Peritz Janet Perper Pina’s Pizza of Chalfont Prudential Foundation Matching Gifts Joohyun Pyune Xiangdong (David) Ren Carol Rico Richard and Priscilla Rosenberger Kenneth and Maria Rothstein Bill Royal Russell Biotech Tom Russell Kathleen Russo James Ryan James Samuels Ronald and Joyce Sanderson Marlene Schaps Lester Sdorow Richard Senker John and Susan Shelly James and Erica Shrimp Nancy Marie Sidun CALENDAR YEAR 2009 DONATIONS (continued) Harriet Stenzel Herbert and Joan Stevens Frederick Stiff Linhui Sui Judy Tam Joly Tang John Taylor Titan Mobile Shredding Thomas and Jessica Truong Eva Tsai Walter Tsou C. Theodore Tucker Uptowne Deli & Pizzeria Sharon Victor Kathleen Watson Michael Wehner Wells Fargo Community Support Campaign Dietmar and Mary Lou Weselin Deborah Wexler Thomas Wight Nicholas and Monica Winter Stephen Wong Ben Woods Alan Chung-I Yu Greg Zappin Edward Zekas Mingyu Zhu Awareness Circle — Up to $99 Ishola Adeyemo Steve Alexander Danna Arnold Earlene Austin Bank of America Matching Gifts Laurie Beckert Jackie Benson Priscilla Bizer Geraldine Block Paul Burton Joyce Cain Su Cartmell Everett and Diana Chambers Daniel Champagne Ka-Ming Chan Yeuk “Atom” Chan Joseph Chan Chun Chang Henry Chuang Robert Cohen Anthony Colella Joan Copp Lorie Corley Kathy Crissey Brian Dang Raymond D’Auria R. Kimber and Christine David Angelo DeMeo Massimo and Mariachristina Di Blasio Se Jong Ding Paul Dominguez William and Patricia Donaldson John and Sandra Draus Diane Ellis-Marseglia Employment & Community Options Linda Essary John Estok Rich and Terri Ferraro Kenneth and Anne Fields Edward Fischer Frank and Glenna Follmer Brian Free Thomas Freeman Susan Gabai Kathleen Garcia Inge Green Cindy Gutowski Richard and Renee Haliburton Eric and Elizabeth Cohen Hamblet Glenn Hammond Hunt Hawkins Marc Helman Hollenbach Family Max Holt Alfred and Evelyn How Becky Hubbell Kevin Hull Steven and Jo Ann Hurley Sam Hurwitz Suzanne Jeakle JP Morgan Chase Employee Giving Barry and Yoli Kahn Nina Katz Kathleen Kerrigan Barbara Kilgallon Fawn King Sherrin Krueger Denise Kunkel Robert and Cheryl Lagay Linda Landy Bruce and Eva Marie Lauer James and Hope Leahey Christopher and June Leavy King Liang Michael and Donna Line Erica Litschi Frank Liu Lan Liu Mei Mei Ma Thomas and Lori Macisaac Jeffrey Markowitz Tulaga Masaniai Candice Vargas McAuliffe Don McGee Patrick and Maureen Cronin-McLaughlin Reggie and Neema Chong Michaud Robert Mickle, Jr. Caroline Minnerick Edith Mock Carlo Momo Leslie Moore Morgan Stanley Louis Muzekari Ulviyya Nasibova Network for Good Thuan Nguyen Peter Nguyen Mark Obermann John Oldani Shannon O’Neill Tsung Hsi Oulee Mike and Meg Ovitt St. Thomas Parish Pfizer United Way Campaign Rose Poponi Kristine Powell David Provenzano Michelle Pugh John and Sandra Quirinale Bob and Jackie Radenbaugh Wen X. Zeng Raiti Florence Render Charles and Lorie Roth Matthew Schneider Larry Schneiderman Dennis Schuster Yeh-Heng Sheng Robert and Mary Sheppard Robert Shore Sara Shupe I. Earl and Janet Nancy Simon Priscilla Smith Terry Spencer Lauren Sproull Denise Stern Jeanne Stern Christian Stranutu Terry Strickland, II Janet Tangney Andy Tien Nancy Tolle Harry Tse and Zinna Lee Hin Wing Tse Heng Fu Tseng United Way California Capital Region Employees Campaign Ron Uroda Deb Watkins Carrie Welch Vanessa Wenzell Lt. Roy Williams Catherine Wolfe Robert Woo Lixun Zhang Zhong Zheng Amy Zipp CORPORATE AND FOUNDATION GRANTS AAPCHO Bayer Bristol-Myers Squibb Gilead Sciences GlaxoSmithKline Idenix Johnson & Johnson Merck & Co. Merck West Point Charitable Contributions Committee Novartis Onyx Vertex Pharmaceuticals FEDERAL AND STATE GRANTS National Institutes of Health Pennsylvania Department of Health We apologize for any errors or omissions in the donor list despite our best efforts to be as accurate as possible. Please contact editor@hepb.org or call 215-489-4900 so that we can print corrections in our next newsletter. Thank you. Hepatitis B Foundation 2010 Annual Report CALENDAR YEAR 2009 DONATIONS (continued) RESEARCH, Education and Advocacy IS THE KEY Hepatitis B is an enormous global health problem. • 2 billion people worldwide have been infected by hepatitis B. (1 out of every 3) • 1 million people in the world die from hepatitis B each year. Hepatitis B causes 80% of primary liver cancer worldwide. • Liver cancer is the 3rd leading cause of death in the world. • In the U.S., liver cancer rates are increasing as most other types of cancer are decreasing. • The hepatitis B vaccine is the 1st anti-cancer vaccine — by preventing a hepatitis B infection. There is no known cure for more than 400 million people worldwide living with hepatitis B. • Hepatitis B is preventable and treatable — now let’s make it curable! Learn more about hepatitis B and the important work of the Hepatitis B Foundation by visiting www.hepb.org.