BIOL 250 Genetics - Department of Biology

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BIOL 250

Date

25 Aug-Tue

16 Sep-Wed

23 Sep-Wed

Genetics, Fall 2015, 3.0 credits

Lecture topic

Introduction

DNA: The genetic material

DNA replication

Gene function

Gene expression: Transcription

Gene expression: Translation

DNA mutation & DNA repair

Review Session for Exam #1

Exam #1 - Chapters 1 to 7a

Transposable elements

Recombinant DNA technology

Chapter

1

2

3

4

5

6

7a

7b

8

9a

21 Oct-Wed

28 Oct-Wed

PCR, DNA sequencing, and single nucleotide polymorphisms (SNPs)

DNA fingerprinting with microsatellites, restriction fragment length polymorphisms (RFLPs), &

Southern/Northern blots

Genome-wide association studies & chromosome walking

Shotgun genome sequencing & functional genomics

Mendelian genetics

Chromosomal basis of inheritance

Extensions of Mendelian genetic principles

Non-Mendelian inheritance

Review Session for Exam #2

Exam #2 - Chapters 7b to 14

Genetic mapping in eukaryotes

Genetics of bacteria and bacteriophages

Variation in chromosome structure and number

Regulation of gene expression in bacteria and bacteriophages

Regulation of gene expression in eukaryotes

Genetic analysis of development

Genetics of cancer

Population genetics 1

Population genetics 2

Quantitative genetics

Molecular Evolution

Review Session for Exam #3

Exam #3 (chapters 15–23 + inclusive) 5:00-7:30 PM

9b

10a

10b

11

12

13a

13b

14

15

16

17

18

19

20

21a

21b

22

23

09 Dec-Wed

15 Dec-Tue

Location and time:

Tuesday & Thursday 2:00 – 3:15 PM, Cox Science 126, Wednesday 3:30 – 4:45 PM, TBA (3 rd

class time available for review sessions & exams)

Textbook:

Peter J. Russel. 2010. iGenetics: A Molecular Approach, 3 rd

California. ISBN 0-321-56976-8/978-0-321-56976-9

edition. Pearson Education, San Francisco,

Important dates:

09 September - Last day to drop a course without a W

26 October - Last day to drop a course (W grade given for course)

08-11 October - Fall recess

21-29 November - Thanksgiving recess

09 December – Last day of class (review session)

15 December – Final Exam 5:00 to 7:30 PM

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Web content:

Course web site (UAF): http://www.bio.miami.edu/mccracken/genetics/ iGenetics web site: http://www.aw-bc.com/geneticsplace/

Web site includes: iActivities, animations, practice quizzes, glossary, and solutions to end-of-chapter problem sets.

Grading:

Exam 1 30%

Exam 2 35%

Exam 3 35%

Optional Paper 5% (Bonus)

*One 5-page (double-spaced) paper for 5% bonus. This may be turned in anytime after fall recess, but no later than 1 December. Topics should focus on a theme of modern 21st century genetics that is of personal or professional interest. Examples might include an overview of recent technological developments in molecular genetic technology (e.g., next-generation methods of whole genome DNA sequencing, recombinant DNA, gene discovery & isolation etc.); genetics of a particular disease or public health problem; or conservation and evolutionary genetics. These are just some possible topics.

Anything is possible, but please confirm your topic with the instructor or TA prior to writing.

*Study questions will be provided online so that you have the opportunity to work through difficult concepts prior to your exams. These will not be graded, but your instructors will discuss these questions and answers during scheduled review sessions.

*Review sessions and exams will take place during the Wed slot at 3:30 – 4:45 PM (Location TBA).

*3% bonus added to final grade for 100% lecture attendance (attendance will be sampled randomly).

*Exams in this course are purposely designed to be challenging, and it is not uncommon for raw scores to be low (e.g., means of 50-65%)—exam and final grades will be curved appropriately based on the overall means for each exam.

Exam make-up policy:

Make-up exams are not generally given. If circumstances are such that you are unable to take the exam, please contact me by e-mail ([email protected]) in advance of the exam. Otherwise, no make-up exam will be given and your grade will be zero for that exam.

Incomplete policy:

Incomplete grades are discouraged and will only be authorized under exceptional circumstances. Your performance and participation in the course will factor into this decision.

Student code of conduct:

Students are subject to the UM Student Honor Code. Plagiarism, cheating, and other forms of academic dishonesty will not be tolerated. All cases in which students participate or appear to participate in these types of activities will be referred to the UM Honor Council, Dean of Students.

Finding of a violation by the UM Honor Council will result in failure of the course (not just the assignment).

Other policies:

Needs of students with disabilities will be accommodated following university policies. Please talk to the instructor if you require assistance. The Office of Disability Services in the Academic Resource

Center, N201, Whitten University Center provides disability services. Student athletes and members of the U.S. military should coordinate their absences with the instructor in advance.

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Contact information:

Kevin G. McCracken

Department of Biology

#188 Cox Science Center (1

University of Miami st

Floor, North Side)

Coral Gables, FL 33146 office (305) 284-3753 email: [email protected]

Office hours:

Tuesday & Thursday before and after class or by appointment.

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