AbstractID: 9813 Title: Flat Panel Detector-based Cone Beam Volume CT Imaging A great deal effort has been devoted to the development of the cone beam volume computed tomography imaging technique in the past. It is proposed to address the limitations of current helical CT in medical imaging with the cone beam volume CT (CBVCT) imaging technique which uses a cone beam geometry volume scan and a two dimensional detector. True CBVCT is the next evolutionary step of CT development. Actually, a few CBVCT prototypes have been introduced in the past decade, and the development of the flat panel detector (FPD) is making CBVCT imaging more competitive. The author will discuss the principals of cone beam volume CT, its potential clinical advantages over conventional CT and spiral CT (including multi-slice CT), key technical problems to be solved, and the development of cone beam reconstruction algorithms. The author has been working on four applications of the CBVCT imaging technique for over ten years: 1. cone beam volume CT angiography, 2. cone beam volume CT for lung cancer detection, 3. cone beam volume CT breast imaging and 4. micro-cone beam volume CT for small animal imaging. The results of phantom, animal or specimen studies for each application of CBVCT will be presented and the future directions of these projects will be outlined. KEYWORDS: cone beam volume CT, cone beam reconstruction, digital subtraction angiography, digital mammography, mammography, flat panel detector, breast imaging.