Aventis Pasteur
The Value of Vaccines
Vaccines mean freedom from disease for
millions of people worldwide
■
Immunization is a critical weapon in the battle to control and
eliminate infectious diseases
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High immunization rates often push disease rates to less than
1% or near eradication1
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Today 12 diseases are largely prevented by immunization,
including polio, pertussis, and influenza1
■
Immunization saves the lives of approximately 3 million
children around the world annually 2
Vaccines protect society and improve
personal health
■
Immunization does more than just protect individuals, it
prevents the spread of disease among entire populations
■
Large-scale vaccination has helped eliminate diphtheria,
tetanus, and polio from most of the developed world and
has eradicated smallpox 3
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Historic rates for diphtheria in the U.S. dropped from over
206,000 cases and 15,520 deaths in 1921 to only 1 case in 2000 4
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80 million doses of influenza vaccine were distributed in the U.S.
in 2001, saving lives and reducing the burden of disease on society 5
Vaccines reduce human and economic costs
■
Since the introduction of the first Hib vaccine in 1987, cases
among children under five have fallen from 20,000 a year to
an average of 68 cases annually.6
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For every dollar used to buy DTaP vaccine, approximately $8.50
in direct medical costs and approximately $15.50 in indirect
social costs in the U.S. is saved.7
References: 1. Centers for Disease Control and Prevention (CDC). Ten great public health achievements-United States, 1900-1999. MMWR Morb Mortal Wkly Rep..1999;48(12);241-264. 2. Kane M,
Lasher H. The case for childhood immunization [Occasional Paper #5]. Children’s Vaccine Program at PATH. 2002. 3. Centers for Disease Control and Prevention (CDC). Achievements in public health.
MMWR Morb Mortal Wkly Rep.1999;48(29);621-649. 4. Centers for Disease Control and Prevention (CDC). Epidemiology and Prevention of Vaccine Preventable Diseases, 7th Ed. Atlanta, GA: CDC;.
2002:44. 5. Findings. The Washington Post. October 17, 2001. [Final Edition]. 6. Centers for Disease Control and Prevention (CDC). Epidemiology and Prevention of Vaccine Preventable Diseases, 7th Ed.
Atlanta, GA: CDC;. 2002:86. 7. National Immunization Program. AAP/ASTHO Congressional Briefing On Immunization. Available at: http://www.cdc.gov/nip/prog/aap-astho.htm. Accessed July 19, 2002
8. Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA. 1999;281(1):61-66.
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© 2002 Aventis Pasteur Inc.
9/02
Printed in USA
Vaccines: A Century
of Progress in Protection
Immunization results in dramatic
reductions in mortality
CRUDE DEATH RATES FROM INFECTIOUS DISEASE IN THE U.S.3,8
Rate per 100,000
1000
Influenza
pandemic 1918-19
(797 deaths
per 100,000)
800
Last Human
transmission of Plague
600
Penicillin
Salk Vaccine
400
Water
chlorination
introduced
200
Vaccine
Assistance Act
AIDS (63 deaths
per 100,000)
1920
1900
1940
1960
1980
2000
Adapted from MMWR 1999;48(29):621-629 and JAMA 1999;281(1):61-66.
Vaccines demonstrate significant economic savings
COST BENEFIT ANALYSIS OF COMMONLY USED VACCINES IN THE U.S.7
VACCINE
SAVINGS PER DOLLAR SPENT
$24
DTaP
Hepatitis B
MMR
H. influenzae
type b
$13.5
$2.20
$14.50
Perinatal
$3.10
Infant
$2.20
Adolescent
Direct medical savings
Indirect savings
$5.40
$5.45
Varicella
All IPV
0
$5
$
$10
Total Savings
$15
$20
$25
Adapted from Centers for Disease Control & Prevention