:HVWHUQ$XVWUDOLDQ&HUWL¿FDWHRI(GXFDWLRQ ([DPLQDWLRQ 4XHVWLRQ$QVZHU%RRNOHW HUMAN BIOLOGICAL SCIENCE 3OHDVHSODFH\RXUVWXGHQWLGHQWL¿FDWLRQODEHOLQWKLVER[ Stage 2 Student Number: ,Q¿JXUHV ,QZRUGV Time allowed for this paper Reading time before commencing work: Working time for paper: ten minutes three hours Materials required/recommended for this paper To be provided by the supervisor This Question/Answer Booklet Multiple-choice Answer Sheet Number of additional answer booklets used (if applicable): To be provided by the candidate Standard items: pens (blue/black preferred), pencils (including coloured), sharpener, FRUUHFWLRQÀXLGWDSHHUDVHUUXOHUKLJKOLJKWHUV Special items: non-programmable calculators approved for use in the WACE examinations Important note to candidates No other items may be taken into the examination room. It is your responsibility to ensure that you do not have any unauthorised notes or other items of a non-personal nature in the examination room. If you have any unauthorised material with you, hand it to the supervisor before reading any further. 2014/7051 Web version of 2013/42749 Copyright © School Curriculum and Standards Authority 2013 Ref: 13-060 HUMAN BIOLOGICAL SCIENCE 2 STAGE 2 Structure of this paper Number of questions available Number of questions to be answered Suggested working time (minutes) Marks available Percentage of exam Section One: Multiple-choice 30 30 40 30 30 Section Two: Short answer 9 9 90 100 50 Section Three: Extended answer 4 2 50 40 20 Total 100 Section Instructions to candidates 1. The rules for the conduct of Western Australian external examinations are detailed in the Year 12 Information Handbook 2013. Sitting this examination implies that you agree to abide by these rules. 2. Answer the questions according to the following instructions. Section One: Answer all questions on the separate Multiple-choice Answer Sheet provided. For each question, shade the box to indicate your answer. Use only a blue or black pen to shade the boxes. If you make a mistake, place a cross through that square, WKHQVKDGH\RXUQHZDQVZHU'RQRWHUDVHRUXVHFRUUHFWLRQÀXLGWDSH0DUNVZLOOQRW be deducted for incorrect answers. No marks will be given if more than one answer is completed for any question. Sections Two and Three: Write your answers in this Question/Answer Booklet. <RXPXVWEHFDUHIXOWRFRQ¿QH\RXUUHVSRQVHVWRWKHVSHFL¿FTXHVWLRQVDVNHGDQGWR IROORZDQ\LQVWUXFWLRQVWKDWDUHVSHFL¿FWRDSDUWLFXODUTXHVWLRQ 4. Spare pages are included at the end of this booklet. They can be used for planning your responses and/or as additional space if required to continue an answer. Ɣ Planning: If you use the spare pages for planning, indicate this clearly at the top of the page. Ɣ Continuing an answer: If you need to use the space to continue an answer, indicate in the original answer space where the answer is continued, i.e. give the page number. Fill in the number of the question that you are continuing to answer at the top of the page. See next page STAGE 2 3 HUMAN BIOLOGICAL SCIENCE Section One: Multiple-choice 30% (30 Marks) This section has 30 questions. Answer all questions on the separate Multiple-choice Answer Sheet provided. For each question, shade the box to indicate your answer. Use only a blue or black pen to shade the boxes. If you make a mistake, place a cross through that square, then VKDGH\RXUQHZDQVZHU'RQRWHUDVHRUXVHFRUUHFWLRQÀXLGWDSH0DUNVZLOOQRWEHGHGXFWHGIRU incorrect answers. No marks will be given if more than one answer is completed for any question. Suggested working time: 40 minutes. 1. The name for chemical reactions that require energy to form larger molecules from smaller molecules is (a) (b) (c) (d) anabolism. catabolism. respiration. digestion. Questions 2 and 3 refer to the diagram below, which shows part of a DNA molecule. P P A P P P P B 2. The part of the DNA molecule in the shaded box labelled ‘A’ is a (a) (b) (c) (d) 3. S C S A P P deoxyribose sugar. nucleotide. ribose sugar. peptide. If one of the molecules found in the shaded box labelled ‘B’ is adenine, its partner molecule must be (a) (b) (c) (d) guanine. cytosine. thymine. uracil. See next page HUMAN BIOLOGICAL SCIENCE 4. breast milk is cheaper than purchasing milk formula breast milk is always sterile and at the correct temperature infants receive antibodies from their mothers’ milk mothers know exactly how much their infants have consumed Proximodistal pattern of motor development in babies means that movements of D E F G 6. STAGE 2 Which of the following is not an advantage of breast feeding an infant? (a) (b) (c) (d) 5. 4 SDUWVRIWKHOLPEVFORVHVWWRWKHERG\DUHFRQWUROOHG¿UVWDQG¿QHPRWRUFRQWURORI ¿QJHUVRFFXUVODVW ODUJHUPXVFOHJURXSVDUHFRQWUROOHG¿UVWDQGFRQWURORIWKHVPDOOHUPXVFOHJURXSV occurs last. SDUWVRIOLPEVIXUWKHUDZD\IURPWKHERG\DUHFRQWUROOHG¿UVWDQGJURVVPRWRU FRQWURORI¿QJHUVRFFXUVODVW VPDOOHUPXVFOHJURXSVDUHFRQWUROOHG¿UVWDQGFRQWURORIWKHODUJHUPXVFOHJURXSV last. Edwards syndrome is a condition caused by the chromosomal mutation described as trisomy-18. Which of the diagrams below correctly shows the karyotype of a male with Edwards syndrome? (a) (b) (c) (d) See next page STAGE 2 7. HUMAN BIOLOGICAL SCIENCE 5 In humans, colour blindness is an X-linked recessive condition. If a normal man has a child with a woman who is a carrier for the condition of colour blindness, what is the chance that one of their children will be born colour blind? (a) (b) (c) (d) 0.25 0.50 0.75 1.0 Questions 8 and 9 refer to the diagram below. :KLFKRIWKHIROORZLQJFRUUHFWO\LGHQWL¿HVWKHVWUXFWXUHVODEHOOHGµ$¶µ%¶DQGµ&¶" (a) (b) (c) (d) 9. A: nucleus A: ribosomes A: Golgi body A: mitochondria B: ribosomes B: mitochondria B: nucleus B: Golgi body C: mitochondria C: nucleus C: ribosomes C: ribosomes Which of the following best describes the function for the organelle labelled ‘D’? (a) (b) (c) (d) moves substances across the cell membrane transports materials around the cell controls all cell activities packages materials for export from the cell See next page HUMAN BIOLOGICAL SCIENCE 10. 6 STAGE 2 Which of the following uses the largest amount of the energy produced by the body? (a) (b) (c) (d) production of heat cell growth and division movement of the cell and cell organelles active transport Questions 11 and 12 refer to the diagram below. 11. Part F is the (a) (b) (c) (d) vas deferens. bladder. prostate gland. urethra. 7KHVWUXFWXUHVVKRZQLQWKHGLDJUDPWKDWDGGÀXLGWRWKHVSHUPWRIRUPVHPHQDUH (a) (b) (c) (d) A and C. A and B. B and C. A and F. See next page STAGE 2 HUMAN BIOLOGICAL SCIENCE ,QZKLFKRIWKHIROORZLQJWLVVXHVZRXOG\RXH[SHFWWR¿QGWKHmost mitochondria present? (a) (b) (c) (d) 14. 7 skin cartilage muscle tissue bone tissue In which type of cell would a mutation not be passed on to future generations? (a) (b) (c) (d) somatic cells germ line cells ovum cells sperm cells Questions 15 and 16 refer to the diagram below. Blood cells A 15. D E A. B. C. D. The type of blood cell shown in the diagram as ‘E’ plays an important role in the LQÀDPPDWRU\UHVSRQVH7KLVUROHLVWR D (b) (c) (d) 17. C The type of blood cells that carry oxygen around the body is (a) (b) (c) (d) 16. B LQFUHDVHEORRGÀRZ prevent blood clotting. stimulate pain receptors. engulf micro-organisms. The formation of ATP during aerobic respiration is best represented by D E F G JOXFRVHR[\JHQĺFDUERQGLR[LGHZDWHU$73 JOXFRVHR[\JHQĺFDUERQGLR[LGHZDWHU$73 JOXFRVHĺFDUERQGLR[LGHZDWHU$73ODFWLFDFLG JOXFRVHR[\JHQĺFDUERQGLR[LGHZDWHU$73 See next page HUMAN BIOLOGICAL SCIENCE 18. STAGE 2 The basic building blocks of lipids include (a) (b) (c) (d) 19. 8 amino acids only. fatty acids and amino acids. fatty acids and glycerol. saccharides and glycerol. The foramen ovale is the hole in the foetal heart that allows blood to move through it more quickly. Which of the following shows the correct location of the foramen ovale? (a) (b) For copyright reasons this image cannot be reproduced in the online version of this document. (c) 20. Which of the following will be true for a man suffering Huntington’s disease? (a) (b) (c) (d) both of his parents must have suffered from Huntington’s disease he will pass Huntington’s disease to each of his children it is possible that neither of his parents suffered from Huntington’s disease at least one of his parents suffered from Huntington’s disease %HVLGHVVKRFNDEVRUSWLRQRQHRIWKHUROHVRIWKHDPQLRWLFÀXLGGXULQJSUHJQDQF\LVWR (a) (b) (c) (d) 22. (d) provide nutrients and oxygen to the foetus. contribute to the development of the umbilical cord. form part of the placenta. help to maintain a constant temperature. Antivirals are medications that (a) (b) (c) (d) inhibit the development of viruses. destroy all pathogens. inhibit fungal and bacterial growth. kill viruses. See next page STAGE 2 9 HUMAN BIOLOGICAL SCIENCE Questions 23, 24 and 25 refer to the diagram below showing embryonic and foetal development. For copyright reasons this image cannot be reproduced in the online version of this document. 23. Which of the following is the correct timing of Stage IV as shown in the diagram? (a) (b) (c) (d) 24. Which of the following major developments occurs around the time of Stage III? (a) (b) (c) (d) 25. accumulation of fat beneath the skin and growth slowed respiratory and digestive systems start to function limbs are well developed and bone marrow has been formed all organs are present and leg buds appear Shortly after which stage of development would a mother normally start to feel small movements from the foetus? (a) (b) (c) (d) 26. 16 weeks 18 weeks 24 weeks 28 weeks I II III IV The major achievement of the Human Genome Project has been the (a) (b) (c) (d) collection of DNA samples from every major group of people. elimination of genetic diseases. development of drugs that are matched to an individual’s DNA. establishment of the complete sequence of bases in human DNA. See next page HUMAN BIOLOGICAL SCIENCE 10 STAGE 2 Questions 27, 28 and 29 refer to the diagram below. E For copyright reasons this image cannot be reproduced in the online version of this document. 27. Which process best represents diffusion? (a) (b) (c) (d) 28. Structure E is a (a) (b) (c) (d) 29. channel protein. carrier protein. phospholipid molecule. cholesterol molecule. Which of the process/es represent the movement of a substance from an area of high concentration to an area of low concentration? (a) (b) (c) (d) 30. A B C D A A, B and C B and D D In humans, the urinary tract is designed to resist infection. It is able to achieve this because (a) (b) F (d) the thick lining is an effective physical barrier to infection. the acid environment destroys many pathogens. LWLVOLQHGZLWKVSHFLDOJODQGVWKDWVHFUHWHDQDQWLVHSWLFÀXLG the thick mucus lining traps invading organisms. End of Section One See next page STAGE 2 11 HUMAN BIOLOGICAL SCIENCE This page has been left blank intentionally See next page HUMAN BIOLOGICAL SCIENCE 12 Section Two: Short answer STAGE 2 50% (100 Marks) This section has nine (9) questions. Answer all questions. Write your answers in the spaces provided. Spare pages are included at the end of this booklet. They can be used for planning your responses and/or as additional space if required to continue an answer. Ɣ Planning: If you use the spare page for planning, indicate this clearly at the top of the page. Ɣ Continuing an answer: If you need to use the space to continue an answer, indicate in the original answer space where the answer is continued, i.e. give the page number. Fill in the number of the question that you are continuing to answer at the top of the page. Suggested working time: 90 minutes. Question 31 (8 marks) The following question refers to the diagram of the female reproductive system below. For copyright reasons this image cannot be reproduced in the online version of this document. (a) Identify the structure labelled ‘A’. (1 mark) (b) State the function of the structure labelled ‘B’. (1 mark) See next page STAGE 2 (c) G 13 HUMAN BIOLOGICAL SCIENCE At which location on the diagram do the following events normally occur (i) fertilisation of the ovum? (1 mark) (ii) implantation of the zygote? (1 mark) 7KHELUWKLQJSURFHVVLQYROYHVWKUHHVWDJHVRIODERXU7KH¿UVWVWDJHRIODERXULVFDOOHGWKH stage of dilation. L ,GHQWLI\WKHVWUXFWXUHVKRZQRQWKHGLDJUDPWKDWGLODWHVGXULQJWKH¿UVWVWDJHRI labour. (1 mark) LL ([SODLQKRZWKHGLODWLRQRIWKHVWUXFWXUHLGHQWL¿HGLQSDUWGLLVHVVHQWLDOIRUWKH birthing process. (1 mark) (iii) Complete the table below, describing the main event that occurs during the second and third stages of labour. (2 marks) Stage Main event that occurs during the stage 2 3 See next page HUMAN BIOLOGICAL SCIENCE 14 STAGE 2 Question 32 (10 marks) Parts (a) and (b) of the following question refer to the diagram below. For copyright reasons this image cannot be reproduced in the online version of this document. The diagram is a representation of the model called the ‘lock and key’, which is used to help explain the way enzymes work. (a) Using the lock and key model, name the following molecules. (3 marks) B: A and C: A B C: (b) On the diagram above, draw a circle around the active site. (1 mark) Parts (c) and (d) of the question refer to the information and diagram below. A student used an enzyme to combine two types of sugars. Shown below is a graph of the rate of reaction as temperature increases. S C S A 40 See next page STAGE 2 15 HUMAN BIOLOGICAL SCIENCE Complete the following questions, referring to the line on the graph. (c) Describe the rate of reaction as temperature increases. (3 marks) Before 40 ºC: At 40 ºC: After 40 ºC: (d) Complete the following sentences relating to the reaction shown in the graph. (3 marks) The activation energy of a reaction is the energy required to a chemical reaction. The rate of the reaction up until 40 ºC has been altered by the presence of an enzyme. The enzyme has worked to the activation energy of the reaction. After 40 ºC the reaction rate has changed because the heat has caused the to change shape. See next page HUMAN BIOLOGICAL SCIENCE 16 Question 33 STAGE 2 (9 marks) Parts (a), (b) and (c) of the question refer to the diagram of the nephron shown below. (a) Identify the structures labelled ‘B’ and ‘C.’ (2 marks) B: C: (b) State the function of the structures labelled ‘A’ and ‘D’. A: D: See next page (2 marks) STAGE 2 (c) 17 HUMAN BIOLOGICAL SCIENCE What function do the structures labelled ‘E’ and ‘F’ perform that affects the composition of urine? (4 marks) E: F: (d) Name the organ of the body that produces urea. See next page (1 mark) HUMAN BIOLOGICAL SCIENCE 18 Question 34 STAGE 2 (13 marks) Parts (a), (b), (c) and (d) of the question refers to the pedigree diagram displaying the inheritance of freckles in a particular family shown below. (a) Freckles are a trait inherited on one pair of autosomal chromosomes. (i) State whether freckles is a dominant or recessive trait. (1 mark) (ii) Use the information in the pedigree to provide a reason for your answer in part a (i) (2 marks) (b) The pedigree diagram does not have labels on it indicating the generations. Using the correct convention, label the three generations on the diagram. (1 mark) (c) State the genotype of Individual 8. See next page (1 mark) STAGE 2 HUMAN BIOLOGICAL SCIENCE 19 (d) Individual 9 on the pedigree is planning to marry a female who has no freckles. What is the probability that any future children will have freckles? Show all workings in your answer, including the genotypes and phenotypes of all individuals involved and a punnet square diagram. (5 marks) (e) Complete the table below by describing the type of relationship each pedigree symbol indicates. (3 marks) Pedigree symbol Relationship indicated See next page HUMAN BIOLOGICAL SCIENCE 20 STAGE 2 Question 35 (12 marks) D 'H¿QHWKHWHUPµ67,¶ (b) Complete the table below by providing an example of an STI for each of the major types of organisms listed. Give one method used by medical professionals to treat the infection. (5 marks) Organism type PDUN Example Treatment Bacteria Virus Human LPPXQRGH¿FLHQF\YLUXV (HIV) Fungus Human Papilloma Virus (HPV) is an STI that has been linked to cervical cancer in females. Many girls in Western Australia are now immunised against this virus so that the chances of them later getting cervical cancer are greatly reduced. (c) It has been suggested that boys should also be given the HPV vaccine. Explain why this recommendation is made. (2 marks) (d) If left untreated, a number of STIs can lead to infertility in females. Outline how having an STI can lead to female infertility. (2 marks) See next page STAGE 2 (e) 21 HUMAN BIOLOGICAL SCIENCE Assisted reproductive techniques are strategies that medical professionals can use to help infertile women have children. Name two assisted reproductive techniques. (2 marks) One: Two: See next page HUMAN BIOLOGICAL SCIENCE 22 STAGE 2 Question 36 (16 marks) A researcher was conducting a study into the link between blood cholesterol levels and diet. As part of the study the researcher had two groups of subjects, aged between 25 and 45 years. Group A had 20 subjects who maintained their normal diet throughout the study. Group B had 22 subjects who adopted a healthy diet throughout the study. All subjects participated in the study for 4 months. Their blood cholesterol levels were checked every 2 weeks. Data collected from the study are provided below. Normal diet Healthy diet Time (weeks) Group A Average blood cholesterol (mmol/L) Group B Average blood cholesterol (mmol/L) 0 5.7 5.6 2 5.7 5.6 4 5.6 5.3 6 5.7 5.2 8 5.6 5.3 10 5.5 5.1 12 5.6 4.9 14 5.6 5.0 16 5.5 4.9 (a) Write a suitable hypothesis for the study. (b) In this study, identify the (c) (1 mark) (i) independent variable. (1 mark) (ii) dependent variable. (1 mark) State the name given to Group A and state the purpose of using this group. See next page (2 marks) STAGE 2 (d) 23 HUMAN BIOLOGICAL SCIENCE On the grid below, plot the data as a graph in the most appropriate style. (5 marks) If you wish to make a second attempt at the graph, the grid is repeated at the end of this Question/Answer Booklet. Indicate clearly on this page if you have used the second grid and cancel the working on the grid on this page. (e) The researcher stated that Group B adopted a healthy diet. This could mean several changes to what an individual does or does not consume during a day. (i) List three healthy diet choices. One: Two: Three: See next page (3 marks) HUMAN BIOLOGICAL SCIENCE 24 STAGE 2 Question 36 (continued) (ii) Explain why it was important for the researcher to test only one of the possible dietary changes and not many at the same time during the study. (1 mark) (iii) Suggest two other lifestyle choices, besides diet, that the researcher might also recommend for healthy living. (2 marks) One: Two: See next page STAGE 2 25 Question 37 HUMAN BIOLOGICAL SCIENCE (8 marks) (a) Name one of the three embryonic germ layers. (1 mark) E 'H¿QHWKHWHUPµSOXULSRWHQWFHOO¶ PDUN (c) There are two categories of stem cells: adult and embryonic. Name the locations from which these two types of cells are obtained. (2 marks) Embryonic stem cells: Adult stem cells: (d) Parkinson’s disease is caused by the degeneration and loss of cells from a central region in the brain. Describe the process by which cell replacement therapy could be used to treat this disease. (4 marks) See next page HUMAN BIOLOGICAL SCIENCE 26 STAGE 2 Question 38 (16 marks) S C S A Parts (a) and (b) of the question refer to the diagram of the digestive system below. (a) Identify the structures labelled ‘A’ and ‘B’. (2 marks) A: B: (b) Various functions of the digestive system are listed below. Match these functions with the labelled structures in the diagram above. Some of the functions described may match more than one labelled structure. Make sure you list all the structures that perform that function. (4 marks) Chemical digestion: Chemical digestion of protein: Absorption of nutrients and/or water: Bile production: See next page STAGE 2 27 HUMAN BIOLOGICAL SCIENCE Parts (c), (d) and (e) of the question refer to the diagram of the heart below. (c) Identify the structures labelled ‘W’ and ‘Z’. (2 marks) W: Z: (d) Describe the role of the structure labelled ‘V’ on the diagram. (e) Compare the vessels labelled ‘X’ and ‘Y’ by completing the table below. Vessel X Structure Function See next page (1 mark) Vessel Y (4 marks) HUMAN BIOLOGICAL SCIENCE 28 STAGE 2 Question 38 (continued) (f) Describe three events in the process of blood clotting. One: Two: Three: See next page (3 marks) STAGE 2 29 HUMAN BIOLOGICAL SCIENCE Question 39 (8 marks) D 'H¿QHWKHWHUPµWHUDWRJHQ¶ PDUN (b) Identify how most teratogens get from the mother to the embryo/foetus. (1 mark) (c) Timing of exposure to a teratogen is important. (i) At which time during gestation would you expect a teratogen to have the greatest effect on the development of the embryo/foetus? (1 mark) (ii) Apart from the timing, what critical factor determines the effect teratogens have on the development of an embryo/foetus? (1 mark) (d) Nicotine from cigarette smoke does not produce congenital malformations but it does affect the foetus. Name one effect it can have on a developing foetus. (1 mark) (e) A woman wishes to get pregnant. What recommendation would you give to her about the use of alcohol? Justify your answer by giving two reasons. (3 marks) End of Section Two See next page HUMAN BIOLOGICAL SCIENCE 30 Section Three: Extended answer STAGE 2 20% (40 Marks) This section contains four (4) questions. You must answer two (2) questions. Write your answers on the lined pages provided. Spare pages are included at the end of this booklet. They can be used for planning your answers and/or as additional space if required to continue an answer. Ɣ Planning: If you use the spare page for planning, indicate this clearly at the top of the page. Ɣ Continuing an answer: If you need to use the space to continue an answer, indicate in the original answer space where the answer is continued, i.e. give the page number. Fill in the number of the question that you are continuing to answer at the top of the page. Responses may include clearly-labelled diagrams with explanatory notes; lists of points ZLWKOLQNLQJVHQWHQFHVFOHDUO\ODEHOOHGWDEOHVDQGJUDSKVRUDQQRWDWHGÀRZGLDJUDPVZLWK introductory notes. Suggested working time: 50 minutes. Question 40 (20 marks) (a) Outline the pathway taken by air from outside the body through the human respiratory system to the point where gas exchange occurs. (7 marks) (b) The respiratory surface in the lungs is designed to maximise gas exchange. Identify and explain three features of the lung’s respiratory surface that allow for maximum gas exchange. (6 marks) (c) Breathing is an essential component of life. Explain the importance of breathing and describe the process of expiration. (7 marks) Question 41 (20 marks) (a) Describe the function of mitosis. List and describe the stages of mitosis. (13 marks) (b) Describe the function of meiosis. List and describe the events in meiosis that make it different from mitosis. (7 marks) See next page STAGE 2 31 HUMAN BIOLOGICAL SCIENCE Question 42 (a) (20 marks) Outline the changes to hormone levels and the events that occur during a normal menstrual and ovarian cycle of a non-pregnant female. Use the following headings to write your answer: Ɣ Ɣ Ɣ (b) Menstruation Days 1-4 Preovulation Days 5-12 Ovulation Days 13-15. (8 marks) There are many different types of contraceptive devices, which can be divided into three categories: Ɣ Ɣ Ɣ natural barrier chemical. For each category, select one example and provide its name, describe how it works and outline one advantage and one disadvantage associated with its use. (12 marks) Question 43 (20 marks) D 'H¿QHWKHWHUPPXWDJHQDQGOLVWfour possible mutagens. (b) Some genetic disorders can be more prevalent in certain populations. For the autosomal disorders listed below, identify a population that has a high incidence of the disorder, the type of inheritance it displays and the characteristics of the disorder. 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