We live
our mission
every day.
University Hospitals
has been recognized by the
American Hospital Association as
the top hospital in the
nation for its leadership
and innovation in quality
Scan the QR Code to the left or visit
UHhospitals.org/missionquality
to see how a focus on quality can
enhance outcomes and improve
a hospital’s overall performance.
To Heal.
To Teach.
To Discover.
Division of
Pulmonary,
Critical Care and
Sleep Medicine
A trusted resource for patients across the world, UH Case Medical
From the interim Chief
Center’s Division of Pulmonary, Critical Care and Sleep Medicine
brings together the country’s foremost experts in these disciplines.
Dear Colleague:
Innovative, integrated and individualized clinical care
is offered to patients with lung conditions and sleep disorders.
Delivering on our mission – To Heal. To Teach. To Discover. –
inspires our ongoing commitment to train the next generation
of physician-scientists and advance clinical research and new
treatment protocols.
Through a dedicated team of skilled specialists with access to
University Hospitals Case Medical Center is building upon a legacy of innovation that
began nearly 150 years ago and continues today through its Division of Pulmonary,
Critical Care and Sleep Medicine.
treatments and surgeries.
leading-edge technologies, facilities and research, the division
delivers superlative care for the full range of disorders, from
management of common conditions to the most advanced
This spirit of innovation and medical discovery is demonstrated today in a number of
programs and initiatives that are helping forge medicine’s future:
• Working closely with oncologists at University Hospitals Seidman Cancer Center,
using interventional bronchoscopy and clinical management skills to deliver
comprehensive respiratory care and rehabilitation.
Division of Pulmonary,
Critical Care and Sleep Medicine
• Oversight of the Beacon award-winning Medical Intensive Care Unit at
UH Case Medical Center, developing promising strategies to improve the
care of patients with acute respiratory distress syndrome (ARDS).
• Leadership in several clinical trials aimed at refining sleep apnea therapy
and treatments.
• The launch of The Harrington Project for Discovery & Development,
a $250 million investment in drug discovery and commercialization that
aligns a not-for-profit entity, Harrington Discovery Institute at University Hospitals
Case Medical Center, with a for-profit company, BioMotiv.
These and other UH Case Medical Center advances are poised to benefit
the lives of patients affected by lung conditions and sleep disorders for
generations to come.
We look forward to seeing you at either the American Thoracic Society’s Annual
International Conference in May or the American Academy of Sleep Medicine’s
Annual Meeting in June.
Kingman P. Strohl, MD
Interim Chief, Division of Pulmonary, Critical Care and Sleep Medicine
University Hospitals Case Medical Center
Professor of Medicine, Physiology & Biophysics, and Oncology
Case Western Reserve University School of Medicine
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University Hospitals Case Medical Center • 1-866-UH4-CARE
Dr. Reena Mehra
UH Case Medical Center’s Division of Pulmonary,
Critical Care and Sleep Medicine is a national
destination for referring physicians and
patients seeking the most advanced care and
groundbreaking treatments.
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Our physicians and researchers – who also serve as faculty at Case Western
Reserve University School of Medicine – are leaders in their respective fields,
and their ongoing clinical research programs push the boundaries of medical
progress. Our strong emphasis on translational research and personalized
medicine means newly developed treatments transfer more rapidly from the
research stage to life-enhancing patient care.
The School of Medicine is among the leading recipients of National Institutes
of Health (NIH) awards and ranks in the top 25 among U.S. research-oriented
medical schools as designated by U.S.News & World Report.
This unified dedication to clinical research and education has played a major role
in building UH Case Medical Center’s rich legacy of landmark medical innovation,
and continues to this day. Coupled with a commitment to implementing the
latest therapies and technologically advanced hospitals and community facilities,
UH Case Medical Center offers a depth of care and scope of
services unmatched by any other medical center in Ohio.
To Heal. To Teach. To Discover.
UH CASE MEDICAL CENTER
Among the nation’s leading academic
medical centers, University Hospitals
Case Medical Center is the primary
affiliate of Case Western Reserve
University School of Medicine.
With more than 1,000 registered beds,
UH Case Medical Center provides primary,
specialty and subspecialty medical and surgical
care. Located in the heart of Cleveland’s
University Circle on a beautiful 35-acre campus,
UH Case Medical Center includes general
medical, surgical and intensive care units
as well as three major hospitals:
University Hospitals
Seidman Cancer Center
University Hospitals
MacDonald Women’s Hospital
University Hospitals
Rainbow Babies & Children’s Hospital
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Division of Pulmonary,
Critical Care and
Sleep Medicine
Dr. Benjamin Young
At UH Case Medical Center, the
Division of Pulmonary, Critical Care
and Sleep Medicine is setting the
standard for care in the diagnosis and
treatment of asthma, chronic obstructive
pulmonary disease, sleep disorders,
interstitial fibrosis and pneumonia, as
well as pulmonary vascular disease,
cystic fibrosis (CF), interventional
bronchoscopy, lung transplantation,
lung cancer, pulmonary rehabilitation
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and critical care (sepsis, acute respiratory
distress syndrome [ARDS] and acute
lung injury [ALI]). Physicians keep a
patient’s individuality at the forefront
while working to restore or preserve
quality of life. Physicians consistently
form well-conceived plans to address
the underlying causes of disease, test
therapeutic effectiveness and optimize
patient care.
University Hospitals Case Medical Center • 1-866-UH4-CARE
The Sleep Medicine Program has
expanded to include outreach to
primary care practice management as
well as to the pre- and postoperative
management of patients with and
without obstructive sleep apnea. The
program will become a systemwide
center for sleep that will serve for
referral of complex sleep disorders,
innovation and education.
U.S.News & World Report has
consistently ranked the division in the
top 50 programs in pulmonary medicine
for the past five years – significant
against a backdrop of more than 2,000
pulmonary programs in the United
States. The division receives high marks
for shorter lengths of stay and nationally
low mortality rates. The division is
dedicated to transforming patient care at
an integrated and individualized level.
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Pulmonary,
Critical Care and
Sleep Medicine
Dr. Kingman Strohl
Leaders in the Field
The Division of Pulmonary, Critical Care
and Sleep Medicine is built upon a
foundation of physician-scientists who
specialize in researching, designing and
implementing treatments and therapies
to improve patients’ quality of life. These
highly trained specialists work jointly
with colleagues from multiple disciplines
to determine the best therapeutic
solutions for the individual patient while
maintaining recognition as leaders in their
specific fields.
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The team is led by Kingman Strohl,
MD, Interim Chief, Division of
Pulmonary, Critical Care and Sleep
Medicine, UH Case Medical Center;
Professor of Medicine, Physiology &
Biophysics, and Oncology at Case
Western Reserve University School of
Medicine; and Director of the Sleep
Disorders Program at the Louis Stokes
Cleveland VA Medical Center. Dr. Strohl’s
research interests are in genetic and
nongenetic mechanisms involved in
respiratory control relevant to sleep
apnea, pharmacologic modification
of central apneas and the effects of
early life on development of ventilatory
control. He has published original work
on sleep education, sleepiness in medical
training, and clinical decision-making
in sleep disorders. For more than 20
years, he has promoted excellence
and critical thinking in clinical training
in pulmonary and sleep medicine. Dr.
Strohl’s prominent recognition comes
through his research, publications and
presentations on sleep apnea, for which
he is internationally renowned. His
achievements include editing a number
of journals and publications, designing
data analysis software and participating
in national task forces on sleep apnea,
sleepiness and driving risk. Dr. Strohl is
a member of the American Society for
Clinical Investigation, and in 2008 he
received the Distinguished Achievement
Award from the American Thoracic
Society. For the past several years, he has
been a visiting professor to Germany,
China and Japan.
Rana B. Hejal, MD, is Director of the
Medical Intensive Care Unit (MICU),
UH Case Medical Center; and Associate
Professor of Medicine, Case Western
Reserve University School of Medicine.
For the past six years, the MICU
has received the prestigious Beacon
Award for Excellence in recognition of
teamwork in the delivery of care and
statistically low mortality rates. Dr. Hejal
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Leaders in the Field continued
has served as Director of the MICU
since 2006. As the Medical Director
of the bronchoscopy suite, she has
introduced advanced bronchoscopic
techniques to UH Case Medical Center.
Dr. Hejal and Mariana Petrozzi, MD,
Assistant Professor, Case Western
Reserve University School of Medicine,
developed a StepDown unit that is
facilitated by nurse practitioners to care
for the chronically critically ill. They have
also developed a comprehensive care
destination for patients who no longer
need intensive care, but whose recovery
is prolonged because of ongoing
ventilatory support. The MICU has
actively participated in clinical trials since
1994. One, the National Institutes of
Health (NIH) ARDS Clinical Network, was
established to hasten the development
of effective therapy for ARDS. The MICU
has participated in two published studies
and in one ongoing study of sepsis. The
National Heart, Lung and Blood Institute,
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NHLBI, initiated a clinical network to
carry out multicenter clinical trials of
ARDS treatments. The goal of the
network is to efficiently test promising
agents, devices or management
strategies to improve the care of patients
with ARDS. Dr. Hejal is also the training
program director for the pulmonary and
critical care medicine subspecialty. She
is the recipient of several Teacher of the
Year awards, most recently receiving
the department’s distinguished Master
Clinician Award in 2011.
Robert Schilz, DO, PhD, is Director
of Pulmonary Vascular Disease and
Lung Transplantation, UH Case Medical
Center; and Associate Professor of
Medicine, Case Western Reserve
University School of Medicine. Dr. Schilz
has participated in clinical and basic
research in pulmonary hypertension for
more than 15 years, with numerous
publications in the areas of pulmonary
hypertension, lung transplantation
University Hospitals Case Medical Center • 1-866-UH4-CARE
and advanced lung disease. He is a
committee member for the International
Society for Heart Lung Transplantation,
the American College of Chest Physicians
and the Ohio State Board of Hospitals.
Dr. Schilz is a member of the Scientific
Leadership Council for the Pulmonary
Hypertension Association. He also serves
on the Ohio Hospital Association task
force for Multidrug Resistant Organisms
and is on the Medical Advisory Board for
LifeBanc. He was recently elected to the
Scientific Leadership Committee for the
Pulmonary Hypertension Association and
is Chairman of its Education Committee
and a committee member for its Centers
of Excellence Initiative.
Reena Mehra, MD, MS, is Director
of the Sleep & Cardiovascular Risk
section of the division; and Associate
Professor of Medicine, Case Western
Reserve University School of Medicine.
Dr. Mehra has directed clinical trials to
determine how treatment of obstructive
sleep apnea might lower blood pressure.
This potentially could be achieved by
reducing inflammatory responses to
sleep fragmentation and hypoxemia.
She also examined the impact of sleep
apnea on complex cardiac arrhythmias,
recently observing the role of sleep
apnea in atrial fibrillation. Dr. Mehra has
been President of the Women’s Faculty
Association at the School of Medicine
and holds a joint appointment in the
Center for Clinical Investigation for
her expertise in clinical effectiveness
research. She received the 2012 Helen
Evans Mid-Career Faculty Award for fulltime women faculty members at Case
Western Reserve University and attended
the Women Faculty Professional
Development national course in 2012.
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To Heal. To Teach. To Discover.
Clinical Advances
Dr. Robert Schilz
Robert Schilz, DO, PhD, leads the section
on complex lung disease, along with
Mariana Petrozzi, MD, Lamia Ibrahim,
MD, and Jihane Faress, MD, all of whom
are Assistant Professors of Medicine,
Case Western Reserve University School
of Medicine. Individuals with pulmonary
vascular disease, adults who had complex
lung diseases as children, and patients
suffering from interstitial fibrosis and
pulmonary fibrosis are involved in clinical
trials and prepared for transplants by
some of the country’s leading experts
in these diseases. The division has
begun a major clinical trial in
pulmonary arterial hypertension.
Benjamin Young, MD, Assistant
Professor of Medicine, Case Western
Reserve University School of Medicine, and
Rana B. Hejal, MD, head the Lung Cancer
Clinic. They work closely with oncologists
at UH Seidman Cancer Center, using
interventional bronchoscopy and clinical
management skills to deliver comprehensive
respiratory care and rehabilitation,
highlighting the division’s integration with
experts in other areas of lung care.
The adult Division of Pulmonary, Critical
Care and Sleep Medicine collaborates in
both clinical management and research
for cystic fibrosis (CF) with the renowned
Department of Pediatrics at University
Hospitals Rainbow Babies & Children’s
Hospital and Case Western Reserve
University School of Medicine.
Elliott Dasenbrook, MD, Associate
Professor, Case Western Reserve University
School of Medicine, and Steven
Strausbaugh, MD, Assistant Professor,
Case Western Reserve University School
of Medicine, are co-Directors of the Cystic
Fibrosis Center as well as members of the
adult division. The School of Medicine and
department’s continued legacy of innovation
and research has helped to more than triple
the national average life expectancy of CF
patients – increasing from 11 years in 1970
to more than 38 years today.
The division’s Sleep Medicine Program
developed out of the division’s strength
in cardiopulmonary control to be an
Accreditation Council for Graduate Medical
Education (ACGME) accredited fellowship,
with added strength in research through an
NIH Training Award for epidemiology and
neurobiology. One focus is on cardiovascular
complications of obstructive sleep apnea,
led by Reena Mehra, MD, MS. The work of
Kingman Strohl, MD, has focused on the
principles and practice of therapy, including
the role of genetic predisposition.
The Amyotrophic Lateral Sclerosis (ALS)
Program joins specialists from University
Hospitals Neurological Institute’s
Neuromuscular Center, rehabilitative services
(such as physical therapy, occupational
therapy and speech therapy), surgery and
pulmonary medicine in order to optimize
patient care and comfort. Developed at
Case Western Reserve University School of
Medicine, diaphragmatic muscle pacing
is now an option in managing respiratory
failure in ALS patients. The NeuRx
Diaphragm Pacing System was pioneered at
UH Case Medical Center under the direction
of Raymond Onders, MD, Director of
Adult Minimally Invasive Surgery, UH Case
Medical Center; and Professor of Surgery,
Case Western Reserve University School
of Medicine, and Dr. Schilz. The device,
which has been approved by the U.S. Food
and Drug Administration, helps patients
to breathe and speak more normally, and
helps to stave off respiratory complications
during the progression of ALS. The device
was successfully used to treat the late actor
Christopher Reeve in March 2003.
All National Institutes of Health (NIH) funding for basic and clinical research
is awarded to the School of Medicine at Case Western Reserve University.
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To Heal. To Teach. To Discover.
As one of the nation’s leading academic medical centers, UH Case
Medical Center is committed to advancing the field of medicine through
a passionate commitment to training tomorrow’s clinicians.
In its teaching role, UH Case Medical Center helps provide medical
education in a wide variety of forums through Case Western Reserve
University School of Medicine, one of the nation’s leading medical schools.
Our physicians – who also serve as members of the school’s faculty –
are leaders in their respective fields and their ongoing clinical research
programs push the boundaries of medical progress throughout the world.
Academic Mission
division Highlights:
Division of Pulmonary, Critical Care and Sleep Medicine
Fellowships in the subspecialties of Pulmonary, Critical Care and Sleep Medicine are
available. To qualify, physicians must complete an Internal Medicine residency. Led by
Rana B. Hejal, MD, and Kingman Strohl, MD, respectively, the Pulmonary/Critical Care
Medicine program (UH Case Medical Center and VA Medical Center) is three years (four
fellows per year) with an optional fourth year for research. The one-year Sleep Medicine
fellowship (UH Case Medical Center, VA Medical Center and MetroHealth Medical Center)
offers a research program with training grant opportunities.
•
T he program is designed for clinicians with
a research focus to succeed as leaders in
academic medicine. It follows ACGME
guidelines and can result in board eligibility
in both Pulmonary Medicine as well as
Critical Care Medicine. The program
includes an 18-month clinical component
and an 18-month research component.
•
F ellows must meet the following
requirements to complete the program:
•
s the principal investigator of an
A
NIH T32 Training Grant in Sleep
Medicine Epidemiology and Neurobiology,
Dr. Strohl trains predoctoral and
postdoctoral individuals for careers in
basic and applied research. Reena Mehra,
MD, MS, was a past trainee. Brian Koo,
MD, Assistant Professor of Neurology,
Case Western Reserve University School
of Medicine, with a joint appointment
in Medicine, leads collaboration with
the Department of Neurology on the
epidemiology and mechanisms for restless
legs syndrome.
•
H Case Medical Center welcomed several
U
guest speakers in 2012. David Guidot,
MD, Associate Professor of Pulmonary and
Critical Care Medicine, and Director, Emory
Alcohol and Lung Biology Center and T32
Training Program, spoke on “HIV and
Alcohol as Risk Factors for Lung Disease.”
Martin Tobin, MD, Professor of Medicine,
Loyola University, discussed “Clinical
Decision Making: Applying Bayesian Logic
to Ventilator Weaning.”
- Write
a research proposal for divisional
review before their research time begins.
- Present
annual research conferences
to update the division on their
project’s progression.
Drs. Elliott Dasenbrook and Steven Strausbaugh
Medical students, residents and fellows benefit from hands-on instruction
from these leading medical experts and have access to a broad spectrum
of programs from which to pursue. Because UH Case Medical Center is the
primary affiliate of the School of Medicine, we offer an unrivaled depth
of resources and services – giving unparalleled access and exposure to the
latest technologies and medical breakthroughs.
This multidimensional approach and dedication to education by
UH Case Medical Center and Case Western Reserve University School
of Medicine play a major role in further enhancing our rich tradition
of developing medicine’s future leaders.
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- G
ive
an abstract presentation at a
national meeting.
•
F ellows on a research track must write
an American Lung Association Fellowship
grant when their third year begins.
•
F or some, a fourth research year is
offered postfellowship. It is based upon
a fellow’s commitment to an academic
career, achievements during the research
program and development throughout
the research project.
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To Heal. To Teach. To Discover.
Research
•
Drs. Kingman Strohl and Jonathan Baskin
UH Case Medical Center’s
physician-scientists are
leaders in their respective
fields, and their ongoing
clinical research programs
are at the leading edge of
medical progress. A strong
emphasis on translational,
or “bench-to-bedside,”
research means that new
and innovative treatments
and technologies transfer
more rapidly from the
research laboratory to
actual patient care.
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•
S leep-related Respiratory and
Electrophysiological Predictors of Atrial
Fibrillation, led by Reena Mehra, MD, MS:
This NIH-funded study at Case Western
Reserve University is on the growing rate
of atrial fibrillation (AF), which is not fully
explained by known risk factors. Sleepdisordered breathing (SDB) is common
in patients with cardiovascular disease
(CVD), and its attendant hypoxemia and
autonomic dysfunction create a milieu
that is likely to enhance AF propensity.
Thus, SDB may represent a novel target for
AF prevention and treatment strategies.
The study will utilize electrocardiogram
monitoring, patient questionnaires,
polysomnography, blood pressure,
anthropometry measurements and blood
testing, and home monitoring through a
continuous positive airway pressure (CPAP)
with a nasal mask. Case Western Reserve
University School of Medicine received
funding Aug. 14, 2011.
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•
P hase II Trial of Sleep Apnea Treatment
to Reduce Cardiovascular Morbidity,
conducted at the UH Case Medical
Center site and led by Dr. Mehra: This
NIH-funded, multicenter, randomized,
controlled trial evaluated the utility of a
novel application of nocturnal supplemental
oxygen in treating patients at high risk for
CVD events with sleep apnea. It identified
pathophysiological pathways that may be
improved by blunting the physiological
stress of intermittent hypoxemia compared
with improving airway patency. The study
will lay groundwork for a definitive Phase
III study addressing the role of sleep apnea
interventions in CVD risk reduction. Funding
for the study, performed at Case Western
Reserve University and UH Case Medical
Center, was received Sept. 25, 2009. The
trial is currently in data analysis mode and is
closed to enrollment.
xidative Stress in Sleep Apnea and Cardiac
O
Disease (Mentored Patient-Oriented Clinical
Research Career Development Award):
Also led by Dr. Mehra, this NIH-funded
study will assess changes in oxidative stress
and intermediate cardiovascular measures,
including vascular stiffness in patients
with SDB who receive CPAP and sham
CPAP in a randomized parallel design
study. Funding for the study, performed
at Case Western Reserve University School
of Medicine, was received Aug. 29, 2006.
It is currently in data analysis mode and
is closed to enrollment.
•
espiratory Rhythmogenesis: A Genomic
R
Approach led by Kingman Strohl, MD:
This study, funded by the VA Research
Service, will utilize recombinant inbred
mice strains to increase the genomic
understanding of unstable breathing,
and uncover genomic mechanisms and
pathways underlying ventilatory responses
to hypoxia and hypercapnia, in wakefulness
and the different stages of sleep. Funded by
the VA on Jan. 1, 2012, the study is being
performed at the Louis Stokes Cleveland VA
Medical Center.
•
S TAR Trial: UH Case Medical Center
participates in a pivotal clinical study to
evaluate the safety and effectiveness of
hypoglossal nerve stimulation therapy to
reduce obstructive sleep apnea (OSA), led
All National Institutes of Health (NIH) funding for basic and clinical research is awarded
to the School of Medicine at Case Western Reserve University.
The commitment to exceptional patient care begins with revolutionary
discovery. University Hospitals Case Medical Center is the primary affiliate
of Case Western Reserve University School of Medicine, a national leader
in medical research and education and consistently ranked among the
top research medical schools in the country by U.S.News & World Report.
Through their faculty appointments at Case Western Reserve University
School of Medicine, physicians at UH Case Medical Center are advancing
medical care through innovative research and discovery that bring the
latest treatment options to patients.
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To Heal. To Teach. To Discover.
by principal investigator Dr. Strohl. His
collaborator is Jonathan Baskin, MD,
Department of Otolaryngology, UH Case
Medical Center, and Assistant Professor
of Otolaryngology and Biomedical
Engineering, Case Western Reserve
University School of Medicine. The
Stimulation Therapy for Apnea Reduction
(STAR) Trial will evaluate an implantable
electronic stimulation device called Inspire™
Upper Airway Stimulation therapy, designed
to deliver mild stimulation to the main
nerve of the tongue (hypoglossal nerve)
on each breathing cycle during sleep. The
stimulation is intended to restore tone
to the muscles during sleep that control
the base of the tongue, preventing the
tongue from collapsing and obstructing the
airway. The study was funded by the Inspire
Medical Group on June 1, 2011.
•
E radication of Persistent MRSA and
Persistent MRSA Eradication Protocol, led
by Elliott Dasenbrook, MD: Funded by
NIH on Feb. 10, 2010, and Dec. 6, 2011,
respectively, these research studies consider
whether CF patients and CF animal models
with methicillin-resistant staphylococcus
aureus (MRSA) in the respiratory tract have
lower survival rates than those without the
drug-resistant bacteria. The study’s initial
findings, published in the Journal of the
American Medical Association, suggested
the need for more aggressive treatment
of CF patients who are persistently MRSA
positive and stressed the importance
of following current infection control
guidelines to minimize transmission of
MRSA. The studies are conducted at
UH Rainbow Babies & Children’s Hospital
and Case Western Reserve University.
•
Weaning and Variability Evaluation (WAVE)
Trial data collection site, led by Frank
Jacono, MD, Assistant Professor of
Medicine, Case Western Reserve University
School of Medicine: A collaboration with
Philips Healthcare and three Canadian sites
that uses variability in heart and breathing
rate to measure the impact of and
predict weaning success from mechanical
ventilation. The division is the only U.S.
site participating in the trial, which is
supported in part by the Medical Research
Trial of Canada. This demonstration project
started in 2011 and is based at UH Case
Medical Center.
•
ICU of the Future led by Dr. Jacono:
Funded by the Medical Research Council
of Canada, Dr. Jacono collaborates with
colleagues in the UH Neurological Institute
(Michael DeGeorgia, MD, Director,
Neurocritical Care Center; Maxeen Stone
and John A. Flower Chair in Neurology, and
Professor, Case Western Reserve University
School of Medicine), and the Department
of Electrical Engineering and Computer
Science (Ken Loparo, PhD) at the Case
School of Engineering at Case Western
Reserve University, to test the feasibility of
using continuously measured physiologic
information collected at the bedside to
forecast the trajectory of health and disease
in patients. Employing computational
strategies used in weather forecasting, the
initial targets are patients hospitalized with
stroke, sepsis and ARDS. Based at Case
Western Reserve University, funding was
received Aug. 17, 2012.
•
ultiscale Model of Neural Control of
M
Breathing, led by Ted Dick, PhD, Professor,
Case Western Reserve University School
of Medicine: This is a collaborative grant
Research
Dr. Rana Hejal with patient
from NIH across three institutions that
addresses the impact of sepsis on the cell,
the cardiorespiratory system and mortality.
The hypothesis is that when sepsis starts
it is localized and its progress results from
an unchecked cascade of inflammatory
mediators that remotely affects several
brain systems. The result is a transformation
of physiologic control systems to an
unregulated state. Severity is then the result
of this dysregulation at both local and
system levels. The work at Case Western
Reserve University School of Medicine is
directed at cardiopulmonary coupling as
a marker of health, evolving disease and
recovery. Funding began Oct. 26, 2010.
•
Impact of the Orexin Receptor 2 (OXR2)
on Respiratory Rhythmogenesis: Based at
the Louis Stokes Cleveland VA Medical
Center, this Phase I NIH STTR award is a
collaboration between Dr. Strohl and
BIOFUNC LLC, a biomedical company, and
utilizes a preclinical model of sleep apnea to
test the effects of modulation of the OXR2
system. Demonstration of efficacy would
be the first step in a drug discovery process
looking for small molecules that could be
orally effective against sleep apnea. Funding
to Case Western Reserve University School
of Medicine began Dec. 16, 2011.
•
linical Research Network for the Treatment
C
of ALI and the Adult Respiratory Distress
Syndrome (ARDSnet): This is a multicenter
collaboration funded by NIH to test therapy
for acute intensive illnesses. Rana B. Hejal,
MD, leads the UH Case Medical Center site,
where the project is based. Prior studies
have confirmed the role of low tidal volume
ventilation in the management of ARDS,
the lack of effectiveness of steroids in
ALI and the positive impacts of aspiration
prevention measures and early ambulation
in the management of intubated
patients. Currently, there is a prospective,
randomized, multicenter trial of aerosolized
albuterol versus placebo for the treatment
of ALI.
All National Institutes of Health (NIH) funding for basic and clinical research is awarded
to the School of Medicine at Case Western Reserve University.
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University Hospitals Case Medical Center
One of America’s First
Academic Medical Centers
University Hospitals
Case Medical
Center has been
at the forefront
of patient care,
physician education
and medical
research for nearly
150 years.
Founded after the Civil War as a place of healing, the
institution embraced a broader role as medical science
advanced. By the turn of the twentieth century, a
modern general hospital was enhanced by specialty
facilities for women, children and infants. An affiliation
with the medical school of what was then Western
Reserve University – today Case Western Reserve
University – formed one of the first true academic
medical centers in the United States, as University
Hospitals of Cleveland joined Johns Hopkins Hospital
and Massachusetts General in combining the training of
young physicians and the pursuit of laboratory research
with delivery of the most advanced patient care.
In 1931, new facilities brought University Hospitals
and the School of Medicine onto the same medical
campus in University Circle. Over the years the complex
continually expanded both its physical presence and the
scope of its professional activities, adding diagnostic
and treatment capabilities as well as top-flight
physicians and surgeons.
Today, as the primary affiliate of
Case Western Reserve University
School of Medicine, University Hospitals
Case Medical Center advances care
through a commitment to clinical
and translational research in a
large academic medical campus
that incorporates nationally acclaimed
hospitals including UH Rainbow Babies
& Children’s Hospital, UH Seidman
Cancer Center and UH MacDonald
Women’s Hospital.
In 2011, University Hospitals put the
finishing touches on Vision 2010,
a five-year, $1.2 billion strategic plan,
which included building the new
freestanding 150-bed inpatient and
outpatient UH Seidman Cancer Center;
the Center for Emergency Medicine and
Marcy R. Horvitz Pediatric Emergency
Center at UH Case Medical Center;
the Quentin & Elisabeth Alexander
Neonatal Intensive Care Unit at
UH Rainbow Babies & Children’s
Hospital, which was ranked fifth in the
nation for newborn care by U.S.News
& World Report; the UH Ahuja Medical
Center, a 435,000-square-foot hospital
and 60,000-square-foot Kathy Risman
Pavilion, a medical office building
in Beachwood, Ohio; and several
outpatient health centers throughout
Northeast Ohio. A key strategy of Vision
2010 involved the implementation of a
new state-of-the-art Electronic Medical
Record System throughout the system.
University Hospitals Institutes
University Hospitals multidisciplinary institutes help ensure
the best possible outcomes for our patients by bringing
together a broad range of physicians, nurses, ancillary staff and
administrators. Their collaborative efforts lay the groundwork
for new standards in patient care, accelerate clinical research
and create community-based education programs. The
institutes bring UH expertise in diagnosing and treating
individuals’ health problems to UH locations throughout
Northeast Ohio. UH Case Medical Center institutes include:
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Harrington Discovery Institute at University Hospitals Case Medical Center
University Hospitals Digestive Health Institute
University Hospitals Ear, Nose & Throat Institute
University Hospitals Eye Institute
University Hospitals Harrington Heart & Vascular Institute
University Hospitals Neurological Institute
University Hospitals Transplant Institute
University Hospitals Urology Institute
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Our Commitment
to Quality
The passage of health care reform legislation is
changing the way care is delivered, bringing a new
focus to optimizing the quality of patient care while
controlling costs and using resources efficiently.
At UH Case Medical Center, the emphasis on quality
is not an outgrowth of new health care legislation,
but an integral part of our patient care tradition.
And that is precisely why
we have launched the
UH Quality Institute.
As an innovative integrated delivery system, UH offers
patients the latest technology and treatment methods.
By pursuing the newest and best technologies, hiring
and retaining highly skilled staff, and promoting a culture
of safety and excellence, UH has forged an impressive
quality record.
The UH Quality Institute shares the results of our ongoing
efforts to provide safe, effective, patient-centered care
to our patients and families. This includes a website that
provides information about our quality awards, patient
safety and quality measures. Through this quality data,
we are able to present documentation and further
evidence of the top-notch care we provide.
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UH Case Medical Center
the Nation’s Leader in Quality
The 2012 American Hospital Association-McKesson Quest for
Quality Prize named UH Case Medical Center the top hospital
in the nation for its leadership and innovation in quality
improvement and safety.
UH Case Medical Center was selected by a multidisciplinary
committee of health care quality and patient safety experts.
Awarded annually, the prize is supported by a grant from the
McKesson Corp., a national health care services company based
in San Francisco. The criteria for the 2012 award include the
demonstration of an organizational commitment to and progress
in achieving the Institute of Medicine’s six quality aims – safety,
patient-centeredness, effectiveness, efficiency, timeliness and
equity. One goal of the award is to honor hospitals that are
making progress in quality improvement with models that
can be replicated by others in the hospital field.
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Harrington Discovery Institute
at University Hospitals Case Medical Center
Harrington Discovery Institute is led by Director Jonathan Stamler,
MD. Dr. Stamler holds the Robert S. and Sylvia K. Reitman Family
Foundation Distinguished Chair in Cardiovascular Innovation at
both University Hospitals and Case Western Reserve University
School of Medicine. He also serves as Director for the Institute
for Transformative Molecular Medicine, Professor of Medicine
and Professor of Biochemistry at Case Western Reserve University
School of Medicine.
Mukesh K. Jain, MD, is the Chairman of the Executive Committee
for Harrington Discovery Institute. He also serves as Chief Research
Officer, University Hospitals Harrington Heart & Vascular Institute
at University Hospitals Case Medical Center, and holds the
Ellery Sedgwick Jr. Chair and is a Distinguished Scientist. In addition,
Dr. Jain serves as Director, Case Cardiovascular Research Institute,
and is a Professor of Medicine at Case Western Reserve University
School of Medicine.
Drs. Jonathan Stamler
and Mukesh Jain
Harrington Discovery Institute
is a national model dedicated
to physician-scientists, enabling
them to transform their extensive,
cross-cutting knowledge into
therapies and medicines that
improve patients’ lives.
The institute will support physician-scientists as they undertake
fundamental research uniquely capable of changing the standard of
care, generating insights into the clinical condition and developing
new treatments. As part of its mission, Harrington Discovery Institute
will enable physician-scientists to participate in and transform the
drug development cycle within academia.
The open design of Harrington Discovery Institute will allow for
collaboration with major academic medical centers and nonprofit
foundations across the country, build a national community for
physician-scientists and advance academic medicine’s involvement
in drug discovery and development.
To learn more about the annual
Harrington Scholar-Innovator Grant
program and view a list of grant recipients,
visit HarringtonDiscovery.org.
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Clinicians and Scientists at UH Case Medical Center and
Case Western Reserve University School of Medicine
Division of Pulmonary,
Critical Care and Sleep
Medicine
Leadership
Kingman P. Strohl, MD
Interim Chief, Division of
Pulmonary, Critical Care
and Sleep Medicine
Professor
Rana Hejal, MD
Director, Medical Intensive
Care Unit
Associate Professor
Physician Faculty (Adult)
Physician Faculty (Pediatric)
Community Specialists
Thomas E. Dick, PhD
James Chmiel, MD
John Baron, MD
Professor
Associate Professor
Clinical Instructor
Pingfu Feng, MD, PhD
Daniel Craven, MD
Associate Professor
Assistant Professor
Akhil Bindra, MD
Samuel Friedlander, MD
Elliott Dasenbrook, MD
Clinical Assistant Professor
Assistant Professor
Lamia Ibrahim, MD
Pamela B. Davis, MD, PhD
Assistant Professor
Professor
Frank Jacono III, MD
Dorr G. Dearborn, MD, PhD
Assistant Professor
Professor
Nizar Nader, MD
Michael Passero, MD
Syed Razmi, MD
Jonathan Castro, MD
Russell Ciufo, MD
Jeffrey Renston, MD
Associate Professor
Professor
David Rosenberg, MD
Clinical Assistant Professor
Donald Epstein, MD
Clinical Assistant Professor
Theodore Sher, MD
Clinical Assistant Professor
Timothy Taylor, MD
Anthony DiMarco, MD
Colleen G. Lance, MD
Benjamin Gaston, MD
Reena Mehra, MD
Assistant Professor
Director, Sleep and
Cardiovascular Risk
Associate Professor
Hugo Montenegro, MD
Division Chief, Pulmonary
Diseases, University Hospitals
Rainbow Babies &
Children’s Hospital
Professor
Robert Hostoffer Jr., DO
Clinical Assistant Professor
Harish Kakarala, MD
Gregory Watts, MD
Clinical Senior Instructor
Robert Schilz, DO, PhD
Michael Nochomovitz, MD
Danielle Goetz, MD
Kent Knauer, MD
Clinical Assistant Professor
David Weiner, MD
Clinical Assistant Professor
Director, Pulmonary Vascular
Disease and Lung Transplantation
Associate Professor
Professor
Clinical Assistant Professor
Mariana Petrozzi, MD
Assistant Professor
Mohammed Shatat, MD
Assistant Professor
Richard Silver, MD
Associate Professor
Erik van Lunteren, MD
Professor
Benjamin Young, MD
Assistant Professor
Assistant Professor
Meeghan A. Hart, MD
Assistant Professor
Michael W. Konstan, MD
Professor
Richard Lavi, MD
Clinical Senior Professor
Ann Marie Leano, MD
Assistant Professor
Andrew Liu, DO, PhD
Clinical Assistant Professor
Ross E. Myers, MD
Kar-Ming Lo, MD
Laura Milgram, MD
Assistant Professor
Carol L. Rosen, MD
Professor
Kristie Ross, MD
Assistant Professor
Lawrence Martin, MD
Clinical Professor
Arthur Molinoff, MD
Timothy Murray, MD
Robert Stern, MD
Professor
Steven Strausbaugh, MD
Assistant Professor
Physicians receive their academic appointments and their accompanying titles
from Case Western Reserve University School of Medicine.
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UH Case Medical Center
is among the nation’s best
hospitals, ranked in all 12
methodology-ranked specialties.
University Hospitals Case Medical Center
Cancer
Cardiology & Heart Surgery
Diabetes & Endocrinology
Ear, Nose & Throat
Gastroenterology
Geriatrics
Gynecology
Nephrology
Neurology & Neurosurgery
Orthopedics
Pulmonology
Urology
To refer a patient or learn more about the
Division of Pulmonary, Critical Care and
Sleep Medicine at UH Case Medical Center
call 1-866-UH4-CARE (1-866-844-2273)
or visit UHhospitals.org
© 2012 University Hospitals BRA 00180