1/30/2012 Chapter 5 Tissues Tissue Types Cells are the building blocks of tissues The human body has four tissue types: – Epithelial – Connective – Muscular – Nervous Epithelial Tissue Epithelial tissue • covers the body • lines all cavities • composes the glands It has neither blood vessels nor any extracellular substances between the cells 1 1/30/2012 Epithelial Tissue Epithelial types are identified by both the number of cell layers and the shape of the cells in the upper layer There are eight basic types of epithelium – six identified by both the number of cells and their shape – two named for the type of cell found in them • transitional • pseudostratifed Epithelial cells can be flattened, cube-like, or columnar Each shape mirrors the function of the tissue Epithelial Tissue Epithelial Tissue Flattened cells, reminiscent of fried eggs, are called squamous cells – squamous epithelium is thin enough to form a membrane through which compounds can move via diffusion Cuboidal and columnar epithelia are plumper and usually compose mucous membranes Simple epithelium has one layer of cells and usually functions as a diffusion or absorption membrane – the lining blood vessels – the lining of respiratory membranes Stratified epithelia have many layers of cells and are designed for protection – outer layer of skin – salivary gland ducts 2 1/30/2012 Epithelial Tissue Glands are composed of epithelial tissue Glands are classified by how their secretions are released – glands that secrete into ducts are exocrine glands • salivary glands, sweat glands – endocrine glands have no ducts, they secrete directly into the surrounding extracellular fluid • endocrine glands secrete hormones that are then picked up by the bloodstream and carried throughout the body • Adrenal glands, thyroid glands, pituitary glands Connective Tissue Connective tissue connects the structures of the body • • it binds, supports, and anchors the body It is the most abundant type of tissue in the body Soft connective tissue examples include parts of our skin, tendons, and blood vessels – it has a matrix composed of semi-fluid substance – it has fibroblasts that secrete fibers, and white blood cells that fight infection Connective Tissue 3 1/30/2012 Connective Tissue Connective Tissue Connective Tissue Connective tissue is composed of cells suspended in a noncellular matrix The matrix, or “ground substance,” is secreted by the connective tissue cells • • the matrix determines the characteristics of the connective tissue it contains fibers of collagen (for strength) and elastin (for flexibility, stretch, and recoil) 4 1/30/2012 Connective Tissue Cartilage, bone, blood, and lymph are types of specialized connective tissues Cartilage is a unique connective tissue because it is avascular – other types of connective tissue all have rich blood supplies Chondrocytes, the cartilaginous cells, secrete a gel-like matrix that eventually surrounds and imprisons them, segregating them from direct contact with one another or any nutrient supply Cartilage heals slowly because nutrients must diffuse through the matrix to the chondrocytes – nutrients cannot reach the cells directly via the bloodstream – osteoarthritis is difficult to treat because cartilage is avascular and therefore does not respond quickly to medications Connective Tissue Connective Tissue 5 1/30/2012 Connective Tissue Connective Tissue The most common type of cartilage is hyaline cartilage Hyaline cartilage covers the ends of bones, allowing them to slide against one another without damage – it is also found in your nose During development, the entire skeleton is modeled in hyaline cartilage, which then ossifies A second kind of cartilage is elastic cartilage – elastic cartilage comprises the outer ear and the epiglottis The fibrocartilage matrix is packed with collagen fibers – it is found where extra strength is needed – it cushions knee joints and the disks between the vertebrae Connective Tissue Blood and lymph are considered fluid connective tissues because their matrix is not a solid Blood is composed of specialized cells that are carried in the fluid matrix, or plasma – blood’s main function is to transport nutrients, gases, hormones, and wastes Lymph is derived from the interstitial fluid that bathes the cells – It is collected in the lymphatic vessels 6 1/30/2012 Bone Bone is a hard mineralized tissue found in the skeleton Bone cells secrete an osteoid substance that eventually hardens and surrounds the cells in an ossified matrix. – this “osteoid ground substance” includes proteins, water, calcium, and phosphorous salts – once the matrix ossifies, the cells remain in contact with one another through small channels called canaliculi Adipose Tissue Adipose tissue contains cells that are specialized for lipid storage (fat cells) Adipose tissue does not have an extensive extracellular matrix Cellulite “bumps” on the skin indicate where the adipose matrix is connected to the skin – adipose cells within the fibrous matrix can expand with the swelling of the fat droplets they contain, while the matrix fibers cannot stretch as far. – different stretching capacities of these two components of adipose tissue form dimples on the skin Muscular Tissue Muscular tissue provides movement and heat The function of muscular tissue is to contract – cells get shorter, generating force and often movement There are three types of muscular tissue are • • • skeletal muscle smooth muscle cardiac muscle. 7 1/30/2012 Muscular Tissue Muscular Tissue Muscular Tissue 8 1/30/2012 Skeletal Muscle Skeletal muscle is the tissue that makes up the muscles – it is highly organized, with cells lying parallel to each other – skeletal muscle moves limbs and stabilizes our trunk Smooth Muscle Smooth muscle lines hollow organs such as the blood vessels and the digestive tract – Smooth muscle cells are short, cylindrical cells that taper at both ends and have only one nucleus – They are not striated, and are not under voluntary control Cardiac Muscle Cardiac (heart) muscle has short, branched, striated cells, with one nucleus at the center of each cell Specialized communication junctions called intercalated discs facilitate the heartbeat by transmitting the signal to contract Intercalated discs are gap junctions where the closely knit cell membranes help to spread the contraction impulse while also binding the cells together 9 1/30/2012 Nervous Tissue Nervous tissue responds to the environment by detecting, processing, and coordinating information Nervous tissue contains two categories of cells: neurons and neuroglia – Neuroglia are the supporting cells of nervous tissue (“glia” means “glue”) • they improve nutrient flow to the neurons, provide physical support, remove debris, and provide electrical insulation Nervous Tissue Nervous Tissue Nerves are clusters of neurons and their projections, sheathed in connective tissue – nerves exist in the body's periphery, and are therefore a part of the peripheral nervous system Sensory nerves conduct sensory messages from the body's sensory organs to the spinal cord, which routes the information to the brain Motor nerves carry impulses that cause muscular movement or glandular secretion from the spinal cord to the muscles and glands The brain and spinal cord contain neurons that receive and integrate information and stimulate motor neurons to fire – these information-processing neurons occur in the central axis of the body, so they comprise the central nervous system 10 1/30/2012 Cellular Organization • Cellular organization or hierarchy, is visible in all life forms – Atom – Molecule – Organelle – Cell – Tissue – Organ – Organ system – Organism Organ Systems There are 11 organ systems in the human body – – – – – – – – – – – integumentary - protecting and covering skeletal - support muscular - movement and heat production nervous - sensing and responding cardiovascular - transporting fluids and oxygen respiratory - gas exchange urinary - fluid balance endocrine - regulating sequential growth and development digestive - obtaining nutrients lymphatic - immunity reproductive systems - continuation of species Ten of these systems help maintain homeostasis, while the reproductive system maintains the human population Organ Systems 11 1/30/2012 Organ Systems Organ Systems Organ Systems 12 1/30/2012 Organ Systems Anatomical Position Used as a standard, anatomical position allows us to make sense of directional terms Body Cavities 13 1/30/2012 Body Cavities The body has two large cavities, the ventral and dorsal cavities The thoracic cavity includes the chest area and houses the heart, lungs, vessels, and lymphatic system The “guts” are found within the abdominal cavity, which is lined with peritoneum The organs of the urinary system and the reproductive system are located in the pelvic cavity. The dorsal body cavity includes the cranial cavity housing the brain, and the vertebral cavity which contains the spinal cord The integumentary system: • Includes the skin and accessory organs such as hair, nails and gland • The skin has two main regions called the epidermis and the dermis • Under the skin there is a subcutaneous layer between the dermis and internal structures where fat is stored • Is important for maintaining homeostasis What are the functions of the integumentary system 1. Protects the body from physical trauma, invasion by pathogens and water loss 2. Helps regulate body temperature 3. Allows us to be aware of our surroundings through sensory receptors 4. Synthesizes chemicals such as melanin and vitamin D 14 1/30/2012 There are two regions of the skin • • Epidermis Dermis The epidermis: • • • The thin, outermost layer of the skin Made of epithelial tissue Cells in the uppermost cells are dead and become filled with keratin thus acting as a waterproof barrier Langerhans cells are a type of white blood cell that help fight pathogens Melanocytes produce melanin that lend to skin color and protection for UV light Some cells convert cholesterol to vitamin D • • • What you need to know about skin cancer? • 2 of the 3 types that arise in the epidermis: • • • Basal cell carcinoma is the most common yet least deadly form of skin cancer Melanoma is the most deadly form of skin cancer but is the least common What can you do to help prevent this? • • • • Stay out of the sun between 10am-3pm Wear protective clothing (tight weave, treated sunglasses, widebrimmed hat) Use sunscreen with an SPF of at least 15 and protects from UV-A and UV-B rays Don’t use tanning beds 15 1/30/2012 What might skin cancer look like? 16