PRODUCT #: A5376
NAME: ACETYLSALICYLIC ACID CRYSTALLINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:28AM
Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178
Phone: 314-771-5765
Aldrich Chemical Co., Inc.
1001 West St. Paul
Milwaukee, WI 53233
Phone: 414-273-3850
Fluka Chemical Corp.
1001 West St. Paul
Milwaukee, WI 53233
Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - CATALOG #:
A5376
NAME:
ACETYLSALICYLIC ACID CRYSTALLINE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - CAS #:
50-78-2
MF: C9H8O4
EC NO: 200-064-1
SYNONYMS
ACENTERINE * ACESAL * ACETICYL * ACETILSALICILICO * ACETILUM
ACIDULATUM * ACETISAL * ACETOL * ACETONYL * ACETOPHEN * ACETOSAL *
ACETOSALIC ACID * ACETOSALIN * O-ACETOXYBENZOIC ACID * 2ACETOXYBENZOIC ACID * ACETYLIN * 2-(ACETYLOXY)BENZOIC ACID *
ACETYLSAL * ACETYLSALICYLIC ACID (ACGIH) * ACETYLSALICYLSAURE (GERMAN)
* ACIDO ACETILSALICILICO (ITALIAN) * ACIMETTEN * ACIDE
ACETYLSALICYLIQUE (FRENCH) * ACIDO O-ACETIL-BENZOICO (ITALIAN) *
ACIDUM ACETYLSALICYLICUM * ACISAL * ACYLPYRIN * ASA * A.S.A. * A.S.A.
EMPIRIN * ASAGRAN * ASPERGUM * ASPIRDROPS * ASPIRIN * ASPIRINA 03 *
ASPRO CLEAR * ASTERIC * AC 5230 * BENASPIR * BENZOIC ACID, 2(ACETYLOXY)- (9CI) * BIALPIRINIA * CAPRIN * O-CARBOXYPHENYL ACETATE *
COLFARIT * CONTRHEUMA RETARD * DELGESIC * DOLEAN PH 8 * DURAMAX * ECM
* ECOTRIN * EMPIRIN * ENDYDOL * ENTERICIN * ENTEROSARINE * ENTROPHEN *
GLOBOID * HELICON * IDRAGIN * ISTOPIRIN * KAPSAZAL * KYSELINA 2ACETOXYBENZOOVA (CZECH) * KYSELINA ACETYLSALICYLOVA (CZECH) *
MEASURIN * MEDISYL * MICRISTIN * NEURONIKA * NOVID * POLOPIRYNA *
RHEUMIN TABLETTEN * RHONAL * SALACETIN * SALCETOGEN * SALETIN *
SOLPYRON * TRIPLE-SAL * XAXA * YASTA * ZORPRIN *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - LABEL PRECAUTIONARY STATEMENTS
TOXIC
TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
CALIF. PROP. 65 REPRODUCTIVE HAZARD.
POSSIBLE SENSITIZER.
TARGET ORGAN(S):
BLOOD
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
AMOUNTS OF WATER.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
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PRODUCT #: A5376
NAME: ACETYLSALICYLIC ACID CRYSTALLINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:28AM
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - CHEMICAL SAFETY GOGGLES.
RUBBER GLOVES.
NIOSH/MSHA-APPROVED RESPIRATOR.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - APPEARANCE AND ODOR
WHITE CRYSTALLINE POWDER
PHYSICAL PROPERTIES
MELTING POINT:
138 C TO 140 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
STRONG ACIDS
STRONG BASES
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - ACUTE EFFECTS
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERTAIN
SENSITIVE INDIVIDUALS.
CHRONIC EFFECTS
OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH
LABORATORY ANIMALS.
TARGET ORGAN(S):
BLOOD
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PRODUCT #: A5376
NAME: ACETYLSALICYLIC ACID CRYSTALLINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:28AM
RTECS #: VO0700000
SALICYLIC ACID, ACETATE
TOXICITY DATA
ORL-CHD LDLO:104 MG/KG
LANCAO 2,809,1952
UNR-MAN LDLO:294 MG/KG
85DCAI 2,73,1970
ORL-RAT LD50:200 MG/KG
34ZIAG -,67,1969
IPR-RAT LD50:340 MG/KG
NYKZAU 62,11,1966
REC-RAT LD50:790 MG/KG
34ZIAG -,67,1969
ORL-MUS LD50:250 MG/KG
ARZNAD 5,572,1955
IPR-MUS LD50:167 MG/KG
USXXAM #4376771
SCU-MUS LD50:1020 MG/KG
CPBTAL 28,1237,1980
ORL-DOG LD50:700 MG/KG
ARZNAD 21,719,1971
IVN-DOG LD50:681 MG/KG
AIPTAK 149,571,1964
ORL-RBT LD50:1010 MG/KG
GTPZAB 24(3),43,1980
ORL-GPG LD50:1075 MG/KG
JAPMA8 47,479,1958
ORL-HAM LD50:3500 MG/KG
ATSUDG 7,365,1984
ORL-MAM LD50:1750 MG/KG
IJMRAQ 81,621,1985
TARGET ORGAN DATA
SENSE ORGANS AND SPECIAL SENSES (TINNITUS)
BEHAVIORAL (ALTERED SLEEP TIME)
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (TREMOR)
BEHAVIORAL (CHANGE IN MOTOR ACTIVITY)
BEHAVIORAL (COMA)
BEHAVIORAL (ANALGESIA)
LUNGS, THORAX OR RESPIRATION (ACUTE PULMONARY EDEMA)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY STIMULATION)
GASTROINTESTINAL (NAUSEA OR VOMITING)
GASTROINTESTINAL (OTHER CHANGES)
LIVER (HEPATITIS: HEPATOCELLULAR NECROSIS, DIFFUSE)
LIVER (LIVER FUNCTION TESTS IMPAIRED)
KIDNEY, URETER, BLADDER (CHANGES IN TUBULES)
KIDNEY, URETER, BLADDER (URINE VOLUME DECREASED OR ANURIA)
KIDNEY, URETER, BLADDER (HEMATURIA)
BLOOD (HEMORRHAGE)
MUSCULO-SKELETAL (OTHER CHANGES)
PATERNAL EFFECTS (SPERMATOGENESIS)
PATERNAL EFFECTS (TESTES, EPIDIDYMIS, SPERM DUCT)
MATERNAL EFFECTS (MENSTRUAL CYLCE CHANGES OR DISORDERS)
MATERNAL EFFECTS (PARTURITION)
EFFECTS ON FERTILITY (PRE-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (OTHER MEASURES OF FERTILITY)
EFFECTS ON EMBRYO OR FETUS (EXTRA EMBRYONIC STRUCTURES)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
EFFECTS ON EMBRYO OR FETUS (FETAL DEATH)
EFFECTS ON EMBRYO OR FETUS (OTHER EFFECTS TO EMBYRO OR FETUS)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (EYE, EAR)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CRANIOFACIAL)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (BODY WALL)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CARDIOVASCULAR SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (BLOOD AND LYMPHATIC SYSTEMS)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (OTHER DEVELOPMENTAL ABNORMALITIES)
EFFECTS ON NEWBORN (STILLBIRTH)
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PRODUCT #: A5376
NAME: ACETYLSALICYLIC ACID CRYSTALLINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:28AM
EFFECTS ON NEWBORN (LIVE BIRTH INDEX)
EFFECTS ON NEWBORN (OTHER NEONATAL MEASURES OR EFFECTS)
EFFECTS ON NEWBORN (BIOCHEMICAL AND METABOLIC)
EFFECTS ON NEWBORN (OTHER POSTNATAL MEASURES OR EFFECTS)
NUTRITIONAL AND GROSS METABOLIC (DEHYDRATION)
NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE INCREASE)
BIOCHEMICAL EFFECTS (OTHER)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - EUROPEAN INFORMATION
TOXIC
R 23/24/25
TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
R 63
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36/37/39
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
S 22
DO NOT BREATHE DUST.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
ACGIH TLV-TWA 5 MG/M3
DTLVS* TLV/BEI,1996
OEL-AUSTRALIA:TWA 5 MG/M3 JAN 1993
OEL-BELGIUM:TWA 5 MG/M3 JAN 1993
OEL-DENMARK:TWA 5 MG/M3 JAN 1993
OEL-THE NETHERLANDS:TWA 5 MG/M3 JAN 1993
OEL-RUSSIA:STEL 0.5 MG/M3 JAN 1993
OEL-SWITZERLAND:TWA 5 MG/M3 JAN 1993
OEL-UNITED KINGDOM:TWA 5 MG/M3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO ACETYLSALICYLIC ACID-AIR:10H TWA 5 MG/M3
NIOSH* DHHS #92-100,1992
NOHS 1974: HZD 84517; NIS 12; TNF 1746; NOS 16; TNE 10452
NOES 1983: HZD X1189; NIS 1; TNF 27; NOS 1; TNE 191; TFE 82
NOES 1983: HZD 84517; NIS 9; TNF 491; NOS 22; TNE 10776; TFE 6083
EPA GENETOX PROGRAM 1988, NEGATIVE: SPERM MORPHOLOGY-MOUSE
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: MAMMALIAN MICRONUCLEUS
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PRODUCT #: A5376
NAME: ACETYLSALICYLIC ACID CRYSTALLINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:28AM
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
U.S. INFORMATION
CALIFORNIA PROPOSITION 65:
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE FEMALE REPRODUCTIVE TOXICITY.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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