Delaney Sullivan
dsull@stanford.edu
Undergraduate Student, Stanford University
April 12, 2015
Photo 51
Photo 51
Rosalind Franklin
X-ray crystallography
Nobel Prize in Physiology or Medicine, 1962
James Watson
Francis Crick
Maurice Wilkins
Review: What is the function of DNA?
DNA is our genetic material
The Central Dogma of Molecular Biology
The Central Dogma of Molecular Biology
“DNA makes RNA makes protein”
The structure of DNA
Left-handed vs. Right-handed Helix
Forms of DNA: A, B, Z
A
B
Z
(Image source: http://commons.wikimedia.org/wiki/File%3AA-B-Z-DNA_Side_View_Transparent.png)
B-DNA
(Image source: http://www.pbs.org/wgbh/nova/body/DNA-photograph.html)
Base Pairs
Base Pairs
What’s wrong with these figures?
Chromatin
Chromatin Packing
Epigenetic Regulation: Lysine (De)acetylation
(Image source: Fundamentals of Chromatin)
Epigenetic Regulation: The Histone Code
(Image source: Molecular Biology of the Cell, 4th ed.)
Epigenetic Regulation: The Histone Code
(Image source: Molecular Biology of the Cell, 4th ed.)
Epigenetic Regulation: The Histone Code
(Image source: Molecular Biology of the Cell, 4th ed.)
Epigenetic Regulation: The Histone Code
(Image source: Molecular Biology of the Cell, 4th ed.)
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