{1} Last Update: 12/13/14 Our Father’s Design through The Human Body Student Materials Notebook This notebook contains thirty-two links to web-based RWT1 video lessons content. Additionally, over 500 pages of excellent supplement materials are provided. Also included are over 500 links to extended course materials. Finally, sixteen module tests and five exams are integrated for student content assessment. This product is designed to be used with The Human Body: Fearfully and Wonderfully Made, 1st Edition, (ECHB) Apologia textbook and its Solutions Manual. {2} The notebook is licensed to you, the enrolled student. You may not use it for other students in your family unit or outside your family. You are paying tuition to use this notebook. The notebook is yours to keep. You may not share its contents. Your brothers and sisters are not covered under your family license, nor are your friends, co-op group, classmates, etc. Every person using the materials needs to pay the required tuition. The items in the notebook are copyrighted and may not be distributed to or reproduced for those not covered under your license. By payment of your tuition, you acknowledge that Red Wagon Tutorials owns all rights, titles, and interests in and to all video lectures and course materials - all of which are protected by copyright laws and shall not be resold, shared, copied, recorded, or reproduced by any means for any purpose. {3} Our Father’s Design through The Human Body: Student Materials Notebook By Steven M. Rosenoff We would like to acknowledge the inspiration of Dr. Jay L. Wile in the production of this product. As my former employer and longtime friend, his encouragement and mentorship helped make this publication possible. Although he did not directly contribute to this work, nor has he received any financial reward from it, we feel that his influence in our lives is worthy of mention and that he deserves our utmost respect as a co-laborer in Christ. Table of Contents {4} Our Father’s Design through The Human Body: Student Materials Notebook Published by Red Wagon Tutorials, Inc. 9316 Lewis Dr. NE Lacey, WA. 98516 www.redwagontutorials.com Copyright © 2014 Red Wagon Tutorials, Inc. All rights reserved Manufactured in the United States of America First Printing 2014 ISBN: 978-1-4675-6490-8 Printed by Red Wagon Tutorials, Inc., Lacey WA. {5} Our Father’s Design through The Human Body: Student Materials Notebook Table of Contents Assignment Supplement ..............................................................................................................9 Course Schedule........................................................................................................................ 24 Parent Agreement ...................................................................................................................... 33 Module 1................................................................................................................................... 37 Lesson 1: ............................................................................................................................... 37 Answers & Links:.............................................................................................................. 43 Lesson 2: ............................................................................................................................... 57 Answers & Links:.............................................................................................................. 63 Formal Report Example #1:................................................................................................... 75 Module 1 Test Review: ......................................................................................................... 79 Module 2..................................................................................... 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Steps for Success These are the steps taken by successful students last year for completing the required Module work. Please note: these are the steps I am suggesting you take also! As per stated policy, any assignment submitted is assumed to be supervised and proctored by the student's parent. First Week: 1. Read the assigned reading indicated in your syllabus, including labs, before coming to class. 2. Answer the On Your Own questions when you come to them. (These are not turned in. They are for your benefit. The answers are at the end of your Module.) 3. Attend Class: ask questions about reading assignment and labs. Participate, listen and learn. 4. Perform the labs included in the week’s reading. Write the required informal lab report for each lab completed. Place them in your notebook for safe keeping. (If you are doing the optional microscope experiments these should be completed also.) Second Week: 1. Read the assigned second reading, including labs, before coming to class. 2. Answer the On Your Own questions when you come to them. (Again, do not turn these in.) 3. Attend Class: ask questions about reading assignment and labs. Participate, listen, and learn. 4. Perform labs included in the week’s reading. Write the required informal lab reports. (If you are doing the optional microscope experiments these should be completed also.) 5. Answer the Study Guide questions at the end of the module. (This is an open book assignment. I have provided you an example of a completed assignment below.) 6. Parents use your Solutions Manual to correct your student’s Study Guide answers. 7. Have the student correct any error they may have made in the Study Guide assignment. Third Week: 1. Overlap week. You will need to begin the next Module in your book during this week. Follow the steps above. {10} 2. Ask questions in class about your Study Guide grade. I will give you a review for your Module Test during class this week. If you miss class this week, you will need to listen to the class recording for Test prep assistance. 3. Take the online Module Test by the date indicated in your syllabus. This assignment is closed book and closed notes. The Module Test will be forwarded to me automatically once you click on “Finished” on the Student Portal site. 4. Parents MUST sign the bottom of the test and be present during the testing session. Fourth Week: 1. Ask questions in class about your Module Test grade and your finished experiment reports. 2. Continue on with next Module work. B. Assignment Guidelines 1. Formal Experiment Reports MUST BE TYPED (MS Word 2010 docx or Adobe PDF, Times New Roman, 12 font, black print on a white background, 1” margins, single-spaced) AND SPELL CHECKED before the report is forwarded to me as an e-mail attachment: the e-mail address for submission is ccr101@comcast.net. The document file size cannot exceed 1 MB. The subject line of the e-mail MUST read Human Anatomy Draft Report for a draft paper and Human Anatomy Final Report for a final assignment. There is one formal report required per quarter. 2. Formal Experiment Report assignment requirements are outlined in detail in your Assignment Supplement. Remember, I expect honors biology students to have had two years prior practice writing experiment reports. I do allow revisions of the experiment report and will tell your student how to improve their assignment before final report submission. If you plan to use graphs or other graphics as part of your report Observations section, YOU MUST E-MAIL these to me as an e-mail attachment: MS Word 2010 docx format, Rich Text Format, Adobe PDF, or as a whiteboard presentation. As stated in the Assignment Supplement, when seeking help from someone or quoting facts from a book, internet source, or other media, you must include them in your bibliography in the required format. 3. Module Tests are taken online through the Student Portal site: http://www.redwagontutorials.com/php/. Module Test assignments ARE CLOSED BOOK AND CLOSED NOTES assignments. As per stated policy, any assignment submitted is assumed to be supervised and proctored by the student's parent. A parent’s digit signature is required on the bottom of the Test and Exam. I have has a zero tolerance policy toward cheating or plagiarism. Vocabulary words for the Module (e.g. those found in question #1 of the Study Guide) MUST BE SPELLED CORRECTLY if used to answer a test question. USING SPELL CHECK DURING A TEST IS NOT ALLOWED. {11} 4. All Test assignments, except your semester exams, must be completed within 60 minutes of logging onto the Student Portal site. Semester exams must be completed within 90 minutes. After 60 or 90 minutes, depending on the assignment, the Student Portal WILL DISCONNECT YOU AND NOT FORWARD your assignment, which could result in a zero being given on an assignment. 5. Upon submission of any assignment through the Student Portal, the Portal site will forward a copy to my e-mail address and forward a receipt copy to your e-mail address of record on the site. IT IS YOUR RESPONSIBILITY TO OBTAIN A RECEIPT FROM THE PORTAL COMPUTER AND TO MAINTAIN THE CORRECT E-MAIL ADDRESS on the Portal computer. The assignment receipt is your proof that the assignment was submitted on time and in good order. I will ask to see the receipt copy for any assignment when there is a question about the timely submission of the assignment: NO RECEIPT COPY MEANS NO CREDIT GIVEN. 6. Students must be disciplined enough to submit required work on time. As per Stated policy, I will deduct 10% per day from the score received on the assignment on all late work, including the Parent Notebook Report, unless the lateness results from personal illness, family emergency, or computer problem of a non-reoccurring nature. In these instances, I will grant full points. A schedule for the course, providing due dates for all assignments for the entire year, has been forwarded to you. If you are leaving on vacation or some other personal choice holiday, please adjust your study schedule to submit the assigned work before leaving. I will always accept an assignment early. I am available during my office hours to help you complete assignments before the due date, when and if necessary, during the school year. 7. All class assignments are due by 6:00 PM, Eastern Time, on the date indicated in the Course Schedule. The Student Portal time stamp on your work is the final authority on whether something is submitted on time or not. NOTE: 6:01 PM, Eastern Time, starts a new day, and I will subtract 10% if your work arrives at or after that time. 8. Students should keep hard copies of all their work (labs, study guides, tests, etc.), not just computer saved work. Doing so will allow the student to keep a good portfolio of their class assignments should they be asked to demonstrate their work at some later date. Please note, I do not maintain copies of a student's work beyond the end of the school year. I will maintain a copy of a student's final semester grades for seven years beyond the end of our class together. C. Study Guide Assignment The following is an example of the completed Study Guide assignment. The completed assignment is parent corrected or student self-correct by the due date indicated in your Course Schedule. Your student’s completed assignment document should be handwritten or typed and saved in your student’s notebook. The Study Guide assignment, the On Your Own questions, the practice test that is the Solutions Manual, the lecture notes, and the text itself are all sources of Module Test and Exam questions. {12} As per stated policy, any assignment submitted is assumed to be supervised and proctored by the student's parent. Mr. Adam Apple Advanced Biology Module 1 Study Guide Answers to #1: Please be sure to answer all the study guide questions as complete sentences. a. Gross anatomy is the study of the macroscopic structures of an organism. b. Microscopic anatomy is the study of the microscopic structures of an organism. c. Physiology is the study of the functions of an organism and its parts. d. Histology is the study of tissues. e. An organ is a group of tissues specialized for a particular function. f. Tissues are groups of cells specialized for a particular function. g. Homeostasis is a state of equilibrium in the body with respect to its functions, chemical levels, and tissues. h. An effector is a structure in the body that can change the value of a variable. i. Selective permeability is the ability to let certain materials in or out while restricting others. j. Endocytosis is the process by which large molecules are taken into the cell. k. Exocytosis is transportation of material from inside the cell to outside the cell. 2. If this course taught only the name of each organ, it would be an anatomy course. Anatomy concentrates on the structures of an organism. Physiology studies how an organism and its parts function. 3. An organism has the following organization: organism, organ systems, organs, tissues, cells, organelles, and molecules. 4. When an organ is put under a microscope, tissues, cells, and organelles are seen. You cannot see chemicals with a 40x,100x, 400x, 1000x microscope. You can see organisms and organ systems without the aid of a microscope. 5. The four types of tissue are nervous tissue, muscle tissue, connective tissue, and epithelial tissue. 6. The types of tissues are identified below: a. Epithelial tissue makes up the lining of many organs, including blood vessels. b. Muscles, like the trapezius muscle, are made of muscle tissue. c. Joint cartilage is an example of connective tissue. d. The brain, spinal cord, etc. are made of nervous tissue. {13} 7. Homeostasis is threatened by stress. 8. A negative feedback system would cause the heart rate to decrease, because negative feedback systems produce effects that are the opposite of the stress. A positive feedback system would cause the heart rate to increase, because positive feedback systems produce effects that are the same as that of the stress. 9. The nervous system and endocrine system are the organ systems most involved with negative feedback. The nervous system sends the messages to the control center, which is also often a part of the nervous system. The endocrine system also functions as a control center. 10. When one exercises, the following happens: a. The stress is a decrease in blood glucose level. Remember, stress is what takes us away from homeostasis. The drop in blood glucose level was a departure from homeostasis. b. The control center is the pancreas. It is the one that monitors blood glucose level and determines whether or not something should be done. c. The effector is the liver. The liver caused more glucose to be released in the blood, which was the negative response to the blood glucose level decrease. d. The endocrine system is involved, because hormones were released. Those hormones caused the effector to do its job. 11. The organelles and their main function are given below: ORGANELLE Nucleus Plasma membrane Ribosomes Rough endoplasmic reticulum Smooth endoplasmic reticulum Golgi apparatus Secretory vesicle Lysosome Mitochondria Cilia Centrioles FUNCTION Contains DNA Holds the cell together and controls entry and exit of substances Synthesize proteins Intercellular transport and synthesis of proteins Intercellular transport and synthesis of carbohydrates and lipids Packages chemicals for secretion Secretion Breaks down proteins, polysaccharides, nucleic acids, and lipids Produce energy for the cell Movement Spindle formation for mitosis and meiosis 12. There are three nucleotides in a codon. 13. An anticodon must bind to a codon. Thus, the first nucleotide on the anticodon must be able to bind to the nucleotide on the codon. Only thymine or uracil bind to adenine. RNA does not {14} have thymine, and an anticodon is on tRNA. Thus, it must be uracil. In order for a nucleotide to have been in the codon, mRNA must have been able to bind to DNA at that point. Once again, only thymine and uracil bind to adenine. DNA does not have uracil. Thus, thymine must have been on the DNA at that point. 14. Mitosis occurs in this order: prophase, metaphase, anaphase, telophase. 15. The “X” shape occurs only when the chromosomes have been duplicated and the duplicates have not been separated from each other. This is only during prophase and metaphase. In anaphase and telophase, the chromosomes have been separated from their duplicates. 16. The fact that phospholipids have a polar head and a nonpolar tail keeps them oriented properly. Even if disturbed, they will reorganize themselves so that the heads are pointed either into the cell or towards the outside, and the tails are pointed towards each other. 17. A glycoprotein allows for identification. 18. A receptor protein takes in messages from other cells. 19. The “fluid” is the fatty part of the membrane, which is composed of phospholipids. Mosaic refers to the fact that there are several different proteins scattered throughout. 20. A substance can dissolve through the phospholipids, it can enter through a channel protein, it can enter using a carrier protein, or it can enter through endocytosis. You could have listed charged channel proteins, but that’s just a variation on channel proteins. Also, you could have listed both pinocytosis and phagocytosis, but endocytosis covers them both. That’s how we can cram six methods of entering the cell down into just four. 21. The substances would get through the plasma membrane in the following ways: a. Water is small enough to enter the cell through a channel protein. b. A protein can only enter through pinocytosis. c. Ions are small enough to go enter through channel proteins, but they use charged channel proteins. d. A monosaccharide is like glucose. Thus, it will need a carrier protein because of its size. e. An invading bacterium must be engulfed using phagocytosis. f. A lipid is a fat, which will dissolve through the phospholipids. 22. Regardless of concentrations, pinocytosis is always an active transport process. {15} 23. The glucose moved according to the dictates of diffusion. Thus, this is passive transport, and no ATP was expended. D. Informal Laboratory Report Format The experiments in this course are designed to be done as you are reading the text. I recommend that you keep a notebook of these experiments. This notebook serves two purposes. First, as you write about the experiment in the notebook, you will be forced to think through all of the concepts that were explored in the experiment. This will help you cement them into your mind. Second, certain colleges might actually ask for some evidence that you did, indeed, have a laboratory component to your advanced biology course. The notebook will not only provide such evidence but will also show the college administrator the quality of your advanced biology instruction. I recommend that you perform the experiments in the following way: When you get to an experiment, read through it in its entirety. This will allow you to gain a quick understanding of what you are to do. Once you have read the experiment, start a new page in your laboratory notebook. The first page should be used to write down all of the data taken during the experiment. What do I mean by “data”? Any observations or measurements you make during the experiment are considered data. Thus, if you see an organism during an experiment, you need to either describe it or draw it. If you measure the length of something during the experiment, that is part of the experiment's data and should be written down. In addition, any data analysis that you are asked to do as a part of the experiment should be done on this page. When you have finished the experiment and any necessary analysis, write a brief report in your notebook, right after the page where the data and calculations were written. The report should be a brief discussion of what was done and what was learned. You should not write a step-by-step procedure. Instead, write a brief summary that will allow someone who has never read the text to understand what you did and what you learned. PLEASE OBSERVE COMMON SENSE SAFETY PRECAUTIONS! The experiments in this course are no more dangerous than most normal, household activity. Remember, however, that the vast majority of accidents do happen in the home. Chemicals used in the experiments should never be ingested; hot beakers and flames should be regarded with care; and all experiments should be performed while wearing eye protection such as safety glasses or goggles. E. Formal Laboratory Report Format Standard six-step, typewritten formal laboratory write-up should include the following: (You do not have to follow this format for your penciled, handwritten, laboratory notebook. There is information on how to prepare an informal lab notebook report included above.) You are required to produce one formal report per quarter. Formal Experiment Reports MUST BE TYPED (MS Word 2010 docx or Adobe PDF, Times New Roman, 12 font, black print on a {16} white background, 1” margins, single-spaced) AND SPELL CHECKED before the report is forwarded to me as an e-mail attachment: the e-mail address for submission is ccr101@comcast.net. The document file size cannot exceed 1 MB. The subject line of the email MUST read Human Anatomy Draft Report for a draft paper and Human Anatomy Final Report for a final assignment. There is one formal report required per quarter. Your formal report must be formatted as follows and included the following sections: Name Date Title of the Experiment A. Purpose You must tell what the experiment is about and what area it will test. Background on the area is expected. (In other words, provide details about what is being experimented on.) You must use your textbook and two outside resources preparing your report background. You must also include a statement of what the experiment hope to show and why this topic is of interest. You must also include a hypothesis statement in the standard “If, then” format for scientific research work. First person pronouns are not used in scientific writing. B. Equipment Provide a complete list of equipment necessary to conduct the experiment. Equipment should be listed in a 1, 2, 3, 4, 5, etc., fashion down the page. C. Procedure Provide a complete list of the procedure used. Procedure should be written in a cookbook fashion and be numbered 1, 2, 3, 4, 5, etc., fashion down the page. D. Observations Provide a detailed, objective report of observations -- what was seen, heard, felt, tasted, smelled - when the experiment was performed. Charts and graphs which provide detail are encouraged, but these do not take the place of the narrative observations. E. Conclusions Provide analysis of the experiment: try to explain what was seen, heard, felt, tasted, or smelled while the experiment was happening. Be sure to provide ways that the experiment could be improved if the experiment was done again and any ideas for further research the experiment might have generated. Note: there are ALWAYS ways to improve how an experiment is done and ideas further research generated. {17} F. Bibliography If you seek help from someone or quote facts from a book, internet source, or other media you should include them in bibliography in using the format I provide. You are required to research two outside resources other than your textbook and use them in the background of your report. Additionally, you must cite your textbook and me as a “class source” or “personal interview” on every lab report. The completed Word 2010 docx or Adobe PDF document of the formal experiment report should be printed and saved to your student’s notebook. The completed and spell-checked Experiment Report is then forwarded to me as an e-mailed attachment. An example of a completed advanced biology experiment follows. Please note -- I expect you as incoming advanced biology students to be able to produce a quality lab report similar to the one below: Mr. ID 10/24/14 Human Skin Examination A. Purpose: The object of this experiment is to examine in greater detail the layers that make up the skin on our bodies. The experiment involves examining a prepared slide of the human skin, drawing and documenting what was seen, and distinguishing and identifying the five layers of the epidermis. It will show the physical differences between those layers in the epidermis in a way that will not quickly be forgotten. It will provide a better understanding of the layering of the skin in our bodies. The skin on a human body is composed of two major layers: the dermis and the epidermis. The dermis is made up of dense irregular connective tissue while the epidermis is composed of four or five layers of epithelial tissue (stratum basale, stratum spinosum, stratum granulosum, stratum lucidum found only in thick skin, and stratum corneum) (Wile). However, even though there is such complexity and design in the epidermis including 4 or 5 distinct layers, the epidermis is extremely thin and ranges in thickness from 1.4 mm to .07 mm (Saunders). The thickest skin is usually found on the soles of the feet and palms of the hands while the thinnest skin can be found on the eyelids (Brannon). This is the result of the wonderful design of God. The skin is designed to be thicker where it is rubbed and used most often and thinner where it does not experience such treatment. This experiment hopes to show the physical and visible differences between the different layers in the epidermis. Each layer of the epidermis has unique qualities and capabilities that set it apart from the rest of the layers. Layers range in thickness from one cell to many cells, they range from alive cells that constantly reproduce to dead cells that flake off. In one layer the epithelial cells gobble up parts of other cells because they contain specific chemicals, in another {18} they “commit suicide” to help protect the human body as a whole. By examining in detail a slide of actual human skin this experiment hopes to discover the physical attributes of each layer that enable it to perform its duties. This topic is very important to science for many reasons. First of all the skin provides a huge amount of protection to our bodies from the hordes of harmful invaders (e.g. viruses, radiation, and bacteria) that would love to get in and destroy us. The better scientists can understand the individual layers of the skin and how they function separately as individual layers the better they can understand how the skin functions as a whole. Additionally, the more scientists discover about the functions of the skin the better people will know how to take care of their bodies. Hypothesis: If the slide examined is properly stained and the nuclei of cells in stratum basale and stratum spinosum are visible, then cells undergoing different phases of mitosis will be seen. B. Equipment: 1. Microscope 2. Prepared slide: human skin (not the one with follicles) C. Procedure: 1. Place the prepared slide under the microscope at 40x magnification. Look for the dark, wiggly line near the top of the tissue. That's the line which separates the dermis from the epidermis. Center that line and increase magnification to 100x. 2. Focus, center the line, and increase magnification to 400x. 3. Focus again, and, using Figure 3.4 as a guide, try to identify each layer of the epidermis. 4. Notice the change in cell size and shape in the different regions. 5. Notice also the dermal papillae and how their size varies. 6. Now begin to scan the slide. Note how the thickness of the layers changes across this tissue sample. 7. Draw at least two fields of the scope where the thickness varies greatly. 8. Put everything away. D. Observations: 1. The most visible (even at 40x magnification) and obvious layer was the stratum granulosum. 2. The cells of the stratum granulosum were all a very dark color compared to the other cells and stood out in a straight dark line across the slide. 3. The precise parameters of the dermal papillae became easily distinguishable at 100x magnification. 4. The dermal papillae were all different shapes and sizes and no two looked alike. 5. The Stratum basale was only one cell thick and closely outlined the dermal papillae. 6. The cells in stratum basale were taller and skinnier than the cells in the other layers and very tightly packed together also each cell in this stratum made contact with the dermal papillae 7. In the stratum basale, one cell was found that had the regular dark spot for the nucleus as well as two much smaller and fainter dark spots, one on each side of the nucleus. {19} 8. The stratum spinosum was the most irregularly shaped of all the layers, its cells were more compact than the cells in the dermis but were the most spread out of all the cells in the epidermis. 9. In stratum spinosum a few cells were observed that each had two small dark spots on opposite sides of the cell (whereas most cells only had one dark spot indicating the nucleus) 11. The stratum granulosum was mostly two cells thick however in some places it was only one cell thick and in other places it was three cells thick. 12. Only a few of the cells in stratum granulosum had distinguishable nuclei. 13. The stratum lucidum was not present (indicating that the skin on the slide was not thick skin). 14. The stratum corneum was the thickest of all the layers but its cells were the most flattened and least distinguishable of all the cells in the epidermis. 15. No nuclei were seen in the cells of the stratum corneum. 16. On the outside edge of the stratum corneum, several cells were seen that appeared to be flaking off. 17. The nuclei of the cells in the dermis appeared to be narrow and elongated, while the nuclei of the cells in the first two layers of the epidermis were round in shape. E. Conclusions: The data collected seemed to support the hypothesis. The cells in the stratum spinosum that were seen to have two smaller nuclei probably were undergoing the telophase of mitosis at the time the sample was taken. The cell in the stratum basale that appeared to have one nucleus with two much smaller dark spots on each side of it could be a cell undergoing the metaphase of mitosis (the phase where the centrioles gather on opposite sides of the nucleus to pull the duplicated chromosomes apart). The cells on the slide were distinguishable and the nuclei were properly stained and certain cells were observed that seemed to be undergoing different phases of mitosis. One way to improve the experiment would be to use a microscope that can achieve higher magnification (such as 1000x) than the 400x magnification used. This would allow for a better examination of the individual cells and their nuclei to be able further to distinguish the differences between the cells in the different layers. Another way to improve the experiment would be to use a microscope projector to make it easier to sketch what was seen on the slide. Another thing one could do to enhance the experiment would be to examine slides of skin from different parts of the body. For example one could look at the skin from the eyelids (the thinnest skin) and the skin from the soles of the feet (some of the thickest skin) to compare and contrast them. Future studies could try to determine how the cells in the lower epithelial layers know when to undergo mitosis. The cells could be studied while they still live and function or the genetic code could be analyzed to see if it controls the mitosis rate of the skin cells, or the different organelles inside each cell could be analyzed to see if they have anything to do with the timing. If it turned out that the cells were triggered somehow to reproduce, then even further studies could be done to determine if it were possible to use the same mechanism to trigger other cells to reproduce that don’t normally reproduce (such as stable cells or permanent cells). And those studies could eventually lead to major breakthroughs in the field of medicine. {20} F. Bibliography: Brannon, Heather. Definition of epidermis. 2008. Domain: http://dermatology.about.com Document: /cs/skinanatomy/g/epidermis.htm Rosenoff, Steven. Classroom/Internet Lecture. October 2013. Saunders. Dorland's Medical Dictionary for Health Consumers. Elsevier, Inc. Domain: http://medical-dictionary.thefreedictionary.com Document: /epidermis Wile, Dr. Jay. L. and Shannon, Marilyn M. The Human Body Fearfully and Wonderfully Made. 5th Edition. Apologia Educational Ministries, Inc. 2009 An example of lab report grading criteria follows: A. Purpose (10 points possible) (10 points earned) You must include the following five paragraphs (minimum) and present them in this sequence: Para 1 - What the experiment is about: the objective Para 2 - Background information on the experiment from your textbook and two other sources. You may need more than one paragraph here, which is okay Para 3 - What the experiment hopes to show Para 4 - Why this topic is of interest to science Para 5 - A hypothesis statement in the proper "If, then" format SUPERIOR (I will include comments in all capitals here. Please note: I am not shouting at your student! I am simply trying to set my comments apart from the template information. Remember: no personal pronouns can be used in your lab report!) B. Equipment (5 points possible) (5 points earned) You may copy/paste this from the online textbook, but you must make the following changes to the textbook list: 1. Provide a complete list of equipment necessary to conduct the experiment. If you substituted or changed anything, please list it here also. 2. Equipment should be listed in a 1, 2, 3, 4, 5, etc., fashion down the page; not in the A, B, C, D, etc., fashion used in your textbook. PERFECT. C. Procedure (5 points possible) (5 points earned) {21} You may copy/paste this from the online textbook, but you must make the following changes to the textbook list: 1. Provide a complete list of the procedure used. If you change any, be sure to note it. 2. Procedures should be written in a cookbook fashion 3. Procedures must be numbered 1, 2, 3, 4, 5, etc., down the page, use a, b, c, d, etc. for subitems PERFECT. D. Observations (10 points possible) (10 points earned) 1. Provide a detailed, objective report of observations -- what you saw, heard, felt, tasted, smelled, etc -- when the experiment was performed. (Charts and graphs which provide detail are encouraged. These MUST be e-mailed as an attachment to me as stated in your assignment guidelines.) A numbered list of observations works well here: a well-detailed list may be as many as 10 observations or more long. You can also provide me with a narrative of your observations in paragraph form if you desire. GREAT JOB. E. Conclusions (10 points possible) (10 points earned) You must include: Para 1. An analysis of the data Para 2. Ways to improve the experiment Para 3. Ideas the experiment generated for further research OUTSTANDING. F. Bibliography (10 points possible) (10 points earned) You must include the following four citations in alphabetical order: Cit 1 - A reference for me as a class lecture or interview note in proper format as given in examples Cit 2 - A reference for your textbook in proper format as given in examples Cit 3 - A reference for your first outside resource Cit 4 - A reference for your second outside resource WONDERFUL BIBLIOGRAPHY ASSIGNMENT GRADE: 50/50 100% Excellent. {22} As per stated policy, any assignment submitted is assumed to be supervised and proctored by the student's parent. F. Laboratory Notebook Requirements Students should keep hard printed copies of all their work (labs, study guides, tests, etc.), not just computer saved work. I would divide the notebook into sixteen sections, one for each Module of the Wile’s text. Doing so will allow the student to keep a good portfolio of their class assignments should they be asked to demonstrate their work at some later date. Please note, I do not maintain copies of a student's work beyond the end of the school year. I will maintain a copy of a student's final semester grades for seven years beyond the end of our class together. Please note that some of the experiments require long periods of time to complete. As I do not set the lab schedule in your home school, you will need to look ahead and adjust your lab time accordingly. I require a Parent Notebook Report to be submitted at the end of first and second semesters which states how many of the required experiments have been completed by your student. The student should have the following completed and in his or her notebook for each semester listed: As per stated policy, any assignment submitted is assumed to be supervised and proctored by the student's parent. First Semester: Experiment 2.1 Experiment 2.2 Experiment 3.1 - Formal Report Required Experiment 3.2 Experiment 4.1 Experiment 4.2 Experiment 5.1 Experiment 7.1 – Formal Report Required Second Semester: Experiment 9.1 Experiment 9.2 Experiment 11.1 Experiment 11.2 Experiment 11.3 – Formal Report Required Experiment 12.1 Experiment 13.1 Experiment 13.2 Experiment 14.1 – Formal Report Required Experiment 15.1 No assigned lab work due for Module 16. {23} G. Module Tests and Exams Module Tests and Semester Exams are taken online through the Student Portal site. Module Tests and Semester Exams ARE CLOSED BOOK AND CLOSED NOTES assignments. As per stated policy, any assignment submitted is assumed to be supervised and proctored by the student's parent. A parent’s digit signature is required at the bottom of the Test or Exam. I have has a zero tolerance policy toward cheating or plagiarism. Vocabulary words for the Module (e.g. those found in question #1 of the Study Guide) MUST BE SPELLED CORRECTLY if used to answer a test or an exam question. USING SPELL CHECK DURING A TEST IS NOT ALLOWED. All Module Test assignments must be completed within 60 minutes of logging onto the Student Portal site. Semester exams must be completed within 90 minutes. After 60 or 90 minutes, depending on the assignment, Student Portal WILL DISCONNECT YOU AND NOT FORWARD your assignment, which could result in a zero being given on an assignment. Please time yourself during your Module Test or Semester exam to ensure completion within the time limit. Table of Contents Start {24} RED WAGON TUTORIALS Course Schedule Welcome to Advanced Biology class. I am excited about the new school year for two reasons: (1) our class will be live-feed Internet. Unlike some Internet courses that require you to send in assignments, which I would score then return, you and I will be communicating directly with each other on at least a weekly basis. This arrangement gives us greater opportunity to interact and learn from each other because we will be together for ninety minutes each week; (2) our curriculum will be challenging and exhilarating. Sixteen major topics will be covered during the course of this year. These units are all outlined in the following syllabus and in the book Human Body: Fearfully and Wonderfully Made, 1st Edition, by Dr. Jay Wile and Marilyn M. Shannon, M.A., which will also be our classroom text. As a former medical and industrial research scientist, you can be certain I will bring a depth of knowledge to the topics we will study together. I am eager to share my experience with you in a tutorial capacity. This document in conjunction with stated requirements, the Assignment Supplement, and the Parent Agreement (e-mailed to you at registration) outline and detail the requirements for the Advanced Biology Course. Schedule: FIRST SEMESTER Module 1: An Organizational Overview and Some Review Class discussions: Week of 9-8, Week of 9-15 For the first class meeting (Week of 9-8), you need to have read up to and including the section called "A Review of Cell Structure and Organelle Function." For the second class meeting (Week of 9-15), you need to have finished reading Module 1. Formal Experiment report to be turned in to Mr. Rosenoff: None {25} (All required experiments in the textbook are to be completed as they are encountered. Experiment reports are to be handwritten in the informal format provided at the front of your textbook, completed on notebook paper, and kept in a 3-ring binder. I will ask each parent at the end of each semester for a count of the number of experiments completed during the semester. Failure to complete the all the required experiments may keep your student from continuing on into the next semester of science.) Assignments Due: Module Study Guide: Required Experiments: Online Module Test: Due by 9-17 None Due by 9-24 Module 2: Histology: The Study of Tissues Class discussions: Week of 9-22, Week of 9-29 For the first class meeting (Week of 9-22), you need to have read up to and including the section called "Glandular Epithelium." For the second class meeting (Week of 9-29), you need to have finished reading Module 2. Formal Experiment report to be turned in to Mr. Rosenoff: None Assignments Due: Module Study Guide: Required Experiments: notebook Online Module Test: Due by 10-1 Due by 10-8: Experiment 2.1 and Experiment 2.2 informal reports in Due by 10-8 Module 3: Skin and Bones – The Integumentary and Skeletal Systems Class discussions: Week of 10-6, Week of 10-13 For the first class meeting (Week of 10-6), you need to have read up to and including the section called "Skin Glands." For the second class meeting (Week of 10-13), you need to have finished reading Module 3. Formal Experiment report to be turned in to Mr. Rosenoff: {26} Experiment 3.1 Draft Report Assignments Due: Module Study Guide: Due by 10-15 Required Experiments: Due by 10-22: Experiment 3.1 Draft Report to Mr.R and Experiment 3.2 informal report in notebook Online Module Test: Due by 10-22 Module 4: Skeletal System Histology and Movement Class discussions: Week of 10-20, Week of 10-27 For the first class meeting (Week of 10-20), you need to have read up to and including the section called "Bone Homeostasis." For the second class meeting (Week of 10-27), you need to have finished reading Module 4. Formal Experiment report to be turned in to Mr. Rosenoff: Experiment 3.1 Corrected Report Assignments Due: Module Study Guide: Due by 10-29 Required Experiments: Due by 11-5: Experiment 3.1 Corrected Report to Mr.R, and Experiment 4.1 and Experiment 4.2 informal reports in notebook Online Module Test: Due by 11-5 Module 5: Muscle Histology and Physiology Class discussions: Week of 11-3, Week of 11-10 For the first class meeting (Week of 11-3), you need to have read up to and including the section called "How a Muscle Fiber Contracts." For the second class meeting (Week of 11-10), you need to have finished reading Module 5. Experiment report to be turned in to Mr. Rosenoff: None Assignments Due: {27} Module Study Guide: Required Experiments: Online Module Test: Due by 11-12 Experiment 5.1 informal report in notebook Due by 11-19 Module 6: The Skeletal Muscle System Class discussions: Week of 11-17, Thanksgiving Break: 11/22 to 11/30, Week of 12-1 For the first class meeting (Week of 11-17), you need to have read up to and including the section called "Major Muscles of the Anterior Chest and Abdominal Wall." For the second class meeting (Week of 12-1), you need to have finished reading Module 6. Formal Experiment report to be turned in to Mr. Rosenoff: None Assignments Due: Module Study Guide: Required Experiments: Online Module Test: Due by 12-3 None Due by 12-10 Module 7: The he Nervous System: Neurons and Neuroglia Class discussions: Week of 12-8, Week of 12-15, Christmas Break: 12/20/2014 to 1/4/2015 For the first class meeting (12-8), you need to have read up to and including the section called "Nerve Structure." For the second class meeting (12-15), you need to have finished reading Module 7. Formal Experiment report to be turned in to Mr. Rosenoff: Experiment 7.1 Draft Report Assignments Due: Module Study Guide: Required Experiments: Online Module Test: Due by 12-17 Due by 1-7: Experiment 7.1 Draft Report to Mr.R Due by 1-7 Module 8: The Central Nervous System {28} Class discussions: Week of 1-5, Week of 1-12 For the first class meeting (Week of 1-5), you need to have read up to and including the section called "The Cerebrum in More Detail." For the second class meeting (Week of 1-12), you need to have finished reading Module 8. Formal Experiment report to be turned in to Mr. Rosenoff: Experiment 7.1 Corrected Report Assignments Due: Module Study Guide: Due 1-14 Experiment Reports: Due 1-21: Experiment 7.1 Corrected Report to Mr.R Semester Exam: Due 1-21 (Exam covers Modules 1 thru 8. There WILL be questions over Module 8 on the Exam.) Parent Notebook Report -- Due 01/23/2015 SECOND SEMESTER Module 9: The Peripheral Nervous System Class discussions: Week of 1-19, Week of 1-26 For the first class meeting (Week of 1-19), you need to have read up to and including the section called "The Sense of Smell." For the second class meeting (Week of 1-26), you need to have finished reading Module 9. Formal Experiment report to be turned in to Mr. Rosenoff: None Assignments Due: Module Study Guide: Required Experiments: notebook. Online Module Test: Due by 1-28 Due by 2-4: Experiment 9.1 and Experiment 9.2 informal reports in Due by 2-4 Module 10: The Endocrine System {29} Class discussions: Week of 2-2, Week of 2-9, Winter Break: 2/14 to 2/22 For the first class meeting (Week of 2-2), you need to have read up to and including the section called "Hormone Chemistry." For the second class meeting (Week of 2-9), you need to have finished reading Module 10. Formal Experiment report to be turned in to Mr. Rosenoff: None Assignments Due: Module Study Guide: Required Experiments: Online Module Test: Due by 2-11 None Due by 2-25 Module 11: The Circulatory System Class discussions: Week of 2-23, Week of 3-2 For the first class meeting (Week of 2-23), you need to have read up to and including the section called "Blood as a Connective Tissue." For the second class meeting (Week of 3-2), you need to have finished reading Module 11. Formal Experiment report to be turned in to Mr. Rosenoff: Experiment 11.3 Draft Report Assignments Due: Module Study Guide: Due by 3-4 Required Experiments: Due by 3-11: Experiment 11.1 and Experiment 11.2 in notebook and Experiment 11.3 Draft Report to Mr.R Online Module Test: Due by 3-11 Module 12: The Lymphatic System Class discussions: Week of 3-9, Week of 3-16 For the first class meeting (Week of 3-9), you need to have read up to and including the section called "The Spleen and Thymus Gland." {30} For the second class meeting (Week of 3-16), you need to have finished reading Module 12. Formal Experiment report to be turned in to Mr. Rosenoff: Experiment 11.3 Corrected Report Assignments Due: Module Study Guide: Due by 3-18 Required Experiments: Due by 3-25: Experiment 11.3 Corrected Report to Mr.R and Experiment 12.1 informal report in notebook Online Module Test: Due by 3-25 Module 13: The Digestive System Class discussions: Week of 3-23, Week of 3-30, Spring Break: 4/4 to 4/12 For the first class meeting (Week of 3-23), you need to have read up to and including the section called "The Stomach." For the second class meeting (Week of 3-30), you need to have finished reading Module 13. Formal Experiment report to be turned in to Mr. Rosenoff: None Assignments Due: Module Study Guide: Required Experiments: notebook Online Module Test: Due by 4-1 Due by 4-15: Experiment 13.1 and Experiment 13.2 informal reports in Due by 4-15 Module 14: The Respiratory System Class discussions: Week of 4-13, Week of 4-20 For the first class meeting (Week of 4-13), you need to have read up to and including the section called "The Muscles and Mechanics of Ventilation." For the second class meeting (Week of 4-20), you need to have finished reading Module 14. Formal Experiment report to be turned in to Mr. Rosenoff: Experiment 14.1 Draft Report {31} Assignments Due: Module Study Guide: Required Experiments: Online Module Test: Due by 4-22 Due by 4-29: Experiment 14.1 Draft Report to Mr.R Due by 4-29 Module 15: The Urinary System Class discussions: Week of 4-27, Week of 5-4 For the first class meeting (Week of 4-27), you need to have read up to and including the section called "Urine Formation, Step 2: Reabsorption." For the second class meeting (Week of 5-4), you need to have finished reading Module 15. Formal Experiment report to be turned in to Mr. Rosenoff: Experiment 14.1 Corrected Report Assignments Due: Module Study Guide: Due by 5-6 Required Experiments: Due by 5-13: Experiment 14.1 Corrected Report to Mr.R and Experiment 15.1 informal report in notebook Online Module Test: Due by 5-13 Parent Notebook Report -- Due 05/22/2015 Module 16: The Reproductive System Class discussions: Week of 5-11, Week of 5-18 For the first class meeting (Week of 5-11), you need to have read up to and including the section called "Hormonal Control of Male Reproduction." For the second class meeting (Week of 5-18), you need to have finished reading Module 16. Formal Experiment report to be turned in to Mr. Rosenoff: None Assignments Due: Module Study Guide: Due by 5-20 {32} Required Experiments: None Exam Review: During class week of 5-18 Final Assignments: Second Semester Exam: Due 5-27 (Exam covers Modules 9 thru 16. There WILL be questions over Module 16 on the Exam.) Please note that 5/27 is the LAST POSSIBLE DAY to turn in assignments for the school year. I will close my grade book at 6:01 PM, Eastern, and finalize grades. Please do not be late with your final assignments. To you, the parent, I promise that I will make every effort possible to keep in close contact with you; however, in order to do that, I need to be able to find you! Please keep the school and me advised of a daytime phone number where you can be reached, and provide me with an e-mail account to which only you have access. I do not make evening or weekend phone calls or answer or send e-mails on the weekends. (My family needs my time during these hours.) Therefore, it is imperative that I be able to contact you during daylight hours. If you have any questions or concerns, please feel free to contact me at 360-347-1799 during my school year office hours, which are 3:00 – 6:00 PM, Eastern Time, Monday, Wednesday, or Friday or e-mail me at rwt1@comcast.net. God Bless your efforts this year and always, Mr. Steven Rosenoff Advanced Biology Instructor Cleo’s Classroom Table of Contents Start {33} RED WAGON TUTORIALS Parent Agreement Thank you for your interest in this Cleo’s Classroom Advanced Biology class. I am excited about the new school year for two reasons: (1) our class will be live-feed Internet. Unlike some Internet courses which require you to send in assignments which I grade and then return, you and I will be communicating directly with each other on at least a weekly basis. This arrangement gives us greater opportunity to interact and learn from each other because we will be together for ninety minutes each week; (2) our curriculum will be challenging and exhilarating. Sixteen major topics will be covered during the course of this year. These units are all outlined in the book Human Body: Fearfully and Wonderfully Made!, 1st Edition, by Dr. Jay Wile and Marilyn F. Shannon, which will also be our classroom text. As a former medical and industrial research scientist, you can be certain I will bring a depth of knowledge to the topics we will study together. I am eager to share my experience with you in an educational capacity. In order to start out with a firm understanding of my expectations for this class, I would ask that you please review the following requirements with your student: 1. Students entering advanced biology should have completed Algebra I prior to the start of the academic school year. (Success in biology at this level and math ability go hand-in-hand, according to research.) 2. Incoming advanced biology students should have mastered the introductory concepts covered in a general biology, including basic laboratory procedures and experiment report writing. (Please see Exploring Creation with Biology, 2nd Edition by Dr. Jay Wile for guidance as to basic curriculum covered in these courses.) 3. Students should have a basic understanding of document citation and have the ability to produce a two-to-three page formal laboratory experiment report following a standardized documentation style I will provide. 4. Students or their parents should have basic computer literacy, including knowledge of how to download files, load web pages, open and create e-mail attachments in Word 2010 docx or Adobe PDF format, and how to copy from a Word 2010 docx or Adobe PDF document and paste to a website template. (These are not skills I teach in class.) 5. The text we will be using for our course, as stated earlier, is Human Body: Fearfully and Wonderfully Made!, 1st Edition, by Dr. Jay Wile and Marilyn F. Shannon. You are also {34} required to purchase the textbook Solutions Manual. The textbook and manual, or a complete CD-ROM version of the text/manual, and other support materials are available through Christian Book Distributors, http://www.christianbook.com/. The text is divided into 16 modules. Unless otherwise noted in the advanced biology course schedule, (1) a parent-graded module study guide; (2) a paper-and-ink informal report (following an informal format I will provide) for each required module experiment; and (3) an instructor-graded online module test MUST all be completed for each module. Each student will also produce a formal lab report each quarter following the formal report format that I will provide. There will also be an instructor-graded semester exam given at the end of 1 st and 2nd semesters. I will also require that the student maintain a penciled lab notebook of all lab experiment work completed: I will post a list of the required experiments to be completed for each semester. Remember: these assignments MUST BE COMPLETED BY THE DUE DATES LISTED in the course schedule, which I will post online. 6. Students must complete the module tests and the semester exams ONLINE on the Student Portal. Parents MUST post their parent notebook report on the Student Portal site also. Completing this assignment submission process provides the student/parent with a receipt for the assignment which is time stamped and gives me a computer-stored copy to look back on. There is a link for posting each one of these assignments available on the Student Portal site. Students will forward their formal experiment report as a Microsoft Word 2010 docx or Adobe PDF document. Please note: I require that you word process (using Word 2010 docx or Adobe PDF, Times New Roman, 12 font, 1” margins) and spell check the formal experiment report prior to its being sent as an e-mailed attachment. I will provide you with a Steps to Success handout (in your Assignment Supplement) which will detail the best method to accomplish all this assignment work. 7. Laboratory work is an important endeavor in your child’s overall grade and education and should be completed. A microscope and prepared slide set are required for this course. Please be sure to be diligent in completing ALL the required lab assignments indicated in the Course Schedule. Laboratory supplies for this course are obtained from common household and pantry items, hunting and gathering activities, buy purchasing a blood typing kit, and by purchasing a dissection kit and specimens through a commercial source specified in the Laboratory Equipment section at the front of Dr. Wile's text. I will require a parent notebook report be submitted each semester stating the total number of experiments completed per number required. This report will amount to one third of your student’s laboratory grade. Please do not be late. (Those of you living and working overseas may have special needs regarding completion of laboratory work. Please feel free to contact me on an individual basis so that I can help with any concerns you may have.) 8. Students should be disciplined enough to submit required work on time. As per stated policy, I will deduct 10% per day from the score received on the assignment on all late work (including the parent notebook report), unless the lateness results from personal illness, family emergency, or computer problem of a non-reoccurring nature. In these instances, I will grant full points. A schedule for the course, providing due dates for all assignments for the entire year, will be posted online before the start of the academic year. (If you are leaving on vacation or {35} some other personal-choice holiday, please adjust your study schedule to submit the assigned work before leaving. I will always accept an assignment early. I am available during my office hours to help you complete assignments before the due date, when and if necessary, during the school year.) All class assignments are due by 6:00 PM, Eastern Time, on the date indicated in the Schedule I will post online. (The Student Portal time stamp on your work is the final authority on whether something is submitted on time or not.) NOTE: 6:01 PM, Eastern Time, starts a new day, and I will subtract 10% if your work arrives at or after that time. 9. In order to begin class immediately, students are expected to be signed on to their computers at the class start time with materials ready. Technology is often a fickle thing. Many students have to log in several times to get a decent connection. Try to log into class five minutes early to avoid being late. (This also provides the student time to chat with classmates prior to the start of our session.) Those students who are habitually tardy for no valid reason will be locked out of the system until a parent conference can be scheduled. (Those of you living and working overseas may have special problems regarding absences and tardiness. Please feel free to contact me on an individual basis so that I can help with your needs.) 10. Students are expected to come to class prepared every day, which means all assigned reading, exercises, and labs have been completed. The following rules and procedures have been established to create an environment conducive to learning: a. b. c. d. Be Prepared -- have assignments finished prior to class. Be Prompt -- turn in all work on the date it is due. Be Respectful -- to yourself, other students, and your tutor. Be Involved -- daily participation is required. Those students who follow the rules stated above will receive positive reinforcement through the use of participation points. These points will be given at my discretion to students who are organized, complete work on time and to the best of their ability, and behave in an appropriate manner. 11. Daily participation in class is also required. Students are expected to have a working microphone for this purpose. Students are expected to ask questions, participate in discussions, and generate and share ideas. Often participation is the deciding factor when figuring grades (an ‘A’ vs. an ‘A-’ or perhaps a ‘D’ vs. an ‘F’). You need to do more than show up to class and complete your assignments to succeed -- you need to be an active participant in your education. (Please note: I cannot and will not, in good conscience, pass a student who does not participate in his or her education.) {36} 12. The following grade scale will be used for the course: A AB+ B B- 93 - 100% 90 - 92% 87 - 89% 83 - 86% 80 - 82% C+ C CD+ D 77 - 79% 73 - 76% 70 - 72% 67 - 69% 60 - 66% F 59% and below The two typewritten, formal laboratory write-ups (one required each quarter) and the parent notebook report detailing completion of all required experiment work comprise 25% of the student’s semester grade; seven module tests each semester make up an additional 50% of the student’s grade; the end-of-semester exam comprises 25% of the total score for each semester. A perpetual grade report for each semester for every student is available on the password protected course web site for viewing at any time during the school year. If you have further questions regarding course requirements, my e-mail address is rwt1@comcast.net. Please feel free to contact me on Monday, Wednesday, or Friday afternoons between 3:00 PM – 6:00 PM, Eastern Time. My phone number is 360-347-1799. Looking forward to seeing you in September! God Bless, Steve Rosenoff Advanced Biology Instructor Cleo’s Classroom Table of Contents Start {37} Module 1 Lesson 1: Reading Assignment: ECHB, pp. 1 - 14 Lesson Video: HModule01-1 Lesson Starts: 18:45 An Organizational Overview and Some Review, Part 1 Please watch this video before class starts or the session video is viewed: http://www.youtube.com/watch?v=y2N_b0qwvxY#t=40 (Parents: Please be advised that these are You-Tube videos. We have no control over the ads that are presented. We do our best to screen the presentations, but ads change daily. Please preview the video environment before your student views the links. We feel that Google Chrome is the best browser for students to watch videos. It screens content very well.) https://www.google.com/chrome/browser/ Today’s class has two parts. The first part is new introductory material beyond your basic biology course. The second part is review material, which you should know regarding the topic of cell structure. I will go over the first part (A) during class. If there is time, I will go over the second part (B). Both parts (A and B) are testable. A. Lecture: 1. The human body is God’s ultimate what? _______________ _______________ 2. The human body is the most incredible _______________ manufacturing plant in the world. 3. T or F: Physiology underlies anatomy. ________ 4. The study of the macroscopic structures of an organism is which of the following? a. gross anatomy b. structural anatomy {38} c. cellular anatomy d. idon’tknow anatomy 5. Gross anatomy can be divided into what two divisions? _______________ _______________ and _______________ _______________ 6. While human anatomy deals with human body design, comparative anatomy deals with the _______________ and _______________ in structure between creatures. 7. T or F: A physician finding swollen glands in a person’s neck is an example of surface anatomy. ________ 8. A podiatrist (foot doctor) specializes in what kind of anatomy? a. b. c. d. comparative surface regional systemic 9. Systemic anatomy means anatomy by what? _______________ _______________ 10. _______________ is the science that studies the functions of an organism and its parts. 11. T or F: Muscles are the building blocks of the body. ________ 12. The human organism is made up of how many organ systems? a. b. c. d. 5 7 9 11 13. A group of tissues specialized for a particular function is termed what? _____ _______________ 14. Tissues are groups of ________ specialized for a particular function. 15. T or F: There are only four kinds of human tissues. ________ 16. Ligaments attach bone to bone at the joints. Ligaments are made up of what kind of tissue? a. b. c. d. nervous muscular connective epithelial {39} 17. Members of kingdom Animalia have what kind of cells? _______________ 18. To be considered eukaryotic, the cell must have membrane-bound _______________. 19. T or F: Proteins, salts, fats, acids, etc, are characteristic of the molecular level of human body organization. ________ 20. How many basic functions must a cell perform to be alive? a. b. c. d. 5 7 9 11 21. Your parathyroid glands produce a hormone called PTH, which regulates calcium levels in your blood. When your calcium levels are low, the parathyroid cells produce PTH and put it into your bloodstream. This encourages bone-destroying cells to dissolve bone tissue, which increases your blood calcium level. 22. A cell takes in a polysaccharide, breaks it down, and burns it for energy. What 4 functions (excluding homeostasis) did it perform? 23. When that cell is done, it must eliminate the water and carbon dioxide produced. Both are soluble in cell fluids. What 2 functions (excluding homeostasis) are performed? 24. When you scratch an itch, you destroy roughly 100 skin cells or so. What function (excluding homeostasis) must skin cells be constantly performing so that this doesn’t hurt you? 25. A cell takes in a substance and breaks it down. It needs to get rid of part of that substance which is not soluble in the cell fluids. What 4 functions (excluding homeostasis) are used? 26. _______________ is a state of equilibrium in the body with respect to its functions, chemical levels, and tissues. 27. T or F: Maintaining environmental “set points” within a normal range creates homeostasis within the human body. ________ 28. Which of the following environmental variables have set points with the human body? a. b. c. d. e. blood pressure oxygen concentration body temperature blood pH All the above have set point norms. {40} 29. Something in the environment that causes one or more variables to move too far from their set point is termed what? _______________ 30. The increased muscle activity associated with shivering counteracts the stress of being too _______________. 31. T or F: Stress is an imbalance that must be corrected for proper health. ________ 32. Of the eleven organ systems in the human body, which of the following may actually increase stress or simply not counteract it? a. b. c. d. the reproductive system the nervous system the digestive system the lymphatic system 33. What two body systems are responsible for the control of homeostasis? _______________ system and _______________ system 34. The _______________ system senses variables that go too far beyond set point norms, and the _______________ system secretes hormones that help restore homeostasis. 35. T or F: A receptor is a structure in the body that can change the value of a set point variable. ________ 36. Negative feedback systems are healthy because they promote which of the following? a. b. c. d. e. absorption biosynthesis digestion egestion homeostasis 37. Positive feedback systems can lead to what if uncontrolled? _______________ B. Cell Structure Review: (These are sample questions I would expect you to be able to answer regarding this topic for your test.) 1. Cytology is the study of _______________. 2. When the distance across the cell doubles, the cell’s volume goes up by a factor of what? ________ 3. T or F: Aside from the nucleus and centrioles, there are often SEVERAL of each organelle found in a given cell. ________ {41} 4. The plasma membrane is which of the following? a. b. c. d. semi-permeable found only in animal cells solid like an egg composed of a phosphoprotein bilayer 5. _______________ is a jelly-like fluid in which all of the cell organelles are suspended. 6. What bean-shaped organelles are often referred to as the “powerhouses” of the cell? _______________ 7. T or F: Hydrolysis reactions take place in the hydrosome. ________ 8. Found in both eukaryotic and prokaryotic cells, ribosomes are non-membrane bound organelles that are responsible for production of what in the cell? a. b. c. d. fats carbohydrates proteins none of the above 9. There are two types of endoplasmic reticulum: _______________ ER and _______________ ER. 10. When a protein or lipid is needed by the cell, what organelles package the protein or lipid molecule so that it can be transported to the place in the cell where needed? ______________ _______________ 11. T or F: Vacuoles are “sacs” that exist in the cell. ________ 12. Centrioles have which of the following functions? a. b. c. d. form the base of the flagella pull apart the duplicated chromosomes during mitosis pull apart the duplicated chromosomes during meiosis All the above are correct. 13. The nucleus contains what, which is essential for cell life? _______________ 14. The cytoskeleton is made up of three basic kinds of fibers: _______________, _______________, and _______________. 15. T or F: Microfilaments are responsible for the ponderous motion exhibited by muscle cells. ________ {42} 16. Microtubules perform which of the following for the cell? a. b. c. d. participate in cell movement. produce channels in which materials can flow form the tube-foot of the starfish provide for transport across the plasma membrane 17. The intermediate filaments are mostly responsible for strengthening and supporting the cell, which allows it to keep its _______________. Table of Contents Start {43} Answers & Links: Lesson 1: An Organizational Overview and Some Review, Part 1 http://redwagontutorials.com/AD/HandoutsH/Module01/1stOverhead01.htm http://redwagontutorials.com/AD/HandoutsH/Module01/2ndOverhead.htm http://redwagontutorials.com/AD/HandoutsH/Module01/3rdOverhead.htm http://www.redwagontutorials.com/php/ http://redwagontutorials.com/AD/HandoutsH/Module01/HModule1SG.htm http://redwagontutorials.com/AD/HandoutsH/Module01/SampleInformalReport.htm http://redwagontutorials.com/AD/HandoutsH/Module01/FormalReport2a.htm Please watch this video before class starts or the session video is viewed: http://www.youtube.com/watch?v=y2N_b0qwvxY#t=40 (Parents: Please be advised that these are You-Tube videos. We have no control over the ads that are presented. We do our best to screen the presentations, but ads change daily. Please preview the video environment before your student views the links. We feel that Google Chrome is the best browser for students to watch videos. It screens content very well.) https://www.google.com/chrome/browser/ Today’s class has two parts. The first part is new introductory material beyond your basic biology course. The second part is review material which you should know regarding the topic of cell structure. I will go over the first part (A) during class. If there is time, I will go over the second part (B). Both parts (A and B) are testable. A. Lecture: 1. The human body is God’s ultimate what? _______________ _______________ Answer: The human body is God’s ultimate design achievement. {44} http://www.artwallpapers.net/celebs/michael_jordan/01/michael_jordan01.jpg 2. The human body is the most incredible _______________ manufacturing plant in the world. Answer: The human body is the most incredible chemical manufacturing plant in the world. http://en.wikipedia.org/wiki/Chemical_makeup_of_the_human_body 3. T or F: Physiology underlies anatomy. ________ Answer: False. Anatomy underlies physiology. http://www.nlm.nih.gov/medlineplus/anatomy.html http://en.wikipedia.org/wiki/Human_physiology 4. The study of the macroscopic structures of an organism is which of the following? a. b. c. d. gross anatomy structural anatomy cellular anatomy idon’tknow anatomy Answer: The correct answer is (a). Gross anatomy is the study of the macroscopic structures of an organism: the heart, the lungs, the brain, the fingers, etc., are all things that can be seen without a microscope. Microscopic anatomy is the study of the microscopic structures of an organism: the heart’s cardiac muscle cells, the lung’s alveoli, the brain’s neurons, and the finger’s epithelial cells would be examples. http://www.news.wisc.edu/story_images/0000/0269/anatomy_lab_skeleton07_1501.jpg http://www.histology-world.com/ 5. Gross anatomy can be divided into what two divisions? _______________ _______________ and _______________ _______________ Answer: Gross anatomy can be divided into human anatomy and comparative anatomy. 6. While human anatomy deals with human body design, comparative anatomy deals with the _______________ and _______________ in structure between creatures. http://en.wikipedia.org/wiki/Comparative_anatomy Answer: While human anatomy deals with human body design, comparative anatomy deals with the similarities and differences in structure between creatures. The bones of a bird’s wing resemble a human radius and ulna, while the bones in a bat’s wing resemble human fingers. {45} Convergent evolution says that wings on reptiles, insects, birds, and bats all developed along different evolutionary lines and there is no common ancestor for these. It is hard enough to account for wings developing once by random chance, let alone several times along different lineages. The chance of a 20-link chain having four different links assembling itself exactly the same way by random chance is 1.2 trillion to 1. DNA for wings is billions of linkages long. You can’t calculate a number big enough to account for wing DNA happening more than once, let alone four times along different species. The math for wing evolution just does not add up. http://www.innerbody.com/ http://legacy.owensboro.kctcs.edu/gcaplan/bio/Notes/Image689.gif 7. T or F: A physician finding swollen glands in a person’s neck is an example of surface anatomy. ________ Answer: True. A physician finding swollen glands in a person’s neck is an example of surface anatomy. Often called “anatomy by Braille,” surface anatomy is feeling for abnormal changes to the person’s anatomy. http://en.wikipedia.org/wiki/Surface_anatomy 8. A podiatrist (foot doctor) specializes in what kind of anatomy? a. b. c. d. comparative surface regional systemic Answer: The correct answer is (c). A podiatrist (foot doctor) specializes in the regional anatomy of the human foot. http://en.wikipedia.org/wiki/Podiatry 9. Systemic anatomy means anatomy by what? _______________ _______________ Answer: Systemic anatomy means anatomy by organ systems: digestive, nervous, circulatory, etc. It deals with how organs of the body work together to perform a function. http://www.cprnation.org/assets/pages/78/The_heart_as_a_double_pump.jpg 10. _______________ is the science that studies the functions of an organism and its parts. Answer: Physiology is the science that studies the functions of an organism and its parts. http://hungeree.com/wp-content/uploads/2012/08/pb-120807-alexandra-raisman-gold-nj-01.jpg {46} 11. T or F: Muscles are the building blocks of the body. ________ Answer: False. Tissues are the building blocks of the body. Histology is the study of tissues; therefore, a histologist studies the building materials of the body. http://madhyantikaaherbals.synthasite.com/resources/human%20body%20%20tissues.jpg 12. The human organism is made up of how many organ systems? a. b. c. d. 5 7 9 11 Answer: The correct answer is (d). The human organism is made up of eleven organ systems. http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.1.htm 13. A group of tissues specialized for a particular function is termed what? _____ _______________ Answer: An organ is a group of tissues specialized for a particular function. http://en.wikipedia.org/wiki/Organ_(anatomy) 14. Tissues are groups of ________ specialized for a particular function. Answer: Tissues are groups of cells specialized for a particular function. http://en.wikipedia.org/wiki/Tissue_(biology) 15. T or F: There are only four kinds of human tissues. ________ Answer: True. There are only four kinds of human tissues: nervous, muscular, connective, and epithelial. 16. Ligaments attach bone to bone at the joints. Ligaments are made up of what kind of tissue? a. b. c. d. nervous muscular connective epithelial Answer: The correct answer is (c). Ligaments attach bone to bone at the joints. Ligaments are made up of connective of tissue. {47} http://www.osteoarthritisblog.com/wp-content/uploads/2011/04/knee-ligaments.png 17. Members of kingdom Animalia have what kind of cells? _______________ Answer: Members of kingdom Animalia have eukaryotic cells. http://cellsalive.com/cells/cell_model.htm Remember, there are five kingdoms in all of Creation: Monera, Protista, Fungi, Plantae, and Animalia. Each kingdom has its defining characteristic: 1. Monera: prokaryotic cells; bacterial cell type; microscopic; producers, decomposers, or parasitic. 2. Protista: eukaryotic cells; animal cell type; mostly microscopic or some macroscopic; no specialized tissues; form aggregates; producers, consumers, or decomposers. 3. Fungi: eukaryotic cells; animal cell type; microscopic or macroscopic; has specialized tissues; generally multicellular; decomposer or parasitic. 4. Plantae: eukaryotic cells; plant cell type; microscopic or macroscopic; has specialized tissues; generally multicellular; producer. 5. Animalia: eukaryotic cells; animal cell type; microscopic or macroscopic; has specialized tissues; generally multicellular; consumers, generally herbivores, carnivores or omnivores. 18. To be considered eukaryotic, the cell must have membrane-bound _______________. Answer: To be considered eukaryotic, the cell must have membrane-bound organelles. http://micro.magnet.fsu.edu/cells/animalcell.html 19. T or F: Proteins, salts, fats, acids, etc, are characteristic of the molecular level of human body organization. ________ Answer: True. Proteins, salts, fats, acids, etc, are characteristic of the molecular level of human body organization. The seven levels of human body organization, therefore, are organism, organ system, organs, tissues, cells, organelles, and molecules. Note: Molecules can be further broken down into atoms, but the unique property of the molecule is lost in the process. (Organic changes into inorganic.) http://en.wikipedia.org/wiki/Protein#Structure_of_proteins 20. How many basic functions must a cell perform to be alive? a. b. c. d. 5 7 9 11 {48} Answer: The correct answer is (d). There are eleven basic functions that a cell must perform to be alive: http://www.biology4kids.com/files/cell2_main.html Absorption, biosynthesis, digestion, egestion, excretion, homeostasis, irritability, movement, respiration, reproduction, and secretion. Abdee him rrs 21. Your parathyroid glands produce a hormone called PTH, which regulates calcium levels in your blood. When your calcium levels are low, the parathyroid cells produce PTH and put it into your bloodstream. This encourages bone-destroying cells to dissolve bone tissue, which increases your blood calcium level. http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/thyroid/anatomy.html a. What 3 functions (excluding homeostasis) do the parathyroid gland cells perform to make this happen? Answer: They must make PTH, which is BIOSYNTHESIS. They must move it to the plasma membrane, which is MOVEMENT. They must expel it. Since the chemical is being used by other cells, this is SECRETION. b. What is the first function (excluding homeostasis) that the bone-destroying cells perform in this situation? Answer: They must respond to the PTH. That is IRRITABILITY. 22. A cell takes in a polysaccharide, breaks it down, and burns it for energy. What 4 functions (excluding homeostasis) did it perform? http://en.wikipedia.org/wiki/File:CellRespiration.svg Answer: The cell takes in the polysaccharide. That is ABSORPTION. The cell moves it to where it can be broken down. That is MOVEMENT. The cell breaks it down. That is DIGESTION. The cell converts it to energy. That is RESPIRATION. 23. When that cell is done, it must eliminate the water and carbon dioxide produced. Both are soluble in cell fluids. What 2 functions (excluding homeostasis) are performed? Answer: It must move them to the plasma membrane. That is MOVEMENT. It must expel them. Since they are soluble, that is EXCRETION. 24. When you scratch an itch, you destroy roughly 100 skin cells or so. What function (excluding homeostasis) must skin cells be constantly performing so that this doesn’t hurt you? {49} Answer: The skin cells must be constantly making new ones to replace those which you destroy. That is REPRODUCTION. http://www.cellsalive.com/mitosis.htm 25. A cell takes in a substance and breaks it down. It needs to get rid of part of that substance which is not soluble in the cell fluids. What 4 functions (excluding homeostasis) are used? Answer: The cell takes it in. That is ABSORPTION. The cell must move it to where it can be broken down. That is MOVEMENT. The cell must break it down. That is DIGESTION. The cell must move the non-soluble part back to the membrane. We already mentioned that. The cell must get rid of the non-soluble part. Since it is non-soluble, that is EGESTION. 26. _______________ is a state of equilibrium in the body with respect to its functions, chemical levels, and tissues. http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookANIMORGSYS.html Answer: Homeostasis is a state of equilibrium in the body with respect to its functions, chemical levels, and tissues. It is the process of maintaining the status quo in the cell. Homeostasis will employ the 10 other basic functions in order to maintain the status quo. 27. T or F: Maintaining environmental “set points” within a normal range creates homeostasis within the human body. ________ Answer: True. Maintaining environmental “set points” within a normal range creates homeostasis within the human body. 28. Which of the following environmental variables have set points with the human body? a. b. c. d. e. blood pressure oxygen concentration body temperature blood pH All the above have set point norms. Answer: The correct answer is (e). Blood pressure, oxygen concentration, body temperature, and blood pH, as well as thousands of other variables, all have set point norms. http://www.thebody.com/content/art6062.html#normal 29. Something in the environment that causes one or more variables to move too far from their set point is termed what? _______________ Answer: Stress is something in the environment that causes one or more variables to move too far from their set point. {50} 30. The increased muscle activity associated with shivering counteracts the stress of being too _______________. Answer: The increased muscle activity associated with shivering counteracts the stress of being too cold. http://www.whoateallthepies.tv/wp-content/gallery/snow/pa-1020612.jpg 31. T or F: Stress is an imbalance that must be corrected for proper health. ________ Answer: True. Stress is an imbalance that must be corrected for proper health. 32. Of the eleven organ systems in the human body, which of the following may actually increase stress or simply not counteract it? a. b. c. d. the reproductive system the nervous system the digestive system the lymphatic system Answer: The correct answer is (a). Of the eleven organ systems in the human body, the reproductive system may actually increase stress or simply not counteract it. 33. What two body systems are responsible for the control of homeostasis? _______________ system and _______________ system Answer: The nervous system and the endocrine system are responsible for the control of homeostasis. http://en.wikipedia.org/wiki/File:TE-Nervous_system_diagram.svg http://en.wikipedia.org/wiki/Endocrine_system 34. The _______________ system senses variables that go too far beyond set point norms, and the _______________ system secretes hormones that help restore homeostasis. Answer: The nervous system senses variables that go too far beyond set point norms, and the endocrine system secretes hormones that help restore homeostasis. 35. T or F: A receptor is a structure in the body that can change the value of a set point variable. ________ Answer: False. An effector is a structure in the body that can change the value of a set point variable. {51} Receptors monitor the value of the body’s variables. A control center establishes the normal range for the variable. When the control center (usually the brain) receives input from the receptors that a variable may go outside its normal range, the control center sends a message (either electrical or hormonal) to one or more effectors to adjust the variable’s value. 36. Negative feedback systems are healthy because they promote which of the following? a. b. c. d. e. absorption biosynthesis digestion egestion homeostasis Answer: The correct answer is (e). Negative feedback systems are healthy because they promote homeostasis. (Examples: Blood pressure regulation and blood sugar level control are both examples of negative feedback systems.) http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.2.htm 37. Positive feedback systems can lead to what if uncontrolled? _______________ Answer: Positive feedback systems can lead to death if uncontrolled. (Example: Lower blood pressure generates even lower blood pressure in a positive feedback system. Negative feedback systems are inversely relational to the variable’s change; low blood pressure causes the release of substances which increase the blood pressure variable.) http://www.getbodysmart.com/ B. Cell Structure Review: (These are sample questions I would expect you to be able to answer regarding this topic for your test.) 1. Cytology is the study of _______________. Answer: Cytology is the study of cells. Since the 1600’s, scientists have been studying cells. In the entire history of cytology, scientists have only seen cells produced in one way: from other cells. Never have chemicals or any other non-living substances produced cells. In fact, scientists cannot even produce cells in the lab unless they have a living cell to start with. Even the process of cloning starts with a living cell. Without that living cell, cloning would not work. http://137.189.150.85/cytopathology/GT1photo/4/08153022.JPG 2. When the distance across the cell doubles, the cell’s volume goes up by a factor of what? ________ {52} Answer: When the distance across the cell doubles, the cell’s volume goes up by a factor of eight! Well, when a cell’s volume increases, it must absorb more nutrients to survive. The amount of nutrients it must absorb is actually dependent on its volume. Thus, when a cell’s radius doubles, its absorption must increase by a factor of 8. Since the amount of absorption that a cell needs is so dramatically dependent on the cell’s size, there is a fundamental size limit that cells can reach. After that point, they cannot grow any larger. That’s why cells are so small. 3. T or F: Aside from the nucleus and centrioles, there are often SEVERAL of each organelle found in a given cell. ________ http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.3.htm Answer: True. This is an idealized drawing of a cell. It is WAY TOO SIMPLE. First, the cell is three-dimensional, as are the organelles. This 2-dimensional drawing just makes the discussion simpler. Second, aside from the nucleus and centrioles, there are often SEVERAL of each organelle, depending on the cell itself. Just realize, then, that this is a VERY SIMPLIFIED drawing. http://search.aol.com/aol/image?query=Cell%20SEM%20picture 4. The plasma membrane is which of the following? a. b. c. d. semi-permeable found only in animal cells solid like an egg composed of a phosphoprotein bilayer http://micro.magnet.fsu.edu/cells/plasmamembrane/plasmamembrane.html Answer: The correct answer is (a). The plasma membrane is semi-permeable. It allows certain substances (nutrients, water, and oxygen, for example) to pass through and enter the cell, but it does not allow other substances (certain toxins, for example) in. Likewise, the plasma membrane allows water and waste products to leave the cell, but it does not allow the contents of the cell itself to leave. 5. _______________ is a jelly-like fluid in which all of the cell organelles are suspended. http://micro.magnet.fsu.edu/cells/animalcell.html Answer: Cytoplasm is a jelly-like fluid in which all of the cell organelles are suspended. The cytoplasm is comprised of a mixture of several different compounds, including proteins, fats, and carbohydrates. In addition, there are substances called ions in the cytoplasm. As you already learned in prior science classes, atoms must have the same number of protons and electrons in order to remain electrically balanced. Well, if an atom loses or gains an electron, it suddenly is thrown out of electrical balance. If an atom gains electrons (which are {53} negatively charged), it ends up with an overall negative charge. If an atom loses electrons, it ends up with an overall positive charge. Atoms that have gained or lost an electron are called ions. Since ions have electrical charge, they respond to electrical stimuli. 6. What bean-shaped organelles are often referred to as the “powerhouses” of the cell? _______________ http://micro.magnet.fsu.edu/cells/mitochondria/mitochondria.html Answer: Perhaps the most important of the organelles are the mitochondria, which is the plural of mitochondrion. These bean-shaped organelles are often referred to as the “powerhouses” of the cell because they are responsible for the respiration of monosaccharides, which releases energy that can be used by the cell. The mitochondria also possess DNA. Mitochondrial DNA codes for the production of certain proteins necessary for the mitochondrion to do its job. A mitochondrion cannot produce all of the proteins that it needs. The mitochondrion must rely on the DNA in the nucleus to produce those proteins it cannot make. 7. T or F: Hydrolysis reactions take place in the hydrosome. ________ http://micro.magnet.fsu.edu/cells/lysosomes/lysosomes.html Answer: False. All of the necessary hydrolysis reactions take place in the lysosome. Remember, in order to use polysaccharides or disaccharides, a cell must first break them down into monosaccharides using hydrolysis reactions. In addition, cells must break certain proteins and lipids down into their constituent parts (amino acids and fatty acids, respectively) in order to use them for biosynthesis. Interestingly enough, when the lysosome was first discovered, it was called the “suicide sac” because, prior to the death of certain cells, the lysosomes would release chemicals that destroyed the cell. Later on, scientists realized that as the cell dies, the membrane which encloses the lysosome is generally the first thing to deteriorate. When that membrane deteriorates, the contents of the lysosome spill into the cytoplasm of the cell. Some cells, such as white blood cells, actually use their lysosomes to commit suicide. A white blood cell tries to kill invading pathogens. One way it can do that is to fill itself with a huge amount of antibodies. Then, it can enter into a group of pathogens and rupture its own lysosomes. This will cause the cell to break open, and the antibiotic will spill out onto the pathogens, killing them. Thus, the white blood cell runs a “suicide mission” to destroy the pathogens. When you have an infected cut, the pus is actually the remains of the white blood cells after their suicide runs! 8. Found in both eukaryotic and prokaryotic cells, ribosomes are non-membrane bound organelles that are responsible for production of what in the cell? {54} a. b. c. d. fats carbohydrates proteins none of the above http://micro.magnet.fsu.edu/cells/ribosomes/ribosomes.html Answer: The correct answer is (c). The ribosomes are non-membrane bound organelles that are found in both eukaryotic and prokaryotic cells. These organelles are responsible for production of proteins in the cell. 9. There are two types of endoplasmic reticulum, _______________ ER and _______________ ER: http://micro.magnet.fsu.edu/cells/endoplasmicreticulum/endoplasmicreticulum.html Answer: The endoplasmic reticulum, commonly abbreviated as ER, is composed of an extensive network of folded membranes. There are two types of ER: rough ER and smooth ER. Rough ER is dotted with ribosomes; smooth ER is not. Since it has ribosomes, rough ER is a part of protein synthesis. Typically, specialized proteins that are secreted by certain cells are produced here. Although no protein synthesis occurs in smooth ER, many cells produce lipids in this organelle. These lipids are generally the means by which excess energy is stored. In addition, smooth ER inactivates certain harmful by-products of digestion and respiration and then sends them to the plasma membrane to be ejected. 10. When a protein or lipid is needed by the cell, what organelles package the protein or lipid molecule so that it can be transported to the place in the cell where it is needed? _______________ _______________ http://micro.magnet.fsu.edu/cells/golgi/golgiapparatus.html Answer: When a protein or lipid is needed by the cell, the Golgi bodies package the molecule so that it can be transported to the place in the cell where it is needed. Golgi bodies are comprised of flattened, interconnected membrane sacs that store proteins and lipids. When the cell produces proteins and lipids, they are transferred to the Golgi bodies where they are sorted and stored until needed. The “packaging” that goes on in the Golgi bodies is typically some process of adding a small molecule to the protein or lipid that is being processed. This chemical then can be used by the cell as a marker, telling the cell where to transport the molecule. Thus, the Golgi bodies function much like a mailing service. They take in molecules, package and address them, and then send them to where they are needed. 11. T or F: Vacuoles are “sacs” that exist in the cell. ________ http://micro.magnet.fsu.edu/cells/endosomes/endosomes.html {55} Answer: True. Vacuoles are “sacs” that exist in the cell. In addition to food vacuoles and contractile vacuoles, there are waste vacuoles that hold waste and phagocytic vacuoles that can be used to engulf things. If a vacuole is small, it can be called a VESICLE. A pinocytic vesicle is one that is formed so that proteins can be absorbed. A secretion vesicle is used to take chemicals made by the cell and send them out of the cell for other cells to use (secretion). 12. Centrioles have which of the following functions? a. b. c. d. form the base of the flagella pull apart the duplicated chromosomes during mitosis pull apart the duplicated chromosomes during meiosis All the above are correct. http://micro.magnet.fsu.edu/cells/centrioles/centrioles.html Answer: The correct answer is (d). In cells that possess flagella (euglena, for example) or cilia (paramecia, for example), the centriole actually form the base of the movement organelle. In many eukaryotic cells, centrioles appear in pairs. Each individual centriole is oriented at a 90 degree angle to its partner, like the corner of a square. These centrioles are necessary for reproduction, as they pull apart the duplicated chromosomes during mitosis and meiosis. 13. The nucleus contains what, which is essential for cell life? _______________ http://micro.magnet.fsu.edu/cells/nucleus/nucleus.html Answer: The nucleus contains the DNA, which is a basic criterion for life. During most of the cell’s life, the DNA is referred to as CHROMATIN. During the reproduction of the cell, the DNA winds itself up into chromosomes. The nucleus has its own membrane to keep certain chemicals out and let other chemicals in. In addition, there is a nucleolus that holds RNA. 14. The cytoskeleton is made up of three basic kinds of fibers: _______________, _______________, and _______________. Answer: Cytoskeleton is a network of fibers that holds the cell together, helps the cell to keep its shape, and aids in movement. The cytoskeleton is made up of three basic kinds of fibers: microfilaments, intermediate filaments, and microtubules. You already learned about microtubules when we discussed the centrioles, but the other two types of filaments are new to you. Microfilaments are fine, threadlike proteins found in the cell's cytoskeleton. Intermediate filaments are threadlike proteins in the cell's cytoskeleton that are roughly twice as thick as microfilaments 15. T or F: Microfilaments are responsible for the ponderous motion exhibited by muscle cells. ________ {56} http://micro.magnet.fsu.edu/cells/microfilaments/microfilaments.html Answer: True. The microfilaments are mostly associated with movement. For example, microfilaments are responsible for the ponderous motion exhibited by amoeba. They also can cause certain cells to contract. Muscle cells, for example, do their job by contracting and relaxing. The microfilaments in the muscle cells take care of this function. Finally, in some cells, the microfilaments also generate cytoplasmic streaming. http://micro.magnet.fsu.edu/cells/microtubules/microtubules.html 16. Microtubules perform which of the following for the cell? a. b. c. d. participate in cell movement produce channels in which materials can flow form the tube-foot of the starfish provide for transport across the plasma membrane Answer: The correct answer is (a). Microtubules are used to form cilia and flagella in the cells that have those structures. They also provide a “track” upon which organelles and vesicles can travel as they move throughout the cell. http://micro.magnet.fsu.edu/cells/intermediatefilaments/intermediatefilaments.html 17. The intermediate filaments are mostly responsible for strengthening and supporting the cell, which allows it to keep its _______________. Answer: The intermediate filaments are mostly responsible for strengthening and supporting the cell, which allows it to keep its shape. Another important role of the cytoskeleton is to keep the various organelles of the cell in their proper positions. Cellular organelles are not free to “float around” the cell because the internal cellular structure is just too complex to allow for that. Thus, the cytoskeleton holds this complex structure together by keeping each organelle in its proper position. Important!!!! The make-up of an individual cell's cytoskeleton is characteristic of the task for which the cell has been designed. For example, skin cells must be very rigid. As a result, the cytoskeleton of a skin cell contains a lot of intermediate filaments so that it can hold its shape well. A muscle cell does a lot of contracting and relaxing, so it has a lot of microfilaments in its cytoskeleton. A paramecium needs lots of cilia, so it has a high concentration of microtubules. Although you might not think about it, there are cells in your body that have cilia as well. The bronchial tubes that bring air to your lungs are lined with cells that have cilia. These cilia filter dust and debris from the air that you breathe and then beat back and forth to sweep the dust and debris away from your lungs. Table of Contents Start {57} Lesson 2: Reading Assignment: ECHB, pp. 14 - 27 Lesson Video: HModule01-2 Lesson Starts: 31:20 An Organizational Overview and Some Review, Part 2 Please watch this video before class starts or the session video is viewed: http://www.youtube.com/watch?v=S7CJ7xZOjm0 Today’s class has two parts. The first part is new materials beyond your basic biology course. The second part is review material which you should know regarding the topics of protein synthesis and cellular reproduction. I will go over the first part (A) during class. If there is time, I will go over the second part (B). Both parts (A and B) are testable. A. Lecture: 1. T or F: A beautiful example of structure and function can be seen in the cell’s plasma membrane. ________ 2. The plasma membrane is important to the life of the cell because it limits what goes ________ and ________ of the cell. 3. Three kinds of molecules found in the plasma membrane include _______________, _______________, and _______________. 4. A phospholipid is which of the following? a. b. c. d. a fat molecule with one fatty acid replaced by a phosphate group polar on one side and non-polar on the other “hydrophilic” on one end and “hydrophobic” on the other All the above are correct. 5. T or F: Phospholipids will re-orient themselves so that the polar heads of the phospholipid bilayer are pointed into the cell and out into the watery environment. ________ {58} 6. Like icebergs in the sea, what can be found floating in the phospholipid bilayer? _______________ 7. The three kinds of protein found in the phospholipid bilayer are _______________ _______________, _______________, and _______________ _______________. 8. Which kind of phospholipid bilayer protein acts as a marker, allowing cells to recognize each other? a. b. c. d. glycoproteins channel proteins receptor proteins phosphoproteins 9. T or F: Nerve cells release chemicals which bind with channel proteins on a muscle cell, causing the muscle to contract. ________ 10. _______________ stabilizes the cell membrane and gives the plasma membrane the right amount of firmness. 11. The words “fluid” and “mosaic” found in the fluid mosaic model description refer to what, respectively? fluid = _______________ ____________ and mosaic = _______________ 12. Which of the following define(s) a function of the plasma membrane? a. b. c. d. It delimits the cell. It provides receptors. It allows for defective permeability. All the above are membrane functions. 13. T or F: In Type I diabetes, the person does not make insulin. In Type II diabetes, the glucose receptors don’t respond to the glucose present. ________ 14. The ability of the plasma membrane to let certain materials in or out of the cell while restricting others is termed _______________ _______________. 15. The first reason plasma membranes are selectively permeable is due to the fact that polar substances dissolve _______________ and nonpolar substances dissolve _______________. 16. Water molecules move in and out through channel proteins because they are which of the following? a. b. c. d. polar in nature the right size have the correct charge all the above {59} 17. T or F: The amino acids in the channel proteins are oriented so that they form positive or negative charges in the channel, which repel like charges and attract opposite charges. ________ 18. In _______________ _______________, a carrier protein is designed for a specificallyshaped molecule. 19. What three conditions must be considered for mediated transport to work well? _______________, _______________, and _______________ 20. When similarly-shaped molecules fight to use the same carrier protein, which mediated transport condition is exhibited? _______________ 21. Which of the following is not a factor leading to the selective permeability of the plasma membrane? a. b. c. d. the membrane’s polar nature the presence of small molecule channel proteins the channel protein’s overall electrical charge the transport rate of large molecules through the plasma membrane 22. Molecules can enter the cell through one of four pathways: (1) dissolving through the phospholipid bilayer; (2) entering through channel proteins due to their small size; (3) entering through charged channel proteins due to their charge size;or (4) employing carrier proteins. Indicate which method (1, 2, 3, or 4) is being used by the following molecules. a. b. c. d. fructose ________ fluoride ions ________ lipids ________ water ________ 23. T or F: The four pathways above use two basic kinds of plasma membrane transport: passive transport and active transport. ________ 24. Passive transport is accomplished by what two processes? _______________ and _______________ _______________. 25. Diffusion is the movement of ions or molecules from an area of ____________ concentration to an area of ____________ concentration. 26. Diffusion using mediated transport is termed which of the following? a. b. c. d. mediated diffusion diffusion transport facilitated diffusion a weird and strange event {60} 27. T or F: Both diffusion and facilitated diffusion require energy (derived from the breakdown of ATP) to be expended by the cell. ________ 28. Active transport is movement against the dictates of diffusion and, therefore, requires _______________ be expended. 29. Moving sodium from inside the cell to the outside environment requires _______________ transport. 30. Which of the following is not an active transport process? a. b. c. d. pumping facilitated diffusion endocytosis exocytosis 31. T or F: The process by which large molecules (proteins, etc.) move into the cell is termed endocytosis. ________ 32. Endocytosis can be divided into two processes: _______________ and _______________. 33. Phagocytosis means what? ____________ _______________ 34. Insulin-secreting cells use which of the following to release insulin? a. b. c. d. facilitated diffusion pinocytosis exocytosis insocytosis 35. Both endocytosis and exocytosis involve a breakdown of what to occur? __________ _______________ _______________ B. Protein Synthesis and Cellular Reproduction Review: (These are sample questions I would expect you to be able to answer regarding this topic for your test.) 1. The general trend in protein synthesis is what? ________ ________ ________ 2. T or F: There is no difference between DNA and RNA. They are, in fact, the same structure. ________ 3. A molecule contains uracil. Is it DNA or RNA? ________ {61} 4. A molecule has an anticodon. Is it DNA, mRNA, or tRNA? ________ 5. A DNA strand has the following 6 bases: Guanine - Adenine - Cytosine - Thymine - Guanine - Guanine What will the bases be on the mRNA that forms in transcription? ________ - ________ ________ - ________ - ________ - ________ 6. How many codons is this? ________ 7. How many amino acids will this code for? ________ 8. How many tRNA will be attracted to this portion of the mRNA? ________ 9. What will be the anticodons on this tRNA? First one: ________ - ________ - ________ Second one: ________ - ________ - ________ Everyone talks a lot about genes, but most people don’t know what they are. A gene simply is a recipe for a protein or a portion of a protein. That’s it. All of the traits that we have are determined by proteins, and the recipes for the proteins are in the DNA. Although the genes that we have determine a lot of physical traits, they do not determine everything about us. There is a constant battle between genetics, environment, and the spiritual realm. This is often characterized as “nature versus nurture.” Our genes provide a basic blueprint for what we look like and how we act. However, our environment and spiritual factors then shape that blueprint into a final product. You might have the genes of an athlete. However, if you never work out, eat the wrong foods, etc., you will still be overweight and inactive. Most scientists believe (and they are certainly not sure) that genes provide TENDENCIES and that environmental and spiritual factors either allow us to follow those tendencies or fight them. For example, there is a gene present in 65% of alcoholics and 35% of non-alcoholics. Scientists think that this gene gives us the tendency towards alcoholism. However, 25% of alcoholics don’t have that gene but are nevertheless alcoholics. Also, 30% of non-alcoholics have the gene and are not alcoholics. Thus, the gene gives a TENDENCY towards alcoholism. People with the gene are not destined to be alcoholics - they can fight it. You don’t have to have the gene to be an alcoholic, either. Bad choices can be enough to make you one. Thus, genes give us tendencies, while environmental and spiritual factors allow us to either go along with those tendencies or fight them. Genes are stored in chromosomes. A human being has 23 PAIRS of chromosomes. Thus, there are 46 total chromosomes. Each pair has the same set of genes. The genes are not the same, but {62} the mapping is the same. Let me make sure you understand what I mean. Suppose, for example, your eye color was determined by one gene (it is not, but suppose it were). If the gene that determines eye color were on chromosome pair 14, then you would have 2 genes for eye color, one on each of the chromosomes in the pair. Now, the first gene might be for blue eyes and the second for green eyes, but they would both be genes for eye color. That’s what we mean by HOMOLOGOUS PAIRS. Each pair of chromosomes carry the same gene map. The genes might be for different traits, but each chromosome in the pair affects the same traits. Thus, if the gene for hair color (once again, there are more than one, but suppose there were just one) were on chromosome pair 12, you would have 2 genes for hair color: one on the first chromosome in pair 12 and one on the second. The first might be for blonde hair and the second for red hair, so they need not be the same. They both affect hair color, however. 10. When a cell is not reproducing, it is said to be in which of the following? a. b. c. d. prophase interphase metaphase anaphase 11. The “four broad steps” of mitosis--in order from start to finish--are _______________, _______________, _______________, and _______________ 12. During which “broad step” are the duplicate chromosomes and original chromosomes pulled apart? _______________ Table of Contents Start {63} Answers & Links: Lesson 2: An Organizational Overview and Some Review, Part 2 http://redwagontutorials.com/AD/HandoutsH/Module01/1stOverhead02.htm http://redwagontutorials.com/AD/HandoutsH/Module01/2ndOverhead.htm http://redwagontutorials.com/AD/HandoutsH/Module01/3rdOverhead.htm http://www.redwagontutorials.com/php/ http://redwagontutorials.com/AD/HandoutsH/Module01/HModule1SG.htm http://redwagontutorials.com/AD/HandoutsH/Module01/SampleInformalReport.htm http://redwagontutorials.com/AD/HandoutsH/Module01/FormalReport2a.htm Please watch this video before class starts or the session video is viewed: http://www.youtube.com/watch?v=S7CJ7xZOjm0 Today’s class has two parts. The first part is new materials beyond your basic biology course. The second part is review material which you should know regarding the topics of protein synthesis and cellular reproduction. I will go over the first part (A) during class. If there is time, I will go over the second part (B). Both parts (A and B) are testable. A. Lecture: 1. T or F: A beautiful example of structure and function can be seen in the cell’s plasma membrane. ________ Answer: True. A beautiful example of structure and function can be seen in the cell’s plasma membrane. http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.6.htm 2. The plasma membrane is important to the life of the cell because it limits what goes ________ and ________ of the cell. {64} Answer: The plasma membrane is important to the life of the cell because it limits what goes in and out of the cell. http://upload.wikimedia.org/wikipedia/commons/2/2a/Semipermeable_membrane.png 3. Three kinds of molecules found in the plasma membrane include _______________, _______________, and _______________. Answer: Three kinds of molecules found in the plasma membrane include phospholipids, proteins, and cholesterol. http://www.ucl.ac.uk/~sjjgsca/CellMembrane.html http://en.wikipedia.org/wiki/Protein http://en.wikipedia.org/wiki/Cholesterol 4. A phospholipid is which of the following? a. b. c. d. a fat molecule with one fatty acid replaced by a phosphate group polar on one side and non-polar on the other “hydrophilic” on one end and “hydrophobic” on the other All the above are correct. Answer: The correct answer is (d). A phospholipid is a fat molecule with one fatty acid replaced by a phosphate group, which is polar on one side and non-polar on the other, which makes it “hydrophilic” on one end and “hydrophobic” on the other. http://telstar.ote.cmu.edu/biology/MembranePage/images/phospholipid.jpg 5. T or F: Phospholipids will re-orient themselves so that the polar heads of the phospholipid bilayer are pointed into the cell and out into the watery environment. ________ Answer: True. Phospholipids will re-orient themselves so that the polar heads of the phospholipid bilayer are pointed into the cell and out into the watery environment. http://micro.magnet.fsu.edu/cells/plasmamembrane/plasmamembrane.html 6. Like icebergs in the sea, what can be found floating in the phospholipid bilayer? _______________ Answer: Like icebergs in the sea, proteins can be found floating in the phospholipid bilayer. 7. The three kinds of protein found in the phospholipid bilayer are _______________ _______________, _______________, and _______________ _______________. {65} Answer: The three kinds of protein found in the phospholipid bilayer are channel proteins, glycoproteins, and receptor proteins. 8. Which kind of phospholipid bilayer protein acts as a marker, allowing cells to recognize each other? a. b. c. d. glycoproteins channel proteins receptor proteins phosphoproteins Answer: The correct answer is (a). Glycoproteins found in the phospholipid bilayer act as a markers, allowing cells to recognize each other. http://www.galab.de/technologies/img/glycos.gif 9. T or F: Nerve cells release chemicals which bind with channel proteins on a muscle cell, causing the muscle to contract. ________ Answer: False. Nerve cells release chemicals, which bind with receptor proteins on a muscle cell, causing the muscle to contract. http://scientopia.org/blogs/scicurious/files/2010/11/neuromuscular-junction.jpg 10. _______________ stabilizes the cell membrane and gives the plasma membrane the right amount of firmness. Answer: Cholesterol stabilizes the cell membrane and gives the plasma membrane the right amount of firmness. http://www.uic.edu/classes/bios/bios100/summer2002/cholesterol.jpg 11. The words “fluid” and “mosaic” found in the fluid mosaic model description refer to what, respectively? fluid = _______________ ____________ and mosaic = _______________ Answer: The words “fluid” and “mosaic” found in the fluid mosaic model description refer to the phospholipid bilayer and the three kinds of proteins found floating in the bilayer, respectively. http://byallohgee.wikispaces.com/file/view/c8.7x7.fluid.mosaic.jpg/41405687/c8.7x7.fluid.mosai c.jpg 12. Which of the following define(s) a function of the plasma membrane? a. It delimits the cell. b. It provides receptors. {66} c. It allows for defective permeability. d. All the above are membrane functions. Answer: The correct answer is (a). Three functions of the plasma membrane include (1) it delimits the cell, (2) it provides receptors, and (3) it allows for selective permeability. 13. T or F: In Type I diabetes, the person does not make insulin. In Type II diabetes, the glucose receptors don’t respond to the glucose present. ________ Answer: False. In Type I diabetes, the person does not make insulin. In Type II diabetes, the insulin receptors don’t respond to the insulin present. http://dtc.ucsf.edu/ 14. The ability of the plasma membrane to let certain materials in or out of the cell while restricting others is termed _______________ _______________. Answer: The ability of the plasma membrane to let certain materials in or out of the cell while restricting others is termed selective permeability. http://www.biologyguide.net/biol1/3b_exchange.htm 15. The first reason plasma membranes are selectively permeable is due to the fact that polar substances dissolve _______________ and nonpolar substances dissolve _______________. Answer: The first reason plasma membranes are selectively permeable is due to the fact that polar substances dissolve polar and nonpolar substances dissolve nonpolar. The tails of the phospholipids are made up of nonpolar fatty acids. Fatty substances or substances which dissolve in fat can get into the cell easily because they are nonpolar: they pass right through the plasma membrane. (example: fatty soluble vitamins and nicotine patches.) Polar substances must use channel proteins to enter the cell. http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.11.htm 16. Water molecules move in and out through channel proteins because they are which of the following? a. b. c. d. polar in nature the right size have the correct charge all the above Answer: The correct answer is (d). Water molecules move in and out through channel proteins because they are polar in nature, the right size, and have the correct charge. http://www1.lsbu.ac.uk/water/molecule.html {67} 17. T or F: The amino acids in the channel proteins are oriented so that they form positive or negative charges in the channel, which repel like charges and attract opposite charges. ________ Answer: True. The amino acids in the channel proteins are oriented so that they form positive or negative charges in the channel, which repel like charges and attract opposite charges. http://www.cipsm.de/en/publications/researchAreaF/2007/Biel_Function_and_Dysfunction_of_ CNG_Channels/biel_anim.gif 18. In _______________ _______________, a carrier protein is designed for a specificallyshaped molecule. Answer: In mediated transport, a carrier protein is designed for a specifically-shaped molecule. The molecule can enter the protein because it fits. http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.7.htm 19. What three conditions must be considered for mediated transport to work well? _______________, _______________, and _______________ Answer: For mediated transport to work well, specificity, competition, and saturation are conditions that must be considered. http://www.accessexcellence.org/RC/VL/GG/ecb/ecb_images/12_04_passive_active_transport.jp g 20. When similarly-shaped molecules fight to use the same carrier protein, which mediated transport condition is exhibited? _______________ Answer: Competition is exhibited when similarly-shaped molecules “fight” or “compete” to use the carrier protein. Specificity requires that the molecule have a specific shape. Saturation deals with the fact that there is a limit to how many molecules a carrier protein can accept in a certain period of time. 21. Which of the following is not a factor leading to the selective permeability of the plasma membrane? a. b. c. d. the membrane’s polar nature the presence of small molecule channel proteins the channel protein’s overall electrical charge the transport rate of large molecules through the plasma membrane Answer: (a) is not a factor. Factors leading to the selective permeability of the plasma membrane include (1) the membrane’s fatty or non-polar nature, (2) the presence of small {68} molecule channel proteins, (3) the channel protein’s, overall electrical charge, and (4) the transport rate of large molecules through the plasma membrane. http://faculty.stcc.edu/aandp/ap/ap1pages/units1to4/introduction/selectiv.htm 22. Molecules can enter the cell through one of four pathways: (1) dissolving through the phospholipid bilayer; (2) entering through channel proteins due to their small size; (3) entering through charged channel proteins due to their charge size; or (4) employing carrier proteins. Indicate which method (1, 2, 3, or 4) is being used by the following molecules. a. fructose ________ Answer: 4, fructose is a simple sugar; hence, it needs a carrier protein. http://media.mercola.com/ImageServer/public/2010/January/Sugars101.jpg b. fluoride ions ________ Answer: 3, fluoride ions are charged molecules; hence, they need charged channel proteins http://en.wikipedia.org/wiki/Fluoride c. lipids ________ Answer: 1, lipids are fats; hence, they dissolve through the phospholipid bilayer http://en.wikipedia.org/wiki/Lipid d. water ________ Answer: 2, water molecules are small enough to move through simple channel proteins http://www.geo.arizona.edu/xtal/nats101/9_7.jpg 23. T or F: The four pathways above use two basic kinds of plasma membrane transport: passive transport and active transport. ________ Answer: True. The four pathways above use two basic kinds of plasma membrane transport: passive transport and active transport. http://www.biology4kids.com/files/cell2_passivetran.html http://www.biology4kids.com/files/cell2_activetran.html 24. Passive transport is accomplished by what two processes? _______________ and _______________ _______________. Answer: Passive transport is accomplished by two processes: diffusion and facilitated diffusion. http://bcs.whfreeman.com/thelifewire/content/chp05/0502001.html {69} 25. Diffusion is the movement of ions or molecules from an area of ____________ concentration to an area of ____________ concentration. Answer: Diffusion is the movement of ions or molecules from an area of high concentration to an area of low concentration. 26. Diffusion using mediated transport is termed which of the following? a. b. c. d. mediated diffusion diffusion transport facilitated diffusion a weird and strange event Answer: The correct answer is (c). Diffusion using mediated transport is termed facilitated diffusion. http://en.wikipedia.org/wiki/Facilitated_diffusion 27. T or F: Both diffusion and facilitated diffusion require energy (derived from the breakdown of ATP) to be expended by the cell. ________ Answer: False. Neither diffusion nor facilitated diffusion require energy (derived from the breakdown of ATP) to be expended by the cell. 28. Active transport is movement against the dictates of diffusion and, therefore, requires _______________ to be expended. Answer: Active transport is movement against the dictates of diffusion and, therefore, requires energy to be expended. http://en.wikipedia.org/wiki/Active_transport 29. Moving sodium from inside the cell to the outside environment requires _______________ transport. Answer: Sodium is in low concentration inside the cell and is highly concentrated outside the cell. Moving sodium from inside the cell to the outside environment requires active transport, requiring energy to be expended. Potassium has a high concentration inside the cell and has a low concentration outside the cell. Moving potassium from outside the cell to the inside environment requires active transport, requiring energy again to be expended. http://bcs.whfreeman.com/thelifewire/content/chp05/0502002.html 30. Which of the following is not an active transport process? a. pumping {70} b. facilitated diffusion c. endocytosis d. exocytosis Answer: The correct answer is (b). Facilitated diffusion is not an active transport process because it uses no energy. http://highered.mcgrawhill.com/sites/0072495855/student_view0/chapter2/animation__how_facilitated_diffusion_work s.html 31. T or F: The process by which large molecules (proteins, etc.) move into the cell is termed endocytosis. ________ Answer: True. The process by which large molecules (proteins, etc.) move into the cell is termed endocytosis. http://cellbiology.med.unsw.edu.au/units/images/endocytosis_types.png 32. Endocytosis can be divided into two processes: _______________ and _______________. Answer: Endocytosis can be divided into two processes: pinocytosis and phagocytosis. http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.8.htm http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.9.htm 33. Phagocytosis means what? ____________ _______________ Answer: Phagocytosis means “cell eating.” And pinocytosis means “cell drinking.” 34. Insulin-secreting cells use which of the following to release insulin? a. b. c. d. facilitated diffusion pinocytosis exocytosis insocytosis Answer: The correct answer is (c). Insulin-secreting cells use exocytosis to release insulin. Exocytosis is the transportation of materials from inside the cell to outside the cell. http://www.linkpublishing.com/exocytosis5.jpg 35. Both endocytosis and exocytosis involve a breakdown of what to occur? __________ _______________ _______________ {71} Answer: Both endocytosis and exocytosis involve a breakdown of the plasma membrane to occur. http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.10.htm http://www.ideacenter.org/contentmgr/showdetails.php/id/838 B. Protein Synthesis and Cellular Reproduction Review: (These are sample questions I would expect you to be able to answer regarding this topic for your test.) 1. The general trend in protein synthesis is what? ________ ________ ________ Answer: The general trend in protein synthesis is DNA RNA Protein. http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.4.htm 2. T or F: There is no difference between DNA and RNA. They are, in fact, the same structure. ________ http://www.accessexcellence.org/RC/VL/GG/rna2.html Answer: False. The differences between RNA and DNA are as follows: a. RNA (left) is composed of a single strand. DNA (right) has 2 strands that form a double helix. b. The sugar on the nucleotide in RNA is RIBOSE. The sugar on the nucleotide in DNA is DEOXYRIBOSE. c. DNA has the 4 nucleotide bases ADENINE, THYMINE, CYTOSINE, and GUANINE. That’s what the ATCG at the top of the DNA stands for. RNA has the 4 nucleotide bases ADENINE, URACIL, CYTOSINE, and GUANINE. That’s what the AUCG at the top of the DNA stands for. http://redwagontutorials.com/AD/HandoutsH/Module01/protsyn1.gif http://themedicalbiochemistrypage.org/protein-synthesis.html http://www.accessexcellence.org/AB/GG/protein_synthesis.html 3. A molecule contains uracil. Is it DNA or RNA? ________ Answer: Only RNA has uracil. DNA has thymine. {72} 4. A molecule has an anticodon. Is it DNA, mRNA, or tRNA? ________ Answer: It is tRNA. mRNA has codons. tRNA has anticodons. 5. A DNA strand has the following 6 bases: Guanine - Adenine - Cytosine - Thymine - Guanine – Guanine What will the bases be on the mRNA that forms in transcription? ________ - ________ ________ - ________ - ________ - ________ Answer: Cytosine - Uracil - Guanine - Adenine - Cytosine - Cytosine 6. How many codons is this? ________ Answer: 2, there are 3 bases per codon. 7. How many amino acids will this code for? ________ Answer: 2, one codon means one amino acid. 8. How many tRNA will be attracted to this portion of the mRNA? ________ Answer: 2, one for each codon. 9. What will be the anticodons on this tRNA? First one: ________ - ________ - ________ Answer: Guanine - Adenine - Cytosine Second one: ________ - ________ - ________ Answer: Uracil - Guanine – Guanine Everyone talks a lot about genes, but most people don’t know what they are. A gene simply is a recipe for a protein or a portion of a protein. That’s it. All of the traits that we have are determined by proteins, and the recipes for the proteins are in the DNA. Although the genes that we have determine a lot of physical traits, they do not determine everything about us. There is a constant battle between genetics, environment, and the spiritual realm. This is often characterized as “nature versus nurture.” Our genes provide a basic blueprint for what we look like and how we act. However, our environment and spiritual factors then shape that blueprint into a final product. You might have the genes of an athlete. However, if you never work out, eat the wrong foods, etc., you will still be overweight and inactive. {73} Most scientists believe (and they are certainly not sure) that genes provide TENDENCIES and that environmental and spiritual factors either allow us to follow those tendencies or fight them. For example, there is a gene present in 65% of alcoholics and 35% of non-alcoholics. Scientists think that this gene gives us the tendency towards alcoholism. However, 25% of alcoholics don’t have that gene but are nevertheless alcoholics. Also 30% of non-alcoholics have the gene and are not alcoholics. Thus, the gene gives a TENDENCY towards alcoholism. People with the gene are not destined to be alcoholics - they can fight it. You don’t have to have the gene to be an alcoholic, either. Bad choices can be enough to make you one. Thus, genes give us tendencies, while environmental and spiritual factors allow us to either go along with those tendencies or fight them. Genes are stored in chromosomes. http://redwagontutorials.com/AD/HandoutsH/Module01/kary2.gif A human being has 23 PAIRS of chromosomes. Thus, there are 46 total chromosomes. Each pair has the same set of genes. The genes are not the same, but the mapping is the same. Let me make sure you understand what I mean. Suppose, for example, your eye color was determined by one gene (it is not, but suppose it were). If the gene that determines eye color were on chromosome pair 14, then you would have 2 genes for eye color, one on each of the chromosomes in the pair. Now, the first gene might be for blue eyes and the second for green eyes, but they would both be genes for eye color. That’s what we mean by HOMOLOGOUS PAIRS. Each pair of chromosomes carry the same gene map. The genes might be for different traits, but each chromosome in the pair affects the same traits. Thus, if the gene for hair color (once again, there are more than one, but suppose there were just one) were on chromosome pair 12, you would have 2 genes for hair color: one on the first chromosome in pair 12 and one on the second. The first might be for blonde hair and the second for red hair, so they need not be the same. They both affect hair color, however. 10. When a cell is not reproducing, it is said to be in which of the following? a. b. c. d. prophase interphase metaphase anaphase Answer: The correct answer is (b). When a cell is not reproducing, it is said to be in interphase. http://redwagontutorials.com/AD/HandoutsH/Module01/Figure1.5.htm 11. The “four broad steps” of mitosis--in order from start to finish--are _______________, _______________, _______________, and _______________ {74} Answer: The “four broad steps” of mitosis in order from start to finish are prophase, anaphase, metaphase, and telophase. Mitosis: http://royaleb.files.wordpress.com/2009/04/mitosis_phases1.jpg 12. During which “broad step” are the duplicate chromosomes and original chromosomes pulled apart? _______________ Answer: During anaphase, the duplicate chromosomes and original chromosomes are pulled apart. http://redwagontutorials.com/AD/HandoutsH/Module01/kary1.gif Table of Contents Start {75} Formal Report Example #1: Miss CC 10/13/14 Pond Observation A. Purpose: The purpose of this experiment is to study the environment of a pond. It is to observe the ecosystem of a pond. This involves taking note of the different organisms supported by the pond environment, their interactions with one another, and the impact of the environment on the organisms themselves. This experiment will provide a better understanding of the organisms in a pond environment and how certain conditions promote or hinder their growth. There are three types of freshwater ecosystems: lentic, lotic, and wetland. The ecosystem studied in this experiment is the lentic ecosystem, that is, the ecosystem of slow-moving water (Wikipedia). An important part of the pond ecosystem is the nitrogen cycle, which describes how organic waste is broken down. Cyanobacteria, also called blue-green algae, are an important part of this cycle as they are one of the few types of organisms that can convert nitrogen in the atmosphere into organic nitrate (Veterinary). As they are photosynthetic, cyanobacteria require light for metabolism and float on the water's surface (Wile). Cyanobacteria can exist as single microscopic cells or groups of cells, but lack of water turbulence, warm temperature, and levels of nutrients such as nitrogen and phosphorus will allow them to bloom (California). Some species of cyanobacteria produce toxins that are harmful to humans and animals (World). This experiment hopes to show the relationship between the environmental conditions and the abundance of certain organisms. Attributes of the pond environment directly affect the life there. Certain conditions will allow some organisms to prosper while limiting the growth of others. These conditions, among others, include the temperature of the water and air, the availability of nutrients in the water, and the amount of daily sunlight. This topic is of interest to scientists because the model of the pond ecosystem can provide a basis for how to analyze interactions between organisms in other ecosystems. It can also provide a point of reference for which to compare and contrast with. As the pond's ecosystem is relatively simple, it functions as a simple model that may help the understanding of more complex ecosystems. The microorganisms in the pond ecosystem serve as examples for how more complex organisms can benefit and support one another. Hypothesis: If the weather is warm, the pond is exposed to sunlight, and the water is calm, then blue-green algae blooms will be visible. B. Equipment: {76} 1. 2. 3. 4. C. A ladle A pond A clear jar A camera Procedure: 1. Set the jars aside and walk slowly around the pond, sitting occasionally to observe all of the surroundings. 2. Examine the pond water and try to find blue-green algae blooms. Take note of where the blooms are found, and compare the conditions of that particular spot to another spot without blue-green algae blooms. 3. Ladle some pond water into the jar. D. Observations: 1. Neither ducks nor any other birds were seen around the pond. Nor were there any bird droppings, but scattered bread crumbs on the ground suggest that there may have been ducks present earlier in the day. 2. Cicadas and crickets were heard, but not seen. 3. A new fountain installed in the center of the pond was noted. 4. There were several families fishing in the pond, but throughout the entire duration of the experiment, none of them caught any fish. 5. There was an abundance of water plants and algae growing at the bottom of the pond, but no fish were visible in the pond water. 6. The walkway under the bridge over the pond was flooded. The water covering the concrete was ankle deep. 7. The water sample collected from the pond was translucent but a light brown color. The water emitted a musty and earthy odor. There were fine particles of dirt swirling around that eventually settled on the bottom. 8. The only place blue-green algae blooms were seen in the pond was in a very shallow area that was almost completely isolated from the rest of the pond water in a miniature cove. 9. There were several small pools of water alongside the pond. An abundance of blooms was found in one of these pools, but others did not contain any blooms. 10. The blooms, all of which were lime green, observed in the pool were more yellowish than the blooms in the pond. 11. The blooms in the pond were more spread out and were thinner, while the blooms in the pool formed in blobs with a bubbly texture. 12. Only a few water insects were observed in the pool. None were seen in the pond. E. Conclusions: The data collected appears to both support and negate the hypothesis. The lack of blooms (excluding the isolated section of the pond) can be explained by the presence of the new fountain, but the distinct odor of the pond water suggests that cyanobacteria may exist as single cells in the water. Cyanobacteria naturally exist in the aquatic ecosystem, but blooms occur when certain conditions are met. In this case, the fountain was continuously disturbing the water, {77} making it hard for the individual cells to group together. However, not all of the pools outside of the pond, which held calm water, contained blooms. A possible explanation for this may be the disturbance caused by the recent rain, or that majority of those pools formed during the rainstorm. The flooding of the walkway provides strong evidence for this idea. One way to improve the experiment would be to bring latex gloves and goggles, as contact with cyanobacteria can cause irritation of the eyes and skin. Another way would be to visit the pond when the water level is lower, so that more detailed observations of the pond life can be made. Yet another way would be to bring a high powered flashlight to shine into the pond depths. Also, contacting the community president and requesting the fountain to be turned off for a period of time would also greatly improve the experiment. An idea for further research would be to conduct the experiment multiple times, isolating specific environmental factors in order to determine which one is most crucial for blue-green algae to prosper. For example, a trial could be conducted on a windy day and another on a day with no or very little wind. Another idea is to track the abundance of blooms following a rainstorm. Lastly, an experiment could be conducted to compare the amount of toxins released by cyanobacteria when no blooms are visible versus when there exists an abundance of blooms. F. Bibliography: California Department of Public Health. Blue-Green Algae (Cyanobacteria) Blooms. 2012. Domain: http://www.cdph.ca.gov Document: /healthinfo/environhealth/water/Pages/Bluegreenalgae.aspx Department of Health and Human Services, Centers for Disease Control and Prevention. Harmful Algal Blloms (HABs). 2012. Domain: http://www.cdc.gov Document: /hab/cyanobacteria/facts.htm Rosenoff, Steven. Classroom/Internet Lecture. October 2014. Veterinary & Aquatic Services Department, Drs. Foster & Smith, Inc. Pond Ecology: How to Understand It and Use it to Design and Maintain Ponds. 2008. Domain: http://www.peteducation.com Document: /article.cfm?cls=16&cat=1917&articleid=3472 Wikipedia, the Free Encyclopedia. Aquatic Ecosystems. 2012. Domain: http://en.wikipedia.org Document: /wiki/Aquatic_ecosystem Wile, Dr. Jay. L. and Durnell, Marilyn F. Exploring Creation with Biology, 2nd Ed. Apologia Educational Ministries, Inc. 2005. {78} Table of Contents Start {79} Module 1 Test Review: 20 - Matching 10 - Multiple Choice 11 – Fill in the Blanks 3 – Essay 44 – Total (50 points possible) Questions are taken from the Study Guide questions, OYO questions, figures presented in the textbook, Lecture Notes, and the practice test in your Solutions Manual. 60 minutes to take the Test. It is closed-book and closed-notes. Parents do need to initial the bottom of the Test. Example questions follow: A. Matching - Match the term or structure with its definition: 1 point each A. B. C. D. Microscopic anatomy Physiology Lysosome Anticodon 1. The study of the microscopic structures of an organism 2. Binds to a codon. 3. Breaks down proteins, polysaccharides, nucleic acids, and lipids 4. The study of the functions of an organism and its parts B. Multiple Choice - Select the best possible answer for the following: 1 point each 5. Which of the following would make up the lining of the stomach? a. b. c. d. e. nervous tissue muscle tissue connective tissue epithelial tissue None of the above are found in the stomach. 6. Which of the following is the proper ordering for the phases of mitosis? {80} a. b. c. d. e. interphase, metaphase, anaphase, telophase prophase, metaphase, anaphase, telophase metaphase, anaphase, telophase, prophase anaphase, metaphase, prophase, telophase prophase, metaphase, anaphase, interphase C. Fill in the blank with the correct word: 1 point each (Correct spelling of terms required) 7. Homeostasis is threatened by _______________. 8. _______________ concentrates on the structures of an organism. D. Essay - Answer the following in one or two complete paragraphs: 3 points each (1 pt for composition; 2 pts for content) 9. A glucose molecule travels into a cell via a carrier protein. If that process required no ATP, what can you say about the relative concentration of glucose inside and outside of the cell? Explain your answer in paragraph form. Module 1 Test Table of Contents Start . {81}