Page 1 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG Faculty of Health Sciences MB BCh IV / GEMP II INTEGRATED BASIC MEDICAL AND HUMAN SCIENCES (SCMD 4000) Block Examination 3 (NEUROSCIENCES) Paper 1 MCQ Model Answers Venue: _____________________________________ Group Number: _____________________________ Seat Number: _____________________________ Student Number: _____________________________ Time allowed: 120 minutes Date: 15th October 2009 Page 2 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ GENERAL INSTRUCTIONS Please read the following carefully: 1. There are 60 multiple choice questions (MCQ’s) in this paper. 2. Two (2) minutes have been allocated per question. 3. Write your group number, seat number and student number on each page of this question paper. 4. Please hand in all cellphones, calculators and removable drives prior to the start of the examination. 5. You may not remove any question papers from the examination room. A-TYPE QUESTIONS Select the single best answer to each question. (Note: several options may be correct but only one is the best answer.) Answers must be entered on the question paper and online. If you give more than one answer for a question, you will score zero for that question. There will be no penalty for incorrect answers. If you do not know an answer you may leave it blank, in which case you will neither earn a mark nor be penalised. X-TYPE QUESTIONS There is at least one correct statement and at least one incorrect statement. Identify BOTH the correct and incorrect statements. Answers must be entered on the question paper and online. If you are unsure of a statement do not leave it blank (Tick the “Don’t know” box) Negative marking will be applied to wrong answers but negative marks will not be carried forward. This means the minimum mark for a question is zero. R-TYPE QUESTIONS Here you are offered a number of answers. This is followed by a set of questions. Select the single best answer to each question. Note that each answer may be used more than once or not at all unless you are specifically instructed otherwise. Fill in your answers in the spaces provided on the question paper and online. If you do not know an answer you may leave it blank, in which case you will neither earn a mark nor be penalised. Note: Each A-type, X-type and R-type question has the same mark value. Answers must be entered on the question paper and online. Please SUBMIT your exam. Page 3 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ 1. Seat No: _____________ Student No: _________________ A - Types Mr. B, a 57 year old retired schoolteacher was brought into casualty this morning in a wheelchair by his daughter. She says that he has been unsteady on his feet since last night, and is now unable to stand up without falling over to his left side. Following a CT scan, it is discovered that Mr B has developed a thrombosis of the posterior spinal artery on the left side, interrupting the ascending tracts of the posterior column of the spinal cord on that side. Which of the following statements most applies to Mr B? a. He will be unable to perceive pain and temperature on the right side of his body b. He will not have 2-point tactile discrimination sense on his left side. c. He has right-sided sensory ataxia d. Position sense will be lost, but vibration sense will be intact on the affected side. e. He has a condition called the Brown-Sequard syndrome 2. The development of the neural tube is a crucial aspect of embryonic development and leads to the formation of the brain and spinal cord. Initially the neural tube extends into the caudal part of the developing embryo but due to changes in its growth and that of its surroundings, it will appear to retreat up the developing vertebral column. At 3. birth, the conus medullaris of the spinal cord lies at the level of: a. lumbar vertebra 7 b. sacral vertebra 5 c. the disc between lumbar vertebra 1 and 2 d. lumbar vertebra 3 e. the disc between sacral vertebra 1 and 2. In the case of the abnormality spina bifida, experimental studies have shown that the abnormality in the vertebral column is due to an underlying defect/disruption in neural tube development. Thus, spina bifida is often accompanied by defects in the neural tube and its meningeal coverings. The condition described as spina bifida meningocoele consists of a: a. A neural tube as well as the vertebral arch which have both failed to close b. Herniated meningeal sac often filled with cerebrospinal fluid, which protrude through a deficiency of the vertebral arches. c. Both a normal spinal cord and meninges but with a spino-laminar defect affecting one or more vertebrae. The effected portion of the back is covered with normal skin. d. A herniated spinal cord covered by meninges which protrude through the vertebral deficiency. e. An intact neural tube, covered by meninges and intact vertebral arches 4. Regarding oculomotor control, when the head moves right, the eyes: a. Move separately to each other b. Move to the right c. Move up and to the right d. Move down and to the left e. Move to the left Page 4 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ 5. Seat No: _____________ Student No: _________________ A 17-year-old male presents with a four-day history of auditory hallucinations, delusions of grandeur and disorganized behaviour. A collateral history reveals that his mother died unexpectedly one day prior to the onset of his symptoms. This is his first psychiatric presentation and he does not abuse substances. On mental status examination he is oddly groomed and has formal thought disorder. His physical examination is normal. He is treated and recovers totally within 2 weeks, with full return to his premorbid level of functioning. The most likely diagnosis in this case is: a. Brief Psychotic Disorder b. Schizophreniform Disorder c. Bipolar mania episode with psychosis d. Schizophrenia e. Schizoaffective Disorder 6. A 40-year-old man sees you due to poor sleep two weeks after he was held up at gunpoint. He has experienced difficulty falling or staying asleep as well as difficulty concentrating. He reports avoidance of reminders of the event and has intrusive recollections. The most likely diagnosis is: a. Acute Stress Disorder b. Adjustment disorder c. Dysthymia d. Major depression e. Post Traumatic Stress Disorder 7. A 25-year-old man reports intrusive concerns about having hit pedestrians while driving and turns back to check his route while driving. He has to recount money before bank deposits several times and has intrusive distressing thoughts that he may hurt his young son. He feels his anxiety is unreasonable. His most likely diagnosis is: a. Adjustment disorder b. Generalized anxiety disorder c. Obsessive compulsive disorder d. Simple phobia e. Social phobia 8. A 29-year-old man reports ongoing anxiety about his health despite extensive medical investigations. He has had 2 episodes of right-sided chest pain with shortness of breath and palpitations without any clear precipitant. He is now avoiding social events after the original attack at a social event.The most likely diagnosis is: a. Adjustment Disorder without agoraphobia b. Generalized Anxiety Disorder without agoraphobia c. Panic Disorder with agoraphobia d. Social Phobia with agoraphobia e. Social Phobia without agoraphobia Page 5 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ 9. Seat No: _____________ Student No: _________________ The family brings a 35-year-old woman after conflict at home. She has not slept for two nights and believes she is a prophet in the church. She became violent after an argument at home as the family did not support her plans to start a new business. When seen she is very talkative and reports increased energy. She suddenly starts crying and says she wishes she were dead, as her family have rejected her. The most likely diagnosis is: a. Major depression with psychosis b. Bipolar Type I - mania c. Bipolar Type II - depression d. Schizoaffective disorder e. Personality disorder with dissciation 10. A 65-year-old man has a 5-day history of confusion that is worse at night. He is disorientated for the place and date. He is fearful about his safety and reports hearing the voice of a man who wants to kill him. He was moved into an old age home 1 month ago. He appears sedated but has had no medication you are told. The most likely diagnosis is: a. Adjustment Disorder b. Delirium c. Dementia d. Brief Psychotic Disorder e. Acute Stress Disorder 11. A child of 12 years is referred to the local Mental Health Clinic, with complaints from his teachers that he is under performing. He is described as 'too playful' and has poor concentration. His parents have frequent heated quarrels with him, usually about his failure to complete his homework. He dislikes school and has been truant in the past. He has repeated grade 2 and is now in grade 3 and is performing below average. His worst subjects are reading, writing and spelling. He has also recently developed bullying.behaviour towards his younger sister, who is doing well at school. The most appropriate first step in management would be: a. Taking a detailed family history of psychiatric disorders b. Administering psycho-educational tests c. Ordering blood tests to assess liver function, FBC and glucose levels d. Administering a self-report questionnaire to assess if he is depressed e. Organising a social work referral to investigate the child's home circumstances 12. Which of the following is the correct definition for coma? a. Its state of quadriplegia, vertical eye movements and inability to talk b. Its a state of disturbed consciousness with motor restlessness, hallucinations and disorientation c. Its a state of drowsiness and unresponsiveness to external stimuli d. Its condition characterized by brief loss of consciousness, followed by full recovery without focal signs e. Its a state of continuous fits with recovery of consciousness between the intervals of fits Page 6 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 13. Mr John Mlambo who was involved in a motor vehicle accident is brought to you in the emergency department. On examining him you find that he cannot open his eyes, he localizes to pain and is unable to talk and can only make sounds. What is the correct Glasgow Coma Scale (GCS)? a. GCS = 14 b. GCS = 5 c. GCS = 6 d. GCS = 8 e. GCS = 12 14. Mr Jerry Vilakazi, a known hypertensive patient who often defaults treatment presents to the emergency medical department, with left hemiplegia and dilated right pupil. Which of the following are appropriate investigation/s in this case scenario? a. A full blood count (FBC), urea and electrolytes and (U+E) b. Skull x-ray c. Skull bone scan d. Cranial ultrasound e. CT-Brain/MRI Brain 15. X - Types Regarding the functional and anatomical divisions of the cerebellum a. The neocerebellum is involved with maintaining balance. True False b. The archicerebellum is composed of the flocculonodular lobe and fastigial nucleus. True False c. The archicerebellum receives afferent fibres from the vestibular nuclei. True False d. The paleocerebellum is composed of the cerebellar hemispheres and dentate nucleus. True False e. The paleocerebellum is involved with the maintenance of muscle tone and posture. True False Page 7 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 16. Concerning sensory pathways of the nervous system: a. The lateral spinothalamic tract conveys pain and temperature impulses for the contralateral side of the body. True False b. The branches of fibres which transmit pain impulses may ascend up to 10 spinal levels before decussating. True False c. The dorsal columns convey proprioception and discriminative touch for the contralateral side of the body. True False d. Fibres within the fasciculus gracilis of the dorsal column transmit impulses from the lower limbs. True False e. Fibres of the ventral (anterior) spinocerebellar tracts pass through the inferior cerebellar peduncle. True False a. Fibres of the corticospinal tracts form the fasciculi cuneatus and gracilis. True False b. The hypoglossal triangle (in the floor of the fourth ventricle) overlies the hypoglossal nucleus. True False c. The stria medullaris (in the floor of the fourth ventricle) forms the pontomedullary junction. True False d. The fibres of the dorsal columns of the spinal cord decussate as the decussation of the pyramids. True False e. The vestibulocochlear nerve lies ventral to the middle cerebellar peduncle. True False a. Anterograde amnesia is a common consequence of minor head injuries. True False b. Transient global amnesia involves an inability to form new memories. True False c. Concussion involves retrograde amnesia. True False d. The pathology of Alzheimer’s disease includes degenerative changes in the hippocampus. True False e. Korsakoff’s psychosis involves lesions of the thalamus caused by alcohol. True False 17. Within the medulla oblongata 18. Regarding memory disorders: Page 8 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 19. Regarding the corpus striatum and basal ganglia: a. The putamen and globus pallidus form the lentiform nucleus. True False b. The efferents of the globus pallidus mainly project to the thalamus. True False c. The posterior limb of the internal capsule separates the putamen from the head of the caudate nucleus. True False d. Afferent fibres to the putamen and caudate nucleus arise in the motor and premotor cortices. True False e. In Huntington’s chorea, abnormalities in the subthalamic nucleus give rise to the symptom of chorea. True False 20. Functional areas correctly matched with the appropriate anatomical area are: a. Primary motor cortex - anterior to the precentral gyrus True False b. Somatosensory association cortex - superior parietal lobule True False c. Primary auditory area - transverse temporal gyri within the superior temporal gyrus True False d. Receptive (Wernicke’s) language area - posterior aspect of the superior temporal gyrus True False e. Visual association cortex - within the calcarine sulcus True False a. GABAergic neurones play a role in generating the sleep spindles observed in the electroencephalogram. True False b. REM sleep is switched off by noradrenergic neurone activity. True False c. Caffeine is an adenosine receptor agonist. True False d. An orexin deficiency is present in narcolepsy. True False e. Acetylcholine agonists lead to EEG signs of arousal. True False 21. Identify the correct and the incorrect statement(s) Page 9 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 22. In the treatment of primary insomnia a. benzodiazepines increase the conduction of chloride ions across the neuronal cell membrane. True False b. first-generation antihistamines cause daytime sleepiness. True False c. non-benzodiazepines are selective for the α1 subunit of the GABAA receptor. True False d. melatonin antagonists increase total sleep time. True False e. sleep hygiene treatment includes daytime naps. True False 23. Identify the correct and the incorrect statements a. Prostaglandins lower the firing threshold for nociceptors. True False b. Allodynia is mediated by peripheral sensitization of touch receptors. True False c. Noradrenaline release in the dorsal horn inhibits transmission of nociceptive signals through the spinal cord. True False d. Nonsteroidal anti-inflammatory drugs (NSAIDs. are analgesic. True False e. Opioid-induced analgesia is mediated within the central nervous system. True False 24. Identify the correct and the incorrect statements a. Awareness requires a functioning cerebral cortex. True False b. Arousal is regulated by the reticular activation system. True False c. Patients in vegetative states have lower levels of awareness than do people who are fully conscious. True False d. Patients with locked-in syndrome have lower levels of awareness than do patients in vegetative states. True False e. Loss of brainstem reflexes is a sign of brain death. True False Page 10 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 25. Identify the correct and the incorrect statement(s) a. Declarative memories are encoded in the hippocampus. True False b. Procedural memory includes memories of events. True False c. The amount of information working memory is able to store increases as the complexity of the information increases. True False d. Activation of the amygdala facilitates memory encoding. True False e. The cerebellum encodes procedural memories. True False 26. A lesion of the left internal capsule may result in a. weakness of the lower half of the right side of the face. True False b. a reduced corneal reflex on the right. True False c. increased muscle reflexes in the right arm. True False d. deviation of the tongue to the left on protrusion.. True False e. a reduced consensual pupillary reflex when light is shone in the right eye True False 27. The neurotransmitter a. glycine has an excitatory effect on antagonist muscles. True False b. glutamate is synthesized from alpha-ketoglutarate. True False c. glutamate is excitatory at its ionotropic receptors. True False d. gamma amino butyric acid (GABA) is the major excitatory neurotransmitter in the cerebral cortex. True False e. GABA provides the major excitatory activity in the visual cortex. True False 28. The Babinski reflex a. is tested by applying a cold stimulus to the sole of the foot. True False b. is positive if the patient plantar flexes the foot. True False c. is positive in infants of six months of age. True False d. if positive in the adult, indicates corticospinal tract damage. True False e. if positive in the adult, indicates a lower motor neurone lesion. True False Page 11 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 29. During a rugby match a teenage boy (Fred Smith) sustained a serious injury in a scrum. He • • • was immediately admitted to hospital. On admission Fred was noted to have: Decreased motor function in both arms and both legs Decreased reflexes Decrease in all somatic sensory function. Based on the signs indicated above, it is evident that Fred had a. a transverse lesion of the lower thoracic spinal cord. True False b. a hemisection of the cervical spinal cord. True False c. bilateral lesions of his dorsal columns. True False d. bilateral lesions of his corticospinal tracts. True False e. spinal shock. True False 30. Two months later, after surgery to stabilize a fractured vertebra, Fred was discharged from hospital. On discharge Fred was noted to have: • Decreased facial sweating on the left side • A constricted pupil on the left side • Normal motor and sensory function in both his legs • Weakness and decreased sensation in his left hand Based on the signs indicated above, it is now evident that as a consequence of his injury, Fred had a. damaged his cervical ganglia on the left side. True False b. damaged the parasympathetic nerve supply to his face. True False c. damaged his cervical dorsal columns on the right. True False d. damaged his cervical corticospinal tracts on the right. True False e. Horner’s syndrome. True False 31. On discharge Fred complained of: • • Pins and needles in his left hand Pain in his neck and shoulder on the left The symptoms above described by Fred a. were due to damage to his cervical nerve roots on the left. True False b. could be treated with the administration of a serotonin reuptake inhibitor. True False c. were due to increased firing of the descending inhibitory pain pathways. True False d. were due to denervation hypersensitivity. True False e. were due to increased release of enkephalin neurotransmitters. True False Both were marked correct Page 12 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 32. Due to the weakness and altered sensation in his left hand, Fred’s mother always assisted him with fine motor tasks involving his hands such as opening bottles and jars. However, about 20 years after his injury, Fred noticed that his mother’s ability to perform these fine motor tasks which required strength had deteriorated. In addition, Mrs. Smith now needs glasses to read and frequently losses her balance. As a consequence of normal aging in Mrs. Smith a. the decrease in motor strength was due to loss of muscle fibres. True False b. the necessity to wear glasses for reading was due to the loss of accommodation for far distances. True False c. the necessity to wear glasses for reading was due to stiffening of the lenses in her eyes. True False d. the loss of balance was due to increased postural reflexes. True False e. the visual changes contributed to her loss of balance. True False 33. Reasons for students and clinicians avoiding involvement with the suffering in patients include a. “othering” where the clinician tries to magnify the faults in the patient to preserve their own purity True False b. Non Western concept of the need to conquer and control illness and suffering True False c. “Scientifise” the disease and lose the person behind the disease True False d. Fear of contamination with the suffering. True False e. Have not come to terms with their own suffering and with disease and death. True False 34. Drugs which stimulate dopamine receptors in the brain cause: a. extrapyramidal tremor True False b. vomiting True False c. postpartum lactation True False d. psychosis True False e. anhedonia (lack of pleasure in activities which were previously enjoyed) True False Page 13 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 35. The cornea: a. Is continuous with the sclera True False b. Maintains its clarity by means of an epithelial pump True False c. Is 1mm thick in the centre True False d. Derives its sensory nerve supply from the trigeminal nerve True False e. Has a good vascular supply True False a. Has 6 million rods mostly in the macula True False b. Uses cones for colour vision True False c. Is transparent True False d. Needs vitamins A, B and E for rhodopsin True False e. Derives all its blood supply from the central retinal artery True False a. Spread of infection from the middle ear can result in the development of a brain abscess True False b. Symptoms and signs of a brain abscess include fever, headache and focal neurological deficit True False c. In brain abscesses of bacterial aetiology, streptococci are infrequently isolated True False d. For a brain abscess <2.5cm in diameter, a combination of intravenous antibiotics and surgical therapy, is mandatory True False e. The presenting clinical features of a brain abscess are related to the size and location of the abscess True False a. Mental retardation is coded on axis I True False b. Inability to work is coded on axis II True False c. Asthma is coded on axis III True False d. Stress due to death of parents is coded on axis IV True False e. Major depression is coded on axis V True False 36. The retina: 37. Regarding brain abscesses: 38. With respect to the DSM-IV-TR multi-axial coding: Both correct Page 14 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 39. Poor prognostic features in Schizophrenia include: a. Gradual onset of negative symptoms True False b. Early age of onset True False c. High premorbid level of functioning True False d. Predominant positive symptoms with hallucinations and delusions True False e. Hostility, criticism and over-protectiveness within the family True False 40. Examples of negative symptoms of schizophrenia include: Lack of motivation True False b. Auditory hallucinations True False c. Thought disorder True False d. Social withdrawal True False e. Paranoid delusions True False a. 41. In terms of the Mental Health Care Act, No. 17 of 2002, a person may be admitted to hospital under the Act on involuntary basis in the following circumstances: a. if they have antisocial personality disorder True False b. psychotic with no insight, and are aggressive and refusing treatment True False c. incapable of making a decision about their treatment but do not refuse it True False d. homeless and neglected, but is not aggressive and does not refuse treatment True False e. The person has a history of alcohol use and has withdrawal symptoms with hallucinations True False 42. Maintenance treatment of Bipolar Mood Disorder includes: a. Lithium True False b. Phenytoin True False c. Lamotrigine True False d. Carbamazepine True False e. Sodium Valproate True False Option removed Page 15 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 43. Regarding children with disorders of learning: a. Anxiety disorders are frequently co-morbid True False b. A full developmental history is not necessary in their work-up True False c. Language disorders typically develop in adolescence True False d. Absence seizures may be mistaken for a learning disorder True False e. School drop-out rates are less than average True False 44. The following antiepileptic drugs enhance the effects of GABA: a. lamotrigine True False b. ethosuximide True False c. phenobarbitone True False d. diazepam True False e. carbamazepine True False 45. Antiepileptic drugs are correctly matched with other indications for which they are used: a. Carbamazepine - mood stabilisation True False b. topiramate - migraine prophylaxis True False c. levetiracetam - antiarrhythmic agent True False d. gabapentin - neuropathic pain True False e. ethosuximide - anaesthetic agent True False 46. Antiepileptic agents are correctly matched with the adverse effects which they cause: a. phenobarbitone - insomnia True False b. phenytoin - hirsuitism True False c. valproic acid - weight gain True False d. gabapentin - gingival hyperplasia True False e. lamotrigine - maculopapular rash True False Page 16 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 47. John Kennedy is a 37 year old male who is referred to you from his doctor who has been treating him for epilepsy for the past 3 years. The referring doctor says he would like you to help him to manage the patient as he is having recurrent episodes of strange behaviour including thrashing around and strange leg movement. Which of the following are true: a. An increased prolactin level may assist in the diagnosis True False b. The patient may be diagnosed by doing an EEG at the same time that you video the event(concurrent video-EEG monitoring) True False c. The patient is definitely not epileptic True False d. The patient may have frontal complex partial seizures True False e. The patient must be treated with an antipsychotic True False 48. R - Types A. B. C. D. E. F. G. H. I. J. Oculomotor nerve (CN III) Trochlear nerve (CN IV) Ophthalmic division of the trigeminal nerve (CN V1) Maxillary division of the trigeminal nerve (CN V2) Mandibular division of the trigeminal nerve (CN V3) Abducent nerve (CN VI) Facial nerve (CN VII) Glossopharyngeal nerve (CN IX) Vagus nerve (CN X) Hypoglossal nerve (CN XII) For each of the following clinical lesions identify the cranial nerve in the list above that is most likely to be involved. 48. Loss of sensation on the upper lip and cheek. A B C D E F G H I J F G H I J I J 49. Inability to close the eye. A B C D E 50. Inability to open the jaw against resistance. A B C D E F G H Page 17 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 49. John Brown is a 25 yr old lecturer who suffers from depression. He has recently returned home after spending two weeks in a psychiatric clinic for an episode of depression. From the options below select the BEST possible answer for each of the Statements. Answers may be used more than once. OPTIONS A. Discreditable condition B. Non maleficence C. Beneficence D. Discredited condition E. Felt stigma F. Patient autonomy G. Enacted stigma H. Patient-centredness I. Destigmatisation J. Stigma coach 51. At a follow up visit he says to his GP: “I feel fine …. But people at work are curious about why I have been away? I’ve never really looked depressed or sick, so what do I tell them? Do I tell them?” A B C D E F G H I J 52. Dr Naidoo says: “It’s understandable that you feel hesitant to disclose. What would you like to do? What are your concerns about disclosure?” A B C D E F G H I J 53. John says:”Oh you know how people are about mental illness. Rumours soon get around that you’re unstable especially when you’ve been in a psych clinic. I struggle quite a lot with this”. A B C D E F G H I J Page 18 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 50. A. Pain is subjective B. C. D. E. F. G. H. I. J. K. Painlessness is dangerous Pain sets the limits Pain needs interpretation Pain is a warning Pain is felt in the brain Pain is never imagined Placebo effect Distraction relieves pain Care and support relieve pain Understanding relieves pain From the list of concepts related to pain above, indicate which concept is best illustrated by each of the following quotes: 54. “A diagnosis gives our pain meaning, situates it in a context of cause and effect, and most importantly, in a context of action. When I know what my pain means, I know what I have to do – I know how to act responsibly.” (Scott Clark) A B C D E Option D and K are correct F G H I J K 55. “Pain is personal. It really belongs to the one feeling it. Probably the only thing that is your own.” (Henry Rollins) A B C D E F G H I J K 56. “Given the choice between the experience of pain and nothing, I would choose pain.” William Faulkner) A B C D E F G H I J K Page 19 of 19 SCMD 4000 - Block Examination 3, Neurosciences MCQ 2009 Group No: _________ Seat No: _____________ Student No: _________________ 51. A. B. C. D. E. F. G. H. I. J. phenytoin carbamazepine ethosuximide valproic acid lamotrigine topiramate phenobarbitone oxcarbazepine pregabalin levetiracetam 57. Lesedi is an 8 year old boy who has been diagnosed with absence seizures. He is started on medication and, although he takes the medicine exactly as instructed, 2 weeks later he has a tonic-clonic seizure. What is the most likely medication that was prescribed for the absence seizures? A B C D E F G H I J 58. From the given list of neuroprotective agents, this drug is prescribed in the management of neuropathic pain, but it does not undergo hepatic metabolism. A B C D E F G H I J 59. From the list above, this neuroprotective agent is used as an adjuvant in the drug management of weight loss. A B C D E F G H I J 60. Spina bifida occurs in 1-2% of exposures in the first month after fertilisation A B C D E F G H I J