ASCB AUGUST 2011 NEWSLETTER VOLUME NUMBER 7 Celldance Video Contest Kicks Off Seventh Big Year Talent Management in Academic Research Page 3 June MAC Programs and Events Page 11 Cell Biology in Canada Page 23 Inside President’s Column 34, 3 Dear Labby 7 Annual Meeting Program 8 Minorities Affairs 11 Online Job Board 14 Highlights from MBoC 16 Public Policy Briefing 18 WICB Column 19 iBioSeminars 22 Did You Know... ? 22 CLS Caucuses 22 International Affairs 23 Members in the News 25 Correction 25 2011 Half-Century Fund Donors 25 Calendar 25 In Memoriam 25 Members Gifts 25 Grants & Opportunities 26 Abstract Reviewers Wanted 26 “Celldance 2011” steps out in fake ballet shoes with mouse ballerina, “Black Schwann,” as the competition pirouettes into its seventh year. The world’s oldest cell biology film contest returns to its moving picture roots with cash prizes totaling $1,000 to be awarded to the best cell biology video and animated images. Opening the eyes of the world to the wonders of cell biology is the contest’s goal. Under the auspices of the ASCB’s Public Information Committee (PIC), the Celldance judges are looking for the best video, film, animation, or other moving image that illuminates the structure and function of cells. Entries can be descriptive or experimental, newly created video, or classic 8/16mm black and white films remastered on video. Animations, cartoons, and dynamic sequences from electron microscopy are welcome. (The Celldance still image competition has gone on sabbatical this year.) First prize will be $500 in cash plus complimentary registration for the 2011 Annual Meeting in Denver, CO, USA, December 3–7. All winners will be announced, and second and third place winners will also receive cash prizes. A special $250 “Celldance Public Outreach” award will also be presented in Denver. Celldance 2011 is supported by QImaging. For full details and the entry portal, go to www.ascb.org/meetings/celldance/index.cfm. Ideal for posting on your lab bulletin board, the 2011 Celldance “Black Schwann” poster (and all previous Celldance “movie” posters) can be downloaded for free from http://tinyurl.com/ CelldancePoster. The deadline for Celldance 2011 entries is September 27, 9:00 pm EDT. The Celldance Awards Presentation will be held on December 6, 2011, at the ASCB Annual Meeting in Denver. You must be an ASCB member or member applicant to enter. You don’t have to be present to win, although the adulation of your peers is not transferable. n —John Fleischman Are You Getting the Latest ASCB Member Benefit? You should now be regularly receiving our new biweekly email update, ASCB Pathways— alerting you to the latest ASCB happenings and 2011 Annual Meeting updates. If you aren’t seeing the e-newsletter in your inbox, please check your spam filter, and/or contact your system administrator to whitelist *ascb.org. n FEI Life Sciences The premier provider of 3D ultrastructural imaging solutions for the life sciences. The Tecnai Spirit TEM With the ease of a light microscope, The Tecnai™ Spirit TEM allows for the imaging of biological systems with the resolution needed to answer crucial biological questions. By automating 2D and 3D image acquisition, reconstruction, and visualization procedures, the Tecnai Spirit TEM ensures repeatable, high-quality results. Visit FEI.com/TecnaiSpirit for more information and a list of specific publications empowered by the Tecnai Spirit TEM. Free Life Sciences Webinars Learn about the latest tools for Life Science research and how FEI’s electron microscopy solutions are being used around the world. Current webinars: Bridging the Gap Between Light Microscopy and Electron Microscopy, High-throughput 3D Cellular Imaging, Cryo Transmission Electron Microscopy, and Introduction to Electron Microscopy in the Life Sciences. Visit FEI.com/Webinars for more information and to register. Negative stain preparation of rota virus. See Beyond at FEI.com/LifeSciences © 2009 FEI Company. Photo credit (left) sample courtesy of Cynthia Goldsmith, Center for Disease Control, Altanta, USA. Photo credit (right) sample courtesy of Dr. Wayne Moore and Ms. Susan Shinn, University of British Columbia, Vancouver, Canada. Nerve bioposy from a patient with a peripheral neuropathy. PRESIDENT’S Column Sink or Swim: Talent Management in Academic Research As a graduate student Jane was among the top of her class. Thankfully, she had a creative and conscientious advisor who assigned her a great project—other students in her department were not so lucky. Jane worked hard to generate lots of interesting data, and together with her advisor wrote and published several papers. This early success made her competitive for a prestigious postdoctoral fellowship and hence an independently funded position in a large, big-name lab at a toptier research university. As a postdoc, Jane needed to establish her independence and to identify a project that she could take with her. Thus, after she made a serendipitous discovery, she began to work independently. Jane was Sandra Schmid ambitious and in a hurry to get a “real” job and to run her own lab. So she focused on her own work and didn’t interact much with others in the lab. In fact, Jane was afraid that other postdocs, lost in a large group and largely neglected by a busy PI, might jump on her project; so she avoided sharing her ideas, even with her advisor. Jane published a single, high-impact paper and successfully landed a coveted tenure-track assistant professorship at a prestigious medical school (PMS). Getting Started As a “hot,” new assistant professor, Jane was given a million dollar start-up package and 1,500 square feet of empty lab space. For the first year, she could focus on equipping and setting up her lab, hiring a technician, recruiting a postdoc, and starting her own research program. New graduate students, who are attracted by shiny new equipment and a young and enthusiastic faculty member, line up to do rotation projects in her lab. However, in Jane’s second year, just as her new student and postdoc are starting, she would need to prepare and give lectures to the medical students twice a week. She would also need to begin participating in department committees. She would have to write grants that would provide operating AUGUST 2011 ASCB NEWSLETTER expenses for the lab, and salary support for her students, postdocs, and technician. Eventually she would also be expected to support at least half of her salary. At her current burn rate, the “generous” start-up package would be depleted in less than three years. Lastly, Jane’s five-year tenure clock starts ticking the moment she enters her new lab. Very little Jane learned as a graduate student or postdoc had prepared her to run a small business, be a fundraising entrepreneur, manage a budget, hire and train employees, negotiate with journal editors, or teach. Certainly, there had been no formal training in any of these areas. Similarly, there were no classes in lab or conflict management, leadership, or finance offered at her PMS: few how-to books have been written. Jane’s department chair is a nice guy, but he’s very busy running his own lab and writing his own grants and papers, and he travels a great deal. Jane hardly sees him and, when she does, he only wants to talk about her or his latest experiment. She has been assigned a faculty mentor, but this senior colleague is also very busy, and she feels uncomfortable imposing on his time. What’s Wrong with This Picture? Embedded in this, albeit slightly exaggerated, description of the current process for training, recruitment, promotion, and tenure (i.e., what businesspeople call talent management) in the world of academic research are several areas which, when viewed from the perspective of the “real” world, seem flawed or even nonsensical. Is there a better way? One-Size-Fits-All Graduate Student/ Postdoc Training Graduate student/postdoc training at major research institutions is still largely geared toward a single career path, i.e., to be an experimentalist and conduct independent research. Yet, U.S. statistics show that we train many more PhD graduate students than there are ultimately The American Society for Cell Biology 8120 Woodmont Avenue, Suite 750 Bethesda, MD 20814-2762, USA Tel: 301-347-9300 Fax: 301-347-9310 ascbinfo@ascb.org, www.ascb.org Joan R. Goldberg Executive Director Officers Sandra L. Schmid President Ronald Vale President-Elect Timothy J. Mitchison Past President Thoru Pederson Treasurer Jean E. Schwarzbauer Secretary Council David Botstein Raymond J. Deshaies Joan R. Goldberg, ex officio Akihiro Kusumi Inke Näthke James H. Sabry David L. Spector Elizabeth Sztul JoAnn Trejo Fiona M. Watt Susan M. Wick Virginia A. Zakian Yixian Zheng The ASCB Newsletter is published 11 times per year by The American Society for Cell Biology. Joan R. Goldberg Editor W. Mark Leader Editor Elizabeth M. Rich Production Manager Kevin Wilson Public Policy Director John Fleischman Science Writer Thea Clarke Editorial Manager Advertising The deadline for advertising is the first day of the month preceding the cover date. For information contact Advertising Manager Ed Newman, enewman@ascb.org. ASCB Newsletter ISSN 1060-8982 Volume 34, Number 7 August 2011 © 2011 The American Society for Cell Biology. Copyright to the articles is held by the author or, for staff-written articles, by the ASCB. The content of the ASCB Newsletter is available to the public under an Attribution-Noncommercial-Share Alike Unported Creative Commons License (http://creativecommons.org/licenses/ by-nc-sa/3.0). Postmaster: Send change of address to: ASCB Newsletter The American Society for Cell Biology 8120 Woodmont Avenue, Suite 750 Bethesda, MD 20814-2762, USA 3 When was the last time you talked to your trainees about long-term strategies and decisionmaking; about how to look at your data, formulate questions, and generate a testable hypothesis; about the sources of innovation? … good teachers can more quickly bring these skills to fruition. 4 imagine how much more effective corporations positions for. According to a study by the U.S. and government would be if more scientifically National Academy of Sciences,1 61% of life scientists who received their PhDs in 1963–64 trained, critically thinking professionals were eventually acquired tenured faculty positions. in leadership roles. Yet we expect our graduate This number dropped to students to focus on and 54% for the 1971–72 cohort become experts in a single and 38% for the 1985–86 area of research, and to make …we expect our cohort. Even when academe, an independent, high-impact graduate students government, and industry discovery. Fulfilling these latter to focus on and are combined, the respective expectations, which often takes fractions of PhDs in permanent six years or more, is important become experts U.S. research positions declined if one is to pursue an academic in a single area from 89% of 1975 graduates career. But it may even be to 61% of 1995 graduates. counterindicative for success in of research, And it continues to decline. other arenas. Moreover, smart and to make an The consequence is a logjam and talented PhD students before the constriction point slow to fulfill these expectations independent, highof permanent employment. become discouraged and lose the impact discovery. Young scientists pile up in lowself-confidence they should have paying postdoc positions, which Fulfilling these latter as potential leaders in society. provide neither retirement expectations… benefits nor long-term security. Training for Success may even be The morale and, therefore, While we provide ample motivation levels among opportunities for discovery, too counterindicative postdocs stuck in this holding few of us as mentors explicitly for success in pattern can be low. Jane’s hard train our students and postdocs work, ambition, and luck for success. We give our students other arenas. allowed her to be hired into a the “freedom” to learn from tenure-track position by age their mistakes. We think that, 33. Today, the average new American assistant as Efraim Racker famously said, “Troubles are professor will be closer to 40. good for you.” One often hears advisors proudly This situation is discouraging many bright recalling that their students fumbled around for young undergraduates from pursuing careers a few years learning from their own mistakes and in academic science. It is also preventing then suddenly “got it” before proceeding more diversification of our academic ranks. linearly to completion of their thesis research. Economically disadvantaged minorities and Perhaps we could increase the efficiency and others might understandably think twice effectiveness of this training if we were more about the time commitment (more than 10 directive and more explicit and by helping our years postgraduate) and hurdles that must be students learn from the mistakes we have already overcome before the possibility of permanent made. When was the last time you talked to your employment. Because this holding pattern trainees about long-term strategies and decisionoccurs during prime childbirth years, women are making; about how to look at your data, formulate also more likely to seek alternate careers. questions, and generate a testable hypothesis; Equally troubling, the system of one-sizeabout the sources of innovation? While some of fits-all training wastes talent. As recent college these abilities are innate, I believe good teachers graduates, entering PhD students are among the can more quickly bring these skills to fruition. most educated, highest-potential young adults We also do not train our students/postdocs to in society. Further education in the scientific be effective lab managers. Typically, a new faculty method, in critical thinking, in research and member will no longer be performing his or her communication, only serves to increase the own bench work within approximately three recipients’ potential value to society. Such training years of appointment. In well-run businesses, the provides transferable skills that would ensure highest-potential employees are typically required students’ success in whatever occupation matches to partake in management and leadership their innate talents and passions. I can’t help but classes, because they are aware that “the greatest ASCB NEWSLETTER AUGUST 2011 transition of all—from doing the work to seeing that it is done by others, from being motivated to motivating others, from being developed to developing others, from managing our work to managing the work of a unit, from working to delegating,”2 is also the most difficult. Yet, in academic research, we hire assistant professors and then set them loose to run a lab without any previous experience or training. The consequences of this sink-or-swim mentality are: 1) unnecessary and preventable failures, 2) perpetuation of poor practices of lab management, 3) re-inventing the wheel, by repeating others’ mistakes until stumbling onto formulas that work, and 4) inefficient training, lower motivation, and, consequently, reduced productivity of lab personnel. More directed training could eliminate or at least reduce each of these consequences. Winds of Change The U.S. National Institute of General Medical Sciences has recently published a strategic plan for biomedical research training,3 which repeats many of the conclusions and objectives of a U.S. National Academies study on graduate education published in 1994.4 Why has progress been so slow? In part, it is because established investigators continue to train their students the way they were trained. They have no other models and, after all, it worked for them. One suggestion is for PhD programs to collaborate with business schools to create courses on management and leadership skills that are applicable not only in the laboratory but in any career. I would also suggest that graduate students begin to focus more on their specific and individual career objectives, to think more broadly about how they can apply their skills, and to identify what they are passionate about. Individual development plans (IDPs) are available from numerous sites on the Web to serve as templates. Students must share this vision for their career objectives with their advisors and committees to create an IDP and expectations commensurate with that vision. One ought to be able to obtain the training and transferable skills needed to succeed in virtually all endeavors in four years. The singular discovery and demonstrating the persistence to see it through could, depending on luck, take longer. However, although accomplishing this research objective may be a necessary prerequisite for a research scientist, it is not a prerequisite for success in AUGUST 2011 ASCB NEWSLETTER the many other worthy endeavors toward which individuals can apply their PhD experience. Certainly in most European countries, four years is the maximum for completing a PhD, and our European colleagues are making significant contributions in science and other important arenas. Given today’s realities, we need to help all of our graduate students and postdocs, who constitute an incredible pool of young talent, achieve success. Epilogue Jane submits and receives her first R01, aided in part by the clear mandate of the U.S. National Institutes of Health to fund early investigators. Although stumbling at the outset, her first graduate student publishes two excellent papers in Molecular Biology of the Cell (MBoC ), successfully defends his thesis, and begins a career as a science technology writer. Her first postdoc co-authors the MBoC papers and takes a position as an AP Biology teacher at a local private high school. Although she runs a small lab, Jane continues to make creative contributions in the research area she’s passionate about, thanks in part to interdisciplinary collaborations with her colleagues at her PMS. She is on a path toward tenure. Mostly, despite the pressures and problems, she loves her job and the excitement of discovery. And she helps her students and postdocs to achieve their goals too. n I would also suggest that graduate students begin to focus more on their specific and individual career objectives, to think more broadly about how they can apply their skills, and to identify what they are passionate about. Comments are welcome and should be sent to president@ascb.org. References National Academy of Sciences, National Research Council. (1998). Trends in Early Careers of Life Scientists. Report of the Committee on Dimensions, Causes, and Implications of Recent Trends in Careers of Life Scientists. http://books.nap.edu/catalog. php?record_id=6244. 1 Lombardo MM, Eichinger RW (2006). The Leadership Machine: Architecture to Develop Leaders for Any Future, 3rd Ed., Lominger International: A Korn/Ferry Company, p. 31. 2 Investing in the Future: NIGMS Strategic Plan for Biomedical and Behavioral Research Training. http:// publications.nigms.nih.gov/trainingstrategicplan/ Strategic_Training_Plan.pdf. 3 National Academy of Sciences, National Academy of Engineers, Institute of Medicine. (1994). Reshaping the Graduate Education of Scientists and Engineers. www. nap.edu/catalog.php?record_id=4935. 4 5 © Leica Microsystems, Inc. 07/2011 BNA#630 Starting a New Lab? Leica Microsystems’ New Investigator Program can save you thousands! If you are starting up a new lab or beginning a new research project, contact your Leica Microsystems representative to learn about our New Investigator Program. You can qualify for thousands in discounts on live cell and fluorescence microscopes, stereomicroscopes, digital cameras, imaging software, and more . . . Visit www.leica-microsystems.com/newresearch for more information. Living up to Life DEAR Labby Do I Have a Conflict of Interest? Dear Labby, I have the sense that your column is for students and postdocs, i.e., career development stuff, so I never thought I would be writing, but have been encouraged to do so. I am a professor of cell biology at a state university medical school in the Midwest. I’ll be brief. Two years ago I made an invention and started a company. My institution supported the patent filing and licensing to the start-up but did nothing else. Meanwhile, I scrambled around like a prairie dog on speed and got things going. My university has a consulting rule: one day a week. That was not going to work so I asked for, and got, permission to serve as the company’s interim CEO at 50% effort. A year later my Dean now says the part-time CEO position is over and I have to decide—company full-time or back to the university full-time. I say baloney. If I continue as interim CEO the chances that the company will make money for the university increase. What am I missing in this picture? I have talked to some business people and lawyers, but this whole thing seems to come down to my university’s conflicts of interest policy. I am told I signed some invention agreement when I took this job. Just the other day a graduate student down the hall, who heard me complaining, said, “Ask Labby.” I am an ASCB member so I have seen your column. I told the student that Labby was not likely to know anything about my problem. But she did not relent, saying, “Just try her.” So here I am with my case. —Split Dear Split, Not knowing the conflicts of interest policy of your institution—or the details of the invention agreement you signed—Labby can only offer some general principles that are in play across the land. The invention agreement you mentioned is called an assignment of rights. It means for employment you assigned your intellectual property rights to the university. This is standard and you get something back—an allocation of patent-related income. The one-day-per-week consulting policy is intended to allow faculty to pursue advisory roles in keeping with the academic tradition (we are called professors because we have something to profess). If our knowledge as scholars can help people, improve the quality of life, save Earth from destruction, why not? A general policy that has evolved is that a faculty member should not serve as an officer of a company indefinitely, and most institutions have put a time limit on this. One reason is that such a split allegiance inevitably shifts to the company’s favor with time, catalyzed in part by financial incentives of founder’s stock or stock options. A second factor is that a university has the legal right, as the employer, to require that a faculty member not be unduly distracted from fulfilling contractual terms of the job description. The one day/week consulting policy in wide use is intended to recognize the value of a degree of entrepreneurial effort by faculty members. But the fact that these policies are not more liberal (two days or more) is based on the notion that the primary duty of the faculty member is to the institution. This is a particularly enabling feature of such policies at state universities, such as yours, at which the taxpayers’ perspective expects professors to primarily serve the university. As regards your specific issue, there is among many universities a policy (often unwritten) that allowing a faculty member to sit 50:50 in both worlds is unhealthy. At Labby’s institution we have a case such as yours; the faculty member and the university have reached the constructive agreement (in this case) that her first love is the company. So after a year of the same 50:50 effort you have been doing, she will join her company full-time. A final point you may want to consider is that biotech companies that have started out with a scientist CEO have often done poorly. The critical need here is to get a business-based CEO lined up with whom your university can work. n —Labby Direct your questions to labby@ascb.org. Authors of questions chosen for publication may indicate whether or not they wish to be identified. Submissions may be edited for space and style. Got Questions? Labby has answers. ASCB’s popular columnist will select career-related questions for publication and thoughtful response in the ASCB Newsletter. Confidentiality guaranteed if requested. Write us at labby@ascb.org. n AUGUST 2011 ASCB NEWSLETTER 7 THE AMERICAN SOCIETY FOR CELL BIOLOGY December 3–7, 2011 l Sandra Schmid, President l Jan Ellenberg, Program Chair Symposia • Consecutive sessions showcase increasing complexity. Molecular Mechanisms Sunday, December 4, 8:00 am–9:30 am Member-organized Special Interest Subgroups Saturday, December 3 12:30 pm–5:00 pm Session titles, organizers, and speakers to be announced in the fall Jennifer A. Doudna, University of California, Berkeley/HHMI Judith Frydman, Stanford University Thomas Surrey, Cancer Research UK London Research Institute Function of Multi-Molecular Machines Sunday, December 4, 10:30 am–12:00 pm Raymond Deshaies, California Institute of Technology/HHMI Melissa Moore, University of Massachusetts Medical School/HHMI David Drubin, University of California, Berkeley Cellular Networks and Information Processing Monday, December 5, 8:00 am–9:30 am KEYNOTE SYMPOSIUM Saturday December 3 Molecules and Systems: Our Quest for a Physiology of the Cell Michael Elowitz, California Institute of Technology/ HHMI Christine Jacobs-Wagner, Yale University/HHMI Chris Marshall, Institute of Cancer Research, London, UK Self-Organization of Cellular Structures Monday, December 5, 10:30 am–12:00 pm Gaudenz Danuser, Harvard Medical School Benjamin Glick, University of Chicago Francois Nedelec, European Molecular Biology Laboratory, Heidelberg, Germany Minisymposia • Stimulating, interactive sessions, December 4–6, 4:30 pm–6:35 pm, and December 7, 8:30 am–10:35 am • Additional presentations selected from abstracts Actin Dynamics Marie-France Carlier, French National Center for Scientific Research (CNRS), Gif-sur-Yvette, France Rong Li, Stowers Institute for Medical Research Bioengineering and Mechanobiology Adam J. Engler, University of California, San Diego Celeste Nelson, Princeton University Cancer Cell Biology Franziska Michor, Dana-Farber Cancer Institute Michael Yaffe, Massachusetts Institute of Technology Cell Biology of Micro-Organisms and the Evolution of the Eukaryotic Cell Sean Crosson, The University of Chicago Joel B. Dacks, University of Alberta, Canada Cell Biology of RNA Xavier Darzacq, Ecole Normale Superieure, France Leemor Joshua-Tor, Cold Spring Harbor Laboratory/ HHMI Cell Cycle Dynamics and Checkpoints Frederick Cross, The Rockefeller University Silke Hauf, Friedrich Miescher Laboratory of the Max Planck Society, Germany Complex Cellular Functions: Linking Networks and Structures Tuesday, December 6, 8:00 am–9:30 am Kristin Baldwin, The Scripps Research Institute William Bement, The University of Wisconsin– Madison W. James Nelson, Stanford University Mechanism of Multicellular Functions Tuesday, December 6, 10:30 am–12:00 pm Marc Kirschner Harvard Medical School Darren Gilmour, European Molecular Biology Laboratory, Heidelberg, Germany Arthur Lander, University of California, Irvine Jennifer A. Zallen, Sloan-Kettering Institute/HHMI Design Principles of Cells and Tissues Wednesday, December 7, 11:00 am–12:15 pm Linda Griffith, Massachusetts Institute of Technology Wallace Marshall, University of California, San Francisco Cell Migration Diane Barber, University of California, San Francisco Alex Mogilner, University of California, Davis Cell Polarity Thomas Lecuit, Institut de Biologie du Développement de Marseille-Luminy (IBDML), France Lesilee Rose, University of California, Davis Cell-Cell and Cell-Matrix Interactions Josephine Adams, University of Bristol, UK Kris DeMali, University of Iowa 8 ASCB NEWSLETTER AUGUST 2011 Complete details at www.ascb.org/meetings Cell-Pathogen Interactions (Viruses and Bacteria) Nihal Altan-Bonnet, Rutgers University Olivia Steele-Mortimer, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH Cellular Functions of Ubiquitin and Ubrelated Proteins Claudio Joazeiro, The Scripps Research Institute Frauke Melchior, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Germany Mitosis Tarun Kapoor, The Rockefeller University Béla Novák, University of Oxford, UK Modeling and Simulation of Cellular Functions Hana El-Samad, University of California, San Francisco Ewa Paluch, Max Planck Institute of Molecular Cell Biology, Dresden, Germany Motors and Microtubule Dynamics Jonathon (Joe) Howard, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany Patricia Wadsworth, University of Massachusetts Nuclear Organization and Control of Gene Expression Orna Cohen-Fix, National Institute of Diabetes and Digestive and Kidney Diseases, NIH Yaron Shav-Tal, Bar-Ilan University, Israel Organelle Biogenesis and Autophagy Cellular Mechanism of Disease and Aging Craig Blackstone, National Institute of Neurological Disorders and Stroke, NIH Coleen Murphy, Princeton University Chemical Biology: Probes and Therapeutics Lisa Belmont, Genentech, Inc. Alice Ting, Massachusetts Institute of Technology Chromosome Structure and Epigenetics Sue Biggins, Fred Hutchinson Cancer Research Center Job Dekker, University of Massachusetts School of Medicine Cilia and Centrosomes Anne Simonsen, University of Oslo, Norway Gia Voeltz, University of Colorado at Boulder Signal Transduction Networks Philippe Bastiaens, Max Planck Institute of Molecular Physiology, Germany Wendell Lim, University of California, San Francisco/ HHMI Federica Brandizzi, Michigan State University Rainer Pepperkok, European Molecular Biology Laboratory, Heidelberg, Germany Meiosis and Oogenesis Laurinda A. Jaffe, University of Connecticut Health Center Marie Verlhac, Centre for Interdisciplinary Research in Biology, CNRS/INSERM, Collège de France, Paris, France Membrane Fission and Fusion Marko Kaksonen, European Molecular Biology Laboratory, Heidelberg, Germany Alex Merz, University of Washington School of Medicine AUGUST 2011 ASCB NEWSLETTER October 13 Late Abstracts (for poster consideration only) Pamela Silver, Harvard Medical School Ron Weiss, Massachusetts Institute of Technology Working Groups Intracellular Sorting and Trafficking October 3 Discounted Early Registration Synthetic Cell Biology Collective Cell Behavior and Morphogenesis in Development Caroline Kane, University of California, Berkeley Susan Wick, University of Minnesota DEADLINES September 1 Regular Abstract Submission (for poster consideration only) Fernando Camargo, Children’s Hospital Boston and Harvard University Leanne Jones, Salk Institute for Biological Studies The Nuclear Periphery Innovations in Cell Biology Graduate Education Meeting registration, abstract submission, and hotel reservations are now available at www.ascb. meetings/meetings. Stem Cells and Pluripotency Ingrid Hoffmann, German Cancer Research Center (DKFZ), Germany Meng-Fu Bryan Tsou, Memorial Sloan Kettering Cancer Center Ryoichiro Kageyama, Kyoto University Denise Montell, Johns Hopkins University School of Medicine IMPORTANT DATES Brian Burke, Institute of Medical Biology, Singapore Valérie Doye, Institute Jacques Monod, France • Interactive “town hall” for “big questions,” December 4–6, 4:30 pm–6:35 pm, and December 7, 8:30 am–10:35 am • Co-chairs present and select speakers Using Large Data Sets as Tools to Understand Cell Biology Lani Wu, University of Texas Southwestern Medical Center Wolfgang Huber, European Molecular Biology Laboratory, Heidelberg, Germany Learning from Heterogeneity and Stochastic Cell Behavior Johan Paulsson, Harvard Medical School Lucas Pelkmans, Swiss Federal Institute of Technology Zurich (ETH) Imaging Cellular Structure across Scales John Briggs, European Molecular Biology Laboratory, Heidelberg, Germany Melike Lakadamyali, Institute of Photonic Sciences (ICFO), Spain 9 Minorities Affairs MAC Busy in June! Hosting its annual workshop, conducting its summer meeting, and running several programs— the ASCB Minorities Affairs Committee (MAC) was quite busy in June. MAC Chair Renato Aguilera stated, “Yes, the MAC is busy in the summer!” The MAC is committed to furthering career development for minority students and early-career scientists. Please see highlights below on these programs/meeting: n MAC Summer Meeting n MAC Mentoring Program (New) n MAC Sixth Annual Junior Faculty and Postdoctoral Fellows Career Development Workshop n Linkage Fellows n Visiting Professors n Marine Biological Laboratory Students n Friday Harbor Laboratories Students MAC Summer Meeting Ongoing activities and grant financial management were the focus of the MAC annual summer meeting, held this year in Atlanta, GA, on June 12. The Committee, under the leadership of Chair Renato Aguilera, discussed programs funded by a U.S. National Institutes of Health/National Institute of General Medical Sciences Minority Access to Research Careers (NIH/NIGMS/MARC) grant. The MAC discussed all of its programs and agreed that the MAC has to focus more on marketing and advertising its programs during the next fiscal year. “MAC program evaluations for the past few years have been outstanding,” reported MARC Grant PI David Burgess. This shows that MAC programming is fulfilling the grant’s goals. MAC ASCB Annual Meeting programs were discussed as the MAC gears up for the ASCB Annual Meeting in December. The MAC is expecting a great program, at least 100 travel awardees, and excellent evaluations! MAC Chair Renato Aguilera at the Career Development Workshop Participants Selected for ASCB MAC Mentoring Program Two junior scientists were selected to participate in the MAC’s new Mentoring Program. Tama Hasson, MAC Mentoring Program Subcommittee Chair, stated, “I am pleased that the program is under way as it has long been in the planning stages; and I am happy to announce that both mentees and mentors have been selected for our first application cycle.” The objective of this program is to assist newly independent investigators from groups underrepresented in the sciences as they write their first research grant. This program includes $1,000 funding for travel for the mentee to visit the mentor’s institution. Minority professors and professors in colleges and universities with a high minority enrollment are especially encouraged to apply for this program. Participants selected and their mentees are listed below: n Mentee: Joaquin N. Lugo, Baylor University Mentor: Thoru Pederson, University of Massachusetts Medical School n Mentee: Carlita Favero, Ursinus College Mentor: Anthony DePass, Long Island University The MAC would like to thank the mentors for volunteering their time to mentor! The ASCB MAC Mentoring Program is supported by an NIH/NIGMS/MARC grant. For more information on this program, please visit the ASCB website at www.ascb.org and click on “Committees,” then “Minorities Affairs.” The application deadlines are September 15, 2011, and April 15, 2012. AUGUST 2011 ASCB NEWSLETTER 11 MAC Sixth Annual Junior Faculty and Postdoctoral Fellows Career Development Workshop “I think this is the best workshop ever,” stated Aguilera. MAC’s Sixth Annual Junior Faculty and Postdoctoral Fellows Career Development Workshop, designed to provide information on publications, grant writing, mentoring, time management, professional development, lab management, and other topics critical for junior faculty and postdoctoral fellows, was held in Atlanta, GA, June 10–11, 2011. There were 24 attendees. Based on evaluations, the Junior Faculty and Postdoctoral Fellows Career Development Workshop is one of the MAC’s finest programs. Speakers and planners this year included Aguilera, Professor and Director of the Graduate Program in Biology, University of Texas, El Paso; Burgess, Professor of Biology, Boston College; Andrew Campbell, MAC member and Associate Professor of Medical Science, Brown University; Franklin Carrero- Martinez, MAC member and Assistant Professor, University of Puerto Rico, Mayaguez; Anthony D. Carter, Program Director, Division of Genetics & Developmental Biology, NIGMS, NIH; Deborah Harmon Hines, MAC member and Vice Provost and Professor, University of Massachusetts Medical School; Michael Leibowitz, MAC member and Executive Director of Graduate Academic Diversity, University of Medicine and Dentistry, New Jersey Graduate School of Biomedical Sciences; Veronica Lopez, MAC member and Research Assistant, The Pennsylvania State University; Sandra Murray, MAC member and Professor, University of Pittsburgh School of Medicine; Richard Rodewald, Program Director for Cellular Processes Cluster, U.S. National Science Foundation; and MariaElena Zavala, MAC member and Professor of Biology, California State University, Northridge. Attendees, speakers, and staff at the ASCB MAC Sixth Annual Junior Faculty and Postdoctoral Fellows Career Development Workshop in Atlanta, GA Workshop attendees participated in group discussions throughout the two-day workshop. 12 ASCB NEWSLETTER AUGUST 2011 What Some Attendees Thought about the MAC Workshop Raphyel Rosby “The ASCB MAC 6th Annual Junior Faculty and Postdoctoral Fellows Career Development Workshop was excellent in every aspect. I assumed there would be some things that I would know already. However, even when presenting information that I was familiar with, the presenters often gave alternative approaches that I found extremely useful. The workshop gave insight into aspects of getting a faculty job and the tenure process that I had never heard. The networking opportunities were very helpful in that the group had a focused interest. In the end, I am very glad that I was able to attend, and have already recommended it to several of my peers.” —Raphyel Rosby, Postdoctoral Research Associate, Brown University “As a result of attending this workshop, I am better prepared to successfully transition into a junior faculty position. Not only am I better informed about the challenges involved in joining the professoriate and attaining tenure, but I now have access to strategies and advice to tackle them. Furthermore, when a difficulty arises that I do not know how to overcome, I now have new contacts and colleagues who are willing and able to provide good advice and support.” —Veronica A. Segarra, Postdoctoral Fellow, University of Miami Nelson NunezRodriguez Veronica A. Segarra “The 2011 MAC workshop provided me an opportunity to reinforce my professional priorities by sharing experiences with minority faculty from other institutions. It was a mentoring experience providing useful tools to manage the daunting task of devising teaching, research, and service duties in my teaching-intensive institution. Overall, this workshop has empowered my commitment to integrate scholarship work with my teaching duties. I look forward to participating in future MAC opportunities.” —Nelson Nunez-Rodriguez, ASCB MAC Linkage Fellow, Hostos Community College, CUNY MAC Linkage Fellows Selected The MAC is pleased to announce that 10 scientists have been selected to serve as Linkage Fellows for 2011. Funding for this program is provided for Fellows to support outreach and activities that promote cell biology at their home institutions. The major goal of this program is to increase participation of faculty from minorityserving institutions to “serve as a link” between the institution, its students, faculty, administration, and the ASCB MAC. The Linkage Fellows Program is supported by an NIH/NIGMS/MARC grant. The Linkage Fellows Program acknowledges all past Fellows as alumni/ alumnae. Alumni/alumnae are encouraged to remain in the MAC community and continue to serve as that important link between their institutions and the MAC. Alumni/alumnae are also eligible to apply for MAC Travel Awards to the ASCB Annual Meeting. AUGUST 2011 ASCB NEWSLETTER The 10 scientists selected for 2011 funding are: Manuel A. Barbieri, Florida International University n Tracie Gibson, University of Texas of the Permian Basin n Triscia Wharton Hendrickson, Morehouse College n Lalitha Jayant, Borough of Manhattan Community College n Patrick Martin, North Carolina A&T State University n Fran Norflus, Clayton State University n Nelson J. Nunez-Rodriguez, Hostos Community College, CUNY n Janet Rollins, College of Mount Saint Vincent n Oluseyi A. Vanderpuye, Albany State University n Velinda Woriax, University of North Carolina, Pembroke Applications for the 2012 MAC Linkage Fellows Program will be available on the ASCB website in January 2012. n 13 MAC Summer Visiting Professorship Awardees Selected MAC Awardees Supported at Marine Biological and Friday Harbor Laboratories The MAC is pleased to sponsor six scientists for collaborative research with host scientists this summer. The MAC Visiting Professors program is supported by an NIH/NIGMS/MARC grant. The program’s major purpose is to provide research support for professors at minority-serving institutions to work in the laboratories of members of the ASCB for an eight- to 10-week period during the summer. The six 2011 Visiting Professors and their Host Scientists are listed below: n Visiting Scientist: Oluwole Ariyo, Allen University (2nd year) Host Scientist: Lewis Bowman, University of South Carolina n Visiting Scientist: Jacqueline Jordan, Clayton State University (2nd year) Host Scientist: Gary Miller, Emory University n Visiting Scientist: Kenneth Ndebele, Jackson State University (2nd year) Host Scientist: Roya Khosravi-Far, Harvard Medical School n Visiting Scientist: Thomas Onorato, LaGuardia Community College/CUNY (2nd year) Host Scientist: Gary M. Wessel, Brown University n Visiting Scientist: Teresa Shakespeare, Fort Valley State University (1st year) Host Scientist: Sandra Murray, University of Pittsburgh School of Medicine n Visiting Scientist: Caroline Telles, Southern University and A&M College (1st year) Host Scientist: M. Mitchell Smith, University of Virginia Health System Applications for the 2012 MAC Visiting Professors Program will be available on the ASCB website in January 2012. Supporting participants in programs at the Marine Biological (MBL) and Friday Harbor Laboratories (FHL) is an important aim of the ASCB MAC. The MAC works with the MBL and FHL to strengthen the training of underrepresented minorities and provide valuable networking opportunities. These opportunities frequently translate into future professional opportunities, including postdoctoral fellowships, career positions, and scientific collaborations. The MAC MBL and FHL programs are supported by an NIH/NIGMS/MARC grant. The 12 students selected for funding in 2011 are: Marine Biological Laboratory n Evan Archer, University of Texas-Austin (Methods in Computational Neuroscience) n Oscar Cabrera, Florida State University College of Medicine (Physiology) n Victor Cazares, University of Michigan (Neurobiology) n Sindy Chaves, University of Nevada, Reno (Molecular Mycology) n Bianca Jones, New York University School of Medicine (Neural Systems and Behavior) n Aracely Lutes, University of Kansas Medical Center (Embryology) n Mitra Miri, Yale University School of Medicine (Neural Systems and Behavior) n William Munoz-Miranda, New York University School of Medicine (Neural Systems and Behavior) n Valerie Virta, National Institute of Child Health and Human Development, NIH (Embryology) n David Vuono, Colorado School of Mines (Microbial Diversity) Friday Harbor Laboratories n Kristin Andrykovich, Carleton College (Genomics) n Paul Hausch, Ripon College (Genomics) n —Deborah McCall ASCB Highlights Positions: Have One To Fill? Want One? Did you know that the ASCB Online Job Board offers a variety of options for those recruiting or seeking postdoctoral fellowships and academic and industry positions? You don’t have to be an ASCB member to take advantage of these opportunities, but ASCB members do enjoy significant discounts. Visit the ASCB Online Job Board at http://jobboard.ascb.org. For Job-Seekers n n n Post your résumé/CV at no charge, search job announcements, apply for jobs listed, and receive email alerts when jobs matching your criteria are posted. Currently, 304 active CVs/résumés are available for viewing. In 2011, the ASCB job postings have received 13,818 page views to date. For Employers Post your position and receive emails daily with qualified candidates. n Increase your exposure with Featured Job and Featured Employer options. n Receive a 50% discount for job postings if you’re an ASCB member. Write careers@ascb.org if you have any questions. Consider expanding your search with ads in the ASCB Newsletter. Contact enewman@ascb.org. n n 14 ASCB NEWSLETTER AUGUST 2011 Growth Confocal © Leica Microsystems, Inc. 09/2010 BNA#626 Room to Grow Get Started with Confocal ... with an Entry-level Budget! The Leica TCS SP5 II Growth Confocal imaging system for entry-level budgets offers high sensitivity and superb resolution, plus it is fully upgradable as your research demands grow. The growth possibilities are endless: add options for deep tissue imaging, high-speed cellular dynamics, and even super-resolution. Save more as you add features, functionality, service coverage, and lock-in future savings.* Room to Grow for the Future of Your Science. Visit www.leica-microsystems.com/growth for package pricing and more information today! *This special offer is valid in the U.S. and Canada only. Living up to Life HIGHLIGHTS from MBoC The Editorial Board of Molecular Biology of the Cell has highlighted the following articles from the July 1 and 15, 2011, issues. From among the many fine articles in the journal, the Board selects for these Highlights articles that are of broad interest and significantly advance knowledge or provide new concepts or approaches that extend our understanding. Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization F.-N. Vögtle, C. Prinz, J. Kellermann, F. Lottspeich, N. Pfanner, and C. Meisinger An increasing number of mitochondrial preproteins are sequentially processed upon import by the presequence mitochondrial processing peptidase (MPP) and the intermediate peptidase octapeptidyl aminopeptidase 1 (Oct1). This study shows that Oct1 removes destabilizing residues from import intermediates generated by MPP. Oct1 therefore acts as a quality control system, preventing premature substrate degradation. Mol. Biol. Cell 22 (13), 2135–2143 The two domains of centrin have distinct basal body functions in Tetrahymena T. Vonderfecht, A. J. Stemm-Wolf, M. Hendershott, T. H. Giddings, Jr., J. B. Meehl, and M. Winey Straight cortical rows of basal bodies in wild-type Tetrahymena (left) contrast with the misoriented cortical row basal bodies in a cell containing a centrin-1 mutant allele with perturbed calcium binding in the two N-terminal EF-hands of the protein (right; green: anti-Sas6a, which labels basal bodies and has a background signal from fibers that run alongside basal bodies; red: centrin). (Image: Tyson Vonderfecht, Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder) The basal body is a microtubule-organizing center responsible for organizing the cilium. A widely conserved basal body component is the Ca2+-binding protein centrin. A mutagenic analysis of the Tetrahymena centrin shows that its two domains have distinct basal body functions and that Ca2+ is necessary for both functions. Mol. Biol. Cell 22 (13), 2221–2234 Vimentin intermediate filaments modulate the motility of mitochondria O. E. Nekrasova, M. G. Mendez, I. S. Chernoivanenko, P. A. Tyurin-Kuzmin, E. R. Kuczmarski, V. I. Gelfand, R. D. Goldman, and A. A. Minin The vimentin N-terminal domain contains the sequence responsible for the interaction with mitochondria. The interaction of vimentin intermediate filaments with mitochondria causes the inhibition of their movements and contributes to their anchoring in cytoplasm. Mol. Biol. Cell 22 (13), 2282–2289 The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella S. Kageyama, H. Omori, T. Saitoh, T. Sone, J.-L. Guan, S. Akira, F. Imamoto, T. Noda, and T. Yoshimori When Salmonella invade mammalian epithelial cells, some populations are surrounded by the autophagy protein LC3. This study shows that LC3 is recruited in proximity to Salmonella independently of both Atg9L1 and FIP200, which are required for formation of autophagosomes. The dynamics of the ULK1 complex and Atg9L1 are dependent on one another. Mol. Biol. Cell 22 (13), 2290–2300 Exposed hydrophobicity is a key determinant of nuclear quality control degradation E. K. Fredrickson, J. C. Rosenbaum, M. N. Locke, T. I. Milac, and R. G. Gardner The yeast nuclear protein quality control ubiquitin ligase San1 recognizes exposed hydrophobicity in its misfolded substrates. San1 recognition is triggered by exposure of as few as five contiguous hydrophobic residues, which defines the minimum window of hydrophobicity required for San1 targeting. Mol. Biol. Cell 22 (13), 2384–2395 16 ASCB NEWSLETTER AUGUST 2011 Bundle-forming pilus retraction enhances enteropathogenic Escherichia coli infectivity E. E. Zahavi, J. A. Lieberman, M. S. Donnenberg, M. Nitzan, K. Baruch, I. Rosenshine, J. R. Turner, N. Melamed-Book, N. Feinstein, E. Zlotkin-Rivkin, and B. Aroeti Enteropathogenic Escherichia coli (EPEC) and other pathogenic bacteria use dynamic type IV pili to adhere to the host. This study shows that the capacity of the EPEC type IV pili to retract is required for the breakdown of the host epithelial tight-junction barrier, efficient actin-pedestal formation, and translocation of effectors via the type III secretion system. Mol. Biol. Cell 22 (14), 2436–2447 A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension J. K. Sawyer, W. Choi, K.-C. Jung, L. He, N. J. Harris, and M. Peifer Coordination of adhesion and the actin cytoskeleton is critical in morphogenesis. Drosophila germband extension is a model for convergent extension. Canoe/afadin is found to have a novel role in this process. It helps to coordinate a contractile apical actomyosin network with cell shape change and regulates apical polarity protein localization. Mol. Biol. Cell 22 (14), 2491–2508 A mechanism of Rap1-induced stabilization of endothelial cell–cell junctions J. J. Liu, R. A. Stockton, A. R. Gingras, A. J. Ablooglu, J. Han, A. A. Bobkov, and M. H. Ginsberg Rap1 stabilizes cell–cell junctions by directly binding to KRIT1, displacing it from microtubules and enabling localization at the junctions. Mol. Biol. Cell 22 (14), 2509–2519 The CSC is required for complete radial spoke assembly and wild-type ciliary motility E. E. Dymek, T. Heuser, D. Nicastro, and E. F. Smith Structural and functional analyses of artificial micro RNA (amiRNA) mutants reveal that the CSC plays a role not only in generating wildtype motility, but also in assembly of at least a subset of radial spokes. This study also produced the unexpected finding that, contrary to current belief, the radial spokes may not be homogeneous. Mol. Biol. Cell 22 (14), 2520–2531 Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells M. Sato, K. Saegusa, K. Sato, T. Hara, A. Harada, and K. Sato Caenorhabditis elegans SNAP-29 is required for the proper morphology and functions of the Golgi and endosomes and general exocytosis. Mol. Biol. Cell 22 (14), 2579–2587 CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast M. Fukuura, K. Nagao, C. Obuse, T. S. Takahashi, T. Nakagawa, and H. Masukata Study of the essential roles of CDK in initiation of DNA replication in fission yeast indicates that CDK phosphorylates Sld3 and Drc1/Sld2 and promotes their interactions with Cut5, which are required for origin loading of Cut5. Thus CDK regulates assembly of replication factors onto origins by promoting ternary Sld3– Cut5–Drc1 complex formation. Mol. Biol. Cell 22 (14), 2620–2633 n AUGUST 2011 ASCB NEWSLETTER The green alga Chlamydomonas has two flagella, as can be seen in the false-colored differential interference contrast microscopy (DIC) image (background). DIC images of single cells with overlaid waveform diagrams show that flagella beat in synchrony in wild type (top left) but out of synchrony in the calmodulin- and spoke-associated complex mutant 6E6 (top right). Cryo-electron tomography of the 6E6 mutant flagella, shown here as graphical 3D model (center) and tomographic slice with overlaid model (bottom), reveals defects in the flagellar structure: Radial spoke 2 (yellow) is frequently missing (red dots), while radial spoke 1 (blue) is unaffected. Occasionally, misplaced spokes are observed (green). (Image: Thomas Heuser and Daniela Nicastro, Department of Biology, Brandeis University, Waltham, MA) 17 PUBLIC POLICY Briefing Congress: They Signed on the Dotted Line—But Will It Matter? One hundred and seventy-one members of the U.S. House of Representatives and U.S. Senate have signed their names to letters supporting the work of the U.S. National Institutes of Health (NIH). The question remains, however, will anyone listen? Members of the House and Senate routinely indicate their support for programs or legislation by signing group letters to congressional leaders and committees. It is a way for individual representatives to show their support, and a way for congressional leaders to gauge support for specific legislative initiatives. Unlike previous years when similar letters included requests for specific budget increases, the letters this year do not make specific requests for funds. Also, in past years, support for the NIH was bipartisan. Unfortunately, unified support for the NIH has fallen victim to the hyper-partisanship that has gripped Congress in recent years. Whether congressional leadership will pay attention to the support of 171 members of Congress won’t be clear until this fall. To read the letters of support for the NIH, go to http://tinyurl.com/FederalSupportofScience. n —Kevin M. Wilson FY12 NSF Budget: A Sign of Things to Come? The U.S. House Appropriations Committee has produced its budget proposal for the National Science Foundation (NSF) and, while the news isn’t good, it could have been much worse. The House Appropriations Subcommittee on Commerce, Justice, Science, and Related Agencies has approved the FY12 Commerce, Justice, Science, and Related Agencies Appropriations (CJS) bill, which includes funding for the NSF and several other federal science agencies. While none of the agencies in the CJS bill received increases in funding, the NSF was the only agency to be funded at the FY11 level. In remarks during the Subcommittee meeting, both the full House Appropriations Committee Chair and the Subcommittee Chair commented on the impact scientific research has on U.S. economic growth. Subcommittee Chair Frank Wolf (R-VA) said, “Despite a 6 18 percent lower allocation in fiscal year 2011, this bill increases funding for research accounts at NIST [National Institute of Standards and Technology] and NSF. Investments in scientific research are critical to long-term economic growth and job creation.” The flat funding for the NSF, and the recognition by U.S. House of Representatives leaders of the economic importance of federally funded scientific research, may be an indication of the U.S. National Institutes of Health (NIH) FY12 budget. A frozen budget is not good for any federal science program. In fact, any increase less than the annual rate of biomedical inflation (BRDPI) is, essentially, a cut. However, with Congress focused on cutting the federal budget’s domestic portion, budget increases of any size are hard to come by. n —Kevin M. Wilson ASCB NEWSLETTER AUGUST 2011 WOMEN in Cell Biology The IRADCA Program Helps Launch Careers in Research and Teaching If you are a recent PhD graduate interested in a career that combines research and teaching, the Institutional Research and Academic Career Development Awards (IRACDA) program may be of value to you. The objective of the program is to build partnerships between researchintensive universities and minority-serving institutions (MSIs) in the U.S. that will simultaneously develop student and faculty talent, promote institutional change, and leverage diversity. National IRACDA Program Network Olivia George The IRACDA program was launched just over 10 years ago through the vision of Clifton Poodry, Director of the Minority Gloriana Trujillo Opportunities in Research programs at the National Institute of General Medical Sciences (NIGMS), with input from institutional training directors across the country. Recently, Shiva Singh assumed responsibility for heading the IRACDA program at NIGMS. There are now 17 programs supporting 192 postdoctoral trainees and 37 MSI partners. Eight IRACDA program directors are women, and two are present or former ASCB Women in Cell Biology (WICB) Committee members. Each IRACDA institution has a unique flavor based on location, number of fellows, whether the research emphasis is interdisciplinary or focused, and the nature of its MSI partner. (MSIs range from community colleges to research universities.) A list of the currently funded IRACDA institutions with website links is available on the NIGMS IRACDA homepage (www.nigms. AUGUST 2011 ASCB NEWSLETTER nih.gov/Training/CareerDev/MOREInstRes. htm). IRACDA programs1 include several that emphasize cell biology: n Academic Science Education and Research Training (ASERT; University of New Mexico) n IRACDA Scholars in Science (University of California, San Francisco) n Training in Education and Critical Research Skills (Tufts University) Triscia Hendrickson Skill Development IRACDA aims to leverage diversity to increase the number of highly qualified science faculty and stimulate undergraduate interest in, and access to, researchAngela Wandinger-Ness oriented science careers through targeted skill development. IRACDA fellows formulate individualized career development plans that include customized research training plus classroom teaching experience at a partner MSI. The program allows fellows to spend about 25% of their time enriching their educational skills, including receiving: n Training in pedagogy n Hands-on experience developing courses and curricula that emphasize student-centered learning n Training in linking learning objectives to assessment n Practical experience in classroom teaching and student mentoring Educational training may occur through local resources/workshops/classes and in partnership with education mentors at the MSIs. Some IRACDA fellows have competed to participate Each IRACDA institution has a unique flavor based on location, number of fellows, whether the research emphasis is interdisciplinary or focused, and the nature of its [minority-serving institution] partner. 19 in the National Science Foundation Faculty face and sharing contact information, IRACDA Institutes for Reforming Science Teaching: fellows make lasting friendships so that exchange Focus on Postdoctoral Scholars program and can continue in spite of distance. in Howard Hughes Medical Institute/National Academy of Sciences faculty development Perspectives of IRACDA programs that emphasize undergraduate biology Participants on Landing a Job and curriculum development. Career Impact Fellows spend the remaining 75% of Several scientists who have participated in their time developing their research skills, IRACDA programs report that the experience through work in cutting-edge has been important for their research areas with programcareers. Nicole Gerardo is affiliated research mentors of currently an assistant professor IRACDA fellows their choosing. Training in in Biology at Emory University. responsible conduct in research, formulate She states that IRACDA communication skills, grant training at the University of individualized writing, scientific writing, and Arizona Postdoctoral Excellence job hunting are among career career development in Research and Teaching development opportunities program helped her while plans that include offered by most programs. interviewing and meeting customized research with prospective colleagues Networking with a with interests in teaching, training plus Community of Peers research, or a combination of classroom teaching the two. Gerardo explains, “My at Local and National experience at a combination of postdoctoral Levels teaching and research IRACDA programs offer the partner [minorityexperience gave me some way opportunity to forge new serving institution]. in which I could relate to partnerships with program everyone that I met with during faculty at the home institution the interview process.” Once and at partnered MSIs through in the new position, Gerardo formal mentor interactions, says she had a lot to learn to get started, but she annual retreats, and career symposia, among felt less nervous about the teaching process than other joint activities. But training is not limited colleagues who did not participate in IRACDA. to local interactions. Networking with faculty Laurie Krug is currently an assistant professor and peers can also extend to other IRACDA at Stony Brook University in the Department programs, conferences, and workshops. For of Molecular Genetics and Microbiology, and example, IRACDA fellows receive funds for travel to research meetings, faculty development Sarah Stabenfeldt is an assistant professor at Arizona State University in the School of workshops, and the annual IRACDA Biological and Health Systems Engineering. conference. Both participated in the FIRST program at The annual IRACDA conference is hosted Emory University, and both had multiple by a different program each year and provides interviews and job offers. They attribute their important opportunities for demonstrating competitive edge to excellent mentoring, likeresearch and education scholarship and for minded peers, a strong teaching portfolio, and learning about job prospects and new research knowledge about new pedagogical techniques and teaching strategies. The poster session is and active learning developed through their a great venue to network among peers and IRACDA training. They will be using these faculty from other institutions; the atmosphere skills in their classrooms. is conducive to exchanging ideas and sharing knowledge. The benefits of networking are How to Apply for IRACDA many, from sharing ideas and knowledge to making important connections that may lead to Postdoctoral Fellowship Positions the next career step. Networking among peers Most IRACDA training programs require can also be a key source of valuable advice and applicants to provide a curriculum vita, support, which can help increase the chances recommendation letters, and a personal of finding funding and job opportunities and statement that details career goals and research building new collaborations. By meeting face-to- and educational experiences. In some cases, 20 ASCB NEWSLETTER AUGUST 2011 the programs encourage prospective fellows to contact potential research mentors before applying to the program, while other programs assist fellows in finding a research lab once they are accepted into the program. Candidates go through a competitive evaluation process, which usually includes interviews with the program director and research and teaching mentors and a seminar presentation. The IRACDA training programs solicit applications annually from recent PhD graduates, usually in the spring with a fall start date. Fellows who are selected for the program receive full stipend support as well as a modest sum for research and/or teaching supplies. Individuals seeking to achieve excellence as both educators and research scientists, women, and those from disadvantaged or underrepresented minority groups are strongly encouraged to apply. n —Olivia George, University of New Mexico; Triscia Hendrickson, Morehouse College; Gloriana Trujillo, University of New Mexico; Angela Wandinger-Ness, University of New Mexico AUGUST 2011 ASCB NEWSLETTER Notes Olivia George and Gloriana Trujillo are ASERT fellows. Triscia Hendrickson participated in the FIRST program at Emory University. Angela Wandinger-Ness is PI of ASERT. The other IRACDA programs are Fellowships in Research and Science Teaching (FIRST; Emory University); Houston Education and Research Training Program (Baylor College of Medicine); IRACDA New Jersey/New York for Science Partnerships in Research & Education (University of Medicine & Dentistry of New Jersey, Robert Wood Johnson Medical School); Medical University of South Carolina IRACDA; Mentored Experiences in Research, Instruction, and Teaching (University of Alabama at Birmingham); Northwestern University Select Teaching and Research Training Program (Northwestern University); PENN–Postdoctoral Opportunities in Research and Teaching (University of Pennsylvania); Postdoctoral Excellence in Research and Teaching (University of Arizona); Professors for the Future (University of California, San Diego); SPIRE (University of North Carolina, Chapel Hill); Stanford University IRACDA; University of Kansas–Haskell Indian Nations University IRACDA; University of Minnesota IRACDA; Virginia Commonwealth University IRACDA. 1 Several scientists who have participated in IRACDA programs report that the experience has been important for their careers. 21 Now Available: Two New iBioSeminars We continue to add to the collection of full-length biology seminars available from iBioSeminars. As always, the seminars are available to all, free of charge. Check out the newest videos at www.ibioseminars.org. Alfred Wittinghofer from the Max Planck Institute for Molecular Physiology, Dortmund, Germany, describes the 3D structure of G-proteins, what the structure tells us about G-protein function, and about the link between G-proteins and disease. Kai Simons of the Max Planck Institute of Cell Biology and Genetics, Dresden, Germany, explains how lipids act as key organizers in cell membranes, from lipid rafts to glycolipid-rich apical membranes in epithelial cells. In addition, iBioMagazine Issue 4 is now live at www.ibiomagazine.org. n Did You Know...? September 1 is the regular abstract submission deadline (for poster consideration only) for this year’s ASCB Annual Meeting; the meeting will be held December 3–7 in Denver, CO, USA. The meeting is the place to get expert feedback, meet collaborators, and discuss your research. There’s also no better place for postdoc and other interviews—and career development guidance. n Sponsorship of abstracts is required. n All current members and member applicants may sponsor their own abstract. n All regular, postdoctoral, and emeritus members may sponsor another person’s abstract if they are not submitting one themselves. Are There Nonmembers in Your Lab Who Want to Submit Abstracts? Now is the time to encourage them to join ASCB. Not only will they be able to sponsor their own abstract, they will be eligible for the discounted member-only registration rate too. For more information, go to www.ascb.org and click on “Membership.” n CLS Congressional Biomedical Research Caucuses Illuminate Science, Showcase Need for Federal Funding The Coalition for the Life Sciences (CLS), co-founded by the ASCB, sponsors timely and thought-provoking briefings for the Congressional Biomedical Research Caucus (CBRC). Left: In June Keith Flaherty from the Massachusetts General Hospital Cancer Center briefed the CBRC on the latest breakthroughs in melanoma therapies. Flaherty (left) is shown with Congressman Rush Holt (right, D-NJ), a co-chair of the CBRC. Far right: Joanna Wysocka of Stanford University School of Medicine spoke on ”Making a Face: What Epigenomics Can Teach Us about Human Development.” The CLS videotapes the briefings, which are available at www.coalitionforlifesciences.org. 22 ASCB NEWSLETTER AUGUST 2011 Canadian research has made numerous important contributions to cell biology. James Till and Ernest McCulloch at the University of Toronto helped identify stem cells. Yoshio Masui, also at the University of Toronto, contributed to the discovery of cell cycle regulators. Nahum Sonenberg at McGill University revealed how the cell controls translation initiation. The invention of sitedirected mutagenesis by Michael Smith at the University of British Columbia revolutionized how we use molecular biology Amy Shaub Maddox to study cells. Many others have made groundbreaking discoveries in cell biology and its interface with developmental biology, cellular signaling, cancer, immunology, neurobiology, and systems biology. Research in Canada Canada’s largest research communities are in its major cities: Toronto, Montreal, Vancouver, Calgary, and Edmonton. These communities are centered around public universities with associated research institutes and hospitals, and are as large as any in the U.S. Smaller universities also make important contributions to research and training, and are located across the country. As in other countries, the major centers are more research-intensive, and teaching contributions are considerably greater at the smaller universities. Canadian biomedical research makes a broad range of fundamental and clinical contributions, and government programs are promoting increased translational research. Funding in Canada Recently, there has been major growth in the biomedical research community in Canada. AUGUST 2011 ASCB NEWSLETTER This expansion was spurred by the Canada Research Chairs program, which was initiated by the Canadian government in 2000. These and other salary grants from federal and provincial sources have recruited many young cell biologists to Canada as PIs. Alongside this salary support, the Canada Foundation for Innovation (CFI; another federal government agency) has equipped the new labs and provided funds for state-ofthe-art microscopes and other “big” equipment items. Operating Tony J.C. Harris funds are available from two major federal sources and other more specialized granting organizations. The Canadian Institutes of Health Research (CIHR) has a mandate comparable to that of the U.S. National Institutes of Health and provides operating grants for three to four lab personnel, with a success rate of approximately 17% in the last competition. The Natural Sciences and Engineering Research Council of Canada (NSERC) is the counterpart of the U.S. National Science Foundation and provides smaller operating grants for one to three lab personnel, with a success rate of approximately 57% in the last competition. Both of these agencies also offer special funding opportunities, as does Genome Canada, which mostly funds large projects in high-throughput genomics. Grants are also available from specialized foundations such as the Cancer Research Society, Heart and Stroke Foundation, The Foundation Fighting Blindness, Canadian Diabetes Association, The Terry Fox Foundation, and others, including provincial government agencies like les Fonds de la recherche en santé du Québec (FRSQ). nationa r e t fai l Af rs Cell Biology, Eh! Yes, It’s Great in Canada. La Biologie Cellulaire au Canada— Oui, Ça Marche! In INTERNATIONAL Affairs Prestigious fellowships, including the Banting, awarded by the CIHR, have been initiated to attract the best scientists from all over the world. 23 multicultural, safe, fun, and livable. This allows researchers to live relatively close to work, in a neighborhood with convenient shopping, parks, and good public schools. We also enjoy universal healthcare and community services (including affordable daycare in Québec). Although our winters are colder and longer than in most of the U.S., we are well equipped to weather them and Training in Canada Graduate training in Canada is distinct from that embrace the chance to practice winter sports. Because Canadian domestic and international in the U.S. and Europe in that most students policy tends to be financially conservative, initially pursue a Master’s of Science (MSc) we fared relatively well in the degree. All major universities recent financial crisis. In some have MSc and PhD programs. ways Canada is quite distinct Students who decide to pursue from the U.S., but we are research typically transfer into The main challenge close enough for convenient the PhD program after one to facing Canadian travel to our neighbor to the two years, and complete their south. PhD in five to six years of total scientists is the graduate training. Students who same facing decide to pursue nonacademic Challenges our colleagues biomedical positions, The main challenge facing professional schools, or related Canadian scientists is the all around the work can finish their MSc degree same facing our colleagues all world: securing in two to three years. around the world: securing Graduate students and operating funds. Two factors operating funds. postdoctoral fellows are eligible specifically impact our for trainee fellowships from all struggle. First, the recent burst the major federal and provincial of new hires stimulated by funding agencies (CIHR, NSERC, etc.), as well the creation of the Canada Research Chair as from some foundations. Similar to eligibility salary awards added many new investigators in other systems, eligibility for postdoc to the pool competing for operating grants. fellowships is limited to a set amount of time Also, a rearrangement within the major after receipt of the PhD. A typical proportion of cancer agency (the Canadian Cancer Society trainees holding independent funding at major Research Institute) recently eliminated its research centers is 30%. basic science operating grant program. This Canadian departments tend to have a smaller has forced many researchers to find alternate cadre of postdocs versus those in the U.S. funding sources. To help address funding Prestigious fellowships, including the Banting, challenges, the Canadian equivalent of the awarded by the CIHR, have been initiated ASCB, the Canadian Society for Biochemistry to attract the best scientists from all over the and Molecular and Cellular Biology, promotes research advocacy and encourages members to world. The small postdoc population is in part lobby government officials for investment in due to the fact that many Canadians go to the basic research. U.S. (and elsewhere) for postdoctoral training Another challenge to Canadian research is (they can be identified by their classic “out” and the geographic separation of the major centers “about” pronunciation, or when asking for a of our large country. Nonetheless, the Canadian “serviette” instead of a napkin). Many return to cell biology community is vibrant, strong, and Canada to start their independent career, but as tight-knit as our tuques. n many new PIs in Canada are Americans and Amy Shaub Maddox, Institute for Research other nationalities. in Immunology and Cancer and Department Life in Canada of Pathology and Cell Biology, University of Life in Canada is great. In the cities of major Montreal; and Tony J.C. Harris, Department of research centers, the downtown areas are Cell and Systems Biology, University of Toronto Interestingly, in Canada, faculty salaries can never be taken from operating funds. Instead, they can be garnered independently in the form of salary awards and/or are provided by the professor’s university department. After tenure, this salary is typically guaranteed by the university. 24 ASCB NEWSLETTER AUGUST 2011 MEMBERS in the News Four ASCB members were among the 15 scientists from across the U.S. selected by Howard Hughes Medical Institute (HHMI) and the Gordon and Betty Moore Foundation (GBMF) as HHMI-GBMF investigators: Simon Chan Joseph R. Ecker University of California, Davis First became a member in 1997 The Salk Institute Member since 2001 MEETINGS Calendar A complete list of upcoming meetings can be found at http://ascb.org/ othermeetings.php. The following meetings were added since the last issue of the Newsletter: September 17–20, 2011. Chicago, IL 51st Interscience Conference on Antimicrobial Agents and Chemotherapy. www.icaac.org. October 24–26, 2011. Knoxville, TN National Institute for Mathematical and Biological Synthesis Workshop on Mathematical Modeling of Intracellular Movements. www.nimbios.org/workshops/WS_intracellular_mv. February 2–5, 2012. Florence, Italy International Congress on Personalized Medicine: Up Close and Personalized. www.upcp.org. March 21–24, 2012. Dresden, Germany 35th Annual Meeting of the German Society for Cell Biology. www.zellbiologie2012.de. May 18–23, 2012. San Francisco, CA 2012 American Thoracic Society International Conference. www.thoracic.org/go/international-conference. Elliot Meyerowitz Keiko Torri California Institute of Technology First became a member in 1993 University of Washington Member since 2010 ASCB Annual Meetings Correction December 3–7, 2011. Denver Newly elected 2012 Council member Sue Biggins’s correct affiliation is: Full Member, Division of Basic Sciences, Fred Hutchinson Cancer Research Center. n December 14–18, 2013. New Orleans December 15–19, 2012. San Francisco 2011 Half-Century Fund Donors The ASCB is grateful to the following donors* whose contributions support Society activities: Gold Kenneth Yamada Sandra L. Schmid December 6–10, 2014. Philadelphia December 12–16, 2015. San Diego In Memoriam We note the recent passing of ASCB emeritus member Betty Clark Moore, and express our condolences to her family, friends, and colleagues. n MEMBER Gifts Sustainer Jim Clegg Paul Forscher Jani Lewis Maryanne McClellan Rita Miller The ASCB is grateful to the following members who have recently given a gift to support Society activities: Dorothy E. Croall Marvin J. Fritzler *As of July 19, 2011 Maryanne C. Herzig Peter Hornbeck Elizabeth C. Raff AUGUST 2011 ASCB NEWSLETTER 25 GRANTS & OPPORTUNITIES Enhancing Zebrafish Research with Research Tools and Techniques (R01). The National Institute of General Medical Sciences encourages applications designed to exploit the power of the zebrafish as a vertebrate model for biomedical and behavioral research. Applications due: September 19, 2011, 2012, and 2013. http://grants.nih.gov/grants/guide/pa-files/PAR-11-131.html. High-Throughput-Enabled Structural Biology Research (U01). The National Institute of General Medical Sciences (NIGMS) encourages applications to establish partnerships between researchers interested in a biological problem of significant scope and researchers providing high-throughput structure determination capabilities through the NIGMS PSI:Biology network. Applicants should propose work to solve a substantial biological problem for which the determination of many protein structures is necessary. Expiration: September 8, 2014. http://grants.nih.gov/grants/guide/pa-files/PAR-11-176.html. Mentored Quantitative Research Development Award (K25). The purpose of these National Institutes of Health (NIH) awards is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. Expiration: January 8, 2012. http://grants.nih.gov/grants/guide/pa-files/PA-09-039.html. Minority Access to Research Careers Undergraduate Student Training in Academic Research National Research Service Award Institutional Research Training Grant (T34). The National Institute of General Medical Sciences will award these grants to eligible institutions as a means of supporting undergraduate academic and research training for students underrepresented in the biomedical and behavioral sciences. Applications due: May 25, 2012. http://grants.nih.gov/grants/guide/pa-files/PAR-10-119.html. Nanoscience and Nanotechnology in Biology and Medicine (R01). The National Institutes of Health encourages applications from institutions/organizations that apply nanoscience and nanotechnology approaches to address problems in biology and medicine. Expiration date: May 8, 2014. http://grants.nih.gov/grants/guide/pa-files/PA-11-148.html. The National Academies’ Research Associateship Programs administer postdoctoral (within five years of the doctorate) and senior (normally five years or more beyond the doctorate) research awards sponsored by federal laboratories at over 100 locations in the U.S. and overseas. Quarterly application deadlines. www7.nationalacademies.org/rap. National Centers for Biomedical Computing (R01). This funding opportunity is for projects from individual investigators or small groups to collaborate with the National Institutes of Health Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs). Collaborating projects are intended to engage researchers in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. Expiration: September 8, 2011. http://grants.nih.gov/grants/guide/pa-files/PAR-08-184.html. National Centers for Systems Biology (P50). The National Institute of General Medical Sciences invites grant applications from institutions/organizations proposing to establish Centers of Excellence in Systems Biology. Letters of intent due: September 28, 2011. Applications due: October 27, 2011. http://grants.nih.gov/grants/guide/pa-files/PAR-10-200.html. The National Science Foundation Division of Molecular and Cellular Biosciences Investigator-initiated Grants. The National Science Foundation has implemented a new eight-month cycle for proposal submission and review in response to its solicitation 11-545. Deadline: September 6, 2011. www.nsf.gov/div/index.jsp?div=MCB. Pathway to Independence Award. The primary purpose of the National Institutes of Health (NIH) Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented NIHsupported independent investigators. The program is designed to facilitate a timely transition from a mentored postdoctoral research position to a stable independent research position with independent NIH or other independent research support at an earlier stage than is currently the norm. Expiration: January 8, 2012. http://grants.nih.gov/grants/guide/pa-files/PA-09-036.html. Research Supplements to Promote Diversity in Health-related Research. The National Institutes of Health (NIH) and the Centers for Disease Control and Prevention have announced to PIs holding specific types of NIH research grants that funds are available for administrative supplements to improve the diversity of the research workforce by supporting and recruiting students, postdoctoral researchers, and eligible investigators from groups that have been shown to be underrepresented. Expiration: September 30, 2011. http://grants.nih.gov/grants/guide/pa-files/PA-08-190.html. 26 ASCB NEWSLETTER AUGUST 2011 GRANTS & OPPORTUNITIES Research Supplements to Promote Re-entry into Biomedical and Behavioral Research Careers. These supplements are intended to encourage individuals to re-enter research careers within the missions of all National Institutes of Health (NIH) program areas. This program will provide administrative supplements to existing NIH research grants to support full-time or part-time research by individuals in a program geared to bring their existing research skills and knowledge up-to-date. Expiration: September 30, 2011. http://grants.nih.gov/grants/guide/pa-files/PA-08-191.html. SHIFT Awards: Small Businesses Helping Investigators to Fuel the Translation of Scientific Discoveries (SBIR: R43/R44). These National Institutes of Health awards are intended to foster research that is translational in nature and to transform academic scientific discoveries into commercial products and services. They require that an investigator who is primarily employed by a U.S. research institution at the time of application transition to a small business concern (SBC) and be primarily employed (more than 50% time) by the SBC by or at the time of the award. Expiration: January 8, 2013. http://grants.nih.gov/grants/guide/pa-files/PA-10-122.html#SectionIV3A. Structural Biology of Membrane Proteins (R01). This National Institutes of Health funding opportunity is for research that will lead to the determination of membrane protein structures at high resolution. In addition to the structures of integral membrane proteins, the structures of the complexes formed between these proteins and their biological partners are of interest. Expiration: September 8, 2013. http://grants.nih.gov/grants/guide/pa-files/PA-10228.html. Supplements for Functional Studies Based on High-resolution Structures Obtained in the Protein Structure Initiative. The National Institute of General Medical Sciences (NIGMS) announces the availability of administrative supplements to provide funds to enable investigators interested in protein function to capitalize on the information and material products of the Protein Structure Initiative (PSI). These supplements are available for 1) NIGMS-funded research grants (R01, R37, and P01) as well as 2) investigators with peer-reviewed research grants not funded by NIGMS, through the PSI research centers. www.nigms.nih.gov/initiatives/PSI/supplements. Support of NIGMS Program Project Grants (P01). The National Institute of General Medical Sciences encourages innovative, interactive program project grant applications from institutions/organizations that propose to conduct research that aims to solve a significant biological problem through a collaborative approach involving outstanding scientists who might not otherwise collaborate. Expiration: September 8, 2014. http://grants.nih.gov/grants/guide/pa-files/PAR-10-266.html. n Make Science News—Help the ASCB Public Information Committee! If you think top research in cell biology deserves more positive attention by the public, here’s your chance to contribute. The Public Information Committee (PIC) needs some sharp minds and tireless eyeballs to screen abstracts submitted for the ASCB Annual Meeting. The Committee’s mission is to select top-breaking science in cell biology for inclusion in “Cell Biology 2011,” the ASCB’s press book for journalists covering the meeting in Denver. Here’s how you can help… Starting August 11, PIC members and PIC Associates will quickly winnow the roughly 1,200 abstracts submitted for panel presentation at the 2011 Annual Meeting down to a dozen. The top abstracts will be highlighted in the press book and promoted to press outlets worldwide. There are lots of ways to promote the importance of cell biology, but we can’t do it without you! Contact PIC Chair Simon Atkinson (satkinso@iupui.edu) or ASCB Science Writer John Fleischman (jfleischman@ascb.org) for details. n “ASCB,” “The American Society for Cell Biology,” “iBioSeminars,” and “Molecular Biology of the Cell” are registered trademarks of The American Society for Cell Biology. “The Cell: An Image Library” is a common law trademark of The American Society for Cell Biology. AUGUST 2011 ASCB NEWSLETTER 27 8120 Woodmont Avenue Suite 750 Bethesda, MD 20814-2762 USA Non-profit Organization US Postage PAID York, PA Permit No. 356 Wanted: Teachers, Scientists, Students, Parents, and Science Enthusiasts Help contribute to a collection of engaging, inexpensive experiments for students from kindergarten through high school. The U.S. National Institutes of Health (NIH) Lab Challenge is looking for experiments that: n Are geared toward grades K to 12 n Use safe, easily available, inexpensive materials n Take 90 minutes (or less) of class time n Have at least one clear learning objective n Are related to health and life science The submission deadline is December 1, 2011. For more details (and to find out what you can win!) visit http://LAB. challenge.gov. n Annual Meeting Hotel Savings and Perks, Just for You Through our official housing partner, onPeak, we have secured the lowest rates, most amenities, and best hotels for your stay in Denver for the ASCB 2011 Annual Meeting. Book now for the best selection and lowest rates available. When you are ready to make a reservation, we offer multiple ways to book: n Online: www.ascb.org/meetings n By phone: 800-220-9540 U.S. toll-free / 312-527-7300 international n By email: ascb@onpeakevents.com n A Note to Our International Annual Meeting Attendees Have you applied for your visa? Because the application process may take three or more months, please register immediately for the 2011 ASCB Annual Meeting at www.ascb.org/meetings. On the registration form, please request a letter of invitation for use in your visa application. Visit www.ascb.org/meetings/visa_passport.cfm for more visa and passport information. See you in Denver! n