June 2012
Sidney Siu Bun Yu
School of Biomedical Sciences, The Chinese University of Hong Kong
Room 606A, Lo Kwee-Seong Integrated Biomedical Sciences Building
Shatin, New Territories, Hong Kong
Tel: 852-3943-6796 ; 852-6841-0635
sidney.yu@cuhk.edu.hk ; smdyu1@yahoo.com
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Education
Bachelor of Arts (1994)
Majoring in Molecular and Cell Biology
University of California, Berkeley
Doctor of Philosophy (2002)
University of Texas, Southwestern Medical Center
Graduate Program of Cell Regulations
Appointment
Postdoctoral associate (2002-2003)
Department of Pathology
Yale University, School of Medicine
Postdoctoral associate (2003-2007)
HHMI, Department of Cell Biology
Yale University, School of Medicine
Research Associate, HHMI (2007- 2008)
Associate Research Scientist, Department of Cell Biology
Yale University, School of Medicine
Research Assistant professor (independent position and lab head) (2008- )
School of Biomedical Sciences
The Chinese University of Hong Kong
Professional experiences
Visiting professor, Key Lab of Visual Science, Wenzhou Medical College (2010- )
Co-editor, Cell Biology International (2010- )
Funding awarded
University Direct Grant 2009 (P.I.)
Project title: Cell biology studies of pre-chylomicron transport vesicles in Caco-2 cells
Hong Kong RGC General Research Fund 2011.1.1---2012.12.31(P.I.)
Project title: Mechanism of vesicle tethering in mammalian cells
Focused Investments Scheme - Scheme D (MD08384) 2009.1.1 to 2014.9.30 (Co-I.)
Project title: Investigation of Molecular Mechanisms Underlying the Pathogenesis of
Respiratory Diseases and Injuries
Representative Publications
Zong M, Satoh A, Yu MK, Siu KY, Ng WY, Chan HC, Tanner TA, and Yu S. (2012)
TRAPPC9 mediates the interaction between p150Glued and COPII vesicles at the target membrane
PLoS ONE 7(1): e29995
Zong M, Wu XG, Chan CWL, Choi MY, Chan HC, Tanner JA, and Yu S. (2011)
The Adaptor Function of TRAPPC2 in Mammalian TRAPPs Explains TRAPPC2-Associated SEDT
and TRAPPC9-Associated Congenital Intellectual Disability
PLoS ONE 6(8): e23350.
Siu KY, Yu MK, Roth MG, Chan HC, and Yu S. (2011)
The non-catalytic carboxyl-terminus of ARFGAP1 inhibits cell spreading and antagonizes activation of
Rac1
PLoS ONE 6(4): e18458
Cai H, Yu S, Menon S, Cai Y, Lazarova D, Fu C, Reinisch K, Hay JC, Ferro-Novick S. (2007)
TRAPP I tethers COP II vesicles by binding the coat subunit Sec23p
Nature 445, 941-944
Yu S, Satoh A, Pypaert M, Mullen K, Hay JC, Ferro-Novick S. (2006).
mBet3p is required for homotypic COPII vesicle tethering in mammalian cells
Journal of Cell Biology 174, 359-368
Feng Y, Yu S, Lasell TKR, Jadhav AP, Macia E, Chardin P, Melancon P, Roth MG, Mitchitson T,
Kirchausen T. (2003).
Exo1, a new chemical inhibitor of the secretory pathway.
Proceedings of the National Academy of Sciences of USA 100, 6469-6474
Yu S, and Roth MG. (2002).
Casein kinase I regulates membrane-binding by ARF GAP1.
Molecular Biology of the Cell 13, 2559-2570.
Yu S, Avery L, Baude E, and Garbers D. (1997).
Guanylyl cyclase expression in specific sensory neurons: A new family of chemsensory receptors.
Proceedings of the National Academy of Sciences of USA 94, 3384-3387.