CURRICULUM VITAE
Name : Hsiang-fu Kung, Ph.D.
Education:
1963 B.S. 1969 Ph.D1969-1971-
National Chung Hsiang University, Department of Agricultural Chemistry, Taichung,
Taiwan
Vanderbilt University, Department of Biochemistry, School of Medicine, Nashville,
Tennessee, USA
NIH, Postdoctoral Fellow, Bethesda, Maryland, USA
Previous Related Experience :
1982-1986 -
Research Leader, Department of Molecular Genetics & Molecular Oncology Research
Division, Hoffmann-La Roche Inc., Nutley, NJ
1986-Date - Adjunct Professor Department of Chemical Biology & Pharmacognosy, College of
Pharmacy, Rutgers University, Piscataway, NJ 08854
1986-1999 - Chief, Laboratory of Biochemical Physiology, NIH, NCI, Frederick, MD
1999-2004 - Director, Chair Professor, Institute of Molecular Biology, HKU
Membership : Chinese Academy of Sciences
Federation of American Societies for Experimental Biology
American Association for the Advancement of Science
Other Academic Activities :
1986-Date - Editorial Board, BioFactors
1991-1996 - Editorial Board, Cellular and Molecular Biology Research
Visiting Professorship & Lectures – Kyutsu University (Japan), Ben Gurion University (Israel),
Academia Scinica (Taiwan), National Health Research Institute (Taiwan), National
Taiwan University, Academy of Military Medical Sciences (Beijing), Hunan Medical
University (Changsha), China Medical University (Shengyang), Fu-Dan University
(Shanghai), Jiao-fung University (Shanghai), Tong-ji Medical University (Wuhan),
Zhong Shan University Medical School (Guangzhou), Development Center of
Biotechnology (Taiwan).
Adjunct Professorship: Rutgers University, New Jersey, USA
Current Positions :
Chair Professor of Virology
Centre for Emerging Infectious Diseases
The Chinese University of Hong Kong
Honorary Professor
Peking Union Medical College
Beijing, China
Adjunct Professor
Dept of Chemical Biology
College of Pharmacy
Rutgers University
Hsiang-fu Kung, Ph.D.
New Jersey, USA
Publications :
420 Peer-reviewed papers
15 Book Chapters
14 Patents
Awards : 1998 NIH Merit Award
2000 HKU Outstanding Research Award
Peer-Reviewed Publications (Books/Book Chapters and Abstracts are not included) :
1.
Wagner, C., Lusty S.M., Kung, H.F., and Rogers, N.L.: Trimethyl-sulfonium-tetrahydrofolate
methyltransferase: A novel enzyme in the utilization of one- carbon units. J. Biol. Chem.
241:1923-1925, 1966
2.
Wagner, C., Lusty, S.M., Kung, H.F., and Rogers, N.L.: Preparation and properties of
trimethylsulfonium tetrahydrofolate methyltransferase. J. Biol. Chem. 242:1287-1293, 1967
3.
Kung, H.F. and Wagner, C.: -glutamylmethylamine: A new intermediate in the metabolism of
methylamine. J. Biol. Chem. 244:4136-4140, 1969
4.
Kung, H.F. and Wagner, C.: Oxidation of one-carbon units by Pseudomonas MS. Biochem. J.
116:357-365, 1970
5.
Kung, H.F. and Wagner C.: The enzymatic synthesis of N-methylalanine by Pseudomonas MS.
Biochim. Biophys. Acta. 201:513-516, 1970.
6.
Kung, H.F., Cederbaum, S., Tsai, L., and Stadtman, T.C.: V. nicotinic acid metabolism: A
conbamide coenzyme dependent conversion of -methyl-eneglutaric acid to dimethylmaleic acid.
Proc. Natl. Acad. Sci. USA 65:978-984, 1970.
7.
Kung, H.F. and Stadtman, T.C.: VI. Nicotinic acid metabolism: Purification and properties of methyleneglutarate mutase (B12-dependent) and methylitaconate isomerate. J. Biol. Chem.
246:3378-3388, 1971.
8.
Kung, H.F. and Tsai, L.: VII. Nicotinic acid metabolism: Mechanism of action of clostridial methyleneglutarate mutase (B12-dependent) and methylaitaconate isomerase. J. Biol. Chem.
246:6436-6443, 1971.
9.
Kung, H.F., Tsai, L., and Stadtman, T.C.: VIII. Nicotinic acid metabolism: Tracer studies on the
intermediary roles of a-methyleneglutarate, methylitaconate, dimethylmatlate, and pyruvate. J.
Biol. Chem. 246:6444-6451, 1971.
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Hsiang-fu Kung, Ph.D.
10.
Kung, H.F. and Henning, U.: Limiting availability of binding sites for dehydrogenases on the
cell membrane of E. coli. Proc. Natl. Acad. Sci. USA 69:925-929, 1972.
11.
Kung, H.F., Spears, C., Greene, R.C., and Weissbach, H.: Regulation of the terminal reactions in
methionine biosynthesis by vitamin B12 and methionine. Arch. Biochem. Biophys. 150:23-31,
1972.
12.
Greene, R.C., Williams, R., Kung, H.F., Spears, C., and Weissbach, H.: Effects of methionine
and vitamin B12 on the activities of methionine biosynthesis enzymes in Met J Mutants of E. coli
K-12. Arch. Biochem. Biophys. 158:249-256, 1973.
13.
Kung, H.F., Fox, J.E., Spears, C., Brot, N., and Weissbach, H.: Studies on the role of ribosomal
proteins L7 and L12 in the in vitro synthesis of -galactosidase. J. Biol. Chem. 248:5012-5015,
1973.
14.
Kung, H.F., Brot, N., Spears, C., Chen, B., and Weissbach, H.: Studies on the in vitro
transcription and translation of lac operon. Arch. Biochem. Biophys. 160:168-174, 1974.
15.
Kung, H.F., Spears, C., Schulz, T., and Weissbach, H.: Studies on the in vitro synthesis of galactosidase: Necessary components in the ribosomal wash. Arch. Biochem. Biophys. 162:578584, 1974.
16.
Kung, H.F., Spears, C., and Weissbach, H.: Purification and properties of a soluble factor
required for the in vitro synthesis of -galactosidase. J. Biol. Chem. 250:1556-1562, 1975.
17.
Schuldiner, S., Kung, H.F., Kaback, H.R., and Weil, R.: Differentiation between binding and
transport of dansylga-lactosides in E. coli. J. Biol. Chem. 250:3679-3682, 1975.
18.
Kung, H.F., Morrissey, J., Revel, M., Spears, C., and Weissbach, H.: Studies of the lactose
operon: The control of DNA-directed in vitro protein synthesis by interference factor i-. J. Biol.
Chem. 250:8780-8784, 1975.
19.
Kung, H.F., Spears, C., and Weisshach, H.: DNA-directed in vitro synthesis of -galactosidase:
Dependencies on elonga-tion factor Tu and tRNA. Arch. Biochem. Biophys. 174:100-104, 1976.
20.
Chen, B., Kung, H.F., and Bates, R.R.: Significance of methylation of template DNA on its
coded enzyme -galactosidase synthesis in vitro. Chem. Biol. Interact. 14:101-111, 1976.
21.
Treadwell, B.V., Kung, H.F., and Weissbach, H.: Stimulation by spermidine on the DNAdirected in vitro synthesis of -galactosidase. Arch. Biochem. Biophys. 176:799-800, 1976.
22.
Chu, F., Kung, H.F., Caldwell, P., Weissbach, H., and Brot, N.: DNA-directed in vitro synthesis
of protein L7 L12 from E. coli ribosomes in vitro. Proc. Natl. Acad. Sci. USA 73:3156-3159,
1976.
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Hsiang-fu Kung, Ph.D.
23.
Kung, H.F., Treadwell, B., Spears, C., Tai, P.C., and Weissbach, H.: DNA-directed in vitro
synthesis of -galactosidase: Requirement for a ribosome release factor. Proc. Natl. Acad. Sci.
USA 74:3217-3221, 1977.
24.
Kung, H.F., Redfield, B., Treadwell, B., Spears, C., and Weissbach, H.: DNA-directed in vitro
synthesis of -galactosidase: Studies with purified factors. J. Biol. Chem. 252:6889-6894, 1977.
25.
Kung, H.F., Chu, F., Caldwell, P., Spears, C., Treadwell, B., Eskin, B., Brot, N., and Weissbach,
H.: The mRNA-directed synthesis of the -peptide of -galactosidase, ribosomal proteins, L12
and L10, and EF-Tu using purified translational factors. Arch. Biochem. Biophys. 187:457-463,
1978.
26.
Kung, H.F., and Weissbach, H.: DNA-directed synthesis of E. coli -isopropylmalate
dehydrogenase in vitro. J. Biol. Chem. 253:2078-2080, 1978.
27.
Kung, H.F., Tainsky, M., and Weissbach, H.: Regulation of the in vitro synthesis of the peptide of -galactosidase by a restriction fragment of the lactose operon. Biochem. Biophys.
Res. Commun. 81:1000-1010, 1978.
28.
Eskin, B., Treadwell, B., Redfield, B., Spears, C., Kung, H.F., and Weissbach, H.: Activity of
different forms of initiation factor 2 in the in vitro synthesis of -galactosidase. Arch. Biochem.
Biophys. 195:396-400, 1979.
29.
Kung, H.F., Eskin, B., Redfield, B., and Weissbach, H.: DNA-directed in vitro synthesis of galactosidase: Requirement for formylation of methionyl-tRNA. Arch. Biochem. Biophys.
195:396-400, 1979.
30.
Kung, H.F., Redfield, B., and Weissbach, H.: DNA-directed in vitro synthesis of -galactosidase:
Purification and characterization of stimulatory factors in an asites extract. J. Biol. Chem.
254:8404-8408, 1979.
31.
Schulz, T., Jerez, C., Goldberg, G., Kung, H.F., Huang, K.H., Brot, N., and Weissbach, H.:
DNA-directed in vitro synthesis of protein involved in bacterial transcription and translation.
Proc. Natl. Acad. Sci. USA 76:6115-6119, 1979.
32.
Kung, H.F., and Weissbach, H.: Further characterization of L-factor, a protein required for galactosidase synthesis. Arch. Biochem. Biophys. 201:544-550, 1980.
33.
Greenblatt, J., Li, J., Adhya, S., Friedmaan, D.I., Baron, L.S., Redfield, B., Kung, H.F., and
Weissbach, H.: L factor required for -galactosidase synthesis is the nus A gene product that is
involved in transcription termination. Proc. Natl. Acad. Sci. USA 77:1991-1994, 1980.
34.
Shen, V., Cynamon, M., Daugherty, B., Kung, H.F., and Schlessinger, D.: Functional
inactivation of lac -peptide mRNA by a factor that purifies with E. coli RNase III. J. Biol.
Chem. 256:1896-1902, 1981.
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Hsiang-fu Kung, Ph.D.
35.
Staehelin, T., Hobbs, D., Kung, H.F., Lai, C.Y., and Pestka, S.: Purification and characterization
of recombinant human leukocyte interferon (IFL-r) with monoclonal antibodies. J. Biol. Chem.
256:9750-9754, 1981.
36.
Miller, D., Kung, H.F., and Pestka, S.: Crystallization of recombinant human leukocyte
interferon A. Science 215:689-690, 1982.
37.
Staehelin, T., Durrer, B., Schmidt, J., Takacs, B., Stocker, J., Miggiano, V., Stahli, C., Kung,
H.F., Hobbs, D.S., Levy, W.P., Moschera, J.A., and Pestka, S.: Monoclonal antibodies to human
leukocyte interferon: Their use in assay and purification. Tex. Rep. Biol. Med. 41:43-58, 1982.
38.
Herberman, R.B., Ortaldo, J.R., Mantovani, A., Hobbs, D.S., Kung, H.F., and Pestka, S.: Effect
of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes.
Cell Immunol. 67:160-167, 1982.
39.
Chanda, P.K. and Kung, H.F.: In vitro synthesis of biologically active human leukocyte
interferon in a RNA-dependent system from Saccharomyces cerevisiae. Proc. Natl. Acad. Sci.
USA 80:2569-2573, 1983.
40.
Chang, N.T., Kung, H.F., and Pestka, S.: Synthesis of a human leukocyte interferon with a
modified carboxy terminus in E. coli. Arch. Biochem. Biophys. 221:585-589, 1983.
41.
Kung, H.F., Bekesi, E., Guterman, S.K., Gray, J.E., Traub, L., and Calhoun, D.H.:
Autoregulation of the rho gene E. coli K-12. Mol. Gen. Genet. 193:210-213, 1984.
42.
Stacey, D.W. and Kung, H.F.: Transformation of NIH 3T3 cells by microinjection of H-ras p21
protein. Nature 310:508-511, 1984.
43.
Lacal, J.C., Santos, E., Notario, V., Barbacid, M., Yamazaki, S., Kung, H.F., Seamans, C.,
McAndrew, S., and Crowl, R.: Expression of normal and transforming ras genes in E. coli and
purification of their encoded p21 proteins. Proc. Natl. Acad. Sci. USA 81:5305-5309, 1984.
44.
Manne, V., Yamazaki, S., and Kung, H.F.: Guanosine nucleotide binding by highly purified Hras p21 protein produced in E. coli. Proc. Natl. Acad. Sci. USA 81:6953-6957, 1984.
45.
Chanda, P., Ono, M., Kuwano, M., and Kung, H.F.: Cloning sequence analysis and expression of
alteration of mRNA stability gene (Ams) of E. coli. J. Bacteriol. 161:446-449, 1985.
46.
Calhoun, D.H., Wallen, J.W., Traub, L., Gray, J.E., Ast, M., and Kung, H.F.: Internal promoter
in the ilvGEDA transcription unit of E. coli K-12. J. Bacteriol. 161-128-132, 1985.
47.
Manne, V., Bekesi, E., and Kung, H.F.: H-ras proteins exhibit GTPase activity – point mutation
that activate H-ras gene products result in decreased GTPase activity. Proc. Natl. Acad. Sci.
USA 82:376-380, 1985.
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Hsiang-fu Kung, Ph.D.
48.
Rashidbaigi, A., Kung, H.F., and Pestka, S.: Characterization of receptors for immune interferon
in U937 cell line with (32P)-labelled human recombinant immune interferon. J. Biol. Chem.
260:8514-8519, 1985.
49.
Manne, V. and Kung, H.F.: Effect of divalent metal ions and glycerol on the GTPase activity of
H-ras proteins. Biochem. Biophys. Res. Commun. 128:1440-1446, 1985.
50.
Tasi, S.C., Adamik, R., Moss, J., Vaughan, M., Manne, V., and Kung, H.F.: Effects of
phospholipids and ADP-ribosylation on GTP hydrolysis by E. coli. H-ras p21. Proc. Natl. Acad.
Sci. USA 82:8310-8314, 1985.
51.
Willumsen, B.W., Papageorge, A.G., Hubbert, N., Bekesi, E., Kung, H.F., and Lowy, D.:
Transforming p21 ras protein: Flexibility in the major variable region linking the catalytic and
membrane anchoring domains. EMBO. J. 4:2893-2896, 1985.
52.
Petska, S., Jung, V., Rashidbaigi, A., Langer, J.A., and Kung, H.F.: Interferon and their receptors.
Proc. on the Ares Serono International Symposium on the Interferon System 24:213-220, 1985.
53.
Rashidbaigi, A., Kung, H.F., and Petska, S.: Binding of 32P-Labeled Human Recombinant
Immune Interferon to U937 Cells. Methods Enzymol. 119:315-321, 1986.
54.
Rashidbaigi, A., Langer, J.A., Jung, V., Jones, C., Morse, H.G., Tischfield, J.A., Trill, J.J., Kung,
H.F., and Pestka, S.: The gene for the human immune interferon receptor is located on
chromosome 6. Proc. Natl. Acad. Sci. USA 83:384-388, 1986.
55.
Kung, H.F., Smith, M.R., Bekesi, E., Manne, V., and Stacey, D.W.: Reversal of transformed
phenotype by monoclonal antibodies against Ha-ras p21 proteins. Exp. Cell Res. 162:363-371,
1986.
56.
Papageorge, A.G., Willumsen, B.M., Johnson, M., Kung, H.F., Stacey, D.W., Vass, W.C., and
Lowy, D.: A transforming ras gene can provide an essential function ordinarily specified by
endogenous ras. Mol. Cell. Biol. 6:1843-1846, 1986.
57.
Halpern, J.L., Tsai, S.C., Adamik, R., Kanaho, Y., Bekesi, E., Kung, H.F., Moss, J., and
Vaughan, M.: Structural and functional characterizations of guanyl nucleotide-binding proteins
using monoclonal antibodies to the -subunit of transducin. Mol. Pharmacol. 29:515-519, 1986.
58.
Willumsen, B.M., Papageorge, A.G., Kung, H.F., Bekesi, E., Robins, T., Johnsen, M., Vass,
W.C., and Lowy, D.R.: Mutational analysis of a ras catalytic domain. Mol. Cell. Biol. 6:26462654, 1986.
59.
Angus, C.W., Van Meurs, K.P., Tsai, S.C., Adamik, R., Chang-Miedel, M., Pan, Y.C.E., Kung,
H.F., Moss, J., and Vaughan, M.: Identification of the probable site of choleragen-catalyzed
ADP-ribosylation in a Go -like protein based on cDNA sequence. Proc. Natl. Acad. Sci. USA
83:5813-5816, 1986.
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Hsiang-fu Kung, Ph.D.
60.
Manne, V. and Kung, H.F.: Characterization of phosphatidylinositol specific phospholipase C
from human platelets. Biochem. J. 243:763-771, 1987.
61.
Stacey, D.W., Watson, T., Kung, H.F., and Curran, T.: Microinjection of transforming ras
protein induces c-fos expression. Mol. Cell. Biol. 7:523-527, 1987.
62.
Deshpande, A.K. and Kung, H.F.: Insulin induction of Xenopus oocyte maturation is inhibited
by monoclonal antibody against p21 ras proteins. Mol. Cell. Biol. 7:1285-1288, 1987.
63.
Van Meurs, K.P., Angus, C.W., Lavu, S., Kung, H.F., Czarnecki, S.K., Moss, J., and Vaughan,
M.: Deduced amino acid sequence of bovine retina Go-: Similarities to other guanyl
nucleotide-binding proteins. Proc. Natl. Acad. Sci. USA 84:3107-3111, 1987.
64.
Honda, S., Asano, T., Kajio, T., Nakagawa, S., Ikeyama, S., Ichimori, Y., Sugino, H., Nara, K.,
Kakinuma, A., and Kung, H.F.: Differential purification by immunoaffinity chromatography of
two carboxy-terminal portion-deleted derivatives of recombinant human interferon- from E.
coli. J. Interferon Res. 7:145-154, 1987.
65.
Willumsen, B.M., Kung, H.F., Johnsen, M., and Lowy, D.R.: A mutation analysis of ras function.
Viral Carcinogenesis 24:385-400, 1987.
66.
Schultz, A.M., Tsai, S.C., Kung, H.F., Oroszlan, S., Moss, J., and Vaughan, M.: Hydroxylaminestable covalent linkage of myristic acid in Go-, a guanine nucleotide-binding protein of bovine
brain. Biochem. Biophys. Res. Commun. 146:1234-1239, 1987.
67.
Lavu, S., Clark, J., Swarup, R., Matsushima, K., Paturu, K., Moss, J., and Kung, H.F.: Molecular
cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go-.
Biochem. Biophys. Res. Commun. 150:811-815, 1988.
68.
Matsushima, K., Kung, H.F., and Copeland, T.: Purification and characterization of a cytosolic
65 KDa phosphoprotein in human leukocytes whose phosphorylation is augmented by
stimulation with interleukin-1. Biochemistry 27:3765-3770, 1988.
69.
Kamata, T. and Kung, H.F.: Effects of ras proteins and PDGF on phospholipid turnover in NRK
cells. Proc. Natl. Acad. Sci. USA 85:5799-5803, 1988.
70.
Matsushima, K., Morishita, K., Yoshimura, T., Lavu, S., Kobayashi, Y., Lew, W., Appella, E.,
Kung, H.F., Leonard, E., and Oppenheim, J.J.: Molecular cloning of a human monocyte derived
neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin-1
and tumor necrosis factor. J. Exp. Med. 167:1833, 1988.
71.
Faltynek, C. and Kung, H.F.: The biochemical mechanisms of action of the interferons.
Biofactors 1:227-235, 1988.
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Hsiang-fu Kung, Ph.D.
72.
Longo, P.A., Broido, M.S., Chen, J., Kung, H.F., and Pincus, M.R.: The structure of the amino
terminal transforming segment of the p21 protein, Tyr4-Thr20 (with Asp12), by two-dimensional
NMR. Biochem. Biophys. Res. Commun. 157:776-782, 1988.
73.
Hseih, J.H., Shih, K.Y., Kung, H.F. et al.: Controlled fed-batch fermentation of recombinant
Saccharomyces cerevisiae to produce hepatitis B surface antigen. Biotechnol. Bioeng. 32:334340, 1988.
74.
Smith, M.R., Ryu, S.H., Suh, P.G., Rhee, S.G., and Kung, H.F.: S-phase induction and
transformation of quiescent NIH/3T3 cells by micro-injection of phospholipase C. Proc. Natl.
Acad. Sci. USA 86:3659-3663, 1989.
75.
Brandt-Rauf, P., Pincus, M., Carty, R., Lubowsky, J., Avitable, M., Kung, H.F., and Maizel, J.:
Conformational effects of amino acid substitutions at position 10, 12 and 13 in the p21 protein. J.
Prot. Chem. 8:79-86, 1989.
76.
Kock, A., Schwarz, T., Urbanski, A., Peng, Z., Vetterlein, M., Micksche, M., Ansel, J.C., Kung,
H.F., and Luger, T.A.: Expression and release of interleukin 1 by different human melanoma cell
lines. JNCI 81:36-41, 1989.
77.
Brown, D., Yu, Z., Miller, P., Blake, K., Wei, C., Kung, H. F., Black, R.J., Tsao, P.O.P., and
Chang, E.H.: Modulation of ras expression by anti-sense, nonionic-deoxyoligonucleotide
analogs. Onocogene Res. 4:243-252, 1989.
78.
Peng, Z., Calvert, I., Clark, J., Helman, L., Kahn, R., and Kung, H.F.: Molecular cloning,
sequence analysis, and mRNA expression of human ADP-ribosylation factor. Biofactors 2:4549, 1989.
79.
Kung, H.F., Calvert, I., Bekesi, E., Khan, F.R. Huang, K.P., Oroszlan, S., Henderson, L.E.,
Copeland, T.D., Sowder, R.C., and Wei, S.J.: Phosphorylation of human interleukin-2 (IL-2).
Mol. Cell. Biochem. 89:29-35, 1989.
80.
Carucci, J.E., Carty, R.P., Chung, D.L., Randall, B.M., Chen, J., Kung, H.F., Nishimura, S.,
Brandt-Rauf, P.W., and Pincus, M.R.: Blocking of the nucleotide exchange of the p21 protein
with the 2', 3'-dialdehyde of guanosine diphosphate, an active site affinity label. Medical Science
Res. 17:559, 1989.
81.
Chen, K., Peng, Z., Lavu, S., and Kung H.F.: Molecular cloning and sequence analysis of two
distinct types of Xenopus laevis protein kinase C. Second Messengers and Phosphoproteins 12:
(No. 5&6), 1989.
82.
Boubik, M., Moschera, J.A., Wei, C., and Kung, H.F.: Conformation and activity of recombinant
human fibroblast interferon. J Interferon Res. 10:213-219, 1990.
83.
Tsai, W.P., Nara, P.L., Kung, H.F., and Oroszlan, S.: Inhibition of human immunodeficiency
virus infectivity by chloroquine. AIDS Res. Hum. Retroviruses 6:481-489, 1990.
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Hsiang-fu Kung, Ph.D.
84.
Smith, M.R., Munger, W.E., Kung, H.F., Takacs, L., and Durum, S.K.: Direct evidence for an
intracellular role for tumor necrosis factor-(TNF): Microinjection of TNF kills target cells. J.
Immunol. 144:162-169, 1990.
85.
Kamata, T. and Kung, H.F.: Modulation of maturation and ribosomal protein S6 phosphorylation
in Xenopus oocytes by microinjection of oncogenic ras protein and protein kinase C. Mol. Cell.
Biol. 10:880-886, 1990.
86.
Smith, M.R., Muegge, K., Keller, J.R., Kung, H.F., Young, H.A., and Durum, S.K.: Direct
evidence for an intracellular role for interferon-: Microinjection of human interferon- induces
Ia expression on murine macrophages. J. Immunol. 144:1777-1782, 1990.
87.
Smith, M.R., Liu, Y.L., Kim H., Rhee, S.G., and Kung, H.F.: Inhibition of serum- and rasstimulated DNA synthesis by antibodies to phospholipase C. Science 247:1074-1077, 1990.
88.
West, M., Kung, H.F., and Kamata, T.: A novel membrane factor stimulates guanine nuelcotide
exchange reaction of ras proteins. FEBS Lett. 259:245-248, 1990.
89.
Smith, M.R., Heidecker, G., Rapp, U.R., and Kung, H.F.: Induction of transformation and
mitogenesis by oncogenic raf proteins. Mol. Cell. Biol. 10:3828-3833, 1990.
90.
Mikovits, J., Raziuddin, Gonda, M., Ruta, M., Lohrey, N., Kung, H.F., and Ruscetti, F.: Negative
regulation of HIV replication in monocytes: Distinctions between restricted and latent expression
in THP-1 cells. J Exp. Med. 171:1705-1720, 1990.
91.
Smith, M.R., Jaramillo, M., Liu, Y., Dever, T.E., Merrick, W.C., Kung, H.F., and Sonenberg, N.:
Translation initiation factors induce DNA synthesis and transform NIH/3T3 cells. New Biologist
2:648-654, 1990.
92.
Huang, Y.K., Kung, H.F., and Kamata, T.: Purification of a novel factor capable of stimulating
guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small
molecular weight G-proteins. Proc. Natl. Acad. Sci. USA 87:8008-8012, 1990.
93.
Lee-Huang, S., Huang, P.L., Nara, P., Chen, H.C., Kung, H.F., Huang, P.H., Huang, H.I., and
Huang, P.L.: MAP 30: A new inhibitor of HIV infection and replication. FEBS Lett. 272:12-18,
1990.
94.
Kovacs, G. and Kung, H.F.: Site-specific, non-homologous chromatide exchange in hereditary
and sporadic renal cell carcinomas. Proc. Natl. Acad. Sci. USA 88:194-198, 1991.
95.
Manne, V., Roberts, D., Tobin, A., O'Rourke, E., De Virgilio, M., Meyers, C., Ahmed, N., Kurz,
B., Resh, M., Kung, H.F., and Barbacid, M.: Identification and preliminary characterization of
farnesyl-protein transferase. Proc. Natl. Acad. Sci. USA 87:7541-7545, 1991.
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Hsiang-fu Kung, Ph.D.
96.
Calvert, I., Kung, H.F., and Raziuddin: Cloning and characterization of a novel sequence specific
DNA-binding protein recognizing the negative regulatory region element (NRE) of HIV-l long
terminal repeat. Gene 101:171-176, 1991.
97.
Kovacs, G., Fuzesi, L., Emanuel, A., and Kung, H.F.: Cytogeneties of papillary renal cell tumors.
Genes, Chromosomes and Cancer 3:249-235, 1991.
98.
Kovacs, G., Emanuel, A., Neumann, H.P.H., and Kung, H.F.: Cytogenetics of renal cell
carcinomas associated with Von Hippel Lindau disease. Genes, Chromosomes and Cancer
3:256-262, 1991.
99.
Lee-Huang, S., Huang, P.L., Kung, H.F., Li, B.Q., Huang, P.L., Huang, P., Huang, H.I., and
Chen, H.C.: TAP 29: An anti-human immunodeficiency virus protein from Trichosanthes
kirilowii that is nontoxic to intact cells. Proc. Nati. Acad. Sci. USA 88:6570-6574, 1991.
100.
Ono, M., Kuwano, M., and Kung, H.F.: Malignant transformation of mouse Balb/3T3 cells by
polyoma middle T antigen requires epidermal growth factor receptor expression. Cell Growth &
Differentiation 2:317-322, 1991.
101.
Smith, M.R., Jaramillo, M., Tuazon, P.T., Traugh, J.A., Liu, Y.L., Sonenberg, N., and Kung,
H.F.: Modulation of the mitogenic activity of eukaryotic translational initiation factor 4E by
protein kinase C. New Biologist 3:601-607, 1991.
102.
Raziuddin, Mikovits, J., Calvert, I., Ghosh, S., Kung, H.F., and Ruscetti, F.: Negative regulation
of chronic low-level HIV-l expression in monocytes: Involvement of the 65 + 50 kDa NF-B
heterotetramer. Proc. Natl. Acad. Sci. USA 88:9426-9430, 1991.
103.
Lee-Huang, S., Kung, H.F., Huang, P.L., Huang, P.L., Li, B.Q., Huang, P., Huang, H.I., and
Chen, H.C.: A new class of anti-HIV agents: GAP 31, DAPs 30 and 32. FEBS Lett. 291:139144, 1991.
104.
Chuang, L.F., Kung, H.F., Israel, M., and Chuang, R.Y.: Activation of human leukemia protein
kinase C by tumor promoters and its inhibition by N-trifluroacetyl-adriamycin -14- valerate
(AD32). Biochem. Pharmacol. 43:865-872, 1992.
105.
Kovacs, G., Kiechle-Schwarz, M., Scherer, G., and Kung, H.F.: Molecular analysis of the
chromosome 1lp region in renal cell carcinoma. Cell. Mol. Biol. 38:59-62, 1992.
106.
Tsai, W.P., Hirose, K., Nara, P.L., Kuang, Y.D., Conley, S., Li, B.Q., Kung, H.F., and
Matsushima, K.: Decreased cytokine production by macrophages persistently infected with HIV.
Lymphokine and Cytokine Research 10:421-429, 1991.
107.
Fenton, R.G., Kung, H.F., Longo, D.L., and Smith, M.R.: Regulation of intracellular actin
polymerization by farnesylated cellular proteins. J. Cell Biol. 117:347-356, 1992.
10
Hsiang-fu Kung, Ph.D.
108.
Li, B.Q., Kaplan, D., Kung, H.F., and Kamata, T.: Stimulation by NGF of both the ras-guanine
nucleotide exchange factor and GAP activities in PC12 cells. Science 256:1456-1459,1992.
109. Seguchi, T., Goto, Y., Ono, M., Fujiwara, T., Shimada, T., Kung, H.F., Nishioka, M., Ikehara, Y.,
and Kuwano, M.: Brefeldin A-resistant mutants of human epidermoid carcinoma cell line with
structural changes of the Golgi Apparatus. J. Biol. Chem. 267:11626-11630, 1992.
110.
Smith, M.R., Ramsburg, E.A., Kung, H.F., and Durum, S.K.: Components of the protein kinase
C pathway induces Ia expression after injection into macrophages. J. Immunol. 149:1304-1310,
1992.
111.
Tsai, W.P, Kung, H.F., Goudsmit, J., Rimmelzwaan, G., Minassian, A., Garrity, R., and Nara, P:
HIV-1 Tropism: Truth or Consequences? AIDS Res. Hum. Retroviruses 8:1749-1750, 1992.
112.
Nara, P., Tsai, W.P., Kung, H.F., Minassian, A., and Garrity, R.: Universal cellular tropism?
Nature 360:215-216, 1992.
113.
Huang, P.L., Chen, H.C., Kung, H.F., Huang, P.L., Huang, P., Huang, H.I., and Lee-Huang, S.:
Anti-HIV plant proteins posses a unique ATP-Independent DNA topoisomerase II activity.
Biofactors 4:37-41, 1992.
114.
Maeno, M., Ong, R., and Kung, H.F.: Positive and negative regulation of the differentiation of
ventral mesoderm for erythrocytes in Xenopus laevis. Development, Growth, and Differentiation.
34:567-577, 1992.
115.
Lazaris-Karatzas, A., Smith, M.R., Frederickson, R.M., Jaramillo, M.L., Liu, Y.L., Kung, H.F.,
and Sonenberg, N.: Ras mediates translation factor 4E induced oncogenic transformation. Genes
& Dev. 6:1631-1642, 1992.
116.
West, M., Mikovits, J., Princler, G., Liu, Y.L., Ruscetti, F.W., Kung, H.F., and Raziuddin:
Characterization and purification of a novel transcriptional repressor from Hela cell nuclear
extracts recognizing the negative regulatory element (NRE) region of HIV-1 long terminal repeat.
J. Biol. Chem. 267:24948-24952, 1992.
117.
Gopas, J., Ono, M., Princler, G.L., Smith, M.R., Tainsky, M.A., Siddiqui, M.A.Q., Wishniak, O.,
Segal, S., Kuwano, M., and Kung, H.F.: EGF receptor and mitogenic response of BALB/3T3
cells expressing Ras and Myc oncogenes. Cell. Mol. Biol. 38:605-614, 1992.
118.
Ong, R., Maeno, M., and Kung, H.F.: Murine stem cell factor stimulates erythropoietic
differentiation of ventral mesoderm in Xenopus gastrula embryo. Exp. Cell Res. 205:326-330,
1993.
119.
Lee-Huang, S., Lin, J.J., Kung, H.F., Huang, P.L., Lee, L., and Huang, P.L.: The human
erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional
regulatory elements in its 5'-flanking region. Gene 128:227-236, 1993.
11
Hsiang-fu Kung, Ph.D.
120.
Li, B.Q., Fu, T., Yan, Y.D., Baylor, N.W., Ruscetti, F.W., and Kung, H.F.: Inhibition of HIV
infection by baicalin-a flavonoid compound purified from Chinese herbal medicine. Cell. Mol.
Biol. Res. 39:119-124, 1993.
121.
Ono, M., Nakayama, Y., Princler, G., Gopas, J., Kung, H.F., and Kuwano, M.: Polyoma middle
T antigen or v-Src desensitize human epidermal growth factor receptor function and interference
by a monensin-resistant mutation in mouse Balb/3T3 cells. Exp. Cell Res. 203:456-465, 1992.
122.
Smith, M.R., Matthews, N., Jones, K., and Kung, H.F.: Biological actions of oncogenes.
Pharmacol. Ther. 58:211-236, 1993.
123.
Li, B.Q., Subleski, M., Shalloway, D., Kung, H.F., and Kamata, T.: Mitogenic activation of the
Ras guanine nucleotide exchange factor in NIH/3T3 cells involves protein tyrosine
phosphoiylation. Proc. Natl. Acad. Sci. USA 90:8504-8508, 1993.
124.
Maeno, M., Xue, Y., Wood, T.I., Ong, R.C., and Kung, H.F.: Cloning and expression of cDNA
encoding Xenopus laevis bone morphogenetic protein-1 during early embryonic development.
Gene 134: 257-261, 1993.
125.
Lee-Huang, S., Lin, J.J., Kung, H.F., Huang, P.L., Lee, L., and Huang, P.L.: The 3'-flanking
region of the human erythropoietin-encoding gene contains nitrogen regulatory/oxygen-sensing
consensus sequences and tissue-specific transcriptional regulatory elements. Gene 137: 203-209,
1993.
126.
Maeno, M., Ong, R.C., Xue, Y., Nishimatsu, S., Ueno, N., and Kung, H.F.: Regulation of
primary erythropoiesis in the ventral mesoderm of Xenopus gastrula embryo: Evidence for the
expression of a stimulatory factor(s) in animal pole tissue. Dev. Biol. 161:522-529, 1994.
127.
Schwabe, M., Zhao, J., and Kung, H.F.: Differential expression and modulation by its ligand of
the human interleukin-6 receptor on interleukin-6-responsive cells. J. Biol. Chem. 269:72017209, 1994.
128. Sarkar, F.H., Smith, M.R., Hoover, T., Princler, G., Crissman, J.D., Visscher, D.W., Longo, D.L.,
Kung, H.-F., and Raziuddin: A c-erbB2 promoter specific DNA-binding protein isolated from
human breast cancer tissues displays mitogenic activity. J Biol. Chem. 269:12285-12289, 1994.
129.
Lee-Huang, S., Kung, H.F., Chen, H.C., Huang, P.L., Rybak, S., Huang, P.L., Bourinbaiar, A.S.,
and Liaw, Y.C.: Crystallization and preliminary X-ray analysis of GAP 31, an anti-HIV protein.
J. Mol. Biol. 240:92-94, 1994.
130.
Chuang, L.F., Chuang, T.K., Killam, K.F., Chuang, A.J., Kung, H.F., Yu, L., and Chuang, R.Y.:
Delta opioid receptor gene expression in lymphocytes. Biochem. Biophys. Res. Commun.
202:1291-1299, 1994.
12
Hsiang-fu Kung, Ph.D.
131.
Smith, M.R., Liu, Y.L., Matthews, N.T., Rhee, S.G., Sung, W.K. and Kung, H.F.: Phospholipase
C-l can induce DNA synthesis by a mechanism independent of its lipase activity. Proc. Natl.
Acad. Sci. USA 91:6554-6558, 1994.
132.
Zhao, J. and Kung, H.F.: Modulation of progesterone-induced Xenopus oocyte maturation by
prostaglandins El and E2. Cell Mol. Biol. Res. 40:63-68, 1994.
133.
Lin, J.J., Newton, D., Mikulski, S., Ardelt, W., Kung, H.F., Youle, R. and Rybak, S.:
Characterization of the mechanism of cellular and cell-free protein synthesis inhibition by an
anti-tumor ribonuclease. Biochem., Biophys. Res. Commun. 294:156-162, 1994.
134.
Rybak, S., Lin, J.J., Newton, D., Kung, H.F., Monks, A., Chen, H.C., Huang, P.L., and LeeHuang, S.: In vitro anti-tumor activity of the anti-HIV agents MAP30 and GAP31. Int. J.
Oncology 5:1171-1176, 1994.
135.
Maeno, M., Ong, R.C., Suzuki, A., Ueno, N. and Kung, H.F.: A truncated bone morphogenetic
protein-4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: Roles of animal pole
tissue in the development of ventral mesoderm. Proc. Natl. Acad. Sci. USA 91:10260-10264,
1994.
136.
Zhao, J., Kung, H.F., and Manne, V.: Farnesylation of p21 RAS proteins in Xenopus oocytes.
Cellular and Molecular Biology Res. 40:313-321, 1994.
137.
Lee-Huang, S., Kung, H.F., Huang, P.L., Bourinbaiar, A.S., Morell, J.L. Brown, J.H., Huang,
P.L., Tsai, W.P., Chen, A.Y., Huang, H.I., and Chen, H.C.: Human immunodeficiency virus type
1 (HIV-1) inhibition, DNA-binding, RNA-binding, and ribosome inactivation activities in the Nterminal segments of the plant anti-HIV protein GAP31. Proc. Natl. Acad. Sci. USA 91:1220812212, 1994.
138.
lzumi, H., Ono, M., Ushiro, S., Kohno, K., Kung, H.-F., and Kuwano, M.: Cross talk of tumor
necrosis factor- and epidermal growth factor in human microvascular endothelial cells. Exp.
Cell Res. 214:654-662, 1994.
139.
Chuang, L.F., Blackbourn, D.J., Chuang, A.J., Killam, K.F., Jr., Liu, X., Li, Y., Kung, H.-F., and
Chuang, R.Y.: Emergence of antigenic variants of simian immunodeficiency virus (SlVmac) in a
seronegative Macaque after SlVmac239 infection. Cell. and Mol. Biol. Res. 40:661-669, 1994.
140.
Schwabe, M., Brini, A.T., Bosco, M.C., Rubboli, F., Egawa, M., Zhao, J., Princler, G.L., and
Kung, H.F.: Disruption by IFN- of an autocrine IL-6 growth loop in IL-6-dependent U266
myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor - and chains. J Clin. Invest. 94:2317-2325, 1994.
141.
Egawa, M., Maeno, M., Kung, H.-F., and Schwabe, M.: Expression of the human interleukin 6
receptor -chain in Xenopus laevis oocytes. Cytokine 7:83-88, 1995.
13
Hsiang-fu Kung, Ph.D.
142.
Chuang, L.F., Chuang, T.K., Killam, K.F., Jr., Qiu, Q., Wang, X.R., Lin, J.-J., Kung, H.-F.,
Sheng, W., Chao, C., Yu, L., and Chuang, R.Y.: Expression of kappa opioid receptors in human
and monkey lymphocytes. BBRC 209:1003-1010, 1995.
143.
Lee-Huang, S., Huang, P.L., Huang, P.L., Bourinbaiar, A.S., Chen, A.Y., and Chen, H.C., Kung,
H.F.: Inhibition of human immunodeficiency virus type 1 (HIV-1) integrase by anti-HIV plant
proteins MAP30 and GAP31. PNAS 92:8818-8822, 1995.
144.
Xu, R.-H., Kim, J., Taira, M., Zhan, S., Sredni, D., and Kung, H.-F.: A dominant negative bone
morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm. BBRC 212:212-219,
1995.
145. Lee-Huang, S., Huang, P.L., Chen, H.-C., Huang, P.L., Bourinbaiar, A.S., Huang, H.I., and Kung,
H.-F.: Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon. Gene
161:151-156, 1995.
146.
Smith, M.R., Liu, Y.L., Rhee, S.G., and Kung, H.F.: Phospholipase C signalling. Zoological
Studies 34:141-148, 1995.
147.
Jones, T.L., Karavanov, I., Maeno, M., Ong, R.C., Kung, H.F., and Daar, I.O.: An amphibian
homolog of the EPH family of receptor tyrosine kinases is developmentally regulated. Oncogene
10:1111-1117, 1995.
148. Kumar, C.C., Rogers, C.P., Kelley, J., Meyer, S., Dong, Z., Lin, J.-J., Armstrong, L., Kung, H.-F.,
Weber, M.J., and Alfonso, A. SCH 51344 inhibits Ras-transformation by a novel mechanism.
Cancer Res. 55:5106-5117, 1995.
149.
West, M., Hoover, T., Kung, H.-F. and Raziuddin: Tat mediates transcriptional activation of
HIV-1 gene in vitro. Indian J. Biochem. & Biophys. 32:351-355, 1995.
150.
Li, B.-Q., Wang, M.-H., Kung, H.-F., Ronsin, C., Breathnach, R., Leonard, E.J., and Kamata, T.:
Macrophage-stimulating protein activates ras by both activation and translocation of SOS
guanine nucleotide exchange factor. Biochem. Biophys. Res. Commun. 216:110-118, 1995.
151.
Schwabe, M., Cox, G.W., Bosco, M.C., Prohaska, R. and Kung, H.-F.: Multiple cytokines inhibit
Interleukin-6-dependent murine hydridoma/plasmacytoma proliferation. Cell. Immun. 168:117121, 1996.
152.
Xu, R.-H., Dong, Z., Maeno, M., Kim, J., Ueno, N., Sredni, D., Colburn, N.H. and Kung, H.-F.:
Involvement of ras/raf/AP-1 in BMP-4 signaling during Xenopus embryonic development. Proc.
Natl. Acad. Sci. USA 93:834-838, 1996.
153.
Li, B.-Q., Subleski, M., Fusaki, N., Yamamoto, T., Copeland, T., Princler, G.L., Kung, H.-K.,
and Kamata, T.: Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated
by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells. Proc. Natl. Acad. Sci.
USA 93:1001-1005, 1996.
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Hsiang-fu Kung, Ph.D.
154.
Dong, Z., Xu, R.-H.' Kim, J, Zhan, S.-N., Ma, W.-Y., Colburn, N.H. and Kung, H.-F.: AP-1/jun
is required for early Xenopus development and mediates mesoderm induction by FGF but not by
Activin. J. Biol. Chem. 271:9942-9946, 1996.
155.
Smith, M.R., Liu, Y., Kim, S.R., Bae, Y.S., Kim, C.G., Kwon, K., Rhee, S.G., and Kung, H.-F.:
PLCl Src homology domain induces mitogenesis in quiescent NIH 3T3 fibroblasts. Biochem.
Biophys. Res. Comm., 222:186-193, 1996.
156.
Okimoto, T., Kohno, K., Kuwano, M., Gopas, J., Kung, H.-F., and Ono, M.: Regulation of
epideimal growth factor receptor by activated H-ras and V-myc oncogenes in mouse Balb/3T3
cells: possible roles of AP-1. Oncogene 12:1625-1633, 1996.
157.
Hoover, T., Mikovits, J., Court, D., Liu, Y.-L., Kung, H.F. and Raziuddin.. A nuclear matrixspecific factor that binds a specific segment of the negative regulatory element (NRE) of HIV-1
LTR and inhibits NF-B activity. Nucleic Acids Res. 24:1895-1900, 1996.
158.
Maeno, M., Mead, P.E., Kelley, C., Xu, R.-H., Kung, H.-F., Suzuki, A., Ueno, N. and Zon, L.I.
The role of BMP-4 and GATA-2 in the induction and differentiation of hemotopoietic mesoderm
in Xenopus laevis. Blood 88:1965-1972, 1996.
159.
Rybak, S.M., Pearson, J.W., Fogler, W.E., Volker, K., Spence, S.E., Newton, D.L., Mikulski,
S.M., Ardelt, W., Riggs, C., Kung, H.F., and Longo, D.L.: Enhancement of vincristine
cytotoxicity in drug-resistant cells by simultaneous treatment with Onconase, an anti-tumor
ribonuclease. J. Natl. Cancer Inst. 88:747-753, 1996.
160.
Newton, D.N., Pearson, J.W., Xue, Y., Smith, M.R., Fogler, W., Mikulski, S.M., Alvord, G.W.,
Kung, H.F., Longo, D.L., and Rybak, S.M.: Anti-tumor ribonuclease, combined with or
conjugated to monoclonal antibody MRK16, overcomes multi-drug resistance to Vincristine in
vitro and in vivo. Intl. J Oncology 8:1095-1104, 1996.
161.
Xu, R.-H., Kalechman, Y., Albeck, M., Kung, H.-F., and Sredni, B. Inhibition of B16 melanoma
metastasis by the immunomodulator AS 101. Intl. J. Oncology 9:319-325, 1996.
162.
Bian, J., Wang, Y., Smith, M.R., Kim, H., Jacobs, C., Jackman, J., Kung, H.-F., Colburn, N.H.,
and Sun, Y. Suppression of the in vivo tumor growth and induction of suspension cell death by
tissue inhibitor of metalloproteinases (TIMP-3). Carcinogenesis 17:1805-1811, 1996.
163.
Tsai, W.P., Conley, S., Kung, H.F., Garrity, R., and Nara, P.: Preliminary in vitro growth cycle
and transmission studies of HIV-1 in an autologous primary cell assay of blood-derived
macrophages and peripheral blood mononuclear cells. Virology 226:206-16, 1996.
164.
Schwabe, M., Deryugina, E.I., Bosco, M.C., Gusella, G.L., Reinisch, W., Kung, H.F., and
Bourdon, MA. IL-6 Signals inhibition of cell-adhesion in melanoma A375-C6. Anticancer Res.
16:3363-3370, 1996.
15
Hsiang-fu Kung, Ph.D.
165.
Xu, R.-H., Kim, J., Taira, M., Lin, J.-J., Zhang, C.-H., Sredni, D., Evans, T. and Kung, H.-F.
Differential regulation of neurogenesis by the two Xenopus GATA-1 genes. Mole. Cell. Biol.
17:436-443, 1997.
166.
Lin, J.-J., Maeda, R., Ong, R.C., Kim, J., Lee, L.M., Kung, H.-F., Maeno, M. XBMP-IB (Xtld), a
Xenopus homolog of dorso-ventral polarity gene in Drosophila, modifies tissue phenotypes of
the ventral explants. Dev. Growth & Diff.39:43-51,1997.
167.
Xu, R-H., Kim, J., Taira, M., Sredni, M. and Kung, H-F. Studies on the role of fibroblast growth
factor signaling in neurogenesis using conjugated/aged animal caps and dorsal ectoderm-grafted
embryos. J. Neurosci. 17:6892-6898, 1997.
168.
Maeda, R., Kobayashi, A., Sekine, R., Lin, J.J., Kung, H., and Maeno, M. Xmsx-1 modifies
mesodermal tissue pattern along dorsoventral axis in Xenopus laevis embryo. Development
124:2553-2560, 1997.
169.
Newton, D.L., Xue, Y., Boque, L., Wlodawer, A., Kung, H.-F. and Rybak, S. Expression and
characterization of a cytotoxic human-frog chimeric ribonuclease: Potential for cancer therapy.
Protein Engineering 10:463-470, 1997.
170.
Choudhury, B.K., Andrews, M.T., Kim, J., Kung, H.F. and Li, S.S.-L. Cloning and
developmental expression of Xenopus cDNAs encoding the enhancer of split groucho and related
proteins. Gene 195:41-48, 1997.
171.
Lin, M.C.M., Ji, J-J., Wang, E-J., Princler, G.L., Kauffman, F.C., and Kung, H-F. Ethanol down
regulates the trancscription of microsomal triglyceride transfer protein gene. FASEB J. 11:
1145-1152, 1997.
172.
Raziuddin, A., Court, D., Sarkar, F.H., Liu, Y-L., Kung, H-F., and Raziuddin, R. A c-erbB-2
promoter-specific nuclear matrix protein from human breast tumor tissues mediates NF-B
DNA-binding activity. J Biol. Chem. 272:15715-15720, 1997.
173.
Tsai, W.P., Rimelzwaan, G.F., Merges, M.J., Wu, S.-C., Conley, S., Kung, H.-F., Garrity, R.,
Goudsmit, J., and Nara, P.: Preliminary findings of an in vitro human spleen mononuclear cell
culture system for primary isolates of HIV type 1. AIDS Res. Hum. Retroviruses 13:967-977,
1997.
174.
Smith, M.R., Court, D.W., Kim, H-K., Park, J-B., Rhee, S.G., Rhim, J.S. and Kung, H.F.
Overexpression of PLC in murine fibroblasts promotes transformation and tumorigenecity.
Carcinogenesis 19:101-109, 1997.
175.
Smith, M.R., Wilson, M.L., Hamanaka, R., Chase, D., Kung, H-F., Longo, D.L., and Ferris, D.K.
Malignant transformation of mammalian cells initiated by consitutive expression of the Polo-like
kinase. BBRC 234: 397-405, 1997.
16
Hsiang-fu Kung, Ph.D.
176.
Chen, Z., Fisher, R.J., Li, B-Q., Kamata, T., Kung, H-F., Lautenberger, J.A. and Rhim, J.S.
Elevated expression of ETS-1 gene in a metastatic tumorigenic human prostate epithelial cell
line transformed by the v-Ki-ras oncogene. Intl. J Oncology 11:1179-1184, 1997.
177.
Ault, K.T., Xu, R.-H., Kung, H.-F., and Jamrich, M. The homeobox gene PV.1 mediates
specification of the prospective neural ectoderm in Xenopus embryos. Developmental Biology
192:162-171, 1997.
178.
Rhim, J.S. and Kung, H.F. Human prostate carcinogenesis.
Oncogenesis 8:305-328, 1997.
179.
Smith, M.R., Colburn, N.H., Kung, H-F., and Sun, Y. TIMP-3 expression induces apoptosis by
restoring TNF receptors to the surface of human colon carcinoma cells. Cytokine 9:770-780,
1997.
180.
Kim, J., Lin, J-J., Xu, R-H. and Kung, H-F. Mesoderm induction by Heterodimer AP-1 (c-Jun
and c-Fos) and its involvement in mesoderm formation through Xbra/eFGF autocatalytic loop
during the early development of Xenopus embryos. J. Biol. Chem. 273:1542-1550, 1998.
181.
Kamata, T., Subleski, M., Hara, Y., Yuhki, N., Kung, H-F., Copeland, N.G., Jenkins, N.A.,
Yoshimura, T., Modi, W., and Copeland, T.D. Isolation and characterization of a neural specific
protein (NSP60) gene homologous to C. elegans unc-33 controlling axonal outgrowth and
guidance. Mol. Brain Res. 54:219-236, 1998.
182.
Jones, T.L., Kim, J., Xu, R-H., Chong, L.D., Kung, H-F., and Daar, I.O. Loss of cell adhesion in
Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, and Eph ligand. Proc.
Natl. Acad. Sci. USA 95:576-581, 1998.
183.
Kamata, T., Subleski, M., Copeland, T., Kung, H.F., and Xu, R.H. Xenopus CRMP-2 is an early
response gene to neural induction. Molecular Brain Res. 57:201-210, 1998.
184.
Smith, M.R., Court, D.W., Kim, H-K., Park, J-B., Rhee, S.G., Rhim, J.S. and Kung, H.F.
Overexpression of PLC in NIH 3T3 cells promotes transformation and tumorigenecity.
Carcinogenesis 19:177-185, 1998.
185.
Kim, J., Ault, K.A., Chen, H-D., Xu, R-H., Rob, D-H., Lin, M.C., Park, M-J., Kung, H-F.,
Transcriptional Regulation of BMP-4 in the Xenopus Embryo; Analysis of Genomic BMP-4 and
its Promoter. BBRC 250:516-530, 1998.
186.
Chen, H-D., Chen, C-L., Huang, S-W., Kung, H-F., Chen, H-C. Characterization of latex
components by capillary zone electrophoresis and N-terminal sequence. J. Biomed. Sci. 5:421427, 1998.
187.
Burger, A.M., Fiebig, H.H., Kuettel, M.R., Lautenberger, J.A., Kung, H.F., Rhim, J.S. Effect of
oncogene expression on telomerase activation and telomere length in human endothelial,
fibroblast and prostate epithelial cells. Int. J. Oncol. 13(5):1043-8, November 1998.
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Hsiang-fu Kung, Ph.D.
188.
Chung, D., Villafania, A., Anwar, K., Amar, S., Rijwani, K., Kung, H.F., Adler, V., Ronai, Z.,
Brandt-Rauf, P.W., Yamaizumi, Z. and Pincus, M.R. Mutual dependence of jun-N-Terminal
kinase and protein kinase C on the oncogenic ras-p21 protein-induced mitogenic signaling
pathway. Med. Sci. Res. 26, 147-150, 1998.
189.
Villafania, A., Anwar, K., Amar, S., Chung, D., Adler, V., Ronai, Z., Brandt-Rauf, P.W.,
Yamaizumi, Z., Kung, H.F. and Pincus, M.R. Glutathione-S transferase as a selective inhibitor
of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by
jun-N-Terminal kinase. Ann. Clin. Lab. Sci. 30, 61-68, 1999.
190.
Tsai, W.P., Kung, H.F., and Nara, P. The Presence and absence of histocompatibility antigens in
HIV-1 produced by autologous blood-derived macrophages and peripheral blood lymphoblasts.
AIDS Res. Hum. Retroviruses 15:33-41, 1999.
191.
Xu, R.H., Ault, K.T., Kim, J. Park, M.J. Hwang, Y.S., Peng, Y., Sredni, D., and Kung, H.F.
Opposite effects of FGF and BMP-4 on embryonic blood formation: Roles of PV1 and GATA 2.
Dev. Biol. 208:352-361, 1999.
192.
Lee-Huang, S., Huang, P., Sun, Y., Huang, P.L., Kung, H.F., Blithe, D.L. and Chen, H.C.
Lysozyme and ribonucleases as anti-HIV components in beta-core preparation of hCG. PNAS
96:2678-2681, 1999.
193.
Xu, R.H., Lechleider, R.J., Shih, H.M., Hao, C.F., Sredni, D., Roberts, A.B., Kung, H.F.
Functional analysis of human smad 1: role of the amino-terminal domain. BBRC 258(2):366-73,
May 10, 1999.
194.
Ishimura, A., Princler, G.L., Lin, J-J., Kung, H-F., and Maeno, M. Immunodetection of Xenopus
bone morphogenetic protein-1 in adult and embryonic cells. Growth Factor, 16(3):171-177,
1999.
195.
Peehl, D.M., Sellers, R.G., Arnstein, P., Kung, H.F. and Rhim, J.S. Altered growth regulation
and loss of response to retinoic acid accompany tumorigenic transformation of prostatic cells.
Anti-Cancer Research 19:3857-3864, 1999.
196.
Huang, P.L, Sun Y., Chen H-C., Kung, H.F. Huang, P.L. and Lee-Huang, S. Proteolytic
fragments of anti-HIV and anti-tumor proteins MAP30 AND GAP31 are biologically active.
BBRC 262:615-623, 1999.
197.
Choi, Y., Chuang, L.F., Lam, K.M., Kung, H.F., Wang J.M., Osburn, B.I., and Chuang, R.Y.
Inhibition of chemokine-induced chemotaxis of monkey leukocytes by mu-opioid receptor
agonists, In Vivo, 13:389-396, 1999.
198.
Hukku, B., Mally, M., Cher, M.L., Peehl, D.M., Kung, H.F. and Rhim, J.S. Stepwise genetic
changes associated with progression of nontumorigenic HPV-18 immortalized human prostate
cancer-derived cell line to a malignant phenotype. Cancer Genet Cytogenet 120:117-126, 2000.
18
Hsiang-fu Kung, Ph.D.
199.
Lee-Huang, S., Huang, P.L., Sun, Y., Chen, H-C., Kung, H.F., Huang, P.L. and Murphy, W.J.
Inhibition of MDA-MB-231 human breast tumor xenografts and HER 2 expression by anti-tumor
agents GAP31 and MAP30. Anti-Cancer Research 20:653, 2000.
200.
Jin, D.Y., Wang, H.L., Zhou, Y., Chun, C.S., Kibler, K., Hou, Y.D., Kung, H.F., and Jeang, K.T.
Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular
transformation. The EMBO Journal, 19(4):729-740, 2000.
201.
Kim J., Lee H-S., Roh, D-H., Hwang, Y.-S., Xu, R.-H., Kung, H.-f., Bae, Y.-C., and Mae-Ja Park.
Transcriptional regulation of the Xbr-1a/Xvent-2 gene by BMP-4 signaling during Xenopus
embryonic development. Korean J. Anatomy 33:595-608, 2000
202.
Miyagi, T., Chuang, L.F., Lam, K.M., Kung, H.F., Wang, J.M., Osburn B.I., and Chuang, R.Y.
Opioids suppress chemokine-mediated migration of monkey neutrophils and monocytes - an
instant response. J. Immunopharmacology, 47(1):53-62, 2000.
203.
Xu, R.H., Peng, Y., Fan, J., Yan, D., Yamagoe, S., Princler, G., Sredni, D., Ozato, K., and Kung,
H.F. Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction. Dev. Dyn.,
218(4):628-635, 2000.
204.
Sekowska, A., Kung, H.F., and Danchin, A. Sulfur metabolism in Escherichia coli and related
bacteria, facts and fiction. J. Mol. Microbio Biotech. 2(2):145-177, 2000.
205.
Chun, A.C.S., Zhou, Y., Wong, C.M., Kung, H.F., Jeang, K.T., and Jin, D.Y. Coiled-coil motif
as a structural basis for the interaction of HTLV-1 tax with cellular co-factors. AIDS Res. Hum.
Retroviruses, 16(16):1689-1694, 2000.
206.
Shao, W., Lee, A.Y., Gulnik, S., Gustchina, E., Liu, Y.L., Kung, H.F., and Erickson, J.W. A
novel putative transcription factor protein p44 (MYT2) that preferentially binds supercoiled
DNA and induces DNA synthesis in quiescent cells. FEBS Lett. 473:363-369, 2000.
207.
Zhou, Y., Kok, K.H., Chun, A.C.S., Wong, C.M., Wu, H.W., Lin, M.C.M., Fung, P.C.W., Kung,
H.F., and Jin D.Y. Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced
apoptosis. Biochem. & Biophysical Res. Comm. 268:921-927, 2000.
208.
Villafania, A., Anwar, K., Amar, S., Chie, L., Way, D., Chung, D.L., Adler, V., Ronai, Z.,
Brandt-Rauf, P.W., Yamaizumii, Z., Kung, H.F., & Pincus, M.R. Glutathione-S-Transferase as a
selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of
activation of jun by jun-N-terminal kinase. Ann Clin Lab Sci., 30(1):57-64, 2000.
209.
Chen, H.D., Huang, Y.K., Ault, K., Wong, G.W., Lin, M.C.M., Chen, H.C. and Kung, H.F.
Molecular basis for differing anti-neurogenic effects of Gata-1a and Gata-1b in Xenopus.
Biochem. & Biophysical Res. Comm. 273:614-620, 2000.
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Hsiang-fu Kung, Ph.D.
210.
Liu, W.D., Ren, C.P., Shi, J.L., Feng, X.L., He, Z.W., Xu, L.G., Lan, K., Xie, L., Peng, Y., Fan,
J., Kung, H.F., Yao, K.T. and Xu, R.H. Characterization of the functionally related sites in the
neural inducing gene noggin. Biochem. & Biophysical Res. Comm. 270:293-297, 2000.
211.
Jiang, X.H., Wong, B.C.Y., Jiang, S.H., Yuen, S.T., Cho, C.H., Lai, K.C., Lin, M.C.M., Kung,
H.F. and Lam, S.K. Arsenic trioxide induces apoptosis in human gastric cancer cells through
upregulation of p53 and activation of caspase 3. International Journal of Cancer, 91:173-179,
2001.
212.
Wong, C.M., Chun, A.C.S., Kok, K.H., Zhou, Y., Fung, P.C.W., Kung, H.F., Jeang, K.T. and Jin
D.Y. Characterization of human and mouse peroxiredoxin IV: evidence for inhibition by Prx-IV
of epidermal growth factor- and p53-induced reactive oxygen species. Antioxidants & Redox
Signaling, 2(3):507-518, 2000.
213.
Peng, Y., Kok, K.H., Xu, R.H., Kwok, K.H.H., Tay, D., Fung, P.C.W., Kung, H.F. and Lin,
M.C.M. Maternal cold inducible RNA binding protein is required for embryonic kidney
formation in Xenopus laevis. FEBS Let. 482:37-43, 2000.
214.
Chie, L., Amar, S., Kung, H.F., Lin, M.C.M., Yamaizumi, Z., Michl, J., and Pincus, M.R.
Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21
pathway is dependent on the raf-MEK signal transduction pathway. Cancer Chemother.
Pharmacol. 45(6):441-449, 2000.
215.
Duan, H., Tsvetkov, L.M., Liu, Y., Song, Y., Swaroop, M., Wen, R., Kung, H.F., Zhang, H. and
Sun, Y. Promotion of the S-phase entry and cell growth under serum starvation by
SAG/ROC2/Rbx2/Hrt2, and E3 ubiquitin ligase component: Association with inhibition of p27
accumulation. Molecular Carcinogenesis, 30(1):37-46, 2001.
216.
Lau, G.T.C., Wong, O.G.W., Chan, P.M.Y., Kok, K.H., Wong, R.L.Y., Chin, K.T., Lin, M.C.M.,
Kung, H.F. and Chow, K.L. Embryonic XMab2112 expression is required for gastrulation and
subsequent neural development. Biochem. & Biophysical Res. Comm. 280, 1378-1384, 2001.
217.
Li, B-Q., Fu, T., Gong, W-H., Kung, H.F., Kang, J., Yan Y., Howard, O.M.Z. and Wang, J.M.
The flavonoid baicalin exhibits anti-inflammatory activity by selectively binding to chemokines.
Immunopharmacology, 49(3):295-306, 2000.
218.
Jiang, X.H., Wong, B.C.Y., Lin, M.C.M., Zhu, G.H., Kung, H.F. Jiang, S.H., Yang, D., and Lam,
S.K. Functional p53 is required for Triptolide-induced apoptosis and AP-1 and Nuclear FactorkB activation in Gastric cancer cells. Oncogene, 20(55):8009-8018, 2001.
219.
Zhou, X.M., Wong, B.C.Y., Fan, X.M., Zhang, H.B., Lin, M.C.M., Kung, H.F., Fan, D.M., Lam,
S.K. Non-steroidal antiinflammatory drugs induced apoptosis in gastric cancer cells through upregulation of bax and bak. Carcinogenesis, 22(9):1393-97, 2001.
20
Hsiang-fu Kung, Ph.D.
220.
Wong, B.C.Y., Wang, W.P., Cho, C.H., Fan, X.M., Lin, M.C.M., Kung, H.F. and Lam, S.K. 12Lipoxygenase inhibition induced apoptosis in human gastric cancer cells. Carcinogenesis,
22(9):1349-54, 2001.
221.
Fan, X.M., Wong, B.C.Y., Lin, M.C.M., Cho, C.H., Wang, W.P., Kung, H.F. and Lam, S.K. 1L1(beta) Induces cox-2 expression in gastric cancer cells by the p38 and p44/42 MAP kinase
signaling pathways. Journal of Gastroenterology and Hepatology, 16:1098-1104, 2001.
222.
Fan, X.M., Wong, B.C.Y., Zhou X.M., Wang, W.P., Lin, M.C.M., Kung, H.F., Yuen, S.T.,
Leung, S.Y. and Lam, S.K. Inhibition of proteasome function induced apoptosis in gastric
cancer cells. Int J. Cancer, 93(4):481-8, 2001. Impact Factor: 3.545.
224.
Peng, Y., Xu, R.H., Mei, J.M., Li, X.P., Yan, D., Kung, H.F. and Phang, J.M. Neural inhibition
by c-jun as a synergizing factor in BMP-4 signaling. Neuroscience, 109(4):657-664, 2002.
225.
Chen, F., Bower, J., Leonard, S.S., Ding, M., Lu, Y.J., Rojanasakul, Y., Kung, H.F., Vallyathan,
V., Castranova, V. and Shi, X.L. Protective roles of NF-kB for chromium (VI) – induced
cytotoxicity is revealed by expression of IkB kinase-b mutant. J. Biol. Chem., 277:3342-9, 2002.
226
Wong, K., Peng, Y., Kung, H.F. and He, M.L. Retina dorsal/ventral patterning by Xenopus
TBX3. Biochem. & Biophysical Res. Comm., 290:737-742, 2002.
227.
Ching, Y.P., Zhou, H.J., Yuan, J.G., Qiang, B.Q., Kung, H.F. and Jin, D.Y. Identification and
characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal
RNA methyltransferase. Genomics, 79(1):2-6, 2002.
228.
Wong, C.M., Zhou, Y., Ng, R.W., Kung, H.F. and Jin, D.Y. Cooperation of yeast
peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J.
Biol. Chem. 277(7):5385-94, 2002.
229.
Zhou, Y., Ching, Y.P., Kok, K.H., Kung, H.F. and Jin, D.Y. Post-transcriptional suppression of
gene expression in Xenopus embryos by small interfering RNA. Nucl. Acids Res., 30:1664-1669,
2002.
230.
Huang, J.J., Lin, M.C.M., Bai, Y.X., Jing, D.D., Wong, B.C.Y., Han S.W., Lin, J., Xu, B., Huang
C.F. and Kung, H.F. Ectopic expression of a C-terminal fragment of the human telomerase
reverse transcriptase leads to telomere dysfunction and reduction of growth and tumorigenicity in
HeLa cells. Cancer Research, 62:3226-3232, 2002.
231.
Lin, M.C.M., Wang, E.J., Lee, C., Chin, K.T., Liu, D., Chiu, J.F. and Kung, H.F. Garlic inhibits
microsomal triglyceride transfer protein (MTP) gene expression in human liver and intestinal cell
lines and in rat intesine. The Journal of Nutrition, 132:1165-1168, 2002.
232.
Lau, G.K.K., Nanji, A., Hou, J., Fong, D.Y.T., Au, W.S., Yuen, S.T., Lin, M.C.M., Kung, H.F.
and Lam, S.K. Thymosin-1 and famciclovir combination therapy activates T-cell response in
21
Hsiang-fu Kung, Ph.D.
patients with chronic HBV infection in immune tolerant phase. Journal of Viral Hepatitis, 9(4),
280-287, 2002.
233.
Jiang, X.H., Lam, S.K., Lin, M.C.M., Jiang, S.H., Kung, H.F., Slosberg, E.D., Soh, J.W.,
Weinstein, I.B and Wong, B.C.Y. Novel target for induction of apoptosis by cyclooxygenase-2
inhibitor SC-236 through a protein kinase C-B1-dependent pathway. Oncogene, 21:6113-22,
2002.
234.
He, M.L., Wu, J., Chen, Y., Lin, M.C.M., Lau, G.K.K. and Kung, H.F. A new and sensitive
method for the quantification of HBV cccDNA by real-time PCR. BBRC 295:1102-1107, 2002.
235
He, M.L., Chen, Y., Peng, Y., Jing, D.D., Du, D., Wu, J., Lu, P., Lin, M.C.M. and Kung, H.F.
Induction of apoptosis and inhibition of cell growth by developmental regulator hTBX5. BBRC
297:185-192, 2002
236.
Hwang, Y.S., Seo, J.J., Cha, S.W., Lee, H.S., Lee, S.Y., Roh, D.H., Kung, H.F., Kim, J. and Park,
M.J. Antimorphic PV.1 causes secondary axis by inducing ectopic organizer. BBRC 292:10811086, 2002
237.
Chen, Y., Cheung, K.M.C., Kung, H.F., Leong, J.C.Y., Lu, W.W. and Luk, K.D.K. In vivo new
bone formation by direct transfer of adenoviral-mediated bone morphogenetic protein-4 gene.
BBRC 298:121-127, 2002
238.
Wong, C.M., Ching, Y.P., Zhou, Y., Kung, H.F. and Jin, D.Y. Transcriptional regulation of
yeast peroxiredoxin gene TSA2 through Hap1p, Rox1p and Hap2/3/5p. Free Rad. Biol. Med.
2003 Mar 1; 34(5):585-97
239.
Chie, L., Friedman, F.K., Kung, H.F., Lin, M.C., Chung, D. and Pincus M.R. Identification of
the site of inhibition of mitogenic signaling by oncogenic ras-p21 by ras effector peptide.
Journal of Protein Chemistry, 2002 Jul;21(5):367-70.
240.
Chen, Y., Luk, K.D.K., Cheung, K.M.C., Xu, R., Lin, M.C.M., Leong, J.C.Y., Lu W.W. and
Kung, H.F. Gene therapy for new bone formation using adeno-associated viral bone
morphogenetic protein-2 vectors. Gene Therapy, 2003 Aug;10(16):1345-53
241.
Wong, B.C.Y., Jiang, X.H., Fan, X.M., Lin, M.C.M., Jiang, S.H., Lam, S.K. and Kung, H.F.
Suppression of RelA/p65 nuclear translocation independent of IB- degradation by
cyclooxygenase-2 inhibitor in gastric cancer. Oncogene 2003; 22(8): 1189-97
242.
Wu, J., Xia, H.H.X., Tu, S.P., Fan, D.M., Lin, M.C.M., Kung, H.F., Lam, S.K. and Wong, B.C.Y.
15-lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Carcinogenesis, 24(2):243-7, Feb. 2003
243.
Xu, R., Li H., Tse L.Y., Kung, H.F., Lu, H. and Lam K.S.L. Diabetes Gene Therapy: Potential
and Challeges. Current Gene Therapy 3:65-82, 2003
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Hsiang-fu Kung, Ph.D.
244.
Huang, J.J., Han, S.W., Bai, Y.X., Ng, S.S.M., Jing, D.D., Wong, B.C.Y., Huang, C.F., Kung,
H.F. and Lin M.C.M. A human TERT C-terminal polypeptide sensitizes HeLa cells to H2O2 induced senescence without affecting telomerase enzymatic activity. BBRC 301:627-632, 2003
245.
Xu, R., Sun, X., Tse, L.Y., Li, H., Chan, P.C., Xu, S., Xiao, W., Kung, H.F., Krissansen, G.W.
and Fan, S.T. Long-term expression of angiostatin suppresses metastatic liver cancer in mice.
Hepatology. 2003 Jun;37(6):1451-60.
246.
He, Q.Y., Lau, G.K.K., Yuen, S.T., Zhou, Y., Kung, H.F., Lin, M.C.M. and Chiu, J.F. Serum
Biomarkers of hepatitis B virus infected liver inflammation: a Proteomic study. Proteomics,
3:666-674, 2003
247.
Deng, Y., Yao, L., Chau, L., Ng, S.S.M., Peng, Y., Liu, X., Au, W.S., Wang, J., Li, F., Ji, S.,
Han, H., Nie, X., Li, Q., Kung, H.F., Leung, S.Y., and Lin, M.C.M. N-MYC downstreamregulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. International Journal of
Cancer, 106:342-347, 2003
248.
Ching, Y.P., Leong, Y.L., Wong, C.M. and Kung, H.F. Identification of an autoinhibitory
domain of p21-activated protein kinase 5. J. Biol. Chem. 278(36):33621-33624, 2003
249.
Au, W.S., Kung, H.F. and Lin, M.C. Regulation of microsomal triglyceride transfer protein gene
by insulin in HepG2 cells, Roles of MAPKerk and MAPKp38. Diabetes, 52:1073-1080, May 2003
250.
Luk, K.D.K., Chen, Y., Cheung, K.M.C., Kung, H.F., Lu, W.W. and Leong, J.C.Y. Adenoassociated virus-mediated bone morphogenetic protein-4 gene therapy for in vivo bone formation.
BBRC, 308:636-645, 2003
251.
He, M.L., Zheng, B.J., Peng, Y., Peiris, J.S.M., Poon, L.L.M., Yuen, K.Y., Lin, M.C.M., Kung,
H.F. and Guan, Y. Inhibition of SARS-Associated Coronavirus infection and replication by
RNA interference. JAMA, 290:2665-2666, 2003
252.
Chen, Y., Du, D., Wu, J., Chan, C.P., Tan, Y.Q., Kung, H.F. and He, M.L. Inhibition of hepatitis
B virus (HBV) replication by stably-expressed shRNA. BBRC, 311:398-404, 2003
253.
Tu, S.P., Jiang, X.H., Lin, M.C.M., Cui, J.T., Yang, Y., Lum, C.T., Zou, B., Zhu, Y.B., Jiang,
S.H., Wong, W.M., Chan, A.O.O., Yuen, M.F., Lam, S.K., Kung, H.F. and Wong, B.C.Y.
Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric
cancer. Cancer Research, 63(22):7724-7732, Nov. 2003
254.
*Tanner, J.A., *Watt, R.M., Chai, Y.B., Lu, L.Y., Lin, M.C., Peiris, J.S., Poon, L.L., Kung, H.F.,
and Huang, J.D. The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase
belongs to a distinct class of 5’ to 3’ viral helicases. J. Biol. Chem. 278(41):39578-82, 2003
255.
Peng, Y., Yang, P.H., Guo, Y., Ng, S.S.M., Liu, J., Fung, P.C.W., Tay, D., Ge, J., He, M.L.,
Kung, H.F. and Lin, M.C.M. Catalase and peroxiredoxin 5 protect xenopus embryos against
23
Hsiang-fu Kung, Ph.D.
alcohol-induced ocular anomalies. Investigative Ophthalmology & Visual Science, 45(1):23-29,
Jan. 2004
256.
Wong, B.C.Y., Jiang, X.H., Lin, M.C.M., Tu, S.P., Cui, J.T., Jiang, S.H., Wong, W.M., Yuen,
M.F., Lam, S.K. and Kung, H.F. Cyclooxygenase-2 inhibitor (SC-236) suppresses activator
protein-1 through c-Jun NH2-terminal kinase. Gastroenterology, 126:136-147, 2004
259. Peng, Y., Yang, P.H., Wong, O.G.W., Ng, S.S.M., Liu, J., He, M.L., Kung, H.F. and Lin, M.C.M.
A critical role of Pax6 in alcohol-induced fetal microcephaly. Neurobiology of Disease, 16:370376, 2004
260.
Li, X.P., Li, G., Peng, Y., Kung, H.F. and Lin, M.C.M. Suppression of Epstein-Barr virusencoded latent membrane protein-1 by RNA interference inhibits the metastatic potential of
nasopharyngeal carcinoma cells. BBRC, 315:212-218, 2004
261.
Qi, R.Z., Ching, Y.P., Kung, H.F. and Wang, J.H. α-Chimaerin exists in a functional complex
with the neuronal Cdk5 kinase in brain. FEBS Lett, 12:561(1-3):177-180, 2004
262
He, Q.Y., Chen, J., Kung, H.F., Yuen, A.P.W. and Chiu, J.F. Identification of tumor-associated
proteins in oral tongue squamous cell carcinoma by proteomics. Proteomics, 4:271-278, 2004
263
Chen, Y., Luk, K.D.K., Cheung, K.M.C., Lu, W.W., An, X.M., Ng, S.S.M., Lin, M.C.M. and
Kung, H.F. Combination of adeno-associated virus and adenovirus vectors expressing bone
morphogenetic protein-2 produces enhanced osteogenic activity in immunocompetent rats.
BBRC, 317:675-681, 2004
264
Fan, X.M., Tu, S.P., Lam, S.K., Wang, W.P., Wu, J., Wong, W.M., Yuen, M.F., Lin, M.C.M.,
Kung, H.F. and Wong, B.C.Y. Five-lipoxygenase-activating protein inhibitor MK-886 induces
apoptosis in gastric cancer through upregulation of p27kip1 and bax.
Journal of
Gastroenterology and Hepatology, 19(1):31-37, Jan. 2004
265
Peng, Y., Jiang, B.H., Yang, P.H., Cao, Z., Shi, X., Lin, M.C., He, M.L. and Kung, H.F.
Phosphatidylinositol-3 kinase signaling is involved in neurogenesis during Xenopus embryonic
development. J. Biol. Chem., 279(27):28509-14, Apr. 29, 2004
266
Peng, Y., Yang, P.H., Ng, S.S.M., Lum, M., *Kung, H.F. and *Lin, M.C. Protection of Xenopus
laevis embryos against alcohol-induced delayed gut maturation and growth retardation by
peroxiredoxin 5 and catalase. J. Mol. Biol., 340:819-827, 2004
267
Chen, Y., Kong, L.D., Xia, X., Kung, H.F. and Zhang, L. Behavioral and biochemical studies of
total furocoumarins from seeds of Psorales corylifolia in the forced swimming test in mice.
Journal of Ethnopharmacology, 2005 Jan 15;96(3):451-9. Epub 2004 Nov 19.
268
Zheng, B., He, M.L., Wong, K.L., Lum, C.T., Poon, L.L.M., Peng, Y., Guan, Y., Lin, M.C.M.
and Kung, H.F. Potent inhibition of SARS-associated coronavirus (SCoV) infection and
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Hsiang-fu Kung, Ph.D.
replication by type I interferons (IFN α/β) but not by type II interferon (IFNγ). Journal of
Interferon & Cytokine Research, 2004 Jul;24(7):388-90
269
Jiang, X.H., Tu, S.P., Cui, J.T., Lin, M.C.M., Xia, H.H.X., Wong, W.M., Chan, A.O.O., Yuen,
M.F., Jiang, S.H., Lam, S.K., Kung, H.F., Soh, J.W., Weinstein I.B. and Wong B.C.Y. Antisense
targeting protein kinase Ca and b1 inhibits gastric carcinogenesis. Cancer Research, 2004 Aug
15;64(16):5787-94.
270
Yiu, S.M., Wong, P.W.H., Lam, T.W., Mui, Y.C., Kung, H.F., Lin, M.C. and Cheung, Y.T.
Filtering of ineffective siRNAs and improved siRNA design tool. Bioinformatics, 21:144-151,
2005
271
Xia, H.H.X., Zhang, S.T., Lam, S.K., Lin, M.C.M., Kung, H.F. and Wong, B.C.Y. Expression of
macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of
bile acids and NSAIDs. Carcinogenesis, 26(1):11-5, 2005 Jan
272
Tu, S.P., Cui, J.T., Liston, P., Jiang, X.H., Xu, R., Lin, M.C.M., Zhu, Y.B., Zou, B., Ng, S.S.M.,
Jiang, S.H., Xia, H.H.X., Wong, W.M., Chan, A.O.O., Yuen, M.F., Lam, S.K., Kung, H.F. and
Wong, B.C.Y. Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer
of survivin Cys84Ala mutant. Gastroenterology, 128:361-375, 2005
273
Peng, Y., Kwok, K.H.H., Yang, P.H., Liu, J., Wong, O.G., He, M.L., Kung, H.F. and Lin,
M.C.M. Ascorbic acid inhibits ROS production, NF-kB activation and prevents ethanol-induced
growth retardation and microencephaly. Neuropharmacology, 48:426-434, 2005.
274
Gu, Q., Wang, J.D., Xia, H.H.X., Lin, M.C., He, H., Zou, B., Tu, S.P., Yang, Y., Liu, X.G., Lam,
S.K., Wong, W.M., Chan, A.O.O., Yuen, M.F., Kung, H.F., and Wong, B.C.Y. Activation of
caspase-8/Bid and bax pathways in aspirin-induced apoptosis in gastric cancer. Carcinogenesis,
26:541-6, 2005 Mar
275
Queenie Wong, Marie Lin, Hsiang-fu Kung, Vivian Ng, Danny Chan and Jian-Dong Huang
Efficient and Seamless DNA Recombineering using a Thymidylate Synthase A Selection System
in Escherichia coli. Nucleic Acids Research, 2005 Mar 30;33(6):e59.
276
Julian A. Tanner, Bo-Jian Zheng, Jie Zhou, Rory M. Watt, Jie-Qing Jiang, Kin-Ling Wong,
Yong-Ping Lin, Lin-Yu Lu, Ming-Liang He, Hsiang-Fu Kung, Andreas J. Kesel, and Jian-Dong
Huang The Adamantane-Derived Bananins Are Potent Inhibitors of the Helicase Activities and
Replication of SARS Coronavirus. Chemistry & Biology 2005 Mar;12(3):303-11.
277
Xia HH, Lam SK, Chan AO, Lin MC, Kung HF, Ogura K, Berg DE, Wong BC Macrophage
migration inhibitory factor stimulated by Helicobactor pylori increases proliferation of gastric
epithelial cells. World J Gastroenterol. 2005 April 7; 11(13): 1946-50
278
Harry Hua-Xiang Xia, Shiu Kum Lam, Annie O.O.Chan, Marie Chia Mi Lin, Hsiang Fu Kung,
Keiji Ogura, Douglas E. Berg, and Benjamin Chun-Yu Wong Macrophage migration inhibitory
25
Hsiang-fu Kung, Ph.D.
factor stimulated by Helicobacter pylori increases proliferation of gastric epithelial cells. World
Journal of Gastroenterology, 2005; 11(13): 1946-1950
279
Wei-Ping Qian, Yue-Qie Tan, Ying Chen, Ying Peng, Zhi Li, Guang-Xie Lu, Marie C. Lin,
Hsiang-Fu Kung, and Ming-Ling He Rapid quantification of semen hepatitis B virus DNA by
real-time polymerase chain reaction. World Journal of Gastroenterology, 2005 Sep 14;
11(34):5385-9.
280
Chuan-Yuan Li, Qian Huang and Hsiang-Fu Kung Cytokine and Immuno-Gene Therapy for
Solid Tumors Cellular & Molecular Immunology, 2005 Apr;2(2):81-91.
281
Bo-Jian Zheng, Yi Guan, Ming-Liang He, Hongzhe Sun, Lanying Du, Ying Zheng, Kin-Ling
Wong, Honglin Chen, Ying Chen, Linyu Lu, Julian A Tanner, Rory M Watt, Neri Niccolai,
Andrea Bernini, Ottavia Spiga, Patrick CY Woo, Hsiang-fu Kung, Kwok-Yung Yuen and JianDong Huang Synthetic peptides outside the spike protein heptad repeat regions as potent
inhibitors of SARS-associated coronavirus Antiviral Therapy, 2005; 10(3): 375-385
282
Ze-Hao Zhuang, Sai-Wah Tsao, Wen Deng, Ji-De Wang, Harry Hua-Xiang Xia, Hua He, HuiChen Feng, Li-dong Wang, Sen-Lin Zhu, Li-Fen Yu, Yun-Wei Sun, Marie C.M.Lin, Hsiang-Fu
Kung, and Benjamin C.Y.Wong Early induction of cyclooxygenase-2 in human papillomavirus
type 16- and telomerase-induced immortalization of human esophageal epithelial cells J
Gastroenterol Hepatol. 2008 Oct;23(10):1613-20. Epub 2008 Aug 20
283
Hong Ma, Yanxin Liu, Shilian Liu, Hsiang-Fu Kung, Xueying Sun, Dexian Zheng and Ruian Xu
Recombinant adeno-associated virus-mediated TRAIL gene therapy suppresses liver metastatic
tumors Int. J. Cancer, 2005; 116, 314-321
284
Victor Adler, Yongxia Qu, Steven J. Smith, Lara Izotova, Sidney Pestka, Hsiang-fu Kung, Marie
Lin, Fred K. Friedman, Lyndon Chie, Denise Chung, Mohamed Boutjdir and Matthew R. Pincus
Functional Interactions of raf and MEK with jun-N-Terminal Kinase (JNK) Result in a Positive
Feedback Loop on the Oncogenic ras Signaling Pathway
Biochemistry, 2005 Aug
16;44(32):10784-95
285
Wei-Ping Qian, Yue-Qiu Tan, Ying Chen, Ying Peng, Zhi Li, Guang-Xiu Lu, Marie C. Lin,
Hsiang-fu Kung, Ming-Ling He Rapid quantification of semen hepatitis B virus DNA by realtime polymerase chain reaction World Journal of Gastroenterology 2005; 11(34): 5385-5389
286
Wang J, He H, Yu L, Xia HH, Lin MC, Gu Q, Li M, Zhou B, An X, Jiang B Kung HF, Wong
BC Heat shock factor 1 (HSF1) downregulates X-linked inhibitor of apoptosis proteinassociated factor 1 (XAF1) through transcriptional regulation. J Biol Chem 2006 Feb 3; 281 (5):
2451-9
287
Jide Wang, Ying Peng, Yun Wei Sun, Bing Zhou, Senlin Zhu, Xiaomeng An, Ming Li, Marie
C.M. Lin, Harry Hua-Xiang Xia, Annie O.O. Chan, Bo Jiang, Man Fung Yuen, Hsiang Fu Kung,
Benjamin C.Y. Wong. All-trans retinoic acid induces XAF1 expression through an interferon
regulatory factor-1 element in colon cancer. Gastroenterology, 2006 Mar;130(3):747-58
26
Hsiang-fu Kung, Ph.D.
288
Li XP, Li CY, Li X, Ding Y, Chan LL, Yang PH, Li G, Liu X, Lin JS, Wang J, He M, Kung HF,
Lin MC, Peng Y Inhibition of Human Nasopharyngeal Carcinoma Growth and Metastasis in
Mice by Adenovirus-associated Virus Mediated Expression of Human Endostatin, Molecular
Cancer Therapeutics, 2006 May;5(5):1290-8
289
Ming Li, Samuel Sai-ming Ng, Jide Wang, Lihui Lai, Suet Yi Heung, Michel Franco, Ying Peng,
Ming-liang He, Hsiang-fu Kung and Marie Chia-mi Lin EFA6A enhances glioma cell invasion
through ADP ribosylation factor 6/extracellular signal-regulated kinase signaling Cancer
Research 2006 Feb 1;66(3):1583-90.
290
Lin MC, Lee NP, Zheng N, Yang PH, Wong OG, Kung HF, Hui CK, Luk JM, Lau GK. Tumor
necrosis factor-alpha-induced protein 1 and immunity to hepatitis B virus. World J Gastroenterol.
2005 Dec 28; 11(48):7564-8.
291
Hua He, Harry Hua-Xiang Xia, Ji DeWang, Qing Gu, Marie C.M. Lin, Bing Zhou, Shiu Kum
Lam, Annie O.O. Chan, Man Fung Yuen, Hsiang Fu Kung, Benjiamin Chun-Yu Wong
Inhibition of Human Telomerase Reverse Transcriptase by Nonsteroidal Antiinflammatory
Drugs in Colon Carcinoma Cancer, 2006 Mar 15;106(6):1243-9
292
Wang X, Li M, Wang J, Yeung CM, Zhang H, Kung HF, Jiang B, Chia-mi Lin M The BH3-only
protein, PUMA, is involved in oxaliplatin—induced apoptosis in colon cancer cells.
Biochemical Pharmacology 2006 May 28;71(11):1540-50. Epub 2006 Apr 3.
293
Fan XM, Jiang XH, Gu Q, Ching YP, He H, Xia HHX, Lin MCM, Chan AOO, Yuen MF, Kung
HF, Wong BCY Inhibition of Akt/PKB by a COX-2 inhibitor induces apoptosis in gastric cancer
Digestion, 2006;73(2-3):75-83. Epub 2006 Apr 19.
294
Peng Y, Yang PH, Tanner JA, Huang JD, Li M, Lee HF, Xu RH, Kung HF, Lin MC ColdInducible RNA Binding Protein is Required for the Expression of Adhesion Molecules and
Embryonic Cell Movement in Xenopus Laevis Biochemical and Biophysical Research
Communications, 2006 May 26;344(1):416-24. Epub 2006 Mar 24.
295
Q. Gu, H.H.X. Xia, J.D. Wang, A.O.O. Chan, K.C. Lai, C.K. Chan, M.F. Yuen, F.M.Y. Fung,
K.W. Wong, H.K.L. Cheung, H.F. Kung, B.C.Y. Wong Update on clarithromycin resistance in
Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy.
Digestion 2006;73(2-3):101-6. Epub 2006 Jun 20.
296
Longfei Huo, Janice WS Tang, JunJian Huang, Peitang Huang, Cuifen Huang, Hsiang-fu Kung
and Marie C. Lin Cancer Immunotherapy Targeting the Telomerase Reverse Transcriptase
Cellular & Molecular Immunology 2006 Feb;3(1):1-11.
297
Chun-Feng Qiao, Quan-Bin Han, Shi-fu Mo, Jing-Zheng Song, Li-Jia Xu, Shi-Lin Chen, Da-Jian
Yang, Ling-Dong Kong, Hsiang-fu Kung, Hong-Xi Xu Psoralenoside and isoposoralenoside,
two new bezofuran glycosides from Psoralea corylifolia Chemical & Pharmaceutical Bulliten,
54(5), 714-716, 2006
27
Hsiang-fu Kung, Ph.D.
298
Shi YF, Zhang Q, Cheung PY, Shi L, Fong CC, Zhang Y, Tzang CH, Chan BP, Fong WF, Chun
J, Kung HF, Yang M Effects of rhDecorin on TGF-β1 induced human hepatic stellate cells LX-2
activation. Biochim Biophys Acta. 2006, 1760: 1587-95
299
Cheung PY, Zhang Q, Zhang YO, Bai GR, Lin MC, Chan B, Fong CC, Shi L, Shi YF, Chun J,
Kung HF, Yang M Effect of WeiJia on carbon tetrachloride induced chronic liver injury. World
J Gastroenterol. 2006 28; 12(12): 1912-7
300
He ML, Zheng BJ, Chen Y, Wong KL, Huang JD, Lin MC, Peng Y, Yuen KY, Sung JJ, Kung
HF Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of
SARS-associated coronavirus. FEBS Lett. 2006 May 1; 580(10): 2414-20
301
Chun-Feng Qiao, Quan-Bin Han, Jing-Zheng Song, Shi-fu Mo, Ling-Dong Kong, Hsiang-fu
Kung, Hong-Xi Xu Quality assessment of Fructus Psoraleae, Chemical & Pharmaceutical
Bulliten, 54(6): 887-890, 2006
302
Yong Liang, Marong Fang, Jicheng Li, Chi Bo Liu, John A. Rudd, H.F. Kung. David T.W. Yew
Serum Proteomic Patterns for Gastric Lesions as revealed by SELDI mass spectrometry
Experimental and Molecular Pathology, 81(2006): 176-180
303
Kenneth Tong, He Ming-Liang, Kung Hsiang-fu, Joseph Sung, Lee Shui Shan The implications
of a high allelic frequency of CYP2B6 G516T in ethnic Chinese persons Clinical Infectious
Diseases, 15 August, 2006; 43:541-542
304
Ching Tung Lum, Zhen Fan Yang, Hoi Yee Li, Raymond Wai-Yin Sun, Sheung Tat Fan, Ronnie
Tung Ping Poon, Marie C.M. Lin, Chi-Ming Che and Hsiang-fu Kung Gold (III) compound is a
novel chemocytotoxic agent for hepatocellular carcinoma Int. J. Cancer: 118:1527-1538, 2006
305
XP Li, Peng Ying, Hu Xiong, David Chau, H.F. Kung and M.C. Lin Recombination adenoassociated virus (rAAV) mediated RNA interference inhibits metastasis of nasopharyngeal
cancer cells in vivo and in vitro by suppression of Epstein-Barr virus encoded LMP-1
International Journal of Oncology, 2006 Sep;29(3):595-603.
306
Xia HHX, He H, Wang JD, Gu Q, Lin MCM, Zou B, Yu LF, Sun YW, Chan AOO, Kung HF,
Wong BCY Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase
(JNK) inhibitor, SP-600125, in gastrointestinal cancers.
Cancer Letters 2006 Sep
28;241(2):268-74. Epub 2005 Dec 7.
307
Ming-Liang He, Che-Kit Lin, Kenneth Tong, Bingying Xu, Joseph JY Sung, Hsiang-fu Kung,
Shui Shan Lee Absence of CYP2B6 promoter-82T>C mutation in Chinese as an additional
factor for slow metabolism of drugs commonly used in infections. European Journal of Clinical
Pharmacology Vol.62, 585-586
28
Hsiang-fu Kung, Ph.D.
308
Ching-Chiu Liu, Zan Shen, Hsiang-fu Kung, Marie CM Lin Cancer gene therapy targeting
angiogenesis: An updated review World J Gastroenterol, 2006 Nov 21;12(43):6941-8.
309
Zou B, Chim CS, Zeng H, Leung SY, Yang Y, Tu SP, Lin MCM, Wang J, He H, Jiang SH, Sun
YW, Yu LF, Yuen ST, Kung HF, Wong BCY Correlation between the Single-Site CpG and
Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers Gastroenterology
2006; 131:1835-1843
310
Watt RM, Wang J, Leong M, Kung HF, Cheah KS, Liu D, Danchin A, Huang JD Visualizing
the proteome of Escherichia coli: an efficient and versatile method for labeling chromosomal
coding DNA sequences (CDSs) with fluorescent protein genes. Nucleic Acids Res. 2007;
35(6):e37.
311
Yangchao Chen, Marie C. Lin, Hong Yao, Hua Wang, Ai-Qun Zhang, Jun Yu, Chee-kin Hui,
George K. Lau, Ming-liang He, Joseph Sung, and Hsiang-fu Kung Lentivirus-mediated RNA
interference targeting EZH2 inhibits hepatocellular carcinoma growth via down-regulation of
stathmin. Hepatology, 2007; 46:200-208
312
Li Fen Yu, Jide Wang, Bing Zou, Marie CM Lin, Yun Lin Wu, Harry HX Xia, Yun Wei Sun,
Qing Gu, Hua He, S.K. Lam, Hsiang Fu Kung, Benjamin C.Y. Wong
XAF1 Mediates
Apoptosis Through Extracellular Signal Regulated Kinase Pathway in Colon Cancer Cancer.
2007 May 15;109(10):1996-2003
313
Wang J, Yang Y, Xia HH, Gu Q, Lin MC, Jiang B, Peng Y, Li G, An X, Zhang Y, Zhuang Z,
Zhang Z, Kung HF, Wong BC Suppression of FHL2 Expression Induces Cell Differentiation
and Inhibits Gastric and Colon Carcinogenesis. Gastroenterology. 2007 Mar; 132(3): 10661076.
314
Ng SS, Gao Y, Chau DH, Li GH, Lai LH, Huang PT, Huang CF, Huang JJ, Chen YC, Kung HF,
Lin MC A novel glioblastoma cancer gene therapy using AAV-mediated long-term expression
of human TERT C-terminal polypeptide Cancer Gene Ther, 2007 Jun; 14(6):561-72.
315
Samuel SM Ng, Yuen-Ting Cheung, Ming Li, Xiao-Meng An, Gloria Hoi-Yee Li, William
Cheung, Johnny Sze, Lihui Lai, Ying Peng, Harry H. X. Xia, Benjamin CY Wong, Suet-Yi
Leung, Dan Xie, Dan Xie, Ming-Liang He, Hsiang-fu Kung and Marie C. Lin Cell cycle related
kinase (CCRK) is a novel candidate oncogene in human glioblastoma JNCI, 2007; 99:936-48
316
Ng SS, Cheung YT, An XM, Chen YC, Li M, Li GH, Cheung W, Sze J, Lai L, Peng Y, Xia HH,
Wong BC, Leung SY, Xie D, He ML, Kung HF, Lin MC Cell cycle-related kinase is involved in
human glioblastoma carcinogenesis. Nat Clin Pract Oncol 2007; 4:558
317
Yangchao Chen, Marie Chia-mi Lin, Hua Wang, Chu-yan Chan, Lei Jiang, Sai Ming Ngai, Jun
Yu, Ming-liang He, Pang-chui Shaw, David T. Yew, Joseph J. Sung and Hsiang-fu Kung
Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma Proteomics,
2007 Sep;7(17):3097-104
29
Hsiang-fu Kung, Ph.D.
318
SS Lee, B Zhang, ML He, VSC Chang and HF Kung Screening of Active Ingredients of Herbal
Medicine for Interaction with CYP450 3A4 Phytotherapy Research, 2007 Nov;21(11):1096-9.
319
Jie Liu, Guo Z. Yang, Jin L. Zhou, Shi P. Cao, David H. W. Chau, Hsiang-fu Kung and
Marie C. Lin Prevalence of neural tube defects in economically and socially deprived area of
China Child's Nervous System (2007) 23: 1119-1124
320
Ying Pan, Ling-Dong Kong, Ye-Cheng Li, Xing Xia, Hsiang-fu Kung, Fu-Xing Jiang Icariin
from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and
neuroendocrinological alterations in male Wistar rats Pharmacology Biochemistry and Behavior,
2007 May; 87(1):130-40.
321
Y. Chen., H.-D. Wang, X. Xia, H.-F. Kung, Y. Pan, L.-D. Kong Behavioral and biochemical
studies of total furocoumarins from seeds of Psoralea corylifolia in the chronic mild stress model
of depression in mice. Phytomedicine, 2007, 2007 Aug; 14(7-8):523-9.
322
Nan Yang, Julian A. Tanner, Bo-Jian Zheng, Rory M. Watt, Ming-Liang He, Lin-Yu Lu, JieQing Jiang, Ka-To Shum, Yong-Ping Lin, Kin-Ling Wong, Marie C.M. Lin, Hsiang-fu Kung,
HongZhe Sun, and Jian-Dong Huang Bismuth Complexes Inhibits the SARS Coronavirus,
Angew Chem Int Ed Engl. 2007 Jul 23;46 (34): 6464-6468
323
Dan Xie, Ning-Fang Ma, Zhi-Zhong Pan, Hui-Xi Wu, Yong-Dong Liu, Guo-Qing Wu, Hsiangfu Kung, Xin-Yuan Guan Overexpression of EIF-5A2 is associated with metastasis of human
colorectal carcinoma Human Pathology, 2008 Jan; 39(1):80-6
324
Wai MS, Lorke DE, Zhang A, Kung HF, Yew DT Study of the spinal cords of the sturgeon
Acipenser schrenckii, gar Lepisosteus oculatus, and goldfish Carassius auratus by morphological,
immunohistochemical, and biochemical approaches Microsc Res Tech. 2007 Dec; 70(12):107990
325
Xu J, Zou Y, Zhang LH, Wai MS, Kung HF, Ge ZY, Yew DT Postmortem MRI changes of the
brains of the rats of different ages, Int J Neurosci. 2008 Jul; 118(7):1039-50
326
Lin Du, JianZhao Chen, Yanting Qi, Dan Li, Chonggang Yuan, Marie C Lin, David T Yew,
Hsiang-fu Kung, Jimmy C Yu and Lihui Lai Preparation and biomedical application of a
nonpolymer coated superparamagnetic nanoparticle, International Journal of Nanomedicine
2007; 2(4):805-812
327
Samuel S. Ng, Pai-Hao Yang, Yuanyuan Cheng, Ying Peng, Hsiang-fu Kung and Marie C. Lin
Differential and critical roles of reactive oxygen species and reactive nitrogen species in alcoholinduced gene dysregulations and birth defects in Xenopus embryos Neuroembryology and
ageing, 2006-07; 4:155-161
328
Zan Shen, Zhen Fan Yang, Yi Gao, Cheng Li, Hai Xiao Chen, Ching Chiu Liu, Ronnie T.P.
Poon, Sheung Tat Fan, John M. Luk, Kong Hung Sze, Tsai Ping Li, Ren Bao Gan, Ming Liang
He, Hsiang-fu Kung and Marie CM Lin The Kringle 1 domain of hepatocyte growth factor has
30
Hsiang-fu Kung, Ph.D.
antiangiogenic and antitumor cell effects on hepatocellular carcinoma Cancer Res 2008 Jan 15;
68(2):404-14
329
Yang PH, K C Cheung W, Peng Y, He ML, Wu GQ, Xie D, Jiang BH, Huang QH, Chen Z, C M
Lin M, Kung HF. Makorin-2 is a neurogenesis inhibitor downstream of PI3K/AKT signal J Biol
Chem, 2008 Mar 28; 283(13):8486-95
330
Zhi Li, Hong Yao, Yan Ma, Qingming Dong, Yangchao Chen, Ying Peng, Bo-jian Zheng, Jiandong Huang, Chu-yan Chan, Marie C. Lin, Joseph J Sung, Kwok Yun, Yuen, Hsiang-fu Kung,
Ming-Liang He Inhibition of HBV gene expression and replication by stably expressed
interferon-1 via adeno-associated viral vectors J Gene Med. 2008 Jun; 10(6):619-27.
331
Yunwei Sun, Liang Qiao, Harry Hua-Xiang Xia, Marie C.M. Lin, Bing Zou, Yaozong Yuan,
Senlin Zhu, Qing Gu, Ting Kin Cheung, Hsiang-fu Kung, Man Fung Yuen, Annie OO Chan,
Benjamin C.Y. Wong Regulation of XAF1 expression in human colon cancer cell by interferon
B: Activation by the transcription regulator STAT1 Cancer Letters 2008 Feb 18; 260(1-2):62-71
332
Yanting Qi, Xiaona Chen, Chu-yan Chan, Dan Li, Chonggang Yuan, Fei Yu, Marie C. Lin,
David T. Yew, Hsiang-fu Kung and Lihui Lai Two-dimensional differential gel
electrophoresis/analysis of diethylnitrosamine induced rat hepatocellular carcinoma Int J Cancer.
2008 Jun 15; 122(12):2682-8
333
Li-tao Yi, Yu-cheng Li, Ying Pan, Jian-mei Li, Qun Xu, Shi-fu Mo, Chun-feng Qiao, Fu-xin
Jiang, Hong-xi Xu, Xiaobo-Lu, Ling-dong Kong, Hsiang-fu Kung Antidepressant-like effects of
psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2008; 32:510-519
334
Meng-Zhong Liu, Dan Xie, Shi-Juan Mai, Zhu-Ting Tong, Jian-Yong Shao, Yong-Shui Fu,
Wen-Jie Xia, Hsiang-fu Kung, Xin-Yuan Guan and Yi-Xin Zeng Overexpression of AIB1 in
Nasopharyngeal Carcinomas Correlates Closely with Advanced Tumor Stage Am J Clin Pathol.
2008 May; 129(5):728-34
335
Chen Y, Cheung YT, Kong LD, Ng TB, Qiao CF, Mo SF, Xu HX, Kung HF.
Transcriptional
regulation
of
corticotrophin
releasing
factor
gene
by
furocoumarins isolated from seeds of Psorales corylifolia. Life Sci. 2008 May 23; 82(2122):1117-21.
336
Zhuang ZH, Tsao SW, Deng W, Wang JD, Xia HH, He H, Feng HC, Wang LD, Gu Q, Lam SK,
Lin MC, Kung HF, Wong BC. Early upregulation of cycloosygenase-2 in human papilomavirus
type 16 and telomerase induced immortalization of human esophageal epithelial cells Journal of
Gastroenterology and Hepatology, 2008 Oct;23(10):1613-20. Epub 2008 Aug 20.
337
Nie B, Shen Z, Wen JB, Wong OG, Hsueh WD, Huo LF, Kung HF, Jiang B, Lin MC AAVHGFK1 and Ad-p53 cocktail therapy prolongs survival of mice with colon cancer Mol Cancer
Ther. 2008 Sep; 7(9):2855-65.
31
Hsiang-fu Kung, Ph.D.
338
Xin Wang, Yangchao Chen, Quan-bin Han, Chu-yan Chan, Hua Wang, Zheng Liu, Christopher
Hon-ki Cheng, David T. Yew, Marie CM Lin, Ming-liang He, Hong-xi Xu, Joseph JY Sung,
Hsiang-fu Kung Proteomic Identification of Molecular Targets of Gambogic Acid: Role of
Stathmin in Hepatocellular Carcinoma, PROTEOMICS, 2009 Jan; 9(2):242-53
339
Jie Xu, W.H. Kwong, Maria Sen Mun Wai, E. Lucy Forster, Yan-ling Jiang, Hsiang-fu Kung and
David T. Yew Imaging of the Development Central Nervous System in the Fetus
Neuroembryology and Aging, 2008; 5:32-38
340
Zhi Li, Ming-liang He, Hong Yao, Qingming Dong, Yangchao Chen, Chu-yan Chan, Bo-jian
Zheng, Kwok Yung Yuen, Ying Peng, Qiang Sun, Xiao Yang, Marie C Lin, Joseph. JY Sung and
Hisang-fu Kung Inhibition of HBV replication and gene expression in vitro and in vivo with a
single AAV vector delivering two shRNA molecules BMB Rep. 2009 Jan 31; 42(1):59-64.
341
Qingming Dong, Bingying Xu, Yi Tan, Zheng Liu, Linwei Tian, Bao Zhang, Che-kit Lin,
Hsiang-fu Kung, Joseph JY Sung, Ming Liang He The genetic variability of MDR1 C3435T
polymorphisms in four Southern Chinese populations.
Biomed Pharmacother. 2009
Nov;63(9):658-62. Epub 2008 Sep 25.
342
Li M, Wang J, Ng SS, Chan CY, Chen AC, Xia HP, Yew DT, Wong BC, Chen Z, Kung HF, Lin
MC. The four-and-a-half-LIM protein 2 (FHL2) is overexpressed in gliomas and associated with
oncogenic activities Glia. 2008 Sep;56(12):1328-38.
343
Tan Y, Wei QH, Chen LJ, Chan PC, Lai WS, He ML, Kung HF, Lee SS. Molecular
epidemiology of HCV monoinfection and HIV/HCV coinfection in injection drug users in Liu
Zhou, Southern China. 2008;3(10):e3608. Epub 2008 Oct 31.
344
Wai MS, Liang Y, Shi C, Cho EY, Kung HF, Yew DT. Co-localization of hyperphosphorylated
tau and caspases in the brainstem of Alzheimer's disease patients. Biogerontology. 2009 10:457469
345
Dong Q, Chan HL, Liu Z, Chan DP, Zhang B, Chen Y, Kung HF, Sung JJ, He ML
A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of
hepatocellular carcinoma, reduce basal core promoter activities. Biochem Biophys Res Commun.
2008 Oct 3; 374(4):773-6.
346
Au WS, Lu L, Yeung CM, Liu CC, Wong OG, Lai L, Kung HF, Lin MC Hepatocyte nuclear
factor 1 binding element within the promoter of microsomal triglyceride transfer protein (MTTP)
gene is crucial for MTTP basal expression and insulin responsiveness. J Mol Endocrinol. 2008
Oct; 41(4):229-38.
347
Shen Z, Wong OG, Yao RY, Liang J, Kung HF, Lin MC A novel and effective hepatocyte
growth factor kringle 1 domain and p53 cocktail viral gene therapy for the treatment of
hepatocellular carcinoma. Cancer Lett. 2008 Dec 18; 272(2):268-76. Epub 2008 Aug 21
32
Hsiang-fu Kung, Ph.D.
348
Wang J, Zhang W, Zhang Y, Chen Y, Zou B, Jiang B, Pang R, Gu Q, Qiao L, Lan H, Kung HF,
Wong BC c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1)
through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer. Carcinogenesis. 2009
Feb; 30(2):222-9.
349
Yang GF, Xie D, Liu JH, Luo JH, Li LJ, Hua WF, Wu HM, Kung HF, Zeng YX, Guan XY
Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression
of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma.
Gynecol Oncol. 2009 Feb; 112(2):314-8.
350
Guo Li, Xiao-ai Zhang, Hua Wang, Chun-ling Meng, Chu-yan Chan, David Tai Wai Yew, Xin
Wang, Kam Sze Tsang, Karen Li, Sau-na Tsai, Sai-ming Ngai, Zhong-chao Han, Marie Chia-mi
Lin, Ming-Liang He and Hsiang-fu Kung Comparative proteomic analysis of mesenchymal stem
cells derived from human bone marrow, umbilical cord, and placenta: Implication in the
migration. Proteomics 2008 Dec 30; 9(1):20-30.
351
Jiang L, Chen Y, Chan CY, Lin L, He ML, Lin M, Yew DT, Sung JJY, Lin JC, Kung HF Downregulation of stathmin is regulated for TGF-b inducible early gene 1 induced growth inhibition of
pancreatic cancer cells. Cancer Lett. 2009 Feb 8; 274(1):101-8. Epub 2008 Oct 18
352
Bin Zhang, YunXiu Bai, HangHang Ma, Feng Feng, Rui Jin, ZhiLong Wang, Jian Lin, ShiPeng
Sun, Pingxun Yang, XiaoXiong Wang, PeiTang Huang, CuiFen Huang, Ying Peng, YangChao
Chen, Hsiang-fu Kung and JunJian Huang Silencing PinX1 compromises telomere-length
maintenance as well as tumorigenicity in telomerase-positive human cancer cells Cancer Res.
2009 Jan 1; 69(1):75-83.
353
Xia H, Qi Y, Ng SS, Chen X, Chen S, Fang M, Li D, Zhao Y, Ge R, Li G, Chen Y, He ML,
Kung HF, Lai L, Lin MC MicroRNA-15b regulates cell cycle progression by targeting cyclins
in glioma cells Biochem Biophys Res Commun. 2009 Mar 6; 380(2):205-10. Epub 2009 Jan 9.
354
Chen W, Luo JH, Hua WF, Zhou FJ, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D
Overexpression of EIF-5A2 Is an Independent Predictor of Outcome in Patients of Urothelial
Carcinoma of the Bladder Treated with Radical Cystectomy Cancer Epidemiol Biomarkers Prev.
2009 Feb; 18(2):400-8. Epub 2009 Jan 20
355
Li Z, He ML, Yao H, Dong QM, Chen YC, Chan CY, Zheng BJ, Yuen KY, Peng Y, Sun Q,
Yang X, Lin MC, Sung JJ, Kung HF Inhibition of HBV replication and gene expression in vitro
and in vivo with a single AAV vector delivering two shRNA molecules BMB Rep. 2009 Jan 31;
42(1):59-64.
356
Xia H, Qi Y, Ng SS, Chen X, Li D, Chen S, Ge R, Jiang S, Li G, Chen Y, He ML, Kung HF, Lai
L, Lin MC. microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs
Brain Res. 2009 May 7; 1269:158-65.
33
Hsiang-fu Kung, Ph.D.
357
Luo JH, Hua WF, Rao HL, Liao YJ, Kung HF, Zeng YX, Guan XY, Chen W, Xie D.
Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial
carcinoma of the bladder. Cancer Sci. 2009 May; 100(5):896-902.
358
Tu SP, Liston P, Cui JT, Lin MC, Jiang XH, Yang Y, Gu Q, Jiang SH, Lum CT, Kung HF,
Korneluk RG, Wong BC. Restoration of XAF1 expression induces apoptosis and inhibits tumor
growth in gastric cancer. Int J Cancer. 2009 Jan 22; 125(3):688-697.
359
Zhang JF, Li G, Meng CL, Dong Q, Chan CY, He ML, Leung PC, Zhang YO, Kung HF. Total
flavonoids of Herba Epimedii improves osteogenesis and inhibits osteoclastogenesis of human
mesenchymal stem cells. Phytomedicine. 2009 Jun; 16(6-7):521-9
360
Zhu X, Chen MS, Tian LW, Li DP, Xu PL, Lin MC, Xie D, Kung HF Single nucleotide
polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary
hepatocellular carcinoma in Han Chinese: Risk and prognosis. Int J Cancer. 2009; 125: 1352-7
361
Au WS, Lu LW, Tam S, Ko OK, Chow BK, He ML, Ng SS, Yeung CM, Liu CC, Kung HF, Lin
MC. Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional
regulation of microsomal triglyceride transfer protein. World J Gastroenterol. 2009 Jun 28;
15(24):2987-94.
362
He ML, Zheng BJ, Chen Y, Wong KL, Huang JD, Lin MC, Yuen KY, Sung JJ, Kung HF
Development of interfering RNA agents to inhibit SARS-associated coronavirus infection and
replication. Hong Kong Med J. 2009 Jun; 15(3 Suppl 4):28-31.
363
Dong Q, Liu Z, Chen Y, Chan CY, Lin MC, Kung HF, Chan HL, Sung JJ, He ML. High level
virion production and surface antigen expression with 1.5 copies of hepatitis B viral genome. J
Virol Methods. 2009 Aug; 159(2):135-40.
364
Liang B, He ML, Chan CY, Chen YC, Li XP, Li Y, Zheng D, Lin MC, Kung HF, Shuai XT,
Peng Y. The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of
glioma growth in the rat. Biomaterials. 2009 Aug; 30(23-24):4014-20.
365
Ling Xiao Liu, Nikki P. Lee, Vivian W. Chan, Wen Xue, Lars Zender, Chunsheng Zhang, Mao
Mao, Hongyue Dai, Xiao Lin Wang, Michelle Z. Xu, Terence K. Lee, Irene O. Ng., Yangchao
Chen, Hsiang-fu Kung, Scott W. Lowe, Ronnie T. P. Poon, Jian Hua Wang, and John M. Luk
Targeting Cadherin-17 Inactivate Wnt Signaling and Inhibits Tumor Growth in Liver Carcinoma
Hepatology. 2009 Nov; 50(5):1453-63.
366
Li M, Wang J, Ng SS, Chan CY, He ML, Yu F, Lai L, Shi C, Chen Y, Yew DT, Kung HF, Lin
MC. Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factorinduced glioblastoma cell proliferation. Cancer. 2009 Nov 1; 115(21):4959-72
367
Yan Ma, Jun Yu, Henry L.Y. Chan, Yang-chao Chen, Hua Wang, Ying Chen, Chu-yan Chan,
Minnie Y. Y. Go, Sau-na Tsai, Sai-ming Ngai, Ka-fai To, Joanna H. M. Tong, Qing-yu He,
Joseph J. Y. Sung, Hsiang-fu Kung, Christopher H. K. Cheng, and Ming-liang He Glucose-
34
Hsiang-fu Kung, Ph.D.
Regulated Protein 78 Is an Intracellular Antiviral Factor against Hepatitis B Virus Mol Cell
Proteomics 2009; 8:2582-2594
368
Jin-fang Zhang, Guo Li, Chu-yan Chan, Chun-ling Meng, Marie Chia-mi Lin, Yang-chao Chen,
Ming-liang He, Ping-chung Leung and Hsiang-fu Kung Flavonoids of Herba Epimedii regulate
osteogenesis of human mesenchymal stem cells through BMP and Wnt/B-catenin signaling
pathway Molecular and Cellular Endocrinology. 2010 Jan 15; 314(1):70-4. Epub 2009 Aug 22.
369
Guo-Qing Wu, Dan Xie, Guo-Feng Yang, Yi-Ji Liao, Shi-Juan Mai, Hai-Xia Deng, Johnny Sze,
Xin-Yuan Guan, Yi-Xin Zeng, Marie C. Lin and Hsiang-fu Kung Cell cycle-related kinase
supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of
outcome in patients with ovarian carcinoma Int. J. Cancer, 2009 Dec 1; 125(11):2631-42.
370
Xiao Zhu, Min-Shan Chen, Lin-Wei Tian, Dong-Pei Li, Pei-Lin Xu, Marie C. M. Lin, Dan Xie
and Hsiang-fu Kung Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78
gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: Risk and
prognosis Int. J. Cancer 2009; 125(6):1352-1357
371
Rui Deng, Yanan Yue, Fan Jin, Yangchao Chen, Hsiang-fu Kung, Marie C.M. Lin and Chi Wu
Revisit the complexation of PEI and DNA – How to make low cytotoxic and high efficient PEI
gene transfection non-viral vectors with a controllable chain length and structure? Journal of
Controlled Release, 2009 Nov 16; 140(1):40-6. Epub 2009 Jul 19.
372
Li G, Zhang XA, Zhang JF, Chan CY, Yew DT, He ML, Lin MC, Leung PC, Kung HF Ethanol
extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells Phytother
Res. 2010 Apr; 24(4):571-6.
373
Yao H, Ng SS, Tucker WO, Tsang YK, Man K, Wang XM, Chow BK, Kung HF, Tang GP, Lin
MC
The gene transfection efficiency of a folate-PEI600-cyclodextrin nanopolymer.
Biomaterials. 2009 Oct; 30(29):5793-803.
374
Tu S, Wai-Yin Sun R, Lin MC, Tao Cui J, Zou B, Gu Q, Kung HF, Che CM, Wong BC. Gold
(III) porphyrin complexes induce apoptosis and cell cycle arrest and inhibit tumor growth in
colon cancer. Cancer. 2009 Oct 1; 115(19):4459-69.
375
He LR, Liu MZ, Li BK, Jia WH, Zhang Y, Liao YJ, Chen YC, Zhang LJ, Guan XY, Zeng YX,
Kung HF, Xie D. High expression of EZH2 is associated with tumor aggressiveness and poor
prognosis in patients with esophageal squamous cell carcinoma treated with definitive
chemoradiotherapy. Int J Cancer. 2010 Jul 1; 127(1):138-47
376
Zhu X, Wang Y, Tao T, Li DP, Lan FF, Zhu W, Xie D, Kung HF. A new polymorphism in the
GRP78 is not associated with HBV invasion. World J Gastroenterol. 2009 Oct 21; 15(39):495861.
35
Hsiang-fu Kung, Ph.D.
377
Chen SC, Lu G, Chan CY, Chen Y, Wang H, Yew DT, Feng ZT, Kung HF. Microarray Profile
of Brain Aging-Related Genes in the Frontal Cortex of SAMP8. J Mol Neurosci. 2010 May;
41(1):12-6. Epub 2009 Oct 17.
378
Yeung CM, Tan Y, Tam S, Lu L, Ko KH, Yang PH, Kung HF, Lin MC. The antidiabetic effects
of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice. Biologics. 2008
Sep; 2(3):571-6.
379
Xia H, Ng SS, Jiang S, Cheung WK, Sze J, Bian XW, Kung HF, Lin MC. miR-200a-mediated
downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell
growth, migration and invasion. Biochem Biophys Res Commun. . [Epub ahead of print]
380
Tu SP, Sun YW, Cui JT, Zou B, Lin MC, Gu Q, Jiang SH, Kung HF, Korneluk RG, Wong BC.
Tumor suppressor XIAP-Associated factor 1 (XAF1) cooperates with tumor necrosis factorrelated apoptosis-inducing ligand to suppress colon cancer growth and trigger tumor regression.
Cancer. 2010 Mar 1; 116(5):1252-63.
381
He LR, Zhao HY, Li BK, Zhang LJ, Liu MZ, Kung HF, Guan XY, Bian XW, Zeng YX, Xie D
Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung
cancer patients. Ann Oncol. 2010 Aug; 21(8):1675-81. Epub 2010 Jan 11.
382
Zhu X, Fan W, Li D, Lin MC, Kung H Heme oxygenase-1 system and gastrointestinal tumores.
World J Gastroenterol 2010 in press
383
Wai MS, Liang Y, Shi C, Cho EY, Hung HF, Yew DT Co-localization of hyperphosphorylated
tau and caspases in the brainstem of Alzherimer’s disease patients. Biogerontology. 2009
Aug;10(4):457-69. Epub 2008 Oct 23.
384
Qingming Dong, Bingying Xu, Yi Tan, Zheng Liu, Linwei Tian, Bao Zhang, Che-kit Lin,
Hsiang-fu Kung Joseph JY Sung, Ming-liang He The genetic variability of MDR1 C3435T
polymorphisms in four Southern Chinese populations. Biomedicine & Pharmacotherapy 2009
Nov;63(9):658-62. Epub 2008 Sep 25.
385
Zhang JF, He ML, Dong Q, Xie WD, Chen YC, Lin MC, Leung PC, Zhang YO, Kung HF.
Aqueous Extracts of Fructus Ligustri Lucidi Enhance the Sensitivity of Human Colorectal
Carcionma DLD-1 Cells to Doxorubicin-Induced Apoptosis via Tbx3 Suppression. Integr
Cancer Ther. 2010 Aug 11. [Epub ahead of print]
386
Chen Y, Xie D, Yin Li W, Man Cheung C, Yao H, Chan CY, Chan CY, Xu FP, Liu YH, Sung JJ,
Kung HF. RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer
in vivo. Cancer Lett. 2010 Nov 1; 297(1):109-16. Epub 2010 Jun 1.
387
Peng K, Li Y, Long L, Li D, Jia Q, Wang Y, Shen Q, Tang Y, Wen L, Kung HF, Peng Y.
Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in
zebrafish. Neurosci Lett. 2010 Oct 29; 484(2):98-103. Epub 2010 Jul 30.
36
Hsiang-fu Kung, Ph.D.
388
Rao ZY, Cai MY, Yang GF, He LR, Mai SJ, Hua WF, Liao YJ, Deng HX, Chen YC, Guan XY,
Zeng YX, Kung HF, Xie D. EZH2 supports ovarian carcinoma cell invasion and/or metastasis
via regulation of TGF-{beta}1 and is a predictor of outcome in ovarian carcinoma patients.
Carcinogenesis. 2010 Sep; 31(9):1576-83. Epub 2010 Jul 28.
389
Liu AM, Lu G, Tsang KS, Li G, Wu Y, Huang ZS, Ng HK, Kung HF, Poon WS. Umbilical
cord-derived mesenchymal stem cells with forced expression of hepatocyte growth factor
enhance remyelination and functional recovery in a rat intracerebral hemorrhage model.
Neurosurgery. 2010 Aug; 67(2):357-65; discussion 365-6.
390
Lu J, Li XP, Dong Q, Kung HF, He ML. TBX2 and TBX3: The special value for anticancer
drug targets. Biochim Biophys Acta. 2010 Dec; 1806(2):268-74. Epub 2010 Jul 17.
391
Li XY, Chen YC, Zhou KY, Zhang MH, Luo HQ, Kung HF, Zhou X. Overexpression of Bax
inhibitor-1 (BI-1) induces cell transformation in NIH3T3 cells. Cell Biol Int. 2010 Jul 2. [Epub
ahead of print]
392
Wang Y, Liu YH, Mai SJ, He LJ, Liao YJ, Deng HX, Guan XY, Zeng YX, Kung HF, Xie D.
Evaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with
hepatitis B virus related cirrhosis. J Gastroenterol Hepatol. 2010 Jun; 25(6):1123-8.
393
Zhu X, Li DP, Fan WG, Lin MC, Wang JL, Lin SQ, Huang JQ, Kung HF. Lack of association
between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic
HBV infection in a Chinese Han population. BMC Med Genet. 2010 Jun 2; 11:83.
394
Yeung LY, Kung HF, Yew DT. Localization of 5-HT1A and 5-HT2A positive cells in the
brainstems of control age-matched and Alzheimer individuals. Age (Dordr). 2010 Dec;
32(4):483-95. Epub 2010 May 28
395
An X, Ng SS, Xie D, Zeng YX, Sze J, Wang J, Chen YC, Chow BK, Lu G, Poon WS, Kung HF,
Wong BC, Lin MC. Functional characterisation of cell cycle-related kinase (CCRK) in
colorectal cancer carcinogenesis. Eur J Cancer. 2010 Jun; 46(9):1752-61.
396
Guo BH, Zhang X, Zhang HZ, Lin HL, Feng Y, Shao JY, Huang WL, Kung HF, Zeng MS. Low
expression of Mel-18 predicts poor prognosis in patients with breast cancer. Ann Oncol. 2010
Dec; 21(12):2361-9. Epub 2010 May 5.
397
Wu GQ, Liao YJ, Qin ZQ, He LR, Chen YC, Zeng YX, Kung HF, Xie D. PYRIN domain of
NALP2 inhibits cell proliferation and tumor growth of human glioblastoma. Plasmid. 2010 Jul;
64(1):41-50.
398
Hua WF, Fu YS, Liao YJ, Xia WJ, Chen YC, Zeng YX, Kung HF, Xie D. Curcumin induces
down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human
breast cancer cells. Eur J Pharmacol. 2010 Jul 10; 637(1-3):16-21.
37
Hsiang-fu Kung, Ph.D.
399
Cai MY, Zhang B, He WP, Yang GF, Rao HL, Rao ZY, Wu QL, Guan XY, Kung HF, Zeng YX,
Xie D. Decreased expression of PinX1 protein is correlated with tumor development and is a
new independent poor prognostic factor in ovarian carcinoma. Cancer Sci. 2010 Jun;
101(6):1543-9.
400
Lan FF, Wang H, Chen YC, Chan CY, Ng SS, Li K, Xie D, He ML, Lin MC, Kung HF. Hsa-let7g inhibits proliferation of hepatocellular carcinoma Cells by down-regulation of c-Myc and Upregulation of p16(INK4A). Int J Cancer. 2011, Jan 15; 128(2):319-31. doi: 10.1002/ijc.25336.
Epub 2010 Mar 22.
401
Jiang L, Chen Y, Chan CY, Lu G, Wang H, Li JC, Kung HF. Dynamic transcriptional changes
of TIEG1 and TIEG2 during mouse tissue development. Anat Rec (Hoboken). 2010 May;
293(5):858-64.
402
Cheung WK, Yang PH, Huang QH, Chen Z, Chen SJ, Lin MC, Kung HF. Identification of
protein domains required for makorin-2-mediated neurogenesis inhibition in Xenopus embryos.
Biochem Biophys Res Commun. 2010 Mar 26; 394(1):18-23.
403
Lum CT, Liu X, Sun RW, Li XP, Peng Y, He ML, Kung HF, Che CM, Lin MC. Gold(III)
porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration
and invasion in vitro. Cancer Lett. 2010 Aug 28; 294(2):159-66.
404
Cai MY, Hou JH, Rao HL, Luo RZ, Li M, Pei XQ, Lin MC, Guan XY, Kung HF, Zeng YX, Xie
D. High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with
vascular invasion and predicts patients worse prognosis. Mol Med. 2011 Jan-Feb; 17(1-2):12-20.
Epub 2010 Sep 10.
405
Yu F, Ng SS, Chow BK, Sze J, Lu G, Poon WS, Kung HF, Lin MC. Knockdown of interferoninduced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of
glioma cells. J Neurooncol. 2010 Sep 14. [Epub ahead of print]
406
Xia H, Cheung WK, Sze J, Lu G, Jiang S, Yao H, Bian XW, Poon WS, Kung HF, Lin MC. miR200a regulates epithelial-mesenchymal to stem-like transition via ZEB2 and [beta]-catenin
signaling. J Biol Chem 2010 Nov 19; 285(47):36995-7004.
407
Yue Y, Jin F, Deng R, Cai J, Chen Y, Lin MC, Kung HF, Wu C Revisit complexation between
DNA and polyethylenimine - Effect of uncomplexed chains free in the solution mixture on gene
transfection. J Control Release. 2010 Nov 3. [Epub ahead of print]
408
He J, Zhang JF, Yi C, Lv Q, Xie WD, Li JN, Wan G, Cui K, Kung HF, Yang J, Yang BB, Zhang
Y. miRNA-mediated functional changes through co-regulating function related genes. PLoS
One. 2010 Oct 22; 5(10):e13558.
409
Lin S, Cheung WK, Chen S, Lu G, Wang Z, Xie D, Li K, Lin MC, Kung HF. Computational
identification and characterization of primate-specific microRNAs in human genome. Comput
Biol Chem. 2010 Aug; 34(4):232-41. Epub 2010 Aug 24.
38
Hsiang-fu Kung, Ph.D.
410
Diao S, Zhang JF, Wang H, He ML, Lin MC, Chen Y, Kung HF. Proteomic identification of
microRNA-122a target proteins in hepatocellular carcinoma. Proteomics. 2010 Oct; 10
(20):3723-31.
411
Huo L, Yao H, Wang X, Wong GW, Kung HF, Lin MC. Inhibition of melanoma growth by
subcutaneous administration of hTERTC27 viral cocktail in C57BL/6 mice. PLoS One. 2010
Sep 13; 5(9):e12705.
412
Cheng XW, Lu J, Wu CL, Yi LN, Xie X, Shi XD, Fang SS, Zan H, Kung HF, He ML. Three
fatal cases of pandemic 2009 influenza A virus infection in Shenzhen are associated with
cytokine storm. Respir Physiol Neurobiol. 2011 Jan 31; 175(1):185-7. Epub 2010 Nov 11.
413
Lum CT, Huo L, Sun RW, Li M, Kung HF, Che CM, Lin MC. Gold(III) porphyrin 1a prolongs
the survival of melanoma-bearing mice and inhibits angiogenesis. Acta Oncol. 2010 Nov 29.
[Epub ahead of print]
414
Lu J, He ML, Wang L, Chen Y, Liu X, Dong Q, Chen YC, Peng Y, Yao KT, Kung HF, Li XP.
MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression
of EZH2. Cancer Res. 2011 Jan 1; 71(1):225-33.
415
Guo BH, Feng Y, Zhang R, Xu LH, Li MZ, Kung HF, Song LB, Zeng MS. Bmi-1 promotes
invasion and metastasis, and its elevated expression is correlated with an advanced stage of
breast cancer. Mol Cancer. 2011 Jan 28; 10(1):10.
416
Li G, Chan CY, Wang H, Kung HF. Proteomic Analysis of Human Mesenchymal Stem Cells
Methods Mol Biol. 2011;698: 443-457.
417
Cai MY, Tong ZT, Zheng F, Liao YJ, Wang Y, Rao HL, Chen YC, Wu QL, Liu YH, Guan XY,
Lin MC, Zeng YX, Kung HF, Xie D. EZH2 protein: a promising immunomarker for the
detection of hepatocellular carcinomas in liver needle biopsies. Gut. 2011 Feb 17. [Epub ahead
of print]
418
Jiang L, Lai YK, Zhang J, Wang H, Lin MC, He ML, Kung HF. Targeting S100P inhibits colon
cancer growth and metastasis by lentivirus-mediated RNA interference and proteomic analysis.
Mol Med. 2011 Feb 9. [Epub ahead of print]
419
Yi L, He Y, Chen Y, Kung HF, He ML. Potent inhibition of human enterovirus 71 replication
by type I interferon subtypes. Antivir Ther. 2011;16(1):51-8.
420
Li D, Zhao Y, Liu C, Chen X, Qi Y, Jiang Y, Zou C, Zhang X, Liu S, Wang X, Zhao D, Sun Q,
Zeng Z, Dress A, Lin MC, Kung HF, Rui H, Liu LZ, Mao F, Jiang BH, Lai L. Analysis of MiR195 and MiR-497 Expression, Regulation and Role in Breast Cancer. Clin Cancer Res. 2011
Mar 22. [Epub ahead of print]
39
Hsiang-fu Kung, Ph.D.
Patents :
1.
2.
3.
4.
Method for the extraction of immune interferon US Patent 4476049 issued on October 9, 1984
Homogeneous immune interferon fragment US Patent 4604284 issued on August 5, 1986
Crystalline human leukocyte interferon US Patent 4672108 issued on June 9, 1987
Immune interferon and a method for its extraction and purification US Patent 4681930 issued on
July 21, 1987
5. Immune interferon US Patent 5278286 issued on January 11, 1994
6. Anti-HIV proteins GAP 31, DAP 30 and DAP 32 and therapeutic uses thereof US Patent
5317009 issued on May 31, 1994
7. Plant protein useful for treating tumors and HIV infection US Patent 5484889 issued on
January 16, 1996
8. Anti-HIV protein, TAP 29, from tricosanthes, DNA coding therefor and therapeutic uses thereof
US Patent 5532214 issued on July 2, 1996
9. Recombinant immune interferon having an intact carboxyl terminus US Patent 5593667 issued
on January 14, 1997
10. Inhibition of human immunodeficiency virus-1 infectivity in human cells US Patent 5668149
issued on September 16, 1997
11. Inhibition of hepatitis B virus (HBV) replication by RNA interference US Patent 7067249
issued on June 27, 2006
12. Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA
interference US Patent 7129223 issued on October 31, 2006
13. Telomerase reverse transcriptase fragments and uses thereof US Patent 7294708 issued on
November 13, 2007
14. Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA
interference US Patent 7429656 issued on September 30, 2008
Books and Book Chapters :
1.
2.
3.
4.
5.
Staehelin, T., Hobbs, D., Kung, H.F., and Pestka, S.: Purification of recombinant human
leukocyte interferon with the use of monoclonal antibodies. In Pestka, S. (Ed.): Methods in
Enzymology. New York, Academic Press, 1981, 78A:505-512.
Miller, D., Kung, H.F., Staehelin, T., and Pestka, S.: Crystallization of recombinant human
leukocyte interferon A. In Pestka, S. (Ed.): Methods in Enzymology. New York, Academic
Press, 1981, 79B:3-7.
Kung, H.F.: Role of L factor in coupled transcription and translation. In Schlessinger, D. (Ed.):
Microbiology. Washington, D.C., Am. Soc. Microbiol., 1983, 53-56.
Pestka, S., Kung, H.F., Durrer, B., Schmidt, J., and Staehelin, T.: Monoclonal antibodies to the
interferons: Their use in assay and purification. In Vilcek, J., De Mayer, E. (Eds.): Interferons
and the Immune System. Amsterdam, The Netherlands, Elsevier Science Publishers, B.V., 1984,
pp. 249-262.
Kung, H.F., Boublik, M., Manne, V., Yamazaki, S., and Garcia, E.: Bacterial gene expression
and biotechnology. In Chock, P.B. (Ed.): Current Topics in Cellular Regulation. New York,
Academic Press, 1985, 26:531-542.
40
Hsiang-fu Kung, Ph.D.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Petska, S., Rashidbaigi, A., Langer, J.A., Mariano, T.M., Kung, H.F., Jones, C., and Tischfield,
J.A.: Interferon gamma (IFN-) receptors. UCLA Symposium on Molecular and Cellular
Biology, New Series. In Friedman, R.M., Merigan, T.M., Sreevalsan, T. (Eds.): Interferon as
Cell Growth Inhibitors and Antitumor Factors. Austin Texas, University of Texas Press,
Volume 50:259-268, 1986, pp. 541.
Kung, H.F., et al.: Purification of recombinant human immune interferon. In Pestka, S. (Ed.):
Methods in Enzymology, Interferons, Part C. New York, Academic Press, 1986, pp. 204-210.
Kung, H.F.: Labeling of interferons with (35S) methionine in a cell-free DNA dependent system.
In Pestka, S. (Ed.): Methods in Enzymology, Interferons, Part C. New York, Academic press,
1986, pp. 292-296.
Kung, H.F. and Bekesi, E.: Phosphorylation of human immune interferon. In Pestka, S. (Ed.):
Methods in Enzymology, Interferons, Part C. New York, Academic Press, 1986, pp. 296-301.
Lavu, S., Kung, H.F., Angus, C.W., Van Meurs, K.P., Price, S.R., Tsai, S.C., Adamik, R.,
Czarnecki, S.K., Moss, J., and Vaughan, M.: Nucleotide and deduced amino acid sequences of a
cDNA clone for bovine Go-: Similarities to other guanyl nucleotide-binding proteins. In Kno,
O.L. et al. (Eds.): Contemporary Themes in Biochemistry. ICSU Press, 1986, pp. 412-413.
Smith, M.R., Young, H.A., Kung, H.F., and Durum, S.K.: Intracellular activities of
microinjected cytokines and lymphokines. In Kaplan, J.G., (Ed.): The Cellular Basis of Immune
Modulation. New York, Alan R. Liss, 1988, pp. 261-264.
Kung, H.F.: Biotechnology and Cancer Research. In Ting, S.W., Chen, J.S., and Schwarze, M.K.
(Ed.): Human Tumor Markers. Elsevier Science Publishers B. V. (Biochemical Division), 1989,
pp. 231-243.
Kung, H.F., Wei, C., Bekesi, E., Lowy, D., and Willumsen, B.: Solubility of recombinant
proteins expressed in E. coli. In Villafranca, J. (Ed.): Current Research in Protein Chemistry.
New York, Academic Press, 1990, pp. 467-478.
Lee-Huang, S., Chen, H.C., Kung, H.F., Huang, P.L., Nara, P., Li, B.Q., Huang, P., Huang, H.I.,
and Huang, P.L.: Plant proteins with activity against human immunodeficiency virus. In C.K.
Chu and H.G. Cutler (Eds.): Natural Products As Antiviral Agents. New York, Plenum Press, pp.
153-170, 1992.
Gene Therapy of HBV Infection Via Adeno-Associated Viral Vector Medicated Long Term
Expression of Small Hairpin RNA (shRNA), U.S. CIP Patent Application No. 11/451,876
Research Grants (after joined CUHK) :
Titles
South China National Research Center for Integrated
Biosciences in Collaboration with Zhongshang University
Research Into Integrative Medical Sciences – CEID
Novel Anti-HIV Drug: A Cyclosporine Analog
Development of Novel Polymeric Vectors for Gene
Transfer
Function and regulation of ADP-ribosylation factor 6
(ARF6) in EGF mediated glioblastoma cell proliferation
Stem cell research
Funding Sources
Focused
Investments
Scheme
LiHS
AIDS Trust Fund
Focused
Investments
Scheme
RGC
Amount (HK$)
1,240,208
863 Programme
Key Project 2007
年深港創新圈專
41
Period
7/05 – 6/08
842,220
715,553
1,000,000
11/05 – 12/10
5/06 – 31/10/07
15/8/06 – 31/12/09
1,306,934
9/07 – 8/10
RMB
350,000
2007 - 2012
Hsiang-fu Kung, Ph.D.
Technical Support for the Isolation of Mesenchymal Stem
Cells from Wharton’s Jelly of Umbilical Cord of New Born
Baby - Healthbaby Biotech (HK) Co Ltd
Regulation of tumor associated genes by EZH2 in
hepatocellular carcinoma
Funding Support for State Key Laboratory (SKL) in
Oncology in South China
Proteomic identification of proteins implicated in the
migration of human mesenchymal stem cells
Functional characterization of microRNAs associated with
glioma carcinogenesis
惡性肿瘤非編码 RNA 相关蛋白的功能
網絡與調控機制的研究
The gene expression profiles of CD4 and CE8 T cells in
influenza infected patients
Identification of super interferon against EV71 virus
A new vaccine against EV71: dendritic cell specific
vaccination
Evaluation of novel non-immunosuppressive cyclosporines
as potential antiviral agents against enterovirus EV71
Functions of Proteins related to post-transcriptional
processing of tumour non-coding RNAs
項資金資助計划
Agreement
100,000
25/1/08 – 24/1/10
Direct Fund
100,000
2/08 – 1/09
Block Grant
500,000
2008-09 yearly
Director Grant
30,000
29/6/09 – 28/6/10
RGC
1,039,170
11/09 – 10/12
973 囯家重大科
学研究計划
RFCID 2nd
Commissioned
Studies
RFCID 2nd
Commissioned
Studies
RFCID 2nd
Commissioned
Studies
RFCID 2nd
Commissioned
Studies
RAC
RMB
2,000,000
2010 - 2015
700,000
1/10 – 12/13
400,000
4/10 – 3/12
400,000
7/10 – 6/13
400,000
4/10 – 3/13
1,279,440
2/10 – 3/13
42