RADR 2213 // \\ LESSON PLAN
RADIATION BIOLOGY AND PROTECTION
33. HUMAN BIOLOGY
A. HUMAN RADIATION RESPONSE
B. COMPOSITION OF THE BODY
1. CELL THEORY
2. MOLECULAR COMPOSITION
3. THE HUMAN CELL
4. TISSUES AND ORGANS
34.
FUNDAMENTAL PRINCIPLES OF RADIOBIOLOGY
A. LAW OF BERGONIE AND TRIBONDEAU
B. PHYSICAL FACTORS AFFECTING RADIOSENSITIVITY
1. LINEAR ENERGY TRANSFER
2. RELATIVE BIOLOGIC EFFECTIVENESS
3. PROTRACTION AND FRACTIONATION
C. BIOLOGICAL FACTORS AFFECTING RADIOSENSITIVITY
1. OXYGEN EFFECT
2. AGE
3. RECOVERY
4. CHEMICAL AGENTS
5. HORMESIS
D. RADIATION DOSE RESPONSE RELATIONSHIPS
1. LINEAR DOSE RESPONSE RELANTIONSHIPS
2. NONLINEAR DOSE RESPONSE RELATIONSHIPS
3. CONTRUCTING A DOSE RESPONSE RELATIONSHIP
35. MOLECULAR AND CELLULAR RADIOBIOLOGY
A. IRRADIATION OF MACROMOLECULES
1. MAIN CHAIN SCISSION
2. CROSS LINKING
3. POINT LESIONS
4. MACROMOLECULAR SYNTHESIS
5. RADIATION EFFECTS ON DNA
B. RADIOLYSIS OF WATER
C. DIRECT AND INDIRECT EFFECT
D. TARGET THEORY
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E. CELL SURVIVAL KINETICS
1. SINGLE TARGET, SINGLE HIT MODEL
2. MULTI TARGET, SINGLE HIT MODEL
3. RECOVERY
4. CELL CYCLE EFFECTS
5. LINEAR ENERGY TRANSFER, RELATIVE BIOLOGIC EFFECTIVENESS, AND
OXYGEN ENHANCEMENT RATIO
36. EARLY EFFECTS OF RADIATION
A. ACUTE RADIATION LETHALITY
1. PRODROMAL PERIOD
2. HEMATOLOGIC SYNDROME
3. GASTROINTESTINAL SYNDROME
4. CENTRAL NERVOUS SYSTEM SYNDROME
5. LD
6. MEAN SURVIVAL TIME
B. LOCAL TISSUE DAMAGE
1. EFFECTS ON SKIN
2. EFFECTS ON GONADS
C. HEMATOLOGIC EFFECTS
1. HEMOPOIETIC SYSTEM
2. HEMOPOIETIC CELL SURVIVAL
D. CYTOGENETIC EFFECTS
1. NORMAL KARYOTYPE
2. SINGLE HIT CHROMOSOME ABERRATIONS
3. MULTI HIT CHROMOSOME ABERRATIONS
4. KINETICS OF CHROMOSOME ABERRATIONS
37. LATE EFFECTS OF RADIATION
A. LOCAL TISSUE EFFECTS
1. SKIN
2. CHROMOSOMES
3. CATARACTS
B. LIFE SPAN SHORTENING
C. RISK ESIMATES
1. RELATIVE RISK
2. EXCESS RISK
3. ABSOLUTE RISK
D. RADIATION INDUCED MALIGNANCY
1. LEUKEMIA
2. CANCER
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E. TOTAL RISK OF MALIGNANCY
1. THREE MILE ISLAND
2. BEIR COMMITTEE
F. RADIATION AND PREGNANCY
1. EFFECTS ON FERTILITY
2. IRRADIATION IN UTERO
3. GENETIC EFFECTS
38. HEALTH PHYSICS
A. CARDINAL PRINCIPLES OF RADIATION PROTECTION
1. MINIMIZE TIME
2. MAXIMIZE DISTANCE
3. MAXIMIZE SHIELDING
B. DOSE LIMTS
1. WHOLE BODY DOSE LIMITS
2. DOSE LIMITS FOR TISSUES AND ORGANS
3. PUBLIC EXPOSURE
4. EDUCATIONAL CONSIDERATIONS
C. X-RAYS AND PREGNANCY
1. RADIOBIOLOGIC CONDIDERATIONS
2. PREGNANT TECHNOLOGIST
3. MANAGEMENT PRINCIPLES
4. PREGNANT PATIENT
39. DESIGNING FOR RADIATION PROTECTION
A. RADIOGRAPHIC PROTECTION FEATURES
1. SOURCE TO IMAGE RECEPTOR DISTANCE INDICATOR
2. COLLIMATION
3. POSITIVE BEAM LIMITATION
4. BEAM ALIGNMENT
5. FILTRATION
6. REPRODUCIBILITY
7. LINEARITY
8. OPERATOR SHIELD
9. MOBILE X-RAY IMAGING SYSTEM
B. FLOUROSCOPIC PROTECTON FEATURES
1. SOURCE TO SKIN DISTANCE
2. PRIMARY PROTECTIVE BARRIER
3. FILTRATION
4. COLLIMATION
5. EXPOSURE CONTROL
6. BUCKY SLOT COVER
7. PROTECTIVE CURTAIN
8. CUMULATIVE TIMER
9. DOSE AREA PRODUCT
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C. DESIGN OF PROTECTIVE BARRIERS
1. TYPE OF RADIATION
2. FACTORS AFFECTING BARRIER THICKNESS
D. RADIATION DETECTION AND MEASUREMENT
1. GAS FILLED DETECTORS
2. SCINTILLATION DETECTORS
3. THERMOLUNINESCENCE DOSIMETRY
4. OPTICALLY STIMULATED LUMINESCENCE
40. RADIATION PROTECTION PROCEDURES
A. OCCUPATIONAL RADIATION EXPOSURE PATIENT DOSE
1. ESTIMATION OF PATIENT DOSE
2. PATIENT DOSE IN SPECIAL EXAMINATIONS
B. REDUCTION OF OCCUPATIONAL RADIATION EXPOSURE
1. PERSONNEL MONITORING
2. PERSONNEL MONITORING REPORT
3. PROTECTIVE APPAREL
4. POSITION
5. PATIENT HOLDING
C. REDUCTION OF UNNECESSARY PATIENT DOSE
1. UNNECESSARY EXAMINATIONS
2. REPEAT EXAMINATIONS
3. RADIOGRAPHIC TECHNIQUE
4. IMAGE RECEPTOR
5. PATIENT POSITIONING
6. SPECIFIC AREA SHIELDING
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