55. Synthesis and biological evaluation of new benzothiazoles as

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CURRICULUM VITAE
Name
: Mahmoud Y. Al-Talib
Rank
: Professor in Organic Chemistry
Present Address
: Department of Chemistry
Yarmouk University
Irbid - Jordan
Tel. 7211111 ext. 3771; E-Mail: mahmoud_talib@yahoo.com,
Mahmoud_talib@yu.edu.jo
Permanent Address
: Irbid, JORDAN; Tel. (00962)-2- 7104377,
mobile : 0777461247
Date of Birth
: 6.11.1957 3
Place of Birth
: Al-Manshieh, JORDAN
Nationality
: Jordanian
Marital Status
: Married
Number of Children
:5
Education :
Degree
University
Year
Language
 B.Sc. (Chem.)
Jordan Univ. / Amman
1976
English
 M.Sc. (Chem.)
Jordan Univ. / Amman
1978
English
 Ph.D.(Org.Chem)
Konstanz Univ./Germany
1984
English / German
Titles of Theses :
 Kinetics and Mechanisms of the reaction of some Iridium(I) complexes with various
Ligands. (M.Sc.)
 Syntheses, Structure and Reactions of new Classes of Heterocumulenes (Ph.D.).
Teaching Experience:
 Research and Teaching Assistant (1978 - 1980) - Department of Chemistry - Yarmouk
University. Teaching different classes of practical organic chemistry.
 Assistant Professor (1.9.1984 - 1.2.1989(.
 Associate Professor (1.2.1989 - 2.10.1993) - Department of Chemistry – Yarmouk
University.
 Visiting Professor (1. 9. 1990 - 31. 8. 1991) , Konstanz University - Germany
 Professor (3.10.1993 – 12.9.1998) - Department of Chemistry - Yarmouk University.
 Professor (13.9.1998 – 12.9.9.1999) - Department of Chemistry, Al al-byet University
Mafraq/Jordan.
 Professor (13.9.1999 – 11.9.2004) - Department of Chemistry - Yarmouk University.
 Professor (12.9.2004 – 13.9.2005)- Faculty of Pharmacy – Al-Zaytoonah University,
Amman / Jordan.
 Professor (14.9.2005 – till now)- Department of Chemistry - Yarmouk University.
 Chairman of the Chemistry Department – Yarmouk University ( 2006 – 2008).
Teaching the following courses:
 Chem. 101 General Chemistry (1).
 Chem. 102 General Chemistry (2).
 Chem. 105 Practical General Chemistry (1).
 Chem. 106 Practical General Chemistry (2).
 Chem. 211 Organic Chemistry (I).
 Chem. 212 Organic Chemistry (II).
 Chem. 213 Practical Organic Chemistry (I).
 Chem. 214 Practical Organic Chemistry (II).
 Chem. 215 Organic Chemistry for Non-Majors.
 Chem. 216 Practical Organic Chemistry for Non-Majors.
 Chem. 217 Organic Chemistry for medicine students (JUST University).
 Chem. 218 Practical Organic Chemistry for medicine (JUST University).
 Chem. 311 Organic Chemistry (III).
 Chem. 312 Systematic Identification of Organic Compounds.
 Chem. 413 Heterocyclic Chemistry.
 Chem. 415 Names in Organic Chemistry.
 Chem. 495 Special Topics in Organic Synthesis.
 Biochemistry for medical colleges, Irbid.
 Pharmaceutical Organic chemistry – Alzytoonah University.
 Chem. 611Advanced Organic Chemistry.
 Chem. 612 Organic Synthesis.
 Chem.613 Advanced Heterocyclic Chemistry
 Chem. 695 Special Topics in Organic Chemistry.
Research Interest :
 Mechanistic organic chemistry, with special reference to Heterocumulenes and reactive
species in Organic Chemistry.
 Synthetic organic chemistry, with special interest on synthesis of Heterocyclic ring
systems.
Membership of Examining Committees for Graduate Students:
 Member of the examining committee of Mss.Hadeeth Al-Atetat(2012(.
 Member of the examining committee of Mss.Hadeel Al-Sinjilawi(2011(.
 Member of the examining committee of Mss.Marwa Abu-Aisheh.(2011(.
 Chairman of the examining committee of Mss. Fatmeh Abu-sahyoon(2010(.
 Chairman of the examining committee of Mss. Safaa Khashashneh(2010(.
 Member of the examining committee of Mr. M. Ababneh(2010(.
 Member of the examining committee of Mrs. R. Al-Nimry (2010(.
 Member of the examining committee of Mrs. Reem Ahmad, al Abiet Uni (2008(.
 Chairman of the examining committee of Mrs. Manal Elian(2006(.
 Member of the examining committee of Mrs. R. Al-Nimry (2007(.
 Chairman of the examining committee of Mr. Mohanad Shkour(2005(.
 Chairman of the examining committee of Mr. Mohanad Shkoor(2005(.
 Chairman of the examining committee of Miss Areej Al-Goul(2002(.
 Chairman of the examining committee of Miss Khawla Ababneh(2002(.
 Member of the examining committee of Mr. N. Abdullah, Jordan Uni .
Science &Technology (2002(.
 Chairman of the examining committee of Mr. I. Muheadat(2001).
 Chairman of the examining Committee of Miss Areej Al_Ghool (2002(.
 Member of the examining committee of Mrs. N. Abu-Naaj (2002(.
 Member of the examining committee of Mrs. M. Saleh (2000(.
 Chairman of the examining committee of Mr. A. Al-Ghazzawi (1999(.
 Member of the examining committee of Mr. M. Al-Omari (1999(.
 Member of the examining committee of Mr. M. Al-Samman (1999).
 Member of the examining committee of Mr. S. Bataineh (1998).
 Member of the examining committee of Mr. S. Al-Majdalawi (1998).
 Member of the examining committee of Mr. Z. Hamadah (1998(.
 Chairman of the examining committee of Miss. E. Ta،¦ani (1998).
 Chairman of the examining committee of Miss. R. Al-Subaihe (1996).
 Member of the examining committee of Mr. L. Al-Momani (1995).
 Member of the examining committee of Mr. K. Abu-Shandi(1995).
 Member of the examining committee of Mr. A. Malkawi (1992).
 Member of the examining committee of Mr. M. Al-Omari (1990).
 Member of the examining committee of Mr. N. Odeh (1990).
 Chairman of the examining committee of Mr. K. Shawaqfeh (1990).
 Member of the examining committee of Mr. M. Smadi (1989).
Grants and Fellowships :
 Abed Al-Hameed Shoman Award for Youth Arab Scientists (1993).
 Alexander Von Hombuldt Research Fellowship-Germany (Sep. 1990 - Aug. 1991; June,
1994 - August, 1992, June 1996, Aug. 1996).
 DAAD Research Fellowship-Germany (summer 1985).
 Several Research Grants from the Deanship of Scientific Research and Graduate Studies
- Yarmouk University (74/84; 16/85; 34/87; 18/88; 2/89; 45/89; 46/89; 31/94; 37/98,
5/2001, 13/2003, 26/2003, 35/2009, 13/2010).
Departmental Committees :
Served as a member of the following departmental committees.
 Advisory Committee.
 Graduate Studies Committee.
 Tender Committee.
 Seminar Committee.
 Library Committee.
 Curriculum and Teaching Plan Committee.
Faculty Committees :
 Faculty of Science Council - Yarmouk University (1994-1995, 2001-2002, 2005-2006,
2006-2007, 2009-2010), serving as a member in the following committees.
a. Curriculum Committee.
b. Orientation Committee.
University Council :
Member of Alzytoonah University Council – 2004 – 2005.
Member of the Yarmouk University Council – 1997 – 1998.
Conferences:
1.
32nd Scientific Week, 1992, Damascus / Syria.
2.
1st International conference of pure and applied chemistry, Yarmouk University, Irbid,
Jordan, 21 - 23 April 1997.
3.
Several seminars dealing with improvement and financing the higher education in
Jordan, held at the Jordan universities in 1997.
4.
38th Scientific Week, 1998, Al-Lathegai. (Teshreen University) / Syria.
5.
2nd International conference of pure and applied chemistry, Yarmouk University,
Irbid, Jordan, 21 - 23 April 2000.
6.
3rd International conference of pure and applied chemistry, Yarmouk University,
Irbid, Jordan, 22 - 26 April 2002.
7.
2nd International conference on chemistry and Applications, Qatar University, Doha,
Qatar, December 6 - 9, 2003.
8.
National Conference in Chemistry 2007, King Soud University- Mecca al-mocarma,
KSA, April, 14 - 15, 2007
9.
International Med. East conf., Istanbul – Turkey, Dec.12-15, 2008.
10.
Taibah international conference in chemistry 2009, Taibah University, Al-madienah
Al-Monawarah, KSA, March, 22-26 , 2009.
11.
Shraja international conf. in chemistry, American Uni. Of Sharja-UAE, March, 1-3,
2011.
12.
Frontiers of chemical research V: Science and education in the Middle East, Paris
France, 4-9 Dec. 2011.
References :
1.
Prof. Dr. Hasan Tashtoush, Chemistry department, Yarmouk University, Irbid, Jordan.
2.
Prof. Dr. Mohammad Mubarak, Department of Chemistry, Jordan University,
Amman, Jordan.
3.
Prof. Dr. Sultan Abu-Orabi, President the Association of the Arab Universities,
Amman, Jordan.
Publications :
1.
Synthesis and structure of heterocumulenes with
units .
C = N = C = O and
C=N=C=S
Mahmoud Al-Talib, I. Jibril, J.C.Jochims and G. Huttner, Chem. Ber. 117, 3211 (1984(.
2.
A new synthesis of 2-Azaallenium salts.
Mahmoud Al-Talib and J.C.Jochims, Chem. Ber. 117, 3222 (1984).
3.
The structure of 2-Azaallium Cations.
Mahmoud Al-Talib, I. Jibril, E.V. Wurthwein, J.C.Jochims and G.Huttner, Chem. Ber.
117 , 3365(1984).
4.
1,1-Diaminosubstituted 2-azaallenium; Preparation and Barriers to Topomerization.
Mahmoud Al-Talib and J.C.Jochims, Tetrahedron, 40, 40109 (1984).
5.
The reaction of Acylium Salts with Carbodiimides.
Mahmoud Al-Talib and J.C.Jochims, Chem. Ber. 118, 1304 (1985(.
6.
The reaction of 2-Azaaallium salts with carbodiimides and tert-butyl Isocyanide.
Mahmoud Al-Talib, I.Jibril, J.C.Jochims and G. Huttner, Tetrahedron, 41, 527 (1985).
7.
Reaction of 1-oxa-3-azabutatrienium salts with Teriary Carboxamides.
Mahmoud Al-Talib, I.Jibril, G. Huttner and J.C.Jochims, Chem. Ber. 118, 1876 (1985(.
8.
2-Azaallenium salts from the reaction of 1-oxa-3-azabutatrienium salts with cyanamides
and carbodiimides.
Mahmoud Al-Talib, J.C.Jochims, L.Zsolnai and G.Huttner, Chem. Ber. 118, 1887(1985).
9.
The reaction of Acylium Salts with Dialkylcyanamides.
Mahmoud Al-Talib and H.Tashtoush, Tetrahedron Lett. 1987, 353.
10.
A convenient synthesis and spectral properties of some new iminium and 2-azaallenium
salts. H. Tashtoush and Mahmoud Al-Talib, J. Chem. and Eng. Data, 32, 477 (1987(.
11.
On the reaction of chlorocarbenium ions with Ammonium Thiocyanate and Potassium
cyanate.
A.Hamed, I. Muller, Mahmoud Al-Talib and J.C.Jochims, Synthesis 1987, 745 .
12.
A convenient synthesis of Amino substituted 1,3,5-oxadiazinium salts.
Mahmoud Al-Talib and H. Tashtoush, J. Heterocyclic Chem. 25, 1023 (1988).
13.
A one pot preparation of substituted bis-1, 3,5-triazinium salts.
Mahmoud Al-Talib, J. Chem. And Eng. Data, 33, 388 (1988).
14.
A convenient synthesis of Amino substituted 2-oxo-1,3,5-triazinium and 1,3,5oxadiazinium salts.
Mahmoud Al-Talib and H. Tashtoush, J. Heterocyclic Chem. 25, 1023 (1988
15.
Lewis acid promoted reactions of 2-Furoyl chloride and 2-thiophene carbonyl chloride with
dialkycyanamides and dialkylcarbodiimides.
Mahmoud Al-Talib and H. Tashtoush, Indian J. Chem. 27B, 934 (1988).
16.
Inhibiting effect of substituted 1,3,5-oxadiazinium salts on the dissolution of copper in
nitric acid.
M. M. Al-Abadallah, Mahmoud Al-Talib and H. Tashtoush, Indian J. of Technology 27,
168 (1989).
17.
A novel one pot synthesis of substituted 1-oxo-1,2,4,6-thiatriazinium salts.
H. Tashtoush and Mahmoud Al-Talib, Recl. Trav. Chem. Payes-Bas, 108, 117 (1989).
18.
Recent advances in the use of acylium salts in organic synthesis.
Mahmoud Al-Talib and H. Tashtoush, Org. Prep. Proc. Int. 22, 1 (1990).
19.
A convenient synthesis of alkyl and arly substituted bis-1,3,4-oxadiazoles.
Mahmoud Al-Talib and H. Tashtoush, and N. Odeh, Synth. Commun 20, 1811 (1990).
20.
Solvolysis of N-chlorosulfinyl diaryl ketimines.
Mahmoud Al-Talib and H. Tashtoush, Leibigs Ann. Chem. 1990, 611.
21.
1
H- and 13C-NMR spectroscopy of N, N،¦-Diacyl acid dihydrazides.
Mahmoud Al-Talib and H. Tashtoush, and N. Odeh, Mag Res. Chem. 28, 1702 (1990).
22.
Acylium Salts: Synthesis of tris-(3,3,5,6-tetrahydro-1,3,5-triazinium) and tris (1,3,5oxadiazinium) salts.
H. Tashtoush and Mahmoud Al-Talib, Recl. Trav. Chem. Pays-Bas 110, 75 (1991).
23.
Reaction of acylium salts with aryl nitriles.
Mahmoud Al-Talib and H. Tashtoush, and M. Al-Omary, J. Parkt. Chemie 333, 303
(1991).
24.
Synthesis and thermal transformation of sustituted bis (1,3,5-triazinium salts).
H. Tashtoush, Mahmoud Al-Talib and K. Shawakfeh, Indian J. Chem. 30B, 491 (1991).
25.
Effect of ethanol and cetonitrile containing some aryl-substituted bis-1,3,5-oxadiazinium
salts on the corrosion of aluminum.
M. M. Abdallah, H. Tashtoush, Mahmoud Al-Talib and M. Al-Omary, Corrosion 47, 449
(1991).
26.
1
H and 13C-NMR spectroscopy of substituted bis-1, 3,4- Oxadiazoles.
H. Tashtoush, Mahmoud Al-Talib and N. Odeh, Magn. Reson. Chem. 30, 910 (1992).
27.
Unusual rearrangement in the dehydration of aroylated butanodihydrazides.
H. Tashtoush, Mahmoud Al-Talib and N. Odeh, Liebigs Ann. Chem. 1992, 291.
28.
3-(4H)-Quinazolines from the reaction of N-arylnitrilium salts with isocyanates
Mahmoud Al-Talib, J. C. Jochims, A. Hamed, Q. Wang, A. Ismial, Synthesis, 1992, 697.
29.
1,2,4-Triazolium salts from the reaction of 1-aza-2-azoniaallene salts with nitriles.
Q. Wang, J. C. Jochims , S. Kohlbrandt, L. Dahlenburg, Mahmoud Al-Talib, A. Hamed ,
A. Ismial, Synthesis, 1992, 710.
30.
On the reaction of N-arylnitrilium salts with acetylenes: synthesis of substituted
Quinolines.
Mahmoud Al-Talib, J. C. Jochims, Q. Wang, A. Hamed, A. Ismial , Synthesis, 1992, 875.
31.
On the reaction of chlorobenzylic cations with isocyanates
A. E. Ismial, A. Hamid, M. Abdel-Aal, I. Zeid, Mahmoud Al-Talib, Q. Wang and J. C.
Jochims, J.Prakt. Chem. 334, 661 (1992).
32.
On the reaction of Dichlorocarbenium ions with isocyanates.
J. C. Jochims , C. Troll, H. Fischer, Q. Wang, A. Hamed, A. E. Ismial, M. Abdel-Aal, I.
Zeid, and Mahmoud Al-Talib, J.Prakt. Chem. 334, 669 (1992).
33.
Synthesis of 4-alkylaminoquinazolenes from the reaction of N-arylnitrilium salts with
dialkylcyanamides.
Mahmoud Al-Talib, J.Prakt. Chem. 335, 584 (1993).
34.
On the reaction of- chlorocarbenium ions with sulfinylamines.`
Q. Wang , Mahmoud Al-Talib and J. C. Jochims , Chem. Ber. 127, 541 (1994).
35.
On the reaction of 1-aza-2-azoniaallena salts with acetylenes.
Q. Wang , Mahmoud Al-Talib and J. C. Jochims , Chem. Ber. 127, 541 (1994).
38.
Synthesis of N-acyliminium salts by reaction of nitrilium salts with ketones.
Mahmoud Al-Talib, M. Zaki, S. Hehl, R. Stumpf. H. Fischer and J. C. Jochims ,
Synthesis, 1996, 1115.
39.
1
H and 13C-NMR spectroscopy of substituted Tris-1,3,4-oxadiazoles.
H. Tashtoush, R. Subaihi and Mahmoud Al-Talib, Magn. Reson. Chem. 35, 549 (1997).
40.
Reaction of nitrilium salts with 6-aminouracil.
A. Hamed and Mahmoud Al-Talib, Org. preps. Proc. Int. 28, 694 (1996).
41.
Facile Synthesis of Unsaturated Lactones via Intramolecular Wittig Reaction
Mahmoud Al-Talib, Magdi Zaki, Sabine Hehl, Rüdiger Stumpf, Helmut Fischer,
Johannes C Jochims
Synthesis, 1996, 2161
42.
Switching selectivity in o-Benzoquinone cycloadditions.
Mahmoud Al-Talib, I.Gerstenberger, P. Jones and Ekkehard Winterfeldt,
Liebigs Ann./ Recueil, 1997, 893.
43.
Unusual rearrangement in reactions of propanodihydrazide and bytanodihydrazide with
carbon disulfide.
Mahmoud Al-Talib and H. Tashtoush, In. J. Chem. 38B, 1374 (1999).
44.
Synthesis and spectroscopic properties of 2-[1-benzyl-1, 2,3-triazolo-4]-5-aryl-1,3,4oxadiazole.
H. Tashtoush, S. T. Abu-Orabi, E. Taan and Mahmoud Al-Talib ,
Asian J. Chem. 11, 441 (1999(.
45.
Synthesis and spectroscopic properties
substituted benzyl-1,2,3-triazoles.
of
4,5-bis-[5-aryl-1,3,4-oxadiazol-2-yl]-1-
H. Tashtoush, S. T. Abu-Orabi, Sh. Al-Majdalawi and Mahmoud Al-Talib, Indian J.
Heterocycl. Chem. 8, 183(1999).
46.
Reaction of 1,3- and 1,4- Bis (1,3,4- oxadiazole ،V 5(3H)-thione ،V2- yl) benzenes with
aryl aldehydes .
Mahmoud Al-Talib, S. Bataineh and H. Tashtoush, Heterocyclic Communications, 5,
429(1999(.
47.
Synthesis of 1,4- and 1,3-Bis ،V(5-alkylthio-1,3,4-oxadiazol-2-yl) Benzenes.
H. Tashtoush, S. Bataineh and Mahmoud Al-Talib, Asian J. Chem. 13, 111 (2001(.
48.
Synthesis, mutagenicity, antibacterial and antifungal activities of bis-1, 3, 4-oxadiazole
derivatives
A. Maslat, M. Abossaud, H. Tashtoush, and Mahmoud Al-Talib, Polish Journal of
Pharmacology, 54, 55, (2002(.
49.
A Notable Antimutagenicity of Two Nonmutagenic Novel Oxadiazoles in Salmonella
Mutagenicity Assay A. Maslat, A. khalil , A. Fares1, H.Tashtoush and
Mahmoud Al-Talib, Drug and Che D Drug and Chemical Toxicology, 27, 157 ( 2004).
50.
Synthesis and spectroscopic properties of substituted Pyrazoles: Novel synthesis of
Pyrazolo[1,2a]pyrazol-4-ylium and Pyrazolo[1,2a]indazol-10-ylium..
Mahmoud Al-Talib, A. Al-ghoul, B. Ziemer, Neubauer and H. Tashtoush ,
Journal of Heterocyclic Chemistry , 42, 287(2005).
Synthesis51.
and Synthesis and evaluation of antimicrobial, cytotoxic, and genotoxic
activities activities of substituted cycloalkanepyrazoles.
H. Tumah; B. Tashtoush; H. Tashtoush; K. Ababneh; Mahmoud Al-Talib,
Acta Pharmaceutica Turcica, 47, 89(2005).
Synthesis52and Synthesis and biological activity of new 5-sulphenyl 4-nitroimidazole derivatives.
H. Tashtoush, Y.Al-Soud, A. Maslat, M. Shkoor, and Mahmoud Al-Talib,
J.J.Chemistry, 2, 245 (2007).
53.
Efficient Synthesis of 2-Aroyl-3-Alkoxy-2,3-Dihydrothiazolo[2,3-c][1,2,4]Triazol-5(6H)ones
Mahmoud Al-Talib, D. Al-Saad, M. Shkoor and H. I. Tashtoush
JJ.Chemisrty, 2009, 4(4), 317-323.
54.
Dual behavior of monothiocarbohydrazones in the cyclization with diethyl acetylene
dicarboxylate "DEAD": synthesis of substituted 1, 3 - thiazolidin-4-ones
Hasan I. Tashtoush, Fatima abusahyon, Mohanad Shkoor and Mahmoud Al-Talib
Journal of sulfur chemistry, 1, 234 (2011).
55.
Synthesis and biological evaluation of new benzothiazoles as antimicrobial agents
Mahmoud Al-Talib, ,Yaseen A. Al-Soud, Mahmud Abussaud, Safaa Khshashneh
Arabian Journal of Chemistry, Available online 17 September 2011.
56.
Synthesis and Characterization of Some Transition Metal Complexes of
Thiocarbohydrazone Schiff Bases. Mahmoud Al-Talib and Fatma Smadi.
Synthesis and Reactivity in Inorganic, Metal-Organic, and NanoMetal Chemistry. Submitted for publication, 2012.
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