9th Indo-Italian Workshop on “Chemistry and Biology of Antioxidants

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9 th Indo-Italian Workshop on

“Chemistry and Biology of Antioxidants: Natural Products based Antioxidants from

Medicinal Plants as Leads towards Development of Novel Drugs” at

Department of Chemistry

University of Delhi

On

10 th -11 th October 2011

To commemorate the year 2011 as the International Year of Chemistry (IYC- 2011)

Organized by

Department of Chemistry,

University of Delhi (DU)

Embassy of Italy, New Delhi

&

Department of Pharmacology

Sapienza University, Rome, Italy

9 th Indo-Italian Workshop on “Chemistry and Biology of Antioxidants: Natural Products based Antioxidants from Medicinal Plants as Leads towards Development of Novel Drugs” during 10th -11th October 2011

ORGANIZATION STRUCTURE

Professor Dinesh K Singh

Vice-Chancellor

University of Delhi

Professor Vivek Suneja

Pro-Vice-Chancellor

University of Delhi

Patrons

HE Giacomo Sanfelice di Monteforte

The Ambassador of Italy in India

Embassy of Italy, New Delhi, India

Professor Dr Lidia Szpyrkowicz

Scientific Attache’

Embassy of Italy, New Delhi

Shri Bala Prasad, IFS

Chief Executive Officer

National Medicinal Plants Board (NMPB, New

Delhi)

Professor Dr Luciano Saso

Department of Pharmacology

Sapienza University of Rome (ITALY)

Dr T Ramasami, FNA

Secretary to the Govt. of India

Department of Science & Technology (DST, New Delhi)

Professor SK Brahamachari, FNA

Director-General

Council of Scientific & Industrial Research (CSIR, New Delhi)

Shri Rajiv Malik

President, Mylon Corporation Inc.

Canonsburg, PA, USA

Presidents

Professor VS Parmar

Department of Chemistry

University of Delhi (INDIA)

Coordinators

Dr Paolo Bovicelli

Italian National Research Council (CNR)

Rome (ITALY)

Professor AK Bakhshi

Head, Department of Chemistry

University of Delhi (INDIA)

Professor SC Batla (DU)

Dr TK Chakraborty, FNA (CDRI, Lucknow)

International Advisory Board

Dr Rajeev Kumar (Unimark Remedies Ltd., Mumbai)

Dr Yatendra Kumar (Wockhardt, Aurangabad)

Professor Monika Datta (DU)

Professor Anthony L DePass (ULI, USA)

Dr Balaram Ghosh, FNA (CSIR-IGIB)

Dr Rajesh Luthra (CSIR)

Professor Udai Maitra, FNA (IISc, Bangalore)

Professor Pavan Mathur (DU)

Dr Shailja Gupta (DBT) Professor Dr Jens Z Pedersen (University Tor Vergata, ITALY)

Professor Dr Rainer Haag (Free Univ., GERMANY) Professor Deepak Pental, FNA (UDSC)

Dr YK Hamied (Cipla Ltd., Mumbai) Dr S Sankaran (DRDO)

Professor Dr Sandra Incerpi (Univ. of Rome, ITALY) Professor Debi Sarkar, FNA (UDSC)

Professor SC Jain (DU) Dr Rajeev Sharma (DST)

Dr VK Kansal (Teva Pharma, Noida)

Dr JM Khanna (Jubilant Organosys, Noida)

Professor JM Khurana (DU)

Professor M Kidwai (DU and Jiwaji University)

Dr BP Singh (DST)

Professor Gurmeet Singh (DU)

Dr OD Tyagi (Unimark Remedies Ltd., Mumbai)

Professor Guiseppe Valacchi ( University of Siena, ITALY)

Professor M Komiyama ( Univ. of Tokyo, JAPAN)

Professor Ajay Kumar (DU)

Chairman

Professor VS Parmar

Department of Chemistry

University of Delhi

Organizing Convener

Dr A Venkateswarlu (Kareus Pharma, Hyderabad)

Professor AC Watterson (UML, USA)

Local Organizing Committee

Secretary

Professor RC Rastogi

Department of Chemistry

University of Delhi

Joint Secretary

Professor Ashok K Prasad

Department of Chemistry

University of Delhi

Dr M Thirumal

Department of Chemistry

University of Delhi

Members

Dr Mahendra Nath (DU)

Dr Raunak (DRDO)

Dr Raju Brahma (DRDO)

Dr Jagdish Chander (DST)

Professor SMS Chauhan (DU)

Dr BS Dawarakanath (DRDO)

Dr GP Garg (AYUSH)

Dr Rajeev Gupta (DU)

Dr Saket Gupta (ONGC)

Professor DS Rawat (DU)

Professor RK Saxena (UDSC)

Dr NA Shakil (IARI)

Professor GL Sharma (CSIR-IGIB)

Professor Rakesh Sharma (DU)

Professor Rama Kant (DU)

Professor JP Khurana, FNA (UDSC)

Professor Shrikant Kukreti (DU)

Dr Padma Kumar (NMPB)

Professor Sunita Malhotra (IGNOU)

Event Planner-cum-Travel Agent

Professor SK Sharma (DU)

Dr BK Singh (DU)

Dr Rajendra Singh (DRDO)

Dr RP Singh (DRDO)

Dr Kavita Tyagi (NMPB)

Financial Consultant-cum-Chartered Accountant

Ms Neelam Kapoor

M/s Namms Tours & Travels

108-109, Gyandeep Complex

66-A, Laxmi Market, Munirka

New Delhi – 110 067 (India)

Email: namms.travel@gmail.com

Ph.: 91-11-26164282, 91-11-26106731

Professor S Sampath

Professor S Sampath & Co.

A-2, Ground Floor

Jangpura Extension

New Delhi – 110 014 (India)

Email: samb602@gmail.com

Ph.:- 24375619, 65385617

Partial list of Speakers alongwith the titles of their talks

Resorcinarene cavitand based antioxidants 1 Professor Kirpal S Bisht

University of South Florida, Tampa, USA

2 Professor AK Chakraborti

NIPER, Mohali, INDIA

3 Professor S Chandrasekaran, FNA

IISc, Bangalore, INDIA

4 Professor VS Chauhan, FNA

ICGEB, New Delhi, INDIA

5 Professor HM Chawla

IIT Delhi, INDIA

6 Dr Ashok Cholli (President & CEO)

Polnox Corporation Inc., Lowell, USA

7 Dr BS Dawarakanath

INMAS, New Delhi, INDIA

8 Dr Balaram Ghosh, FNA

CSIR-IGIB, Delhi, INDIA

9 Professor Concetta Gardi

University of Siena, ITALY

10 Dr Anna Giovanetti

Institute of Radiation Protection ION-IRP, ITALY

11 Professor Dr Rainer Haag

Freie Universitaet Berlin, GERMANY

12 Professor Sandra Incerpi

University Roma Tre, ITALY

13 Dr Ahmed Kamal

IICT, CSIR, Hyderabad, INDIA

14 Professor Vessela Kancheva

Bulgarian Academy of Sciences

Sofia, BULGARIA

15 Professor Jayant Kumar (Director)

CAM, UML, Lowell, USA

Designing novel anti-inflammatory scaffolds

Synthetic studies on organoselenium compounds as antioxidants

Design, synthesis and functional characterization of cationic helical peptides with antimicrobial and antifungal activities

Resorcinarene as a marker for estimation of radical scavenging potential of polyphenols

A new DT-mPM antioxidant technology for improving the stability of bio-based alternate energy fuels and lubricants

Calreticulin as a target for modifying cellular responses to ionizing radiation: Current perspectives

Natural Product-based cinnamate derivatives as novel anti-inflammatory molecules

Oxidative stress in alveolar macrophages from mice with different susceptibility to cigarette smoke

Genetic damage, oxidative stress and protective role of quercetin treatment in irradiated and bystander cells

Multivalent anti-inflammatory drugs: A new multipathway approach

Thyroid hormones and the immune function of THP-1 monocytes: Role of antioxidants

Development of new cancer therapeutics

Comparable kinetic analysis of antiradical and antioxidant activity of new bioantioxidants

16 Dr Kamal Kumar

MPI, Dortmund, GERMANY

17 Professor Christophe Len

UTC, FRANCE

Biocatalytically oligomerized epicatechin exhibiting specific anti-proliferative activity towards human breast cancer cells

Beyond natural products: synthetic rides to solve biology puzzles

Aqueous microwave and subcritical water assisted synthesis of quinolines having anti-microbacterial and cancer radiation therapy activities

Chalcones: Potential therapeutic agents 18 Professor Sanjay Malhotra

Director, Chemical Diversity Division &

Head, Laboratory of Synthetic Chemistry-SAIC,

NCI, NIH, USA

19 Dr Gautam Palit (Senior Deputy Director)

CDRI, CSIR, INDIA

20 Professor Ganesh Pandey, FNA

Head, Organic Division

NCL, CSIR, Pune, INDIA

21 Dr Mukesh Pandey

BWH, Harvard Medical School

Alteration of oxidative system in brain during chronic unpredictable stress in rats

Desymmetrization of meso olefinic C=C bond via chiral ketalization: applications in the total synthesis of some natural products

[ 18 F]Fluoro thia fatty acids as myocardial fatty acid oxidation probes for cardiac and cancer imaging

Harvard University, Boston, USA

22 Professor Jens Z Pedersen

University Tor Vergata, ITALY

23 Professor Paolo Sarti

Sapienza University of Rome, ITALY

24 Dr Nawal K Sharma

Dow Chemical Company, Houston, USA

25 Dr RP Singh

Director Grade Scientist /Scientist 'G'

NCL, CSIR, Pune, INDIA

26 Dr Laura Trapani

University of Rome, ITALY

27 Professor Giuseppe Valacchi

University of Siena, ITALY

28 Professor MA Vijayalakshmi (Director)

CBST; VIT University, INDIA

29 Dr AJ Verma (Deputy Director ‘Scientist G’)

NCL, CSIR, Pune, INDIA

30 Dr JS Yadav, FNA (Director)

IICT, CSIR, Hyderabad, INDIA

Pyocyanin radicals and oxidative stress in cystic fibrosis: Unexpected effects of antioxidants

Nitric oxide controls the respiratory chain electron flux in lymphoid cells: mechanism & pathophysiology

Manipulations in phytoneutraceuticals essential for neuropsychiaric disorders

Natural antioxidants in the stabilization of polymers

Could antioxidants regulate 3-hydroxy 3methylglutaryl coenzyme A reductase and in turn cholesterol homeostasis?

Rottlerin repositioning: From folk medicine to modern prospects in skin diseases (psoriasis)

Antioxidants from some of the traditional Indian plants known for anti diabetic and anti inflammatory activity and protection from DNA cleavage

Chitosan and carbohydrate-linked synthetic polymers as biocompatible polymers for implants

Natural antioxidants

Scientific Scope

1.

Role of free-radicals and oxygen reactive species in human health and diseases

2.

Mechanisms of free-radical promoted diseases

3.

Antioxidants and radical scavengers from natural sources (Medicinal Plants,

Herbs and Species)

4.

Design and synthesis of potential antioxidants and radical scavengers

5.

Study of antioxidants for the development of drugs, in particular against rheumatoid arthritis, COPD, asthma, Aging, Parknison’s, Alzheimer’s, etc.

6.

Antioxidants for modulation of damages caused due to exposure to radiations

7.

Antioxidants in Oil, Natural Gas, Food, Neutraceuticals, Automobile and related industries

8.

Polymeric antioxidants

9.

Role of antioxidants in corrosion and autoxidation

10.

Synergism in the applications of antioxidants

11.

Antioxidants in cancer treatment and radiotherapy

Monday, 10 th October 2011

Registration

(9.00-9.30 hrs)

High Tea

(10.00-10.30 hrs)

Lunch

(13.00-14.00 hrs)

Tea / Snacks

(16.00-16.30 hrs)

SCIENTIFIC PROGRAMME

Dinner

(20.00 hrs)

Inauguration

(9.30-10.00 hrs)

Technical Session I

(10.30-13.00 hrs)

Technical Session II

(14.00-16.00 hrs)

Technical Session III

(16.30-18.00 hrs)

Tuesday, 11 th October 2011

Technical Session IV

Celebrations and commemoration of the

65 th birthday & the Retirement of Professor

HG Raj (VPCI, University of Delhi)

(9.00-11.30 hrs)

Technical Session V

(12.00-13.30 hrs)

Technical Session VI

(14.30-16.00 hrs)

Technical Session VII

(16.30-18.00 hrs)

Tea / Coffee Break

(11.30-12.00 hrs)

Lunch

(13.30-14.30 hrs)

Tea

(16.00-16.30 hrs)

Valediction & High Tea

(18.00-18.30 hrs)

Dinner

(20.30 hrs)

About the Venue

The Department of Chemistry, University of Delhi: The University of Delhi, a Central

University, is a premier institution of India and is known for its high standards in teaching and research. The Department of Chemistry of the University is, perhaps is one of the largest and the oldest Chemistry Departments in the country with 76 faculty positions and nearly 250 research scholars in addition to 500 MSc and MTech students.

In 1963, University Grants Commission recognized the Chemistry Department of

University of Delhi as a Center of Advanced Study for the Chemistry of Natural

Products and later, in 1965, the Department of Chemistry was recognized as a Center of

Advanced Study in Chemistry. The scientific contributions of the Department, in almost all frontier areas of Chemistry, have already made a mark on the international scene.

This Department has so far published over 10,000 research papers in journals of international repute and nearly 2,000 students have received PhD degrees. Several faculty members of the Department are engaged actively in research on isolation, structure elucidation, synthesis and bioactivity evaluation of different classes of natural products from Medicinal Plants, having excellent properties as anti-oxidants and have also developed polymeric antioxidant for applications in different health and industrial sectors.

Accommodation: Participants requiring accommodation may forward their request to the Organizing Convener, latest by 1 st October 2011 for making arrangements on their behalf.

About the Workshop

THE YEAR 2011 HAS BEEN DECLARED AS THE “INTERNATIONAL YEAR OF

CHEMISTRY (IYC-2011) BY THE UNITED NATIONS WITH THE THEME:

CHEMISTRY – OUR LIFE, OUR FUTURE”.

To commemorate this occasion (IYC-2011), the Department of Chemistry (University of

Delhi, India) alongwith the Embassy of Italy, New Delhi and the Department of

Pharmacology, Sapienza University (Rome, Italy) are organizing jointly the 9th Indo-

Italian Workshop on “Chemistry and Biology of Antioxidants: Natural Products based Antioxidants from Medicinal Plants as Leads towards Development of Novel

Drugs” during 10th -11th October 2011 in Delhi.

The participation in the Workshop is limited and shall be by Invitation only.

Background, Scope and Objectives of the Workshop

An active collaboration is undergoing between the Department of Chemistry,

University of Delhi, VP Chest Institute (VPCI, Delhi) & the Institute of Genomics and

Integrative Biology (CSIR-IGIB, Delhi) on the Indian side and the Biomolecular

Chemistry (CNR, Catania, Italy), Sapienza University of Rome and the Institute of

Biomolecular Chemistry (CNR, Rome, Italy) from the Italian Side for nearly ten years.

THE COLLABORATION WAS FUNDED INITIALLY BY THE COUNCIL OF

SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR, INDIA) AND THE ITALIAN

NATIONAL RESEARCH COUNCIL (CNR ROMA, ITALY) AND IS CURRENTLY

BEING FUNDED BY THE INDO-ITALIAN BILATERAL PROJECT ENTITLED

“DEVELOPMENT OF NOVEL ANTIOXIDANT DRUGS” BY THE DEPARTMENT

OF SCIENCE AND TECHNOLOGY (DST, NEW DELHI) & THE NATIONAL

MEDICINAL PLANTS BOARD (NMPB, NEW DELHI) AND THE ITALIAN

MINISTRY OF FOREIGN AFFAIRS AS A PROJECT OF SIGNIFICANCE ON BOTH

THE SIDES. Considering the potential and impact of antioxidant research in daily life, eight Indo-Italian Workshops on “Chemistry and Biology of Antioxidants” have been organized by the University of Delhi (five) and the Sapienza University, Rome (three).

Leading researchers from India and Italy have participated in these meetings and have discussed the collaborative results and the future course of action. Quite a few novel compounds from Edible & Medicinal Plants, spices and herbs, i.e. Trigonella foenum-

graecum (methi, fenugreek), several Piper species [P. nigrum, (black pepper), P. galeatum,

P. betel (pan patta), P. longum (long pepper), P. atematum, P. betuloides, etc.] & several

Prunus species [P. cerasus (cherries), P. domestica (plums), P. cerasoides (wild Himalayan cherry), P. amygdalus (sweet almonds), etc.] have been isolated, some of which and their synthetic analogues showed high activities as anti-platelet, anti-fungal, anti-bacterial & anti-mycobacterial compounds and as anti-inflammatory agents for diseases like COPD, asthma, etc. and are being further studied for development as safer and cheaper drugs.

Several International & Indian patents have been filed (quite a few of which have been approved and granted, some important one’s are listed below).

1.

HG Raj, VS Parmar and P Khurana.

Phenolic acetate drug composition. Patent No. 886/Del/2003, Date of Issue: 6 th

September 2006.

2.

VS Parmar, AK Prasad, HG Raj, M Bose, SK Sharma, R Tandon, A Baghel, A

Kathuria, G Gupta, N Aggarwal.

Coumarin compounds for the treatment of mycobacterial infections.

Application No. 11201-17, Filing Date 5-4-2011.

3.

VS Parmar, HG Raj, AK Prasad and SC Jain.

Coumarin compounds for the treatment of cardiovascular diseases and a process for preparing the same. Application No. 11201-10, Filing Date 23-6-2008; PCT-

11201-10, Filing Date 23-6-2009 & USA 11201-10, Filing Date 23-12-2010.

4.

VS Parmar, HG Raj and AK Prasad.

Dihydropyridimidinone compounds for the treatment of cardiovascular diseases and process for the preparing the same. Application No. 11201-9, Filling Date 13-

6-2008; PCT-11201-9, Filing Date 15-6-2009 & USA 11201-9, Filing Date 2-2-2011.

5.

B Ghosh, VS Parmar, AK Prasad, BK Singh and S Kumar.

Thionated cinnamates and process for preparation thereof.

Application No. 11201-14, Filing Date 21-4-2010.

6.

B Ghosh, VS Parmar, AK Prasad, BK Singh, S Balwani and S Malhotra.

Spiro-(indoline-isoxazolidines) as inhibiters of cytokine-induced cell adhesion molecules. Application No. 11201-12, Filing Date 17-1-2011.

7.

VS Parmar, AK Prasad, B Ghosh, GL Sharma, S Malhotra, S Singh and

S Balwani.

Novel isatin derivatives as effective inhibitors of cell addition molecules.

Application No.: 1591/DEL/2011, Filing Date: 3rd June 2011

A large number of joint publications have been made in International journals of repute as listed below:

1.

MC Foti, SK Sharma, G Shakya, AK Prasad, G Nicolosi, P Bovicelli, B Ghosh, HG

Raj, RC Rastogi and VS Parmar. Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project. Pure and Applied Chemistry 77, 2005, 91-101.

2.

JZ Pederson, C Oliveira, S Incerpi, V Kumar, AM Fiore, P De Vito, AK Prasad, SV

Malhotra, VS Parmar and L Saso. Antioxidant activity of 4-methylcoumarins.

Journal of Pharmacy and Pharmacology 59, 2007, 1721-1728.

3.

S Malhotra, G Shakya,

Ghosh, ME Bracke,

A Kumar, BW Vanhoecke, AL Cholli,

AK Prasad,

HG Raj,

S Biswal and VS Parmar.

L Saso, B

Antioxidant, antiinflammatory and antiinvasive activities of biopolyphenolics. Arkivoc 2008

(vi), 119-139.

4.

S Bansal, M Gaspari, HG Raj, A Kumar, G Cuda, E Veheij, YK Tyagi, P Ponnan,

RC Rastogi and VS Parmar. Calreticulin transacetylase mediates the acetylation of nitric oxide synthase by polyphenolic acetate. Applied Biochemistry and

Biotechnology 144, 2008, 37-45.

5.

S Arora, P Vohra, A Kumar, YK Tyagi, HG Raj, BS Dawarkanath, D Saluja, L Saso and VS Parmar. Calreticulin transacetylase catalyzed activation of rat tracheal smooth muscle cell nitric oxide synthase by acetoxycoumarins. Biological and

Pharmaceutical Bulletin 31, 2008, 709-713.

6.

S Arora, YK Tyagi, A Kumar, S Majumder, D Saluja, HG Raj, S Chatterjee, L Saso,

AK Prasad and VS Parmar. The role of calreticulin transacetylase in the activation of human platelet nitrite reductase by polyphenolic acetates. Biological

and Pharmaceutical Bulletin 32, 2009, 161-165.

7.

S Bansal, P Ponnan, HG Raj, ST Weintraub, M Chopra, R Kumari, D Saluja, A

Kumar, TK Tyagi, P Singh, AK Prasad, L Saso, RC Rastogi and VS Parmar.

Autoacetylation of purified calreticulin transacetylase utilizing acetoxycoumarin as the acetyl group donor. Applied Biochemistry and Biotechnology 152, 2009, 170-

176.

8.

VD Kancheva, L Saso, PV Boranova, A Khan, MK Saroj, MK Pandey, S Malhotra,

JZ Nechev, SK Sharma, AK Prasad, MB Georgieva, C Joseph, AL DePass, RC

Rastogi and VS Parmar. Structure-activity relationship of dihydroxy-4methylcoumarins as powerful antioxidants: Correlation between experimental & theoretical data and synergistic effect. Biochimie 92, 2010, 1089-1100.

9.

M Giuseppa, T Domenico, BK Singh, AK Prasad, VS Parmar, N Clara, M

Ferdinando, S Antonina, C Mariateresa, F Omidreza and L Saso. Antioxidant properties of 4-methylcoumarins in in vitro cell-free systems. Biochimie 92, 2010,

1101-1107.

10.

P Mladenka, K Macakova, L Zatloukalova, Z Rehakova, BK Singh, AK Prasad,

VS Parmar, L Jahodar, R Hrdina and L Saso. In vitro interactions of coumarins with iron. Biochimie 92, 2010, 1108-1114.

11.

R Petrucci, L Saso, V Kumar, AK Prasad, SV Malhotra, VS Parmar and G

Marrosu. A spectroelectrochemical and chemical study on oxidation of 7,8dihydroxy-4-methylcoumarin (DHMC) and some related compounds in aprotic medium. Biochimie 92, 2010, 1123-1129.

12.

F Natella, B Lorrain, AK Prasad, VS Parmar, L Saso and C Scaccini. 4-

Methylcoumarins as antioxidants: Scavenging of peroxyl radicals and inhibition of human low-density lipoprotein oxidation. Biochimie 92, 2010, 1147-1152.

13.

P Gupta, S Balwani, S Kumar, N Aggarwal, M Rossi, S Paumier, F Caruso, P

Bovicelli, L Saso, AL DePass, AK Prasad, VS Parmar and B Ghosh. β-Sitosterol among other secondary metabolites of Piper galeatum shows inhibition of TNFαinduced cell adhesion molecule expression on human endothelial cells. Biochimie

92, 2010, 1213-1221.

14.

P Singh, P Ponnan, S Krishnan, TK Tyagi, N Priya, S Bansal, D Scumaci, M

Gaspari, G Cuda, P Joshi, JK Gambhir, D Saluja, AK Prasad, L Saso, RC Rastogi,

VS Parmar and HG Raj. Protein acyltransferase function of purified clareticulin.

Part 1: characterization of propionylation of protein utilizing propoxycoumarin as the propionyl group donor. The Journal of Biochemistry 147, 2010, 625-632.

15.

R Kumari, S Bansal, G Gupta, S Arora, A Kumar, S Goel, P Singh, P Ponnan, N

Priya, TK Tyagi, AS Baghel, S Manral, R Tandon, R Joshi, V Rohil, M Gaspari, E

Kohli, YK Tyagi, BS Dwarkanath, D Saluja, S Chatterji, SK Sharma, AK Prasad,

RC Rastogi, HG Raj and VS Parmar. Calreticulin transacylase: Genesis, mechanism of action and biological applications. Biochimie 92, 2010, 1173-1179.

16.

P Singh, P Ponnan, N Priya, TK Tyagi, S Krishnan, M Gaspari, G Cuda, P Joshi,

JK Gambhir, D Saluja, AK Prasad, L Saso, RC Rastogi, VS Parmar and HG Raj.

Protein acyltransferase function of purified calreticulin: The exclusive role of Pdomain in mediating protein acylation utilizing acyloxycoumarins and acetyl

CoA as the acyl group donors. Protein and Peptide Letters, 18, 2011, 507-517.

17.

L Trapani, M Segatto, V Simeoni, V Balducci, A Dhawan, VS Parmar, AK Prasad,

L Saso, S Incerpi, V Pallottini. Short- and long-term regulation of 3-hydroxy 3methylglutaryl coenzyme A reductase by a 4-methylcoumarin. Biochimie 93, 2011,

1165-1171.

18.

S Manral, S Bhatia, R Sinha, A Kumar, V Rohil, A Arya, A Dhawan, P Arya, R

Joshi, SC Sreedhara, S Gangopadhyay, SK Bansal, S Chatterjee, NK Chaudhury,

VK Vijayan, L Saso, VS Parmar, AL DePass, AK Prasad, HG Raj. Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM. Biochimie, 93, 2011, 1146-1156.

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