9 th Indo-Italian Workshop on
“Chemistry and Biology of Antioxidants: Natural Products based Antioxidants from
Medicinal Plants as Leads towards Development of Novel Drugs” at
Department of Chemistry
University of Delhi
On
10 th -11 th October 2011
To commemorate the year 2011 as the International Year of Chemistry (IYC- 2011)
Organized by
Department of Chemistry,
University of Delhi (DU)
Embassy of Italy, New Delhi
&
Department of Pharmacology
Sapienza University, Rome, Italy
9 th Indo-Italian Workshop on “Chemistry and Biology of Antioxidants: Natural Products based Antioxidants from Medicinal Plants as Leads towards Development of Novel Drugs” during 10th -11th October 2011
ORGANIZATION STRUCTURE
Professor Dinesh K Singh
Vice-Chancellor
University of Delhi
Professor Vivek Suneja
Pro-Vice-Chancellor
University of Delhi
Patrons
HE Giacomo Sanfelice di Monteforte
The Ambassador of Italy in India
Embassy of Italy, New Delhi, India
Professor Dr Lidia Szpyrkowicz
Scientific Attache’
Embassy of Italy, New Delhi
Shri Bala Prasad, IFS
Chief Executive Officer
National Medicinal Plants Board (NMPB, New
Delhi)
Professor Dr Luciano Saso
Department of Pharmacology
Sapienza University of Rome (ITALY)
Dr T Ramasami, FNA
Secretary to the Govt. of India
Department of Science & Technology (DST, New Delhi)
Professor SK Brahamachari, FNA
Director-General
Council of Scientific & Industrial Research (CSIR, New Delhi)
Shri Rajiv Malik
President, Mylon Corporation Inc.
Canonsburg, PA, USA
Presidents
Professor VS Parmar
Department of Chemistry
University of Delhi (INDIA)
Coordinators
Dr Paolo Bovicelli
Italian National Research Council (CNR)
Rome (ITALY)
Professor AK Bakhshi
Head, Department of Chemistry
University of Delhi (INDIA)
Professor SC Batla (DU)
Dr TK Chakraborty, FNA (CDRI, Lucknow)
International Advisory Board
Dr Rajeev Kumar (Unimark Remedies Ltd., Mumbai)
Dr Yatendra Kumar (Wockhardt, Aurangabad)
Professor Monika Datta (DU)
Professor Anthony L DePass (ULI, USA)
Dr Balaram Ghosh, FNA (CSIR-IGIB)
Dr Rajesh Luthra (CSIR)
Professor Udai Maitra, FNA (IISc, Bangalore)
Professor Pavan Mathur (DU)
Dr Shailja Gupta (DBT) Professor Dr Jens Z Pedersen (University Tor Vergata, ITALY)
Professor Dr Rainer Haag (Free Univ., GERMANY) Professor Deepak Pental, FNA (UDSC)
Dr YK Hamied (Cipla Ltd., Mumbai) Dr S Sankaran (DRDO)
Professor Dr Sandra Incerpi (Univ. of Rome, ITALY) Professor Debi Sarkar, FNA (UDSC)
Professor SC Jain (DU) Dr Rajeev Sharma (DST)
Dr VK Kansal (Teva Pharma, Noida)
Dr JM Khanna (Jubilant Organosys, Noida)
Professor JM Khurana (DU)
Professor M Kidwai (DU and Jiwaji University)
Dr BP Singh (DST)
Professor Gurmeet Singh (DU)
Dr OD Tyagi (Unimark Remedies Ltd., Mumbai)
Professor Guiseppe Valacchi ( University of Siena, ITALY)
Professor M Komiyama ( Univ. of Tokyo, JAPAN)
Professor Ajay Kumar (DU)
Chairman
Professor VS Parmar
Department of Chemistry
University of Delhi
Organizing Convener
Dr A Venkateswarlu (Kareus Pharma, Hyderabad)
Professor AC Watterson (UML, USA)
Local Organizing Committee
Secretary
Professor RC Rastogi
Department of Chemistry
University of Delhi
Joint Secretary
Professor Ashok K Prasad
Department of Chemistry
University of Delhi
Dr M Thirumal
Department of Chemistry
University of Delhi
Members
Dr Mahendra Nath (DU)
Dr Raunak (DRDO)
Dr Raju Brahma (DRDO)
Dr Jagdish Chander (DST)
Professor SMS Chauhan (DU)
Dr BS Dawarakanath (DRDO)
Dr GP Garg (AYUSH)
Dr Rajeev Gupta (DU)
Dr Saket Gupta (ONGC)
Professor DS Rawat (DU)
Professor RK Saxena (UDSC)
Dr NA Shakil (IARI)
Professor GL Sharma (CSIR-IGIB)
Professor Rakesh Sharma (DU)
Professor Rama Kant (DU)
Professor JP Khurana, FNA (UDSC)
Professor Shrikant Kukreti (DU)
Dr Padma Kumar (NMPB)
Professor Sunita Malhotra (IGNOU)
Event Planner-cum-Travel Agent
Professor SK Sharma (DU)
Dr BK Singh (DU)
Dr Rajendra Singh (DRDO)
Dr RP Singh (DRDO)
Dr Kavita Tyagi (NMPB)
Financial Consultant-cum-Chartered Accountant
Ms Neelam Kapoor
M/s Namms Tours & Travels
108-109, Gyandeep Complex
66-A, Laxmi Market, Munirka
New Delhi – 110 067 (India)
Email: namms.travel@gmail.com
Ph.: 91-11-26164282, 91-11-26106731
Professor S Sampath
Professor S Sampath & Co.
A-2, Ground Floor
Jangpura Extension
New Delhi – 110 014 (India)
Email: samb602@gmail.com
Ph.:- 24375619, 65385617
Partial list of Speakers alongwith the titles of their talks
Resorcinarene cavitand based antioxidants 1 Professor Kirpal S Bisht
University of South Florida, Tampa, USA
2 Professor AK Chakraborti
NIPER, Mohali, INDIA
3 Professor S Chandrasekaran, FNA
IISc, Bangalore, INDIA
4 Professor VS Chauhan, FNA
ICGEB, New Delhi, INDIA
5 Professor HM Chawla
IIT Delhi, INDIA
6 Dr Ashok Cholli (President & CEO)
Polnox Corporation Inc., Lowell, USA
7 Dr BS Dawarakanath
INMAS, New Delhi, INDIA
8 Dr Balaram Ghosh, FNA
CSIR-IGIB, Delhi, INDIA
9 Professor Concetta Gardi
University of Siena, ITALY
10 Dr Anna Giovanetti
Institute of Radiation Protection ION-IRP, ITALY
11 Professor Dr Rainer Haag
Freie Universitaet Berlin, GERMANY
12 Professor Sandra Incerpi
University Roma Tre, ITALY
13 Dr Ahmed Kamal
IICT, CSIR, Hyderabad, INDIA
14 Professor Vessela Kancheva
Bulgarian Academy of Sciences
Sofia, BULGARIA
15 Professor Jayant Kumar (Director)
CAM, UML, Lowell, USA
Designing novel anti-inflammatory scaffolds
Synthetic studies on organoselenium compounds as antioxidants
Design, synthesis and functional characterization of cationic helical peptides with antimicrobial and antifungal activities
Resorcinarene as a marker for estimation of radical scavenging potential of polyphenols
A new DT-mPM antioxidant technology for improving the stability of bio-based alternate energy fuels and lubricants
Calreticulin as a target for modifying cellular responses to ionizing radiation: Current perspectives
Natural Product-based cinnamate derivatives as novel anti-inflammatory molecules
Oxidative stress in alveolar macrophages from mice with different susceptibility to cigarette smoke
Genetic damage, oxidative stress and protective role of quercetin treatment in irradiated and bystander cells
Multivalent anti-inflammatory drugs: A new multipathway approach
Thyroid hormones and the immune function of THP-1 monocytes: Role of antioxidants
Development of new cancer therapeutics
Comparable kinetic analysis of antiradical and antioxidant activity of new bioantioxidants
16 Dr Kamal Kumar
MPI, Dortmund, GERMANY
17 Professor Christophe Len
UTC, FRANCE
Biocatalytically oligomerized epicatechin exhibiting specific anti-proliferative activity towards human breast cancer cells
Beyond natural products: synthetic rides to solve biology puzzles
Aqueous microwave and subcritical water assisted synthesis of quinolines having anti-microbacterial and cancer radiation therapy activities
Chalcones: Potential therapeutic agents 18 Professor Sanjay Malhotra
Director, Chemical Diversity Division &
Head, Laboratory of Synthetic Chemistry-SAIC,
NCI, NIH, USA
19 Dr Gautam Palit (Senior Deputy Director)
CDRI, CSIR, INDIA
20 Professor Ganesh Pandey, FNA
Head, Organic Division
NCL, CSIR, Pune, INDIA
21 Dr Mukesh Pandey
BWH, Harvard Medical School
Alteration of oxidative system in brain during chronic unpredictable stress in rats
Desymmetrization of meso olefinic C=C bond via chiral ketalization: applications in the total synthesis of some natural products
[ 18 F]Fluoro thia fatty acids as myocardial fatty acid oxidation probes for cardiac and cancer imaging
Harvard University, Boston, USA
22 Professor Jens Z Pedersen
University Tor Vergata, ITALY
23 Professor Paolo Sarti
Sapienza University of Rome, ITALY
24 Dr Nawal K Sharma
Dow Chemical Company, Houston, USA
25 Dr RP Singh
Director Grade Scientist /Scientist 'G'
NCL, CSIR, Pune, INDIA
26 Dr Laura Trapani
University of Rome, ITALY
27 Professor Giuseppe Valacchi
University of Siena, ITALY
28 Professor MA Vijayalakshmi (Director)
CBST; VIT University, INDIA
29 Dr AJ Verma (Deputy Director ‘Scientist G’)
NCL, CSIR, Pune, INDIA
30 Dr JS Yadav, FNA (Director)
IICT, CSIR, Hyderabad, INDIA
Pyocyanin radicals and oxidative stress in cystic fibrosis: Unexpected effects of antioxidants
Nitric oxide controls the respiratory chain electron flux in lymphoid cells: mechanism & pathophysiology
Manipulations in phytoneutraceuticals essential for neuropsychiaric disorders
Natural antioxidants in the stabilization of polymers
Could antioxidants regulate 3-hydroxy 3methylglutaryl coenzyme A reductase and in turn cholesterol homeostasis?
Rottlerin repositioning: From folk medicine to modern prospects in skin diseases (psoriasis)
Antioxidants from some of the traditional Indian plants known for anti diabetic and anti inflammatory activity and protection from DNA cleavage
Chitosan and carbohydrate-linked synthetic polymers as biocompatible polymers for implants
Natural antioxidants
Scientific Scope
1.
Role of free-radicals and oxygen reactive species in human health and diseases
2.
Mechanisms of free-radical promoted diseases
3.
Antioxidants and radical scavengers from natural sources (Medicinal Plants,
Herbs and Species)
4.
Design and synthesis of potential antioxidants and radical scavengers
5.
Study of antioxidants for the development of drugs, in particular against rheumatoid arthritis, COPD, asthma, Aging, Parknison’s, Alzheimer’s, etc.
6.
Antioxidants for modulation of damages caused due to exposure to radiations
7.
Antioxidants in Oil, Natural Gas, Food, Neutraceuticals, Automobile and related industries
8.
Polymeric antioxidants
9.
Role of antioxidants in corrosion and autoxidation
10.
Synergism in the applications of antioxidants
11.
Antioxidants in cancer treatment and radiotherapy
Monday, 10 th October 2011
Registration
(9.00-9.30 hrs)
High Tea
(10.00-10.30 hrs)
Lunch
(13.00-14.00 hrs)
Tea / Snacks
(16.00-16.30 hrs)
SCIENTIFIC PROGRAMME
Dinner
(20.00 hrs)
Inauguration
(9.30-10.00 hrs)
Technical Session I
(10.30-13.00 hrs)
Technical Session II
(14.00-16.00 hrs)
Technical Session III
(16.30-18.00 hrs)
Tuesday, 11 th October 2011
Technical Session IV
Celebrations and commemoration of the
65 th birthday & the Retirement of Professor
HG Raj (VPCI, University of Delhi)
(9.00-11.30 hrs)
Technical Session V
(12.00-13.30 hrs)
Technical Session VI
(14.30-16.00 hrs)
Technical Session VII
(16.30-18.00 hrs)
Tea / Coffee Break
(11.30-12.00 hrs)
Lunch
(13.30-14.30 hrs)
Tea
(16.00-16.30 hrs)
Valediction & High Tea
(18.00-18.30 hrs)
Dinner
(20.30 hrs)
The Department of Chemistry, University of Delhi: The University of Delhi, a Central
University, is a premier institution of India and is known for its high standards in teaching and research. The Department of Chemistry of the University is, perhaps is one of the largest and the oldest Chemistry Departments in the country with 76 faculty positions and nearly 250 research scholars in addition to 500 MSc and MTech students.
In 1963, University Grants Commission recognized the Chemistry Department of
University of Delhi as a Center of Advanced Study for the Chemistry of Natural
Products and later, in 1965, the Department of Chemistry was recognized as a Center of
Advanced Study in Chemistry. The scientific contributions of the Department, in almost all frontier areas of Chemistry, have already made a mark on the international scene.
This Department has so far published over 10,000 research papers in journals of international repute and nearly 2,000 students have received PhD degrees. Several faculty members of the Department are engaged actively in research on isolation, structure elucidation, synthesis and bioactivity evaluation of different classes of natural products from Medicinal Plants, having excellent properties as anti-oxidants and have also developed polymeric antioxidant for applications in different health and industrial sectors.
Accommodation: Participants requiring accommodation may forward their request to the Organizing Convener, latest by 1 st October 2011 for making arrangements on their behalf.
About the Workshop
THE YEAR 2011 HAS BEEN DECLARED AS THE “INTERNATIONAL YEAR OF
CHEMISTRY (IYC-2011) BY THE UNITED NATIONS WITH THE THEME:
CHEMISTRY – OUR LIFE, OUR FUTURE”.
To commemorate this occasion (IYC-2011), the Department of Chemistry (University of
Delhi, India) alongwith the Embassy of Italy, New Delhi and the Department of
Pharmacology, Sapienza University (Rome, Italy) are organizing jointly the 9th Indo-
Italian Workshop on “Chemistry and Biology of Antioxidants: Natural Products based Antioxidants from Medicinal Plants as Leads towards Development of Novel
Drugs” during 10th -11th October 2011 in Delhi.
The participation in the Workshop is limited and shall be by Invitation only.
Background, Scope and Objectives of the Workshop
An active collaboration is undergoing between the Department of Chemistry,
University of Delhi, VP Chest Institute (VPCI, Delhi) & the Institute of Genomics and
Integrative Biology (CSIR-IGIB, Delhi) on the Indian side and the Biomolecular
Chemistry (CNR, Catania, Italy), Sapienza University of Rome and the Institute of
Biomolecular Chemistry (CNR, Rome, Italy) from the Italian Side for nearly ten years.
THE COLLABORATION WAS FUNDED INITIALLY BY THE COUNCIL OF
SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR, INDIA) AND THE ITALIAN
NATIONAL RESEARCH COUNCIL (CNR ROMA, ITALY) AND IS CURRENTLY
BEING FUNDED BY THE INDO-ITALIAN BILATERAL PROJECT ENTITLED
“DEVELOPMENT OF NOVEL ANTIOXIDANT DRUGS” BY THE DEPARTMENT
OF SCIENCE AND TECHNOLOGY (DST, NEW DELHI) & THE NATIONAL
MEDICINAL PLANTS BOARD (NMPB, NEW DELHI) AND THE ITALIAN
MINISTRY OF FOREIGN AFFAIRS AS A PROJECT OF SIGNIFICANCE ON BOTH
THE SIDES. Considering the potential and impact of antioxidant research in daily life, eight Indo-Italian Workshops on “Chemistry and Biology of Antioxidants” have been organized by the University of Delhi (five) and the Sapienza University, Rome (three).
Leading researchers from India and Italy have participated in these meetings and have discussed the collaborative results and the future course of action. Quite a few novel compounds from Edible & Medicinal Plants, spices and herbs, i.e. Trigonella foenum-
graecum (methi, fenugreek), several Piper species [P. nigrum, (black pepper), P. galeatum,
P. betel (pan patta), P. longum (long pepper), P. atematum, P. betuloides, etc.] & several
Prunus species [P. cerasus (cherries), P. domestica (plums), P. cerasoides (wild Himalayan cherry), P. amygdalus (sweet almonds), etc.] have been isolated, some of which and their synthetic analogues showed high activities as anti-platelet, anti-fungal, anti-bacterial & anti-mycobacterial compounds and as anti-inflammatory agents for diseases like COPD, asthma, etc. and are being further studied for development as safer and cheaper drugs.
Several International & Indian patents have been filed (quite a few of which have been approved and granted, some important one’s are listed below).
1.
HG Raj, VS Parmar and P Khurana.
Phenolic acetate drug composition. Patent No. 886/Del/2003, Date of Issue: 6 th
September 2006.
2.
VS Parmar, AK Prasad, HG Raj, M Bose, SK Sharma, R Tandon, A Baghel, A
Kathuria, G Gupta, N Aggarwal.
Coumarin compounds for the treatment of mycobacterial infections.
Application No. 11201-17, Filing Date 5-4-2011.
3.
VS Parmar, HG Raj, AK Prasad and SC Jain.
Coumarin compounds for the treatment of cardiovascular diseases and a process for preparing the same. Application No. 11201-10, Filing Date 23-6-2008; PCT-
11201-10, Filing Date 23-6-2009 & USA 11201-10, Filing Date 23-12-2010.
4.
VS Parmar, HG Raj and AK Prasad.
Dihydropyridimidinone compounds for the treatment of cardiovascular diseases and process for the preparing the same. Application No. 11201-9, Filling Date 13-
6-2008; PCT-11201-9, Filing Date 15-6-2009 & USA 11201-9, Filing Date 2-2-2011.
5.
B Ghosh, VS Parmar, AK Prasad, BK Singh and S Kumar.
Thionated cinnamates and process for preparation thereof.
Application No. 11201-14, Filing Date 21-4-2010.
6.
B Ghosh, VS Parmar, AK Prasad, BK Singh, S Balwani and S Malhotra.
Spiro-(indoline-isoxazolidines) as inhibiters of cytokine-induced cell adhesion molecules. Application No. 11201-12, Filing Date 17-1-2011.
7.
VS Parmar, AK Prasad, B Ghosh, GL Sharma, S Malhotra, S Singh and
S Balwani.
Novel isatin derivatives as effective inhibitors of cell addition molecules.
Application No.: 1591/DEL/2011, Filing Date: 3rd June 2011
A large number of joint publications have been made in International journals of repute as listed below:
1.
MC Foti, SK Sharma, G Shakya, AK Prasad, G Nicolosi, P Bovicelli, B Ghosh, HG
Raj, RC Rastogi and VS Parmar. Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project. Pure and Applied Chemistry 77, 2005, 91-101.
2.
JZ Pederson, C Oliveira, S Incerpi, V Kumar, AM Fiore, P De Vito, AK Prasad, SV
Malhotra, VS Parmar and L Saso. Antioxidant activity of 4-methylcoumarins.
Journal of Pharmacy and Pharmacology 59, 2007, 1721-1728.
3.
S Malhotra, G Shakya,
Ghosh, ME Bracke,
A Kumar, BW Vanhoecke, AL Cholli,
AK Prasad,
HG Raj,
S Biswal and VS Parmar.
L Saso, B
Antioxidant, antiinflammatory and antiinvasive activities of biopolyphenolics. Arkivoc 2008
(vi), 119-139.
4.
S Bansal, M Gaspari, HG Raj, A Kumar, G Cuda, E Veheij, YK Tyagi, P Ponnan,
RC Rastogi and VS Parmar. Calreticulin transacetylase mediates the acetylation of nitric oxide synthase by polyphenolic acetate. Applied Biochemistry and
Biotechnology 144, 2008, 37-45.
5.
S Arora, P Vohra, A Kumar, YK Tyagi, HG Raj, BS Dawarkanath, D Saluja, L Saso and VS Parmar. Calreticulin transacetylase catalyzed activation of rat tracheal smooth muscle cell nitric oxide synthase by acetoxycoumarins. Biological and
Pharmaceutical Bulletin 31, 2008, 709-713.
6.
S Arora, YK Tyagi, A Kumar, S Majumder, D Saluja, HG Raj, S Chatterjee, L Saso,
AK Prasad and VS Parmar. The role of calreticulin transacetylase in the activation of human platelet nitrite reductase by polyphenolic acetates. Biological
and Pharmaceutical Bulletin 32, 2009, 161-165.
7.
S Bansal, P Ponnan, HG Raj, ST Weintraub, M Chopra, R Kumari, D Saluja, A
Kumar, TK Tyagi, P Singh, AK Prasad, L Saso, RC Rastogi and VS Parmar.
Autoacetylation of purified calreticulin transacetylase utilizing acetoxycoumarin as the acetyl group donor. Applied Biochemistry and Biotechnology 152, 2009, 170-
176.
8.
VD Kancheva, L Saso, PV Boranova, A Khan, MK Saroj, MK Pandey, S Malhotra,
JZ Nechev, SK Sharma, AK Prasad, MB Georgieva, C Joseph, AL DePass, RC
Rastogi and VS Parmar. Structure-activity relationship of dihydroxy-4methylcoumarins as powerful antioxidants: Correlation between experimental & theoretical data and synergistic effect. Biochimie 92, 2010, 1089-1100.
9.
M Giuseppa, T Domenico, BK Singh, AK Prasad, VS Parmar, N Clara, M
Ferdinando, S Antonina, C Mariateresa, F Omidreza and L Saso. Antioxidant properties of 4-methylcoumarins in in vitro cell-free systems. Biochimie 92, 2010,
1101-1107.
10.
P Mladenka, K Macakova, L Zatloukalova, Z Rehakova, BK Singh, AK Prasad,
VS Parmar, L Jahodar, R Hrdina and L Saso. In vitro interactions of coumarins with iron. Biochimie 92, 2010, 1108-1114.
11.
R Petrucci, L Saso, V Kumar, AK Prasad, SV Malhotra, VS Parmar and G
Marrosu. A spectroelectrochemical and chemical study on oxidation of 7,8dihydroxy-4-methylcoumarin (DHMC) and some related compounds in aprotic medium. Biochimie 92, 2010, 1123-1129.
12.
F Natella, B Lorrain, AK Prasad, VS Parmar, L Saso and C Scaccini. 4-
Methylcoumarins as antioxidants: Scavenging of peroxyl radicals and inhibition of human low-density lipoprotein oxidation. Biochimie 92, 2010, 1147-1152.
13.
P Gupta, S Balwani, S Kumar, N Aggarwal, M Rossi, S Paumier, F Caruso, P
Bovicelli, L Saso, AL DePass, AK Prasad, VS Parmar and B Ghosh. β-Sitosterol among other secondary metabolites of Piper galeatum shows inhibition of TNFαinduced cell adhesion molecule expression on human endothelial cells. Biochimie
92, 2010, 1213-1221.
14.
P Singh, P Ponnan, S Krishnan, TK Tyagi, N Priya, S Bansal, D Scumaci, M
Gaspari, G Cuda, P Joshi, JK Gambhir, D Saluja, AK Prasad, L Saso, RC Rastogi,
VS Parmar and HG Raj. Protein acyltransferase function of purified clareticulin.
Part 1: characterization of propionylation of protein utilizing propoxycoumarin as the propionyl group donor. The Journal of Biochemistry 147, 2010, 625-632.
15.
R Kumari, S Bansal, G Gupta, S Arora, A Kumar, S Goel, P Singh, P Ponnan, N
Priya, TK Tyagi, AS Baghel, S Manral, R Tandon, R Joshi, V Rohil, M Gaspari, E
Kohli, YK Tyagi, BS Dwarkanath, D Saluja, S Chatterji, SK Sharma, AK Prasad,
RC Rastogi, HG Raj and VS Parmar. Calreticulin transacylase: Genesis, mechanism of action and biological applications. Biochimie 92, 2010, 1173-1179.
16.
P Singh, P Ponnan, N Priya, TK Tyagi, S Krishnan, M Gaspari, G Cuda, P Joshi,
JK Gambhir, D Saluja, AK Prasad, L Saso, RC Rastogi, VS Parmar and HG Raj.
Protein acyltransferase function of purified calreticulin: The exclusive role of Pdomain in mediating protein acylation utilizing acyloxycoumarins and acetyl
CoA as the acyl group donors. Protein and Peptide Letters, 18, 2011, 507-517.
17.
L Trapani, M Segatto, V Simeoni, V Balducci, A Dhawan, VS Parmar, AK Prasad,
L Saso, S Incerpi, V Pallottini. Short- and long-term regulation of 3-hydroxy 3methylglutaryl coenzyme A reductase by a 4-methylcoumarin. Biochimie 93, 2011,
1165-1171.
18.
S Manral, S Bhatia, R Sinha, A Kumar, V Rohil, A Arya, A Dhawan, P Arya, R
Joshi, SC Sreedhara, S Gangopadhyay, SK Bansal, S Chatterjee, NK Chaudhury,
VK Vijayan, L Saso, VS Parmar, AL DePass, AK Prasad, HG Raj. Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM. Biochimie, 93, 2011, 1146-1156.