Lectures in Human Physiology BIOS 464/564
Fall 2005
8:00-8:50am
M,T,W,F
PLSCI 114
Instructors
Curt Anderson, Ph.D.
Office: LS 331
Office Hours: 10-11am M,W or by appt.
Phone: 282-5813
e-mail: andecurt@isu.edu
http://www.isu.edu/~andecurt
Ken Rodnick, Ph.D.
Office: LS 327
Office Hours: 4-6 pm Wed. or by appt.
Phone: 282-3790
e-mail: rodnkenn@isu.edu
Course Description
Physiology is the study of functions and mechanisms of living organisms. Human
Physiology is a course that addresses the processes and mechanisms that are characteristic of
human life with an emphasis on several important systems and how these systems interact with
each other for maintenance of homeostasis of the organism as a whole. The objectives of this
course are to provide students with fundamental concepts of how normal systems work, upon which
an understanding of consequences in disease states can be built.
Because students in this course have had a previous course(s) in human or mammalian
physiology, material will be covered in greater depth. The material will be presented under several
major topic areas: general physiology and biological molecules, muscle, endocrine, gastrointestinal,
cardiovascular, respiratory, renal and neuro-physiology. These units will be integrated as the
course progresses. The study of intrinsic and extrinsic control systems and how they help maintain
homeostasis is of prime importance in physiology. An attempt will be made to emphasize
understanding the fundamental processes and on problem solving rather than on memorization and
recalling excessive amounts of ‘facts’. However, we will be building upon your physiology
‘vocabulary’ throughout the course as your working knowledge of physiology improves.
Objectives
Detailed objectives will be provided prior to each module, however, in general your goals
should be:
1.1 Demonstrate a positive attitude toward learning. Attend didactic lectures and laboratory
exercises, and actively participate in open discussions. Approach laboratory activities with a
degree of enthusiasm and curiosity.
1.2 Recognize learning objectives as well as responsibilities of the instructor and students.
Learning objectives will be provided at the beginning of each topic. The goal and responsibility of
the instructor is to facilitate learning and development of problem-solving ability in students. The
student, in turn, should not simply be a passive recipient of information. The success of this course
depends on effective communication between students and instructor in the classroom.
1.3 Acquire factual knowledge and develop an understanding of physiological concepts and
principles. Complete textbook readings and complimentary outside assignments. Student are
also expected to develop a wider scope of understanding than can be provided in lecture and
laboratory.
1.4 Demonstrate the ability to identify and complete physiology problems, including data
analysis and presentation. Perform at an appropriate level (80% or higher) on written
examinations and oral presentations. Examinations will strike a balance between fact recall, logical
explanation, and synthetic analysis. Evaluation is based on a traditional format (e.g., multiple
choice and fill-in-the blank), short essays, and problems that integrate several sources of
information.
1.5 Identification of need for further information and location of resources. Students will
familiarize themselves with additional resources for medical physiology as it pertains to the PA
program. Examples include scientific journals, on-line medical databases, library searches, and
Science Citation Index. Students should develop a strong appreciation for seeking clarification in
our understanding of physiology as it pertains to clinical medicine and therapy.
2.0
Major physiological systems, including components to be covered:
2.1 Cellular physiology
Membrane functions, diffusion, osmosis, and transport processes
2.2 Nervous system
Neurotransmitters and receptors
Action potential conduction
Synaptic transmission
Motor function (spinal cord, brain stem, cerebellum and basal ganglia)
Autonomic (sympathetic and parasympathetic systems)
Somatic sensations (tactile, position, pain, and temperature)
Introduction to neuropathology
2.3 Skeletal muscle
Mechanism of contraction
Muscle spindle
Golgi tendon organ
Strength, endurance, and fatigue
2.4 Cardiovascular system
Cardiac and smooth muscle
Characteristics of cardiac contractility
The heart as a mechanical pump
The “Cardiac Cycle”
Basic electrocardiography
Circulatory function
Blood pressure
Microcirculation dynamics
2.5 Pulmonary system
Respiratory movement and volumes
Gaseous exchange
Pulmonary circulation
Pulmonary function tests
2.6 Renal system
Regulation of water and osmolytes
Formation of urine
Acid-base balance
2.7 Endocrine system
Hypothalamus
Anterior and posterior pituitary
Adrenal medulla and cortex
Thyroid gland
Pancreatic hormones
Reproductive physiology
Required Text
R. Rhoades and R. Planzer. Human Physiology. 4th edition. Thomson Brooks/Cole. Pacific Grove,
CA. ISBN 0 03-032129-8, 2003.
TOTAL LECTURE HOURS: 45 HOURS
ACTIVE LEARNING ACTIVITIES: 48 HOURS
SMALL GROUP DISCUSSIONS: 5-6 HOURS
HANDS ON LABORATORY EXERCISES: 39 HOURS
There will be 2 two-hour exams and a final exam. Questions for will be drawn from lecture and
laboratory material, reading assignments, vocabulary, module objectives, and case studies. Each
exam will consist of short answers and multiple choice questions similar to professional board
exams. If you are going to be absent from an exam, bring your situation to our attention at least 48
hours before the exam is given and a make-up exam will be scheduled. Questions about exam
results must be resolved before the next exam is given. The final will be take place at 7:30 am
on Monday, December 12.
Dates
Fri. 9/30
Fri. 10/28
Mon. 12/12
Multiple
Event
Location
First Exam
Second Exam
Final (Third) Exam
Group Discussions of Case Studies
% of final grade
TBA
TBA
PLSCI 114
TBA
25%
25%
30%
~20%
Participation In The Case Studies
Case studies are small group learning experiences in which basic physiological science is
presentedin a clinical context. They will be are carried out in groups of 10 to 12 students under the
direction of one of your instructors. The cases allow students to see the relevance of the knowledge
that they gain in class within the context of basic and applied physiology. There will be 14 cases
during the 16 weeks duration of the physiology course, and each student is expected to attend 7
cases, on alternate weeks. All students are welcome to attend but not participate on assigned
cases. The evaluation of the case studies will be carried out by one of your instructors, who
evaluates each student individually. Participation in the case studies is mandatory. The criteria
used to evaluate the students in the case studies are as follows:
Presence and Alertness……………………………
Preparation……………………………………………
Evoked Participation…………………………………
Spontaneous Participation…………………………..
20%
30%
25%
25%
The grade obtained by the students in the case studies will count as 20% of the course final grade.
Students who do not attend a case study will receive a grade of 0%(zero). If the student has a valid
excuse for the absence, then he/she may be given the option of removing the grade by taking a
written test pertaining to the specific case study or arranging a discussion of the case with the
professor of the specific section. The grade assigned to the student in the specific case study will
be the grade obtained in this test or the evaluation carried out by the professor.
ISU Official Policy on Academic Integrity
Academic integrity is expected of all individuals in academe. Behavior beyond reproach must be the
norm. Academic dishonesty in any form is unacceptable. Academic dishonesty includes, but is not
limited to, cheating and plagiarism. CHEATING is defined as the act of using or attempting to use,
in examination(s) or other academic work, material, information, or study aids which are not
permitted by the instructor. PLAGIARISM is defined as representing another person’s words, ideas,
data or work as one’s own. Plagiarism includes, but is not limited to, the exact duplication of
another’s work and the incorporation of a substantial or essential portion thereof without appropriate
citation. Other examples of plagiarism are the acts of appropriating the creative works in such fields
as art, music and technology, or portions thereof, and presenting them as one’s own.
ISU Official Policy on Disabilities
Idaho State University, in the spirit and letter of the law, will make every effort to make reasonable
accommodations, according to Section 504 of the Rehabilitation Act of 1973 and the Americans
with Disabilities Act. ISU will not discriminate in the recruitment, admission, or treatment of students
or employees with disabilities. Students who believe they qualify for services under the Act should
contact The Office of Services for Students with Disabilities, Campus Box 8118, (208) 282-3599.
Please then meet with me privately to discuss how to accommodate any needs.
Handouts and Class Participation
Extensive copies of the lecture notes will not be available. Therefore, students are expected to
attend class and to take thorough notes during each class.
Lecture Schedule for Combined Module – OT, PA, PT and IDEP students
Week Lecture
Ken Rodnick
I.
1
2
3
4
II.
5
6
7
Date
Topic
Readings
8/22
8/23
8/24
8/26
8/29
8/30
8/31
9/2
Course introduction and expectations
Strategies for learning physiology
Chemical principles, Cell structure and function
Cell structure and function
Transport through the cell membrane
Transport through the cell membrane
Cellular control mechanisms
Case study 1 (Small group conference)
pp. 2-4, 11-21
pp. 22-27
Chapter 3
Curt Anderson
III.
9/5
8
9/6
9
9/7
9/9
Labor Day
The language of the nervous system
Functional organization of the nervous system
Case study 2 (Small group conference)
IV.
10
11
12
9/12
9/13
9/14
9/16
Fundamental neuroanatomy
The action potential
The action potential
Case study 3 (Small group conference)
V.
13
14
15
9/19
9/20
9/21
9/23
The synapse
Sensory systems
Sensory systems
Case study 4 (Small group conference)
16
17
18
9/26
9/27
9/28
9/30
9/30
Motor systems
Sensory and motor dysfunction
Autonomic nervous system
Case study 5 (Small group conference)
Examination 1
VI.
Chapter 4
Chapter 5
Chapter 7
Chapter 8
Chapter 9
Ken Rodnick
VII. 19
20
21
10/3
10/4
10/5
10/7
Skeletal muscle structure and function
Skeletal muscle structure and function
Metabolism and regulation of muscle contraction
Case study 6 (Small group conference)
Chapter 16
VIII. 22
23
24
10/10
10/11
10/12
10/14
Circulation (arteries and veins)
Circulation (capillaries)
Circulation (regulation, and disease)
Case study 7 (Small group conference)
Chapter 19
IX.
25
26
27
10/17
10/18
10/19
10/21
Heart mechanical function
Heart electrical function
Regulation of heart function
Case study 8 (Small group conference)
Chapter 18
X
28
29
30
10/24
10/25
10/26
10/28
Lung mechanics and function
Chapter 20
Pulmonary circulation and gas exchange
Chapter 21
Gas exchange and control of breathing and disease
Case study 9 (Small group conference) and Examination 2
Lecture Schedule for PA and IDEP Module
Curt Anderson
Week Lecture Date
Topic
XI
39
10/31
Kidney structure and function
40
11/01
Kidney structure and function
41
11/02
Formation of urine and micturition
42
11/04
Regulation of kidney function
XII
XIII
43
44
45
46
11/7
11/8
11/9
11/11
Acid-base physiology
Acid-base physiology
Energy balance and nutrition
Gastrointestinal system I
47
48
49
50
11/14
11/15
11/16
11/18
Regulation of GI function
Absorption
Endocrine control mechanisms
Pituitary hormones/ Adrenals
11/21
11/22
11/23
11/25
Thanksgiving Break
Thanksgiving Break
Thanksgiving Break
Thanksgiving Break
51
52
53
54
11/28
11/29
11/30
12/02
Adrenals continued
The endocrine pancreas
The endocrine pancreas
Growth
55
56
57
58
12/5
12/6
12/7
12/9
Reproductive physiology
Reproductive physiology
Pregnancy, Fetal development and lactation
Pregnancy, Fetal development and lactation
12/12
Final Exam 7:30-9:30am
XIV
XV
XVI
Readings
Chapter 23
Chapter 25
Chapter 22
Chapter 12
Chapter 13
Chapter 15
Chapter 14
Chapter 32