CURRICULUM VITAE
NAME: Yi-Hsin Weng/ 翁意欣
SEX: Female
BIRTH DATE: February 21, 1968
BIRTH PLACE: Chayi, Taiwan
CITIZENSHIP: Taipei, Taiwan
OFFICE ADDRESS & TELEPHONE NO:
Neurology Department, Chang Gung Memorial Hospital and University
199, Tung Hwa North Road, Taipei, Taiwan.
TEL: (03) 3281200-8412, 8418
CHINESE PERMANENT REGISTRATION NO: Q220145837
LANGUAGE: Chinese, English
EDUCATION:
1986-1993
M.D. Chung-Shan Memorial Medical College of Medicine,
Taichung, Taiwan
2007~
Ph.D Chang Gung University, Graduate Institute of Clinical Medical
Sciences, Taoyuan, Taiwan
EMPLOYMENTS:
1998-Present
Attending Physician, Department I of Neurology,
Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan
1997-1998
Fellowship, Department of Neurology,
Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan
1993-1997
Resident Physician, Department of Neurology;
Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan
1
BOARD CERTIFICATION:
1996
Specialist of Neurology,
Certification No.: 000405
2003
Specialist of critical care medicine
Certification No: SC1286
MEDICAL LICENSE:
Chinese license No.: 024115
PROFESSIONAL AFFILIATIONS:
1.
1998-Present : Section of Movement Disorders, Department of Neurology,
Chang Gung Memorial Hospital and University
2.
2005: Neuroscience Research Center, Chang Gung Memorial Hospital and
University
3.
1998-Present: International Movement Disorders Society
4.
1997-Present: American Academy of Neurology
5.
1993-Present: Taiwan Neurological Society
6.
1993-Present: Formosan Medical Association, R.O.C. (Taiwan)
7.
2003-Present: Taiwan Society of Critical Care Medicine
PROFESSIONAL ACTIVITES:
1.
A member of Intensive Care Committee of Change Gung Memorial Hospital
2.
The head of Neurology Intensive Care Unit
3.
Inviting Speaker of the Annual Symposium of Taiwan Neurological Society,
2000.
4.
Inviting Speaker of the Annual Symposium of Taiwan Neurological Society,
2002.
5.
Inviting Speaker of the Annual Symposium of Taiwan Neurological Society,
2003.
6.
Inviting Speaker: Update of Neuroimaging in Parkinson, 2005, Taiwan
7.
Inviting Speaker: International Congress of Neuroscience and Molecular
Imaging. 2006.
2
RESEARCH INTEREST:
1.Movement disorders
2.Parkinson’s Disease
3.Functional Neuroimaging
4.Neurodegenerative Disease
5.Transgenic Mice
BIOBOLOGY:
A. Publications
1.
Tzu-Chen Yen, Chin-Song Lu, Kai-Yuan Tzen, Shiaw-Pyng Wey, Yah-Huei Wu
Chou, Yi-Hsin Weng, Pan-Fu Kao, Gann Ting. Decreased dopamine transporter
binding in Machado-Joseph disease. Journal Nuclear Medicine 2000;
41(6):994-998.(SCI)
2.
Yi-Hsin Weng, Pan-Fu Kao, Chon-Haw Tsai, Tzu-Chen Yen, Chin-Song Lu.
Dopamine deficiency in rubral tremor caused by midbrain hemangioma: case report.
Chang Gung Medical Journal 2000; 23(8):485-491.
3.
Pan-Fu Kao, Kai-Yuan Tzen, Tzu-Chen Yen, Chin-Song Lu, Yi-Hsin Weng,
Shiaw-Pyng Wey, Gann Ting. The optimal imaging time for
[99Tcm]TRODAT-1/SPET in normal subjects and patients with Parkinson's
disease. Nuclear Medicine Communications 2001; 22(2):151-154.(SCI)
4.
Chin-Song Lu, Yi-Hsin Weng, Chon-Haw Tsai, Rou-Shayn Chen, Jiann Der Lee,
Shin-Tseng Lee. Posteroventral pallidotomy for advanced Parkinson’s disease.
Chang Gung Medical Journal 2001; 24(7):409-417.
5.
Yi-Hsin Weng, Tzu-Chen Yen, Chin-Song Lu. Parkinsonian syndromes associated
with hydrocephalus. Annal of Nuclear Medicine Science 2002; 15(2):97-102.(SCI)
6.
Chin-Chang Huang*, Tzu-Chen Yen, Yi-Hsin Weng, Chin-Song Lu. Normal
dopamine transporter binding in dopa responsive dystonia. Journal of Neurology
2002; 249(8):1016-1020.(SCI)
3
7.
CH Tsai*, SK Lo, LC See, HZ Chen, RS Chen, Yi-Hsin Weng, FC Chang, CS Lu.
Environmental risk factors of young onset Parkinson’s disease: a case-control study.
Clinical Neurology and Neurosurgery 2002; 104(4):328-333. (SCI)
8.
Chin-Chang Huang*, Yi-Hsin Weng, Chin-Song Lu, Nai-Shin Chu, Tzu-Chen
Yen. Dopamine transporter binding in chronic manganese intoxication. Journal of
Neurology 2003; 250(11):1335-1339.(SCI)
9.
Szu-Chia Lai, Yi-Hsin Weng, Tzu-Chen Yen, Cheng-Chien Tsai, Hsiu-Chen
Chang, Shiaw-Pyng Wey, Ting Gann, Chin-Song Lu. Imaging early stage
corticobasal degeneration with [99mTc] TRODAT-1 SPET. Nuclear Medicine
Communications 2004; 25(4):339-345. (SCI)
10. Chin-Song Lu, Yi-Hsin Weng, Min-Chi Chen, Rou-Shayn Chen, Kai-Yuan Tzen,
Shiaw-Pyng Wey, Gann Ting, Hsiu-Chen Chang, Tzu-Chen Yen.
99mTc-TRODAT-1 imaging of multiple system atrophy. Journal of Nuclear
Medicine 2004; 45(1):49-55.(SCI)
11. Yi-Hsin Weng, Tzu-Chen Yen, Min-Chi Chen, Pan-Fu Kao, Kai-Yuan Tzen,
Rou-Shayn Chen, Shiaw-Pyng Wey, Gann Ting, Chin-Song Lu. Sensitivity and
Specificity of [99mTc]TRODAT-1 SPECT Imaging in Differentiating Patients
with Idiopathic Parkinson’s Disease from Healthy Subjects. Journal of Nuclear
Medicine 2004; 45(3):393-401.(SCI)
12. Chin-Song Lu, Yah-Huei Wu Chou, Pei-Chi Kuo, Hsiu-Chen Chang, Yi-Hsin
Weng. The parkinsonian phenotype of spinocerebellar ataxia type 2. Archives of
Neurology 2004; 61(1):35-38.(SCI)
13. Chin-Song Lu, Hsiu-Chen Chang, Pei-Chi Kuo, Yu-Lun Liu, Wen-Shiang Wu,
Yi-Hsin Weng, Tzu-Chen Yen, Yah-Huei Wu Chou*. The parkinsonian phenotype
of spinocerebellar ataxia type 3 in a Taiwanese family. Parkinsonism & Related
Disorders 2004; 10(6):369-373.(SCI)
14. Chon-Haw Tsai, Fang-Chia Chang, Chin-Song Lu, Shin-Tseng Lee, Yu-Ting
Huang, Ming-Kuei Lu, Rou-Shayn Chen, Tony Wu, Jiann-Der Lee, Yi-Hsin Weng,
Hsiu-Chen Chang. Pallidotomy effect on the cortical excitability in patients with
severe Parkinson's disease. Movement Disorders. 2005; 20(4):463-470.(SCI)
4
15. Chin-Song Lu, Erick J. Simons, Yah-Huei Wu Chou, Alessio Di Fonzo, Hsiu-chen
Chang, Rou-Shayn Chen, Yi-Hsin Weng, Christan F. Rohe, Guido J.Breedveld,
Nobutaka Hattori, Thomas Gasser, Ben A.Oostra, Vincenzo Bonifati. The LRRK2
I2012T, G2019S, and I2020T mutations are rare in Taiwanese patients with
sporadic Parkinson's disease. Parkinsonism & Related Disorders 2005;
11(8):521-522.(SCI)
16. Yen-Wen Lin, Hsiu-Chen Chang, Yah-Huei Wu Chou, Rou-Shayn Chen, Wen-Chi
Hsu, Wen-Shiang Wu, Yi-Hsin Weng, Chin-Song Lu*. DYT1 Mutation in a
Cohort of Taiwanese Primary Dystonias. Parkinsonism & Related Disorders 2006;
12(1):15-19.(SCI)
17. Yen-Wen Lin; Shinn-Kuang Lin, Yi-Hsin Weng. .Fatal paranasal sinusitis
presenting as trigeminal neuralgia: case report. Headache 2006;
46(1):174-178.(SCI)
18. Chin-Song Lu, Yah-Huei Wu Chou, Yi-Hsin Weng, Rou-Shayn Chen. Genetic
and DAT imaging studies of familial parkinsonism in a Taiwanese cohort. Journal
of Neural Transmission (Suppl).2006; 70:235-240.(SCI)
19. Alessio Di Fonzo, Yah-Huei Wu-Chou, Chin-Song Lu, Marina van Doeselaar1,
Erik J. Simons, Christan F. Rohé, Hsiu-Chen Chang, Rou-Shayn Chen,
Yi-Hsin Weng, Nicola Vanacore, Guido J. Breedveld, Ben A. Oostra and
Vincenzo Bonifati. A common missense variant in the LRRK2 gene, Gly2385Arg,
associated with Parkinson’s disease risk in Taiwan. Neurogenetics 2006;
7(3):133-138.( SCI)
20. Yi-Hsin Weng, Yah-Huei Wu Chou, Wen-Shiang Wu, Kun-Ju Lin, Hsiu-Chen
Chang, Tzu-Chen Yen, Rou-Shayn Chen, Shiaw-Pyng Wey, Chin-Song Lu. PINK1
Mutation in Taiwanese Early-Onset Parkinsonism:Clinical, Genetic, and Dopamine
Transporter Studies. Journal of Neurology. 2007; 254(10):1347-1355.(SCI)
21. Jiann-Der Lee, Chung-Hsien Huang, Yi-Hsin Weng, Kun-Ju Lin, Chin-Tu Chen.
Improved accuracy of brain MRI/SPECT registration using a 2-cluster SPECT
normalization algorithm and a combinative similarity measure: Application to the
evaluation of Parkinson’s disease. Annals of Nuclear Medicine. 2007;
21(4):197-207. (SCI)
5
22. Jiann-Der Lee, Chung-Hsien Huang, Yi-Hsin Weng, Kun-Ju Lin, Chin-Tu Chen.
An automatic MRI/SPECT registration algorithm using image intensity and
anatomical feature as matching characters: application on the evaluation of
Parkinson's disease. Nuclear Medicine and Biology. 2007; 34(4):447-457. (SCI)
23. Chin-Song Lu, Hsiu-Chen Chang, Yi-Hsin Weng, Rou-Shayn Chen, Vincenzo
Bonifati, Yah-Huei Wu-Chou*. Analysis of the LRRK2 Gly2385Arg variant in
primary dystonia and multiple system atrophy in Taiwan. Parkinsonism & Related
Disorders. 2008; 14(5):393-396.( SCI)
24. Chi-Hong Wang, Yau-Yau Wai, Yi-Hsin Weng, Jen Fang Yu, Jiun Jie Wang*.
The cortical modulation from the external cues during gait observation and
imagination. Neuroscience Letters .2008; 443(3):232-235.( SCI)
25. Chin-Song Lu, Yah-Huei Wu-Chou, Marina van Doeselaar, Erik J. Simons,
Hsiu-Chen Chang, Guido J. Breedveld, Alessio Di Fonzo, Rou-Shayn Chen ,
Yi-Hsin Weng, Szu-Chia Lai, Ben A Oostra, Vincenzo Bonifati. The LRRK2
Arg1628Pro variant is a risk factor for Parkinson’s disease in the Chinese
population. Neurogenetics. 2008; 9(4):271-276. (SCI)
26. Ying-Zu Huang, Szu-Chia Lai, Chin-Song Lu, Yi-Hsin Weng, Wen-Li Chuang,
Rou-Shayn Chen*. Abnormal cortical excitability with preserved brainstem and
spinal reflexes in sialidosis type I. Clinical Neurophysiology. 2008;
119(5):1042-1050. (SCI)
27. Ying-Zu Huang, John C. Rothwell, Chin-Song Lu, Jiun-Jie Wang, Yi-Hsin Weng,
Szu-Chia Lai, Wen-Li Chuang, June Hung, Rou-Shayn Chen*. The effect of
continuous theta burst stimulation over premotor cortex on circuits in primary
motor cortex and spinal cord. Clinical Neurophysiology. 2009;
120(4):796-801.( SCI)
28. Szu-Chia Lai, Rou-Shayn Chen, Yah-Huei Wu-Chou , Hsiu-Chen Chang, Ling-Yu
Kao, Ying-Zu Huang, Yi-Hsin Weng, Jun-Kan Chen, Wu-Liang Hwu, Chin-Song
Lu. A longitudinal study of Taiwanese Sialidosis type 1: an insight into the concept
of cherry-red spot myoclonus syndrome. European Journal of Neurology. 2009;
16(8):912-919. (SCI)
6
29. Jiun-Jie Wang, Yau-Yau Wai, Yi-Hsin Weng, Koon-Kwan Ng,Ying-Zu Huang,
Leslie Ying, Hao-Li Liu, Chi-Hong Wang. Functional MRI in the assessment of
cortical activation during gait-related imaginary tasks. Journal of Neural
Transmission.2009; 116(9):1087-1092. (SCI)
30. HY Hsu, CC Chen, TT Huang, YH Weng , CS Lu. Fatigue and related factors in
patients with Parkinson's disease. Hu Li Za Zhi. 2009 Oct; 56(5):49-59.
31. Tan EK, Lu CS, Peng R, Teo YY, Wu-Chou YH, Chen RS, Weng Yi-Hsin, Chen
CM, Fung HC, Tan LC, Zhang ZJ, An XK, Lee-Chen GJ, Lee MC, Fook-Chong S,
Burgunder JM, Wu RM, Wu YR. Analysis of the UCHL1 genetic variant in
Parkinson's disease among Chinese. Neurobiology of Aging. 2010;
31(12):2194-2196. (SCI)
32. Yah-Huei Wu-Chou , Tu-Hsueh Yeh , Chuan-Yu Wang , Juei-Jueng Lin ,
Chin-Chang Huang , Hsiu-Chen Chang, Szu-Chia Lai, Rou-Shayn Chen, Yi-Hsin
Weng, Chia-Ling Huang , Chin-Song Lu*.High frequency of multiexonic deletion
of the GCH1 gene in a Taiwanese cohort of dopa-response dystonia. American
Journal of Medical Genetics Part B: Neuropsychiatric Genetics.2010; 153B
(4):903-908. (SCI)
33. An-Hsun Chou, Chia-Yang Chen, Si-Ying Chen, Wei-June Chen, Ying-Ling Chen,
Yi-Hsin Weng, Hung-Li Wang* . Polyglutamine-expanded ataxin-7 causes
cerebellar dysfunction by inducing transcriptional dysregulation. Neurochemistry
International. 2010; 56(2):329-339. (SCI)
34. Lin WY, Lin KJ, Weng YH, Yen TC, Shen LH, Liao MH, Lu CS. Preliminary
studies of differential impairments of the dopaminergic system in subtypes of
progressive supranuclear palsy. Nuclear Medicine Communications. 2010;
31(11):974-980. (SCI)
35. Kun-Ju Lin+, Yi-Hsin Weng+, Shiaw-Pyng Wey, Ing-Tsung Hsiao, Chin-Song Lu,
Daniel Skovronsky, Hsiu-Ping Chang, Mei-Ping Kung , Tzu-Chen Yen.
Whole-Body Biodistribution and Radiation Dosimetry of 18F-FP-(+)-DTBZ
(18F-AV-133)：a Novel Vesicular Monoamine Transporter 2 Imaging Agent. The
Journal of Nuclear Medicine. 2010; 51(9):1480-1485. (SCI)
7
36. Wang HL, Chou AH, Lin AC, Chen SY, Weng YH, Yeh TH.
Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in
cerebellar and inferior olivary neurons. Experimental Neurology. 2010;
224(2):486-494. (SCI)
37. Chen P, Lin JJ, Lu CS, Ong CT, Hsieh PF, Yang CC, Tai CT, Wu SL, Lu CH,
Hsu YC, Yu HY, Ro LS, Lu CT, Chu CC, Tsai JJ, Su YH, Lan SH, Sung SF,
Lin SY, Chuang HP, Huang LC, Chen YJ, Tsai PJ, Liao HT, Lin YH, Chen CH,
Chung WH, Hung SI, Wu JY, Chang CF, Chen L, Chen YT, Shen CY; Taiwan
SJS Consortium(…Weng YH). Carbamazepine-induced toxic effects and
HLA-B*1502 screening in Taiwan. New England Journal of Medicine. 2011;
364(12):1126-1133. (SCI)
38. CL Huang+, YH Wu-Chou+, SC Lai, HC Chang, TH Yeh, YH Weng, RS Chen,
YZ Huang, CS Lu*. Contribution of glucocerebrosidase mutation in a large
cohort of sporadic Parkinson’s disease in Taiwan. European Journal of
Neurology. 2011; 18(10):1227-1232. (SCI)
39. Chou AH, Chen SY, Yeh TH, Weng YH, Wang HL. HDAC inhibitor sodium
butyrate reverses transcriptional downregulation and ameliorates ataxic
symptoms in a transgenic mouse model of SCA3. Neurobiology of Disease.
2011; 41(2):481-488. (SCI)
40. HL Wang*, AH Chou, AS Wu, SY Chen, YH Weng, YC Kao, TH Yeh, PJ Chu,
CS Lu. PARK6 PINK1 mutants are defective in maintaining mitochondrial
membrane potential and inhibiting ROS formation of substantia nigra
dopaminergic neurons. Biochimica et Biophysica Acta-Molecular Basis of
Disease. 2011; 1812(6):674-684. (SCI)
41. Wang JJ, Lin WY, Lu CS, Weng YH, Ng SH, Wang CH, Liu HL, Hsieh RH, Wan
YL, Wai YY. Parkinson’s Disease : Diagnostic Utility of Diffusion Kurtosis
Imaging. Radiology. 2011; 261(1)210-217. (SCI)
42. Lin KJ, Lin WY, Hsieh CJ, Weng YH, Wey SP, Lu CS, Skovronsky D, Yen TC,
Chang CJ, Kung MP, Hsiao IT. Optimal scanning time window for
(18)F-FP-(+)-DTBZ ((18)F-AV-133) summed uptake measurements. Nuclear
Medicine and Biology. 2011; 38(8):1149-1155. (SCI)
8
43. Yau Yau Wai, Jiun Jie Wang, Yi-Hsin Weng, Wey Yil Lin, Hon Kwong Ma, Shu
Hang Ng, Yung Liang Wan, Chi Hong Wang. Cortical involvement in a
gait-related imagery task：Comparison between Parkinson’s disease and normal
aging. Parkinsonism and Related Disorders. 2012; 18(5):537-542. (SCI)
44. Chu-Yu Chen+, Yi-Hsin Weng+, Kun-Yi Chien, Kun-Ju Lin, Tu-Hsueh Yeh,
Yi-Ping Cheng, Chin-Song Lu, Hung-Li Wang. (G2019S) LRRK2 activates
MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a
transgenic mouse model of PD. Cell Death and Differentiation. 2012.04.27 [Epub
ahead of print].
(SCI)
45. Ko-Ting Chao, Hsin-Hsin Tsao, Yi-Hsin Weng, Ing-Tsung Hsiao, Chia-Ju Hsieh,
Shiaw-Pyng Wey, Tzu-Chen Yen, Mei-Ping Kung, Kun-Ju Lin*. Quantitative
Analysis of Binding Sites for 9-Fluoropropyl-(+)-dihydrotetrabenazine
([18F]AV-133) in a MPTP-Lesioned PD Mouse Model. Synapse. 2012
Sep ;66(9):823-831. [Epub] 2012 Jin 13.
(SCI)
46. Chin-Song Lu, Szu-Chia Lai, Ruey-Meei Wu, Yi-Hsin Weng, Chia-Ling Huang,
Rou-Shayn Chen, Hsiu-Chen Chang, Yah-Huei Wu-Chou*, Tu-Hsueh Yeh*.
PLA2G6 mutations in PARK14-linked young-onset parkinsonism and sporadic
Parkinson's disease. American Journal of Medical Genetics Part B:
Neuropsychiatric Genetics. 2012 March; 159B(2):183-191. (SCI)
B. Presentations
1.
Poster: Choriocarcinoma presenting as an intracardiac mass and young stroke—a
case report. Yi Hsin Weng, Yi Ro Wu.
Annual Meeting of Neurological Society. Taipei, April, 1996.
2.
Poster: The reciprocal inhibition in patients with dopa-responsive dystonia after
L-dopa treatment. Yi Hsin Weng, Rou Shayn Chen.
Annual Meeting of Neurological Society. Taipei, April 1997.
3.
Oral: Intermittent subcutaneous pen injected apomorphine for clinical fluctuation
of Parkinson’s disease. Yi Hsin Weng, Chon Haw Tsai, Chin Song Lu.
Annual Meeting of Neurological Society. Taipei, April 1999.
9
4.
Poster: 99m TC-TRODAT-1 SPECT imaging of dopamine transporters in
differential diagnosis of Parkinson’s disease and other parkinsonism. Chin Song Lu,
Yi Hsin Weng, Tzu Chen Yeh, Pan Fu Kao, Chon Haw Tsai, Rou Shayn Chen,
Kai Yuan Tzen.
52th Annual Meeting of American Academy of Neurology, San Diego, 2000.
5.
Oral: 99m TC-TRODAT-1 SPECT imaging of dopamine transporters in healthy
subjects and Parkinson’s disease patients. Yi Hsin Weng, Chin Song Lu, Tzu Chen
Yeh, Pan Fu Kao, Chon Haw Tsai, Rou Shayn Chen, Kai Yuan Tzen.
52th Annual Meeting of American Academy of Neurology, San Diego, 2000.
6.
Poster: Yi-Hsin Weng, Tzu-Chen Yen, Pan-Fu Kao, et al. [99mTc]TRODAT-1
SPECT imaging of dopamine transporters in healthy subjects and Parkinson’s
disease patients. Neurology 2000; 54: A330.
7.
Poster: [99mTc]TRODAT-1 SPECT Study In Reversible Parkinsonism Associated
With Viral Encephalitis: A Case Report. 趙昌宏,翁意欣*, 劉祥仁, 高潘福, 閻
紫宸.
Annual Meeting of Neurological Society. Taichung, 2001.
8.
Poster: Aging is not a Major Cause of Idiopathic Parkinson’s Disease Assessed by
[99mTc]TRODAT-1 SPECT Imaging. Yi Hsin Weng, Tzu-Chen Yen, Pan-Fu Kao,
Rou-Shyan Chen, Chon –Haw Tsai, Chin-Song Lu.
54th Annual Meeting of American Academy of Neurology, Barcelona, 2002.
9.
Poster: Assessment of The Rate of Progression in Parkinson’s Disease By
[99mTc]TRODAT-1 SPECT imaging. Yi-Hsin Weng, Rou-Shayn Chen; Chin-Song
Lu, Tzu-Chen Yen, Pan-Fu Kao.
International Congress of Parkinson's Disease and Movement Disorders,
Helsinki, Finland. 2002.
.
10. Poster: Hirayama Disease: Anterior Horn Cell Disease or Cervical Myelopathy?
-----A Case Report. Hsiu-Ping Chang; Yi-Hsin Weng.
Annual Meeting of Neurological Society. Taipei, 2002.
10
11. Poster: Aging process of dopamine transporter is faster in young healthy subjects
before 45 years of age. Yi Hsin Weng, Chin-Song Lu, Tzu-Chen Yen.
8th International Congress of Parkinson's Diseases and Movement Disorders,
Roma, 2004.
12. Poster: Streptococcus suis Meningitis and Deafness in Adult Patient--- A case
report. JR Huang; Yi-Hsin Weng.
Annual Meeting of Neurological Society. Taipei, 2004.
13. Poster: 99mTc-TRODAT-1 單光子射出電腦斷層攝影在診斷帕金森症候群之
準確性 Yin-Yin Lee; Yi-Hsin Weng*; Kun-Ju Lin.
Annual Meeting of Neurological Society. Taichung, 2006.
14. Poster: Dopamine Transporter Imaging in Subjects Carrying LRRK2 G2385R
Mutation. Yi-Hsin Weng, Chin-Song Lu, Kun-Ju Lin.
8th International Conference of Alzheimer’s and Parkinson’s Diseases: progress
and New Perspectives. Salzburg, Austria, 2007.
15.
Poster: Depression and Dementia in Patients with Parkinson’s Disease.
Yi-Hsin Weng, Chin-Song Lu, Kun-Ju Lin, Tzu-Chen Yen, Lie-Hang Shen.
2009 年神經醫學聯合學術研討會
16. Poster: Cerebral glucose metabolism in PD patients with and without dementia.
Yi-Hsin Weng, Kun-Ju Lin, Chin-Song Lu, Tzu-Chen Yen, Lie-Hang Shen.
13th International Congress of Parkinson’s Disease and Movement Disorders.
Paris, France, 2009.
17. Poster:腦部葡萄糖代謝影像在巴金氏病病患有無失智症中的差異. 翁意欣、陸
清松、沈立漢、廖美秀、林昆儒. Annals of Nuclear Medicine and Sciences. Vol 22
suppl, S46 Sep 2009. 中華民國核醫學年會.
18. Poster: Genetic contribution to young onset dystonia in a Taiwanese cohort.
CS Lu*, YH Wu-Chou, HC Chang, TH Yeh, SC Lai, RS Chen, YH Weng.
18th WFN World Congress on Parkinson’s Disease and Related Disorders,
Dec 13-16, 2009 in Miami.
11
19. Poster: PLA2G6 mutations in a Taiwanese cohort of early onset parkinsonism. YH
Wu-Chou, CS Lu*, HC Chang, RS Chen, YH Weng, SC Lai, TH Yeh.
18th WFN World Congress on Parkinson’s Disease and Related Disorders,
Dec 13-16, 2009 in Miami.
20. Poster: Study of the SGCE gene in Tourette’s syndrome patients of Taiwanese. CS
Lu, WY Lin, HC Chang, SC Lai, TH Yeh, YH Weng, RS Chen, CL Huang, YH
Wu-Chou*. 14th International Congress of Parkinson’s Disease and Movement
Disorders, June 13-17, 2010 in Buenos Aires.
21. Poster: Analysis of Asp331Tyr variant of PLA2G6 in Taiwanese Parkinson’s
disease. CS Lu, SC Lai, RM Wu, CL Huang, TH Yeh, YH Weng, RS Chen, HC
Chang, YH Wu-Chou.14th International Congress of Parkinson’s Disease and
Movement Disorders, June 13-17, 2010 in Buenos Aires.
22. Poster: Positron Emission Tomography Imaging with A Novel Vesicular
Monoamine Transporter 2 Ligand (18F-FP-(+)-DTBZ) in Patients with Parkinson
Disease and Healthy Subjects. Yi-Hsin Weng, Kun-Ju- Lin, Hui-Ching Kang,
Chin-Song Lu, Wey-Yil Lin, Tzu-Chen Yen.
The 10th International Congress on Alzheimer's & Parkinson's Diseases.
Barcelona, Spain, 2011.
23. Poster: Clinical and Neuroimaging studies in Vascular Parkinsonism and Vascular
Dementia. Yi-Hsin Weng , Rou-Shayn Chen, Kun-Ju Lin, Chin-Song Lu,
Tzu-Chen Yen.
The MDS 15th International Congress of Parkinson's Disease and Movement
Disorders. Toronto, Canada, 2011.
24. Poster: 18F-DTBZ PET Imaging in patients with Parkinson’s Disease and
Progressive supranuclear palsy. Yi-Hsin Weng, Kun-Ju Lin, Ing-Tsung Hsiao,
Chia-Ju Hsieh, Wei-Yil Lin, Rou-Shayn Chen, Ying-Zu Huang, Szu-Chia Lai,
Wen-Li Chung, Tu-Hsueh Yeh, Tzu-Chen Yen, Mei-Ping Kung, Daniel
Skovronsky, Chin-Song Lu.
The MDS 16th International Congress of Parkinson's Disease and Movement
Disorders. Dublin, Ireland, 2012.
12
25. Poster: 18F-DTBZ (AV-133) PET imaging in parkin related Parkinson’s disease.
Chin-Song Lu, Wei-Yi Lin, Kun-Ju Lin, Ing-Tsung Hsiao, Chia-Ju Hsieh,
Yah-Huei Wu-Chou, Szu-Chia Lai, Wen-Li Chung, Jung Hung, Tu-Hsueh Yeh,
Chiung-Chu Chen, Ying-Zu Huang, Rou-Shayn Chen, Mei-Ping Kung, Tzu-Chen
Yen, Daniel Skovronsky, Yi-Hsin Weng.
The MDS 16th International Congress of Parkinson's Disease and Movement
Disorders. Dublin, Ireland, 2012.

RESEARCH PROJECT
1.
以 99mTC-TRODAT-1 鎝製劑的單光子射出電腦斷層攝影診斷帕金森病
---主持人-----------2000 年長庚醫學研究計劃(CMRP957)
2.
以[99mTc] TRODAT-1 SPECT 影像來早期鑑別診斷帕金森病,多發性系統萎
縮症及血管性帕金森症的研究
---主持人--------2001 年國科會 (NMRPG0073；NSC90-2314-B-182 A-08)
3.
以[99mTc]TRODAT-1 SPECT 來評估帕金森氏症的退化速度
---主持人----------2002 年國科會(NMRPG1041；NSC91-2314-B182A-056)
4.
theta-burst 重複性穿顱磁刺激對正常人與帕金森病患者之大腦可塑性的影
響
---主持人------2005 年國科會(NMRPG340371；NSC94-2314-B-182A-066)
5.
parkin 基因突變病人之臨床症狀與黑質細胞退化程度之分歧:以動作關聯電
位與功能性神經造影分析腦皮質之可塑性
---主持人-----------2006 年國科會(NMRPG350071；
NSC95-2314-B-182A-069)
6.
帕金森症的非運動障礙症狀之前瞻性研究
---主持人-----------2005~2007 年長庚醫學研究計劃-整合型神經科學研究中
心子計劃(CMRPG34007)
7.
LRRK2-G2385R 基因突變在帕金森病所扮演的角色: 病人與無症狀帶因者
的臨床、心智、電氣生理學，以及功能性神經造影研究
---主持人----2007~2010 年國科會
(NMRPG366191~3；NSC 96-2314-B-182A-104-MY3)
13
8.
以基因轉殖鼠模式探討突變(G2385R)LRRK2 引起帕金森病的致病機轉
---主持人-----------2007 年長庚醫學研究計劃(CMRPG361311)
9.
退化性神經疾病之診療之學術研究用臨床試驗
---主持人-----------2007 年行政院原子能委員會核能研究所委託
(GMRPG370021；962016L)
10. 以基因轉殖鼠模式探討突變(G2385R)LRRK2 引起帕金森病的致病機轉
---主持人-----------2008 年長庚醫學研究計劃(CMRPG371171)
11. 功能性神經影像用於鑑別診斷帕金森症
---主持人-----------2008 年行政院原子能委員會核能研究所委託
(GMRPG370151；970947L)
12. 功能性神經影像用於鑑別診斷帕金森症
---主持人-----------2009 年行政院原子能委員會核能研究所委託
(GMRPG380121；NL0981377)
13. 以基因轉殖鼠模式探討突變(G2385R)LRRK2 引起帕金森病的致病機轉
---主持人-----------2009 年長庚醫學研究計劃(CMRPG381161)
14. 以囊泡單胺轉運體正子攝影(18F-DTBZ PET)鑑別診斷帕金森病與帕金森
症(1/2)
---主持人----2010~2012 年國科會
(NMRPG396161~2；NSC 99-2314-B-182A-067-MY2)
15. 以基因轉殖鼠模式探討突變(G2385R)LRRK2 引起帕金森病的致病機轉
---主持人-----------2010 年長庚醫學研究計劃(CMRPG392001)
16. 利用 Tc-99m TRODAT-1 腦部斷層掃描鑑別診斷巴金森氏病與血管性巴金
森症狀群之研究
---共同主持人------ 2000 年國科會(NSC
89-2314-B-182A-108-M08)
17. 改進核醫腦部受體/轉運體造影的定性及定量品質暨建立自動分析診斷專
家系統
---共同主持人------2005~2007 年長庚醫學研究計劃-整合型神經科學研究中
心子計劃(CMRPG34006)
14
18.
99m
Tc-TRODAT 單光子電腦斷層掃描在遺傳性腦神經退化病變(遺傳性巴
金森氏病和遺傳性巴金森症狀群)之應用(99mTc-TRODAT 新適應症)
---共同主持人------2006 年國科會(NSC 95-2623-7-182A-001-NU)
19. 改善核醫腦部核醫造影的定性及定量品質暨建立自動分析專家系統
---共同主持人------2005/2006 年國科會(NSC 95-2314-B-182A-125)
20. 整合型長庚醫療體系腦中風登錄子計劃五：腦中風之後的認知功能障礙與
帕金森症
---共同主持人-----2006~2009 年長庚醫學研究計劃(CMRPG350771~3)
21. 正常人及帕金森氏症病人行動控制及動作表現之磁振造影研究分析
---共同主持人------2007/2008 年國科會 NSC (96-2321-B-182-002-MY2)
22. 帕金森氏症病人之矛盾步伐之探討：皮質之作用以及功能代謝之測量
---共同主持人-----2007~2010 年長庚醫學研究計劃(計畫主持人：衛優遊)
(CMRPG360821~3)
23. 路易氏體失智症和阿茲海默氏病和帕金森氏病併失智症之鑑別診斷：臨床
表徵、生物標記和神經影像學研究
---共同主持人------2008 年國科會(NSC 97-2314-B-182A-050)
24. 嶄新核醫藥物 18F 標記 VMAT2 藥物 FP-(+)-DTBZ 的動物生物分布、
藥物動力學、以及臨床第一期人體試驗(計畫主持人：林昆儒)
---共同主持人------2009~2011 年國科會(NSC 98-2314-B-182-034-MY2)
25. 以分子基因學,功能性腦影像學,神經電生理學等多面性研究來探討肌張力
不全症-帕金森氏症的病態生理機制(1/3)
---共同主持人------2010~2013 年國科會(計畫主持人：陸清松)
(NMRPD190391~3；NSC 99-2314-B-182-027-MY3)
26. 18F-DTBZ 第二期人體試驗：以囊泡單胺轉運體正子攝影鑑別診斷帕金森
病以及監測疾病嚴重度
---共同主持人-----2010~2013 年長庚醫學研究計劃(計畫主持人：陸清松)
(CMRPG390911~3)
27. 帕金森氏病人的囊泡單胺轉運體造影與臨床評估長期追蹤臨床試驗
---共同主持人------2011~2014 年國科會(計畫主持人：林昆儒)
(NMRPD1A0771~3；NSC 100-2314-B-182-036-MY3)
15
28. 利用小鼠模式探討帕金森病的分子病理機轉、生物標記與治療方法—利用
基因嵌入小鼠模式探討第六型遺傳型帕金森病的分子病理機轉(子計畫二)
(1/3)
---共同主持人------2011 年國科會(計畫主持人：葉篤學)
(NMRPG3A0271；NSC 100-2321-B-182A-004)
29. 利用小鼠模式探討帕金森病的分子病理機轉、生物標記與治療方法—從小
鼠模式到病人：發展全新之 18F-DTBZ 正子影像作為追蹤 PARK6 及 PARK8
帕金森病神經退化的生物標記(子計畫三) (1/3)
---共同主持人------2011 年國科會(計畫主持人：陸清松)
(NMRPD1A1361；NSC 100-2321-B-182-012)
16