ISHAM Working Group on Fungal infections in cystic fibrosis (November 2007)
With the organization of the second meeting of the ECMM/ISHAM Working group on
Pseudallescheria/Scedosporium infections, little has been done at the moment in our newly
approved working group. Nevertheless, some collaborative works have already been
initiated :
- An epidemiological study has been initiated involving several university hosiptals in France
with the objective to get a better knowledge of the diversity of the filamentous fungi
colonizing the airways of CF patients, the clinical releavance of this colonization and to
define guidelines for the mycological examnation of sputum samples. Seven University
Hospitals (Lille, Dunkerque, Rouen, Dijon, Grenoble, Angers and Bordeaux) are involved in
this study coordinated by Laurence Delhaes and supported by the french Ministry of Health,
the french association “Vaincre la Mucoviscidose”, and Pfizer Laboratories.
- A collaborative work has been initiated between the Host-Parasite Interaction Study Group
and Pr. Tsung Chain Chang from the University of Tainan in Taiwan dealing with the
development of DNA chips for the molecular detection and direct identification of fungi
colonizing the airways of CF patients from respiratory secretions.
- Genomic and proteomic studies of Aspergillus fumigatus isolates recovered from respiratory
secretions of CF patient have been initiated in a project coordinated by Françoise Symoens
(Brussels, Belgium) and involving Tom Coenye (University of Ghent, Belgium), the HostParasite Interaction Study Group (Angers, France) and Claudine Pinel and Renée Grillot
(University Hospital of Grenoble, France).
- Collaborative works have been initiated between the host-Parasite Interaction Study Group
and SONAS (also from Angers University, France) for the search for new azole drugs efficent
against Scedosporium species, and the characterization of siderophores produced by these
fungi.
Additionally, a letter has been sent to Philippe Arhets, the Deputy-Director for European
Affairs in France, for the preparation of the third call for proposal in FP7 (see Letter.doc). Our
project, which is focused on fungal risk within patients with cystic fibrosis, has been selected
by the scientific office in France, and submitted to the European Community.
Moreover, biochemical studies needed for a better understanding of the pathogenesis of
fungal infections undoubtedly will be greatly facilitated by the knowledge of the genome of
our pathogens. Sequence of the genomes of Aspergillus fumigatus and Aspergillus terreus is
now available. So we would like to apply to a call for proposal from the National Agency for
Research (ANR- Call for proposal Pathogenomics) or from Genoscope for sequencing the
genome of one of the species within the Pseudallescheria boydi/Scedosporium apiospermum
complex.
Finally, we would like to organize in Angers the first meeting of our new working group. On
2009, the annual conference of the European Cystic Fibrosis Society will be held in Brest,
another city of Western France, and it may be interesting to organize our meeting in the
following days, to permit to some of us to attend also this important congress.
List of members of the ISHAM Working Group on Fungal infections in
cystic fibrosis
* Dr. Isabelle Accocéberry (UMR - CNRS 5162, Université Victor Ségalen Bordeaux 2, 146
rue Léo Saignat, 33076 Bordeaux Cedex. Phone: 33-(0)5-56 79 58 37; Télécopie : 33-(0)556 79 58 79; E-mail: isabelle.accoceberry@chu-bordeaux.fr) - Clinical surveillance,
biological diagnosis.
* Pr. Eliana Barreto-Bergter (Departamento de Microbiologia Geral, Instituto de
Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Avenida
Brigadeiro Trompowsky s/n, CCS Bloco I, 21941-590 Rio de Janeiro, Brazil. Phone: 5521-2562-6741; Fax: 55-21-2560-8344; E-mail: eliana.bergter@micro.ufrj.br) Physiopathology and treatment.
* Dr. Richard Barton (Mycology Reference Centre, Department of Microbiology, Leeds
General Infirmary, Leeds LS1 3EX, United Kingdom. Phone: 0113-39 23 390; Fax : 011334 35 649; E-mail: Richard.Barton@leedsth.nhs.uk) - Biological diagnosis, genotype
studies on Aspergillus.
* Samuel Bertrand (Substances d'Origine Naturelle et Analogues Structuraux, UPRES-EA
921, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, F-49045
Angers cedex, France. Phone: 33-2-41 22 66 74; Fax: 33-2-41 48 69 33; E-mail:
samuel.bertrand@univ-angers.fr) - Biological diagnosis, physiopathology and treatment.
* Pr. Alain Bonnin (UPRES-EA 562 - Laboratoire de Parasitologie-Mycologie, Laboratoire
de Microbiologie Médicale et Moléculaire, Hôpital du Bocage, BP 77908, 21079 Dijon
Cedex. Phone: 33-(0)3-80 29 36 03; Fax: 33-(0)3-80 29 32 80; E-mail: alain.bonnin@chudijon.fr) - Clinical surveillance, biological diagnosis.
* Dr. Jean-Philippe Bouchara (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA
3142, Laboratoire de Parasitologie-Mycologie, CHU, 4 rue Larrey, F-49933 Angers cedex
9, France. Phone: 33-2-41 35 34 72; Fax: 33-2-41 35 36 16; E-mail: JeanPhilippe.Bouchara@univ-angers.fr) - Clinical surveillance, biological diagnosis,
physiopathology and treatment, environmental studies.
* Pr. Alphonse Calenda (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA 3142,
UFR Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, F-49045 Angers
cedex, France. Phone: 33-2-41 22 67 22; E-mail: Alphonse.Calenda@univ-angers.fr) Physiopathology and treatment, environmental studies.
* Pr. Dominique Chabasse (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA
3142, Laboratoire de Parasitologie-Mycologie, CHU, 4 rue Larrey, F-49933 Angers cedex
9, France. Phone: 33-2-41 35 34 72; Fax: 33-2-41 35 36 16; E-mail: DoChabasse@chuangers.fr) - Clinical surveillance, biological diagnosis.
* Pr. Tsung Chain Chang (Department of Medical Laboratory Science and Biotechnology,
School of Medicine, National Cheng Kung University, 1 University Road, Tainan 701,
Taiwan, ROC. Phone: 886-6-2353535 ext. 5790 ; Fax: 886-6-2363956, E-mail:
tsungcha@mail.ncku.edu.tw) – Biological diagnosis.
* Dr. Sharon Chen (Centre for Infectious Diseases and Microbiology, Westmead Hospital,
Westmead NSW 2145, Australia. Phone: 61-2-9845 6255; Fax: 61-2-9893 8659; E-mail:
sharonc@icpmr.wsahs.nsw.gov.au) - Clinical surveillance, biological diagnosis,
physiopathology and treatment, environmental studies.
* Dr. Bernard Cimon (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA 3142,
Laboratoire de Parasitologie-Mycologie, CHU, 4 rue Larrey, F-49933 Angers cedex 9,
France. Phone: 33-2-41 35 34 72; Fax: 33-2-41 35 36 16; E-mail: BeCimon@chuangers.fr) – Clinical surveillance, biological diagnosis, environmental studies.
* Pr. Tom Coenye (Laboratorium voor Farmaceutische Microbiologie, Universiteit Gent,
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Harelbekestraat 72, 9000 Gent, Belgium. Phone: 32-(0)9-2648141; Fax: 32-(0)926458091; E-mail: tom.coenye@ugent.be) - Genotype studies.
Dr. Laurence Delhaes (Ecology of Parasitism, UPRES-EA 3609, Centre Hospitalier
Régional Universitaire de Lille, Laboratoire de Parasitologie-Mycologie, Hopital A.
Calmette, Boulevard du Pr. J. Leclercq, F-59037 Lille Cedex, France. Phone: 33-3-20 44
59 62; Fax : 33-3-20 44 42 64; E-mail: l-delhaes@chru-lille.fr) - Clinical surveillance,
biological diagnosis, physiopathology and treatment, environmental studies.
Pr. Loïc Favennec (Laboratoire de Parasitologie Mycologie, ADEN-EA3234, CHU
Charles Nicolle, 76031 Rouen. Phone: 33-(0)2-32 88 66 39; Fax: 33-(0)2-32 88 68 75; Email: Loic.Favennec@chu-rouen.fr) - Clinical surveillance, biological diagnosis.
Pr. Jean-Pierre Gangneux (Laboratoire de Parasitologie-Mycologie, Faculté de Médecine,
2 rue du Pr Léon Bernard, 35043 Rennes Cedex, France. Phone: 33-2-23 23 44 90; Fax:
33-2-23 23 46 29; E-mail: jean-pierre.gangneux@univ-rennes1.fr or jeanpierre.gangneux@chu-rennes.fr) – Clinical surveillance, biological diagnosis, treatment.
Dr. Sandrine Giraud (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA 3142,
Batiment Montéclair, CHU, 4 rue Larrey, F-49933 Angers cedex 9, France. Phone: 33-241 53 36 37; E-mail: Sandrine.giraud@univ-angers.fr) – Physiopathology and treatment.
Dr. Frédéric Grenouillet (Laboratoire de Parasitologie-Mycologie, CHU Jean Minjoz, F25030 Besançon Cedex, France. Phone: 33-3-81 66 91 64; Fax : 33-3-81 66 89 14; E-mail :
fgrenouillet@chu-besancon.fr) - Clinical surveillance, biological diagnosis.
Pr. Gerhard Haase (Institute of Medical Microbiology, University Hospital, RWTH
Aachen, Pauwelsstr. 30, 52074 Aachen, Germany. Phone: 49-241 8089515 or 49-241
8089510; Fax: 49-241 80 33 89515; E-mail: ghaase@ukaachen.de).
Pr. Vladimir Havlicek (Institute of Microbiology, Academy of Sciences of the Czech
Republic, Videnska 1083, 142 20 Prague 4, Czech Republic. Phone: 42-02-41062786; Fax:
42-02-41062749; E-mail: vlhavlic@biomed.cas.cz ; http://ms.biomed.cas.cz) - Biological
diagnosis, physiopathology and treatment.
Dr. Isabelle Joly-Durand (Ecology of Parasitism, UPRES-EA 3609, Centre Hospitalier de
Dunkerque, Service d’Hygiène Hospitalière et Département de Microbiologie, France.
Phone: 33-3-28 28 59 17; Fax : 33-3-28 28 54 41; E-mail: isabelle.joly@ch-dunkerque.fr) Clinical surveillance, biological diagnosis, physiopathology and treatment, environmental
studies.
Pr. Katrien Lagrou (University Hospital, Department of Microbiology, UZ Gasthuisberg,
Dienst Laboratoriumgeneeskunde, Herestraat 49, Leuven 3000, Belgium. Phone: 32-16-34
70 98; Fax: 32-16-34 79 31; E-mail: katrien.lagrou@uz.kuleuven.ac.be) - Clinical
surveillance, biological diagnosis.
Dr. Anne Landreau (Substances d'Origine Naturelle et Analogues Structuraux, UPRES-EA
921, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, F-49045
Angers cedex, France. Phone: 33-2-41 22 66 66; Fax: 33-2-41 48 69 33; E-mail:
anne.landreau@univ-angers.fr) - Physiopathology and treatment.
Dr. Gérald Larcher (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA 3142,
Laboratoire de Biochimie, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd
Daviers, F-49045 Angers cedex, France. Phone: 33-2-41 22 66 00 (or 67 41); Fax: 33-2-41
48 67 33; E-mail: Gerald.Larcher@univ-angers.fr) - Physiopathology and treatment,
environmental studies.
Dr. Victoria Maddox (Microbiology Department, Room G.18, Old Medical School, Leeds
General Infirmary, Great George St, Leeds LS1 3EX, United-Kingdom. Phone: 0113-3928664; E-mail: Victoria.Maddox@leedsth.nhs.uk) - Clinical surveillance, biological
diagnosis.
Dr. Graziana Manno (Laboratory for Cystic Fibrosis Microbiology, Department of
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Pediatrics, University of Genova, G. Gaslini Children's Hospital, Largo G. Gaslini 516147
Genova,
Italy.
Phone:
390105636290;
Fax:
390103773210;
E-mail:
graziana.manno@unige.it) - Clinical surveillance, biological diagnosis.
Pr. Kieren Marr, Director of the Tranplant Infectious Disease Program, Director of the
Infectious Disease Clinical Research Center (Division of Infectious Diseases, Oregon
Health and Science University, 3181 SW Sam Jackson Park Road, Mailcode L-457,
Portland, OR 97239. Phone: 503-418-1685; Fax: 503-494-4264; E-mail:
marrki@ohsu.edu) - Clinical surveillance.
Dr. Astrid Mayr (Department for Hygiene, Microbiology and Social Medicine, Hospital
Hygiene/Mycology, Schöpfstraße 41, Medical university of Innsbruck, A-6020 Innsbruck.
Phone: 43-(0)512-9003/70727; Fax: 43-(0)512-9003/73700; E-mail: astrid.mayr@imed.ac.at) – Clinical surveillance, biological diagnosis.
Pr. Wieland Meyer (Western Clinical School, University of Sydney, Molecular Mycology
Research Laboratory, Centre for Infectious Diseases and Microbiology, ICPMR, Level 3,
Room 3114A, Darcy Road, Westmead Hospital Westmead, NSW 2145, Australia. Phone:
61-2-9845 6895; Fax: 61-2-9891 5317, E-mail: w.meyer@usyd.edu.au) - Physiopathology
and treatment, genotype studies.
Dr. Sandrine Nail-Billaud (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA
3142, Laboratoire de Parasitologie-Mycologie, UFR Sciences Pharmaceutiques et
Ingénierie de la Santé, 16 Bd Daviers, F-49045 Angers cedex, France. Phone: 33-2-41 22
66 75; Fax: 33-2-41 22 37 33; E-mail: sandrine.nail@univ-angers.fr) - Biological
diagnosis.
Dr. Javier Pemán (Unidad de Micología, Servicio de Microbiología, Hospital Univ. La Fe,
Valencia. Phone: 34-96-197-3333; fax: 34-96-197-3177; E-mail: peman_jav@gva.es) Clinical surveillance, biological diagnosis, physiopathology and treatment.
Marc Pihet (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA 3142, Laboratoire
de Parasitologie-Mycologie, CHU, 4 rue Larrey, F-49933 Angers cedex 9, France. Phone:
33-2-41 35 34 72; Fax: 33-2-41 35 36 16; E-mail: mapihet@chu-angers.fr) - Clinical
surveillance, biological diagnosis, physiopathology and treatment, environmental studies.
Dr. Claudine Pinel (Département des Agents infectieux, Service de Parasitologie
Mycologie, CHU Albert Michallon, BP 217, 38053 Grenoble cedex 1. Phone: 33-(0)4-76
76 54 90; Fax: 33-(0)4-76 76 56 60; E-mail : CPinel@chu-grenoble.fr) – Clinical
surveillance, biological diagnosis.
Pr. Emmanuel Roilides (3rd Dept Pediatrics, University of Thessaloniki, Hippokration
Hospital, Konstantinoupoleos 49, GR-54642 Thessaloniki, Greece; Phone: +30-2310892444; Fax: +30-2310-992983; E-mail: roilidee@mail.nih.gov) - Clinical surveillance,
physiopathology and treatment, environmental studies.
Dr. André Luis Souza dos Santos (Universidade Federal do Rio de Janeiro – UFRJ, Centro
de Ciências da Saúde – CCS, Instituto de Microbiologia Prof. Paulo de Góes – IMPPG,
Departamento de Microbiologia Geral, Laboratório de Estudos Integrados em Bioquímica
Microbiana – Subsolo, Av. Brigadeiro Trompowsky, sem número, Rio de Janeiro, RJ
21941-590, Brasil. Phone: 55-21-25 62 67 40; E-mail: andre@micro.ufrj.br) Physiopathology.
Dr. Francoise Symoens (Scientific Institute of Public Health, Mycology Section, Juliette
Wytsmanstraat 14, B-1050 Brussels, Belgium. Phone: 32-2-642 56 30; Fax: 32-2-642 55
19; E-mail: f.symoens@iph.fgov.be) - Preservation of clinical and environmental isolates,
genotype studies.
Pr. Guy Tronchin (Groupe d'Etude des Interactions Hôte-Parasite, UPRES-EA 3142,
Laboratoire de Parasitologie-Mycologie, CHU, 4 rue Larrey, F-49933 Angers cedex 9,
France. Phone: 33-2-41 35 34 72; Fax: 33-2-41 35 36 16; E-mail: Guy.Tronchin@univangers.fr) - Physiopathology and treatment.
* Pr. Marianna Viviani (Laboratorio de Micologia Medica, Universitat degli Studi di
Milano, Via Francesco Sforza 35, I-20122 Milano, Italy. Phone: 39-2-503 20599 / 2-5503
3487; Fax: 39-2-503 20597; E-mail: marianna.viviani@unimi.it) - Clinical surveillance,
biological diagnosis, physiopathology and treatment.
* Dr. Adilia Warris (UMC St Radboud, Department of Pediatrics 836, P.O. Box 9101, 6500
Nijmegen, The Netherlands. Phone: 31-(0)2 43 614412; Fax: 31-(0)2 43 616428; E-mail:
a.warris@cukz.umcn.nl) - Clinical surveillance, biological diagnosis, physiopathology and
treatment.
* Dr. Nathan Wiederhold (Austin College of Pharmacy, University of Texas Health Science
Center San Antonio, 7703 Floyd Curl Dr. MSC 6220 San Antonio, TX 78229, USA.
Phone: 210-567-8340; E-mail: wiederholdn@uthscsa.edu) - Physiopathology and
treatment.