Write your name clearly and on all pages: Exam for the course “Introduction to Systems Neuroscience” (551-0657-00L) Version A Multiple choice: Indicate which answer(s) is(are) correct. 1. The receptive field (RF) of an individual rod is: O made of ON and OFF subregions O larger than that of a cone at the same retinal eccentricity O smaller than the RF of a ganglion cell O wavelength selective 2. The human retina O contains more cones than rods O contains mostly cells that do not have an axon O shows a higher concentration of cones with increasing visual periphery O is trichromatic 3. At very low light levels O cones are maximally stimulated O colors are not perceived O light intensity differences are not perceived O the central fovea is blind 4. Ganglion cells O are classified as simple or complex O have opponent center-surround organization O have overlapping receptive fields O have receptive fields that increase in size with visual eccentricity 5. The Lateral Geniculate Nucleus O is part of the thalamus O processes signals coming from the contralateral eye only O processes signals coming from the ipsilateral visual field only O contains cells with center-surround receptive fields 6. Visual cortex O is retinotopically organized O contains a disproportionally large representation of the fovea O contains orientation columns that each contain a set of ocular dominance columns O receives input signals from extrastriate cortex 1 Write your name clearly and on all pages: 7. Human V1 neurons O are almost all orientation selective O are never color selective O can be selective for the direction of motion O are almost always monocular 8. Extrastriate visual cortex O is organized into a “what” and a “why” pathways O contains numerous visual areas O occupies almost 50% of the human cortex O is primarily located in the frontal lobes 9. The cochlea O contains binaural neurons O is filled with air O performs a crude Fourier analysis of speech signals O is made of three distinct chambers 10. The basilar membrane O is thicker at its end than at its beginning O codes sound frequency by vibrating at different locations O codes sound amplitude by modulating its own vibration amplitude O codes sound frequency because of its own mechanical properties 11. Sound localization O works only with binaural cues O can be improved by moving own’s head O is partially computed within the brainstem O does not work for speech sounds 12. Primary auditory cortex O is located in the left hemisphere of right-handed people O receives inputs from the contralateral ear O contains neurons with a characteristic frequency O contains a somatotopic representation of the pinnae 13. The perceptual correlate of sound intensity is O pitch O timber O loudness O melody 2 Write your name clearly and on all pages: 14. The volley principle helps to code O sound frequency O sound intensity O sound phase O sound complexity 15. The ossicles in the middle ear O are useful for impedance matching between air and the inner ear O can have a protective role for the cochlea O are attached to the tympanic membrane O can be muscularly controlled 16. Speech sounds O are processed in several cortical areas O have frequencies at the high end of the human frequency response curve O contain multiple frequencies O are modulated by muscles under the control of primary motor cortex 17. Mechanoreception O is mediated by slow- and by fast-adapting receptors O is mediated by deep and superficial receptors O is mediated by free nerve ending O is most sensitive in hairy skin regions 18. Nociceptive signals O travel in pathways shared with temperature signals O become contralateral to their receptors at the level of the brain stem O reach the cortex via the thalamus O are carried by fibers with different conduction velocities 19. Somatosensory cortex O contains several motor homunculi O is densely connected with the frontal lobe O is organized into functional columns O contains multiple somatotopic representations 20. The temperature of food O is coded by free nerve endings in the mouth cavity O is relative to a particular adaptation point O is always higher in spicy food O is coded by signals in the trigeminal system 3 Write your name clearly and on all pages: 21. Lesions of the left somatosensory cortex O can affect texture discrimination specifically O can produce errors in right hand movements O always affect only one dermatome O cannot have any effect on proprioception 22. Receptive fields of somatosensory cortical neurons O can be orientation selective O can be direction selective O can be selective to three dimensional shape O can be selective to object curvature 23. Proprioception O is influenced by some cutaneous receptors O is influenced by joint receptors O is influenced by muscle spindles O is influenced by receptors in the muscle tendons 24. Striated muscles O are innervated by alpha and gamma motor neurons O are controlled by one motor unit each O are controlled by ipsilateral cortical areas O exert more force when more extrafusal fibers are stimulated 25. The neuromuscular junction O uses a neurotransmitter O produces a change in electrical potential in the innervated muscle fiber O shares many similarities with central nervous system synapses O contains receptors specific for particular substances 26. The sympathetic nervous system O is under the control of the hypothalamus O is targeting visceral organs only O is most active when the parasympathetic division is less active O can affect heart frequency 27. The parasympathetic nervous system O has more localized effects than the sympathetic division O uses short post-ganglionic fibers O doesn’t use any cranial nerve to carry its signals O blocks digestion when very active 4 Write your name clearly and on all pages: 28. The otholitic organs O contribute to our sense of position in space O contain hair cells O are connected with the semi-circular canals O are the main organs responsible for detecting head rotation along a vertical axis 29. The christae O contain liquid O respond inversely to the corresponding contralateral christae O are mostly useful to sense linear acceleration O are mostly useful to sense static position relative to vertical 30. Taste O can be decomposed into basic sensations O is mediated by signals travelling through the basal ganglia O results from activity in receptor cells sensitive to multiple compounds O is the perceptual correlate of food’s chemical composition 31. Olfactory cortex O projects to the thalamus O is organized into basic smell subregions O is much better at smell identification than smell discrimination O has an effect on the perceived flavor of food 32. Synesthesia O always involves vision and audition O is due to the action of pheromones O may be due to abnormal cortical connections O is occasionally experienced by the majority of the human population 33. The amygdala O is important for aversive conditioning O is made of a single, homogeneous nucleus O results in fearlessness when bilaterally lesioned O carries signals associated with innate fears 34. The limbic system O is the only system not involving any cortical area O contains structures involved in memory O is best known for its role in cognitive processing O produces signals that affect the parasympathetic nervous system 5 Write your name clearly and on all pages: 35. Limbic structures O are organized into a single connected loop O can indirectly affect the regulation of body water O contain the reward centers of the brain O contain the punishment centers of the brain 36. The hippocampus O is a unilateral structure O causes retrograde amnesia when bilaterally lesioned O contains synapses subject to long term potentiation O induces orality when lesioned in only one hemisphere 37. Hebbian learning O refers to a principle in which synaptic strength is determined by experience O is a theoretical concept lacking experimental evidence O could be linked to the appearance of new synapses O is independent of the timing of pre- and post-synaptic activity 38. Long term memory O can store only items that have been stored in short-term memory for several minutes O can be procedural, declarative or implicit O can result from classical conditioning O is affected in some forms of retrograde amnesia 39. The principle of equipotentiality refers to O the fact that all mammals have more or less equal procedural memories O the fact that all memories use the same amount of cortical tissue O the fact that practically all cortical locations can result in memory loss when lesioned O the fact that all limbic structures contribute equally to emotional memory 40. The basal ganglia O are involved in motor control O are part of the neocortex O are known to produce no visible symptoms when lesioned O are bilateral structures 6