How to Be A Doctor SHORT CASE For short case: findings; relevant +ive and –ives Differential – and things that back up likely diagnosis or go against it Markers of severity Complications LONG CASE History – 15-20mins Hello, this is exam; sorry for time restraints; you can tell me anything you know What is wrong? Why are you in hospital this time? Do you know your diagnosis? HPC Presenting symptoms Is there an action plan? What did the doctors do for you in ED? What did they do for you in the ward? What management and investigastions do the doctors have planned for you? What consultations have you had? What were the results of investigations? PMH List in order of importance; do you have a list of your medical problems? Active / non-active Generic details DH Immunisation status (influenza, hep A, hep B, Pneumococcus) Systems review – SOB, bowels etc… Do you have a list of medications? A SH Occupation, adequacy of income, current housing, ability to cope, mobility + steps Smoking, ETOH, drugs Hobbies (animals, chemicals, dusts), marital status, sexual problems and preference Immunisation Education and language Place of birth, overseas travel Level of Fx in community; level of help in community Involvement of ancillary: physio, SW, OT Psychological impact of disease FH Examination – be finished by 20-35mins What did examiners examine? Did they comment on signs? End Is there anything else I should know? Has anyone else asked you questions I haven’t asked? Did anyone else examine anything I didn’t? Presentation Intro: Is this management / diagnostic or investigative problem: demographics, patient issues, intro Mrs X is a 77 year old lady who lives with and is struggling to care for her unwell husband (social). She presented to the ED with the challenging investigative, management & resuscitation problem of shortness of breath and palpitations with likely cardio-respiratory failure (emergency problem). This is on a background history of cardiac failure, ischaemic heart disease, ventricular tachycardia, mitral valve replacement, non compliance with her medications (contributing RF’s) including warfarin, recent dental procedures, renal impairment, smoking & possible bronchospasm. HPC: Presenting problem – much detail; relevant history; relevant +ives and –ives; Type of presentation; date; current GP, specialist and ward Systems review Active problems – some detail Active problems that are not relevant to current presentation Non-active problems DH + A – reference what medication is used for FH SH – include non-clinical issues Examination cardinal signs and other signs; general appearance; vital signs; most important system first; relevant +ives and ives PMH Summary statement In conclusion; Mrs X (demographics) is now recovering from cardio-respiratory failure 2 weeks post admission. It seems likely that this was due acute pulmonary oedema (key issues). Contributing factors are multi-factorial but likely include ischaemic heart disease, AMI, occluded coronary artery bypass grafts, renal impairment and arrhythmias. Further investigations would be required to determine the severity of these factors and to determine other contributing factors. Optimal medical management is required as well as considering her suitability or non-suitability for more invasive future management. Mrs X may struggle to live independently and this has implications for her husband who has been largely dependent on her. Differential diagnosis and findings that support / refute – with relevant weightings What would you do if this patient came into ED? Or may need to postulate on possible presentations of this patient to the ED Investigations and justification for (beside, lab, imaging) – comment on results if given Management and management goals – inc supportive care, disposition etc… Primary ED points in this case are CV History IHD RF’s Complications Trt IHD, incr lipids, DM, HTN, +ive FH, smoking, OCP, premature menopause, obesity, physical inactivity, long term NSAIDs, erectile dysfunction Arrhythmia, CCF, angina, emboli; OT Angioplasty / thrombolysis / CABG (number of grafts; drug eluting stent?) Anticoagulants and how long Rehab program; RF control IE Symptoms Malaise, fever, anaemia Cause / RF’s Recent dental / endoscopic / OT RF, congenital heart disease, valve lesions, heart OT, IVDU, immune suppression Trt Embolic: CVA, loin pain Antibiotic prophylaxis (constant – for RF; before procedure – IE) A if prev IE, prosthetic heart valve, congenital heart malformation (unrepaired cyanotic heart disease, residual defect, recent OT), cardiac transplant with valve disease --> dental procedure, oral surgery ?valve replacement discussed Abx allergy OE Clubbing, splinter haem (also vasculitis, RA, PAN, haematological malignancy, trauma), Osler’s Complications nodes (finger, painful), Janeway lesions (palms and pulps, non-tender); Source of infection; Roth’s spots, conjunctival petechiae; dentition; Regurg/stenosis; prosthetic valve; PDA; VSD; coarctation of aorta; Signs of CCF CCF Symptoms Precipitant (arrhythmia, med change, MI, anaemia, infection, thyrotoxicosis, OT, PE, salt intake, Cause NSAIDs, XS exertion, pregnancy) As above For cardiomyopathy: ETOH, FH of same, haemachromatosis HTN, IHD, RF, valve disease, congenital heart disease, cardiomyopathy, prev cardiac OT Precipitant; Postural BP (?beta-B, ACEi) RF’s PMH OE HTN Symptoms Cause Risk factors Complications Trt OE Arrhythmia SOB, PND, orthopnoea, oedema, ascites, nausea; chest pain Classify by NYHA Measurements Endocrine, phaemochrom Sx; RAS; coarctation of aorta, adrenal Ca DM, lipids; ETOH, exercise, salt intake, smoking CVA, CCF, PVD, renal failure SE’s of trt Fundi (silver wiring, AV nipping, flame haemorrhages, cotton wool spots, hard exudates, Papilloedema); LVF; coarctation Symptoms RF’s SH FH Trt Palpitations, effect of Valsalva, syncope; persistency IHD, AS, cardiac OT, congenital heart disease, thyrotoxicosis, WPW, recent ETOH binge, PE, HTN RF for embolic events (prev emboli, MV disease, CCF, HTN, DM, thyroid) Ability to manage multiple blood tests and trips to lab Sudden cardiac death (long QT, Brugada, HOCM) IV/PO? manouvres? shock? SE’s of trt? Ablation? AICD? Recent INR’s + Warfarin doses Generic details Immunisation status (influenza, hep A, hep B, Pneumococcus) Compliance with meds Examination What did examiners examine? Did they comment on signs? Stand back and look Sit patient at 45 degrees and expose neck and chest General Temperature chart; ?IV cannula; ?infusion running Syndromes Marfan’s, Turner’s, Downs, Cushings, acromegaly General Uraemia, SOB, cyanosis CCF Precipitating factor Oedema Nutrition, myxoedema Put hands on thighs in front of them Hand Pulse (rate, rhythm – NOT CHARACTER); radio-radial; clubbing; peri cyanosis Pemberton’s sign HOCM AR Hyperlipid SVC obstr Clubbing = RS CV GI - Jerky / sharp pulse Collapsing pulse; Quincke’s sign Tendon xanthomata Arm oedema Lung Ca, bronchiectasis, lung abscess, empyema, pul fibrosis, asbestosis, CF, mesothelioma IE, cyanotic congenital heart disease IBD, cirrhosis, coeliac Thyrotoxicosis, familial, pregnancy, 2Y hyperPT Take BP: (boths arms, lying and standing if HTN; legs if young and HTN) – estimate SBP via radial pulse Face Xanthelasma; petetchiae; cyanosis; scleral pallor; Argyl-Robertson pupil (AR) MS Malar flush Valve Jaundice (haemolysis) Marfan’s Arched palate SVC obst Plethoric cyanosed face, periorbital oedema, exopthalmos, conjuctival injection, Horner’s syndrome, fundi for venous dilation Neck JVP Carotids SVC obstr Chest Inspection Palpation Auscultate Height, character, change with respiration; do hepatojugular reflex (15 secs in epigastrium – ?sustained) Dominant a wave = atrial contraction: TS, PS, pul HTN (eg. 2Y to MS), HOCM Dominant v wave = atrial filling: TR Cannon a wave: CHB, nodal tachycardia, VT, pacemaker Elevation: RVF, TS, TR, pericardial effusion, constrictive pericarditis, SVC obstruction, fluid overload, hyperdynamic circulation (eg. Fever, thyrotoxicosis) Character; carotid bruit AS Slow rising AR Corrigan’s = prominent, water hammer Raised non-pulsatile JVP; ?large thyroid gland; LN’s; stridor Scars, deformity, visible pulsations, pacemaker Apex beat (position in ICS, mid clavicular line, character) Pressure loaded = forceful + sustained = AS, HTN Volume loaded = forceful + unsustained = AR, MR Tapping = MS Double / triple = HOCM Absent = constrictive pericarditis Thrills: across L side chest horizontally = palpable murmur = AS, MS, VSD Parasternal impulse: L sternal edge vertically RV Heave = RVH, LA enlargement = MR Bell + diaphragm at apex Diaphragm at lower and upper L sternal edge, R upper sternal edge If murmur, time with carotid pulse Listen below L clavicle for PDA murmur L lateral position: rpt apex and bell in mitral area (for MS) Sitting forward in expiration: rpt thrill, listen lower L sternal edge with diaphragm; ?AR If ?HOCM (ie. Pure systolic murmur) – Valsalva, resp phases, hand grip, standing, squatting at lower left sternal edge with diaphragm S1 S2 Loud MS, TS Hyperdynamic Soft MR 1st deg HB, LBBB Loud AS HTN Soft AR, PS AV closes then PV usually on inspiration = physiological splitting Wide = Incr splitting on inspiration PS, MR, VSD, RBBB Fixed splitting ASD Reversed AS, CoA, PDA, LBBB S3 S4 Rapid diastolic filling = AR, MR, VSD, PDA, failure, constrictive pericarditis High atrial pressure = AS, PS, MR, HTN, HOCM, IHD Systolic Diastolic Continuous HOCM SVC obstr Early MR, TR VSD Mid AS, PS ASD, HOCM Late MVP HOCM Pan MR, TR VSD, AP shunt Early AR, PR Mid MS, TS, AR RF, Austin Flint of AR, atrial myxoma Late MS, TS Atrial myxoma PDA, AV fistula, venous hum, AP connection, mammary souffle Ejection and pan-systolic murmur Louder with Valsalva, standing, jogging Softer with squatting, raising legs, forceful handgrip Distended collaterals patient is now sitting up Back Inspection Palpation Auscultate Scars, deformity, oedema Percuss for pleural effusion ?LVF – crackles lie flat Abdo Lie flat with 1 pillow Inspection Palpation Radio-femoral (if PMH of HTN) Liver (megaly = RVF, constrictive pericarditis; pulsatile = TR), spleen if ?IE (megaly = IE, constrictive pericarditis), aorta, femoral arteries; renal mass (HTN) Auscultate Femoral arteries; renal bruit (in HTN; R+L above umbilicus; over flanks) Oedema Ascites; collaterals; liver Legs Cyanosis, cold, trophic changes, ulceration, peri pulses (dorsalis pedis, post tibial), oedema, calf tenderness; varicose veins Oedema Inguinal nodes; delayed ankle jerk (hypothyroid) Neuro IE FND; fundi Presentation Intro, summary Differential diagnosis Findings that support / refute diagnosis; always tailor to specific patient IE Atrial myxoma, occult malignant neoplasm, SLE, PAN, post-strep GN, PUA, cardiac thrombus Incr trop Thrombus Infection Trauma Tox Other cardiac Non cardiac MI Myocarditis Cardiac contusion, cardioversion, biopsy; cardiac OT; stent; angioplasy Cardiotoxic; Irukandji syndrome CCF; aortic dissection; HOCM; AS; AR; arrhythmia; cardiomyopathy; rhabdo Sepsis; renal failure; PE; pul HTN; burns; exertion; CVA; SAH Investigations Ask for 1-2 recent investigations and reason for ordering Comment on results, even normal Bedside Lab Imagin Echo (vegetations; valve S/R; RWMA; LVEF); ECG; Temp chart Trops; Na, K, Ur, Cr, BNP, Hb; TFT IE: cultures (3-6x over 24hrs; strep viridans, strep faecalis, strep bovis, staph epidermidis, HACEK, fungi); FBC, ESR, serology (immune complexes, C3, C4, RF, ANA); urine; Haematuria, proteinuria, RBC casts HTN: ?cushings ETT, stress echo, angiogram; CXR; RV biopsy; renal angio in HTN; Holter Management Suggest management and set management goals IE Benpen 6-12g OD for 4-6/52 Valve replacement: if resistant, mod-severe failure, persistent +ive blood culture, conduction disturbance CCF Remove cause Inotropes (dobutamine, dopamine, Levosimendan) Implantable defib if malignant rhythm / severe Decr activity; diuretics; low salt diet; fluid restriction; daily weighs; ACEi / AR blocker, beta-blockers, digoxin HTN Remove cause Lifestyle factors (weight, exercise, ETOH, salt) Meds Arrhythmia Drugs; pacing; AICD; rate vs rhythm control; AVN ablation; DC cardioversion CHADS2 RS History HPC Bronchiectasis Symptoms PMH DH Mng OE Ix Lung Ca Clubbing; Large vol purulent sputum; Coarse crackles; Pneumonia, pleurisy, empyema, lung abscess; Signs of R heart failure, cor pulmonale Bloods Ig levels; ABG Other Sputum results; PFT’s (restrictive/obstructive); cilliary Fx; sweat test; bronchogram Imaging CXR (cystic lesions, thick bronchial walls, streaky infiltration), CT scan Symptoms Cause Haemoptysis, SOB, wheeze, sinusitis, recurrent pneumonia, weight loss, fever, anorexia, CCF); When began Childhood pertussis, measles; LRTI; flu; CF, TB, HIV, 1Y cilliary akinesia, aspergillosis RA, Sjogren’s syndrome Abx; bronchoD Physio, postural drainage, lung resection Haemoptysis, cough, SOB, chest pain, systemic Sx) How diagnosed? Metastatic symptoms (rib, nerve involvement, SVC obstruction, dysphagia, lymphangitis, lymph nodes, bone, brain) Smoking, occupation SH OE No of dependents Haemoptysis, Weight loss, cachexia, fever, gynaecomastia, opportunistic infections; Clubbing; lower brachial plexus inj weak finger abduction; hypertrophic pulmonary osteoarthropathy; Ptosis and constricted pupils (Horner’s); SVC Ix COPD obstruction; Fixed insp wheeze; Pleural / pericardial effusion, tracheal obstruction; Oesophageal obstruction, hepatomegaly; Lymphangitis, cervical adenopathy, dermatomyocytis, thrombophlebitis, acanthosis nigricans, scleroderma, purpura; Pancoast tumour, RLN palsy, diaphragmatic paralysis, FND, Eaton Lambert’s, peri/autonomic neuropathy, SACD Bloods Incr Ca (PTH), decr Na (ADH), ACTH, glu; FBC; LFT Other Sputum cytology; PFT’s biopsy / FNA; bronchial brushings / washings; pleural biopsy; staging Imaging CXR (hemidiaphragm changes; peri = adenoCa; central = squamaous; hilar = small cell; infiltrate = bronchoalveolar); CT; bronchoscopy; Symptoms Precipitants DH SH FH SOB, cough, sputum, wheeze, exercise tolerance, wegith loss URTI, pneumonia, meds, RVF, smoking, aspiration, GORD; Smoking (age started, how many) Steroids, bronchoD; home O2 Occupation (air pollution, plastics factory toluene) Alpha-1 AT OE Look at sputum; cachexia; SE of trt (eg. tremor in salbutamol, steroids); Early coarse insp creps; Pursed lip; exp time; WOB Ix Bloods Other Imaging ILD Symptoms PMH DH SH OE Ix DD Sarcoidosis ABG; Hb (polycythaemia); alpha-1 AT; albumin; Ca, phos PEFR; PFT’s (decr FEV1/FVC; 15% incr with bronchoD); sputum culture; BMI; ECG (RVH, multifocal atrial tachy) CXR (hyperinflation, cor pulmonale, pneumoniae, bullae); CT; SOB, cough, lethargy, malaise, fever, rash, arthralgia, haemoptysis; Onset and duration Scleroderma, SLE, Sjogren’s, RA, sarcoidosis, asthma, Churg Strauss, Goodpasture’s, PAN; Prev radiotherapy, aspiration pneumonia, miliary TB Amiodarone, hydralazine, procainamide; Methotrexate, penicillamine, bleomycin, cyclophosphamide; Nitrofurantoin, bromocriptine Mineral dust (silicosis, asbestosis, coal), chemicals (NO2, Cl, NH3), birds, farmer, flax, hemp dust Clubbing; Ant uveitis; Fine dry late/pan insp creps; Cyanosis; upper vs lower; Erythema nodosum; signs of steroid SE’s Bloods ABG; ESR; LDH; eosinophilia; serology for CT diseases Other PFT’s (restrictive usually); Bronchoalveolar lavage; biopsy Imaging CXR; CT Idiopathic interstitial pneumonia, CT disease (eg. see above), GVHD, Crohn’s, 1Y biliary cirrhosis, occupational, radiation, aspiration pneumonia, drugs (see above), gases, hypersensitivity Symptoms DH Fever, weight loss, malaise, cough, SOB, arthralgia, blurred vision, eye pain, tearing Steroids, NSAIDs, cyclosporins, cyclophosphamide OE Ant uveitis, yellow conjunctival nodules, papilloedema; basal end-insp crackles; RV failure, cardiomyopathy, arrhythmia, pacemaker, AICD; Ix Bloods Hepatomegaly, splenomegaly; Erythema nodosum, lymphadenopathy, parotid enlargement, plaques, rash (erythematous spots with waxy flat top), subC nodules, lupus pernio on face (purple shiny swollen nodules); facial nerve palsy FBC (decr WCC, incr eosinophils); incr ESR; ACE; ABG PFT’s (decr lung vol, normal FEV1/FVC); LN biopsy; ECG (CHB, V arrhythmias); lung/LN biopsy Imaging CXR (hilar lymphadenopathy, pul infiltration, paratracheal lymphadenopathy, reticulonodular changes, cavitation, pleural effusion, linear atelectasis); CT chest; bronchoscopy and biopsy TB, histoplasmosis Other DD CF Symptoms SH Mng OE Ix Pul HTN PMH OE Ix TB OE Ix Examination Clubbing; Conditioning; BMI; Quality of cough; examine sputum; chest wall Development; fecal loading Bloods FBC (AOCD or malabsorption; WCC); U+E; LFT; ADEK def Other Sputum culture; PFT’s; sweat test Imaging CXR (compare with prev films; incr lung markings; cystic changes; mucus plugs; atelectasis; pneumoT); CT Collagen vascular disease, shunts, portal HTN, HIV, splenectomy, myeloproliferative disorders, L heart disease, COPD, ILD, thromboembolic obstruction, scleroderma, congenital heart disease DVT; RV heave; palpable P2; TR Bloods ABG Other PFT’s Imaging CXR (RV dilation, large prox pul arts); ECG (R heart strain, hypertrophy), CT angiogram, VQ scan, echo; R heart catheterisation Symptoms PMH SH Mng Generic details Age of diagnosis; presenting Sx (eg. recurrent LRTI, FTT); cough, sputum, haemoptysis, wheeze, SOB, nasal polyps, sinusitis, weight loss, diarrhoea, steatorrhoea, constipation, bowel obstruction, abdo distension; occasionally biliary cirrhosis --> portal HTN --> jaundice, varices; DM; rectal prolapse No. prev hospital admits Support network; understanding of inheritance Physio, antibiotics, bronchoD, pancreatic enzyme Weight loss, sweats, fever, cough, chest pain; Time of diagnosis Malnutrition, alcoholism, HIV, DM Recent immigration; Social effects of disease; continue work? do friends know diagnosis? does occupation present public health risk? screening of friends/family? family members treated? Meds, how long for, supervised / unsupervised, SE’s (hepatitis, ototoxicity, optic neuritis, peri neuropathy, diarrhoea) Conditioning; LN’s; 1Y: pleural effusion, empyema, lobar collapse; 2Y: upper lobe crackles, wheeze; Pericarditis, tamponade; Loin tenderness, abdo nass Bloods rpo gene if resistant; PCR for rapid; tuberculin testing; fasting BSL (for DM) Other Sputum (3 samples on separate days), Ziehl-Neelsen; LN biopsy; bronchial washings; sensitivities; Mantoux (5mm high risk, 15mm low risk) Imaging CXR (infiltrates, cavities (2Y); focal shadowing and enlarged LN’s = 1Y Ghon complex; may be normal if HIV) Immunisation status (influenza, hep A, hep B, Pneumococcus) Undress to waist and sit up in bed – watch for SOB Ask to see sputum and temp chart General Sputum; SOB at rest; RR; WOB; cachexia; ask to cough (loose, dry, bovine (RLN inj)); PEFR; FET (abnormal if >3secs); audible wheeze; breathing pattern Put hands out in front to look for flap Hands Clubbing = RS Lung Ca, bronchiectasis, CF Lung abscess, empyema, pul fibrosis, asbestosis, mesothelioma CV IE, cyanotic heart disease GI IBD, cirrhosis, coeliac thyrotoxicosis, familial, pregnancy, 2Y hyperPT Peri cyanosis; nicotine staining; anaemia; small muscle wasting (weak finger abduction = lower brahcial plexus inj from lung Ca); wrist tenderness (hypertrophic pulmonary osteoarthropathy); pulse (pulsus paradoxicus); flapping tremor Face Ptosis and constricted pupils (Horner’s); central cyanosis; press maxillary sinus and percuss frontal sinus; say a few words if voice sounds hoarse Neck Position of trachea (deviation suggests upper lobe abnormality); tracheal tug; LN’s Sit up with legs over side of bed to examine back Back Inspection Palpation Percussion Auscultate CCF Sit back in bed Kyphoscoliosis; ank spond (assoc with fibrosis); scars; prominent veins; radiotherapy skin Changes; needle marks from prev aspirations Expansion (upper = look at clavicles from behind to ensure moving; and lower – aim 5cm separation) Inc supraclavicular BS (bronchial / vesicular; normal / decr; crackles, wheeze; early/mid/late/pan; insp/exp) Vocal resonance (say 99) Medium late/pan insp creps Chest Inspection Palpate Percussion Auscultate Chest deformity; symmetry of movement; distended veins; radiotherapy and radiotherapy marks; scars Supraclavicular, axillary LN; apex beat; chest expansion; palpate breasts Clavicles directly, then lower In high axillae also JVP Pul HTN Abdomen Inspection Palpate Signs of liver failure Legs Peri oedema Lie to 45 deg Incr JVP; large V wave on JVP Lie flat Investigations Pleural fluid analysis CXR, plus ask to see lateral End Is there anything else I should know? Presentation Draft intro statement Differential diagnosis Findings that support / refute diagnosis Pul fibrosis Upper lobe Toxin Infection Infiltrative Rheum Silicosis, coal worker’s pneumoconiosis, radiation TB; CF; aspergillosis; PCP Sarcoidosis, histiocytosis, aspergillosis; eosinophilic Ank spond Lower lobe Toxin Infective Asbestosis, hydralazine, amiodarone, bleomycin Bronchiectasis, aspiration Infiltrative Rheum Large hilum LN Vessel Cryptogenic fibrosis alveolitis RA, scleroderma Lymphadenopathy; Ca Pul venous HTN (upper half hilum; LVF, MS, MR) Pul artery HTN (1Y pul HTN, lung disease) Incr pul blood flow (LR shunt, hyperdynamic circulation) Focal consolidation Infective Vascular Ca Pneumonia; Atelectasis Pul infarction; intrapul haemorrhage Alveolar cell carcinoma Diffuse airspace disease Infective Vascular Ca Autoimmune Pneumonia (mycoplasma, pneumocystis); interstitial pneumonitis Pul oedema; contusion; PE Alveolar cell Ca; lymphoma Goodpasture’s; alveolar proteinosis Fine reticular = ILD Vascular Infective Ca Autoimmune Coarse reticular Reticulonodular Miliary nodular (2-3mm) Nodular (>3cm) Pul oedema Interstitial pneumonitis (mycoplasma, viral); atypical pneumonia Lymphangitis metasasis Sarcoidosis; histicytosis; SLE; RA; scleroderma; polymyositis; hypersensitivity pneumonitis; eosinophilic granuloma; collagen vascular disease; fibrosing alveolitis Toxin Inhalation injury; asbestosis, silicosis, farmer’s lung, coal, methotrexate, amiodarone End-stage pul fibrosis As per reticular TB, fungal, nocardia, varciella, silicosis, coal worker’s pneumoconiosis, sarcoidosis, eosinophilic granuloma, neoplastic Mets; lymphoma; benign tumours; fungal; parasitic; septic emboli; RA; Wegener’s Granulomatosis Cavitating lesions Infective Vascular Ca Autoimmune Other Staph aureus, klebsiella, anaerobes, aspiration, G-ives, TB, fungal (aspergillosis, cryptococcal) Septic emboli; pul infarct SCC, Hodgkin’s Granulomatosis; sarcoid; Wegener’s; RA Management Suggest management and set management goals Bronchiectasis Abx; bronchoD; inhaled steroids; postural drainage; pred; vaccines; trt of CCF; Ig if Ig def; embolisation if massive haemoptysis; smoking cessation; OT if localised disease; transplant if end stage Lung Ca OT (if non-small cell); radiotherapy; maybe chemo COPD Nicotine replacement; Abx; bronchoD; inhaled steroids; vaccine; steroids; pul rehab; home O2; trt CCF; BiPAP ILD Remove exposure; steroids; maybe immunosuppression (cyclophosphamide, colchicine); vaccines; home O2; lung transplant Sarcoidosis Prednisone; if longer term, Methotrexate, Azathioprine; infliximab CF Physio; Abx; bronchoD; pancreatic enzymes; lung transplant TB Isoniazid, Rifampicin, ethambutol, pyrazinamide; IREP initially until sensitivies available --> IRP for 2/12 --> IR 4/12; may need to be supervised; repeat sputum cultures until become negative; resistant if +ive after 3/12 GI History HPC PUD Symptoms Pain, relief, recurrences, GI bleed; Weight loss, recurrent vomiting PMH DH FH OE DD Malabsorption Symptoms PMH DH FH OE DD IBD Dyspepsia; DM; thyroid; hyperPT; CT disease; prev ulcer OT Digoxin, KCl, PO Abx, NSAIDs, ETOH; PPI; H pylori trt; steroids; anticoagulants Of same (?MEN I) Anaemia; Epigastric tenderness; scar; melaena; abdo mass (?Ca) GORD, gastric Ca, biliary pain, pancreatitis, pancreatic Ca, chronic mesenteric ischaemia; varices; Mallory-Weiss tear; erosions; angiodysplasia Pale, bulky offensive stools; weight loss; weakness (K def); anaemia (Fe def); bone pain (osteomalacia); glossitis and angular stomatitis (Vit B def); bruising (Vit K def); oedema (protein def); peri neuropathy (vit B def); eczema, dermatitis herpetiformis; amenorrohoea (protein def)); time of onset and duration Cause: gastrectomy, prev bowel OT, liver / pancreatic disease, Crohn’s disease, prev radiotherapy, DM, HIV ETOH, neomycin Coeliac disease, IBD Weight, conditioning; Clubbing; Bruising, dermatitis herpetiformis, erythema nodosum, pyoderma gangrenosum, stomatitis, pigmentation, perianal lesions, anaemia; Scars, chronic liver disease signs Coeliac disease, tropical sprue, giardiasis, lymphoma, Whipple’s disease, IBD, chronic pancreatitis, CF, biliary obstruction, chronic liver disease, bacterial overgrowth, SI ischaemia, SI resection, HIV Symptoms Reason for admission, number of hospital admissions; Current symptoms UC – bloody diarrhoea, malaise, fever, weight loss CD – pain, diarrhoea, weight loss, malabsorption, intestinal obstruction Complications Toxic megacolon, perf, haemorrhage, strictures, fistula, anorectal disease, abscess, obstruction, perf, gallstones, Ca, liver disease (fatty liver, 1Y sclerosing cholangitis, cirrhosis, cholangiocarcinoma, amyloidosis); anaemia; Fe def; thromboembolism; arthropathy; ank spond; erythema nodosum; pyoderma gangrenosum; apthous ulcers; uveitis / conjunctivitis / episcleritis, renal stones, osteomalacia DH NSAIDs, retinoic acid, OCP SH Sexual preference (proctitis is DD); smoking (protective in UC); domestic arrangements and employment FH Of same, bowel Ca OE DD Nutrition, hydration; signs of Cushing syndrome; Clubbing; Lesions, anaemia; Uveitis; Tenderness; abdo masses; anal lesions; signs of liver disease Pseudomembranous colitis, radiation, ischaemic colitis, diversion colitis, toxic exposure, lymphocytic colitis Colon Ca Symptoms Change in bowel habit, PR bleeding, anaemia, AP, constipation, vomiting; bladder Sx from invasion; neuro pain from sacral plexus Complications Proctitis, cystitis PMH Polyps; IBD; Peutz-Jehger’s syndrome; DM; acromegaly SH Determine if understands diagnosis; social support network FH FAP (if present ask if children have been screened); ovarian / endometrial Ca OE Changes of radiotherapy, pigmentation of Peutz-Jehger’s; Abdo masses, scars, PR CLD Symptoms Jaundice, ascites, AP, bleeding, encephalopathy, weakness Complications Encephalopathy, portal HTN, ascites, varices, erectile dysfunction PMH Hepatitis, jaundice, prev transfusions, DM, CCF, haemachromatosis; hepatitis status; Wilson’s disease; For NASH – obesity, type II DM, incr lipids DH Methyldopa, isoniazid, nitrofurantoin SH ETOH intake, drug addiction, sexual orientation, tattoos, overseas travel OE Racial origin; Clubbing; Tattoos; scratch marks; xanthelasma; collaterals; hair loss; spider naevi; Kayser Fleishcer rings (Wilson); bilat VI nerve palsy (Wernickes); CCF; TR; constrictive pericarditis; Signs of chronic liver disease / portal HTN; splenomegaly; ascites; oedema; melaena; liver bruit; abdo mass ETOH; Hep B/C; NASH; drugs (methyldopa, chlorprom, isoniazid, nitrofurantoin, Methotrexate, amiodarone), autoimmune; haemachromatotis; Wilson’s disease; 1Y sclerosing cholangitis; 1Y/2Y biliary cirrhosis; alpha-1 AT def; CF; Budd-Chiari syndrome; CCF; constrictive pericarditis; idiopathic DD Generic details Immunisation status (influenza, hep A, hep B, Pneumococcus) Investigations PUD IBD Colon Ca CLD Endoscopy, barium meal, H pylori (serology / biopsy) Follow up colonscopies Staging results; surveillance colonoscopy Liver biopsy Management PUD Malabsorption IBD Colon Ca CLD Blood transfusion, injection in peptic ulcer base, surgical oversewing Diet, pancreatic supplements, Vit supplements, cholestyramine, Abx Sulfasalazine, mesalazine, olsalazine, steroids, metronidazole, Azathioprine, infliximab Radiotherapy Protein restriction, fluid restriction, ETOH abstinence, steroids, Lactulose, neomycin, TIPS procedure Examination What did examiners examine? Did they comment on signs? General Jaundice, pigmentation (haemochromatosis), xanthomata (1Y biliary cirrhosis), mental state (encephalopathy); wasting, cachexia; drowsiness; temperature Hands Clubbing (IBD, cirrhosis, coeliac), leuconychia, palmar erythema, Dupuytren’s contractures, Arthropathy (haemachromatosis), hepatic flap (30secs) Arms Spider naevi, bruising, wasting, scratch marks (chronic cholestasis); ask for BP Face Sclera, jaundice (colon Ca, CLD), anaemia (PUD, colon Ca), iritis; parotids (ETOH); fetor hepaticus; stomatitis, leukoplakia, ulceration, gingivitis, bleeding, atrophic glossitis; pigmentation Sit up Neck From behind; LN’s (colon Ca, malabsorption) Swing legs over side of bed Axilla Axillary LN’s Sit back down on bed Chest Inspection Palpate Auscultate Gynaecomastia, spider naevi Breasts if think intra-abdo Ca For pleural effusions / creps; HS for TR if pulsatile liver felt Lie flat with 1 pillow, exposure abdo Abdomen Inspection Palpation Percussion Auscultate From foot of bed, from side; masses, scars, distension, prominent veins, striae, bruising, Pigmentation; visible peristalsis; spider naevi Take deep breaths and observe from side to look for moving liver Ask if tender; light then deep palpation; liver, spleen; roll on R and palpate spleen again if not Palpable; kidneys Percuss liver / spleen size; estimate span with tape measure Spleen: no palpable upper border; has notch; move inferomedially with respiration; no resonance over splenic mass; not bimanually palpable; friction rub commonly he If spleen not palpable lying flat, roll to R and try again RIF mass: appendix abscess, caecal Ca, CD, pelvic kidney, ovarian Ca/cyst, carcinoid, psoas abscess, ileocecal TB LIF mass: faeces, colon Ca, diverticular disease, ovarian Ca/cyst, psoas abscess Upper abdo mass: lymphadenopathy, AAA, stomach Ca, pancreatic Ca/cyst, PS, colon Ca Percuss for ascites; roll towards you if not resonant to flanks, to check for shifting dullness Liver, spleen and renal areas Bruits (hepatocellular Ca, alcoholic hepatitis) Rubs (Ca, recent liver biopsy, infarct, gonococcal perihepatitis) Venous hum (portal HTN) Bowel sounds Groin Genitalia, LN’s, hernial orifices (standing and coughing – say that you would do this) Ask if you can palpate testes PR Say you would do; inspect (fistulae, tags), palpable (masses, blood) Legs Bruising, oedema Neuro: peri neuropathy; prox myopathy; cerebellar syndrome Sit up 45 deg JVP Investigations Urine PUD Bloods Other Imaging Malabsorption Bloods Other Imaging IBD Bloods Other If atypical, fasting serum gastrin, gastric juice pH, secretin test; incr Ca ?MEN I Endoscopy (?active bleeding or clean ulcer base); biopsy result USS (biliary tract); CT (pancreas, ZES) Fe, long PT, low Ca, low chol, low carotene, +ive Sudan stain of stool for fat; faecal fat estimation; glucose / Lactulose breath hydrogen test for bacterial overgrowth; Schilling test for ileal disease; FBC (?anaemia); Fe, Ferritin, folate, Vit B12, alb, Vit D level, Ca, Phos, ALP, INR Gastroscopy, SI biopsy (subtotal villous atrophy); histology; parasites AXR (Crohn’s disease, diverticula, blind loops) FBC (anaemia, WBC); ESR, CRP; LFT; U+E; alb; p-ANCA, ASCA (in CD) Stool spec (amoebiasis, Shigella, Salmonella, Yersinia, Campylobacter, E coli, C diff, lymphogranuloma venereum, gonorrhoea, syphilis; if immunocomp – herpes, CMV, cryptosporidium); TB; sigmoidoscopy and biopsy; Ba enema (loss of haustrations, muscosal Imaging irregularity and ulcers, spasm, pseudopolyps, bowel shortening, extent of involvement, strictures, Ca, thickening, cobblestoning, skip lesions, fistulas); colonoscopy (granulomas, mucus) and biopsy AXR (bowel wall thickening, gaseous distension, toxic megacolon) Colon Ca Bloods Other Imaging Genetic screening (if +ive FH); LFT; CEA Colonoscopy, Ba enema, FOB testing Staging; CXR for mets CLD Bloods LFT; alb; INR; FBC (anaemia, film, macrocytes, decr plt, decr WBC); Fe; folate; U+E (decr Na); hepatitis serology; AMA (1Y biliary cirrhosis); ANA, ASMA (autoimmune hepatitis); p-ANCA (UC + 1Y sclerosing cholangitis); AFP (liver Ca) Ascitic tap (cell count, lactate, amylase, cytology, culture); liver biopsy; endoscopy for varices USS; CT abdo; Doppler flow studies for varices Other Imaging End Is there anything else I should know? Presentation Draft intro statement IBD CLD Grade severity (mild <4 stools/day; mod 4-6, severe 6-10, fulminant >10) Grade severity (Child’s classification) Differential diagnosis Findings that support / refute diagnosis Ascites Liver Cardiac Endocrine Ca Infective Renal Cirrhosis, alcoholic hepatitis, fulminant hepatic failure, Budd-Chiari syndrome CCF, veno-occlusive disease Myxoedema Peritoneal Ca TB, pancreatitis Nephrotic syndrome Abdo distension Fat, fetus, flatus, fluid, faeces, filthy great tumour, flipping enormous organs Scrotal mass Other Ca Infective Hydrocoele, epididymal cyst, spermatocoele, cyst of hydatid of Morgagni, varicocele, indirect inguinal hernia Testicular Ca Epididymitis Hepatomegaly Infective Hepatitis, hydatid disease, HIV, CMV, IMN Cancer Mets (S), CML, lymphoma, HCC (S), myeloproliferative (S) Toxins ETOH (S) Auto-immune Granulomatous, amyloid, sarcoid, SLE Other Biliary obstruction, fatty liver, CCF (S), CLD with portal HTN Firm irregular liver: cirrhosis, mets, hydatid, granuloma, amyloid, cysts, HCC Tender liver: hepatitis, RHF, Budd-Chiari, hepatocellular Ca Pulsatile liver: TR, hepatocellular Ca, vascular abnormalities Splenomegaly Infective IMN, hepatitis, IE, malaria (S), CMV Cancer Myeloproliferative (S), lymphoma S), leukaemia, CML (S) Autoimmune RA, SLE, PAN, amyloid, sarcoid Other Haemolysis, megaloblastic anaemia, portal HTN, storage diseases Hepatosplenomegaly: Infective: hepatitis, CMV, IMN, EBV Cancer: myeloproliferative, lymphoma, leukaemia Autoimmune: SLE, amyloid, sarcoid Other: CLD with portal HTN; pernicious anaemia; SCA; acromegaly; thyrotoxicosis Ballot kidneys Big kidneys: Infective Pyonephrosis Cancer RCC, lymphoma, Wilm’s tumour, neuroblastoma Autoimmune Amyloid Trauma Perirenal haematoma Other PCKD, hydronephrosis, renal vein thrombosis, acromegaly Management Suggest management and set management goals PUD H pylori: PPI + amox + Clarithromycin; repeat gastroscopy if Sx not resolved; repeat biopsy / Ur breath test to confirm cure; PPI better than H2A at healing; stop drug causing; misoprostol if NSAID IBD Correct electrolytes; avoid opiates; broad spectrum Abx if severe colitis; IV steroids if mod-severe; cyclosporin if not responding to steroids; drugs as above; topical steroids to anus; colectomy Colon Ca OT; colonscopy and ?CEA surveillance; radiation if rectal; chemo CLD Fulminant liver failure: Remove blood from gut (eg. enema); low protein diet; treat infection; correct electrolyte disturbance; avoid sedatives; Lactulose; Abx (neomycin, metronidazole); steroids if autoimmune; correct clotting Portal HTN: variceal band ligation; correct clotting; IV octreotide / terlipressin; sclerotherapy; SengstakenBlakemore; propanolol to reduce portal pressures; TIPS shunt; diuresis (spironolactone) to treat ascites; salt restriction; therapeutic paracentesis with IV albumin replacement; liver transplant Hepatitis: antivirals, interferon HAEM History HPC Haemolytic anaemia Presenting symptoms (fatigue, SOB, jaundice) Of CT disease (joint pain, swelling – sickle cell; leg ulcers – spherocytosis and sickle cell) Abdo / back pain (sickle cell); gallstones; spinal cord lesions; CVA (sickle) Fever, neuro abnormalities – TTP Thrombophilia Reason for admission; arterial / venous thrombosis; whether diagnosis of thrombotic tendancy made; dark urine at night Is there an action plan? PMH Haemolytic anaemia Protein C, protein S, AT def, APC resistance, APL ab’s, PT gene mutation, factor V Leiden; smoking, OCP, pregnancy, malignancy, recent OT / immobility; unexplained miscarriages (APL syndrome); eclampsia; prev MI (factor V); chronic leg oedema; homocystinuria Thrombophilia Generic details DH Of same; SLE; lymphoma; mechanical heart valves; external trauma; disseminated malignancy, TTP, HUS, gastro, transplant; Ca; recent glandular fever; hepatitis; mycoplasma infection Immunisation status (influenza, hep A, hep B, Pneumococcus) Haemolytic anaemia Thrombophilia Methyldopa, penicillin, quinidine, antimalarials, sulfonamides, nitrofurantoin Anticoagulation; understanding of Warfarin; INR levels; doses; target INR; frequency of blood tests; prophylaxis for OT A SH FH Occupation, adequacy of income, current housing, ability to cope, mobility + steps Hobbies (animals, chemicals, dusts), marital status, sexual problems Place of birth, overseas travel Haemolytic anaemia Thrombophilia Ethnicity (G6PD – black; thalassaemia – Greek, Italian) Transport to blood tests; how gets INR results and dose changes Haemolytic anaemia Thrombophilia Of same; sickle cell Of thrombosis; family members tested Investigation results Management Examination What did examiners examine? Did they comment on signs? Lie supine, head on 1 pillow Ask to see temperature chart General Bruising, pigmentation (lymphoma), cyanosis (polycythaemia), jaundice, scratch marks (myeloproliferative, lymphoma), leg ulcers; frontal bossing; racial origin (thalassaemia = Asian, Greek; SCA = Black) Haemolytic Pallor, jaundice, LN (lymphoma, CLL), pigmentation Thrombophilia Heparin infusion and rate; BMI Hands Koilonychia = spoon nails (Fe def); vasculitis; anaemia (palmar creases); RA; Felty’s syndrome; recurrent haemarthroses; gout (myeloprolif) Arm Epitrochlear node (non-Hodgkin’s lymphoma, CLL, IVDU, sarcoid); bruising; petechiae; palpable purpura (vasculitis); axillary LN’s Skin Thrombophilia Signs of venous insufficiency; oedema; ulceration; peri pulses Face Jaundice; pallor; scleral injection (polycythaemia); gum hypertrophy (leukaemia), ulcers, haemorrhage; atrophic Glossitis (Fe / B12 / folate def); angular stomatitis (Fe def); large tonsils (lymphoma); candida Fundi Haemolytic Retinal detachment / infarcts / vitreal haem in SCD; KF ring Sit up Neck LN’s (submental, submandibular, jugular chain, post triangle, postauricular, preauricular, occipital) Supraclavicular LN’s from front Generalised lymphadenopathy: Infection: CMV, HIV, IMN, TB, toxoplasmosis, Cancer: lymphoma, CLL, ALL, mets, Autoimmune: RA, SLE, sarcoid Other: phenytoin , Bones Sternum; clavicle; shoulders; spine tenderness Chest Haemolytic Prosthetic valve, severe AS, CCF Lie down again Abdomen Splenomegaly, hepatomegaly, signs of CLD Ask to do a rectal exam Thrombophilia Abdo wall bruising; abdo mass Groin Inguinal LN; pelvic tenderness Ask to examine testes Legs Vasculitis (HSP); bruising; pigmentation; ulceration (spherocytosis, thalassaemia, SCA); NS (SACD, peri neuropathy from B12 def) Haemolysis Joints / bone pain (SCD); leg ulceration Investigations Urine (haematuria, bile) Haemolytic anaemia Bloods Other Imaging Thrombophilia Bloods Malaria; blood film (normochromic Normocytic usually; hypochromic microcytic in thalassaemia); FBC; incr retic count; unconj bil; LDH; haptoglobin negative; Schumm’s test (methaemalbumin); schisotcytes = valve / DIC / TTP / HUS; decr plt = TTP / HUS; Coomb’s test (+ive if autoimmune); warm and cold agglutinins Urobilinogen; Hb (?mostly at night = PNH); sediment; haemosiderin FBC, ESR, Factor V Leiden, APL ab (incr lupus anticoagulant, anticardiolipin ab), AT III, protein C+S, PT gene mutation, plasma homocysteine End Is there anything else I should know? Presentation Draft intro statement Differential diagnosis Findings that support / refute diagnosis Haemolytic anaemia Warm / cold ab (lymphoma, CT disease, post-infection, drugs); microangiopathic (DIC, TTP, vasculitis), heart valve, march Hburia, infection, malaria, cirrhosis, PNH, SCD, thalassaemia (target cells, tear drops, HbFm HbA), spherocytosis, elliptocytosis, G6PD def Management Suggest management and set management goals Haemolytic anaemia Steroids / azathioprine / splenectomy if immune; transfusion; hydration; repair valve; plasmapheresis + steroids for TTP; splenectomy for ellip/sphero Thrombophilia LMWH; at least 6/12 warfarin; long term therapy of APC resistance; prophylaxis for OT or immobilisation or pregnancy; compressive stocking / foot pumps; no smoking / OCP RHEUM History HPC RA SLE Onset; presenting symptoms (fatigue, anorexia, pain, morning stiffness >1hr); joints involved; major current problem (function, pain, NS); current activity of disease; no. of jts involved; severity; functional ability; systemic involvement Skin (Raynauds, leg ulcers); eyes (Sjogren’s syndrome, scleritis, cataracts); neck pain; RS (fibrosis, pleural effusion, pleuritis); CV (pericarditis, valve disease); NS (peri neuropathy; mononeuritis multiplex; SC compression; entrapment neuropathy); anaemia, Fe def, folate def; fever; weight loss; vasculitis (ulcers) Malaise, weight loss, N+V, thrombosis, arthralgia, myalgia, rash, alopecia, ulcers, fever, neuropsychiatric, seizures, chorea, optic neuritis, CVA, headache, haematuria, oedema, renal failures, pleurisy, pericarditis, myocarditis, valve lesions, anaemia, diarrhoea, obstruction, thrombophlebitis, recurrent abortions PMH RA PUD; drug reactions; renal disease Generic details Immunisation status (influenza, hep A, hep B, Pneumococcus) DH Aspirin / NSAIDS (gastric erosions, renal impairment); Methotrexate (hepatic and pul toxicity, decr WBC + plt); penicillamine (nephrotic syndrome, decr plt, rashes, mouth ulcers, SLE, polymyositis, MG, Goodpastures); cyclosporin (BP); hydroxychloroquine, sulfasalazine (rash, haem, LFT), antiTNF ab; steroids Procainamide, hydralazine, isoniazid, methyldopa, penicillamine, chlorprom, anticonvulsants RA SLE A SH Occupation, adequacy of income, current housing, ability to cope, mobility + steps Hobbies (animals, chemicals, dusts), marital status, sexual problems Place of birth, overseas travel RA SLE FH RA Investigations Coping; mobility; ADL; fine motor skills; work; support services Understanding of implications of disease Of same Management RA Initial trt; other trt; complications of trt Examination What did examiners examine? Did they comment on signs? General Cushingoid; weight; iritis; scleritis; obvious other joint disease; gait if walked into room RA Cushings; BMI SLE Cushings, weight loss; mental state, BP, temp Discoid erythematous raised rash, photosensitivity, malar rash; scaling; hair loss Patient sitting over edge of bed; Place patient’s hand on pillow, palms down Hands Inspect Palpate Power Function Sensation RA OA Psoriatic SLE Arms BP Inspect RA SLE Scars, redness, atrophy, rash, swelling, deformity, muscle wasting, deviation, subluxation, swan necking, boutonniere, Z, sausage shaped; nails for pitting, ridging, onycholysis, hyperkeraotisis, discolouration; palmar erythema; anaemia; skin atrophy; bruising (?steroid use); signs of vasculitis Dorsal and palmar Do you have any pain anywhere? Inc ulnar styloid tenderness Synovitis, effusion; passive ROM; crepitus inc of palmar tendons (open and close hand); rheumatoid nodules on forearms Grip strength straighten fingers each individual finger (FDP - distal, FDS - prox) if Abnormal Thumb power – abduction, aduction, flexion, opposition Grip strength; key grip turning, opposition strength (a-OK), practical ability (undo button) If function mentionned, test this Symmetrical wrist, MCP and PIPJ swelling; undo a button Sweling of PIPJ and DIPJ (Bouchard’s and Heberden’s nodes) Sausage shaped fingers and telescoping of fingers; predominant IPJ disease Nail fold infarcts, vasculitis, arthropathy Wrists, elbows, shoulder – synovitis, effusions, ROM, crepitus, subluxation, palmar tendon crepitus, carpal tunnel tests (Phalen – flexion for 30secs; Tinel = tap over carpal tunnel while wrist held in extension), subcut nodules at elbows, psoriatic rash Entrapment neuropathy; subC nodules; axillary nodes Livedo reticularis, purpura, prox myopathy READ SHOULDERS Face Iritis, scleritis RA SLE Ank spond Eyes (as above); fundi; parotids; mouth (dry, ulcers, caries, TMJ) Malar rash; Alopecia, eyes (as above), mouth ulcers, rash, CN lesions, LN Uveitis Neck RA Spine, LN Chest RA SLE Ank spond Pericarditis, murmurs, effusion, fibrosis, infarct, nodules, TB Endocarditis, pleural effusion, pleurisy, ful fibrosis, collapse Decr chest expansion; AR, MVP Abdomen Palpate RA SLE Ank spond Spring pelvis Splenomegaly, epiG tenderness, inguinal LN Hepatosplenomegaly, tenderness Evidence of IBD; hepatosplenomegaly Knees Expose and lie on back Inspect Quads wasting; scars; rashes; swelling; deformity; walk; squat and look at space under knees Function Active ROM Palpate Quadriceps for wasting; tenderness; warmth; patella tap for effusion; for small, stroke up lateral Knee then medial knee to look for bulge; passive ROM; crepitus; ligaments (>5-10deg abnormal for all ligaments) Lie on front Palpate for Baker’s cysts Apley’s grinding test: flex knee to 90deg, push down on knee into bed, ex and int rotate; grinding / pain / clicking = meniscal inj Function Stand up; walk around; sit down on chair; look for varus / valgus deformity Feet Inspect Palpate RA SLE Back Inspect Palpate Movement Scars, ulcers, rashes, swelling, deformity, muscle wasting; nail changes; transverse and longitudinal arches; callus; possibly neuro examination; hallux valgus, sausage toes, claw Synovitis; effusion; passive ROM (talar, subtalar (everson-inversion), midtarsal (rotating / twisting); Achille’s tendon nodules; tenderness of plantar fasciitis; tenderness Ulcers, peri neuropathy, mono multi, cord compression Feet, prox myopathy, cerebellar ataxia, neuropathy, hemiplegia, mono multi Deformity from back and side; loss of kyphosis / lumbar lordosis Tenderness and muscle spasm Finger-floor distance; extension; lateral flexion; rotation; Schober’s test (place mark at level of post iliac spine, 10cm above and 5cm below; on bending, top and bottom marks should be >20cm apart) Investigations Ask for 1-2 recent investigations and reason for ordering Comment on results, even normal RA Bloods Other Imaging RF; anti-CCP; ESR; CRP; FBC (AOCD); U+E (if on NSAID) Urine protein, blood XR (ST swelling, jt space narrowing, juxta-articular OP, jt erosions) SLE Bloods Other Imaging ANA; anti-dsDNA; FBC (AOCD; maybe immune haemolytic; decr WBC + plt); ESR; CRP; LP if suspect neuro MRI End Is there anything else I should know? Presentation Draft intro statement Differential diagnosis Findings that support / refute diagnosis Deforming polyarthropathy RA RA, seronegative arthritis (eg. Psoriasis), gout, pseudogout, OA Psoriatic arthropathy, seronegative arthritides, chronic tophaceous gout, OA, SLE, rheumatic fever, amyloid arthropathy Management Suggest management and set management goals RA Education; physio; exercise; OT; aspirin, NSAID, COX-2 inhibitors; DMARDs (Methotrexate); gold; penicillamine; local steroid injection; OT if severe RENAL History Hello, this is exam What is wrong? Why are you in hospital this time? HPC CRF Presenting symptoms (nocturia, lethargy, loss of appetite) GN – proteinuria, haematuria, oliguria, oedema, sore throat, sepsis, rash, haemoptysis Long term prognosis Dialysis; if not, has it been discussed; transplant list?; complications – shunt blockage, thrombosis, infection, access problems, pericarditis, peritonitis Complications: anaemia, bone disease, gout, pericarditis, HTN, CCF, peri neuropathy, pruritis, PUD, cognition PMH CRF PCKD, GN, childhood UTI, DM, HTN, SLE, scleroderma Generic details DH CRF Immunisation status (influenza, hep A, hep B, Pneumococcus) NSAIDs and other analgesics, contrast, infection, ACEi ?doses altered for renal failure A SH Occupation, adequacy of income, current housing, ability to cope, mobility + steps Hobbies (animals, chemicals, dusts), marital status, sexual problems Place of birth, overseas travel CRF ADL, employment, coping, travel, sexual function, financial situation; travel to dialysis FH Investigation CRF Renal biopsy; transplant work up Management CRF Meds, diet, salt, water, EPO, protein; dialysis – where, how often, hrs/wk, complications, shunts, OT; transplant Examination What did examiners examine? Did they comment on signs? CRF General Hands Arms Face Chest Abdo Legs Back Mental state, sallow complexion, hydration, fever, Cushingoid Nails (brown lines), shunt, asterixis, neuropathy Bruising, pigmentation, scratch marks, myopathy, BP Anaemia, jaundice, band keratopathy, dry mouth, fetor, rash, saddle nose (WG), fundoscopy Pericarditis, CCF, lungs, venous hum Scars, renal mass, Tenchkoff, bladder, liver, LN, ascites, bruits, rectal Oedema, bruising, pigmentation, scratch marks, gout, neuropathy Tender, oedema Investigations Ask for 1-2 recent investigations and reason for ordering Comment on results, even normal CRF Blood Other Imaging GFR, Cr, electrolytes, phos, uric acid, Ca, alb; FBC (Burr cells, anaemia); Fe, Ferritin; PTH ?hep B/C, HIV, ANA Urine: specific gravity, pH, glucose, blood, protein, casts; renal biopsy; urine cytology USS; KUB; IVP; CT; cystoscopy; retrograde pyelography; renal angiogram End Is there anything else I should know? Presentation Draft intro statement Differential diagnosis Findings that support / refute diagnosis Management Suggest management and set management goals CRF Folate supplements; EPO; Fe supplements; antihypertensives (ACEi); trt infection; correct fluid imbalance; alter drugs if needed; trt incr Ca; trt lipids; salt and water intake; decr dietary protein; consider dialysis and transplant NS History Hello, this is exam What is wrong? Why are you in hospital this time? HPC MG Presenting symptoms (diplopia, ptosis, choking, dysarthria, chewing/swallowing probs, prox muscle weakness, fatigue OE GBS Presenting symptoms (ascending motor weakness, paraesthesia, anaesthesia, bulbar palsy, postural hypotension, arrhythmias, sphincter dysfunction) Recent resp / GI infection; recent OT, cavvincation, Ca, SLE, HIV TIA Neck pain ?aortic dissection; CV RF (see above) PMH MG GBS Prev difficult anaesthesia (prolonged weakness); prev pneumonia; thymectomy; SLE; RA Of same Generic details DH MG TIA Immunisation status (influenza, hep A, hep B, Pneumococcus) Drugs that may interfere with neuro (streptomycin, gent, quinidine, procainamide) OCP, sedatives, hypoG drugs, anticonvulsants, antiarrhythmics A SH Occupation, adequacy of income, current housing, ability to cope, mobility + steps Hobbies (animals, chemicals, dusts), marital status, sexual problems Place of birth, overseas travel FH Investigations MG Blood test / electrophysiological studies Management MG Drug and doses, time of last dose, plasma exchange, immunosuppression Examination What did examiners examine? Did they comment on signs? Sit over edge of bed CN Craniotomy scars, neurofibromata, Cushing’s syndrome, acromegaly, Paget’s disease, facial asymmetry, ptosis, proptosis, deviation of eyes, pupil inequality Inspect I Have you noticed any problems with your sense of smell? Say you would test smell, each nostril separately Lesion: URTI, meningioma, ethmoid Ca, head Ca, meningitis, hydrocephalus II VA with card to cover other eye; do you normally wear spectacles? with glasses on; read lowest line you can see clearly Visual fields with hat pin; head at arm’s length; look at my nose; bring hat pin / towards centre from each corner and middle say yes when see; map out blind spot (lateral to central field of vision) Look at fundi III, IV, XI Pupils: shape, size; direct and consensual response; RAPD (affected eye will dilate after short time when torch moved to it from normal eye = optic atrophy or v poor VA) Absent light, present accomodation: Argyll-Robertson (midbrain lesion; neurosyphilis) Adie’s (ciliary ganglion lesion; usually viral/bacterial infection) bilateral RAPD (ant visual pathway lesions) Miosis: Horner’s syndrome (ptosis, anhydrosis, miosis, apparent enopthalmos, slightly bloodshot) Argyll-Robertson (absent light, present accomodation) pontine lesion, narcotics, pilocarpine, old age Mydriasis: atropine, cocaine III palsy (ptosis, mydriasis, eye down and out) Adie’s Iritis, eye OT, traumatic, deep coma, cerebral death, congenital Accomodation: look into distance then at hatpin 15cm from end of nose Absent accomodation, present light: cortical blindness; midbrain lesion Ptosis Eye ROM: quickly look from L to R follow hatpin L (up and down) then R (up and down) Ask about diplopia; look for failure of movement and nystagmus If any abnormality, assess each eye separately V Corneal reflex with cotton wool; ask if can feel; should blink both eyes In V nerve palsy (sensation): both eyes fail to blink In VII nerve palsy (motor): contralat eye still blinks, but loss of power to ipsilateral side Facial sensation – opthalmic, maxillary, mandibular; use pin then light touch (cotton wool); also do back of head and neck (C2 and 3); close eyes, say yes when feel it In medulla / upper cervical lesion: loss of pain and temp, preservation of soft touch In pontine lesion: loss of light touch, preservation of pain and temp Muscles of mastication: clench teeth and feel masseters; open mouth and try to close In lesion: jaw deviates towards affected side Jaw jerk: incr jaw jerk in pseudobulbar palsy (=UMN) VII Facial asymmetry Look up, wrinkle forehead look for loss of wrinkles and push down on each side Loss of forehead power = LMN lesion Shut eyes try to open Grin compare nasolabial folds If LMN lesion, check ear and palate for veiscles of herpes zoster Say would check taste of anterior 2/3 tongue VIII Whisper beside ear and ask repeat; rub auricle on other ear Rinne’s: on mastoid process until no longer heard then beside ear Normal / sensorineural = note audible via air Conductive = note not audible via air Weber’s: in centre of forehead Normal = heard in middle Sensorineural = sound louder in normal ear (as abnormal is “turned off”) Conductive = sound louder in abnormal ear (as is now “turned up”) Ask for auricscope is abnormal IX, X Uvular displacement; say aaaah and look for movement Uvula goes Away from abnormal side Gag reflex – check patient can feel spatula, patient should only gag if hyperreactive Speech Cough - ?bovine (RLN lesion) Say would check taste of posterior 1/3 tongue XII Inspect tongue for wasting / fasciculation Ask to stick tongue out Tongue goes Towards abnormal side Eyes XI Shrug shoulders and feel trapezius bulk and push down; turn head against hand and feel SCM Neck Arm Carotid / cranial bruits (mastoids, temples, orbits) BP General Orbits Eyes Facies Palpate for tenderness; auscultate for bruit Lid lag, ptosis, exopthalmos (look from behind and above patient) Acuity Fields as above Eye mvmt: mvmt, diplopia, nystagmus, fatiguability (30secs looking up) Pupils: shape, size, symmetry, RAPD, accomodation Sclera for jaundice, pallor, injection Cornea for arcus, band keratopathy, KF rings Fundi: humour, disc; changes of DM, HTN, optic atrophy, papilleodema, retinal detachment, venous / artery thrombosis Corneal reflex Pancoast Eye Face Nystagmus to side of lesion; miosis; ptosis; enopthalmos Symp Decreased sweating on brow with back of finger V Ipsilateral loss of pain and temp IX, X Uvula deviated away from lesion; loss of gag reflex; hoarseness (RLN compression) NS Ipsilateral cerebellar signs Finger abduction (lower brachial plexus lesion = thoracic outlet syndrome) Signs of lung Ca: Clubbing, chest examination Signs of other Ca: LN, thyroid exam Other: carotid bruit Adie’s Eye NS Mydriasis; decr direct and consensual light response; slow accomodation Decr tendon reflexes A-R Eye NS Miosis; irregular pupil; no reaction to light; good accomodation Decr reflexes III palsy Eye Ptosis; eye down and out; mydriasis; unreactive to light (direct or consensual) and accomodation; opposite eye has consensual reflex IV palsy Eye Cannot look down and in (intort); patient walks with head tilted away from lesion VI palsy Eye Can’t look out or deviated in; diplopia on looking laterally SupraN palsy Eye Loss of upwards +/- downward gaze; pupils unequal; bilateral; reflex movements intact Bulbar palsy = LMN IX, X, XII No gag; wasted fasciculating tongue; no palatal movement; maybe no jaw jerk; NASAL SPEECH PseudoB palsy = UMN bilateral IX, X, XII Higher centre General Incr gag; spastic tongue; no palatal movement; incr jaw jerk; DONALD DUCK SPEECH; labile emotions R or L handed? Facies; obvious CN / limb lesions; level of education Shake hands Orientation Temporal Parietal Recall Language Person – his name, who I am Place – present location (country, city, building) Date – day, month, year Short term memory: rose, orchid, tulip repeat immediately Long term memory: dates of 2nd World War Dominant Acalcula = serial 7’s Agraphia = write your name Agnosia, finger L-R disorientation = put R hand on L ear, then vice versa Non-dominant Apraxia, Dressing = turn pyjama top inside out and put it on Both Sensory and visual inattention Cortical Agraphaesthesia = draw number on palm Astereognosis = name key placed in hand Apraxia, Constructional = draw clock face and numbers Rose, orchid, tulip again Nominal Name watch and pen (temporal, angular gyrus) Repetition Repeat phrase – no ifs, ands, or buts fluency, comprehension, repetition Receptive Touch your nose, then your chin (temporal, Wernicke’s) Read this then follow instruction Describe where you are (frontal, Broca’s) British constitution (cerebellum / CN) Ta ta ta, pa pa pa, ka ka ka Frontal Primitive reflexes: Grasp Pout Palmar-mental Proverb interpretation: “people in glass houses shouldn’t throw stones” Anosmia Gait Examine fundi Examine visual fields; carotid bruits; HTN; focal neurology Expressive Dysarthria MMSE Orientation Time: year, month, day, date, time Place: country, town, district, hospital, ward Registration Rose, orchid, tulip repeat Attention + calc Serial 7’s Recall Rose, orchid, tulip remember Language Name watch and pen Repeat no ifs and or buts 3 stage command: clap hands, touch nose, point to ceilling Read “close your eyes” and obey Write a sentence Copying Copy pair of intersecting pentagons Speech Say name, age and present location Say “British Constitution” Dysphasia Dysarthria Arms /5 /5 /3 /5 /3 /2 /1 /3 /1 /1 /1 Ask to name object Ask to repeat statement Ask to follow commands If abnormal: as to read and write ?expressive (Broca’s area, frontal lobe) ?receptive (Wernicke’s area, temporal lobe) ?conductive (arcuate fasciculus, temporal lobe) ?nominal (angular gyrus, temporal lobe) – can’t name Say British Constitution, West Register Street, Me Me Me, Lah Lah Lah Cerebellar = irregular staccato Examine cerebellum Lower CN = pseudoB = slow hesitant harsh strained voice Examine CN’s Lower CN = bulbar = nasal speech with imprecise articulation Take off shirt and sit over edge of bed General Facies (eg. Parkinsons, CVA); scars; skin (neurofibromata, café-au-lait); abnormal movements Shake hands Myotonia if can’t let go Inspect Wasting Fasciculation (LMN = MND, root compression, peri neuropathy, myopathy, thyrotoxicosis) Tremor Drift (UMN lesion if down, cerebellar lesion if up, post column loss in any direction) Pseudoathetosis Palpate Muscle bulk; tenderness; thickened nerves (elbow and wrist); axilla for plexus lesion Tone Wrist and elbow movement at varying velocities Neck movement Power Don’t let me……. Shrug shoulders (1) C5-6 Shoulder abduction (2) Elbow flexion (4) C6-7 Wrist flexion (6) C7-8 Shoulder adduction (3) Elbow extension (5) Wrist extension (7) Finger extension (8), flexion (9) C8-T1 Finger abduction (10) Ulnar Finger abduction and adduction – grasp paper between thumb and IF, thumb will flex if abnormal Reflexes Co-ordination Sensation Median Thumb abduction – put hand palm up on table, adduct up to touch pen, then don’t let me push thumb down 1=flicker 2=with no gravity 3=against gravity 4=weak 5=normal Augment if needed C5-6 Biceps Supinator C7-8 Triceps C8 Finger – palm upwards slightly flexed Finger nose (intention tremor, past point); dysdiadokinesis; rebound (lift arms quickly from sides then stop with palms up with eyes closed; hypotonia if unable to stop arms; and push arms) Looks for scars that may cause nerve damage; close eyes ?dermatomal / peri nerve / peri neuropathy / hemisensory Spinothalamic Pain Demonstrate on chest wall (does that feel sharp?) Sharp/dull? Start prox and test each dermatome Temp Say you would Posterior Demonstrate on clavicles Vibration: on ulnar wrist with eyes closed on elbow, on shoulder if abnormal Ask if can feel it; when feels stop Proprioception: DIPJ of index finger; demonstrate with eyes open close eyes; do wrist and shoulder if abnormal Light touch (both post and spinothalamic) with cotton wool Legs General Gait Inspect Palpate Tone Power As above + urinary catheter; look for walking stick / special shoes Walk across room, turn around, come back – with legs uncovered Hemiparetic = foot plantar flexed and swung laterally Paraparetic = scissor gait Extrapyramidal = hesitation starting, shuffling, freezing, festination, propulsion Cerebellar = drunken, widebased or reeling on narrow base; staggers to affected side Apraxic = prefrontal = glued to floor when erect, move easily when supine Post column = clumsy slapping feet on broad base High stepping = distal weakness Waddling = prox weakness Heel-toe (cerebellar) On toes and heels (S1 or L4/5 lesion) Squat and stand (prox myopathy) Romberg’s sign – feet together, arms forwards with palms up (eyes closed only = post column – Rhomberg positive if worsens with eyes closed, eyes open also = cerebellar disease) As above As above Knee and ankle, inc clonus (push patellar sharply downwards) = UMN lesion Push into me L2-3 Hip flexion (1), adduction (4) L3-4 Knee extension (6) L4-5 Hip abduction (3) Ankle dorsiflexion – toes aswell (8) L5-S1 Hip extension (2) Knee flexion (5) Reflexes Co-ordination Sensation Ankle eversion (also common peroneal nerve), inversion (9) S1 Ankle plantar flexion – toes aswell (7) Reinforce if needed L3-4 Knee S1-2 Ankle S1 Plantars (warn will be uncomfortable with key; look at big toe) Heel-shin, toe-finger, foot tapping (tap hand with ball of foot) As above; try to establish if sensory level Tuning fork on MTPJ Proprioception with big toes; knee and hip if needed Saddle region sensation (S3-5) Anal reflex (S2-4) Back Deformity, scars, tenderness, bruits; SLR Abnormal co-ordination: do gait, tone, co-ordination tests (arms and legs), Romberg’s If Romberg +ive but co-ordination OK, do vibration and position sense Nystagmus Speech (British Constitution, West Register Street) Truncal ataxia: fold arms; sit up; put legs over side of bed Fundi for papilloedla; CN’s examination LMN UMN Weakness; wasting; hypotonicity; decr reflexes; fasciculation Weakness (more marked in upper limb abductors and extensors, lower limb flexors); spasticity; clonus; incr Reflexes Upper brachial plexus (C5-6, Erb-Duchenne): loss of shoulder movement and elbow flexion; waiter’s tip; loss lateral arm and thumb sensation Lower brachial plexus (C8-T1, Klumpke): claw hand with paralysis of intrinsic muscles; loss sensation ulnar side of hand and forearm; Horner’s syndrome; look for axillary mass Cervical rib syndrome: claw hand and sensation loss as above; unequal radial pulses and BP’s; subclavian bruit; loss of pulse on manouvring arm; palpable cervical rib Radial nerve (C5-8): wrist and finger extension weakness loss of elbow extension if high Loss sensation over ASB Median nerve (C6-T1): thumb abduction weakness (APB) loss of Ochsner’s clasping test if high Loss sensation over thumb, IF, MF, lat ½ ring finger (palmar) Ulnar nerve (C8-T1): weak finger abduction and adduction and claw hand (Froment’s sign) Loss sesnation over LF and medial ½ RF (palmar and dorsal) – not forearm like lower brachial plexus Femoral nerve (L2-4): Weak knee extension, hip flexion; loss of knee jerk Loss sensation over inner aspect thigh and leg Sciatic nerve (L4-S2): Weak knee flexion, all muscle below knee foot drop; knee jerk OK; loss of ankle / plantars Loss sensaton over post thigh and total loss below knee Common peroneal (L4-S1): foot drop and loss of foot eversion; reflexes OK; inversion OK (unlike in L5 nerve root inj) Loss sensation over dorsum of foot Prox muscle weakness: myopathy, MG Myopathy Cancer Autoimmune: Polymyositis / dermatomyositis; sarcoid Toxins: ETOH; drugs (eg. Steroids) Other: periodic paralysis (hyper/hypoK); osteomalacia; endocrine (hypo/hyperthyroid, Cushings, acromegaly, hypopit); paraneoplastic; CT disease MG NS Gen GBS TIA NS Muscle fatigue, esp eyes, bulbar (read aloud), prox muscles (hold arms up); Peek sign (close eyes hard for 30secs, gets weak); neck flexion weakness Normal reflexes; normal sensation; minimal muscle atrophy Thymectomy scar CV Distal (maybe prox) muscle weakness; arms > legs; decr reflexes; muscle tenderness; minimal sensory loss; loss of vibration and proprioception No atrophy Postural BP changes, arrhythmia Eyes CV NS ?emboli, hypertensive changes, diabetic changes, ischaemic retinopathy; visual fields; nystagmus Carotid bruit; pulses; postural BP; murmurs (?IE, AS, RHD, prosthetic valve); PVD; pacemaker; GCA Dix-Hallpike if vertigo Investigations Ask for 1-2 recent investigations and reason for ordering Comment on results, even normal Urine (glucose); MRI/CT MG Bloods Other Imaging Ach receptor abs; TFT’s; RF; ANA EMG; PFT’s CXR, thoracic CT/MRI for thymoma GBS Bloods Other Monospot; cold agglutinins; CMV; HIV; Campylobacter PFT’s; incr protein on CSF with relative lack of WBCs; EMG TIA Bloods Other Imaging FBC, ESR, fasting BSL, chol, TFT; possibly ANA, anticardiolipin ab, coag Urine (?renovascular disease); ECG (?IHD / arrhythmia, long QT) CT/MRI; carotid USS; TOE End Is there anything else I should know? Presentation Draft intro statement Differential diagnosis Findings that support / refute diagnosis Horner’s SCC lung; thyroid Ca; brainstem Ca; mets; neurofibroma; base of skull lesion; Neck trauma; local OT carotid aneurysm / dissection; lat medullary syndrome; central cord syndrome; AVM; cervical rib; aortic aneurysm; cavernous sinus thrombosis cluster headache retro-orbital lesion; lower brachial plexus lesion MS; encephalitis; apical TB Postganglionic doesn’t affect sweating A-R pupil Syphilis, DM, alcoholic midbrain degeneration, other midbrain lesions Papilleodema SOL; retro-orbital mass hydrocephalus (obstructive eg. Ca; communicating eg. Choroid plexus papilloma, venous compression, subarachnoid space compression) benign intracranial HTN (idiopathic, OCP, Addisons, drugs, lat sinus thrombosis, head trauma) HTN; central retinal vein thrombosis; cerebral venous sinus thrombosis GBS Ptosis III palsy Senile; myotonic dystrophy; ocular myopathy; thyrotoxicosis; MG; botulism; snake bite; congenital; fatigue; Horner’s; tabes dorsalis; III palsy Brain stem infarct; Ca (eg. Nasopharyngeal); demyelination; trauma; aneurysm of PCOM; meningitis; DM; arteritis; cavernous sinus lesions IV palsy Trauma; lesions of cerebral peduncle VI palsy Trauma; Wernicke’s encephalopathy; raised ICP; mononeuritis multiplex; vascular; Ca; MS; DM Nystagmus Central Cerebellar lesion; INO (nystagmus in eye looking laterally, other eye fails to adduct; due to MLF lesion eg MS, brainstem infarct); brain stem lesion; phenytoin; ETOH V palsy Vascular; Ca; MS; aneurysm; meningitis; meningioma; # of middle fossa; cavernous sinus thrombosis; Sjogren’s; SLE; toxins; if all 3 regions = @ ganglion; if just 1 = post-ganglionic; if loss of pain but not touch = brain stem or upper cervical cord; if loss of touch but not pain = pontine nucleus VII palsy Vascular; Ca; MS; acoustic neuroma; meningioma; Bell’s palsy; Ramsay Hunt syubdrome; OM; fracture; sarcoid; GBS; parotid disease; mononeuritis multiplex VIII palsy Nerve Degeneration, # petrous temporla bone, aspirin, ETOH, streptomycin, rubella, congenitla syphilis; acoustic neuroma; brain stem lesion Cond Wax, OM, otosclerosis, Paget’s IX palsy Lat medullary syndrome; Ca; MND; aneurysm; meningitis; GBS XII palsy Vascular; MND; Ca; MS; vertebral artery thrombosis; meningitis; trauma; Arnold-Chiari malformation; BSF; GBS; Polio IX, X, XII Bulbar Infective Polio, neurosyphilis Vascular Brainstem CVA Other MND; syringobulbia; GBS; meningitis due to Ca/lymphoma PseudoB Vascular Internal capsule CVA Other MND; MS; high brainstem SOL; HI Multiple palsy NP Ca; chronic meningitis (eg. Carcinoma, TB, sarcoid); GBS; MFS; Arnold-Chiari malformation; brain stem lesions; trauma; basal skull lesions (eg. Mets, meningioma, Paget’s); mononeuritis multiplex (DM) MG Lambert-Eaton (power increases on repeat; may be prox muscle pain; ocular and bulbar muscles spared) Midline cerebellar SOL Midline tumour Unilat cerebellar Bilat cerebellar Peri neuropathy Other SOL Vascular Other SOL Vascular Tox Other Motor Painful Paraneoplastic syndrome Tumour, abscess, granuloma CVA; haemorrhage Paraneoplastic syndrome; MS Large Arnold-Chiari malformation Phenytoin, ETOH, Li Friedrich’s ataxia, hypothyroidism, paraneoplastic syndrome, MS, trauma Other GBS – others = PAN, porphyria Hereditary motor and sensory neuropathy; DM Tox Lead poisoning; tick/snake bite; arsenic; botulism Infective Diptheria, polio Tox ETOH, arsenic, thallium Other DM; Vit B1/B12 def; porphyria Management Suggest management and set management goals MG Anticholinesterases (pyridostigmine); may need mechanical ventilation; steroids if severe; immunosupp; thymectomy; plasmapheresis if myasthenic crisis GBS Physio, resp support, plasmapheresis, IVIG TIA CV RF control; aspirin; carotid endarterectomy; ?warfarin if AF ENDOCRINE History Hello, this is exam What is wrong? Why are you in hospital this time? HPC HyperCa DM PMH HyperCa DM Lethargy, weakness, confusion, anorexia, constipation, N+V, AP, polyuria, polydipsia; Sx of thyrotoxicosis or phaeo; recent immobilisation Age of diagnosis; presenting complaint (polyuria, polydipsia, weight loss, infection, DKA) Adequacy of control – method of testing, BSL results, regularity of testing, which metre, dose adjustment in illness Symptoms of hyperG: polyuria, thirst, weight loss, blurred vision Admissions with DKA Symptoms of hypoG and level of education: morning headaches / lethargy, night sweats, weight gain, seizures Other systems: IHD, claudication, CVD, peri neuropathy, autonomic neuropathy, erectile dysfx, syncope, eyes, nocturia, oedema, HTN, boils, necrobiosis lipiodica Action plan for hypoG Pituitary adenoma, metastatic breast Ca, lung / renal Ca, haem Ca, XS vit D, hyperthyroidism, renal failure; PUD, renal colic; pseudogout; HTN; prev parathyroid probs Cushings, phaeo; pregnancy; pancreatic disease; CLD CV RF’s (see above) Generic details Immunisation status (influenza, hep A, hep B, Pneumococcus) DH Thiazide, lithium, Ca, vit D HyperCa DM Steroids, OCP, thiazides, phenytoin; beta-blockers; ACEi for HTN A SH Occupation, adequacy of income, current housing, ability to cope, mobility + steps Hobbies (animals, chemicals, dusts), marital status, sexual problems Place of birth, overseas travel DM FH ETOH, exercise; work; living conditions; finance; eating habits; acopia with insulin; driving HyperCa DM Of same, MEN Of same; obstretic history (eg. big babies) Investigation results DM Fasting BSL >7 on 2 separate occasions; 2hr post-prandial BSL >11; HbA1c results Management Insulin / oral hypoG and when started; diet control; normal dose 0.5iu/kg/day with 40% long acting; where injected, by whom DM Examination What did examiners examine? Did they comment on signs? Standing: General Hypopit Cushings Addisons Diabetes HyperCa DM Pale skin, lack of hair; short stature; no 2Y sexual characteristics Central obesity; thin limbs; skin bruising and atrophy; skin pigmentation; poor wound healing; look at patient standing from front, sides and behind Pigmentation, vitiligo Weight, hydration, endocrine facies, pigmentation; signs of CRF Neck scar; forearm scar; LN; evidence of renal failure; signs of thyroid; pigmentation of Addisons; Evidence of sarcoid / TB; Prox weakness; corneal band keratopathy; Pseudogout Complications of disease Sit down: Hands Thyroid Tremor (place sheet over dorsal hand); onycholysis (separation from nail bed); thyroid acropachy (looks like clubbing); palmar erythema; radial pulse (tachy, AF, collapsing pulse) For hypo: cyanosis, swelling, dry skin, cold; anaemia; pulse (decr HR, small vol); test for carpal tunnel syndrome (flex both wrists for 30secs paraesthesia) Arms Thyroid Prox myopathy (more common in hyper); reflexes for briskness (delayed relaxation in hypo, fast in hyper) Trousseau sign if thyroidectomy (above SBP adducted thumb, extended PIP and DIPJ within 2mins) Lying and standing BP Purple striae; prox myopathy; BP BP, postural drop Injection sites; pulse (lying and standing for autonomic neuropathy); BP (postural hypotension); Hypopit Cushings Addisons Diabetes nails for candida; lack of slowing of pulse with valsalva; loss of sweating Face Thyroid Hypopit Cushings Diabetes Neck Thyroid Cushings Diabetes Chest Thyroid Proptosis (amount of sclera, lid retraction, lid lag by asking to follow finger as goes down at slow rate) – look from infront, behind over forehead; conjunctiva for chemosis; opthalmoplegia (loss of IO power, then convergence, then others in thyrotoxicosis); fundi for optic atrophy Chvostek’s sign if thyroidectomy (tap facial nerve 4cm infront of and below ear twitch = hypoCa For hypo: swelling, periorbital oedema, loss of outer 1/3 of eyebrows; xanthelasma; dry, fine smooth skin; carotenaemia, alopecia, vitiligo; swollen tongue; speech hoarseness; sensorineural deafness Skin wrinkles around mouth and eyes; hypophysectomy scar on forehead; bitemporal hemianopia; fundi for optic atrophy; eye ROM; trigeminal nerve Plethora; hirsutism; acne; telangectasia; moon shape; visual fields; fundi (atrophy, papilloedema, signs of HTN / DM); oral thrush Fundi – cataracts, rubeosis, retinal disease, III nerve palsy (pupil spared); ROM eyes; mouth and ears for infection; VA; Argyll-Robertson pupil; dot haemorrhage, blot haemorrhage, hard exudates, soft exudates (cotton wool spots), microaneurysms, dilated veins, new vessels, vitreous haemorrhage, scars, retinal detachment Inspect Scars, swelling, prominent veins; swallow water and look for thyroid Enlargement; voice hoarseness (RLN palsy) Pemberton’s sign (lift arms over head and look for suffusion of face, elevation of JVP, insp stridor = means there is retrosternal mass) JVP = SVC obstruction Palpate From behind with neck flexed; shape, consistency, distribution of enlargement; single / multiple nodules; tenderness; ?retrosternal extension (can you feel lower border); cervical LN’s; mobility; thrill From infront: carotid arteries (no pulse if malignant infiltration); thryoid; note tracheal position; supraclavicular LN’s; sternomastoid function Percuss Across upper chest over upper manubrium for dullness (retrosternal extension) Auscultate Bruit (active thyrotoxicosis); carotid bruit Supraclavicular fat pads; acanthosis nigricans Carotid arteries palpate and auscultate Hypopit Cushings Diabetes Gynaecomastia; ESM; CCF If hypo: pleural and pericardial effusions; sandpaper skin Decr hair, pale skin, gynaecomastia Buffalo hump (interscapular fat pad); kyphoscoliosis and tender vertebrae (osteoporosis) For signs of infection Abdo Cushings Diabetes Purple striae; adrenal mass; adrenalectomy scar; liver tumour Liver for fatty infiltration; insulin injection sites fat hypertrophy Legs Thyroid Pretibial myxoedema (firm elevated dermal nodules and plaques, pink, brown or skin coloured); vitiligo; prox myopathy; reflexes If hypo: reflexes; peri neuropathy Loss of pubic hair; testicular atrophy Squat (prox myopathy; striae; bruising; oedema Necrobiosis, hair loss, infection, pigmented scars, atrophy, ulceration, injection sites, muscle wasting, joint destruction; temperature of feet + CRT; peri pulses; oedema; peri neuropathy (including vibration and proprioception); diabetic dermopathy; femoral artery for bruits; prox muscle power Lie down: Hypopit Cushings Diabetes Investigations Ask for 1-2 recent investigations and reason for ordering Comment on results, even normal HyperCa Bloods Other Imaging Ca; PTH; Vit D 24hrs urine Ca CXR (malignancy); XR (subperiosteal reabsorption) Urine (glucose; renal stone disease, ketones, protein) End Is there anything else I should know? Presentation Draft intro statement Differential diagnosis Findings that support / refute diagnosis Diffuse goitre Idiopathic; puberty, pregnancy, post-partum Thyroiditis (Hashimoto’s, subacute, Riedel’s) Iodine def / XS; inborn errors of thryoid metabolism Drugs (eg. Li) Management Suggest management and set management goals HyperCa Parathyroidectomy; steroids; frusemide; rehydration; IV bisphosphonates; calcitonin DM Diet; exercise; insulin; metformin preferred in overweight with type II; education; regular FU; mng BP (ACEi); control CV RF; statins; regular eye review; screen urine for protein Venous stasis ulcer – most common Site: around malleoli Associated pigmentation, stasis eczema Ischaemic ulcer Large artery disease (atherosclerosis, thromboangiitis obliterans): usually lateral side of leg (pulses absent) Small vessel disease (e.g. leucocytoclastic vasculitis, palpable purpura) Malignant ulcer e.g. basal cell carcinoma (pearly translucent edge), squamous cell carcinoma (hard everted edge), melanoma, lymphoma, Kaposi’s sarcoma Infection e.g. Staphylococcus aureus, syphilitic gumma, tuberculosis, atypical Mycobacterium, fungal Neuropathic painless penetrating ulcer on sole of foot: peripheral neuropathy e.g. diabetes mellitus, tabes, leprosy) Underlying systemic disease Diabetes mellitus: vascular disease, neuropathy or necrobiosis lipoidica (front of leg) Pyoderma gangrenosum Rheumatoid arthritis Lymphoma Haemolytic anaemia (small ulcers over malleoli), e.g. sickle cell anaemia Equipment: Piece of paper Sleeve of shirt with button Card to cover opposite eye on VA check Red tipped hat pin