Profile of Prof. Hirokawa
Name: Nobutaka Hirokawa
Contact address:
Department of Cell Biology and Anatomy and Department of Molecular Structure and Dynamics,
Graduate School of Medicine, The University of Tokyo，Japan
e-mail: hirokawa@m.u-tokyo.ac.jp
tel: +81-3-5841-3336
fax: +81-3-5802-8646
EDUCATION :
1971 - M.D., University of Tokyo, Medical School
1978 - Ph.D., Department of Anatomy and Cell Biology, University of Tokyo, Faculty of Medicine
(Neurobiology, Cell Biology)
1980 - Postdoctoral, University of California San Francisco (Cell Biology, Neurobiology)
1981 - Postdoctoral, Washington University, School of Medicine (Cell Biology, Neurobiolgy)
TEACHING, RESEARCH and other APPOINTMENTS :
1972 - 1981 Assistant Professor of Anatomy (Tenured), University of Tokyo, Medical School .
1979 - 1980 Reseach Fellow (The Fogarty International Exchanging Fellow of NIH in Department of
Physiology, University of California, San Francisco.
1980 - 1981 Research Fellow in Department of Physiology and Biophysics, Washington University,
School of Medicine.
1981 - 1983 Research Assistant Professor of Physiology and Biophysics, Washington University,
School of Medicine, St. Louis, Missouri.
1983 - 1983 Associate Professor of Anatomy and Neurobiology, Washington University, School of
Medicine, St. Louis, Missouri.
1983 - 2009 Professor and Chairman of Anatomy and Cell Biology, University of Tokyo, Faculty of
Medicine.
2003 - 2007 Dean, Graduate School of Medicine, University of Tokyo.
2010 - present Project Professor, Department of Cell Biology and Anatomy and Department of
Molecular Structure and Dynamics Graduate School of Medicine, The University of Tokyo.
2012 - present President, International Federation for Cell Biology (IFCB).
2012 - present President, Progress in Neurobiology Human Frontier Science Program (HFSP)
EDITOR/ASSOCIATE EDITOR/EDITORIAL BOARD :
Current

Cell (1998-)

Neuron (1990-)

Journal of Cell Biology (1997-)

EMBO Journal (2005-)

Current Opinion in Cell Biology (1995-)

Trends in Cell Biology (1999-)

Developmental Cell (2001-)

Experimental Cell Research (1999-)

Progress in Neurobiology (1999-)

Cell Structure and Function (1987-)

Neuroscience Research (1990-)
Past

Current Opinion in Neurobiology (1991-1996)

Anatomical Record (1994-1998)

Science (1995-1999)

European Journal of Cell Biology (1995-2003)

European Journal of Biochemistry (1999-2004)

Journal of Neurocytology (1992-2008)

Journal of Cell Science (1990-2009)
HONORS :

1985 Seto Prize from the Japanese Society of Electron Microscopy

1987 Tsukahara Prize from the Brain Science Foundation

1991 The highest Prize from the Japanese Society for Basic Medical Science

1995 Uehara Prize from the Uehara Life Science Foundation

1996 Asahi Prize from the Asahi Newspaper Company

1998 Takeda Medical Prize from the Takeda Science Foundation

1999 The Japan Academy Prize from the Japan Academy

1999 Fujiwara Prize from Fujiwara Foundation

2003 Elected Associate Member of EMBO (Europian Molecular Biology Organization)

2004 Member of The Japan Academy (Section II, Department 7 (Medicine, Pharmacy and
Dentistry)) (December 13. 2004)

2005 Eduard Buchner-Prize from German Society for Biochemistry and Molecular Biology
PUBLICATIONS :
1. N. Hirokawa.Disappearance of afferent and efferent nerve terminals in the inner ear of the
chick embryo after chronic treatment with beta-bungarotoxin. The Journal of Cell Biology
73(1): 27-46. 1977.
2. N. Hirokawa and M. Kitamura.Binding of Clostridium botulinum neurotoxin to the presynaptic
membrane in the central nervous system. The Journal of Cell Biology 81(1): 43-9. 1979.
3. N. Hirokawa and J. E. Heuser.Structural evidence that botulinum toxin blocks neuromuscular
transmission by impairing the calcium influx that normally accompanies nerve depolarization.
The Journal of Cell Biology 88(1): 160-71. 1981.
4. N. Hirokawa and J. E. Heuser.Quick-freeze, deep-etch visualization of the cytoskeleton beneath
surface differentiations of intestinal epithelial cells. The Journal of Cell Biology 91(2 Pt 1):
399-409. 1981.
5. N. Hirokawa and J. E. Heuser.Internal and external differentiations of the postsynaptic
membrane at the neuromuscular junction. Journal of Neurocytology 11(3): 487-510. 1982.
6. N. Hirokawa.Cross-linker system between neurofilaments, microtubules, and membranous
organelles in frog axons revealed by the quick-freeze, deep-etching method. The Journal of Cell
Biology 94(1): 129-42. 1982.
7. N. Hirokawa, L. G. Tilney, K. Fujiwara, and J. E. Heuser.Organization of actin, myosin, and
intermediate filaments in the brush border of intestinal epithelial cells. The Journal of Cell
Biology 94(2): 425-43. 1982.
8. N. Hirokawa and L. G. Tilney.Interactions between actin filaments and between actin filaments
and membranes in quick-frozen and deeply etched hair cells of the chick ear. The Journal of
Cell Biology 95(1): 249-61. 1982.
9. N. Hirokawa and J. Heuser.The inside and outside of gap-junction membranes visualized by
deep etching. Cell 30(2): 395-406. 1982.
10. N. Hirokawa, R. E. Cheney, and M. Willard.Location of a protein of the fodrin-spectrinTW260/240 family in the mouse intestinal brush border. Cell 32(3): 953-65. 1983.
11. N. Hirokawa.Membrane specialization and cytoskeletal structure in the synapse and axon
revealed by the quick-freeze, deep-etching method. In "Structure and Function in Excitable
Cells" D. C. Chang, I. Tasaki, W. Adelman, and R. Leuchtag editors. Plenum Press. 113-141.
1983.
12. N. Hirokawa, T. C. Keller, 3rd, R. Chasan, and M. S. Mooseker.Mechanism of brush border
contractility studied by the quick-freeze, deep-etch method. The Journal of Cell Biology 96(5):
1325-36. 1983.
13. N. Hirokawa, M. A. Glicksman, and M. B. Willard.Organization of mammalian neurofilament
polypeptides within the neuronal cytoskeleton. The Journal of Cell Biology 98(4): 1523-36.
1984.
14. N. Hirokawa, G. S. Bloom, and R. B. Vallee.Cytoskeletal architecture and
immunocytochemical localization of microtubule-associated proteins in regions of axons
associated with rapid axonal transport: the beta,beta'- iminodipropionitrile-intoxicated axon as a
model system. The Journal of Cell Biology 101(1): 227-39. 1985.
15. N. Hirokawa, R. Takemura, and S. Hisanaga.Cytoskeletal architecture of isolated mitotic
spindle with special reference to microtubule-associated proteins and cytoplasmic dynein. The
Journal of Cell Biology 101(5 Pt 1): 1858-70. 1985.
16. N. Hirokawa.Quick-freeze, deep-etch visualization of the axonal cytoskeleton. Trends in
Neurosciences 9: 67-70. 1986.
17. N. Hirokawa.270K microtubule-associated protein cross-reacting with anti-MAP2 IgG in the
crayfish peripheral nerve axon. The Journal of Cell Biology 103(1): 33-9. 1986.
18. N. Hirokawa.Quick freeze, deep etch of the cytoskeleton. Methods in Enzymology 134:
598-612. 1986.
19. H. Murofushi, S. Kotani, H. Aizawa, S. Hisanaga, N. Hirokawa, and H. Sakai.Purification and
characterization of a 190-kD microtubule-associated protein from bovine adrenal cortex. The
Journal of Cell Biology 103(5): 1911-9. 1986.
20. Y. Shiomura and N. Hirokawa.The molecular structure of microtubule-associated protein 1A
(MAP1A) in vivo and in vitro. An immunoelectron microscopy and quick-freeze, deep-etch
study. The Journal of Neuroscience : 7(5): 1461-9. 1987.
21. N. Hirokawa and S. Hisanaga."Buttonin," a unique button-shaped microtubule-associated
protein (75 kD) that decorates spindle microtubule surface hexagonally. The Journal of Cell
Biology 104(6): 1553-61. 1987.
22. Y. Shiomura and N. Hirokawa.Colocalization of microtubule-associated protein 1A and
microtubule-associated protein 2 on neuronal microtubules in situ revealed with double-label
immunoelectron microscopy. The Journal of Cell Biology 104(6): 1575-8. 1987.
23. S. Hisanaga and N. Hirokawa.Substructure of sea urchin egg cytoplasmic dynein. Journal of
Molecular Biology 195(4): 919-27. 1987.
24. T. Nakata and N. Hirokawa.Cytoskeletal reorganization of human platelets after stimulation
revealed by the quick-freeze deep-etch technique. The Journal of Cell Biology 105(4): 1771-80.
1987.
25. N. Hirokawa, S. Hisanaga, and Y. Shiomura.MAP2 is a component of crossbridges between
microtubules and neurofilaments in the neuronal cytoskeleton: quick-freeze, deep-etch
immunoelectron microscopy and reconstitution studies. The Journal of Neuroscience : 8(8):
2769-79. 1988.
26. N. Hirokawa, Y. Shiomura, and S. Okabe.Tau proteins: the molecular structure and mode of
binding on microtubules. The Journal of Cell Biology 107(4): 1449-59. 1988.
27. S. Hisanaga and N. Hirokawa.Structure of the peripheral domains of neurofilaments revealed
by low angle rotary shadowing. Journal of Molecular Biology 202(2): 297-305. 1988.
28. S. Okabe and N. Hirokawa.Microtubule dynamics in nerve cells: analysis using microinjection
of biotinylated tubulin into PC12 cells. The Journal of Cell Biology 107(2): 651-64. 1988.
29. N. Hirokawa.The arrangement of actin filaments in the postsynaptic cytoplasm of the cerebellar
cortex revealed by quick-freeze deep-etch electron microscopy. Neuroscience Research 6(3):
269-75. 1989.
30. N. Hirokawa, K. Sobue, K. Kanda, A. Harada, and H. Yorifuji.The cytoskeletal architecture of
the presynaptic terminal and molecular structure of synapsin 1. The Journal of Cell Biology
108(1): 111-26. 1989.
31. S. Okabe and N. Hirokawa.Axonal transport. Current Opinion in Cell Biology 1(1): 91-7. 1989.
32. S. Okabe, Y. Shiomura, and N. Hirokawa.Immunocytochemical localization of
microtubule-associated proteins 1A and 2 in the rat retina. Brain Research 483(2): 335-46.
1989.
33. N. Hirokawa, K. K. Pfister, H. Yorifuji, M. C. Wagner, S. T. Brady, and G. S. Bloom.
Submolecular domains of bovine brain kinesin identified by electron microscopy and
monoclonal antibody decoration. Cell 56(5): 867-78. 1989.
34. S. Hisanaga and N. Hirokawa.The effects of dephosphorylation on the structure of the
projections of neurofilament. The Journal of Neuroscience : 9(3): 959-66. 1989.
35. S. Okabe and N. Hirokawa.Rapid turnover of microtubule-associated protein MAP2 in the axon
revealed by microinjection of biotinylated MAP2 into cultured neurons. Proceedings of the
National Academy of Sciences of the United States of America 86(11): 4127-31. 1989.
36. Y. Kanai, R. Takemura, T. Oshima, H. Mori, Y. Ihara, M. Yanagisawa, T. Masaki, and N.
Hirokawa.Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts
transfected with a single tau cDNA. The Journal of Cell Biology 109(3): 1173-84. 1989.
37. R. Sato-Yoshitake, Y. Shiomura, H. Miyasaka, and N. Hirokawa.Microtubule-associated
protein 1B: molecular structure, localization, and phosphorylation-dependent expression in
developing neurons. Neuron 3(2): 229-38. 1989.
38. S. Okabe and N. Hirokawa.Incorporation and turnover of biotin-labeled actin microinjected
into fibroblastic cells: an immunoelectron microscopic study. The Journal of Cell Biology
109(4 Pt 1): 1581-95. 1989.
39. Y. Shiomura and N. Hirokawa.A novel heat-stable 205 kDa microtubule-associated protein is
involved in the neural development of the rat brain. Brain Research 502(2): 356-64. 1989.
40. T. Nakata, K. Sobue, and N. Hirokawa.Conformational change and localization of calpactin I
complex involved in exocytosis as revealed by quick-freeze, deep-etch electron microscopy and
immunocytochemistry. The Journal of Cell Biology 110(1): 13-25. 1990.
41. S. Okabe and N. Hirokawa.Turnover of fluorescently labelled tubulin and actin in the axon.
Nature 343(6257): 479-82. 1990.
42. S. Hisanaga, A. Ikai, and N. Hirokawa.Molecular architecture of the neurofilament. I. Subunit
arrangement of neurofilament L protein in the intermediate-sized filament. Journal of
Molecular Biology 211(4): 857-69. 1990.
43. S. Hisanaga and N. Hirokawa.Molecular architecture of the neurofilament. II. Reassembly
process of neurofilament L protein in vitro. Journal of Molecular Biology 211(4): 871-82.
1990.
44. S. Hisanaga, Y. Gonda, M. Inagaki, A. Ikai, and N. Hirokawa.Effects of phosphorylation of the
neurofilament L protein on filamentous structures. Cell Regulation 1(2): 237-48. 1990.
45. N. Hirokawa, R. Sato-Yoshitake, T. Yoshida, and T. Kawashima.Brain dynein (MAP1C)
localizes on both anterogradely and retrogradely transported membranous organelles in vivo.
The Journal of Cell Biology 111(3): 1027-37. 1990.
46. S. Okabe and N. Hirokawa.Actin dynamics in growth cones. 11(7): 1918-29. 1991.
47. N. Hirokawa, R. Sato-Yoshitake, N. Kobayashi, K. K. Pfister, G. S. Bloom, and S. T. Brady.
Kinesin associates with anterogradely transported membranous organelles in vivo. The Journal
of Cell Biology 114(2): 295-302. 1991.
48. T. Nakata, A. Iwamoto, Y. Noda, R. Takemura, H. Yoshikura, and N. Hirokawa.Predominant
and developmentally regulated expression of dynamin in neurons. Neuron 7(3): 461-9. 1991.
49. R. Takemura, Y. Kanai, and N. Hirokawa.In situ localization of tau mRNA in developing rat
brain. Neuroscience 44(2): 393-407. 1991.
50. M. Takeuchi, S. Hisanaga, T. Umeyama, and N. Hirokawa.The 72-kDa microtubule-associated
protein from porcine brain. Journal of Neurochemistry 58(4): 1510-6. 1992.
51. S. Okabe and N. Hirokawa.Differential behavior of photoactivated microtubules in growing
axons of mouse and frog neurons. The Journal of Cell Biology 117(1): 105-20. 1992.
52. N. Hirokawa and S. Okabe.Microtubules on the move? Current Biology : CB 2(4): 193-5. 1992.
53. T. Nakata and N. Hirokawa.Organization of cortical cytoskeleton of cultured chromaffin cells
and involvement in secretion as revealed by quick-freeze, deep-etching, and double-label
immunoelectron microscopy. The Journal of Neuroscience : 12(6): 2186-97. 1992.
54. T. Oshima, S. Okabe, and N. Hirokawa.Immunocytochemical localization of 205 kDa
microtubule-associated protein (205 kDa MAP) in the guinea pig organ of Corti. Brain
Research 590(1-2): 53-65. 1992.
55. K. Maeda, T. Nakata, Y. Noda, R. Sato-Yoshitake, and N. Hirokawa.Interaction of dynamin
with microtubules: its structure and GTPase activity investigated by using highly purified
dynamin. Molecular Biology of the Cell 3(10): 1181-94. 1992.
56. Y. Kanai, J. Chen, and N. Hirokawa.Microtubule bundling by tau proteins in vivo: analysis of
functional domains. The EMBO Journal 11(11): 3953-61. 1992.
57. H. Aizawa, Y. Sekine, R. Takemura, Z. Zhang, M. Nangaku, and N. Hirokawa.Kinesin family
in murine central nervous system. The Journal of Cell Biology 119(5): 1287-96. 1992.
58. Y. Tanaka, K. Kawahata, T. Nakata, and N. Hirokawa.Chronological expression of
microtubule-associated proteins (MAPs) in EC cell P19 after neuronal induction by retinoic
acid. Brain Research 596(1-2): 269-78. 1992.
59. J. Chen, Y. Kanai, N. J. Cowan, and N. Hirokawa.Projection domains of MAP2 and tau
determine spacings between microtubules in dendrites and axons. Nature 360(6405): 674-7.
1992.
60. R. Takemura, S. Okabe, T. Umeyama, Y. Kanai, N. J. Cowan, and N. Hirokawa.Increased
microtubule stability and alpha tubulin acetylation in cells transfected with microtubuleassociated proteins MAP1B, MAP2 or tau. Journal of Cell Science 103 ( Pt 4): 953-64. 1992.
61. R. Takemura, S. Okabe, N. Kobayashi, and N. Hirokawa.Reorganization of brain spectrin
(fodrin) during differentiation of PC12 cells. Neuroscience 52(2): 381-91. 1993.
62. T. Umeyama, S. Okabe, Y. Kanai, and N. Hirokawa.Dynamics of microtubules bundled by
microtubule associated protein 2C (MAP2C). The Journal of Cell Biology 120(2): 451-65.
1993.
63. S. Okabe and N. Hirokawa.Do photobleached fluorescent microtubules move?: re-evaluation of
fluorescence laser photobleaching both in vitro and in growing Xenopus axon. The Journal of
Cell Biology 120(5): 1177-86. 1993.
64. S. Okabe, H. Miyasaka, and N. Hirokawa.Dynamics of the neuronal intermediate filaments.
The Journal of Cell Biology 121(2): 375-86. 1993.
65. T. Nakata, R. Takemura, and N. Hirokawa.A novel member of the dynamin family of
GTP-binding proteins is expressed specifically in the testis. Journal of Cell Science 105 ( Pt 1):
1-5. 1993.
66. Y. Noda, T. Nakata, and N. Hirokawa.Localization of dynamin: widespread distribution in
mature neurons and association with membranous organelles. Neuroscience 55(1): 113-27.
1993.
67. Z. Zhang, Y. Tanaka, S. Nonaka, H. Aizawa, H. Kawasaki, T. Nakata, and N. Hirokawa.
The primary structure of rat brain (cytoplasmic) dynein heavy chain, a cytoplasmic motor
enzyme. Proceedings of the National Academy of Sciences of the United States of America
90(17): 7928-32. 1993.
68. N. Hirokawa.Axonal transport and the cytoskeleton. Current Opinion in Neurobiology 3(5):
724-31. 1993.
69. N. Hirokawa.Mechanism of axonal transport. Identification of new molecular motors and
regulations of transports. Neuroscience Research 18(1): 1-9. 1993.
70. N. Hirokawa.The neuronal cytoskeleton: Its role in neuronal morphogenesis and organelle
transport. In "Neuronal Cytoskeleton: Morphogenesis, Transport, and Synaptic Transmission"
N. Hirokawa editor. CRC Press. 3-32. 1993.
71. N. Hirokawa.Microtubule organization and dynamics dependent on microtubule-associated
proteins. Current Opinion in Cell Biology 6(1): 74-81. 1994.
72. S. Hisanaga, Y. Matsuoka, K. Nishizawa, T. Saito, M. Inagaki, and N. Hirokawa.
Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and
NF-H by the catalytic subunit of cAMP-dependent protein kinase. Molecular Biology of the
Cell 5(2): 161-72. 1994.
73. A. Harada, K. Oguchi, S. Okabe, J. Kuno, S. Terada, T. Ohshima, R. Sato-Yoshitake, Y. Takei,
T. Noda, and N. Hirokawa.Altered microtubule organization in small-calibre axons of mice
lacking tau protein. Nature 369(6480): 488-91. 1994.
74. S. Kondo, R. Sato-Yoshitake, Y. Noda, H. Aizawa, T. Nakata, Y. Matsuura, and N. Hirokawa.
KIF3A is a new microtubule-based anterograde motor in the nerve axon. The Journal of Cell
Biology 125(5): 1095-107. 1994.
75. Y. Sekine, Y. Okada, Y. Noda, S. Kondo, H. Aizawa, R. Takemura, and N. Hirokawa.A novel
microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated
developmentally. The Journal of Cell Biology 127(1): 187-201. 1994.
76. A. Ando, K. Yonezawa, I. Gout, T. Nakata, H. Ueda, K. Hara, Y. Kitamura, Y. Noda, T.
Takenawa, and N. Hirokawa.A complex of GRB2-dynamin binds to tyrosine-phosphorylated
insulin receptor substrate-1 after insulin treatment. The EMBO Journal 13(13): 3033-8. 1994.
77. S. Takeda, S. Okabe, T. Funakoshi, and N. Hirokawa.Differential dynamics of neurofilament-H
protein and neurofilament-L protein in neurons. The Journal of Cell Biology 127(1): 173-85.
1994.
78. M. Kikkawa, T. Ishikawa, T. Nakata, T. Wakabayashi, and N. Hirokawa.Direct visualization of
the microtubule lattice seam both in vitro and in vivo. The Journal of Cell Biology 127(6 Pt 2):
1965-71. 1994.
79. M. Nangaku, R. Sato-Yoshitake, Y. Okada, Y. Noda, R. Takemura, H. Yamazaki, and N.
Hirokawa.KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport
of mitochondria. Cell 79(7): 1209-20. 1994.
80. Y. Kanai and N. Hirokawa.Sorting mechanisms of tau and MAP2 in neurons: suppressed
axonal transit of MAP2 and locally regulated microtubule binding. Neuron 14(2): 421-32.
1995.
81. T. Nakagawa, J. Chen, Z. Zhang, Y. Kanai, and N. Hirokawa.Two distinct functions of the
carboxyl-terminal tail domain of NF-M upon neurofilament assembly: cross-bridge formation
and longitudinal elongation of filaments. The Journal of Cell Biology 129(2): 411-29. 1995.
82. Y. Noda, R. Sato-Yoshitake, S. Kondo, M. Nangaku, and N. Hirokawa.KIF2 is a new
microtubule-based anterograde motor that transports membranous organelles distinct from
those carried by kinesin heavy chain or KIF3A/B. The Journal of Cell Biology 129(1): 157-67.
1995.
83. Y. Okada, R. Sato-Yoshitake, and N. Hirokawa.The activation of protein kinase A pathway
selectively inhibits anterograde axonal transport of vesicles but not mitochondria transport or
retrograde transport in vivo. The Journal of Neuroscience : 15(4): 3053-64. 1995.
84. Y. Okada, H. Yamazaki, Y. Sekine-Aizawa, and N. Hirokawa.The neuron-specific kinesin
superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of
synaptic vesicle precursors. Cell 81(5): 769-80. 1995.
85. Y. Tanaka, Z. Zhang, and N. Hirokawa.
Identification and molecular evolution of new dynein-like protein sequences in rat brain.
Journal of Cell Science 108 ( Pt 5): 1883-93. 1995.
86. S. Takeda, T. Funakoshi, and N. Hirokawa.Tubulin dynamics in neuronal axons of living
zebrafish embryos. Neuron 14(6): 1257-64. 1995.
87. M. Kikkawa, T. Ishikawa, T. Wakabayashi, and N. Hirokawa.Three-dimensional structure of
the kinesin head-microtubule complex. Nature 376(6537): 274-7. 1995.
88. R. Takemura, S. Okabe, T. Umeyama, and N. Hirokawa.Polarity orientation and assembly
process of microtubule bundles in nocodazole-treated, MAP2c-transfected COS cells.
Molecular Biology of the Cell 6(8): 981-96. 1995.
89. H. Yamazaki, T. Nakata, Y. Okada, and N. Hirokawa.KIF3A/B: a heterodimeric kinesin
superfamily protein that works as a microtubule plus end-directed motor for membrane
organelle transport. The Journal of Cell Biology 130(6): 1387-99. 1995.
90. T. Nakata and N. Hirokawa.Point mutation of adenosine triphosphate-binding motif generated
rigor kinesin that selectively blocks anterograde lysosome membrane transport. The Journal of
Cell Biology 131(4): 1039-53. 1995.
91. Y. Takei, A. Harada, S. Takeda, K. Kobayashi, S. Terada, T. Noda, T. Takahashi, and N.
Hirokawa.Synapsin I deficiency results in the structural change in the presynaptic terminals in
the murine nervous system. The Journal of Cell Biology 131(6 Pt 2): 1789-800. 1995.
92. R. Takemura, T. Nakata, Y. Okada, H. Yamazaki, Z. Zhang, and N. Hirokawa. mRNA
expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein
during axonal regeneration. The Journal of Neuroscience : 16(1): 31-5. 1996.
93. N. Hirokawa, T. Funakoshi, R. Sato-Harada, and Y. Kanai.Selective stabilization of tau in
axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to
polarized localization of cytoskeletal proteins in mature neurons. The Journal of Cell Biology
132(4): 667-79. 1996.
94. N. Hirokawa.Organelle transport along microtubules - the role of KIFs. Trends in Cell Biology
6(4): 135-41. 1996.
95. P. L. Beech, K. Pagh-Roehl, Y. Noda, N. Hirokawa, B. Burnside, and J. L. Rosenbaum.
Localization of kinesin superfamily proteins to the connecting cilium of fish photoreceptors.
Journal of Cell Science 109 ( Pt 4): 889-97. 1996.
96. T. Funakoshi, S. Takeda, and N. Hirokawa.Active transport of photoactivated tubulin
molecules in growing axons revealed by a new electron microscopic analysis. The Journal of
Cell Biology 133(6): 1347-53. 1996.
97. S. Terada, T. Nakata, A. C. Peterson, and N. Hirokawa.Visualization of slow axonal transport
in vivo. Science 273(5276): 784-8. 1996.
98. H. Yamazaki, T. Nakata, Y. Okada, and N. Hirokawa.Cloning and characterization of KAP3: a
novel kinesin superfamily-associated protein of KIF3A/3B. Proceedings of the National
Academy of Sciences of the United States of America 93(16): 8443-8. 1996.
99. S. G. Wolf, E. Nogales, M. Kikkawa, D. Gratzinger, N. Hirokawa, and K. H. Downing.
Interpreting a medium-resolution model of tubulin: comparison of zinc-sheet and microtubule
structure. Journal of Molecular Biology 262(4): 485-501. 1996.
100. N. Saito, Y. Okada, Y. Noda, Y. Kinoshita, S. Kondo, and N. Hirokawa.KIFC2 is a novel
neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of
multivesicular body-like organelles. Neuron 18(3): 425-38. 1997.
101. Y. Takei, S. Kondo, A. Harada, S. Inomata, T. Noda, and N. Hirokawa.Delayed development
of nervous system in mice homozygous for disrupted microtubule-associated protein 1B
(MAP1B) gene. The Journal of Cell Biology 137(7): 1615-26. 1997.
102. T. Nakagawa, Y. Tanaka, E. Matsuoka, S. Kondo, Y. Okada, Y. Noda, Y. Kanai, and N.
Hirokawa.Identification and classification of 16 new kinesin superfamily (KIF) proteins in
mouse genome. Proceedings of the National Academy of Sciences of the United States of
America 94(18): 9654-9. 1997.
103. N. Hirokawa, S. Terada, T. Funakoshi, and S. Takeda.Slow axonal transport: the subunit
transport model. Trends in Cell Biology 7: 384-388. 1997.
104. N. Hirokawa.The mechanisms of fast and slow transport in neurons: identification and
characterization of the new kinesin superfamily motors. Current Opinion in Neurobiology 7(5):
605-14. 1997.
105. K. i. Nagata, A. Puls, C. Futter, P. Aspenstrom, E. Schaefer, T. Nakata, N. Hirokawa, and A.
Hall.The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules
and associates with kinesin superfamily motor KIF3. The EMBO Journal 17(1): 149-58. 1998.
106. N. Hirokawa.Kinesin and dynein superfamily proteins and the mechanism of organelle
transport. Science 279(5350): 519-26. 1998.
107. T. Nakata, S. Terada, and N. Hirokawa.Visualization of the dynamics of synaptic vesicle and
plasma membrane proteins in living axons. The Journal of Cell Biology 140(3): 659-74. 1998.
108. N. Hirokawa, Y. Noda, and Y. Okada.Kinesin and dynein superfamily proteins in organelle
transport and cell division. Current Opinion in Cell Biology 10(1): 60-73. 1998.
109. A. Harada, Y. Takei, Y. Kanai, Y. Tanaka, S. Nonaka, and N. Hirokawa.Golgi vesiculation
and lysosome dispersion in cells lacking cytoplasmic dynein. The Journal of Cell Biology
141(1): 51-9. 1998.
110. Y. Yonekawa, A. Harada, Y. Okada, T. Funakoshi, Y. Kanai, Y. Takei, S. Terada, T. Noda,
and N. Hirokawa.Defect in synaptic vesicle precursor transport and neuronal cell death in
KIF1A motor protein-deficient mice. The Journal of Cell Biology 141(2): 431-41. 1998.
111. Y. Tanaka, Y. Kanai, Y. Okada, S. Nonaka, S. Takeda, A. Harada, and N. Hirokawa.
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal
perinuclear clustering of mitochondria. Cell 93(7): 1147-58. 1998.
112. W. Kim, Y. Tang, Y. Okada, T. A. Torrey, S. K. Chattopadhyay, M. Pfleiderer, F. G. Falkner,
F. Dorner, W. Choi, N. Hirokawa, and H. C. Morse, 3rd.Binding of murine leukemia virus Gag
polyproteins to KIF4, a microtubule-based motor protein. Journal of Virology 72(8): 6898-901.
1998.
113. N. Hirokawa and S. Takeda.Gene targeting studies begin to reveal the function of
neurofilament proteins. The Journal of Cell Biology 143(1): 1-4. 1998.
114. N. Santama, J. Krijnse-Locker, G. Griffiths, Y. Noda, N. Hirokawa, and C. G. Dotti.KIF2beta,
a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may
be implicated in their centrifugal translocation. The EMBO Journal 17(20): 5855-67. 1998.
115. N. Hirokawa.Kinesin superfamily proteins (KIFs) and the mechanism of organelle transport.
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the 21st Century" S. Yagihashi, T. Kachi, and M. Wakui editors. Elsevier Science. 17-30. 1998.
116. S. Nonaka, Y. Tanaka, Y. Okada, S. Takeda, A. Harada, Y. Kanai, M. Kido, and N. Hirokawa.
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of
extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95(6): 829-37. 1998.
117. Y. Okada and N. Hirokawa.
A processive single-headed motor: kinesin superfamily protein KIF1A. Science 283(5405):
1152-7. 1999.
118. S. Takeda, Y. Yonekawa, Y. Tanaka, Y. Okada, S. Nonaka, and N. Hirokawa.Left-right
asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality
and mesoderm induction by kif3A-/- mice analysis. The Journal of Cell Biology 145(4): 825-36.
1999.
119. S. Terada, T. Tsujimoto, Y. Takei, T. Takahashi, and N. Hirokawa.Impairment of inhibitory
synaptic transmission in mice lacking synapsin I. The Journal of Cell Biology 145(5): 1039-48.
1999.
120. Y. Okada, S. Nonaka, Y. Tanaka, Y. Saijoh, H. Hamada, and N. Hirokawa.Abnormal nodal
flow precedes situs inversus in iv and inv mice. Molecular Cell 4(4): 459-68. 1999.
121. Y. Okada and N. Hirokawa.Mechanism of the single-headed processivity: diffusional
anchoring between the K-loop of kinesin and the C terminus of tubulin. Proceedings of the
National Academy of Sciences of the United States of America 97(2): 640-5. 2000.
122. M. Kikkawa, Y. Okada, and N. Hirokawa.15 A resolution model of the monomeric kinesin
motor, KIF1A. Cell 100(2): 241-52. 2000.
123. S. Takeda, H. Yamazaki, D. H. Seog, Y. Kanai, S. Terada, and N. Hirokawa. Kinesin
superfamily protein 3 (KIF3) motor transports fodrin-associating vesicles important for neurite
building. The Journal of Cell Biology 148(6): 1255-65. 2000.
124. M. Setou, T. Nakagawa, D. H. Seog, and N. Hirokawa.Kinesin superfamily motor protein
KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288(5472):
1796-802. 2000.
125. Y. Kanai, Y. Okada, Y. Tanaka, A. Harada, S. Terada, and N. Hirokawa.KIF5C, a novel
neuronal kinesin enriched in motor neurons. The Journal of Neuroscience : 20(17): 6374-84.
2000.
126. Y. Takei, J. Teng, A. Harada, and N. Hirokawa.Defects in axonal elongation and neuronal
migration in mice with disrupted tau and map1b genes. The Journal of Cell Biology 150(5):
989-1000. 2000.
127. S. Terada, M. Kinjo, and N. Hirokawa.Oligomeric tubulin in large transporting complex is
transported via kinesin in squid giant axons. Cell 103(1): 141-55. 2000.
128. J. Chen, T. Nakata, Z. Zhang, and N. Hirokawa.The C-terminal tail domain of neurofilament
protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation.
Journal of Cell Science 113 Pt 21: 3861-9. 2000.
129. T. Nakagawa, M. Setou, D. Seog, K. Ogasawara, N. Dohmae, K. Takio, and N. Hirokawa.
A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane
through direct interaction with AP-1 complex. Cell 103(4): 569-81. 2000.
130. S. Terada and N. Hirokawa.Moving on to the cargo problem of microtubule-dependent motors
in neurons. Current Opinion in Neurobiology 10(5): 566-73. 2000.
131. N. Hirokawa and Y. Noda.Preparation of recombinant kinesin superfamily proteins using the
baculovirus system. Methods in Molecular Biology (Clifton, N.J.) 164: 57-63. 2001.
132. M. Kikkawa, E. P. Sablin, Y. Okada, H. Yajima, R. J. Fletterick, and N. Hirokawa.
Switch-based mechanism of kinesin motors. Nature 411(6836): 439-45. 2001.
133. C. Zhao, J. Takita, Y. Tanaka, M. Setou, T. Nakagawa, S. Takeda, H. W. Yang, S. Terada, T.
Nakata, Y. Takei, M. Saito, S. Tsuji, Y. Hayashi, and N. Hirokawa.Charcot-Marie-Tooth
disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell 105(5): 587-97.
2001.
134. H. Miki, M. Setou, K. Kaneshiro, and N. Hirokawa.All kinesin superfamily protein, KIF,
genes in mouse and human. Proceedings of the National Academy of Sciences of the United
States of America 98(13): 7004-11. 2001.
135. J. Teng, Y. Takei, A. Harada, T. Nakata, J. Chen, and N. Hirokawa.
Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth,
and microtubule organization. The Journal of Cell Biology 155(1): 65-76. 2001.
136. Y. Noda, Y. Okada, N. Saito, M. Setou, Y. Xu, Z. Zhang, and N. Hirokawa.
KIFC3, a microtubule minus end-directed motor for the apical transport of annexin
XIIIb-associated Triton-insoluble membranes. The Journal of Cell Biology 155(1): 77-88.
2001.
137. Kazuo Nakajima, Yosuke Takei, Yosuke Tanaka, Terunaga Nakagawa, Takao Nakata,
Yasuko Noda, Mitsutoshi Setou, and Nobutaka Hirokawa.Molecular motor KIF1C is not
essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic
reticulum transport. Molecular and Cellular Biology 22(3): 866-73. 2002.
138. Mitsutoshi Setou, Dae-Hyung Seog, Yosuke Tanaka, Yoshimitsu Kanai, Yosuke Takei,
Masahiko Kawagishi, and Nobutaka Hirokawa.Glutamate-receptor-interacting protein GRIP1
directly steers kinesin to dendrites. Nature 417(6884): 83-7. 2002.
139. Ying Xu, Sen Takeda, Takao Nakata, Yasuko Noda, Yosuke Tanaka, and Nobutaka Hirokawa.
Role of KIFC3 motor protein in Golgi positioning and integration. The Journal of Cell Biology
158(2): 293-303. 2002.
140. Akihiro Harada, Junlin Teng, Yosuke Takei, Keiko Oguchi, and Nobutaka Hirokawa.
MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal
transduction. The Journal of Cell Biology 158(3): 541-9. 2002.
141. Richard Wing-Chuen Wong, Mitsutoshi Setou, Junlin Teng, Yosuke Takei, and Nobutaka
Hirokawa.Overexpression of motor protein KIF17 enhances spatial and working memory in
transgenic mice. Proceedings of the National Academy of Sciences of the United States of
America 99(22): 14500-5. 2002.
142. Yosuke Tanaka and Nobutaka Hirokawa.Mouse models of Charcot-Marie-Tooth disease.
Trends in Genetics : TIG 18(12): S39-44. 2002.
143. Betina Macho, Stefano Brancorsini, Gian Maria Fimia, Mitsutoshi Setou, Nobutaka Hirokawa,
and Paolo Sassone-Corsi.CREM-dependent transcription in male germ cells controlled by a
kinesin. Science 298(5602): 2388-90. 2002.
144. Y. Okazaki, M. Furuno, T. Kasukawa, J. Adachi, H. Bono, S. Kondo, I. Nikaido, N. Osato, R.
Saito, H. Suzuki, I. Yamanaka, H. Kiyosawa, K. Yagi, Y. Tomaru, Y. Hasegawa, A. Nogami, C.
Schönbach, T. Gojobori, R. Baldarelli, D. P. Hill, C. Bult, D. A. Hume, J. Quackenbush, L. M.
Schriml, A. Kanapin, H. Matsuda, S. Batalov, K. W. Beisel, J. A. Blake, D. Bradt, V. Brusic, C.
Chothia, L. E. Corbani, S. Cousins, E. Dalla, T. A. Dragani, C. F. Fletcher, A. Forrest, K. S.
Frazer, T. Gaasterland, M. Gariboldi, C. Gissi, A. Godzik, J. Gough, S. Grimmond, S.
Gustincich, N. Hirokawa, I. J. Jackson, E. D. Jarvis, A. Kanai, H. Kawaji, Y. Kawasawa, R. M.
Kedzierski, B. L. King, A. Konagaya, I. V. Kurochkin, Y. Lee, B. Lenhard, P. A. Lyons, D. R.
Maglott, L. Maltais, L. Marchionni, L. McKenzie, H. Miki, T. Nagashima, K. Numata, T.
Okido, W. J. Pavan, G. Pertea, G. Pesole, N. Petrovsky, R. Pillai, J. U. Pontius, D. Qi, S.
Ramachandran, T. Ravasi, J. C. Reed, D. J. Reed, J. Reid, B. Z. Ring, M. Ringwald, A.
Sandelin, C. Schneider, C. A. M. Semple, M. Setou, K. Shimada, R. Sultana, Y. Takenaka, M.
S. Taylor, R. D. Teasdale, M. Tomita, R. Verardo, L. Wagner, C. Wahlestedt, Y. Wang, Y.
Watanabe, C. Wells, L. G. Wilming, A. Wynshaw-Boris, M. Yanagisawa, I. Yang, L. Yang, Z.
Yuan, M. Zavolan, Y. Zhu, A. Zimmer, P. Carninci, N. Hayatsu, T. Hirozane-Kishikawa, H.
Konno, M. Nakamura, N. Sakazume, K. Sato, T. Shiraki, K. Waki, J. Kawai, K. Aizawa, T.
Arakawa, S. Fukuda, A. Hara, W. Hashizume, K. Imotani, Y. Ishii, M. Itoh, I. Kagawa, A.
Miyazaki, K. Sakai, D. Sasaki, K. Shibata, A. Shinagawa, A. Yasunishi, M. Yoshino, R.
Waterston, E. S. Lander, J. Rogers, E. Birney, Y. Hayashizaki, FANTOM Consortium, and
RIKEN Genome Exploration Research Group Phase I & II Team. Analysis of the mouse
transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420(6915):
563-73. 2002.
145. Nobutaka Hirokawa and Reiko Takemura.Kinesin Superfamily Proteins. In "Molecular
Motors" Manfred Schliwa editor. Wiley-VCH, Weinheim. 79-109. 2002.
146. Laurent Guillaud, Mitsutoshi Setou, and Nobutaka Hirokawa.
KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. The Journal of
Neuroscience : 23(1): 131-40. 2003.
147. Stefano Gustincich, Serge Batalov, Kirk W. Beisel, Hidemasa Bono, Piero Carninci, Colin F.
Fletcher, Sean Grimmond, Nobutaka Hirokawa, Erich D. Jarvis, Tim Jegla, Yuka Kawasawa,
Julianna LeMieux, Harukata Miki, Elio Raviola, Rohan D. Teasdale, Naoko Tominaga, Ken
Yagi, Andreas Zimmer, Yoshihide Hayashizaki, Yasushi Okazaki, RIKEN GER Group, and
GSL Members.Analysis of the mouse transcriptome for genes involved in the function of the
nervous system. Genome Res 13(6B): 1395-401. 2003.
148. Harukata Miki, Mitsutoshi Setou, Nobutaka Hirokawa, RIKEN GER Group, and GSL
Members.Kinesin superfamily proteins (KIFs) in the mouse transcriptome. Genome Res 13(6B):
1455-65. 2003.
149. Noriko Homma, Yosuke Takei, Yosuke Tanaka, Takao Nakata, Sumio Terada, Masahide
Kikkawa, Yasuko Noda, and Nobutaka Hirokawa.Kinesin superfamily protein 2A (KIF2A)
functions in suppression of collateral branch extension. Cell 114(2): 229-39. 2003.
150. Yasushi Okada, Hideo Higuchi, and Nobutaka Hirokawa.Processivity of the single-headed
kinesin KIF1A through biased binding to tubulin. Nature 424(6948): 574-7. 2003.
151. Takao Nakata and Nobutaka Hirokawa.Microtubules provide directional cues for polarized
axonal transport through interaction with kinesin motor head. The Journal of Cell Biology
162(6): 1045-55. 2003.
152. Nobutaka Hirokawa and Reiko Takemura.Biochemical and molecular characterization of
diseases linked to motor proteins. Trends in Biochemical Sciences 28(10): 558-65. 2003.
153. Tadayuki Ogawa, Ryo Nitta, Yasushi Okada, and Nobutaka Hirokawa.A common mechanism
for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the
class-specific neck and loops. Cell 116(4): 591-602. 2004.
154. Ryo Nitta, Masahide Kikkawa, Yasushi Okada, and Nobutaka Hirokawa.
KIF1A alternately uses two loops to bind microtubules. Science 305(5684): 678-83. 2004.
155. Yoshimitsu Kanai, Naoshi Dohmae, and Nobutaka Hirokawa.Kinesin transports RNA:
isolation and characterization of an RNA-transporting granule. Neuron 43(4): 513-25. 2004.
156. Naoko Mizuno, Shiori Toba, Masaki Edamatsu, Junko Watai-Nishii, Nobutaka Hirokawa,
Yoko Y. Toyoshima, and Masahide Kikkawa.Dynein and kinesin share an overlapping
microtubule-binding site. The EMBO Journal 23(13): 2459-67. 2004.
157. Nobutaka Hirokawa and Reiko Takemura.Molecular motors in neuronal development,
intracellular transport and diseases. Current Opinion in Neurobiology 14(5): 564-73. 2004.
158. Nobutaka Hirokawa and Reiko Takemura.Kinesin superfamily proteins and their various
functions and dynamics. Experimental Cell Research 301(1): 50-9. 2004.
159. Nobutaka Hirokawa and Reiko Takemura.Molecular motors and mechanisms of directional
transport in neurons. Nature Reviews Neurosci 6(3): 201-14. 2005.
160. Junlin Teng, Tatemitsu Rai, Yosuke Tanaka, Yosuke Takei, Takao Nakata, Motoyuki
Hirasawa, Ashok B. Kulkarni, and Nobutaka Hirokawa.The KIF3 motor transports N-cadherin
and organizes the developing neuroepithelium. Nat Cell Biol 7(5): 474-82. 2005.
161. Yosuke Tanaka, Yasushi Okada, and Nobutaka Hirokawa.FGF-induced vesicular release of
Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.
Nature 435(7039): 172-7. 2005.
162. Yasushi Okada, Sen Takeda, Yosuke Tanaka, Juan-Carlos Izpisúa. Belmonte, and Nobutaka
Hirokawa.Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis
determination. Cell 121(4): 633-44. 2005.
163. Harukata Miki, Yasushi Okada, and Nobutaka Hirokawa.Analysis of the kinesin superfamily:
insights into structure and function. Trends in Cell Biology 15(9): 467-76. 2005.
164. Chien CL, Lu KS, Lin YS, Hsieh CJ, Hirokawa N. The functional cooperation of MAP1A
heavy chain and light chain 2 in the binding of microtubules. Exp Cell Res.2005 Aug
15;308(2):446-58. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama
R,Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE,Batalov S,
Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE,Ambesi-Impiombato A,
Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L,Beisel KW, Bersano T, Bono H,
Chalk AM, Chiu KP, Choudhary V, Christoffels A,Clutterbuck DR, Crowe ML, Dalla E,
Dalrymple BP, de Bono B, Della Gatta G, diBernardo D, Down T, Engstrom P, Fagiolini M,
Faulkner G, Fletcher CF, FukushimaT, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P,
Gingeras TR, Gojobori T,Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK,
Hirokawa N, Hill D,Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin
A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger
A,Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S,
McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, MikiH,
Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P,
Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y,Orlando V, Pang KC,
Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M,
Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple
CA, Seno S, Sessa L, Sheng Y, Shibata Y,Shimada H, Shimada K, Silva D, Sinclair B, Sperling
S, Stupka E, Sugiura K,Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor
MS, Tegner J,Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K,
Yamanishi H,Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD,
Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki
D,Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida
J,Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S,
Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, ShirakiT, Suzuki
S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J,Hayashizaki Y;
FANTOM Consortium; RIKEN Genome Exploration Research Group andGenome Science
Group (Genome Network Project Core Group). The transcriptionallandscape of the mammalian
genome. Science. 2005 Sep 2;309(5740):1559-63
165. Hirokawa N, Tanaka Y, Okada Y, Takeda S. Nodal flow and the generation ofleft-right
asymmetry. Cell. 2006 Apr 7;125(1):33-45. Review.
166. Midorikawa R, Takei Y, Hirokawa N. KIF4 motor regulates activity-dependent neuronal
survival by suppressing PARP-1 enzymatic activity. Cell. 2006 Apr21;125(2):371-83.
167. Hirokawa N. mRNA transport in dendrites: RNA granules, motors, and tracks. J Neurosci.
2006 Jul 5;26(27):7139-42. Review.
168. Kikkawa M, Hirokawa N. High-resolution cryo-EM maps show the nucleotide binding pocket
of KIF1A in open and closed conformations. EMBO J. 2006 Sep 20;25(18):4187-94.
169. Oda T, Hirokawa N, Kikkawa M. Three-dimensional structures of the flagellar
dynein-microtubule complex by cryoelectron microscopy. J Cell Biol. 2007 Apr23;177(2):
243-52.
170. Guillaud L, Wong R, Hirokawa N. Disruption of KIF17-Mint1 interaction by
CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release. Nat Cell Biol.
2008 Jan;10(1):19-29.
171. Hirokawa N, Noda Y. Intracellular transport and kinesin superfamily proteins, KIFs: structure,
function, and dynamics. Physiol Rev. 2008 Jul;88(3):1089-118.
172. Nitta R, Okada Y, Hirokawa N. Structural model for strain-dependent microtubule activation
of Mg-ADP release from kinesin. Nat Struct Mol Biol. 2008 Oct;15(10):1067-75.
173. Niwa S, Tanaka Y, Hirokawa N. KIF1Bbeta- and KIF1A-mediated axonal transportof
presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.Nat
Cell Biol. 2008 Nov;10(11):1269-79.
174. Okada Y, Hirokawa N. Observation of nodal cilia movement and measurement of nodal flow.
Methods Cell Biol. 2009;91:265-85.
175. Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and
intracellular transport. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96.
176. Zhou R, Niwa S, Homma N, Takei Y, Hirokawa N. KIF26A is an unconventional kinesin and
regulates GDNF-Ret signaling in enteric neuronal development. Cell. 2009 Nov
13;139(4):802-13.
177. Hirokawa N, Nitta R, Okada Y. The mechanisms of kinesin motor motility:lessons from the
monomeric motor KIF1A. Nat Rev Mol Cell Biol. 2009 Dec;10(12):877-84.Terada S, Kinjo M,
Aihara M, Takei Y, Hirokawa N. Kinesin-1/Hsc70-dependent mechanism of slow axonal
transport and its relation to fast axonal transport.EMBO J. 2010 Feb 17;29(4):843-54.
178. Hirokawa N, Niwa S, Tanaka Y. Molecular motors in neurons: transport mechanisms and
roles in brain function, development, and disease. Neuron. 2010 Nov 18;68(4):610-38.
179. Ueno H, Huang X, Tanaka Y, Hirokawa N. KIF16B/Rab14 molecular motor complex is
critical for early embryonic development by transporting FGF receptor. Dev Cell. 2011 Jan
18;20(1):60-71.
180. Yin X, Takei Y, Kido MA, Hirokawa N. Molecular motor KIF17 is fundamental for memory
and learning via differential support of synaptic NR2A/2B levels. Neuron. 2011 Apr
28;70(2):310-25.
181. Nakata T, Niwa S, Okada Y, Perez F, Hirokawa N. Preferential binding of a kinesin-1 motor
to GTP-tubulin-rich microtubules underlies polarized vesicle transport. J Cell Biol. 2011 Jul
25;194(2):245-55.
182. Noda Y, Niwa S, Homma N, Fukuda H, Imajo-Ohmi S, Hirokawa N.Phosphatidylinositol
4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin,
KIF2A and suppresses elongation of axon branches. Proc Natl Acad Sci U S A. 2012 Jan
31;109(5):1725-30.
183. Hirokawa N, Tanaka Y, Okada Y. Cilia, KIF3 molecular motor and nodal flow.Curr Opin
Cell Biol. 2012 Feb;24(1):31-9.
184. Kondo M, Takei Y, Hirokawa N. Motor protein KIF1A is essential for hippocampal
synaptogenesis and learning enhancement in an enriched environment. Neuron. 2012.Feb
23;73(4):743-57.
185. Yin X, Feng X, Takei Y, Hirokawa N. Regulation of NMDA receptor transport: a
KIF17-cargo binding/releasing underlies synaptic plasticity and memory in vivo. J Neurosci.
2012 Apr 18;32(16):5486-99.
186. Yajima H, Ogura T, Nitta R, Okada Y, Sato C, Hirokawa N. Conformational changes in
tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy. J Cell
Biol. 2012 Aug 6;198(3):315-22.
187. Zhou R, Niwa S, Guillaud L, Tong Y, Hirokawa N. A molecular motor, KIF13A,controls
anxiety by transporting the serotonin type 1A receptor. Cell Rep. 2013.Feb 21;3(2):509-19.
188. Chang Q, Nitta R, Inoue S, Hirokawa N. Structural Basis for the ATP-Induced Isomerization
of Kinesin. J Mol Biol. 2013 Mar 7. doi:pii: S0022-2836(13)00151-4.
189. Niwa S, Takahashi H, Hirokawa N. β-Tubulin mutations that cause severe neuropathies
disrupt axonal transport. EMBO J. 2013 Mar 15. doi:10.1038/emboj.2013.59.