Scheme of Work 2010 / 2011 THINK ACTIVE! WHAT ARE THE LEARNERS DOING? Module / Unit Title: A2 Human Biology Prepared by: Sue Brown Lesson Duration: Three sessions – one 2 hour and 2 x 1.5 hours. Start Date: 9th September 2009 End Date: 28th May 2010 D:\106758999.doc Course Overview: This course is taught by Sue Brown in 5 hours per week. Each section represents one week of three lessons. Learning Outcomes: Learners need to be coached in exam technique and Practical skills as well as acquiring knowledge and understanding of the different topics. Assessment Details: HBIO4 will be examined on Monday 24th January 2011. (1.30pm) HBIO5 will be examined on Wednesday 22nd June 2011. (1.30pm) HBIO6 is the Coursework – this will be carried out in Spring Term. Any AS unit re-sits are possible in January and/or June. Date What topic(s) and learning objectives will be covered? What will learners do? How will learning be checked? ECM 13/9/10 One 2 hour lesson for Induction to A2 Subject ILPs. (one 2 lesson) Identify need for ALS. Agree a plan to re-sit Coursework unit. Begin recap of structure of DNA and RNA. Discussions about re-sits and expectations for the A2 year. Mini test on AS topics. ECM 5 (achieving – careers & HE progressio n) 20/9/10 Identify free time on timetables for ALS. Q & A to individuals. Fun Recap of DNA structure using “DNA Millionnaire” game on power point. 3.4.3. The management structure of cells – DNA and protein synthesis Be able to describe protein synthesis, to include the transcription of DNA, processing of mRNA, and the roles of D:\106758999.doc Sheet to capture free blocks for ALS. Independen t Learning/ Homework Revision of AS topics – initially of DNA & RNA structure in prep for next week’s topic. Mini white boards PROTEIN SYNTHESIS. Be able to explain that the genetic code is a triplet, universal, nonoverlapping and degenerate code What resource s are needed? Subject ILPs for A2 year. Note down the 3 characteristics of the Genetic code with explanations and learn these for test next week. Use ‘constructivist’ method to work out how it might happen – in groups of 2 or 3. Use drawings to speculate. Whole group to compare ideas Individually – write description of transcription in own words as if a six mark exam question. (SB to collect & mark) Do same for translation. (SB to collect & mark) Facilitating around room Protein synthesis booklets. ECM 5 – improving exam technique Animation on Blackboar d under HBIO4. Revise AS material on basics of how genes make proteins. mRNA, tRNA and ribosomes in translation Hand out Protein Synthesis booklets to further summarise. Recap and overlay this topic which many find difficult to understand. and then see actual process by watching animation on Blackboard. Followed by discussion and questions to clarify. and confirming answers. Teacher facilitates asking Q & A. Exam Qs on Protein Synthesis. Complete gaps in protein synthesis booklet in class. In groups of 2 or 3, recap topic by making posters to explain Protein Synthesis to class. Use a real DNA code to demonstrate which polypeptide chain would be produced by using the table of codes in the booklet to practice understanding of this. Describe own poster to peers (teacher facilitates by asking stretching questions). ECM 4 – positive contributio n. Small groups gather around each table to hear and comment on the explanation. Peer evaluation – adding more comments and correcting any mistakes. GENE REGULATION Understand that the protein formed could be D:\106758999.doc Recap: characteristics of the genetic code. Hand in protein synthesis homework. Prepare the 4 actual DNA codes to use for each group. Bb site ECM 3 (enjoying) Fun recap: Singalong a Protein Synthesis 27/9/10 Poster paper, glue, card, scissors, felt tip pens. Marking of protein synthesis homework questions. Write lists individually Mini white boards Must do 1- 4, Should do 5, 6 and 7. Could do 8. an enzyme, a receptor or a structural protein Be able to understand that transcription of specific genes is regulated. Be able to explain how increased methylation of the DNA or decreased acetylation of associated histones represses transcription. Be able to explain that some substances bind to receptor molecules inside the cytoplasm, using the steroid hormone testosterone as an example of how it forms a complex with its receptor that initiates transcription Understand that gene mutation can lead to the formation of a nonfunctional protein, using D:\106758999.doc Write down as many examples of proteins as you can think of. Share with group on whiteboard. Then categorise into types on board by Q & A. Write down the summary. from previous knowledge. Q & A of examples put onto board and Qs to individuals to categorise. ECM 4 – positive contributio n Textbooks Comprehension exercise - make notes in own words from 75 & 76. Include testosterone and methyl & acetyl groups. SB to facilitate and ask Qs as they do this. 5 Q test at start of lesson 2. Recap test on acetylation and methylation. Produce diagrammatic summary to make more sense of this. Relate to new information and current research on Epigenetics. Show website: www.epigenome.eu Produce annotated drawings to represent how hormones can switch genes on and trigger transcription. Q & A to relate back to protein structure and importance of shape (receptors). Link to AS by Q & A about cystic Mini-test about fibrosis to check re-call and apply symptoms and causes of new knowledge. Cystic Fibrosis. Complete notes on gene regulation and summarise for homework. Prepared test. Link set up to website to show class. ECM 1 – being healthy – re lifestyle & disease. Visit www.epigeno me.eu to investigate more about Epigenetics. Revise Cystic Fibrosis (as an example of genes going wrong) Revise Cancer from the CFTR protein in cystic fibrosis as an example. CANCER Be able to recall the differences between benign and malignant tumours from their AS study Study skills – questioning shock headlines. Is data valid? Give examples of recent news items to discuss. 04/10/1 0 Be able to explain the role of tumour suppressor genes and oncogenes in controlling the cell cycle AS. Write down the difference between malignant and benign tumours. Further Q & A to recap AS level of knowledge on metastasis etc. Individually list 5 and List as many causes of cancer as read out one each by possible. At least 5 each – then directed Q & A. add to board list for class to share. Discussion of causes – Class discussion of the causes of are they proven by valid various cancers resulting in each research etc. student choosing a possible cause and effect to research for homework. Recap: Clarify roles of these genes under normal conditions – make extra notes on this to build on AS. Be able to explain how abnormal methylation of tumour suppressor genes and oncogenes can lead to the development of tumours Apply knowledge from last week to predict effect of methylation and acetylation. Be able to explain that increased oestrogen Notes on effect of oestrogen and how tamoxifen works. D:\106758999.doc Mini white boards ECM 1 & 2: safe & healthy re lifestyle choices and raising awareness of carinogens Summarise roles when working normally. Research a chosen type of cancer and research to get data that shows causal links. Mini white boards Visit national Cancer Institute website at Suggest effects using a flow chart. Explain in own words why tamoxifen is effective. ECM 1 – healthy. Textbook p78 http://www.c ancer.gov/ca ncertopics/u concentrations are involved in the development of some breast cancers Be able to evaluate evidence showing correlations between environmental factors and various forms of cancer Be able to explain that a correlation does not prove a causal link, and that further experimental investigation is required to establish any causal link Use collected data researched by class to evaluate more examples of correlations. Subject ILP reviews for end of September. 11/10/1 0 Recap to date Enzymes control the rate of reactions in cells D:\106758999.doc Look at graph showing link between alcohol & breast cancer on page 79. Describe the trends in the graph. Answer questions on page 79 of Calculate percentage textbook. Including data-handling increase in risk. exercises to calculate percentage change. Look at Graphs showing Age relating to Prostate Cancer and to Breast Cancer on pages 39 and 40. nderstanding cancer/canc er ECM 1 & 2 – staying safe. Mini white boards Evaluate whether this data proves a cause and effect. Draw 3 conclusions from each graph. Compare researched data and analyse and evaluate the data to draw conclusions. Share conclusions with whole group and discuss validity of conclusions. Share research data from homework and write succinct statements to draw conclusions. Reflect on strengths and weaknesses to date. 1:1 discussion with teacher about progress to date and decisions 1:1 discussion about about January re-sits. progress and actions to improve performance. End of September test covering all of the above. Written test to complete under exam conditions. Mark the 12 question test. Photocopi ed data brought in by the class to analyse. ECM 5 – economic wellbeing – aiming for grades needed for HE place. ECM 5 – economic Use info there to practise interpreting and criticising data. Revise work done to date. Paper test with 12 Qs including some data Understand that enzymes coded for by DNA control cellular Reactions Be able to explain how the end-product of a series of reactions can influence the reaction by inhibiting the enzyme, or repressing transcription of a gene. 3.4.4. New genes for old – recombinant DNA Be able to explain how recombinant DNA is produced Understand how recombinant DNA is transferred, including the role of plasmids as vectors; ligases; and genetic markers to identify genetically modified organisms. Be able to explain how sticky ends are produced D:\106758999.doc Recap of Enzymes – state all Directed Q & A knowledge of enzymes learned in Gather info by class AS by directed Q & A. thought shower onto board. Students consider and suggest ways in which enzymes can be Suggestions on miniregulated – relate to last week’s whiteboards. topic & last year’s info. Share ideas. Summarise outcomes as a whole Answer Qs on p81 group. Then take notes from p80 & 81. Use ‘constructivist’ method to work out how this occurs. Gather ideas and develop these by Q & A. Watch animations on Blackboard. Complete booklet questions at intervals. wellbeing – aiming for grades needed for HE place. analysis. Miniwhiteboar ds. Textbooks Essays on gene technology. ECM 3: fun Textbooks warm up. Blackboar d site. Gene technolog y booklets Demonstration of techniques using plasticine. Explain model of recombinant DNA to peers. ECM 3: enjoy the plasticine Plasticine. Complete answers to questions in Gene Technology booklet. Frequent review. In a nutshell sheets. Homework pack on Gene Technology exam questions from Be able to explain how genes may be isolated by making the gene in a ‘gene machine’; creating the gene from mRNA; or using restriction enzymes to cut the gene from DNA 18/10/1 0 Posters to summarise. Explain poster summaries of recombinant DNA. ECM 3 – most enjoy posters Be able to explain the use of gene probes Understand the role of gene libraries Be able to evaluate whether selective breeding is ethically different from the use of modern gene technologies Be able to describe how selective breeding programmes have been used to create new strains and species of crop plants D:\106758999.doc Blackboard. Qs 1, 2, 3, 4 and 6 Exam Qs for homework. Genetically modified organisms Be able to explain how the polymerase chain reaction produces larger quantities of DNA Poster paper & felt pens. Textbooks Watch Bb Animation of PCR Students research the role of gene libraries Watch Bb animation of gel electrophoresis. Mini white boards Construct a flowchart of stages of PCR. Bb animation Explain how gene probes are used to isolate genes 3 mark Q. Poster paper & pens. Students research the role of gene libraries and watch www.yourgenome.org Class discussion about selective breeding and gene technology Students research new strains and species of organisms produced using gene technology, and evaluate their uses Discuss ethics of selective breeding vs gene technology. ECM 3 – enjoy discussion Use of ICT. Exam Qs for homework. Homework pack on Gene Technology exam questions from Blackboard. Qs 5, 7 and 8. Be able to describe the use of gene technology in producing GM organisms, to include herbicide-resistant crop plants and cattle with high milk yields Be able to discuss moral and ethical issues relating to the production of GM organisms, to include ownership of genes; ownership of the modified organisms; and financial benefits 25/10/1 0 01/11/1 0 Market place activity to share info about Selective Breeding, Students discuss Human Genome, Malaria advantages and vaccines and Uses in Farming. disadvantages of each one. Debate for and against uses of Gene Technology. ECM 4 – making a contributio Textbooks n to class and knowledge. Internet. Poster paper & pens. Cary out research to prepare for Debate either for or against Gene Technology. Monitor accuracy of points made in debate. Encourage counterarguments. ECM 3 & 4 Be able to evaluate the concept of sanctity of the species HALF TERM Genome projects, what they tell us and what they don’t Know that the human genome has been sequenced Textbooks Watch “How the Genome was worked out” animation on Bb & discuss. Be aware of non-coding DNA and regulatory genes Research and report on the Human Genome and its potential uses. Vaccines may be D:\106758999.doc ECM 3 Explain why the DNA nucleotide sequences cannot be translated into a list of genes coding for proteins – reference to non-coding DNA & regulatory genes Mini white boards Internet. Research on recommende d websites. produced against pathogens using the proteome of simpler organisms. 08/11/1 0 Understand the work of the Sanger Institute in producing a vaccine against Plasmodium 3.4.5. Drugs can affect how we perceive the world around us – neurones and nerve impulses Be able to describe the structure of myelinated sensory and motor neurones Understand the role of the neurone membrane in maintaining a resting potential; initiating an action potential and its all-or-nothing nature; and the passage of an action potential along non-myelinated and myelinated axons resulting in nerve impulses. D:\106758999.doc Students look at the information available on the website of the Sanger Institute at Discussion of outcomes. http://www.sanger.ac.uk/humgen/ Watch introductory animation on Bb. Discuss CNS and PNS and the circuit of connections. Assess prior learning using mini whiteboards. Mini white boards Write down 6 receptors. Model of spinal cord in spine. Complete pages 3 & 4 of Nervous system booklet. Nervous system booklet. Show model of spinal cord. Students make models of neurones using plasticine and drinking straws – particularly useful to show how Schwann cells form the myelin sheath Students describe the differences between sensory and motor as asked by Q & A. ECM 3 (enjoy using plasticine) Plasticine & drinking straws. Show the Animations on Bb – Action Complete pages 5, 6 & 7 Potential 1 & 2 and channel gates. of booklet. Homework: Students produce summary information on a revision poster. Dominoes to illustrate the wave of depolarisation passing along a nerve axon. Dominos Explain summary posters to each other. ECM 4 Discuss threshold re all or nothing. Nervous System exam pack Q 1 & 2. Understand the nature and importance of the refractory period in producing discrete nerve impulses Understand the relationship between intensity of stimulation, size of generator potential and frequency of action potentials 15/11/1 0 Use movement of cardboard ions on posters to explain why there has to be a refractory period. Suggest and then discuss how intensity is conveyed in small groups. Show and explain their moving models to explain refractory period. Complete pages 8, 9 & 10. Synapses where neurones communicate Homework: Nervous system booklet. Watch animation of synapse on Bb. Be able to describe the structure of a synapse as revealed by the electron microscope Be able to describe the sequence of events involved in the action of a cholinergic synapse and a neuromuscular junction Make a poster to show structure. Use cardboard ions to demonstrate changes during and after synaptic transmission. Make moving models with ions to show action at synapse & describe this. ECM 3 ECM 4 Summarise as a 6 mark exam Q and peer mark. Perception and Drugs Be able to describe the effect of drugs on a synapse Show useful website for effect of various drugs on the brain. Be able to predict and http://faculty.washington.edu/chudle D:\106758999.doc emicrograp hs of synapse. Exam question pack on the Nervous System Qs 3, 4 & 5. Must, Should, Could on page 17 of booklet: Produce a report summarising effects of ECM 1 Students research the effect of drugs on the nervous system, e.g. using the neuroscience explain the effects of specific drugs on a synapse, when provided with information r/neurok.html drugs on the brain for kids website Be able to understand the functioning of the nervous system, in order to appreciate the processes between sensation, the detection of stimuli, and perception due to processing and interpretation by the brain Be able to use their knowledge of the functioning of the nervous system to explain how drugs can influence the functioning of the brain and so affect mood and perception of reality Be able to explain that LSD and cocaine affect the actions of monoamine transmitters; marijuana binds to THC receptors, and nicotine binds to nicotinic receptors in the brain and sympathetic ganglia D:\106758999.doc Students compare different parts of the skin in terms of sensitivity to stimuli (apply two points of a pair of dividers or one end to the skin, and the student has to say whether they can detect one or two points) Students research the effect of drugs on the nervous system, e.g. using the neuroscience for kids website at http://faculty. washington.e du/chudler/ne urok.html 22/11/1 0 The EYE Perceptions and the Brain Be able to describe the structure of a human eye and its transmissive and refractive properties in focusing an image on the retina Be able to explain the role of rod cells and cone cells in effecting monochromatic and trichromatic vision Understand that the absorption of light by rhodopsin produces a chemical change leading to the creation of a generator potential (details of hyperpolarisation are not required) Be able to explain how the connections between sensory cells and the neurones of the optic nerve allow sensitivity and acuity of vision Describe how the nerve pathways from the eye to the brain (optic nerve, D:\106758999.doc See Neuroscience for kids website http://faculty.washington.edu/chudle r/smartd.html Video 44 – New Living Body – Senses (4.04 – 5.44) Video C11b includes Video:‘Nerves at Work’ (429) Dissection of an eye Investigation of models Model of the eye. Label the eye diagram. Draw in lines of light to show refraction. Video of Nerves at Work. Exam Q. on visual acuity and retinal convergence. Eye for dissection. Labelling diagrams Use of graphs showing wavelengths of light detected by the different cones to predict the colour perceived by the brain Colourblindness test cards or website such as http://www.toledobend.com/colorblin d/Ishihara.html Explain summation of nerve impulses to reach threshold. Test cards. Students compare their ability to read a newspaper in bright and dim light Investigation of optical illusions Students research these theories and present their findings Range of optical illusions. Homework: Exam question pack on Receptors. optic chiasma, lateral geniculate nucleus, demonstrate lateralisation and localisation of function in the brain Students handle data based on unfamiliar information Write a summary of top down vs bottom up perception theory. Understand the role of the brain in visual perception Produce a report of effects of drugs on the brain. Understand, in outline, the ‘top down’ and ‘bottom up’ theories of visual perception Bb site showing effects of difffernt drugs on the brian (Mouse game). Produce a report of effects of drugs on the brain. Be able to predict and explain the effects of specific drugs on perception, when provided with information 29/11/1 0 3.4.6. Fight or flight – anger and fear Understand that the nervous and hormonal systems work together D:\106758999.doc Poster paper. Discussion about how people react to threatening situations to describe the flight or flight response Pens. Blackboar Exam pack – questions on flight or flight response. to produce coordinated responses to stimuli which we perceive as threatening or frightening Be able to explain the roles of the hypothalamus, sympathetic nervous system and adrenal gland in bringing about the fight or flight response Be able to compare nervous and hormonal coordination, and appreciate why hormonal control (especially steroid hormone control) takes longer than nervous control Understand that stimuli perceived by the brain can lead to hormonal changes that produce physiological responses Understand the role of the hypothalamus in mediating such responses Be able to describe the D:\106758999.doc d power points. Students compare nervous and hormonal control by producing a table of comparisons Produce a table comparing hormonal and nervous responses. Annotate diagrams showing effects of sympathetic and parasympathetic systems on various organs Give examples of flight or fight responses. Annotation of suitable diagrams Produce a poster summarising effects of sympathetic vs parasympathetic nervous responses. general role of the sympathetic and parasympathetic components of the autonomic nervous system and their antagonistic effects The role of the hormonal system Be able to explain how the hypothalamus receives input from the cerebral cortex; and sends impulses via the sympathetic nervous system to effectors, which may be muscles or glands (as exemplified by the adrenal glands) Be able to describe how information is transferred by hormones released by endocrine glands which affect the physiological activities of target cells Be able to describe the physiological actions of adrenaline D:\106758999.doc 06/12/1 0 Muscle Contraction Be able to describe movement and maintenance of posture in terms of antagonistic muscle action Understand the gross and microscopic structure of skeletal muscle, and the ultrastructure of a myofibril Be able to explain the sliding filament theory of muscle contraction Be able to describe the roles of actin, myosin, calcium ions and ATP in muscle contraction Understand that muscles are effectors Be able to describe the structure, location and general properties of slow and fast skeletal muscle fibres Label diagrams of muscle pairs. Whilst looking at diagrams of antagonistic muscle pairs, students try the movements and feel which muscles are contracting in their own body Given a picture of a joint, students predict the position of antagonistic muscle pairs used to move the joint Students examine electron micrographs of muscle tissue Students make paper models to understand the sliding filament theory – can be done using bendy drinking straws Make models of sliding filament theory using straws and describe to peer group. Microscop e slides of muscle structure. Muscles Booklet. Complete tables and missing words. Video 33 – New Living Body – Muscles(7.03 – 9.03 mins and 12.05-13.35) Power point on muscles. Pictures of elbow and knee joints. Annotate diagrams Make a model of sliding filaments D:\106758999.doc Observe e micrographs of muscle structure and make observational notes. Muscles booklet. Make a table to compare slow twitch and fast twitch muscles, giving examples of both. Video on Muscles. Straws to Homework: Exam question pack on Muscles. using straws. Video A20 New Living body – Muscles. 13/12/1 0 3.4.1. IVF – reproduction and contraception Be familiar with the male and female reproductive systems in sufficient detail to understand: the structure of the seminiferous tubules and ovaries; the roles of mitosis and meiosis in spermatogenesis and oogenesis, emphasising differences between spermatogenesis and oogenesis Understand the importance of copulation and fertilisation – capacitation, acrosome reaction, formation of second polar body, fusion of nuclei and formation of a fertilisation membrane; formation of the blastocyst and its implantation; development of the placenta – its structure and role in transfer of D:\106758999.doc Use of models and video to show these events SSER Powerpoints for Human Biology ‘Gametes and Fertilisation’ www.sserltd.co.uk The rest of set 8 in this series would be useful for this topic Label male and female diagrams of reproductive organs. Produce a table comparing oogenesis to spermatogenesis. Students produce summary posters Students observe stages of meiosis and compare them with mitosis Produce a table to compare mitosis and meiosis. Produce a poster summarising fertilisation. make models of sliding filament theory. Video. Booklets of reproducti on. Homework pack of exam questions on reproduction. material between embryo and mother. Understand the processes of birth and lactation Describe the hormonal control of reproduction in females, including the role of FSH, LH, oestrogen and progesterone in the menstrual cycle Describe the role of hCG and progesterone in maintaining a pregnancy Describe the role of progesterone and oxytocin concentrations in initiating labour Describe the role of oxytocin and prolactin in milk production, including positive feedback controlling the secretion of oxytocin Understand the role of hormones in contraception Know condoms, IUD, cap and ‘morning after’ pills as examples of birth control mechanisms Be able to discuss the ethical and moral issues relating to the use of D:\106758999.doc How Science Works: how basic research into the mechanism of control of the menstrual cycle eventually led to the development of the contraceptive pill Students prepare leaflets to explain different forms of contraception to clients at a family planning clinic Discussion of social impact of contraception in the UK Role play of doctor at IVF clinic and couple seeking help Class discussion on ethical and moral issues involving IVF – could also be done as a TV discussion programme with students in different roles, e.g. lesbian couple wanting IVF to have a baby; a woman whose oviducts are blocked as a result of sexually transmitted diseases acquired through previous promiscuity; etc. Produce a table summarising the main hormones involved in reproduction, pregnancy and lactation. Produce leaflets about contraception. Homework pack of exam questions on contraceptio n and IVF. different forms of contraception Be able to evaluate benefits and risks associated with different forms of contraception Know that low sperm count and blocked oviducts are causes of infertility Describe the use of IVF to treat women with blocked oviducts, to include the use of FSH to stimulate multiple ovulation; removal of the oocytes from the oviducts; fertilisation; culture to the 8-16 cell stage; and reimplantation of some of the embryos Be able to discuss the ethical and moral issues associated with IVF, including the fate of embryos that are not implanted; their possible use in scientific experiments; and the extent to which IVF should be available 20/12/1 0 27/12/1 0 04/1/11 Christmas Christmas 3.4.2. Growing up, growing old – D:\106758999.doc Data analysis of growth. Data Genetics patterns of human growth the effects of diseases and ageing Be able to describe the pattern of growth of the whole body, reproductive organs and brain from infancy to childhood Be able to describe puberty and the development of secondary sex characteristics in males and females. Explain the decline in physiological functions with age, to include basal metabolic rate (BMR); cardiac output; nerve conduction velocity; female reproductive capacity as a result of changes in concentrations of pituitary and ovarian hormones Understand that cancer and Alzheimer’s disease are associated with old age Be able to discuss the issues facing society in terms of the increasing numbers of elderly people in the population and treating diseases associated with old age. D:\106758999.doc showing growth rates etc. Students plot graphs and explain their shape exam Q pack. Produce posters to summarise main changes at Puberty. Students carry out horizontal studies of height, mass, and relative proportions of different parts of the body at different ages. Also comparing sex differences. Students select appropriate ways of displaying these data. Data analysis Students research incidence of these diseases with age. Class discussion – perhaps role play of a primary Health Trust discussing strategies to plan for the future. Write an essay describing changes that occur during ageing. Discussion about the increase in the aged population and social implications. Write an essay describing changes that occur during ageing. Be aware that many conditions needing treatment, or with the potential to need treatment, are inherited Understand the meaning of the terms gene, allele, genotype, phenotype, dominant, recessive, homozygous and heterozygous Understand that cystic fibrosis is an example of monohybrid inheritance, that sickle cell anaemia is an example of codminant alleles; that ABO blood groups are an example of inheritance involving multiple alleles Understand the Rhesus blood groups, and the potential dangers to a rhesus negative mother giving birth to rhesus positive babies Be able to give reasons why experimental results may only approximate to Mendelian ratios Be able to apply the chi-squared test to establish the significance of any differences from D:\106758999.doc Compile a list of main terms used in genetics with definitions. Students identify inherited conditions. Students predict results of genetic crosses. Students prepare a leaflet to inform pregnant women about the possible dangers of a rhesus negative woman having a rhesus positive baby. NOWGEN offer resources and practical activities http://nowgen.org.uk/page/index.php ?sid=4 Practice variety of genetics questions. Nature’s dice available from the NCBE at Reading University http://www.ncbe.reading.ac.uk/NCB E/PROTOCOLS/dice.html Students investigate data from genetic crosses and explain why they only approximate to Mendelian ratios – to include human pedigrees Students apply chi-squared test to genetic cross data Role-play between a genetic counsellor and parents who are at risk of having a baby with a particular condition such as CF Practice at Chi – squared calculations. predicted ratios. Know the role of a genetic counsellor Explain how information from family history and genetic screening can be used to advise parents Understand the screening of embryos Be able to consider the ethical and moral issues relating to genetic counselling Students investigate ways in which embryos are screened How Science Works: discussion about whether something should be done, just because it can be done. For example, should we test for conditions with no treatment? Who owns the results of genetic test? Implications for insurance, etc. Discussion about ethical and moral issues relating to genetic counselling – students could carry out a role play of a radio interview between a radio journalist, a parent seeking embryo screening and a pro-life activist. Students could carry out (or use second hand data from) Mendelian crosses with a suitable organism, eg fast-growing brassicas or Drosophila – analyse results using chi-squared. Students collect large amounts of data about a continuous feature, eg length of index finger. They collect class data together and plot a graph. They analyse the data to find the mean, median, mode and standard deviation. Analyse data about possible genetic predisposition to develop a disease or disorder, e.g. women with the BRCA1 or BRCA2 allele. D:\106758999.doc Discuss role of genetics councillor – role play. Discussion of ethical issues of genetic councelling. 10/1011 Understand the roles of the X and Y chromosomes in determining gender Know that Duchenne muscular dystrophy is a sex linked condition Be able to explain why sex linked conditions are rare in women Know that features showing discontinuous variation are categoric Understand that ABO blood groups are an example of discontinuous variation Understand that features showing continuous variation are often polygenic. They often produce a normal distribution, which can be described in terms of mean and standard deviation. Understand the meaning of mode and median Be able to evaluate evidence about possible genetic predisposition to develop a disease or disorder Understand that gene mutation produces new D:\106758999.doc Students solve genetic problems involving sex linkage. More practice at genetic crosses. Students research Duchenne muscular dystrophy Students study human pedigrees involving sex linkage, eg Queen Victoria’s family tree and haemophilia CD-rom of Mitosis and Meiosis demystified – see http://www.eti.uva.nl/products/catalo gue/cd_detail.php?id=187 Use pipe cleaner or plasticine models to explain crossing over and independent assortment. Use beads to model random fertilisation and observe new combinations of alleles Students research prader-Willi syndrome Students evaluate data from twin studies to assess the relative effects Use plastiine to show how chromosomes assort independently. Work out problems including mutations of deletion and substitution. Complete exam pack questions about inheritance of mutated alleles. 17/1/11 alleles Be able to explain how deletion and substitution are causes of point mutations Understand that, in meiosis, crossing over and independent assortment lead to new combinations of alleles Be able to explain how random fertilisation leads to new combinations of alleles Understand that genes interact with the environment to produce the phenotype Be able to describe Prader-Willi syndrome and how it produces heritable changes in gene function or cell phenotype without changes in the genotype Be able to evaluate evidence for the relative influences of genetic and environmental factors on phenotype. 3.4.7. Hypothermia and diabetes – Homeostasis Understand that physiological control D:\106758999.doc of genes and the environment, including the limitations of such studies. Write a summary of how negative feedback controls temperature. Discussion of central heating being Power point on temp control. Exam question pack on systems operate in humans to maintain the internal environment within restricted limits. This is homeostasis. Understand the principle of negative feedback and its role in restoring systems to their original levels Understand that hypothermia is a condition in which body temperature falls below thermoregulatory mechanisms fail controlled by a thermostat to explain the principles of homeostasis and negative feedback Negative feedback diagrams Students research advice given to mountaineers, sailors etc to avoid hypothermia if they are outdoors in harsh weather, and work out why this advice is given Be able to explain the normal processes involved in thermoregulation in a mammal, including the role of thermoreceptors in the skin and hypothalamus Be able to describe the role of positive feedback as temperature continues to fall Be able to describe the regulation of blood glucose D:\106758999.doc body temp regulation and glucose regulation. Students analyse data relating to glucose levels, including responses by individuals to the glucose tolerance test Power point on glucose regulation. Use a given scenario to explain how the body responds to cold temperatures. Given scenario to work Scenarios to explain negative and positive feedback. Understand the factors which influence blood glucose concentration Understand the role of hormones in activating enzymes involved in the inter-conversion of glucose and glycogen Understand the role of insulin and glucagon in controlling blood glucose Understand the type 1 and type 2 diabetes and how they may be controlled by insulin, changes of diet and lifestyle Be aware of the health implications of undiagnosed or untreated diabetes Be able to evaluate evidence showing correlations between life-style and the incidence of diabetes 24/1/11 Revision D:\106758999.doc Students test simulated urine samples (cold tea with glucose added) with clinistix and Benedicts reagent. out appropriate responses to low or high blood sugar levels. How Science Works: Students prepare an advisory leaflet about the causes of type 1 and type 2 diabetes, and how they can be controlled. Health risks of untreated or undiagnosed diabetes Use negative feedback diagram to explain Students analyse data relating to the correlation between life-style and the incidence of type 2 diabetes Students discuss government initiatives to reduce the incidence of type 2 diabetes. Mock exam Mock Past Exam exam papers 31/1/11 HBIO4 EXAM Monday 25th January Carry out Coursework instructions under exam conditions. 07/2/11 HBIO4 Re-sit coursework HBIO6 ISA Coursework Carry out Coursework instructions under exam conditions. 14/2/11 3.5.1. Human impacts on evolution Know that evolution involves a change in the allele frequency in a population Understand that individuals in a population of a species show variation Understand that phenotypic variation is due to genetic factors, differences in environmental factors or a combination of both Understand that competition results in differential survival and reproduction Understand that selection acts on D:\106758999.doc Evaluating data from twin studies to ascertain the contribution of genetic and environmental factors on phenotype papers. populations Explain how organisms with a selective advantage are more likely to survive, reproduce and pass on their genes to the next generation Understand that selection may result in changes in the allele and phenotype frequency in a population. Investigate examples of natural selection in action, eg peppered moth, warfarin resistance in rats, copper tolerance in grasses Open University videos such as Rats and Super Rats Be able to describe how reproductive isolation of populations can occur. Be able to explain how new species form by allopatric and sympatric speciation. Relate natural selection and speciation to evolution of humans as studied at AS Understand that human activities have altered and are altering the environment of many organisms, and that this changes the selection acting on populations. This may affect the evolution of populations and species. Adaptations of various species to urban living, eg foxes D:\106758999.doc 21/2/11 28/2/11 Half Term 3.5.2. People Change communities, Ecosystems and the stability of populations Understand that humans have introduced species of plants and animals into this country. This has affected the stability of populations of native species, the communities they are part of and the ecosystems they live in Explain that an ecosystem comprises living organisms and the physical and chemical factors that make up their environment Understand that a population is all the organisms of one species in a habitat Understand that populations of different species form communities. These communities are found in D:\106758999.doc Exam board suggestions: Bioethics Education project website at http://www.beep.ac.uk/content/127.0 .html Students research specific examples, eg grey squirrel, Japanese Knotweed etc and prepare presentations Domestic cats – important predators in the UK Ecological fieldwork in a local site Students list physical and chemical factors that may affect organisms a particular habitat and are based on dynamic feeding relationships. Design a niche – think of a ‘cool’ organism and research all the biotic and abiotic factors that may affect it Understand that, within a habitat, a species occupies a niche governed by adaptation to food availability and/or prevailing abiotic conditions Understand that an ecosystem supports a certain size of population of any one species. This population size may vary as a result of the effect of abiotic factors; interactions between organisms; inter and intra-specific competition; predation. Understand that humans have introduced species of plants and animals into this country. This has affected the stability of populations of native species, the communities they are part of and the ecosystems they live in. When provided with D:\106758999.doc Look at this from the point of view of a sheep farmer. He only has so much land. How many sheep can he keep? What factors will influence this? appropriate information, be able to evaluate evidence and make balanced judgements between meeting human demands and the need to conserve the environment. Explain that domesticated and introduced plants and animals affect natural ecosystems through competition with native species Students investigate numbers of imports of plants and animals and their sources. Eg plants introduced through soil; accidents; food; horticulture; garden centres; cut flowers. Animals introduced through accidents, eg Black Widows; food; pet trade; introduced/released Be able to describe the effects of domestic cats, grey squirrels and Japanese Knotweed Understand that the growth of the urban environment has increased the habitat and niches for foxes, rats, pigeons and other species of wildlife When provided with appropriate information, be D:\106758999.doc Consideration of widespread conifer plantations; removal of hedges; able to evaluate the cost implications of controlling introduced species Understand the meaning of Environmental Impact Assessment Understand the impact on communities and ecosystems of the largescale introduction of genetically modified organisms, as exemplified by soya and maize When provided with appropriate information, be able to evaluate evidence and make balanced judgements between the need to meet the demands for certain crops and the need to conserve the environment D:\106758999.doc drainage of wetlands – how these affect the size of populations due to their effects on the availability of habitats and niches. Competition between grey squirrels and red squirrels. Compare urban and rural fox populations. Describe common features of wildlife in urban environments – why are they survivors? Find out where GM soya and maize products are found. GM Maize with herbicide resistance Bioethics Education project website at http://www.beep.ac.uk/content/127.0 .html Students investigate the nature reserves and habitats in their own area. 07/3/11 3.5.3. Humans’ health can be affected when they change their environment Diet, crops and food allergies Exam board suggestions Understand that there have been changes in our diet Know that vegetable oils are one of the plant products for which there has been a large increase in demand Understand that these changes have been linked to increases in a range of allergies: nut allergy and hay fever When supplied with appropriate information, be able to evaluate evidence judgements about meeting demands for certain crops and the impact on human health and well-being Students investigate the reasons why more oil seed rape has been planted in the UK, and its use for vegetable oils and biofuels. They investigate how this has changed the environment and the effects it has had on other organisms. There have also been effects on humans – for example, people with allergies to the pollen of oil seed rape are at a severe disadvantage. Find out about the use of an Epipen Understand that allergic and prepare an informative leaflet/poster about its use responses produce illness, and that allergens D:\106758999.doc are antigens that produce an abnormal immune response Understand the concept of hypersensitivity, limited to hay fever, food allergies, allergic asthma and hives as examples of reactions involving histamine production Students investigate the common ingredients of over-the-counter remedies for the symptoms of allergies. Understand that the allergen leads to production of IgE antibody by B cells Find out (in outline) how these work to counter anaphylaxis Know that IgE binds to mast cells, which produce histamine when exposed to the allergen, and that histamine leads to symptoms of allergy Understand that anaphylaxis is a sudden, acute reaction to an allergen. It can involve oedema in the airways leading to the lungs, or a large and sudden fall in blood pressure Show knowledge of skin tests for allergies, the use of antihistamine D:\106758999.doc Use Environment Agency website http://www.environmentagency.gov. uk/ and MMU site on air pollution monitoring at http://www.ace.mmu.ac.uk/eae/Air_ Quality/Older/Monitoring.html to treat allergies and adrenaline to treat anaphylaxis When provided with appropriate information, be able to evaluate evidence and make balanced judgements about the claims of links between air pollution and respiratory illnesses, including asthma and bronchitis Understand that pollution of water by human activities can lead to illness Show knowledge of coliform standards Understand that coliform bacteria and faecal streptococci can be indicators of pollution by human sewage Understand that Blue Flag beaches meet a water quality test Understand that Cryptosporidium is a single celled parasite that causes cryptosporidiosis. D:\106758999.doc Teacher carries out presumptive coliform test on different samples of water as a demonstration, eg swimming pool; garden pond; river; paddling pool. A resistant form, the oocyst, is present in the faeces of infected animals and humans, and can infect a new host. Find location of Blue Flag beaches and trends in standards. Examine life cycle diagrams Know that pollution of water can occur from slurries from infected farm animals. Sewage discharged into rivers used for drinking water abstraction can carry oocysts released by infected humans. When provided with appropriate information, be able to evaluate the cost implications of controlling water pollution. 14/3/11 How Science Works: Investigate outbreaks, eg on Anglesey and subsequent legal actions. See www.anglesey.gov.uk/upload/public/ attachments/51 /cryptosporidiumenglish.pdf Evaluate the benefits of treating sewage and methods. 3.5.4. Human activities can damage ecosystems and create new ones Exam board suggestions: Understand that ecosystems are dynamic systems, usually moving from colonisation to climax communities in a Succession of microbeasties – leave a bowl of rainwater in a place where it can be ignored and sample the microbeasties regularly D:\106758999.doc process known as succession. Understand that communities change with time, because of the interaction between species and their environment. At each stage certain species change the environment so that it becomes more suitable for other species. Observe a patch of soil in the area, eg where there is an abandoned building and predict the sequence of colonisation Understand that human activities often produce bare areas of land and water. Know that wasteland is unmanaged land with vegetation in the early stages of succession. Wasteland includes corridor habitat, such as cuttings and embankments associated with railway tracks and Roadsides. Know that brown-field sites are sites which have previously been developed for human use. D:\106758999.doc Predict order of colonisation in flooded quarries or sand pits. These sites can be reclaimed to provide habitats for flora and fauna, as exemplified by species in decline because of urbanisation Research diversity of species in and intensive agriculture brown field sites – in some towns these can be a rich place for wildlife Understand that ecosystems range from very small to the very large. Field visit to a brown field site if there is a suitable site nearby. Understand that increasing area by a factor of ten approximately doubles the number of species present. Understand that larger sites are important in enhancing biodiversity in the urban environment. Understand that corridor habitats are important because they are common in the built environment and allow for the movement of plants and animals between habitats. Be able to describe one example of the habitats on wasteland or a brown D:\106758999.doc field site 21/3/11 Be able to describe techniques used to measure the biotic and abiotic factors in an ecosystem . Understand the meaning of Best Practical Environmental Option (BPEO) as applied to waste management. Understand that the BPEO is the option which provides the most benefit or least damage to the environment as a whole, at an acceptable cost in both the long and the short term. Understand the waste hierarchy: waste should be prevented or reduced at source; waste materials should be reused; waste materials should be recycled and used as a raw material; waste that cannot be reused should be used as a substitute for nonrenewable energy sources; and only waste D:\106758999.doc Exam board suggestions: SLOSS debate – is it better to have a single large or several small nature reserves? http://www.bath.ac.uk/biosci/biodiver sity-lab/consbiol09b.pdf Use maps of local area to plot possible corridors Research rare species that survive in cities Research spread of fireweed or buddleia after World War 2. – or use knotweed again Role play to explore arguments for and against the building of incinerators Compare figures for percentage of waste that gets recycled in different countries Make posters to explain the various disposal options to the public. that cannot be treated in any of the above ways should go to landfill. Design questionnaires to find out how people want to spend money on dealing with waste. Understand that microorganisms decompose organic remains. Local recycling officer is usually willing to come and talk on these issues. Know that anaerobic bacteria produce methane in landfill sites, which can be collected and used as fuel. Observe compost heaps at different stages and what factors affect rate of decomposition Understand the Polluter Pays principle: the polluter pays for the direct and indirect environmental consequences of their actions. When provided with appropriate information, be able to evaluate all the cost implications of pollution. 28/3/11 3.5.5. Plants can reduce the impact of the use of fossil fuels on D:\106758999.doc Bury leaf discs in soil in different size mesh to see how quickly the leaf discs decompose Research explosions from untapped sites Investigate companies that advertise they will take your old item away, and find out what they do with it. Practise cost-benefit analysis studies. Suggested by exam board: Calculate own carbon footprint and compare it with that people from climate change – carbon footprint. Understand that the carbon footprint is a measure of the impact that human activities have on the amount of greenhouse gases produced, measured in terms of kilograms of carbon dioxide produced per year. Be able to describe how their primary contributions are calculated; how their Secondary contributions are calculated; how household contributions can be reduced; and how carbon emissions can be off-set. Understand that the burning of fossil fuels produces greenhouse gases. Understand that the climate of the United Kingdom is getting warmer, which affects the distribution of plants and Animals. D:\106758999.doc other countries eg www.bp.com/extendedsectiongeneri carticle.do?categoryId =9015627&contentId=7029058 Find out how many trees are equivalent to different activities Research the carbon offsetting done by airlines or bands – evaluate whether these are genuine and adequate. Evaluate different carbon offsetting schemes in terms of cost, benefit to wildlife and the environment. Brainstorm carbon storage options, eg seeding the oceans with iron. Investigate ‘invasions’ from mainland Europe and fears of ‘new’ diseases eg blue tongue Investigate changes in the environment, eg the sub Arctic mountain top ecosystem in the Cairngorms is shrinking because of warmer conditions Investigate phenology data on Kew Gardens website http://www.kew.org/wild/phenology/ Research changes we may expect to see in native species and present information as a poster Be able to describe the effects of climate warming on the natural range of species; breeding seasons; and the availability of food for some species at key times. When provided with appropriate information, be able to evaluate evidence of links between climate warming and changes in populations of species in the UK. 04/4/11 ENERGY TRANSFER IN ECOSYSTEMS Understand that photosynthesis is the major route by which energy enters an ecosystem. Know that energy is transferred through the trophic levels in food chains and food webs and is dissipated Be able to consider quantitatively the efficiency of energy D:\106758999.doc Exam board suggestions: Evaluate the ethical issues associated with vegetarianism and meat-eating in terms of land used per person and energy efficiency transfer between trophic levels. PHOTOSYNTHESIS Understand that, in photosynthesis, energy is transferred to produce ATP and reduced NADP in the light independent stage. ATP and reduced NADP are then used during the light independent stage to incorporate carbon dioxide into sugars. Investigate the factors that might increase photosynthesis Understand that ATP synthesis is associated with the electron transfer chains in the membranes of chloroplasts (Details of electron transport and biochemical pathways are not required). Carry out investigations into factors affecting rate of photosynthesis (see practical requirements at end of module). Relate this to predicted changes in climate and how this might affect plants in the UK. Explain how treeplanting is used to off-set carbon emissions and that carbon is sequestered in the biomass of trees. 11/4/11 18/4/11 25/4/11 Rate of photosynthesis investigations using Elodea or Cabomba or algal balls. See SAPS website at http://wwwsaps.plantsci.cam.ac.uk Find out about carbon sources and sinks. Compare different communities in the UK, eg new forest, mature forest, peat land. Easter Easter Bank holiday Monday and Friday D:\106758999.doc Exam board suggestions: Know that biofuels are renewable energy sources: biomass from fast-growing plants, used as fuel for burning; vegetable oils used as diesel substitute; and ethanol from the fermentation of plant material, used as a petrol substitute or additive Understand that the plants used have to be grown on a very large scale to produce significant reductions in the use of fossil fuels. This will have impacts on the environment, and also affect the availability of food for human consumption When provided with appropriate information, be able to evaluate the environmental and social impacts of the use of biofuels. When provided with appropriate information, be able to evaluate the impact of the use of biofuels on national and global carbon D:\106758999.doc Design a crop plant for biofuel use (imaginary) – what features would it have? Present as a poster Discuss the ethics of growing plants as biofuels when some people do not have enough food to eat Investigate the area of land needed to produce any significant amount of biofuel How Science Works: discussion on the ethics of crops grown by people in developing countries – food; fuel; luxuries like tea and coffee; etc and the resulting impact on the country’s economy Discuss whether biofuels really are carbon neutral when you consider harvesting, cultivation, transporting them, etc. 02/5/11 dioxide emissions Bank holiday Monday. Respiration adds carbon dioxide to the atmosphere Understand that ATP provides the immediate source of energy for biological processes, and that all cells and organisms respire 09/5/11 Exam board suggests: Investigate the factors affecting rate of respiration of any suitable organism. (See practical requirements at the end of the module) Annotated diagrams of the different Know that, in stages of respiration respiration glycolysis is anaerobic and takes place in the cytoplasm; the remaining steps take place in the mitochondria; ATP synthesis takes place in the membranes of mitochondria; oxygen is the final electron acceptor; and that carbon dioxide is a waste product of aerobic respiration. 3.5.6. People Exam board suggestions and their microorganisms – the human Ecosystem Understand that ecosystems range in size from the very large to the very small D:\106758999.doc Consider specific ecosystems that vary in size Know that the human body supports populations of bacteria and fungi Understand that microorganisms carry out extracellular digestion of biological molecules; absorb the products of digestion; and use these for their own metabolism. This can recycle chemical elements from human cells. Know that human skin supports a community of many microorganisms including Staphylococci, Micrococci, Corynebacterium and fungi, such as yeast. Explain that a number of skin conditions are caused by bacteria Know that acne vulgaris is caused by Propionibacterium acnes growing in and near sebaceous glands in the skin Understand that D:\106758999.doc Compare the number of cells in a human with the number of cells of other organisms living in or on us Place hand on agar plate and culture microorganisms (subject to carrying out a suitable risk assessment) Consider human skin in terms of an ecosystem – synoptic with start of the unit antiseptics and antibiotics can be used to control the populations of these bacteria When provided with appropriate information, be able to evaluate evidence and make balanced judgements between the claims of makers of different ‘spot creams’ and antibacterial soaps. 16/5/11 HBIO1 Resit Monday 16th May am Exam board suggestions: Be able to analyse and interpret experimental evidence from microbial growth investigations. Find out why newborn babies are given an injection of vitamin K Understand that the human gut supports populations of bacterial species which form a bacterial community Understand that human actions can change this community and adversely affect the functioning of the Gut. Review AS work on probiotic foods Investigate the effect of different antiseptics/face washes on lawns of bacteria When provided with appropriate information, The use of antibacterial agents such as bleach and disinfectants in the home – survey of commonly used D:\106758999.doc Link between use of antibiotics and diarrhoea Research the different species of bacteria used in probiotic foods be able to evaluate evidence and make balanced judgements about ‘probiotic’ foods. Understand that humans have introduced large amounts of antibacterial agents into the environment of bacteria. Be able to explain that bacteria can evolve resistance to antibacterial agents, using MRSA as an example. When provided with appropriate information, be able to evaluate evidence relating to the impact of the widespread use of antibacterial agents. 23/5/11 30/5/11 06/6/11 REVISION HBIO2 Resit Thursday 26th May2011 pm Half Term REVISION 13/6/11 REVISION HBIO4 Re-sit Monday 13th June 2011 pm 20/6/11 HBIO5 EXAM on Wednesday 22nd June 2011 pm D:\106758999.doc active ingredients Find out why farmers use antibiotics How Science Works: investigate the advertising of antibacterials for use in the home, and how they are used. Are they really needed? Should their use be confined to where they are necessary, e.g. in hospitals? Research ‘last resort’ antibiotics and the appearance of resistance to these. Prepare a leaflet for the general public about ‘Don’t ask for antibiotics’ Research alternatives to antibiotics, eg bacteriophage treatments Every Child Matters: D:\106758999.doc Describe how Every Child Matters is integrated into the lesson under the themes: 1. Being Healthy; 2. Staying Safe; 3. Enjoying & Achieving; 4. Making a Positive Contribution; 5. Achieving Economic Wellbeing.