ADVANCED NUTRITION NFS 484F/1484F
2013-2014
Instructor :
Carol Greenwood
FitzGerald Building, room 424; Tel.: 978-4261
Available for Office Hours: Thursdays
Lectures :
0900 - 1100 hr, Thursdays, MSB rm.
Tutorials :
0900 - 1000 hr, Tuesdays
Undergraduate Students MSB rm.
Graduate Students
MSB rm.
2173
2290
2394
Ambekar – F. Luo
M. Luo - Yoo
2173
3290
Bieniek - Kim
LeMay-Nedjelski - Visentin
Course Objectives :
This is an advanced course in nutrition which deals with the analysis of the effect of food and its
constituents on living organisms, with particular emphasis on man. The objectives of the course are
threefold:
1. To integrate nutrition with biochemistry and physiology. The emphasis of the course will be on
metabolism examining its regulation from a cellular to whole body perspective.
2. To develop a basis for appreciation of current research and its application. This will be
accomplished through a combination of lecture material and assigned readings to students.
3. To develop an ability to interpret research data. The focus of the tutorial sessions will be to
develop interpretational skills in students.
Prerequisites: BCH210H1, CSB349H1/PSL350H1/BCH311H1, NFS284H1, PSL302Y1/(PSL300H1, PSL301H1),
(STA220H1, STA221H1/JBS229H1)
Expectations: As this is not intended to be an introductory course, students will be expected to have
a sound knowledge of biochemistry, physiology and introductory statistics.
NFS 484F students will be required to hand in 2 assignments, and write the term test and final
examination.
NFS 1484F students are required by the School of Graduate Studies to complete a piece of work in
addition to that required by NFS 484F students. This will take the form of a third
assignment.
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Evaluation :
Term test (Nov. 7, 2013)
Final exam (set by Arts & Sciences)*
Assignment 1 due Oct. 10, 2013**
Assignment 2 due Nov. 21, 2013
LOCATION OF MIDTERM EXAM
484
30%
50
20
not req’d
1484
30%
50
10
10
Examination Facility Rm 320
* Please note, it is the student’s responsibility to verify the final examination date once posted
and to ensure that travel plans are not made until the examination is completed.
** For students with religious observances on assignment due dates or scheduled exams, please
speak with me in advance to arrange an alternate date.
Both examinations will be an ‘open book’ format. That is, students will be permitted to bring
whatever aids desired (tests, notes, calculators, books, etc.) into the examination room.
{Students are not allowed to bring laptops or other devices with internet access into
examination rooms – UofT policy.} However, students should be cautioned that time
restrictions during the examination do not allow for extensive reading during the
examination. Rather, the aids should be used for ‘refreshment’ purposes only. Students
missing the regularly scheduled tests, and with satisfactory reasoning, will have to write a
supplemental exam. Failure to write a supplemental test will result in a mark of zero for that
component. It is the student’s responsibility to contact the course instructor to schedule a
make-up examination.
Assignments will be posted on the BlackBoard web site one week prior to the due date. Completed
assignments can be handed in either during regular class hours or to the Department’s central
office, FitzGerald Building room 316 up until 1630 hr on the date due; at which time they
will be date stamped. Electronic submission of assignments is not permitted. A late penalty
of 1.5% per day for undergraduate students and 1% per day (i.e. loss of 10% of overall
grade/ day) for graduate students will be assigned (weekends excluded). Failure to submit
an assignment will result in a mark of zero for that assignment.
References :*No specific text is assigned for this course. However, the following textbooks can
serve general reference purposes.
Gropper SS, Smith JL, Advanced Nutrition and Human Metabolism, 6th Ed. 2013.
Harvey RA Ferrier DR . Lippincotts Illustrated Reviews: Biochemistry, North American
Edition. 5th Edition 2011, JB Lippincott, Philadelphia.
Course Notes and Handouts : Lecture notes, tutorial material and previous midterm examinations
can be obtained through Blackboard. Copies of past final exams, in PDF format, are
available through the UofT library and can be accessed electronically. Please download
course notes and tutorial material from Blackboard. This site will continue to be updated
throughout the semester.
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Please Note: We will assign tutorial placements, based on surname. To maintain tutorial sizes
consistent, please do not change your tutorial assignment. All tutorials are run simulataneously on
Tuesday mornings from 9-10 am.
Lecture Schedule
Date
Sept. 12
19
26
Oct. 3
10
17
24
31
Nov. 7
14
21
28
Content
Introduction; overview of approach; Digestion and absorption of protein and CHOs
Effect of diet type on rates of absorption and metabolism
Colon - function, fermentation, absorption of short chain fatty acids
Fat absorption & lipoprotein atherogenicity
Glucose transporters
Integration of CHO metabolic pathways
Role of exercise
Fructose & review
Mid Term Examination
Metabolic adaptation to fasting and starvation
Energy expenditure and substrate utilization
Diet composition and body weight regulation
Tutorial Schedule
Date
Sept. 17
24
Oct. 1
8
15
22
29
Nov. 5
12
19
26
Dec. 3
Content
Introduction
Effect of diet on intestinal enzyme activity
Previous assignment – incretins and blood glucose
Previous assignment - CVD
Effect of dietary fibre on colon cancer susceptibility
Overview of Assignment - HELD IN MSB 2173
PFK activity and fasting; G6Pase activity and fasting
Midterm exam preparation
No tutorial – Fall Break
Overview of midterm examination - HELD IN MSB 2173
Overview of previous final examinations
No tutorial
Tutorial Format
In general, tutorials will be organized as follows:
1. Presentation of relevant background material
2. Discussion of a problem based on research data (found in supplemental reading packet)
The format of the ‘problems’ is similar to the format of exam and assignment questions. These
problems are designed to give students experience in interpretation and application of research data.
The discussion problems should help students develop an appreciation for current research, and gain
experience in interpreting primary literature. The problems assigned vary in complexity, as do
papers in the literature. It is hoped that the tutorials will illustrate how one can learn useful
information from an article that, at first, appears very confusing.
The ‘discussions depend on active participation of students. Form many questions, there are no
right or wrong answers. Instead, the questions are designed for integrating knowledge from
different areas and practice in applying theoretical material from lectures to research situations.
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To gain maximum benefit from tutorials, students should:
1. Read the background reading(s) and discussion problem before tutorial
2. Participate in tutorial discussions
In reading the papers for this and other courses, at the end students should be able to answer the
following:
1. What was the purpose of this study?
2. How did the authors investigate the question? (e.g. what was the study design? methods?)
3. What do the results show?
4. What are the main conclusions?
5. Were the design/methods/conclusions drawn appropriate?
For examination purposes, in general, students will be provided information answering questions 1
and 2 and will be expected to answer questions 3 through 5.