OST 573
Endocrinology
Spring – 2014
Revised 2/28/2014 asl
Table of Contents
Course Description and Goals .................................................................................................. 2 Course Coordinator .................................................................................................................... 2 Course Faculty ............................................................................................................................ 2 Curriculum Assistants ................................................................................................................ 2 Course Web Site ......................................................................................................................... 3 Textbooks and Reference Materials .......................................................................................... 3 i>Clicker Use in Course .............................................................................................................. 3 Course Schedule......................................................................................................................... 4
Specific Procedures for the Histology Laboratory .................................................................. 6
Exams/Assessments .................................................................................................................. 8 Course Grades ............................................................................................................................ 9 Student Evaluation of the Course ............................................................................................. 9 Academic Honesty and Professionalism ................................................................................ 10 Attendance/Excused Absence ................................................................................................. 10 i>Clicker Policy ......................................................................................................................... 11 Remediation Policy ................................................................................................................... 11
Academic Accommodations .................................................................................................... 11 Philosophy of Instruction ....................................................................................................... 112
Notice to Students: Although course syllabi at MSUCOM have a consistent format, vitally important
details differ by course. For this reason, you must read the syllabus thoroughly at the onset of each
course to know what the course will provide and what is expected of you.
1
Section 1 – Course Information
Course Description and Goals
OST 573 is a 3 credit course designed to provide information regarding the anatomy, biochemistry and
physiology of the endocrine systems. The learning objectives included in this course will build on your
understanding of normal function of endocrine system and introduce principles of clinical diagnosis and
management of endocrine abnormalities.
Course Coordinator
Name:
Keith Lookingland, Ph.D. (PHM)
Phone:
517-353-8971
Email:
lookingl@msu.edu
Address: B432 Life Science, East Lansing, MI 48824
Course Faculty
Name:
Peter Gulick, D.O.
Dept:
(OMS)
Phone: 517-353-3211
Email:
gulick@msu.edu
Site:
EL
Frances Kennedy, DVM MS
Name:
(ANTR)
Dept:
Phone: 517-432-0467
kennedyf@msu.edu
Email:
Site:
EL
Ralph Otten, D.O.
Name:
(OMS)
Dept:
Phone: 517-353-3211
otten@msu.edu
Email:
Site:
EL
Carol Wilkins, Ph.D.
Name:
(BMB)
Dept:
Phone: 517-353-4927
mindockc@msu.edu
Email:
Site:
EL
Curriculum Assistants
EL
Name:
Amy Lockwood (LEAD)
Phone: 517-432-7295
Email:
lockwoam@msu.edu
Mary Hughes, D.O.
(OMS)
517-353-3211
hughesm@msu.edu
EL
Sarah McCaskey, MS, RD
(COM)
586-263-6066
mccaske7@msu.edu
MUC
Janice Schwartz, Ph.D.
(PSL)
313-578-9671
schwa317@msu.edu
DMC
DMC
Rose Shubeck
517-884-9667
shubeck@msu.edu
2
Laryssa Kaufman, M.D.
(OMS)
517-353-3211
lkaufman@msu.edu
EL
L. Karl Olson, Ph.D.
(PSL)
517-884-5116
olsonla@msu.edu
EL
Carrie Tatar, Ph.D.
(ANTR)
586-263-6743
tatarcar@msu.edu
MUC
MUC
Katie Schorling
586-226-4788
schorlin@msu.edu
Course Web Site
The URL for the Course web site is http://angel.msu.edu
The course Angel site has these MAIN sections:
 Announcements – Course-related communication to the class will be made here. You
should check for announcements on a daily basis.
 Syllabus - Information about textbooks, exam dates, grading system, rules and
regulations, etc. as well as information on the instructional team.
 Course Content – Lecture recordings, tutorials (TT), self-study modules (SSM), and all
other scientific material will be deposited here.
 Discussion Board – List of “asked" questions. It is highly recommended that you check
the discussion board prior to sending a question to faculty as it is very likely that you are
not the only student with a given question and it may already have been answered.
Textbooks and Reference Materials
Required
 OST 573 Course Pack
 Rhoades RA and DR Bell,
Medical Physiology: Principles for Clinical
Medicine 4th ed.(2013) Lippincott Williams &
Wilkins [ISBN# 9781609134273]
 MH Ross and W Pawlina,
Histology: A Text and Atlas 6th ed. (2011)
Lippincott Williams & Wilkins [ISBN#
9780781772006]
 Kumar, V et al.,
Robbins and Cotran Pathologic Basis of
Disease 8th ed. (2010) Saunders Elsevier [ISBN:
9781416031215]
 Sadler, TW,
Langman’s Medical Embryology 12th ed.
(2012) Lippincott Williams and Wilkins
[ISBN: 9781451113426]
 Ferrier D.,
Lippincott’s Illustrated Reviews:
Biochemistry 6th ed. (2013) Wolters Kluwer
Health/Lippincott Williams and Wilkins
[ISBN: 9781451175622]
Recommended
 Bruton, L.E.,
Goodman and Gilman’s : Pharmacological
Basis of Therapeutics, 12th ed. 2011
McGraw-Hill
[ISBN# 9780071624428]
Available online: www.accessmedicine.com or
www.statref.com
 Electonic Medical Books listed by subject can
be found at:
http://libguides.lib.msu.edu/medicalebooks
i>Clicker Use in Course
For the Histology Labs in this course, you must have a functional i>Clicker that is registered in
accordance with MSUCOM instructions in order to submit your answers to the quizzes that will
be given at the beginning of each histology laboratory.
3
OST 573 Endocrinology - Course Schedule
Date
3/10/14
3/10/14
3/11/14
Time
7:45am
9:00am
8 am
Origin
ONLINE
DMC
EL Conrad
3/12/14
10am
EL Conrad
3/12/14
3/13/14
11am
8am
EL Conrad
EL Conrad
3/13/14
9am
EL Conrad
Fri
Fri
3/14/14
3/14/14
10am
11am
EL Conrad
EL Conrad
Title
Introduction
1. Endocrine Physiology Overview
2. Cholesterol and bile salt synthesis, Lipid
soluble vitamins
3. Lipid digestion / absorption / transport
Lipoproteins 1
4. Lipoproteins 2
5. Integration of metabolism: Hormones Insulin
and Glucagon
6. Integration of metabolism: Epinephrine,
Cortisol and Growth Hormone
7. Biochemistry of Fed / Starved States
8. Starved State vs. Diabetes
Mon
Mon
Tues
3/17/14
3/17/14
3/18/14
3/18/14
8am
9am
8am
9am
EL Conrad
EL Conrad
EL Conrad
EL Conrad
9. Physiology of the Pancreas
10. Physiology of Diabetes
11. Beta Cell Physiology
12. Pathophysiology of DM Complications
3/19/14
3/19/14
3/19/14
8am
9am
1-7:30p
Thurs
Thurs
3/20/14
3/20/14
10am
11am
EL Conrad
EL Conrad
EL
DMC
MUC
EL Conrad
EL Conrad
13. Insulin and Glycemic Control Agents
14. Diabetes Diagnosis & Management 1
Endocrine Histology Lab (2hr, 3 sections)
1-3pm; 3:15-5:15pm; 5:30-7:30pm
i>clicker quiz
15. Diabetes Diagnosis & Management 2
16. PSL of Mineralocorticoids, Catecholamines
Mon
Tues
Tues
Tues
Tues
Wed
3/24/14
3/25/14
3/25/14
3/25/14
3/25/14
3/26/14
3/26/14
MUC
EL Conrad
EL Conrad
EL Conrad
EL Conrad
EL Conrad
EL, DMC,
MUC
17. Diet and Diabetes
18. Diabetic Comas (DKA, lactic acidosis)
19. Diabetic Comas (HHS, hypoglycemia)
20. PSL of Glucocorticoids, Adrenal Androgens
21. Pharmacology of Adrenal Steroids
22. Clinical Adrenal Diseases
Quiz #1 (prior to small group session)
McCaskey
Otten
Otten
Kaufman
Lookingland
Kaufman
EL, DMC,
MUC
Small Group #1 – (EVOLVE Clinic –
Endocrine Focus) (2-hr, 2 sections)
IM Faculty
3/27/14
3/27/14
10am
8am
9am
10am
11am
11am
1:00-1:15p
or
3:00-3:15p
1:15-3:00p
or
3:15-5:00p
11am
5:15-6:00pm
EL Conrad
23. Thyroid Physiology
Histology Help Session
(LOCAL-NO MEDIASITE)
3/28/14
3/28/14
3/28/14
9am
10am
11am
Kaufman
Kennedy
Schwartz
Tatar
Lookingland
Otten
Otten
Mon
Mon
Tues
Wed
Wed
Thurs
Thurs
Tues
Wed
Wed
Wed
Wed
3/26/14
Wed
Thurs
Thurs
Fri
Fri
Fri
EL E105
DMC G031
MUC UC4-211
EL Conrad
EL Conrad
EL Conrad
24. Thyroid Hormones & Antithyroid Agents
25. Clinical Thyroid 1
26. Clinical Thyroid 2
4
Presenter
Lookingland
Schwartz
Wilkins
Wilkins
Wilkins
Wilkins
Wilkins
Wilkins
Wilkins
Kaufman
Kaufman
Olson
Kaufman
Olson
Lookingland
Kaufman
Kennedy
Schwartz
Tatar
Kaufman
Kaufman
Date
Mon
Tues
Tues
Tues
Tues
Wed
Wed
Fri
Mon
Mon
Tues
Tues
Tues
Tues
Wed
Wed
Wed
EL, DMC,
MUC
EL Conrad
EL Conrad
EL Conrad
DMC
Unit Exam 8
(Lectures 1-22)
27. Clinical Thyroid 3
28. Endocrine Control of Growth & Develop.
29. PSL of GH, Prolactin, Pituitary Adenomas
30. Physiology of Reproduction –
Fundamentals
31. Physiology of Male Reproductive 1
32. Physiology of Male Reproductive 2
Male Reproductive Histology Lab
(2hr, 3 Sections) 1-3pm; 3:15-5:15pm or 5:307:30pm i>clicker quiz
33. Physiology of Calcium Regulation
34. Hypercalcemia, Hypocalcemia;
Osteoporosis
7:30-9:50a
4/1/14
4/1/14
4/1/14
4/1/14
8am
9am
10am
11am
4/2/14
4/2/14
4/2/14
10am
11am
1:00-7:30p
4/4/14
4/4/14
10am
11am
DMC
DMC
EL
DMC
MUC
EL Conrad
EL Conrad
4/7/14
4/7/14
4/8/14
4/8/14
4/8/14
9am
10am
8am
9am
10am
DMC
DMC
DMC
DMC
EL Conrad
4/8/14
11am
EL Conrad
4/9/14
4/9/14
4/9/14
4/9/14
9am
10am
11am
1:00-7:30p
4/10/14
4/11/14
1:00-1:15p
or
3:00-3:15p
1:15-3:00p
or
3:15-5:00p
12-12:50p
ONLINE
ONLINE
EL Conrad
EL
DMC
MUC
EL, DMC,
MUC
4/14/14
7:50-9:50a
Wed
Thurs
4/10/14
Thurs
Fri
Mon
Title
3/31/14
Wed
Fri
Origin
Otten
Lookingland
Kaufman
Schwartz
Schwartz
Schwartz
Kennedy
Schwartz
Tatar
Kaufman
Kaufman
35. Reproductive and GU Embryology
36. Physiology of Female Reproduction 1
37. Physiology of Female Reproduction 2
38. Physiology of Female Reproduction 3
39. Clinical Reproductive & Embryology
Cases1
40. Clinical Reproductive & Embryology
Cases2
41. Endocrine Manifestations of HIV Infection
42. Endocrine Emergencies
43. Pharmacological Control of Fertility
Female Reproductive Histology Lab
(2hr, 3 Sections) 1-3pm; 3:15-5:15pm or 5:307:30pm i>clicker quiz
Quiz #2
Schwartz
Schwartz
Schwartz
Schwartz
Kaufman
EL, DMC,
MUC
Small Group #2 – Endocrine Emergencies
Cases (2-hr, 2 sections)
IM Faculty
EL Conrad
DMC G031
MUC UC4-211
Histology Help Session
(LOCAL-NO MEDIASITE)
Kennedy
Schwartz
Tatar
EL, DMC,
MUC
Unit Exam 10
(Lectures 23-43; Comprehensive)
Totals: 43 h lectures; 6 h lab*; 4 h small group cases* lab sessions and small group case discussions include quiz questions
5
Presenter
Kaufman
Gulick
Hughes
Lookingland
Kennedy
Schwartz
Tatar
Specific Procedures for the Histology Laboratory
Access
Locations of histology teaching labs
EL – Room E200 Fee Hall
DMC – Room G031
MUC – Room 211 of the UC-4 Building
At all campus sites, the lab is computer-based; it uses virtual slides (digitized microscope slides)
as well as images from other designated web sites. Students will team up (in groups of 2-3) to
share the laboratory workstations. At each lab session, you will need your lab manual
(contained within the coursepack), your required histology text (Ross and Pawlina) and your
i>Clicker.
Assigned lab times
For each lab topic in this course, you have been assigned to a specific 2-hour histology lab
session (lab section assignments will be posted on the OST573 Endocrinology Angel website).
Space and instructional support are limited in the histology lab, so it is essential that you attend
only the 2-hour lab section to which you have been assigned. Also, answers that you submit
during lab i>Clicker quizzes will earn course credit only if you are attending the lab session to
which you are assigned.
Pre-lab preparation
To make your time in histology lab productive, it is essential that you prepare beforehand. For
each lab session your Study Guide (coursepack) includes detailed, step-by-step instructions,
objectives, and study questions. To prepare for a lab session, carefully read the “Introduction”
to the session in your Study Guide, and work through the instructions that are entitled “Be sure
to review and understand the following.” You should also skim through the detailed
directions for the lab session (lab objectives) in order to get an idea of what you will be expected
to accomplish during the lab session.
Resources to bring to each laboratory session
 i>clicker – In order to receive Individual Readiness Quiz (IRQ) credit, you must
personally attend the lab session to which you are assigned, and you must submit
answers using your personal i>clicker, which you have web-registered in
accordance with directions provided by MSUCOM. IRQ answers submitted in
another way (e.g. written on paper) will not be accepted. Having your personal i>clicker
registered in your name and in good working order (with fresh batteries) is your
responsibility!
 Study Guide (coursepack) – This is an essential guide to the structural features you are
looking for during lab and to their significance.
 Histology textbook – Both the Study Guide (coursepack) and online lab material will
refer frequently to pertinent figures in the required histology textbook (Ross and
Pawlina), so bring your histology textbook with you to lab!
6
Histology Lab Individual Readiness Quizzes (IRQs)
As further reinforcement for advanced lab preparation, we will begin each histology lab session
with a brief Individual Readiness Quiz (IRQ), to be administered via the i>Clicker system (the
i>Clicker system is described under the “College and Course Policies” section of this syllabus).
Course credit will be awarded for answering IRQ questions correctly (see Exams/Assessments
sections of this syllabus). The IRQ questions should not be difficult for students who have
completed the pre-lab preparation, as described above. No make-ups are offered for missed
IRQs.
Making the most of your time in histology lab
Being well prepared for each histology lab session (as directed above) and staying for the full
lab time will allow you to take full advantage of the opportunity that each lab provides to work
collaboratively with your classmates. Lab sessions provide students with excellent opportunities
for face-to-face conversations with faculty about lab material, other course content, or ancillary
matters of interest. Furthermore, participating in the interactive review of questions (carried out
in the last half hour of each lab session) will provide valuable preparation for the integrative
questions on course exams.
Protecting the laboratory work stations
 Do not consume food or drink while seated at a computer station.
 Do not touch the computer monitor screens with anything other than the pointers that are
supplied. No finger prints! No ball-point pens!
 During histology lab sessions, do not use the lab computers for activities unrelated to lab
work (i.e., no personal e-mail, downloads, or web surfing).”
7
Exams/Assessments
There will be a total of 2 exams given in OST573 Endocrinology this year. Your accumulated
score on these exams will determine your grade in the course. The examination schedule is as
follows:
Projected Points
Material to be Covered
Endocrine Histology Lab Quiz
Wed., 3/19/14
1-3pm; 3:15-5:15pm; or 5:30-7:30pm
2
i>clicker quiz
Quiz
Wed., 3/26/14
1:00 – 1:15 pm or 3:00-3:15pm
(prior to small group session)
8
Lectures 1-22
Unit Examination #8
Mon. 3/31/14
7:30 am – 9:50 am
72
Lectures 1-22 (3/10/14 through
3/26/14 and Endocrine Histology
lab and Evolve Clinic case
Male Reproductive Histology Lab
Quiz
Wed., 4/2/14
1-3pm; 3:15-5:15pm; or 5:30-7:30pm
2
i>clicker quiz
Female Reproductive Histology Lab
Quiz
Wed., 4/9/14
1-3pm; 3:15-5:15pm; or 5:30-7:30pm
2
i>clicker quiz
Quiz
Thurs., 4/10/14
1:00 – 1:15 pm or 3:00-3:15pm
(prior to small group session)
Unit Examination #10
Mon., 4/14/14
7:50 am – 9:50 am
8
Lectures 23-43
75
Lectures 23-43 (3/27/14 through
4/11/14) and Male and Female
Histology labs, and Endocrine
Emergencies Small Groups, and
all other course materials/activities
TOTAL POINTS POSSIBLE: 169 POINTS
Each Histology Laboratory session will begin with a brief Individual Readiness Quiz
(IRQ), which will be administered via the i>Clicker system. No make-ups are offered
for lab quizzes (IRQs).
8
Course Grades
 P-Pass—means that credit is granted and that the student achieved a level of
performance judged to be satisfactory by the instructor. To obtain a “P” grade for this
course, a student must obtain 70% or greater or a total of at least 118 points.
 N-No Grade—means that no credit is granted and that the student did not achieve a
level of performance judged to be satisfactory by the instructor. A student who
accumulates less than 118 points or an accumulated score below 70% will receive a “N”
grade.

Remediation - Since all of the courses in the MSUCOM curriculum are required, any
student receiving an “N” grade must remediate the course. If eligible, a written exam will
be given and a score of 70% or higher of the total points possible will be needed to
receive a “P” grade for remediation. Please refer to the remediation policy information
provided in Section 2 of this syllabus for information on College requirements and
eligibility determination.
Student Evaluation of the Course
We want your feedback on how to make this course better for yourself and also for the students
who come after you.
 Informal Feedback: Feel free to approach the Course Coordinator, Keith Lookingland, or
any of the other course faculty with your reactions and suggestions. Or write out your
comments and email them to the Course Coordinator or Faculty
 Formal Evaluation: In addition to the above, we ask every student in the class to complete
formal on-line course evaluation upon conclusion of the course.
Student Course Evaluations are REQUIRED. Student feedback provides Course
Coordinators with valuable information regarding their performance, the performance of
their colleagues, and the quality of the course. The information gained from these
evaluations is used to continuously improve future offerings of this course. Students can
access the evaluation system at: http://kobiljak.msu.edu/Evaluation/UnitI_II.html and it will
be available from 4/14-4/19/13. Your assistance in this important process is greatly
appreciated.
9
Section 2 – Policies
Academic Honesty and Professionalism
http://www.com.msu.edu/ss/professionalism.html
Each individual student is responsible for their behavior and is expected to maintain standards
of academic honesty and professionalism. If any instance of academic dishonesty (cheating,
plagiarism, etc.) is discovered by an instructor, it is his or her responsibility to take appropriate
action. Such action may include giving a failing grade to the student in the course and/or
referring the student for judicial review and possible disciplinary action, which may include
disciplinary suspension or dismissal from the College.
Attendance/Excused Absence
In accordance with the MSU All-University Policy on Attendance, MSUCOM does not have a
regulation requiring class attendance. However, the College understands and supports the
need and the right of the faculty to expect student attendance and participation in many
curricular components with consequences if the student is not attending. In the spirit of
professional behavior, MSUCOM students are expected to attend required class sessions (e.g.,
lectures, laboratories) and take all examinations during their originally scheduled times. If this is
not possible, the student must obtain an excused absence. To obtain an excused absence, you
need to make the following contact, as appropriate, prior to the scheduled administration of the
examination(s).
 Personal Emergencies:
(e.g., death in family, serious illness (acute), hospitalization, automobile difficulties).
EL Dr. Falls, Associate Dean for Student Services
(517) 353-8799
DMC Dr. Willyerd, Associate Dean
(313) 578-9600
MUC Dr. Hortos, Associate Dean
(586) 263-6731
 Where there is advance notice of absence:
To obtain an excused absence, you need to make one of the following contacts as
appropriate:
EL Dr. Falls, Associate Dean for Student Services
(517) 353-8799
DMC Dr. Willyerd, Associate Dean
(313) 578-9600
MUC Dr. Hortos, Associate Dean
(586) 263-6731
For advance notice absences, a student must submit his/her excused absence request at least
one week in advance of the scheduled mandatory class session(s) or examination(s). Wedding,
family celebrations, vacations, conferences, etc are not considered acceptable excuses. If an
examination or other required experience is missed due to medical reasons, an attending
physician’s written confirmation will be required in order for the absence to be excused.
10
Changes in lab assignment:
Any change in your lab time assignment must be based on compelling need and negotiated in
advance with MSUCOM Academic Programs. If you seek such a permanent lab reassignment,
contact the Curriculum Assistant for your campus (as listed earlier in this syllabus).
Individual Readiness Quizzes (IRQs) in Histology Lab – Expected conduct
The expectations regarding professional behavior and academic honesty that apply to
examinations are to be applied during IRQs as well. An IRQ will be administered at the
beginning of each lab session. It is your responsibility to be on time. You may be assigned to a
specific seat for an IRQ, and you may be asked to change seats during an IRQ. All IRQs are
“closed book.” You must not consult notes, books, electronic devices, or other reference
material during an IRQ. During an IRQ, you must not communicate answers to IRQ questions
to another student or attempt to copy answers from another student. Moreover, you are not to
reveal the content of an IRQ to a student who is assigned to a subsequent lab section and
therefore has not yet taken the IRQ. Answering quiz questions on behalf of another
student is considered to be an act of academic dishonesty and may result in dismissal
from MSUCOM. “
i>Clicker Policy
http://www.com.msu.edu/ss/iClicker.html
You are expected to have your i>Clicker registered prior to the beginning of this class. You are
responsible for bringing your i>Clicker to every class with you. Class will proceed as planned,
even if you have forgotten to bring your i>Clicker with you. Paper completion of i>Clicker
activities will not be accepted as a substitute for the i>Clicker response. Please make sure that
your i>Clicker is always in working order.
As a matter of professionalism, please note that under no circumstances should you loan your
i>Clicker to another student. Nor should you ever be in the possession of an i>Clicker other than
your own. Answering questions or checking in for attendance on behalf of another
student by using their i>Clicker is considered to be an act of dishonesty and may result
in dismissal from the college.
Remediation for OST573 Endocrinology
Remediation will be determined on an individual basis and may include re-enrollment in the
course. Not all students will be eligible for remediation. A final decision regarding the
remediation format is at the discretion of the course coordinator.
 The remediation exam is comprehensive for the course. Passing is 70%.
Remediation Policy
http://www.com.msu.edu/Students/Policies_and_Programs/Policies_Programs.htm
College Policies
Remediation of an “N” grade will be governed by the MSUCOM Policy for Retention,
Promotion and Graduation 5.1.4 Remediation of “N” Grades, and by the remediation
section of each course syllabus. It is the responsibility of each student in the
Michigan State University College of Osteopathic Medicine to verify his/her eligibility,
with the Office of Student Services, prior to the administration of the remediation
examination/experience.
11
Academic Accommodations
Michigan State University is committed to providing equal opportunity for participation in all
programs, services and activities. Requests for accommodations by persons with disabilities
may be made by contacting the Resource Center for Persons with Disabilities at 517-884-RCPD
or on the web at rcpd.msu.edu. Once your eligibility for an accommodation has been
determined, you may be issued a Verified Individualized Services and Accommodation (VISA)
form. Please present the VISA to Cheryl Luick, luick@msu.edu, A-331 East Fee Hall at the start
of the term and/or two weeks prior to the assessment event (test, project, labs, etc.). Requests
received after this date will be honored whenever possible.
It is the responsibility of the Student with Accommodations to contact the Course Coordinator
and the Curriculum Assistant in your location, two weeks prior to the start of the term, or two
weeks prior to the scheduled assessment event. Requests received after this date will be
honored whenever possible.
It is the responsibility of the student to submit or have submitted an updated version of
their accommodations to Cheryl Luick each semester that a student plans to use their
accommodations.
Philosophy of Instruction
In this course, the successful achievement of learning objectives will require knowledge
and skills acquired in other portions of the overall MSUCOM educational program.
Students will be expected to apply concepts and vocabulary learned in other courses to
problem-solving for exams/assessments in this course
12