Title: “Pressors, preload reducers, and pumping agents: Hemodynamic drip titration made easy” Speaker: Alexander Johnson Summary of Key Points: I. Introduction II. Endpoints: Optimizing the Macrocirculation and Microcirculation a. Traditional Methods of Hemodynamic Monitoring i. Urine Output, Mental Status, Heart Rate Can Mislead Clinicians ii. Inaccuracies of Cardiac Filling Pressures (CVP, PAWP, etc.) iii. Controversy Surrounding Pulmonary Artery Catheter iv. Blood Pressure 1. Blood pressure Does Not Equal Blood Flow. 2. Blood Flow Can Decrease Blood Pressure Decreases b. Optimizing the Macrocirculation i. Stroke Volume c. Optimizing the Microcirculation i. Blood Lactate, ScvO2 III. Components of Hemodynamic Monitoring a. Preload b. Afterload c. Contractility d. Value of Trending, Early Signs IV. Vasoactive Agents a. Pressors (norepinephrine, dopamine) b. Preload Reducers (nitroglycerin, furosemide) c. Pumping Agents (dobutamine, milrinone) d. Afterload reducers (nitroprusside) V. Case Studies a. Fluid Resuscitation b. Fluid Overload c. Sepsis d. Hypertension Speaker Email: apjccrn@hotmail.com References: Connors AF Jr, et al. Chest. 1990 Nov;98(5):1200-6. Iregui MG, et al. Am J Crit Care. 2003 Jul;12(4):336-42. Bakker J, Jansen T. Intensive Care Medicine. 2007; 33:1863-1865. Marik P,et al. Chest. 2008; 134(1):172-8. Dellinger P, et al.Critical Care Medicine. 2008;36:296-327. Agency for Healthcare Research and Quality. Accessed 2-14-2010 at http://www.cms.hhs.gov/determinationprocess/downloads/id45TA.pdf Cochrane Collaboration website. Accessed 3-15-2010 at http://www2.cochrane.org/reviews/en/ab003408.html Balk E, et al. AHRQ Technoloy Assessment Report. 2008, Accessed at http://www1.cms.gov/determinationprocess/downloads/id55TA.pdf on November 11, 2010. Mowatt G, et al. Health Technology Assessment. 2009;13(7):1-134. Center for Medicare and Medicaid Services. Accessed 11-12-2010 at https://www.cms.gov/transmittals/downloads/R63NCD.pdf Bilkovski R, et al. Curr Opin Crit Care. 2004;10:529-538. Pope J, et al. Ann Emerg Med. 2010;55(1);40-46.e1