2012
Taiwan-Japan Joint Symposium on
Medical Device Innovation
台日創新醫療器材國際研討會
Date
3/10
Sat.
Venue National Cheng Kung University
International Conference Hall
Lecture room 3
Hosted By Medical Device Innovation Center,
National Cheng Kung University ,
Tainan Taiwan
Department of Biomedical Engineering,
Tohoku University, Japan
National Cheng Kung University
Contents
Speakers’ curriculum vitae and abstract
Su, Fong-Chin, NCKU
Medical Device Innovation at NCKU
1
Yamaguchi, Takami, Tohoku University
Education and Studies in the Graduate School of Biomedical Engineering of Tohoku
University
3
Wang, Shyh-Hau, NCKU
High Frequency Ultrasound Technologies for Characterizing Biological Tissues and
Materials
6
Yoshifumi, Saijo, Tohoku University
Advanced Biomedical Ultrasound Technologies to Explore Cardiovascular Dynamics
and Biomechanics
9
Haga, Yoichi, Tohoku University
Medical Devices for Minimally Invasive Diagnosis and Therapy Using Micro/nano
Fabrication Technology
19
Chen, Yih-Fan, NCKU
Nanomanipulation Using Near Field Photonics
20
Ishikawa, Takuji, Tohoku University
Transport Phenomena in Suspensions of Biological Cells
25
Chuang, Han-Sheng, NCKU
"Worm in a drop"
27
Tanaka, Tetsu, Tohoku University
Development of implantable medical micro/nano devices based on semiconductor
technology
28
Chen, Jia-Jin Jason, NCKU
Applications of Implantable Biomicrosystems
30
Curriculum Vitae
Fong-Chin Su, PhD
Department of Biomedical Engineering
National Cheng Kung University
Tainan, Taiwan 701
Email: fcsu@mail.ncku.edu.tw
Fong-Chin Su is Distinguished Professor, National Cheng Kung University (NCKU)
and President of Taiwanese Society of Biomedical Engineering. He is actively
involved in biomechanics-related activities. Dr. Su is a founding councilor of
Asian-Pacific Association for Biomechanics. In addition, he was the congress chair of
i) the 13th International Conference on Mechanics in Medicine and Biology, 2003 in
Taiwan, ii) XIth International Symposium on Computer Simulation in Biomechanics,
Tainan, Taiwan, June 28-30, 2007, iii) 6th Triennial International Hand and Wrist
Biomechanics Symposium, Tainan, Taiwan, June 29-30, 2007, iv) 7th International
Symposium on Nano-Biomedical Engineering, XIth International Symposium on
Computer Simulation in Biomechanics, Tainan, Taiwan, October 16-17, 2008, v) 1st
Taiwan-Japan Symposium on Innovative Health Technology-Medical and Assistive
Devices, Tainan, Taiwan, Nov 9-10, 2009, vi) IVth Symposium & Workshop on
Virtual Interactive Musculoskeletal System, Tainan, Taiwan, October 28-29, 2010,
and vii) 5th WACBE World Congress on Bioengineering, Tainan, Taiwan, Aug 18-21,
2011. He received his Ph.D. degree from Department of Mechanical Engineering,
University of Rochester, USA in 1989 with major in solid mechanics and
biomechanics. His research focuses on biomechanics of human movement, hand
biomechanics and upper extremity biomechanics. He joined the NCKU faculty of
bioengineering in 1989. Meanwhile, he visited Orthopedic Biomechanics Laboratory
in the Mayo Clinic, MN, USA as a visiting scientist between 1993-94, a visiting
professor at the Muscle Physiology Laboratory, Department of Bioengineering,
University of California in the summer of 1999, and a visiting professor, Department
of Biomedical Engineering, University of Rochester, 2004-05. He has published 176
journal papers, 7 book chapters, 493 conference papers and 81 other publications and
edited several conference proceedings and a book (Google citations: 1596, h-index:
23). In addition, he is Deputy Editor-in-Chief of the Journal of Medical and
Biological Engineering, is an editorial board member for Clinical Biomechanics, the
Journal of Applied Bionics and Biomechanics, The Open Biomedical Engineering
Journal, and the Journal of Mechanics in Medicine and Biology, and serves as
Scientific Reviewer for several international biomechanics journals. With regard to
professional activities, he is Past-President of Taiwanese Society of Biomechanics, an
Executive Councilor of the Taiwan Rehabilitation Engineering & Assitive Technology
Society and the Taiwan Industrial Technology Association and Secretary Elect of
World Association for Chinese Biomedical Engineers. He was also a scientific peer
review coordinator for Biomedical Engineering grant application, National Science
Council, Taiwan.
1
Medical Device Innovation at NCKUCenter of Excellence, Taiwan
Lecture Time: 10:30-11:00
Fong‐Chin Su
Director of Medical Device Innovation Center, Distinguished Professor,
Department of Biomedical Engineering, and President of Taiwanese Society of
Biomedical Engineering
Abstract
To promote NCKU to be one of Asia’s major comprehensive research universities in
the 21st century to face humanity’s global challenges, NCKU has been designated by
the Ministry of Education as one of the two major comprehensive research
universities to be “excellence” in two five‐year grants since 2006. Medical Device
Innovation Center (MDIC) has been selected as one of national center of excellence
from 2011. MDIC aims to foster creativity and innovation in medical device
technology to meet the promotion policy of the six emerging industries project,
Taiwan Government. By integrating fundamental research, applied translational
research, education and training within National Cheng Kung University (NCKU) and
related institutes in south Taiwan, and industrial/public engagement, this Center will
promote interdisciplinary research and development of class II‐II medical devices.
The major mission of this Center is to bridge the gap between the Southern Taiwan
Biomedical Device Industry Cluster Development Project and medical centers with
focus on medical innovation, design and prototypes, pre‐clinical and clinical trials,
and education initiatives. It will motivate design/innovation entrepreneurship
education initiatives in biomedical engineering to become a Center of Excellence in
medical devices in the world. The research and development in medical devices will
be introduced.
2
Curriculum Vitae
Name: Takami YAMAGUCHI
Date of Birth: 19th May, 1948
Place of Birth: Aizuwakamatsu, Fukushima, Japan
Nationality: Japanese
Marital Status: Married - one child
Schooling: Aizu High School, Aizuwakamatsu, Fukushima, Japan
Degrees: Bachelor of Medicine (Tohoku University) 1972
Women's
Medical
College)
M.D. (Tokyo
(Tokyo
Women's
Medical
College) 1980
Ph.D.(University of Tokyo)
1981
Present Appointment:
Professor
Department of Biomedical Engineering
Graduate School of Biomedical Engineering
Tohoku University, since 2009 Previous:
Professor
Department of Bioengineering and Robotics
Graduate School of Engineering
Tohoku University, 2003 - 2008
Professor
Department of Mechatronics and Precision Engineering
Graduate School of Engineering
Tohoku University, 2001-2003
Professor
Department of Mechanical and Systems Engineering
Graduate School of Engineering,
Nagoya Institute of Technology, 1997-2001
Professor
Dept. Bio-Medical Engineering,
School of High-Technology for Human Welfare,
Tokai University, Numazu, Shizuoka, Japan, 1991-1997
Chief Scientist,
Department of Vascular Physiology,
Research Institute of the National Cardiovascular Center, Osaka, 1984-1991
Research Fellow (Wellcome Research Fellow),
Physiological Flow Studies Unit,
Imperial College of Science and Technology, London, 1981-1983
Research Associate, Department of Surgical Science,
The Heart Institute Japan, Tokyo Women's Medical College, Tokyo,
1977-1984
3
Research Associate, Department of Cardiovascular Surgery,
The 2nd Hospital , Tokyo Women's Medical College, Tokyo, 1976-1977
House Surgeon, Department of General Surgery,
Takeda General Hospital, Aizuwakamatsu, Fukushima, Japan
Learned Societies:
Japanese Society of Mechanical Engineers
American Society of Mechanical Engineers
Japan Society of Biorheology
International Society of Biorheology
European Society of Mechanics
Japan Society of Fluid Mechanics
Japanese Society of Biological and Medical Engineering
Social Acitivities:
Founding Chair, Asian Pacific Association for Biomechanics
Past Chair, Bioengineering Division, Japan Society of Mechanical Engineers
Fellow, Japan Society of Mechanical Engineers
Past Member, World Council of Biomechanics
Member, Science Council of Japan
Prizes:
Accomplishment Prize from the Japan Society of Mechanical Engineers, 1998
Education Award from the Japan Society of Mechanical Engineers, 2009
The Commendation for Science and Technology by the Minister of Education,
Culture, Sports, Science and Technology, The Prize for Science and
Technology, 2010
Merit Prize from the Japan Society of Mechanical Engineers. 2011
Current Academic Interests:
Application of computational biomechanics to clinical cardiovascular medicine
Particle based simulation of the blood flow
4
Education and Studies in the Graduate School of
Biomedical Engineering of Tohoku University
Lecture Time: 11:00-11:30
Takami Yamaguchi MD PhD
Abstract
Based on the continuous education and studies on the biomedical engineering dated
back to 1930’s, we inaugurated the Graduate School of Biomedical Engineering at
Tohoku University in 2009. It is the first and only purpose-built independent graduate
school for biomedical engineering in Japan. We at Tohoku University also were
awarded consecutive 21st Century COE and GCOE programmes in biomedical
engineering from the Ministry of Education, Culture, Sports, Science, and Technology
of Japan, and ours was the only programme in this field to be awarded both. When we
started the GCOE programme in 2007, we declared that nano-scale biomedical
engineering is undoubtedly the most rapidly growing field of engineering and will
become the most important one because of the incredibly rapid developments in
science and technology in this area, especially the biological sciences. With the
accelerating growth of biological engineering studies, we believe that we have played
a pivotal role with our cross-disciplinary studies involving engineering and biology.
Developments in the nano-scale biomedical engineering promoted by the 21COE and
GCOE programmes will be discussed by four representative and promising young
professors in the forum.
Both Tohoku University and the city of Sendai were gravely damaged by the East
Japan Earthquake of 11 March 2011. The engineering school campus, which is
located atop hills west of the city, was partially destroyed. Nevertheless, we are
delighted to announce that activities returned to almost normal by the end of the 2011
academic year, and we ultimately produced more excellent graduates that year. When
we were affected by the disaster, many friends and colleagues worldwide particularly
in Taiwan expressed their sympathy and took action to help us. We are sincerely
grateful for their support and are honoured to have such good friends. It is therefore
our delight to visit you and present results of our nano-biomedical engineering
studies.
5
Curriculum Vitae
Shyh-Hau Wang
Department of Compute Science and Information Engineering (CSIE)
Institute of Medical Informatics (IMI)
National cheng Kung University (NCKU), Tainan, Taiwan
Phone: +886-6-2757575 ext. 62519
E-mail: shyhhau@mail.ncku.edu.tw
Education
1997
Ph.D. in Bioengineering, The Pennsylvania State University (PSU),
University Park, PA, USA
1992
M.S. in Biomedical Engineering, Drexel University, Philadelphia, PA, USA
1992
M.S. in Electrical Engineering, Drexel University, Philadelphia, PA, USA
1986
B.S. in Biomedical Engineering, Chung Yuan Christian University (CYCU),
Chung Li, Taiwan
Experiences
2012/01-present
2011/08-present
2006/01-present
2009/08-2011/07
1998/082009/07
2003/08-2007/07
1998/0-1998/07
1997/07-1997/12
1997/02-1997/12
Vice Director, Computer and Network Center, NCKU
Professor, CSIE &IMI, NCKU
Secretary General, Taiwanese Society of Biomedical Engineering
Associate Professor, CSIE &IMI, NCKU
Assistant, Associate, and Professor in Department of Biomedical
Engineering, CYCU
Chairman, Department of Biomedical Engineering, CYCU
Post-doctoral fellow, NIH Ultrasonic Transducer Resource Center,
PSU
Research Associate, Department of Biomedical Engineering,
University of Virginia, Charlottesville, VA, USA
Research Engineer, CardioResearch Inc., Charlottesville, VA,
USA
Research Interests
Biomedical ultrasound signal and imaging
Ultrasonic tissue characterization
High-frequency ultrasound signal and imaging system
Ultrasound bio-effect
Ultrasound transducer and array engineering
Blood flow measurement
Ultrasound contrast agent applications
6
Selected publications
1.
Chih-Chung Huang, Yi-Hsun Lin, Ting-Yu Liu, and Shyh-Hau Wang*, “Study
of the Blood Coagulation by Ultrasound,” Journal of Medical and Biological
Engineering, 31(2): 79-86, 2011.
2.
Yi-Hsun Lin, Chih-Chung Huang, Shyh-Hau Wang*, “Quantitative assessments
of burn degree by high-frequency ultrasonic backscattering and statistical
model,” Physics in Medicine and Biology, 56:757–773, 2011.
C. C. Huang and S. H. Wang*, “Assessment of Blood Coagulation under
Various Flow Conditions with Ultrasound Backscattering,” IEEE Trans. on
3.
4.
5.
6.
7.
8.
9.
Biomedical Engineering, 54(12):2223-2230, 2007.
Chih-Chung Huang and Shyh-Hau Wang*, “Statistical variations of ultrasound
signals backscattered from flowing blood,” Ultrasound in medicine and
biology, 33(12):1943-1954, 2007.
C. C. Huang, S. H. Wang*, and P. H. Tsui, “Detection of blood coagulation and
clot formation using quantitative ultrasonic parameters,” Ultrasound in
Medicine and Biology, 31(11):1567-1573, 2005.
P. H. Tsui and S. H. Wang*, “The effect of transducer characteristics on the
estimation of Nakagami parameter as a function of scatterer concentration,”
Ultrasound in Medicine and Biology, 30(10):1345-1353, 2004.
S. H. Wang and K. K. Shung, “In vivo measurements of ultrasonic
backscattering in blood,” IEEE Trans. on Ultrasonics, Ferroelectrics and
Frequency Control, 48(2):425-431, 2001.
S. H. Wang, L. P. Lee, and J. S. Lee, “A linear relation between the
compressibility and density of blood,“ Journal of the Acoustical Society of
America, 109(1):390-396, 2001.
S. H. Wang and K. K. Shung, “An approach for measuring ultrasonic
backscattering from biological tissues with focused transducers,“ IEEE Trans.
on Biomedical Engineering, 44(7):549-554, 1997.
10. S. H. Wang, P. H. Chang, K. K. Shung, and H. Levene, “Some considerations on
the measurement of mean frequency shift and Integrated backscatter following
administration of Albunex®,“ Ultrasound in Medicine and Biology,
22(4):441-451, 1996.
7
High Frequency Ultrasound Technologies for
Characterizing Biological Tissuesand Materials
Lecture Time: 11:30-12:00
Shyh-Hau Wang
Professor, Department of Computer Science and Information Engineering &
Institute of medical Informatics
Secretary General, Taiwanese Society of Biomedical Engineering
Abstract
Ultrasound imaging is a well-known and wide-accepted modality able to
noninvasively discern the internal organs owing to its promising spatial resolution and
real-time capability. Without radiation risk, ultrasound image is frequently applied to
almost all fields of clinical applications. Yet, the quality of ultrasound image is worthy
of being improving. It is straightforward to improve ultrasound resolution by
increasing the employed frequency. However, the accompanying attenuation tends to
significantly limit the depth of high-frequency ultrasound penetration. In the current
presentation, fundamentals ultrasound imaging will be briefly introduced. More focus
will be stressed on the development of high-frequency ultrasound system. The related
applications and techniques on the characterization of characterize biological tissues
and other materials will be introduced.
8
Curriculum Vitae
Full Name: Yoshifumi Saijo
Birth Date: July 21, 1962
Birth Place: Yokohama, Japan
Sex: Male
Nationality: Japan
Home Address: 3-4-5 Nakayamadai, Aoba-ku, Sendai 989-3202, Japan
Phone (Home): +81-22-279-6645
Office Address: 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan
Phone (Office): +81-22-717-8514
Family: Wife, 22-year old son and 19-year old daughter
Education
March 1988: Graduate from School of Medicine, Tohoku University
March 1993: Received PhD (Medicine) from Graduate School of Medicine, Tohoku
University
Career
April 1993 – June 1995: Cardiologist, Department of Cardiology, Sendai Kosei
Hospital
July 1995 – June 1997: Chief Cardiologist, Department of Cardiology, Fukaya Public
Hospital
July 1997 – July 2004: Assistant Professor, Institute of Development, Aging and
Cancer, Tohoku University
January 1999 – June 1999: Guest Professor, Aarhus University, Denmark
August 2004 – March 2008: Associated Professor, Institute of Development, Aging
and Cancer, Tohoku University
April 2008 – Present: Full Professor, Graduate School of Biomedical Engineering,
Tohoku University
Publications
PhD Thesis: Measurement of physical properties of diseased myocardium by scanning
acoustic microscopy and its relation to pathophysiology (in Japanese). Karei Igaku
Kenkyusho Zasshi, Vol. 45, 67-85, 1994.
Journals
1. Saijo Y, Tanaka M, Okawai H, Dunn F. The ultrasonic properties of gastric cancer
tissues obtained with a scanning acoustic microscope system. Ultrasound Med
9
Biol Vol. 17, No. 7: 709-714, 1991.
2. Saijo Y, Tanaka M, Yamamoto A, Endo N, Takahashi K, Satoh N, Chiba S.
Estimation of intracardiac local flow state by two-dimensional display of the
stream lines. J Cardiol. Vol. 23, Suppl. XXXVII: 125-131, 1993.
3. Sasaki H, Saijo Y, Tanaka M, Okawai H, Terasawa Y, Yambe T, Nitta S. Influence
of tissue preparation on the high-frequency acoustic properties of normal kidney
tissue. Ultrasound Med Biol Vol. 22, No. 9: 1261-1265, 1996.
4. Sasaki H, Tanaka M, Saijo Y, Okawai H, Terasawa Y, Nitta S, Suzuki K.
Ultrasonic tissue characterization of renal cell carcinoma tissue. Nephron Vol. 74,
No. 1: 125-130, 1996.
5. Saijo Y, Tanaka M, Okawai H, Sasaki H, Nitta S, Dunn F. Ultrasonic tissue
characterization of infarcted myocardium by scanning acoustic microscopy.
Ultrasound Med Biol Vol. 23, No. 1: 77-85, 1997.
6. Sasaki H, Saijo Y, Tanaka M, Nitta S, Terasawa Y, Yambe T, Taguma Y. Acoustic
properties of dialysed kidney by scanning acoustic microscopy. Nephrol Dial
Transplant. Vol. 12, No. 10: 2151-2154, 1997.
7. Sasaki H, Saijo Y, Tanaka M, Nitta S, Yambe T, Terasawa Y. Characterization of
renal angiomyolipoma by scanning acoustic microscopy. J Pathol. Vol. 181, No.
4: 455-461, 1997.
8. Saijo Y, Sasaki H, Okawai H, Nitta S, Tanaka M. Acoustic properties of
atherosclerosis of human aorta obtained with high-frequency ultrasound.
Ultrasound Med Biol. Vol. 24, No. 7: 1061-1064, 1998.
9. Saijo Y, Izutsu K, Sonobe T, Okuyama Y, Yambe T, Nitta S. Successful closure of
coronary-bronchial artery fistula with vein graft-coated stent. Catheter Cardiovasc
Interv. Vol. 46, No. 2: 214-217, 1999.
10. Saijo Y, Jorgensen C, Falk E, Nitta S. Collagen characterization of fibrous caps in
Apo-E deficient mice by acoustic microscopy. Circulation Vol. 100, No. 18: I-251,
1999.
11. Saijo Y, Sasaki H, Sato M, Nitta S, Tanaka M. Visualization of human umbilical
vein endothelial cells by acoustic microscopy. Ultrasonics Vol. 38, No. 1-8:
396-399, 2000.
12. Saijo Y, Okawai H, Sasaki H, Yambe T, Nitta S, Tanaka M, Kobayashi K, Honda Y.
Evaluation of the inner-surface morphology of an artificial heart by acoustic
microscopy. Artif Organs. 2000 Vol. 24, No. 1: 64-69, 2000.
13. Saijo Y, Chubachi N. Microscopy. Ultrasound Med Biol. Vol. 26, Suppl. 1: S30-32,
2000.
14. Saijo Y, Jorgensen CS, Falk E. Ultrasonic tissue characterization of collagen in
lipid-rich plaques in apoE-deficient mice. Atherosclerosis Vol. 158, No. 2:
289-295, 2001.
15. Saijo Y, Ohashi T, Sasaki H, Sato M, Jorgensen CS, Nitta S. Application of
scanning acoustic microscopy for assessing stress distribution in atherosclerotic
10
plaque. Ann Biomed Eng, Vol. 29, No. 12: 1048-53, 2001.
16. Saijo Y, Jorgensen CS, Mondek P, Sefranek V, Paaske W. Acoustic inhomogeneity
of carotid arterial plaques determined by GHz frequency range acoustic
microscopy. Ultrasound Med Biol, Vol. 28, No. 7: 933-937, 2002.
17. Saijo Y, Akimoto H, Saiki Y, Tabayashi K, Horinouchi T, Kobayashi T, Nitta S.
Proximal (entry) tear of dissecting aortic aneurysm visualized by
three-dimensional echocardiography. J Thorac Cardiovasc Surg Vol. 124, No. 6:
1245-1246, 2002.
18. Sasaki H, Saijo Y, Tanaka M, Nitta S. Influence of tissue preparation on the
acoustic properties of tissue sections at high frequencies. Ultrasound Med Biol,
Vol. 29, No. 9: 1367-72, 2003.
19. Hozumi N, Yamashita R, Lee CK, Nagao M, Kobayashi K, Saijo Y, Tanaka M,
Tanaka N, Ohtsuki S. Ultrasonic sound speed microscope for biological tissue
characterization driven by nanosecond pulse. Acoust Sci Tech. Vol. 24, No. 6,
386-390, 2003.
20. Saijo Y, Miyakawa T, Sasaki H, Tanaka M, Nitta S. Acoustic properties of aortic
aneurysm obtained with scanning acoustic microscopy. Ultrasonics, Vol. 42, No.
1-9: 695-698, 2004.
21. Saijo Y, Nitta S, Kobayashi K, Arai H, Nemoto Y. Development of an
ultra-portable echo device connected to USB port. Ultrasonics, Vol. 42, No. 1-9:
699-703, 2004.
22. Hozumi N, Yamashita R, Lee CK, Nagao M, Kobayashi K, Saijo Y, Tanaka M,
Tanaka N, Ohtsuki S. Time–frequency analysis for pulse driven ultrasonic
microscopy for biological tissue characterization. Ultrasonics, Vol. 42, No. 1-9:
717-722, 2004.
23. Saijo Y, Tanaka A, Owada N, Akino Y, Nitta S. Tissue velocity imaging of
coronary artery by rotating-type intravascular ultrasound. Ultrasonics, Vol. 42, No.
1-9: 753-757, 2004.
24. Sano H, Saijo Y, Kokubun S. Material properties of the supraspinatus tendon at its
insertion – A measurement with the scanning acoustic microscopy. J
Musculoskeletal Res Vol. 8, No. 1: 29-34, 2004.
25. Suzuki S, Hao B, Matsuda Y, Tabata T, Hoshikawa Y, Saijo Y, Kondo T. Paclitaxel
prevents loss of pulmonary endothelial barrier integrity during cold preservation.
Transplantation Vol. 78, No. 4: 524-529, 2004.
26. Funamoto K, Hayase T, Saijo Y, Yambe T. Detection and correction of aliasing in
ultrasonic measurement of blood flows with Ultrasonic-Measurement-Integrated
simulation. Technol Health Care. Vol 13, No.4: 331-44, 2005.
27. Saijo Y, Sasaki H, Hozumi N, Kobayashi K, Tanaka M, Yambe T. Sound speed
scanning acoustic microscopy for biomedical applications. Technol Health Care.
Vol. 13, No. 4: 261-7, 2005.
28. Funamoto K, Hayase T, Shirai A, Saijo Y, Yambe T. Fundamental study of
11
ultrasonic-measurement-integrated simulation of real blood flow in the aorta. Ann
Biomed Eng. Vol. 33, No. 4: 415-28, 2005.
29. Watanabe S, Suzuki N, Kudo A, Suzuki T, Abe S, Suzuki M, Komatsu S, Saijo Y,
Murayama N. Influence of aging on cardiac function examined by
echocardiography. Tohoku J Exp Med. Vol. 207, No.1: 13-9, 2005.
30. Santos Filho E, Yoshizawa M, Tanaka A, Saijo Y, Iwamoto T. Moment based
texture segmentation of intravascular ultrasound images. J Med Ultrasonics. Vol.
32, No. 3: 91-99, 2005.
31. Dos Santos E, Yoshizawa M, Tanaka A, Saijo Y, Iwamoto T. Detection of luminal
contour using fuzzy clustering and mathematical morphology in intravascular
ultrasound images. Conf Proc IEEE Eng Med Biol Soc. Vol. 4: 3471-4, 2005.
32. van der Steen AFW, Baldewsing RA, Degertekin FL, Emelianov S, Frijlink ME,
Furukawa Y, Goertz D, Karaman M, Khuri-Yakub PT, Kim K, Mastik F, Moriya T,
Oralkan O, Saijo Y, Schaar JA, Serruys PW, Sethuraman S, Tanaka A, Vos HJ,
Witte R, O’Donnell M. IVUS beyond the horizon. Eurointerv, Vol. 2: 132-142,
2006.
33. Sano H, Hattori K, Saijo Y, Kokubun S. Does decalcification alter the tissue sound
speed of rabbit supraspinatus tendon insertion? In vitro measurement using
scanning acoustic microscopy. Ultrasonics, Vol. 44, No. 3: 297-301, 2006.
34. Saijo Y, Hozumi N, Lee C, Nagao M, Kobayashi K, Oakada N, Tanaka N, Santos
Filho ED, Sasaki H, Tanaka M, Yambe T. Ultrasonic speed microscopy for
imaging of coronary artery. Ultrasonics, Vol. 44; Suppl. 1: e51-55, 2006.
35. Saijo Y, Tanaka A, Iwamoto T, Dos Santos Filho E, Yoshizawa M, Hirosaka A,
Kijima M, Akino Y, Hanadate Y, Yambe T. Intravascular two-dimensional tissue
strain imaging. Ultrasonics, Vol. 44; Suppl. 1: e147-151, 2006.
36. Sano H, Saijo Y, Kokubun S. Non-mineralized fibrocartilage shows the lowest
elastic modulus in the rabbit supraspinatus tendon insertion: measurement with
scanning acoustic microscopy. J Shoulder Elbow Surg, Vol. 15, No. 6: 743-749,
2006.
37. Hagiwara Y, Saijo Y, Chimoto E, Akita H, Sasano Y, Matsumoto F, Kokubun S.
Increased elasticity of capsule after immobilization in a rat knee experimental
model assessed by scanning acoustic microscopy. Upsala J Med Sci. Vol. 111, No.
3: 303-313, 2006.
38. Saijo Y, Hozumi N, Kobayashi K, OkadaN, Santos Filho ED, Sasaki H, Yambe T,
Tanaka M. Ultrasonic tissue characterization of atherosclerosis by a
speed-of-sound microscanning system. IEEE Trans Ultrason Ferroelectr Freq
Control. Vol. 54, No. 8: 1571-1577, 2007.
39. Hattori K, Sano H, Saijo Y, Kita A, Hatori M, Kokubun S, Itoi E. Measurement of
soft tissue elasticity in the congenital clubfoot using scanning acoustic microscope.
J Pediatr Orthop B. Vol. 16, No. 5: 357-362, 2007.
40. Tanaka A, Saijo Y. Blood flow visualization of left atrial spontaneous echo
12
contrast (SEC) using gradient based optical flow estimation. Conf Proc IEEE Eng
Med Biol Soc. Vol. 1: 4500-3, 2007.
41. Saijo Y, Hozumi N, Kobayashi K, Okada N, Ishiguro T, Hagiwara Y, Dos Santos
Filho E, Yambe T. Ultrasound speed and impedance microscopy for in vivo
imaging. Conf Proc IEEE Eng Med Biol Soc. Vol. 1: 1350-3, 2007.
42. Liu H, Luo Y, Higa M, Zhang X, Saijo Y, Shiraishi Y, Sekine K, Yambe T.
Biochemical evaluation of an artificial anal sphincter made from shape memory
alloys. J Artif Organs. Vol. 10: 223-227, 2007.
43. Okazaki T, Ebihara S, Asada M, Yamanda S, Saijo Y, Shiraishi Y, Ebihara T, Niu
K, Mei H, Arai H, Yambe T. Macrophage colony-stimulating factor improves
cardiac function after ischemic injury by inducing vascular endothelial growth
factor production and survival of cardiomyocytes. Am J Pathol. Vol. 171, No. 4:
1093-1103, 2007.
44. Santos Filho E, Saijo Y, Tanaka A, Yambe T, Yoshizawa M. Fractal dimension of
40 MHz intravascular ultrasound radio frequency signals. Ultrasonics, Vol. 48, No.
1, 35-39, 2008.
45. Santos Filho E, Saijo Y, Tanaka A, Yoshizawa M. Detection and quantification of
calcifications in intravascular ultrasound images by automatic thresholding.
Ultrasound Med Biol. Vol. 34, No. 1: 160-165, 2008.
46. Saijo Y, Kobayashi K, Okada N, Hozumi N, Hagiwara Y, Tanaka A, Iwamoto T.
High frequency ultrasound imaging of surface and subsurface structures of
fingerprints. Conf Proc IEEE Eng Med Biol Soc. 2008: 2173-2176, 2008.
47. Iwamoto T, Saijo Y, Hozumi N, Kobayashi K, Okada N, Tanaka A, Yoshizawa M.
High frequency ultrasound characterization of artificial skin. Conf Proc IEEE Eng
Med Biol Soc. 2008: 2185-2188, 2008.
48. Funamoto K, Hayase T, Saijo Y, Yambe T. Numerical experiment for
ultrasonic-measurement-integrated simulation of three-dimensional unsteady
blood flow. Ann Biomed Eng. Vol. 36, No. 8: 1383-97, 2008.
49. Mineta M, Sano H, Ichinose R, Saijo Y, Itoi E. Elasticity of the supraspinatus
tendon-muscle unit is preserved after acute tendon tearing in the rabbit. Tohoku J
Exp Med. Vol. 216, No. 1: 17-24, 2008.
50. Hagiwara Y, Ando A, Chimoto E, Saijo Y, Ohmori-Matsuda K, Itoi E. Changes of
articular cartilage after immobilization in a rat knee contracture model. J Orthop
Res. Vol. 27, No. 2: 236-242, 2009.
51. Funamoto K, Hayase T, Saijo Y, Yambe T. Numerical Experiment of Transient and
Steady Characteristics of Ultrasonic-Measurement-Integrated Simulation in
Three-Dimensional Blood Flow Analysis. Ann Biomed Eng. Vol. 37, No. 1: 34-49,
2009.
52. Hagiwara Y, Saijo Y, Ando A, Chimoto E, Suda H, Onoda Y, Itoi E. Ultrasonic
intensity microscopy for imaging of living cells. Ultrasonics Vol. 49, No. 3:
386–388, 2009.
13
53. Kijima H, Minagawa H, Saijo Y, Sano H, Tomioka T, Yamamoto N, Shimada Y,
Okada K, Itoi E. Degenerated coracoacromial ligament in shoulders with rotator
cuff tears shows higher elastic modulus: measurement with scanning acoustic
microscopy. J Orthop Sci. Vol. 14, No.1: 62-7, 2009.
54. Saijo Y. Acoustic microscopy: latest developments and applications. Imaging in
Medicine, Vol. 1, No. 1, 47-63, 2009.
55. Takayama S, Seki T, Watanabe M, Monma Y, Yang SY, Sugita N, Konno S, Saijo
Y, Yambe T, Yaegashi N, Yoshizawa M, Nitta S. Brief effect of acupuncture on the
peripheral arterial system of the upper limb and systemic hemodynamics in
humans. J Altern Complement Med, Vol. 16, No. 7, 707-713, 2010.
56. Takayama S, Seki T, Sugita N, Konno S, Arai H, Saijo Y, Yambe T, Yaegashi N,
Yoshizawa M, Nitta S. Radial artery hemodynamic changes related to acupuncture.
EXPLORE, Vol. 6, No. 2, 100-105, 2010.
57. Nakajima H, Sugawara S, Kameyama T, Tabuchi H, Ohtsuki S, Tanaka M, Saijo Y.
Location of flow axis line in the left ventricle and its interaction with local
myocardial motion. J Echocardiogr, Vol. 9, No. 1, 24-27, 2011.
58. Ando A, Suda H, Hagiwara Y, Onoda Y, Chimoto E, Saijo Y, Itoi E. Reversibility
of immobilization-induced articular cartilage degeneration after remobilization in
rat knee joints. Tohoku J Exp Med. Vol. 224, No. 2, 77-85, 2011.
59. Kumagai K, Koike H, Kudo Y, Nagaoka R, Kubo K, Kobayashi K, Saijo Y.
Imaging of sebaceous glands of human skin by three-dimensional ultrasound
microscopy and its relation to elasticity. Conf Proc 33rd IEEE Eng Med Biol Soc.
7199-7202, 2011.
60. Tanoue H, Hagiwara Y, Kobayashi K, Saijo Y. Ultrasonic tissue characterization
of prostate biopsy tissues by ultrasound speed microscope. Conf Proc 33rd IEEE
Eng Med Biol Soc. 8499-8402, 2011.
61. Hagiwara Y, Saijo Y, Ando A, Onoda Y, Suda H, Chimoto E, Hatori K, Itoi E.
Comparison of articular cartilage images assessed by high-frequency ultrasound
microscope and scanning acoustic microscope. Int Orthop. Vol. 6, No. 1, 185-90,
2012.
62. Tanaka Y, Saijo Y, Fujihara Y, Yamaoka H, Nishizawa S, Nagata S, Ogasawara T,
Asawa Y, Takato T, Hoshi K. Evaluation of the implant type tissue-engineered
cartilage by scanning acoustic microscopy. J Biosci Bioeng. 2011 Dec 2. [Epub
ahead of print]
Books
1. Saijo Y, Okawai H, Sasaki H, Naganuma T, Tanaka M. Intravascular ultrasound
and scanning acoustic microscopy evaluation of aortic wall. Joie Pierce Jones ed.
Acoustical Imaging Vol. 21, Plenum Publishing Corporations, 423-432, 1995.
2. Saijo Y, Sasaki H, Okawai H, Tanaka M. Development of ultrasonic spectroscopy
14
for biomedical use. Piero Tortoli and Leonard Masotti eds. Acoustical Imaging Vol.
22, Plenum Publishing Corporations; 335-340, 1995.
3. Sasaki H, Saijo Y, Okawai H, Terasawa Y, Nitta S, Tanaka M. Acoustic properties
of renal cell carcinoma tissues. Piero Tortoli and Leonard Masotti eds. Acoustical
Imaging Vol. 22, Plenum Publishing Corporations; 185-190, 1995.
4. Ultrasonic Tissue Characterization. Dunn F, Tanaka M, Ohtsuki S, Saijo Y eds.
Springer-Verlag, Tokyo, 1996.
5. Saijo Y, Sasaki H. High frequency acoustic properties of tumor tissue. Ultrasonic
Tissue Characterization, Springer-Verlaq Tokyo, 217-229, 1996.
6. Saijo Y, Sasaki H, Okawai H, Nitta S, Tanaka M. Visualization of living cells by
acoustic microscopy. Sidney Lees and Leonard A. Ferrari eds. Acoustical Imaging
Vol. 23, Plenum Publishing Corporations; 7-12, 1997.
7. Saijo Y, Sasaki H, Okawai H, Kataoka N, Sato M, Nitta S, Tanaka M. Acoustic
microscopy evaluation of endothelial cells modulated by fluid shear stress. Hua
Lee ed. Acoustical Imaging. Vol. 24, Plenum Publishing Corporations /Kluwer
Academic Publishers; 157-163, 2000.
8. Saijo Y, Jorgensen CS, Falk E. Characterization of collagen fibers in
atherosclerotic plaques in mice. Michael Halliwell and Peter N. T. Wells eds.
Acoustical Imaging. Vol. 25, Plenum Publishing Corporations /Kluwer Academic
Publishers; 363-368, 2000.
9. Saijo Y, Iguchi A, Tabayashi K, Kobayashi K, Sasaki H, Tanaka A, Hozumi N,
Nitta S. Detecting cardiac allograft rejection by acoustic microscopy. Roman Gr.
Maev ed. Acoustical Imaging Vol. 26, Plenum Publishing Corporations /Kluwer
Academic Publishers; 105-110, 2002.
10. Vascular Ultrasound. Saijo Y, van der Steen AFW eds. Springer, Tokyo, 2003.
11. Saijo Y. Evaluation of atherosclerosis by acoustic microscopy. Vascular
Ultrasound, Springer-Verlaq Tokyo, 310-326, 2003.
12. Saijo Y. Ultrasonic measurement of micro-acoustic properties of the biological
soft materials. Dominique Placko and Tribikram Kundu eds. Ultrasonic Methods
for Material Characterization, Lavoisier, 39-58, 2003.
13. Saijo Y. Clinical applications of ultrasonic nondestructive evaluation. Tribikram
Kundu ed. Ultrasonic Nondestructive Evaluation: Engineering and Biological
Material Characterization, CRC Press, 783-812, 2003.
14. Saijo Y, Miyakawa T, Sasaki H, Tanaka M, Nitta S. Acoustic and mechanical
properties of aortic aneurysms assessed by scanning acoustic microscopy. W.
Arnold and S. Hirsekorn eds. Acoustical Imaging Vol. 27, Kluwer Academic
Publishers; 479-483, 2004.
15. Hozumi N, Yamashita R, Lee C-K, Nagano M, Kobayashi K, Saijo Y, Tanaka M,
Tanaka N, Ohtsuki S. Ultrasonic sound speed microscope for biological tissue
characterization driven by nanosecond pulse. W. Arnold and S. Hirsekorn eds.
Acoustical Imaging Vol.27, Kluwer Academic Publishers, 495-501, 2004.
15
16. Saijo Y, Tanaka A, Sasaki H, Iwamoto T, Santos Filho E, Yoshizawa M, Yambe T.
Basic ultrasonic characteristics of atherosclerosis measured by intravascular
ultrasound and acoustic microscopy. Kouichi Itoh ed. State of the Art: Ultrasonics
in Medicine. International Congress Series 1274, Elsevier, 116-121, 2004.
17. Saijo Y. Ultrasonic measurement of micro-acoustic properties of the biological
soft materials. Tribikram Kundu ed. Advanced Ultrasonic Methods for Material
Characterization, ISTE, 89-113, 2007.
18. Iwamoto T, Saijo Y, Tanaka A, Santos Filho E, Li S, Yoshizwa M. Radio
frequency signal analysis for tissue characterization of coronary artery: In vivo
intravascular ultrasound study. Iwaki Akiyama ed. Acoustical Imaging Vol 29,
Springer, 147-152, 2008.
19. Saijo Y, Hozumi N, Kobayashi K, Okada N, Hagiwara Y, Sasaki H, Santos Filho E,
Yambe T. Ultrasonic nano-imaging system for medicine and biology. Iwaki
Akiyama ed. Acoustical Imaging Vol 29, Springer, 181-186, 2008.
20. Hagiwara Y, Chimoto E, Ando A, Saijo Y, Itoi E. Elastic changes of capsule in a
rat knee contracture model assessed by scanning acoustic microscopy. Iwaki
Akiyama ed. Acoustical Imaging Vol 29, Springer, 187-192, 2008.
Grants
1. Grants-in-Aid for Scientific Research (Challenging Exploratory Research A) from
the Japan Society for the Promotion of Science: Development of biomechanics of
the vascular endothelium by high frequency ultrasound, 1998-1999, 2,000,000
JPY.
2. Grants-in-Aid for Scientific Research (Challenging Exploratory Research A) from
the Japan Society for the Promotion of Science: Transfer of information to
vascular endothelial cells by low intensity ultrasound, 2000-2001, 2,100,000 JPY.
3. Grants-in-Aid for Scientific Research (Scientific Research B) from the Japan
Society for the Promotion of Science: Development of intravascular acoustic
microscopy, 2001-2003, 8,000,000 JPY.
4. Grants-in-Aid for Scientific Research (Scientific Research B) from the Japan
Society for the Promotion of Science: Nano-imaging of vascular endothelial cells
by ultrasound, 2001-2003, 12,600,000 JPY.
5. Grants from the Ministry of Health, Labor and Welfare for the Research on
Advanced Medical Technology: Development of in vivo nano-imaging, 2005-2007,
60,000,000 JPY.
6. Grants from New Energy and Industrial Technology Development Organization:
High frequency ultrasound imaging for evaluation of regenerated tissue,
2006-2009, 40,000,000 JPY.
7. Grants-in-Aid for Scientific Research (Scientific Research B) from the Japan
Society for the Promotion of Science: Assessment of angiogenesis by
16
high-resolution 3D molecular imaging, 2007-2009, 17,420,000 JPY.
8. Sendai Advanced Preventive Health Care Services Cluster from the Ministry of
Education, Culture, Sports, Science, 2007-2011, 56,565,000 JPY.
9. Grants-in-Aid for Scientific Research (Challenging Exploratory Research) from
the Japan Society for the Promotion of Science: Development of photoacoustic
imaging for visualization of vasa vasorum, 2009-2010, 3,200,000 JPY.
10. Grants-in-Aid for Scientific Research (Scientific Research B) from the Japan
Society for the Promotion of Science: Assessment of smart-aging of the skin by
tracking of the acoustic radiation force with high-frequency ultrasound,
2010-2012, 12,800,000 JPY.
11. Tohoku University Global COE Programme “Global Nano-Biomedical
Engineering Education and Research Network Centre”, 2009-2012, 1,200,000
JPY.
12. Technology and Regional Innovation Program from the Ministry of Economy,
Trade and Industry: Development of high-frequency ultrasound array probe for
skin evaluation, 2010-2011, 135,000,000 JPY.
13. Grants-in-Aid for Scientific Research (Challenging Exploratory Research) from
the Japan Society for the Promotion of Science: Development of sonocytometry,
2011-2012, 3,000,000 JPY.
17
Advanced Biomedical Ultrasound Technologies to Explore
Cardiovascular Dynamics and Biomechanics
Lecture Time: 12:00-12:30
Yoshifumi Saijo
Biomedical Imaging Laboratory, Graduate School of Biomedical Engineering,
Tohoku University
Abstract
Advanced biomedical ultrasound technologies enable 1) high resolution imaging with
high frequency ultrasound, 2) blood flow measurement based on Doppler techniques,
and 3) tissue characterization by multi-parameter analysis of the intravascular
ultrasound (IVUS) signal.
Biomedical acoustic microscopy represents 2D distribution of sound speed by
frequency-domain analysis of a single pulse with a high-speed digitizer.
Measurements of acoustic properties in myocardial infarction and atherosclerosis
provide useful information not limited in the interpretation of clinical ultrasound
images but also for the assessment of biomechanics because the square of sound
speed is proportional to tissue elasticity.
The information of the blood flow structure in left ventricle (LV) is obtained with
Echo-Dynamography in which 2D distribution of blood flow vector is deduced by
applying fluid dynamics theories to Doppler velocity datasets. B-mode movie was
processed for the optical flow method to obtain myocardial tissue velocity distribution.
On the assumption that the blood is incompressible fluid, the energy generated by
cardiac wall motion is directly transmitted to the intracardiac blood flow.
Multi-parameter analysis of intravascular ultrasound (IVUS) characterizes the tissue
components in coronary artery. Integrated backscatter (IB), Virtual Histology (VH),
strain rate imaging and newly developed method named “attenuation imaging” are
compared and discussed the interpretation by acoustic microscopy observations.
Passions of biomedical researchers to find the new horizons in pathophysiology are
important for future progression of biomedical ultrasound imaging.
18
Curriculum Vitae
Yoichi Haga was born in Sendai, Japan, on April 4, 1965. He received the M.D. in
1992 at Tohoku University School of Medicine, Sendai. From 1994 to 1996, he was
with Tohoku Kosei-Nenkin Hospital. From 1996 to 2002, he was a Research
Associate in the Department of Mechatronics and Precision Engineering, Tohoku
University. He received the Ph.D. degree from Graduate School of Engineering,
Tohoku University in 2002. From 2003 to 2004, he was an Assistant Professor in the
Department of Bioengineering and Robotics, Tohoku University. From 2004 to 2008,
he was an Associate Professor in the Tohoku University Biomedical Engineering
Research Organization (TUBERO). He received the Ph.D. degree from Tohoku
University School of Medicine in 2008. He is currently Professor in Graduate School
of Biomedical Engineering, Tohoku University. He has been studying
micromachining and nanomachining for medical and welfare applications (mainly
minimally invasive diagnosis and treatment).
Medical Devices for Minimally Invasive Diagnosis and Therapy
Using Micro/nano Fabrication Technology
Lecture Time: 13:30-14:00
Yoichi Haga
Abstract
Medical tools for use in the human body, such as catheters and endoscopic tools need
to be thin and small. With the progress of minimally invasive diagnostics and
treatment techniques, these medical tools must not only be thin or small, but must also
be capable of performing several functions. To meet these demands, microfabrication
techniques such as MEMS (Micro Electro Mechanical Systems) technology, in
addition to new fabrication technology, are effective. A MEMS device can incorporate
several functions, such as sensor, actuator, and microelectronics. We have developed
several microsensors and microactuation systems for mounting in intravascular and
endoscopic medical tools for the realization of high-performance and multifunctional
minimally invasive medical tools Active bending catheters have been developed for
steering catheter tips without using traction of wires from outside the body. An
ultrasonic therapeutic tool for sonodynamic therapy and sonoporation, and a micro
scanner for precise laser treatment have been developed as therapeutic tools for use in
the human body. High-functionalized endoscopic tools and catheters will enable more
precise and safe diagnostics and therapy, as well as novel diagnostics and treatment
which have been impossible to date.
19
Curriculum Vitae
YIH-FAN CHEN
Assistant Professor
Department of Biomedical Engineering, National Cheng Kung University
No.1, University Road, Tainan City 701, Taiwan (R.O.C.)
Phone: +886-6-275-7575 #63434 Email: chenyf@mail.ncku.edu.tw
EDUCATION
Ph.D. ‒ University of Michigan, Ann Arbor, MI, USA, Apr. 2010
Department of Biomedical Engineering
Advisor: Prof. Jens-Christian Meiners
M.S. ‒ University of Michigan, Ann Arbor, MI, USA, Apr. 2007
Department of Biomedical Engineering
Concentration: Bioelectronics
Advisor: Prof. Jens-Christian Meiners
M.S. ‒ National Taiwan University, Taipei, Taiwan, July 2004
Institute of Applied Mechanics
Advisor: Prof. Chih-Kung Lee
B.S. ‒ National Taiwan University, Taipei, Taiwan, June 2002
Department of Civil Engineering
RESEARCH & WORK EXPERIENCE
Assistant Professor, Aug. 2010 – Present
Department of Biomedical Engineering
National Cheng Kung University, Tainan, Taiwan
Postdoctoral Fellow, July 2010 – July 2011
Kavli Institute at Cornell for Nanoscale Science, Ithaca, NY, USA
Supervisors: Prof. David Erickson, Prof. Michal Lipson
Technical Consultant, Dec. 2010 – July 2011
Optofluidics, Inc., Ithaca, NY, USA
Research Assistant , June 2006 – May 2010
Department of Biomedical Engineering
University of Michigan, Ann Arbor, MI, USA
Advisor: Prof. Jens-Christian Meiners
Research Assistant, June 2002 – July 2005
Institute of Applied Mechanics
National Taiwan University, Taipei, Taiwan
Advisor: Prof. Chih-Kung Lee
20
HONORS & AWARDS
Postdoctoral Fellow at Kavli Institute at Cornell (KIC) for Nanoscale Science,
July 2010 – Present
Awarded to outstanding researchers in nanoscale science to create new techniques to
image and dynamically control nanoscale systems and uses these techniques to push
the frontiers of nanoscale science
Outstanding College Youth, 2004
National Taiwan University, Taipei, Taiwan
Awarded to seven students from the entire university for best all-round achievements
in academic and extra-curricular activities
Best Originality Award, 2002
TiC100 Entrepreneurship Competition, Advantech Foundation, Taiwan
Awarded to the team that presented the most original technology
PUBLICATIONS
Journal Publications
Chen, Y.F., Serey, X., Sarkar, R., Chen, P. & Erickson, D. Controlled photonic
manipulation of proteins and other nanomaterials. Nano Lett. (Accepted 2012)
Serey, X., Mandal, S, Chen, Y.F. & Erickson, D. DNA transport and delivery in
thermal gradients near optofluidic resonators. Phys. Rev. Lett. 108, 048102 (2012).
Erickson, D., Serey, X., Chen, Y.F. & Mandal, S. Nanomanipulation using near field
photonics. Lab Chip 11, 995-1009 (2011). (Selected as inside front cover image)
Milstein, J.N., Chen, Y.F. & Meiners, J.-C. Bead size effects on protein-mediated
DNA looping in tethered-particle motion experiments. Biopolymers 95, 144-150
(2011).
Chen, Y.F., Milstein, J.N. & Meiners, J.-C. Protein-mediated DNA loop formation and
breakdown in a fluctuating environment. Phys. Rev. Lett. 104, 258103 (2010).
Chen, Y.F., Milstein, J.N. & Meiners, J.-C. Femtonewton entropic forces can control
the formation of protein-meditated DNA loops. Phys. Rev. Lett. 104, 048301 (2010).
(Designated as an Editors’ Suggestion and spotlighted with an editorial Synopsis;
reported in Genome Technology Magazine, Discovery News, and United Press
International.)
Chen, Y.F., Wilson, D.P., Raghunathan, K. & Meiners, J.-C. Entropic boundary effects
on the elasticity of short DNA molecules. Phys. Rev. E 80, 020903(R) (2009). (Also
selected for the September 1, 2009 issue of Virtual Journal of Biological Physics
Research)
Chen, Y.F., Blab, G.A. & Meiners, J.-C. Stretching sub-micron biomolecules with
constant-force axial optical tweezers. Biophys. J. 96, 4701-4708 (2009).
Patents and Invention Disclosures
Erickson, D. & Chen, Y.F., Optical trapping apparatus, methods and applications
using photonic crystal resonators. (under review)
21
Hsu, Y.H., Hsiao, W.H., Wu, W.J., Lee, C.K., Cheng, C.C., Chen, Y.F., Chen, C.K.,
Tsai, F.J. & Huang, C.T. Apparatus and method for mounting a piezoelectric
transducer on a print circuit board. R.O.C. Patent I288588 (2007).
Hsu, C.H., Rao, H., Lee, C.K., Wu, W.J., Hsiao, W.H., Chen, C.K., Chen, Y.F., Chen,
Y.C. & Hung, J.N. Alert system and method for geographic or natural disasters
utilizing a telecommunications network. R.O.C. Patent I284864 (2007).
Jin, M.H., Kao, C.Y., Chen, Y.F., Wu, W.J. & Lee, C.K. Structure and management of
automatic hierarchical sensor networks. R.O.C. Patent I253252 (2006).
Hsu, C.H., Rao, H., Lee, C.K., Wu, W.J., Hsiao, W.H., Chen, C.K., Chen, Y.F., Chen,
Y.C. & Hung, J.N. Alert system and method for geographic or natural disasters
utilizing a telecommunications network. U.S. Patent 6914525 (2005).
Contributed Conference Publications/Presentations
Raghunathan, K., Chen, Y.F., Blaty, J., Juliar, B.A., Milstein, J.N. & Meiners, J.-C.
Mechanics of DNA : sequence dependent elasticity. SPIE NanoScience + Engineering,
San Diego, CA, USA (Aug 2011). Proc. SPIE 8097, 80970C (2011).
Chen, Y.F. & Erickson, D. Nanomanipulation using near field photonics. OSA Optical
Trapping Applications, Montery, CA, USA (Apr 2011). (invited talk)
Raghunathan, K., Chen, Y.F., Milstein, J.N., Juliar, B.A., Blaty, J. & Meiners, J.-C.
Insights into sequence dependent effects on DNA elasticity using single molecule
techniques. Biophysical Society Meeting, Baltimore, USA (Mar 2011).
Chen, Y.F., Serey, X., Mandal, S. & Erickson, D. Nanomanipulation using silicon
nitride photonic crystal resonators. IEEE Winter Topicals, Keystone, CO, USA (Jan
2011). (podium presentation)
Chen, Y.F., Milstein, J.N. & Meiners, J.-C. Protein-mediated DNA looping in a
fluctuating micromechanical environment. SPIE NanoScience + Engineering, San
Diego, CA, USA (Aug 2010) Proc. SPIE 7762, 77620B (2010).
Raghunathan, K., Chen, Y.F., Milstein, J.N., Juliar, B.A., Blaty, J. & Meiners, J.-C.
Sequence dependent DNA elasticity. Midwest Single-Molecule Workshop,
Washington University-St. Louis, St. Louis, MO, USA (July 2010).
Chen, Y.F., Milstein, J.N. & Meiners, J.-C. Fluctuating forces facilitate
protein-mediated DNA looping.
Biophysical Society Meeting, San Francisco, CA, USA (Feb 2010). (poster
presentation)
Chen, Y.F., Raghunathan, K., Wilson, D.P. & Meiners, J.-C. Boundary-condition
dependent elasticity of short double-stranded DNA molecules. SPIE NanoScience +
Engineering, San Diego, CA, USA (Aug 2009). Proc. SPIE 7400, 740003 (2009).
Chen, Y.F., Wilson, D.P., Raghunathan, K. & Meiners, J.-C. Elasticity of sub-micron
DNA molecules studied with axial optical tweezers. Biophysical Society Meeting,
Boston, MA, USA (Feb 2009). (poster presentation)
22
Chen, Y.F., Blab, G.A., Wilson, D.P. & Meiners, J.-C. The effect of femtonewton
forces on protein-mediated DNA looping. Biophysical Society Meeting, Long Beach,
CA, USA (Feb 2008). (poster presentation)
Chen, Y.F., Blab, G.A. & Meiners, J.-C. Stretching sub-micron DNA fragments with
optical tweezers. SPIE NanoScience + Engineering, San Diego, CA, USA (Aug 2007).
Proc. SPIE 6644, 664403 (2007). (invited paper)
Chen, Y.F., Blab, G.A. & Meiners, J.-C. Stretching sub-micron DNA fragments with
optical tweezers. Biophysical Society Meeting, Baltimore, MD, USA (Feb 2007).
(poster presentation)
Blab, G.A., Wilson, D.P., Chen, Y.F. & Meiners, J.-C. Sequence-dependent variation
of DNA stiffness and its role in modulating DNA-protein interaction. Biophysical
Society Meeting, Baltimore, MD, USA (Feb 2007). (poster presentation)
TEACHING EXPERIENCE
Biophotonics (P880600 - Graduate)
Department of Biomedical Engineering, National Cheng Kung University
Instructor (Fall 2011)
Introduction to Computers (F910900- Undergraduate)
Department of Biomedical Engineering, National Cheng Kung University
Instructor (Fall 2011)
Biomedical Instrumentation (BME458- Graduate)
Department of Biomedical Engineering, University of Michigan, Ann Arbor
Teaching Assistant, Occasional Lecture (Winter 2008, Winter 2009, Winter 2010)
RESEARCH GROUP
Ph.D. Students
Jason Liu, M.D. (2011 – Present)
M.S. Students
Tai-Wei Su (2011 – Present)
Jen-Chiuan Yu (2011 – Present)
23
Nanomanipulation Using Near Field Photonics
Lecture Time: 14:00-14:30
Yih-Fan Chen
Medical Device Innovation Center and Department of Biomedical Engineering,
National Cheng Kung University, Tainan 701, Taiwan
Abstract
The ability to controllably handle the smallest materials is a fundamental enabling
technology for nanoscience. Conventional optical tweezers have proven useful for
manipulating microscale objects but cannot exert enough force to manipulate
dielectric materials smaller than about 100 nm. Recently, several near-field optical
trapping techniques have been developed that can provide higher trapping stiffness,
but they tend to be limited in their ability to reversibly trap and release smaller
materials due to a combination of the extremely high electromagnetic fields and the
resulting local temperature rise. Here, we have developed a new form of photonic
crystal “nanotweezer” that can trap and release on-command Wilson disease proteins,
quantum dots, and 22-nm polymer particles with a temperature rise less than ~0.3 K,
below the point where unwanted fluid mechanical effects will prevent trapping or
damage biological targets.
24
Curriculum Vitae
PERSONAL DETAILS
Title : Dr.
First Name : Takuji
Surname : Ishikawa
Date of Birth : 21 November, 1971
Address : 6-6-01, Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
Email : ishikawa@pfsl.mech.tohoku.ac.jp
Telephone : +81-22-795-4009
Fax : +81-22-795-6959
Nationality : Japan
Country of Birth : Japan
CAREER SUMMARY
Academic position : Associate Professor
Department : Bioengineering and Robotics
Start date of present employment : 1 April, 2006
Institution : Tohoku University
Field of specialisation: Biomechanics, Fluid Mechanics, Biophysics
Subject : Bio-fluid Mechanics
Date PhD awarded : 23 March, 1999
Statement of academic qualifications & career :
EDUCATION
1999 : Doctour's Degree in Mechanical Eng.. Tokyo Institute of Technology, Japan
1996 : Master's Degree in Mechanical Eng., Tokyo Institute of Technology, Japan
1994 : Bachelor's Degree in Mechanical Eng., Tokyo Institute of Technology, Japan
EXPERIENCE
2006-present : Associate Professor in the Dept. Bioengineering and Robotics, Tohoku
University, Japan
2003-2005 : Visiting Researcher in the Dept. Applied Mathematics and Theoretical
Physics, University of Cambridge, UK.
2002-2006 : Associate Professor in the Dept. Mechanical Engineering, Fukui
University, Japan
1999-2002 : Research Associate in the Dept. Mechanical Engineering, Fukui
University, Japan
25
1997-1999 : Research Fellow of the Japan Society for the Promotion of Science
HONORS AND AWARDS
2010 : Best paper award, Japanese Society for Engineering Education
2010 : Young investigator award, Miyagi Sangyo Kagaku Sinkou Kikin
2010 : The Young Scientists’ Prize, The Commendation for Science and Technology
by the Minister of Education,Culture, Sports, Science and Technology
2007 : Seguchi Award, Bioengineering Division, The Japan Society of Mechanical
Engineers
2003 : JSME Education Award, The Japan Society of Mechanical Engineers
1999 : JSME Young Engineers Award, The Japan Society of Mechanical Engineers
1996 : White Star Award, Dept. Mechanical Eng. and Sci., Tokyo Institute of
Technology
1994 : White Star Award, Dept. Mechanical Eng. and Sci., Tokyo Institute of
Technology
Transport Phenomena in Suspensions of Biological Cells
Lecture Time: 14:30-15:00
T. Ishikawa
Abstract
Biological cells, such as blood cells and bacteria, play a vital role in many medical
and environmental phenomena. Biological cells may deform or swim, which often
results in migration or coherent structures in the suspension. It has shown that
macroscopic properties of a suspension, such as rheological and diffusion properties,
are strongly affected by mesoscale flow structures generated by the cells. Since the
mesoscale flow structures are strongly affected by the interactions between cells, a
bottom-up strategy, i.e. from a cellular level to a continuum suspension level,
represents the natural approach to the study of a suspension of biological cells. In this
talk, we introduce some of our recent studies on interactions between a pair of red
blood cells and swimming microorganisms, as a two-body interaction is the simplest
many-body interaction. Then, collective motions formed by a group of cells are
discussed. Lastly, we discuss how macroscopic suspension properties are changed by
the microscopic characteristics of the cell suspension. This talk clarifies many
complex behaviors of biological suspensions.
26
Curriculum Vitae
Dr. Chuang, Han-Sheng received his bachelor and master degrees in the Department
of Mechanical Engineering from National Cheng Kung University in 1998 and 2000,
respectively. He joined Industrial Technology Research Institute (ITRI) as a R&D
engineer in 2001. After then, he worked with Professor Steve Wereley for advanced
microfluidics and received his Ph.D. in the School of Mechanical Engineering from
Purdue University in 2010. After graduation, he became a postdoctoral researcher at
University of Pennsylvania and worked with Professor Haim Bau on cell sorting and
Caenorhabditis elegan manipulation. He is currently an Assistant Professor of
Biomedical Engineering at National Cheng Kung University where he has been
working since 2011. In 2005, he was awarded a competitive fellowship from Ministry
of Education, Taiwan. He and his research fellows were the finalists of the prestigious
Burton D. Morgan Business Competition in 2008 and 2009, respectively. In addition,
he is also a cofounder of a US-based technical start-up, Microfluidic Innovations,
founded in 2009. Dr. Chuang has been engaged in optoelectromechanical
microfluidics for more than 7 years. His current research interests focus on
biomicro/nano-fluidics, NEMS/MEMS, and optical diagnostics.
Worm in a Drop (WID)
Lecture Time: 15:15-15:45
Chuang, Han-Sheng
Abstract
Aqueous droplets have been exploited as self-contained and low-cost biochemical
vessels in many ways. With sufficient food, appropriate oxygen content and minimum
evaporation, multi-cellular organisms, such as Caenorhabditis (C.) elegans, can
survive in the life capsule for more than one life cycle. The channel-free confined
system provides an undisturbed environment for tracking a specific worm’s activity in
a long term. A well-maintained droplet can support a worm’s life up to 5 days. Except
for swimming gaits, worms in an aqueous droplet express a regular periods of
behavioral quiescence to those observed on agar. Arranging multiple droplets within
the same field of view enables a massively parallel analysis. A 7 by 5 droplet array
was utilized for a simultaneous measurement. The experimental time required was
thus reduced by 35 times as compared to the conventional method. Wild type (N2)
and mutant (egl-4) worms were measured on the chip. The outcome proves that WID
can provide a high throughput screening as well as a fast route for establishing
behavioral patterns of the worms.
27
Curriculum Vitae
Tetsu TANAKA, Ph.D.
Professor
GRADUATE SCHOOL OF BIOMEDICAL ENGINEERING,
TOHOKU UNIVERSITY
6-6-01 AZA-AOBA, ARAMAKI, AOBA-KU, SENDAI 980-8579, JAPAN
Phone:+81-22-795-6258 / Fax:+81-22-795-6259
E-mail: ttanaka@lbc.mech.tohoku.ac.jp
Tetsu Tanaka received the B.S. and M.S. degrees in electronics engineering and the
Ph.D. degree in machine intelligence and systems engineering from Tohoku
University, Sendai, Japan, in 1987, 1990, and 2003, respectively. In 1990, he joined
Fujitsu Laboratories, Ltd., where he was engaged in the research and development of
the highly-scaled MOS devices including SOI devices. From 1994 to 1995, he was a
Visiting Fellow with University of California, Berkeley. In 2005, he moved to the
Tohoku University as an Associate Professor, and became a Professor of Graduate
School of Biomedical Engineering, Tohoku University in 2008.
He is currently working on the research and development of medical micro/nano
devices and system using nanotechnology and semiconductor process/device/circuit
technologies. His current research topics include:
1. Intelligent Si neural probe and brain-machine interface
2. Fully-implantable retinal prosthesis system
3. Bio/nano technology and novel Bio-FET sensor
4. 3-dimensional integration technology and ultra-small advanced semiconductor
devices.
28
Development of implantable medical micro/nano devices based on
semiconductor technology
Lecture Time: 15:45-16:15
Tetsu Tanaka
Abstract
For analyses of brain functions, there are lots of methods such as PET, fMRI, NIRS,
OT, MEG, EEG, and ECoG. Each recording method has advantages and disadvantages
in relation to resolution, invasiveness, efficiency, and so on. In order to record
neuroral signals and stimulate neural tissues in the brain, intelligent Si neural probe
system has been developed. This neural probe has various kinds of interfaces such as
electrodes, microfluidic outlet, and optical waveguides. Furthermore, LSI chips such
as amplifiers, A/D converters, and multiplexers are also integrated on the Si neural
probe for bio-signal anaylsis. This probe is the promising candidate for versatile tool
of neurophysiology. Novel retinal prosthesis with fully implantable 3-dimensionally
(3-D) stacked retinal prosthesis chip has also been proposed and developed. The
retinal prosthesis chip consists of several LSI chips that are vertically stacked and
electrically connected using 3-D integration technology. In our retinal prosthesis, all
the parts of retinal prosthesis are implanted into an eyeball. By implanting all parts,
blind patient can shift a gaze point by moving the eyeball and use own ocular system
such as a lens and a cornea, which brings high QOL to the blind patients. In the forum,
current research results for both implantable medical micro/nano devices will be
presented.
29
Curriculum Vitae
Jia-Jin Jason Chen
Institute of Biomedical Engineering,
National Cheng Kung University, Tainan 701, Taiwan
E-mail:Jason_chen@jason.bme.ncku.edu.tw
Personal Information
Born: Sept 6th, 1958
Education
B. S., Biomedical Engineering, Chung Yuan Christian University
M. S., Biomedical Engineering, Vanderbilt University, TN, USA
Ph.D., Biomedical Engineering, Vanderbilt University, TN, USA
Professional Experience
Visiting Scientist, U. of Cape Town, South Africa
Visiting Scientist, Neuroscience Division, U. of Alberta, Canada
Honorary Professor, U. of Otago, New Zealand
Director, Institute of Biomedical Engineering, NCKU
Distinguished Professor, Institute of Biomedical Engineering
Professor, Institute of Biomedical Engineering
1980
1987
1990
1991
1998
2004-2005
Since 2009/8
Since 2007
Since 1997
Service and honors
- Executive Editor-in-Chief, Journal of Medical and Biological Engineering
(an SCIE journal)
- Member of NHRI extramural research committee
- Committee member of Department of Industrial Technology for medical device
section
Research Interest
Neural Engineering, Biomedical Engineering, Neural Interface, Neuromuscular
control and functional electrical stimulation, optoelectrical stimulation/sensing
Refereed Papers
1. Tsung-Hsun Hsieh, Jia-Jin J. Chen, Pei-Tzu Chiang, Li-Hsien Chen, Hsiao-Yu
Lee Time-course Gait Analysis of Hemiparkinsonian Rats Following
6-hydroxydopamine Lesion. Behavioural Brain Research, vol. 222, pp. 1–9,
2011.
30
2.
3.
4.
5.
6.
7.
Tien-Chun Tsai, Huan-Zhang Han, Ching-Ching Cheng, Jia-Jin Jason Chen,
“ Modification of Platinum Microelectrode with Molecularly Imprinted
Over-oxidized Polypyrrole for Dopamine Measurement in Rat Striatum,”
Sensors & Actuators: B. Chemical (in press)
Pei-Yi Lin, Sang-I Lin, Jia-Jin Jason Chen, “Functional near infrared
spectroscopy study of age-related difference in cortical activation patterns during
cycling with speed feedback,” IEEE Transactions on Neural Systems &
Rehabilitation Engineering, 2012. (in press)
Pei-Yi Lin, Jia-Jin Jason Chen, Sang-I Lin, “The Cortical Control of Cycling
Exercise in Stroke Patients: an fNIRS study,” Human Brain Mapping. (in pres)
Tsung-Hsun Hsieh, Jian-Yi Tsai, Yi-Ning Wu, Ing-Shiou Hwang, Tai-I Chen
and Jia-Jin J. Chen, “Time-Course Quantification of Spastic Hypertonia
Following Spinal Hemisection in Rats,” Neuroscience, vol. 167, pp. 185–198,
2010.
Shu-Ping Lin, Themis R. Kyriakides, Jia-Jin J. Chen “On-line observation of cell
growth in a three-dimensional matrix on surface-modified microelectrode
arrays,” Biomaterials, 30:3110-3117, 2009. (*Corresponding author)
Chih-Wei Peng, Jia-Jin Jason Chen, Chen-Li Cheng, and Warren M. Grill, “Role
of pudendal afferents in voiding efficiency in the rat,” American Journal of
Physiology-Regulatory Integrative and Comparative Physiology, 294:
R660-R672, 2008.
8. Shu-Ping Lin, Jia-Jin Jason Chen*, Jiunn-Der Liao, Shun-Fen Tzeng,
“Characterization of surface modification on microelectrode arrays for in-vitro
cell culture,” Biomedical Microdevices, vol. 10, no. 1, 99-111, 2008.
9. C.-C. Wang*, T.-J. Lee, U. F. Choi, Y.-T. Hsiao, and J.-J. J. Chen, “A 570-kbps
ASK demodulator without external capacitors for low-frequency wireless
bio-implants,” Microelectronics Journal, vol. 39, no. 1, pp. 130-136, 2008.
10. Chih-Wei Peng, Jia-Jin Jason Chen, Chen-Li Cheng, and Warren M. Grill*,
“Improved bladder emptying in urinary retention by electrical stimulation of
pudendal afferents,” Journal of Neural Engineering, vol. 5, 144-154, 2008
31
Applications of Implantable Biomicrosystems
Lecture Time: 16:15-16:45
Jia-Jin Jason Chen, PhD
Department of Biomedical Engineering, National Cheng Kung University
Abstract
Implantable biomicrosystems have been applied for various neural engineering
applications. In our studies, we have implemented implantable biomicrosystem for
facilitating and monitoring peripheral nerve regeneration as well as for brain neuronal
activities of animal studies.
We implemented an implantable wireless biomicrosystem that delivers electrical
stimulation for promoting nerve regeneration and provides nerve impedance
measurement for assessing nerve regeneration. The implantable device is small
enough for in vivo study and relies on an external module for transmitting both power
and commands via a transcutaneous coupling technique. With the wireless
transmission scheme, the problem of wires causing wound infections during
long-term monitoring is avoided. The integrated wireless biomicrosystem is used for
performing programmable electrical stimulation treatment via a cuff electrode
wrapped around the transected sciatic nerve. The change of impedance during nerve
regeneration is monitored using two- and four-terminal impedance measurement
techniques using the implanted wireless module. For in vivo study, the implanted
module after hermetical packaging was placed in the rat’s abdomen and the cuff
electrode was wrapped around an 8-mm sciatic nerve gap of the rat for 42 days. One
group of animals received monophasic constant current via the cuff electrode and a
second group had no stimulation during 6 weeks. The nerve impedance increased to
above 150% of the initial value in the nerve regeneration groups with and without
stimulation whereas the group with no nerve regeneration increased to only 113% at
day 42. The nerve regeneration group that received electrical stimulation had a higher
myelinated fiber density (20686 ± 1489 fiber/mm2) than that of no stimulation group
(11417 ± 2361 fiber/mm2). The developed implantable biomicrosystem is proven to
be a useful experimental tool for long-term stimulation in aiding nerve fiber growth as
well as impedance assessment for understanding the time-course changes of nerve
regeneration.
For Brain activity, we used flexible material like SU-8 material as probe backbone
which could provide potential application for neural implant. We design, fabricate and
test a flexible SU-8 based neuroprobe for brain neuronal activity. Mechanical tests
were performed by single-axis tensile tester using brain phantom and rat brain,
respectively. Our results indicated that the SU-8 neuroprobe has enough mechanical
strength for inserting as brain implant and also has the mechanical flexibility after
long-term implantation. The biocompatibility tests of in vitro cytotoxicity and in vivo
immunohistological staining showed that our SU-8 neuroprobe represented
non-toxicity in vitro and less acute surgical damage and chronic inflammation after
implantation in vivo. The electrophysiological recording functionality was proven by
acute recording of rat under anesthesia state. With the improvement in probe
flexibility, it could be implanted with long-term stability and provide as candidate for
future-generation of neuroprobe.
32
MEMO
National Cheng Kung University
Taiwan-Japan Joint Symposium on
Medical Device Innovation
Program
09:30-10:00
10:00-10:30
台日創新醫療器材國際研討會
Registration
Opening Ceremony
Podium Session
10:30 Su, Fong-Chin, NCKU
Medical Device Innovation at NCKU.
10:30-12:30
11:00 Yamaguchi, Takami, Tohoku University
Education and Studies in the Graduate School
of Biomedical Engineering of Tohoku University.
11:30 Wang, Shyh-Hau, NCKU
High Frequency Ultrasound Technologies for
Characterizing Biological Tissues and Materials.
12:00 Yoshifumi, Saijo, Tohoku University
Advanced Biomedical Ultrasound Technologies
to Explore Cardiovascular Dynamics and
Biomechanics.
12:30-13:30
Lunch
Podium Session
13:30-15:00
13:30 Haga, Yoichi, Tohoku University
Medical Devices for Minimally Invasive Diagnosis
and Therapy Using Micro/nano Fabrication
Technology.
14:00 Chen, Yih-Fan, NCKU
Nanomanipulation Using Near Field Photonics.
14:30 Ishikawa, Takuji, Tohoku University
Transport Phenomena in Suspensions of
Biological Cells.
15:00-15:15
Tea Break
15:15 Chuang, Han-Sheng, NCKU
"Worm in a drop”
15:15-16:45
15:45 Tanaka, Tetsu, Tohoku University
Development of implantable medical micro/nano
devices based on semiconductor technology.
16:15 Chen, Jia-Jin Jason, NCKU
Applications of Implantable Biomicrosystems.
16:45-17:20
Discussion
17:20-17:30
Closing Ceremony