No. 161 August 2013 Herbs to Relieve Pain & Relax California Poppy California Poppy (Eschscholzia californica) is the official state flower of California. The plant, which grows to about 60 cm, has feathery foliage and velvety, golden-orange flower petals. It is a member of the Papaveraceae. Much of the original information about the medicinal use of California Poppy comes from people living in the northwestern coastal areas of the United States. Native Americans used Californian Poppy leaf for toothache. The leaves were also eaten as greens.1 Early settlers used California Poppy to relieve colic and to promote sleep, particularly in children with whooping cough. It was prescribed for adults as an “antineuralgicum” (relieving neuralgia) and to relieve severe headache.1,2 The Eclectic physicians regarded California Poppy as a “valuable” analgesic and mild sedative for “quieting pain and producing calm sleep”.3 It was applied for these activities in patients when the use of a strong narcotic was inadvisable,2 and “without the dangers attending opiates”.3 Regular and prolonged use was reported not to be addictive or to impair mental functioning.2 Contemporary Western herbalists have also used California Poppy for nervous bowel, migraine, nervous and emotional stress.4 Jamaica Dogwood Jamaica Dogwood (Piscidia piscipula, synonym Piscidia erythrina) is a member of the Leguminosae. The mediumsized, deciduous, tropical tree is indigenous to the West Indies, Florida, Mexico and Central America. The root bark of Jamaica Dogwood has been used traditionally in Western herbal medicine as an analgesic, sedative and antispasmodic.3,5,6 Traditional indications include:3,7-9 insomnia, particularly when due to neuralgia or nervous tension, or when prolonged; restlessness; Not for Public Distribution. For Education of Health Care Professionals Only. neuralgia, particularly sciatica; neuralgia associated with the kidneys, abdomen, ovaries, trigeminal nerve and eyes; migraine; dysmenorrhoea; mild relief of abdominal, renal or gallbladder pain; muscle spasm, rheumatism, toothache, earache, painful affections of the eye, pain associated with fracture; whooping cough, to relieve spasm of asthma. The Eclectic physicians also noted that Jamaica Dogwood had milder analgesic activity than opium, but without the unpleasant side effects.10 It is possible that stem bark was also used medicinally by the Eclectic physicians. In 1881, it is recorded that “the bark of the tree has lately been introduced as a ... hypnotic” and claimed to be efficacious by some.11 In 1948, it was noted that commercial products in the United States consisted of stem bark.12 The bark of the root and stem of Jamaica Dogwood was used as an analgesic by the inhabitants of the Antilles (Caribbean).13 The bark (unspecified) has been used in Mexico and Central America for insomnia,14 and in Jamaica for relief of backache and other pains.15 Corydalis The tuber of a number of species of Corydalis (C. ambigua, C. yanhusuo and C. turtschaninovii) has been used in traditional Chinese medicine (TCM) and is known as Yanhusuo. The plant is a member of the Papaveraceae. Yanhusuo is used to relieve pain and to promote circulation.16 In TCM the basis of pain is an incompatibility between blood and qi, thus “stagnation causes pain ... opening the stagnancy will remove that pain”.17 Corydalis is used to treat pain from a variety of causes in all parts of the body.18 Traditional indications include:16-21 neuralgia, dysmenorrhoea; chest pain, epigastric pain, abdominal pain, gastrointestinal spasm; 1 pain in the extremities, joint pain, lumbago; injuries due to impact, fractures, bruises, sprains; amenorrhoea, blood stasis after childbirth, postpartum abdominal pain. Yanhusuo is frequently used by TCM practitioners to improve the efficacy of chemotherapy, and prescribed for pain relief to patients with terminal cancer.22,23 Studies of Other Related Herbs & Combinations A preparation containing Californian Poppy and the tuber of Corydalis cava has been clinically evaluated in Germany. The result of two clinical trials showed that disturbed sleeping behaviour could be normalised by treatment with the combination.24 Details of the preparation, including dosage, are not known except that it contained 80% Californian Poppy and 20% Corydalis cava. In an uncontrolled trial, quality of sleep improved in 20 of 22 patients with mild sleep disorders who were treated for 4 weeks25 with a combination of Californian Poppy (60%), Corydalis cava tuber (5%), Leonurus cardiaca herb (17.5%) and Passiflora incarnata herb (17.5%).26 A combination containing Californian Poppy, Crataegus oxyacantha flowering head, and magnesium was more effective than placebo in reducing mild to moderate anxiety.27 Eclectic Medical Publications, Portland, 1983. 4 Bartram T. Encyclopedia of Herbal Medicine, 1st Edn. Grace Publishers, Dorset, 1995. 5 British Herbal Medicine Association. British Herbal Compendium. BHMA, Bournemouth, 1992. 6 Pharmaceutical Society of Great Britain. British Pharmaceutical Codex 1934. The Pharmaceutical Press, London, 1941. 7 British Herbal Medicine Association’s Scientific Committee. British Herbal Pharmacopoeia. BHMA, Bournemouth, 1983. 8 Ellingwood F, Lloyd JU. American Materia Medica, Therapeutics and Pharmacognosy. 11th Edn. Naturopathic Medical Series: Botanical Vol 2. First published 1898, reprinted Eclectic Medical Publications, Portland, 1983. 9 Wren RC. Potter’s New Cyclopaedia of Botanical Drugs and Preparations. First published 1907, reprinted C.W. Daniel Company Limited, Essex, 1989. 10 Culbreth DMR. A Manual of Materia Medica and Pharmacology. Naturopathic Medical Series: Botanical Vol 3. First published 1922, reprinted Eclectic Medical Publications, Portland, 1983. 11 Proceedings of the American Pharmaceutical Association at the Twenty-ninth Annual Meeting. Held in Kansas City, Mo., August 1881. Sherman & Co, Philadelphia, 1882. 12 Costello CH, Butler CL. J Am Pharm Assoc 1948; 37: 89 13 Auxence EG. Econ Bot 1953; 7: 270 14 García-Alvarado JS et al. J Herbs Spices Med Plants 2001; 8: 37 15 Asprey GF, Thornton P. West Indian Med J 1955; 4: 145 16 Pharmacopoeia Commission of the People’s Republic of China. Pharmacopoeia of the People’s Republic of China, English Edn. Chemical Industry Press, Beijing, 1997. 17 Huang KC. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, 1993. 18 Chen JK et al. Chinese Medical Herbology and Pharmacology. Art of Medicine Press, California, 2004. 19 Chang HM, But PP. Pharmacology and Applications of Chinese Materia Medica. World Scientific, Singapore, 1987. 20 Bensky D, Gamble A. Chinese Herbal Medicine Materia Medica. Eastland Press, Seattle, 1986. 21 Zheng G, Zhang C. Concise Chinese Materia Medica. The Series of Traditional Chinese Medicine for Foreign Readers. Shandong Science and Technology Press, Jinan, 1997. 22 Lei Y et al. Food Chem 2013; 136: 1117 23 Gao JL et al. Oncol Rep 2008; 20: 819 24 Schäfer HL et al. Arzneim Forsch 1995; 45: 124 25 Becker W. Therapiewoche 1986; 36: 3830 26 Weischer ML, Okpanyi SN. Z Phytother 1994; 15: 257 27 Hanus M et al. Curr Med Res Opin 2004; 20: 63 Author: Michelle Morgan © Copyright 2013 MediHerb. Supportive Formulation These herbs would complement each other in a very potent formulation with the following actions: analgesic, sedative, antispasmodic. Indications Nerve-related pain especially neuralgia, headache, sciatica, shingles. Musculoskeletal and arthritic pain, including back pain, arthritis, muscle cramps. Dysmenorrhoea. Insomnia, restlessness, nervous tension. Cautions and Contraindications Caution is advised for women wishing to conceive. Contraindicated in pregnancy, bradycardia and cardiac insufficiency. Not recommended during lactation. REFERENCES 1 Moerman DE. Native American Ethnobotany. Timber Press, Portland, 1998. 2 Cheney RH. Quart J Crude Drugs 1963; 3: 413 3 Felter HW, Lloyd JU. King’s American Dispensatory, 18th Edn, 3rd revision, 1905, reprinted Not for Public Distribution. For Education of Health Care Professionals Only. 2