Step Therapy Criteria CW 2016 Last Updated: 2/17/2016 5-HT3 ANTAGONIST ANTIEMETICS MEDICATION(S) SUBJECT TO STEP THERAPY ANZEMET, EMEND 125 MG CAPSULE, EMEND 40 MG CAPSULE, EMEND 80 MG CAPSULE, EMEND TRIPACK, GRANISETRON HCL, ONDANSETRON 4 MG/2 ML AMPULE, ONDANSETRON 4 MG/5 ML SOLUTION, ONDANSETRON HCL 24 MG TABLET, ONDANSETRON HCL 4 MG/2 ML VIAL CRITERIA Beneficiary must try ondansetron 4mg or 8mg tablets or ondansetron 4mg or 8mg ODTs for seven days as step one before being able to receive ondansetron 24mg, ondansetron injectable solution, ondansetron oral solution, or any of the forms of granisetron for thirty days as step two before being able to receive dolasetron or any of the forms of aprepitant as step three. PAGE 1 LAST UPDATED 02/2016 ACNE AGENTS MEDICATION(S) SUBJECT TO STEP THERAPY ADAPALENE 0.1% GEL, ERYTHROMYCIN-BENZOYL PEROXIDE, METRONIDAZOLE TOPICAL 0.75% GL, TAZORAC, TRETINOIN 0.01% GEL, TRETINOIN 0.025% CREAM, TRETINOIN 0.025% GEL, TRETINOIN 0.05% CREAM, TRETINOIN 0.1% CREAM CRITERIA Beneficiary must try sulfacetamide suspension, erythromycin gel or solution, or clindamyacin lotion or solution for thirty days as step one before receiving metronidazole gel, benzoyl peroxide/erythromycin gel, tretinoin cream, or tretinoin gel for thirty days as step two and trial two step two therapies before receiving adapalene 1% gel, tazarotene cream, or tazarotene gel as step three. Beneficiaries requesting tazarotene for the indication of psoriasis should refer to the psoriasis agents group for relevant step therapy criteria. Beneficiaries requesting metronidazole topical gel for rosacea will be eligible for an exception to the step one requirement. PAGE 2 LAST UPDATED 02/2016 ALPHA- ADRENERGIC AGONISTS MEDICATION(S) SUBJECT TO STEP THERAPY DEXTROAMPHETAMINE-AMPHET ER CRITERIA Beneficiary must try immediate release amphetamine/dextroamphetamine mixed salts for sixty days as step one before receiving extended release amphetamine/dextroamphetamine mixed salts as step two. PAGE 3 LAST UPDATED 02/2016 ANGIOTENSIN RECEPTOR ANTAGONISTS MEDICATION(S) SUBJECT TO STEP THERAPY TEKTURNA, TELMISARTAN, TELMISARTAN-HYDROCHLOROTHIAZID, VALSARTAN, VALSARTAN-HYDROCHLOROTHIAZIDE CRITERIA Beneficiary must try losartan, losartan/hydrochlorothiazide, irbesartan, irbesartan/hydrochlorothiazide, candesartan, or candesartan/hydrochlorothiazide as step one for thirty days before being able to receive telmisartan, telmisartan/hydrochlorothiazide, valsartan, or valsartan/hydrochlorothiazide for thirty days as step two before receiving sacubitril/valsartan or aliskiren (Tekturna) as step three. Beneficiaries requesting valsartan or valsartan/hydrochlorothiazide for an indication for reduction of cardiovascular mortality with left ventricular failure or left ventricular dysfunction following myocardial infarction will be eligible for an exception to the step one requirement. Beneficiaries requesting telmisartan or telmisartan/hydrochlorothiazide for an indication of cardiovascular event risk reduction will be eligible for an exception to the step one requirement. PAGE 4 LAST UPDATED 02/2016 ANGIOTENSIN RECEPTOR ANTAGONISTS II MEDICATION(S) SUBJECT TO STEP THERAPY ENTRESTO, TEKTURNA, TELMISARTAN, TELMISARTAN-HYDROCHLOROTHIAZID, VALSARTAN 160 MG TABLET, VALSARTAN 320 MG TABLET, VALSARTAN 80 MG TABLET, VALSARTANHYDROCHLOROTHIAZIDE CRITERIA Beneficiary must try losartan, losartan/hydrochlorothiazide, irbesartan, irbesartan/hydrochlorothiazide, candesartan, or candesartan/hydrochlorothiazide as step one for thirty days before being able to receive telmisartan, telmisartan/hydrochlorothiazide, valsartan, or valsartan/hydrochlorothiazide for thirty days as step two before receiving sacubitril/valsartan or aliskiren (Tekturna) as step three. Beneficiaries requesting valsartan or valsartan/hydrochlorothiazide for an indication for reduction of cardiovascular mortality with left ventricular failure or left ventricular dysfunction following myocardial infarction will be eligible for an exception to the step one requirement. Beneficiaries requesting telmisartan or telmisartan/hydrochlorothiazide for an indication of cardiovascular event risk reduction will be eligible for an exception to the step one requirement. PAGE 5 LAST UPDATED 02/2016 ANTI-PSYCHOTIC MEDICATION(S) SUBJECT TO STEP THERAPY FANAPT, LATUDA, ZIPRASIDONE HCL CRITERIA Beneficiary must try risperidone or quetiapine for thirty days as step one before receiving oral ziprasidone or injectable ziprasidone for thirty days as step two before being able to receive iloperidone (Fanapt) or lurasidone (Latuda) as step three. Any beneficiary currently taking a step two or step three medication will not be subject to the step therapy restrictions. Beneficiaries requesting injectable ziprasidone for acute agitation in schizophrenia will be eligible for an exception to the step one criteria. PAGE 6 LAST UPDATED 02/2016 ANTICHOLINERGIC BRONCHODILATORS MEDICATION(S) SUBJECT TO STEP THERAPY SPIRIVA, SPIRIVA RESPIMAT 1.25 MCG INH CRITERIA Beneficiary must try ipratropium bromide or albuterol/ipratropium for thirty days as step one before being able to receive tiotropium bromide as step two. PAGE 7 LAST UPDATED 02/2016 ANTICHOLINERGIC BRONCHODILATORS II MEDICATION(S) SUBJECT TO STEP THERAPY TUDORZA PRESSAIR CRITERIA Beneficiary must try ipratropium bromide or albuterol/ipratropium for thirty days as step one before being able to receive aclidinium bromide as step two. PAGE 8 LAST UPDATED 02/2016 ANTICOAGULATION MEDICATION(S) SUBJECT TO STEP THERAPY PRADAXA, XARELTO CRITERIA Beneficiary must try warfarin for thirty days as step one before being able to receive dabigatran or rivaroxaban as step two. PAGE 9 LAST UPDATED 02/2016 ANTIHISTAMINES MEDICATION(S) SUBJECT TO STEP THERAPY AZELASTINE 0.1% (137 MCG) SPRY, AZELASTINE 0.15% NASAL SPRAY, OLOPATADINE 665 MCG NASAL SPRY CRITERIA Beneficiaries must trial OTC loratadine, OTC fexofenadine, or OTC cetirizine for thirty days before receiving azelastine nasal or olopatadine nasal as step two. Beneficiaries requesting azelastine nasal for vasomotor rhinitis will be eligible for an exception to this step therapy. PAGE 10 LAST UPDATED 02/2016 ANTILEUKOTRIENES MEDICATION(S) SUBJECT TO STEP THERAPY ZYFLO, ZYFLO CR CRITERIA Beneficiary must try montelukast or zafirlukast as step one for thirty days before receiving zileuton as step two. PAGE 11 LAST UPDATED 02/2016 APOMORPHINE MEDICATION(S) SUBJECT TO STEP THERAPY APOKYN CRITERIA Beneficiary must try carbidopa/levodopa or amantadine capsules as step one for thirty days before receiving apomorphine (Apokyn) as step two. PAGE 12 LAST UPDATED 02/2016 ATYPICAL ANTIPSYCHOTICS MEDICATION(S) SUBJECT TO STEP THERAPY REXULTI CRITERIA Beneficiary must try and fail aripiprazole tablets for sixty days as step one before receiving brexpiprazole as step two. This applies to new starts only. PAGE 13 LAST UPDATED 02/2016 BETA BLOCKERS - EXTENDED RELEASE MEDICATION(S) SUBJECT TO STEP THERAPY COREG CR CRITERIA Beneficiary must try metoprolol ER or propranolol ER for thirty days as step one before receiving carvedilol CR as step two. Beneficiaries requesting carvedilol ER for left ventricular dysfunction following myocardial infarction will be eligible for an exception to the step one criteria. PAGE 14 LAST UPDATED 02/2016 CARDIOVASCULAR MEDICATION(S) SUBJECT TO STEP THERAPY REPATHA SURECLICK, REPATHA SYRINGE CRITERIA Beneficiary must try simvastatin/ezetimibe and atorvastatin for sixty days as step one and try and fail both step one medications before being able to receive evolocumab as step two. Patients with a contraindication to ezetimibe and statins will be eligible for an exception for this step criteria. PAGE 15 LAST UPDATED 02/2016 CLOSTRIDIUM DIFFICILE TREATMENT MEDICATION(S) SUBJECT TO STEP THERAPY DIFICID CRITERIA Beneficiary must try oral vancomycin for seven days as step one before receiving fidaxomicin as step two. PAGE 16 LAST UPDATED 02/2016 DESVENLAFAXINE MEDICATION(S) SUBJECT TO STEP THERAPY DESVENLAFAXINE ER CRITERIA Beneficiary must try venlafaxine for thirty days as step one before receiving desvenlafaxine as step two. Any beneficiary currently taking desvenlafaxine will not be subject to the step therapy restrictions. PAGE 17 LAST UPDATED 02/2016 DIABETES TREATMENT MEDICATION(S) SUBJECT TO STEP THERAPY AVANDAMET 2 MG-1,000 MG TAB, AVANDIA, BYETTA, FARXIGA, INVOKAMET, INVOKANA, JANUMET, JANUVIA, PIOGLITAZONE HCL, PIOGLITAZONE-METFORMIN, SYMLINPEN 120, SYMLINPEN 60, VICTOZA 2-PAK, VICTOZA 3-PAK, WELCHOL 625 MG TABLET CRITERIA Beneficiary must trial metformin, metformin ER, metformin/glipizide, or glipizide as step one before receiving sitagliptin, sitagliptin/metformin, rosiglitazone, rosiglitazone/metformin, pramlintide, pioglitizone, pioglitazone/metformin, liraglutide, exenatide, colesevelam, dapagliflozin propanediol, canaglifloin, or canagliflozin/metformin as step two. Beneficiaries requesting colesevelam for the indication of primary hyperlipidemia will be eligible for an exception to the step one criteria. PAGE 18 LAST UPDATED 02/2016 DRONEDARONE (MULTAQ) MEDICATION(S) SUBJECT TO STEP THERAPY MULTAQ CRITERIA Beneficiary must try diltiazem, flecanide, propafenone, or quinidine for 30 days as step one before receiving dronedarone as step two. PAGE 19 LAST UPDATED 02/2016 ERGOTAMINE MEDICATION(S) SUBJECT TO STEP THERAPY DIHYDROERGOTAMINE 1 MG/ML AM, DIHYDROERGOTAMINE 1 MG/ML VL CRITERIA Beneficiary must trial ergotamine or caffeine/ergotamine for sixty days as step one before receiving dihydroergotamine as step two. PAGE 20 LAST UPDATED 02/2016 ESCITALOPRAM MEDICATION(S) SUBJECT TO STEP THERAPY ESCITALOPRAM 10 MG TABLET, ESCITALOPRAM 20 MG TABLET, ESCITALOPRAM 5 MG TABLET CRITERIA Beneficiary must try citalopram for thirty days as step one before receiving escitalopram as step two. Any beneficiary currently taking a step two medication will not be subject to the step therapy restrictions. PAGE 21 LAST UPDATED 02/2016 FIBRIC ACID DYSLIPIDEMICS MEDICATION(S) SUBJECT TO STEP THERAPY FENOFIBRATE, FENOFIBRIC ACID 105 MG TABLET, FENOPROFEN CALCIUM 400 MG CAP, FIBRICOR CRITERIA Beneficiary must try gemfibrozil for sixty days as step one before receiving fenofibrate as step two. PAGE 22 LAST UPDATED 02/2016 HEPATIC ENCEPHALOPATHY MEDICATION(S) SUBJECT TO STEP THERAPY XIFAXAN CRITERIA Beneficiary must try lactulose for fourteen days as step one before being eligible to receive rifaximin (Xifaxan) as step two for hepatic encephalopathy. Beneficiaries requiring rifaximin for traveler's diarrhea or irritable bowel syndrome with diarrhea will be eligible for an exception to the step one criteria. PAGE 23 LAST UPDATED 02/2016 INJECTABLE ANTICOAGULANTS MEDICATION(S) SUBJECT TO STEP THERAPY FONDAPARINUX SODIUM, FRAGMIN CRITERIA Beneficiary must try enoxaparin for 14 days as step one before receiving dalteparin or fondaparinux as step two. PAGE 24 LAST UPDATED 02/2016 IRON CHELATION MEDICATION(S) SUBJECT TO STEP THERAPY FERRIPROX CRITERIA Beneficiary must try deferasirox for thirty days as step one before receiving deferiprone as step two. PAGE 25 LAST UPDATED 02/2016 IV PROTON PUMP INHIBITORS MEDICATION(S) SUBJECT TO STEP THERAPY ESOMEPRAZOLE SODIUM CRITERIA Beneficiary must try pantoprazole IV for 30 days as step one before receiving esomeprazole IV as step two. PAGE 26 LAST UPDATED 02/2016 MAJOR DEPRESSIVE DISORDER MEDICATION(S) SUBJECT TO STEP THERAPY BRINTELLIX, FETZIMA CRITERIA Beneficiary must try venlafaxine, citalopram, or sertraline for thirty days as step one before receiving levomilnacipran or vortioxetine as step two. Any beneficiary currently taking a step two or step three medication will not be subject to the step therapy restrictions. PAGE 27 LAST UPDATED 02/2016 MEGLITINIDE MEDICATION(S) SUBJECT TO STEP THERAPY PRANDIMET, REPAGLINIDE, REPAGLINIDE-METFORMIN HCL CRITERIA Beneficiary must try nataglinide for thirty days as step one before receiving repaglinide or repaglinide/metformin as step two. PAGE 28 LAST UPDATED 02/2016 MESALAMINE MEDICATION(S) SUBJECT TO STEP THERAPY CANASA, LIALDA CRITERIA Beneficiary must try mesalamine (Asacol), mesalamine (Pentasa), mesalamine (Delzicol), or mesalamine (Apriso) for thirty days as step one. Beneficiary must trial two (2) step one mesalamine formulations before being able to receive mesalamine (Canasa) or mesalamine (Lialda) as step two. PAGE 29 LAST UPDATED 02/2016 MIGRAINE ABORTIVE AGENTS (5) MEDICATION(S) SUBJECT TO STEP THERAPY SUMATRIPTAN 4 MG/0.5 ML CART, SUMATRIPTAN 4 MG/0.5 ML INJECT, SUMATRIPTAN 6 MG/0.5 ML REFILL, SUMATRIPTAN 6 MG/0.5 ML VIAL, ZOLMITRIPTAN 2.5 MG TABLET, ZOLMITRIPTAN 5 MG TABLET, ZOLMITRIPTAN ODT, ZOMIG 2.5 MG NASAL SPRAY, ZOMIG 5 MG NASAL SPRAY CRITERIA Beneficiary must try sumatriptan tablets or naratriptan tablets or rizatriptan tablets for thirty days as step one and trial two step one therapies before being able to receive zolmitriptan tablets, zolmitriptan orally disintegrating tablets, zolmitriptan nasal spray, or sumatriptan injection as step two. Beneficiaries requesting injectable sumatriptan for the indication of acute treatment of cluster headaches will be eligible for an exception to the step one criteria. PAGE 30 LAST UPDATED 02/2016 MONOAMINE OXIDASE B (MOA-B) INHIBITORS MEDICATION(S) SUBJECT TO STEP THERAPY AZILECT CRITERIA Beneficiary must try selegiline as step one before receiving rasagiline mesylate as step two. PAGE 31 LAST UPDATED 02/2016 MUCOLYTICS MEDICATION(S) SUBJECT TO STEP THERAPY PULMOZYME CRITERIA Beneficiary must try acetylcysteine for thirty days as step one before being able to receive dornase alfa as step two. PAGE 32 LAST UPDATED 02/2016 NASAL STEROIDS MEDICATION(S) SUBJECT TO STEP THERAPY FLUTICASONE PROP 50 MCG SPRAY, TRIAMCINOLONE 55 MCG NASAL SPR CRITERIA OTCs: "NASACORT ALLERGY 24HR", "FLONASE ALLERGY RELIEF". Beneficiary must trial OTC nasal triamcinolone or OTC nasal fluticasone before receiving legend nasal triamcinolone or legend nasal fluticasone. PAGE 33 LAST UPDATED 02/2016 NON-OPIOID ANALGESICS MEDICATION(S) SUBJECT TO STEP THERAPY CELECOXIB 100 MG CAPSULE, CELECOXIB 200 MG CAPSULE, CELECOXIB 400 MG CAPSULE, CELECOXIB 50 MG CAPSULE CRITERIA Beneficiary must try oxaprozin, ibuprofen, or naproxen on a scheduled basis for thirty days as step one and try two step one therapies before receiving celecoxib as step two. Beneficiaries requesting celecoxib for ankylosing spondylitis will be eligible for an exception to the step one criteria. PAGE 34 LAST UPDATED 02/2016 NOREPINEPHRINE REUPTAKE INHIBITORS MEDICATION(S) SUBJECT TO STEP THERAPY STRATTERA CRITERIA Beneficiary must try methylphenidate for thirty days as step one before receiving atomoxetine as step two. PAGE 35 LAST UPDATED 02/2016 OPIOID ANALGESICS MEDICATION(S) SUBJECT TO STEP THERAPY FENTANYL 100 MCG/HR PATCH, FENTANYL 12 MCG/HR PATCH, FENTANYL 25 MCG/HR PATCH, FENTANYL 50 MCG/HR PATCH, FENTANYL 75 MCG/HR PATCH, FENTANYL CIT OTFC 1,200 MCG, FENTANYL CIT OTFC 1,600 MCG, FENTANYL CITRATE OTFC 200 MCG, FENTANYL CITRATE OTFC 400 MCG, FENTANYL CITRATE OTFC 600 MCG, FENTANYL CITRATE OTFC 800 MCG, OXYCODONE HCL ER CRITERIA Beneficiary must try scheduled doses of methadone or extended release morphine for thirty days as step one before receiving scheduled doses of oxycodone SR for thirty days as step two before receiving fentanyl patches or lozenges as step three. Beneficiaries receiving fentanyl lozenges for breakthrough cancer pain will be eligible for an exception to this Step Therapy. PAGE 36 LAST UPDATED 02/2016 OPIOID-INDUCED CONSTIPATION MEDICATION(S) SUBJECT TO STEP THERAPY RELISTOR 12 MG/0.6 ML KIT, RELISTOR 12 MG/0.6 ML VIAL, RELISTOR 8 MG/0.4 ML SYRINGE CRITERIA Beneficiary must trial naloxegol for thirty days as step one before receiving methylnaltrexone as step two. PAGE 37 LAST UPDATED 02/2016 OSTEOPOROSIS MEDICATION(S) SUBJECT TO STEP THERAPY FORTEO, IBANDRONATE 3 MG/3 ML VIAL, IBANDRONATE SODIUM 150 MG TAB, PROLIA, ZOLEDRONIC ACID 5 MG/100 ML CRITERIA Beneficiary must try alendronate or etidronate for six months as step one before receiving ibandronate, zoledronic acid (Reclast formulation only) or denosumab (Prolia) for six months as step two before receiving teriparatide (Forteo) as step three. Beneficiaries receiving denosumab (Prolia) for cancer treatment associated bone loss or receiving teriparatide (Forteo) for glucocorticoid-induced osteoporosis will be eligible for an exception to this step therapy. PAGE 38 LAST UPDATED 02/2016 OXCARBAZEPINE MEDICATION(S) SUBJECT TO STEP THERAPY OXTELLAR XR CRITERIA Beneficiary must try immediate release oxcarbazepine for thirty days as step one before receiving extended release oxcarbazepine as step two. Beneficiaries currently receiving a step two product will be eligible for an exception to this step therapy. PAGE 39 LAST UPDATED 02/2016 PALIPERIDONE MEDICATION(S) SUBJECT TO STEP THERAPY GEODON 20 MG/ML VIAL, INVEGA, INVEGA SUSTENNA, PALIPERIDONE ER, ZIPRASIDONE HCL CRITERIA Beneficiary must try risperidone or quetiapine for thirty days as step one before receiving oral or injectable ziprasidone for thirty days as step two before being able to receive paliperidone (Invega) as step three. Any beneficiary currently taking a step two or step three medication will not be subject to the step therapy restrictions. Beneficiaries requesting injectable ziprasidone for acute agitation in schizophrenia will be eligible for an exception to the step one criteria. Any beneficiary with a diagnosis of schizoaffective disorder will be eligible for an exception to this step. PAGE 40 LAST UPDATED 02/2016 PROTON PUMP INHIBITORS MEDICATION(S) SUBJECT TO STEP THERAPY LANSOPRAZOLE DR 15 MG CAPSULE, LANSOPRAZOLE DR 30 MG CAPSULE, OMEPRAZOLE DR 40 MG CAPSULE, PANTOPRAZOLE SOD DR 20 MG TAB, PANTOPRAZOLE SOD DR 40 MG TAB CRITERIA Beneficiary must try OTC omeprazole, OTC lansoprazole, or OTC esomeprazole, legend omeprazole 10mg, or legend omeprazole 20mg for thirty days as step one before receiving legend omeprazole 40mg or legend pantoprazole for thirty days as step two before receiving legend lansoprazole as step three. Beneficiaries with an indication for NSAID-induced gastric ulcer prophylaxis or treatment will be eligible for an exception to this Step Therapy requirement. PAGE 41 LAST UPDATED 02/2016 PSORIASIS AGENTS MEDICATION(S) SUBJECT TO STEP THERAPY ACITRETIN CRITERIA Beneficiary must trial topical fluocinonide cream, fluocinonide solution, fluocinonide gel, triamcinolone ointment, or sulfacetamide solution for thirty days as step one before receiving a topical tazarotene for thirty days as step two before receiving acitretin (Soriatane) as step three. Beneficiaries receiving tazarotene for acne should refer to the "acne agents" group for relevant step therapy criteria. PAGE 42 LAST UPDATED 02/2016 PULMONARY ANTIHYPERTENSIVES MEDICATION(S) SUBJECT TO STEP THERAPY ADEMPAS, LETAIRIS, OPSUMIT, REMODULIN, TRACLEER CRITERIA Beneficiary must try sildenafil or tadalafil for sixty days as step one before receiving bosentan, treprostinil, or ambrisentan for thirty days as step two before receiving riociguat or macitentan as step three. Beneficiaries requesting riociguat for Chronic Thromboembolic Pulmonary Hypertension will be eligible for an exception to this step therapy. PAGE 43 LAST UPDATED 02/2016 ROTIGOTINE MEDICATION(S) SUBJECT TO STEP THERAPY NEUPRO CRITERIA Beneficiary must trial gabapentin enacarbil (if for restless legs) or carbidopa-levodopa-entacapone (if for Parkinsons Disease) as step one for thirty days before receiving rotigotine transdermal as step two. PAGE 44 LAST UPDATED 02/2016 SMOKING CESSATION MEDICATION(S) SUBJECT TO STEP THERAPY NICOTROL CRITERIA Beneficiary must trial nasal nicotine for at least thirty days as step one before receiving nicotine inhalers as step two. PAGE 45 LAST UPDATED 02/2016 SYMPATHOMIMETIC BRONCHODILATORS MEDICATION(S) SUBJECT TO STEP THERAPY PROAIR HFA CRITERIA Beneficiary must first try Ventolin HFA for thirty days as step one receiving Proair as step two. PAGE 46 LAST UPDATED 02/2016 TOPICAL DICLOFENAC MEDICATION(S) SUBJECT TO STEP THERAPY VOLTAREN CRITERIA Beneficiary must try scheduled doses of ketoprofen or naproxen for thirty days as step one and trial two step one products before being able to receive topical diclofenac as step two. PAGE 47 LAST UPDATED 02/2016 TOPIRAMATE MEDICATION(S) SUBJECT TO STEP THERAPY QUDEXY XR, TOPIRAMATE ER, TROKENDI XR CRITERIA Beneficiary must try immediate release topiramate for thirty days as step one before receiving extended release topiramate as step two. PAGE 48 LAST UPDATED 02/2016 TRAMADOL MEDICATION(S) SUBJECT TO STEP THERAPY TRAMADOL ER 100 MG TABLET, TRAMADOL ER 200 MG TABLET, TRAMADOL ER 300 MG TABLET, TRAMADOL HCL ER 100 MG TABLET, TRAMADOL HCL ER 200 MG TABLET, TRAMADOL HCL ER 300 MG TABLET CRITERIA Beneficiary must try tramadol or acetaminophen/tramadol for thirty days as step one before receiving tramadol ER. PAGE 49 LAST UPDATED 02/2016 TRICYCLICS MEDICATION(S) SUBJECT TO STEP THERAPY CLOMIPRAMINE 25 MG CAPSULE, CLOMIPRAMINE 50 MG CAPSULE, CLOMIPRAMINE 75 MG CAPSULE, IMIPRAMINE HCL 10 MG TABLET, IMIPRAMINE HCL 25 MG TABLET, IMIPRAMINE HCL 50 MG TABLET, SURMONTIL, TRIMIPRAMINE MALEATE CRITERIA Beneficiary must try amitriptyline, nortriptyline, or desipramine as step one for thirty days and try two step one therapies before receiving trimipramine, imipramine, or clomipramine as step two. Any beneficiary currently taking trimipramine imipramine, or clomipramine will not be subject to this step therapy. Beneficiaries requesting clomipramine for an indication of obsessive compulsive disorder will be eligible for an exception to these Step Therapy requirements. PAGE 50 LAST UPDATED 02/2016 URINARY ANTISPASMODICS MEDICATION(S) SUBJECT TO STEP THERAPY ENABLEX, OXYTROL, TOLTERODINE TARTRATE, TOLTERODINE TARTRATE ER, TOVIAZ, TROSPIUM CHLORIDE, TROSPIUM CHLORIDE ER, VESICARE CRITERIA Beneficiary must try oxybutynin or oxybutynin ER for thirty days as step one before receiving tolterodine, tolterodine ER, or trospium IR for thirty days as step two before receiving darifenacin, solifenacin, trospium ER, fesoterodine, or oxybutynin patches (Oxytrol) as step three. PAGE 51 LAST UPDATED 02/2016