Toad + Stool Severed Corpus Callosum • “Bell + Music” example – “Bell” registers in Joe’s right hemisphere • Joe then points to bell picture with his right arm • There is ipsilateral control of gross arm movements – His leD brain sees his arm poinEng to bell picture • Explains his choice in terms of what it knows • The word “Music,” plus a memory of hearing bells Some methods for localizing brain funcEon • Transcranial magneEc sEmulaEon (TMS) – Creates temporary (!) lesions – Allows experimental designs • FuncEonal magneEc resonance imaging (fMRI) – Measures blood flow, which increases to Essue where neurons are firing faster – Inferences about funcEon depend on subtrac.ve method + Some methods for localizing brain funcEon • Lesions – E.g., severed corpus callosum – Inference: the damaged Essue supported the impaired funcEon – Are these experiments? • No; there’s no manipulaEon SubtracEve method Looking at a s.mulus Looking at blank screen - Difference = Inference: Looking at the sEmulus acEvates posterior corEcal areas Good internal validity requires careful design of control condiEons 1 The neuron Structure: FuncEon: Dendrites Soma Axon Inputs ComputaEon Output Neurons SensaEon -­‐ -­‐ ++ Polariza.on: Imbalance of electrical charges across cell membrane ComputaEon: How polarized am I? If depolarized, then fire: Propagate depolarizaEon down axon This propagaEon is an ac.on poten.al (“spike”) AcEon potenEal Synapses Synapse: Small gap between axon terminal and dendrite Bridged by neurotransmiders released when a spike arrives Some neurotransmiders add +’s, some add -­‐’s Excitatory synapses add +’s to the soma + + -­‐ -­‐ -­‐ ++ Each spike travels at constant speed The firing rate (# spikes/second) determines signal strength Traffic analogy: strong signal = more cars (same speed) Signal strength Inhibitory synapses add -­‐’s to the soma Signal strength 2 SensaEon • SensaEon begins with transduc.on: – Light/sound/pressure to neural signals – Vision: Photoreceptor (rods, cones) • Ends with percepEon of objects – Somewhere in the cortex – Many stages in between RecepEve field of a ganglion cell Dim Bright • Which ganglion cell(s) are firing at baseline? – B and D • Which ganglion cell(s) are firing above baseline? – A • Which ganglion cell(s) are firing below baseline? – C 3 Dim Bright The Hermann grid • Ganglion cells project topographically to primary visual cortex • There, the brain detects rows of cells firing above or below baseline – So detects edges in the world – Edges are important for percepEon The Hermann grid - - + - - + - - + - - Ganglion cells at intersections send weaker signals than their neighbors The brain interprets the weaker signal as less light hitting the “+” region The Hermann grid Why do the spots go away when you foveate them? The fovea has higher visual acuity (ganglions there have smaller receptive fields) 4