Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Jeopardy Category – “Age is in the Eye of the Beholder….” (Geriatric Medicine) Value 100 200 300 400 500 The “ANSWER” 1.5 million Americans reside in this type of setting. This is defined as an elevated TSH, normal free T3 and free T4 levels, and no clinical features hypothyroidism This term is applied to a patient in whom the bone mineral density that is 2.5 standard deviations below the peak bone mass of a young woman between the ages of 25 and 30 AND who has experienced a previous fracture. The CORRECT QUESTION What is a nursing home? Entrapment of the purely sensory lateral femoral cutaneous nerve produces a syndrome of anterolateral thigh anesthesia and/or paresthesias. According to Marshal Folstein, MD, when administering the Mini-Mental State Exam to a blind patient, the questionnaire should be scored based on these many points. (i.e. the score’s denominator). What is meralgia paresthetica? COMMENTS What is subclinical hypothyroidism? What is established osteoporosis? What is 30? 4 items require sight – naming objects, reading and obeying a written command, sentence writing and drawing overlapping pentagons. “Osteoporosis” applies to only a BMD loss of greater than 2.5 standard deviations. The difference between “osteoporosis” and “established osteoporosis” is important because it impacts on future fracture risks. According to Dr. Folstein, extenuating factors like blindness and illiteracy should be noted; however, the MMSE is always to be scored on the basis of 30 points. Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Jeopardy Category – “Annie, Annie..are you okay?” (New ACLS Guidelines) ---Circulation, August 22, 2000, Vol. 102 (suppl 1) Value 100 The “ANSWER” The presence of family members at a resuscitation scene has this type of recommendation. The CORRECT QUESTION What is a Class IIb positive recommendation? 200 The new guidelines suggest that the term “DNR” be changed to this. There are three known cardiac arrest variables that predict outcome of resuscitation. These are two of them. What is “DNAR” (Do Not Attempt Resuscitation)? What are: (1) witnessed arrest, (2) initial rhythm and (3) “system variables” (i.e. time to CPR, defibrillation and ACLS)? What is 10-20 minutes? 300 400 Vasopressin is a newly recommended agent in the ACLS protocol. It is an antidiuretic hormone that becomes a powerful vasoconstrictor at higher concentrations. This is the half-life of vasopressin. 500 (DAILY DOUBLE) These are the four anti-arrhythmics (Class Indeterminant or IIb acceptable) in medication sequence and their initial dosages in shock-refractory VF/VT. What are 1) Amiodarone 300mg IV push 2) Lidocaine 1.0-1.5 mg/kg IV push 3) Magnesium sulfate 1-2gm IV (in torsade de pointes or hypomagnesemic states) 4) Procainamide 30mg/min in refractory VF (maximum dose 17mg/kg) COMMENTS Note that family presence at resuscitative efforts is not a spur-of-the-moment offer, extended or not extended at the whim of supervising physicians. Rather, family presence at resuscitative efforts requires a formal program, with advance planning, assigned roles, and even rehearsals. “Ethical Aspects of CPR and ECC” article “Patient variables” that predict outcome include comorbid illness and medications. (“Ethical Aspects of CPR and ECC” article) Vasopressin is a Class IIb positive recommendation. It possesses the positive effects of epinephrine without the adverse effects. It does not cause skeletal muscle vasodilatation or increased myocardial oxygen consumption since it has no β-adrenergic activity. The new guidelines relegate adrenergic agents, antiarrhythmic agents and buffer therapy to secondary roles in VF and non-VF patients. Credible evidence to confirm benefits due to these agents do not exist. it was not until the 1990s that researchers discovered the dismal truth that antiarrhythmic drugs were acting more like proarrhythmic agents. Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Jeopardy Category – “It did what?!!” (Medication Side Effects) Value 100 The “ANSWER” This antiepileptic is known for gingival hyperplasia. The CORRECT QUESTION What is phenytoin? COMMENTS Likely due to the synergistic overexpression of c-Myc and bcl-2 oncoprotein induced by phenytoin. May also be induced by cyclosporin A and nifedipine 200 300 400 500 This antibiotic class is known for photosensitivity and permanently discoloring teeth when taken by children < 8 yo.. The nurse pages you about a patient who has become erythematous since she started the infusion of this antibiotic. The patient’s vitals are stable. You tell her to give the patient some benadryl and slow down the rate of infusion because it is not an allergic reaction. You are doing missionary work overseas and have only a limited repertoire of antibiotics at your disposal. You decide to do treat a clear case of bacterial meningitis with chloramphenicol. You must keep this in mind this potential but important adverse event. Metformin is an oral antihyperglycemic agent that belongs to the biguanide class of medications. Metformin is reported to cause lactic acidosis at a rate of 0.1 case per 1000 patient years. This predecessor medication was withdrawn due to a high incidence of lactic acidosis. What is tetracycline? What is vancomycin? (red-man syndrome) What is aplastic anemia? What is phenformin? This is a histamine-mediated event. Although it can be associated in rare instances with hypotension, patients should not be labeled with a vancomycin allergy. Slowing the rate of infusion or treatment with H1 receptor blockers is usually sufficient. The incidence is 1 in 30,000. When the bone marrow aplasia is pancytopenic, the fatality rate is high. In those who recover, there is a higher rate of acute leukemia. Goodman and Gilman’s “The Pharmacological Basis of Therapeutics” Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Jeopardy Category – “See one, Hear one, Touch one” (Physical Exam) Value 100 200 300 400 500 The “ANSWER” This part of the breast tissue extends from the upper, outer quadrant into the axilla. When you are manually checking a patient’s blood pressure, you are listening for these. The Achilles reflex tests these nerve roots. These glands lie in the cleft between the labia minora and the vaginal orifice. The CORRECT QUESTION What is the Tail of Spence? This landmark is defined by the costal margin inferiorly, the sixth rib superiorly and the left midaxillary line laterally. What is Traube’s Triangle or Traube’s Semilunar Space? COMMENTS What are Korotkoff sounds? What are S1 and S2? What are Bartholin Glands (or greater vestibular glands)? Skene’s glands (or periurethral glands) lie on either side of and posterior to the urethra. Dullness to percussion over this landmark is suggestive of splenomegaly. (Harrison’s, 14th Ed.) Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Jeopardy Category – “Who’s Who” (Physicians to Know) Value 100 200 300 400 500 The “ANSWER” An English physician who discovered the vaccination for smallpox. An English physician who discovered the true nature of the circulation of blood and the function of the heart as a pump. A Canadian physician who became a professor at Johns Hopkins and had a key role in transforming the organization and curriculum of medical education in the U.S. This American physician was responsible for organizing the concept of the blood bank. This Arabic physician was the first to explain the contagious nature of tuberculosis. His famous medical work, al-Qunun (“Canon of Medicine”), helped form the foundation on which Medieval Europe built its medical sciences. The CORRECT QUESTION Who is Edward Jenner? COMMENTS 1749-1823 Who is William Harvey? 1578-1657 Who is Sir William Osler? 1849-1919 Who is Charles Drew? 1904-1950 Who is Ibn Sina? (or Avicenna) 980-1037 Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Double Jeopardy Category – “Matters of the Heart” (Cardiovascular System) Value 200 The “ANSWER” This agent is the cause of most cases of viral myocarditis. The CORRECT QUESTION What is Coxsackie virus B? COMMENTS 400 With a Swan Ganz catheter, this is the reason why the pulmonary artery diastolic pressure approximates the pulmonary capillary wedge pressure (i.e. left atrial pressure). The upper limit of the normal Q-T interval. What is low pulmonary circulation resistance? Braunwald, 5th Ed, pg 189, vol 1 600 800 This is what the first 3 positions of the NASPE/BPEG Generic Pacemaker Code stand for. 1000 In Ashman phenomenon, the onset of aberrant complexes is preceded by a relatively longer RR interval. The rate of the aberrant complexes is usually 300 per minute. This is the reason why the aberrant complexes usually have a right bundle branch block (RBBB) pattern. What is QTc 0.44 sec? (corrected for heart rate). Position I = Chamber(s) paced Position II = Chamber(s) sensed Position III = Response to sensing Why is the refractory period of the right bundle branch is normally longer than that of the left bundle branch? NASPE = North American Society of Pacing and Electrophysiology, BPEG = British Pacing and Electrophysiology Group From page 182, “Electrocardiography of Clinical Arrhythmias” by Charles Fisch and Suzanne Knoebel. Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Double Jeopardy Category – “1 + 1 = 2” (Mathematical Equations) *** Teams should submit answers in writing *** Value 200 The “ANSWER” Formula used to calculate the creatinine clearance. The CORRECT QUESTION What is COMMENTS (For women, multiply the result by 0.85) (140 – age) x wt in kg 72 x serum creatinine 400 Formula used to calculate the fractional excretion of sodium. What is [Urine sodium] x [Plasma creatinine] [Urine creatinine] x [Plasma sodium] 600 Formula used to calculate the free water deficit. Or (0.6 x wt) x ((Na – 140)/140) What is (0.6 x wt in kg) x ((Na/140) – 1) 800 Formula used to correct the measured calcium level for the patient’s albumin. What is measured calcium + 0.8 (4 – albumin) 1000 Formula used to correct the phenytoin level for the patient’s albumin. What is (Phenytoin level) ((0.1 x albumin) + 0.01) Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Double Jeopardy Category – “The little things in life!” (ID) Value 200 The “ANSWER” This the “d” in “Td”. The CORRECT QUESTION What is diphtheria? (Corynebacterium diphtheriae) 400 An acutely infectious inflammatory colitis which is associated with dysentery although most patients in the industrialized world only have a mild watery diarrhea. Indianapolis had a small epidemic of this 2 years ago. What is shigellosis? 600 The spores of this gram-positive bacilli with a polypeptide capsule can be used a biological weapon. When the spores are inhaled and germinate, they cause hemorrhagic necrosis and edema of the mediastinum. What is anthrax or Bacillus anthracis? 800 (DAILY DOUBLE) This toxin is one of the most deadly in the world and causes a descending paralysis starting with the cranial nerves and progressing caudally. Be careful of what you eat! What is botulism? 1000 These two viruses are the only current members of the Filoviridae family. When they infect humans, they cause an acute systemic illness which includes headache, myalgias, pharyngitis, rash and hemorrhagic manifestations. The viruses are zoonotic, but their natural reservoirs have not been discovered. What are the Marburg and Ebola viruses? COMMENTS Respiratory anthrax has a biphasic clinical pattern. The initial 1-3 days consists of malaise, low-grade fever and cough. The second phase is sudden and consists of high fever, tachypnea, tachycardia, and shock. Survival is rare. Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Double Jeopardy Category – “That is what they tell me” (Practice Guidelines) Value 200 The “ANSWER” This type of antibiotic should be initiated in patients with severe exacerbations of chronic obstructive pulmonary disease (in a patient with no findings on the admission chest x-ray). The CORRECT QUESTION What are narrow-spectrum antibiotics (such as amoxicillin, bactrim and tetracycline) as reasonable first-line agents? 400 Prostate screening should be considered in men older than 50 and with a life expectancy of this many years. What is a life expectancy of at least 10 years? 600 The type of antibiotics that should be administered to a patient with purulent discharge from the nares or throat. What is no antibiotic treatment is required? 800 Intravenous nitroglycerin should be What is 24 to 48 hours? administered to pts with an acute MI and CHF, a large anterior infarction, persistent ischemia or hypertension for this long. These are the criteria for which cervical 1. Older than 65 years old cancer screenings can be stopped in 2. Two satisfactory smears women who have been regularly screened. 3. No abnormal smears in the previous 9 years 1000 COMMENTS No randomized, placebo-controlled trials have demonstrated the superiority of the newer, broadspectrum antibiotics in acute exacerbations of COPD. There are randomized, placebo-controlled trials supporting the use of the amoxicillin, bactrim and tetracycline. [ACP-ASIM and the American College of Chest Physicians (Apr 2001)] United States Preventive Services Task Force (1996), American College of Preventive Medicine (1998), and American Urological Association (1999) Antibiotics should not be used to treat nonspecific upper respiratory tract infections in previously healthy adults. Purulent secretions from the nares or throat do not predict bacterial infection or benefit from antibiotic treatment. Antibiotic treatment of adults with non-specific upper respiratory tract infections does not enhance illness resolution or prevent complications. [ACP-ASIM (March 2001)] American College of Cardiology/American Heart Association (1999) For women who have never been previously screened, Pap smears can be stopped after age 65 and if there have been three normal annual smears. [American College of Preventive Medicine (1996)] Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Double Jeopardy Category – “Is this bean dip?” (Nephrology) Value 200 The “ANSWER” The 4 primary types of kidney stones. The CORRECT QUESTION What are struvite, uric acid, calcium and cystine stones? 400 This type of glomerulopathy is seen with hepatitis B and C. What is membranous glomerulopathy? 600 A 30 year-old patient presents with painless gross hematuria 2 days after receiving a flu shot. He reports a similar episode 2 months ago after he had a sore throat. This is the most likely diagnosis. What is IgA nephropathy or Berger’s Disease? 800 (DAILY DOUBLE) Three classes of antihypertensives can be used to reduce proteinuria in proteinuric patients. 1000 Aluminum hydroxide can be used as a phosphate binder; however, its use has declined significantly because aluminum can cause osteomalacia through this mechanism. What are (1) angiotension converting enzyme (ACE) inhibitors, (2) angiotensin II receptor blockers, and (3) non-dihydropyridine calcium channel blockers (e.g. verapamil and diltiazem)? What is depression of PTH biosynthesis? COMMENTS Brenner and Rector’s “The Kidney”, 6th Ed. Medical Jeopardy “Doctor’s Dilemma” 2001 ACP-ASIM Indiana Associates Scientific Meeting All answers must be stated in the form of a question Medical Final Jeopardy Category – “Bugs” (ID) Value Variable The “ANSWER” This alphavirus is distributed primarily in the Americas. Infections are usually heralded by headaches, high fevers, polyarthritis, and rash. In cases in which there is CNS involvement, these initial symptoms are followed by mental confusion and somnolence and may progress to coma. The last epidemic was documented in 1941 in the western US and Canada and involved 3400 cases. The vector is Culex tarsalis, a mosquito. The CORRECT QUESTION What is the Western Equine Encephalitis virus? COMMENTS Three alphaviruses cause human disease in the United States: Eastern Equine Encephalitis virus, Western Equine Encephalitis virus, and Venezuelan Equine Encephalitis virus. As the name implies, all three viruses were initially isolated from the brains of horses. The incidence of alphavirus encephalitis has been declining the last 12 years. Since 1994, there have been no reported cases of Western Equine Encephalitis. This virus is considered to be a potential agent for bioterrorism.