14 people singapore health MAY–JUN 2013 Solving mysteries, one clue at a time Being a pathologist may not be quite what TV dramas make it out to be, but it is similar to doing detective work Assoc Prof Lim discovered his passion for pathology when he was an undergraduate at the National University of Singapore. The subject provided him with fascinating insight into the fundamentals of human physiology and disease. “As a medical student, I liked looking at slides (of tissue samples), as the information they contain is very ‘visual’. The study of pathology gives me an understanding of how and why disease occurs, and how its symptoms present themselves,” he said. We’re like medical detectives. we try to find out what is wrong with a patient. Photos: associate professor tony Lim associate professor tony lim, senior consultant, pathology department, singapore general hospital , on what it’s like to be a pathologist By karen tee “For example, if a patient experiences pain, weight loss or a low blood count, his surgeon or gastroenterologist might do a scope in the stomach and see an ulcer or unidentified mass. They will perform a biopsy and send the sample to a pathologist like me, who can then tell them if it is benign, cancer or just an infection.” Assoc Prof Lim works in the histopathology (the examination of tissues under a microscope to study a disease) section of the Pathology Department. The department processes about 12 million tests a year, while the histopathology section gets about 40,000 diseaserelated specimens annually. Tests are run on the samples to find out whether a patient is suffering from cancer, or an inflammatory or infectious disease. Bird-watching is like pathology, said Associate Professor Tony Lim (below). In both cases, he has to deduce the identity of a subject – be it a bird or disease – by looking for a variety of clues. Photo: alecia neo I T may be hard to see a link between bird-watching and pathology, but for Associate Professor Tony Lim, his hobby and profession share many similarities. “Bird-watching is like pathology. When I spot a bird, all I see at first is its general appearance. To identify it, I have to use other information, such as the tree it is in, the kind of calls it makes and the way it jumps and flies,” said Assoc Prof Lim, Senior Consultant, Pathology Department, Singapore General Hospital (SGH). He goes bird-watching with the Nature Society about once a month. “Similarly, when I look at a tissue sample through a microscope, all I see at first is the overall pattern and the colours of the sample. I then study other information to diagnose the disease. Assoc Prof Lim has had some dramatic moments in his career. He recalled a patient whose condition kept deteriorating even though doctors were treating the symptoms of his disease thoroughly. It was only after he studied a tissue sample from the patient that a viral infection was found to be the root of the problem. The patient recovered soon after he received treatment for the infection. Incidents like this could have come straight from an episode of CSI: Crime Scene Investigation, but Assoc Prof Lim joked that such shows give many people the mistaken impression that a pathologist “works on dead bodies”. Forensic pathologists are the ones who examine dead bodies to determine the cause of death. Still, all pathologists need to think like detectives. Assoc Prof Lim said: “We have to be meticulous and hardworking. We need to be inquisitive and good with our eyes (to spot clues). We need to be able to match what we see with what we know about diseases, which have tell-tale patterns. “In a way, we are like medical detectives. We try to find out what is wrong with a patient.”