Takeda’s History Takeda’s History Takeda’s history has been one of ongoing self-transformation through the ages to achieve progress in drug innovation. Takeda began operations in 1781 when Chobei Takeda I started a business selling traditional Japanese and Chinese medicines in Doshomachi, Osaka. Following Japan’s Meiji Restoration in the late 1860s, Takeda was one of the first companies in Japan to turn its Founder, Chobei TakedaⅠ attention to Western medicine. In 1895, the company established its own factory, thereby achieving its transformation by becoming a pharmaceutical manufacturer. In 1950, Takeda increased its reputation for expertise in “drug innovation” by introducing Panvitan, Japan’s first multivitamin, and developing antibiotics and other drugs. With these strides in business, Takeda in 1940 stipulated its original credo in a written form named “Nori,” which states it is the most fundamental and important aspect of company management to conduct business while being aware of public nature of the business and to contribute to the society. In the 1960s, Takeda, targeting an international market, began the full-scale start of operations outside Japan. Extending operations to other Asian countries came first. Overseas activities were then extended to Europe and the U.S. in the 1970s and 1980s. In the late 1980s and early 1990s, Takeda accelerated its progress toward becoming a world-class pharmaceutical company by launching its four international strategic products. As of March 2010, Takeda had its global presence in 26 countries overall. Over the years, Takeda has repeatedly translated challenges into the energy and sustained its growth. Takeda will continue to move forward and evolve while looking ahead to future challenges and opportunities. 2005 Ramelteon (insomnia treatment) launched in the U.S. 1999 Pioglitazone Hydrochloride (type 2 diabetes treatment) launched in the U.S. and Japan 1997 Candesartan Cilexetil (angiotensin Ⅱ receptor antagonist and anti-hypertensive agent) launched in Europe 1991 Lansoprazole (proton pump inhibitor and anti-peptic ulcer treatment) launched in Europe Takeda research facility in 1939 1985 Began operations in the U.S. 1989 Leuprorelin Acetate (prostate cancer, breast cancer and endometriosis treatment) launched in the U.S. and Europe 1978 Began operations in Europe 1962 Began operations in Asia 1954 Alinamin, a vitamin B1 derivative, launched 1950 Panvitan,the first multivitamin, launched in Japan 1895 Pharmaceutical manufacturing business launched 1781 Foundation 26 International strategic products Takeda’s History Jun. to Jul. 2010 Feb. 2010 Six new products launched in Japan Mepact (non-metastatic osteasarcoma treatment) launched in Europe Mar. 2009-Feb. 2010 Expanded own sales network into 12 more countries Mar. 2009 ULORIC (treatment for the management of hyperuricemia in patients with gout) launched in the U.S. Apr. 2009 Reorganized global operating structure Feb. 2009 DEXILANT (treatment for acid reflux disease) launched in the U.S. 2008 Acquired Millennium Pharmaceuticals, Inc 2008 Restructured U.S. operations Own Sales Network Expanded to Include 12 More Countries Millennium research laboratory in 2009 Significant Events of 2009 and 2010 Launch of DEXILANT for the Treatment of Acid Reflux Disease In February 2009, Takeda started selling DEXILANT (generic name: dexlansoprazole; former name: KAPIDEX), a treatment for acid reflux disease, in the U.S. This drug is positioned as the successor to the peptic ulcer treatment Prevacid (generic name: lansoprazole), which has been one of Takeda’s international strategic products. Launch of ULORIC for the Management of Hyperuricemia in Patients with Gout In March 2009, Takeda started selling ULORIC (generic name: febuxostat), a treatment for hyperuricemia in patients with gout, in the U.S. This is the first new treatment for gout in about 40 years. Reorganization of Global Operating Structure In April 2009, Takeda created three corporate-level centers of excellence led by executives in the newly created positions of Chief Scientific Officer, Executive Vice President International Operations, and Chief Administrative Officer. This gives us a further strengthened global operating structure that can be more responsive to rapid changes taking place in the pharmaceutical industry’s operating environment. The new framework supports faster and more flexible decision-making as well as better lines of communication. During fiscal 2008 and 2009, Takeda entered 12 new countries: Canada, Spain, Portugal, Ireland, Mexico, Sweden, Norway, Denmark, Belgium, Luxembourg, Turkey and Brazil. Takeda expanded its global presence to 26 countries overall (including Japan). This substantially increased its coverage of the global pharmaceutical market to 84 percent. Launch of Mepact for Non-Metastatic Osteosarcoma (Malignant Bone Cancer) Treatment In February 2010, Takeda started selling Mepact (generic name: mifamurtide), a treatment for non-metastatic osteosarcoma, in Europe. The first new drug in 20 years for this disease, Mepact is expected to help people suffering from osteosarcoma fight against the disease. Launch of Six New Products in Japan Takeda started selling six drugs in Japan in June and July 2010: NESINA (generic name: alogliptin benzoate), a treatment for type 2 diabetes; ROZEREM (generic name: ramelteon), an insomnia drug; Vectibix (generic name: panitumumab), anti-cancer agent; METACT (a fixed-dose combination of Actos and metformin) with two active ingredients, each with a different action mechanism, that is a treatment for type 2 diabetes; UNISIA (a fixed-dose combination of Blopress and amlodipine besilate), a treatment for hypertension; and Actos Orally Disintegrating Tablets (generic name: pioglitazone hydrochloride), a treatment for type 2 diabetes that offers improved ease of administration. 27