BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Rosemarie Chirco D’Angelo
Postdoctoral Fellow
EMAIL
LAB PHONE
rchirco@med.umich.edu
7-9923
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Wayne State University, Detroit, Michigan
Wayne State University, Detroit, Michigan
Michigan State University, East Lansing, Michigan
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
Ph.D.
M.S.
B.S.
2003-08
2001-03
1996-00
Cancer Biology
Basic Medical Science
Human Biology
A. Professional Experience and Honors
Research and Professional Experience
2/2009-Present Postdoctoral Fellow, University of Michigan Cancer Center
Principle Investigator: Max Wicha, M.D.
Project: The Activation and Tumorigenesis of the Notch Stem Cell Pathway in Breast
Cancer Cells
9/2003-1/2008
Graduate Student Research Assistant, Wayne State University School of Medicine
Ph.D. Candidate, Graduate Program in Cancer Biology
Dissertation Mentor: Hyeong-Reh Choi Kim, Ph.D.
Dissertation Project: The Novel Functions of the Tissue Inhibitor of Metalloproteinase (TIMP1): Inhibition of Apoptosis and Induction of an Epithelial-Mesenchymal Transition
5/2002-8/2003
Graduate Research Assistant at Barbara Ann Karmanos Cancer, Detroit, Michigan
Essay Advisors: Drs. R. Everson, M.D., M.P.H & J. Eliason, Ph.D.
Essay Project: Using the Comet Assay (single-cell gel electrophoresis) to Observe DNA
damage of Breast Cancer Cells After Treatment With Chemotherapeutic Drugs
Honors
2008 AACR-Aflac, Incorporated Scholar-in-Training Award for the AACR Annual Meeting, supports the most
highly rated papers presented by AACR Associate Members
2007 Wayne State University School of Medicine, Department of Pathology Academic Student Achievement
Award
2007 Wayne State University School of Medicine Graduate Student Research Day Award for Best Oral
Presentation
2006 Nomination for “Future Leaders, New Directions” symposium at the AACR Annual Meeting
2006 Wayne State University School of Medicine Outstanding Graduate Student Award
2006 Wayne State University School of Medicine, Department of Pathology Academic Student Achievement
Award
2006 Wayne State University Graduate Student External Support Award
B. List of Select Publications
Chirco, R., Liu, X-W., Fridman, R., and Hyeong-Reh Choi Kim. TIMP-1 induces an epithelial mesenchymal
transition via upregulation of the transcription factor Twist in human breast epithelial cells. Manuscript in
preparation.
Liu, X-W., Chirco, R., Jung, K-K., Bernardo, M.M, Fridman, R., and Kim, H.R.C. Structural basis for TIMP-1
interaction with CD63: The MMP-inhibitory domain of TIMP-1 is not necessary for induction of CD63-mediated
cell survival signaling. Manuscript in preparation.
Clark MK, Scott SA, Wojtkowiak J, Chirco R, Mathieu P, Reiners JJ Jr, Mattingly RR, Borch RF, Gibbs RA.
2007. Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as
farnesyltransferase inhibitors. J Med Chem. 50(14):3274-82.
Jung, K-K., Liu, X-W., Chirco, R., Fridman, R., and Kim, H.R.C. 2006. Identification of CD63 as a Tissue
Inhibitor of Metalloproteinase-1 interacting cell surface protein. EMBO J, 25(17): 3934-42.
Chirco, R., Liu, X-W., Jung, K-K., and Kim, H.R.C. 2006. Novel functions of TIMPs in cell signaling. Cancer
Metastasis Rev, 25: 99-113.
ABSTRACTS AND PRESENTATIONS
Chirco, R, Won, J., Fridman, R., and Hyeong-Reh Choi Kim. Sept 2008. TIMP-1 induces an epithelial
mesenchymal transition via upregulation of the transcription factor Twist in human breast epithelial cells. Third
Annual NIH National Graduate Student Research Festival, Bethesda, MD.
Chirco, R, Won, J., Fridman, R., and Hyeong-Reh Choi Kim. June 2008. TIMP-1 induces an epithelial
mesenchymal transition via upregulation of the transcription factor Twist in human breast epithelial cells. The
DOD Era of Hope Meeting, Baltimore, MD.
Chirco, R, Won, J., Fridman, R., and Hyeong-Reh Choi Kim. April 2008. TIMP-1 induces an epithelial
mesenchymal transition via upregulation of the transcription factor Twist in human breast epithelial cells. The
AACR Annual Meeting, San Diego, CA.
Chirco, R. and Hyeong-Reh Choi Kim. July 2007. TIMP-1 induces an epithelial mesenchymal transition via
upregulation of the transcription factor Twist in human breast epithelial cells. The Edward A. Smuckler
Memorial Workshop: Pathobiology of Cancer (AACR) Workshop in Cancer Research), Snowmass Village, CO.
Chirco, R and Hyeong-Reh Choi Kim. July 2007. TIMP-1 induces an epithelial mesenchymal transition via
upregulation of the transcription factor Twist in human breast epithelial cells. The 2nd Annual Cancer Biology
Training Consortium, a meeting of directors and student representatives of US Cancer Biology Training
Programs, Monterrey, CA.
Chirco, R, Jung, K-K., Liu, X-W, and Hyeong-Reh Choi Kim. June 2006. TIMP-1 regulation of
tetraspanin/integrin survival signaling pathways affecting apoptosis, cell-cell adhesion, morphology and polarity
of breast epithelial cells. Gordon Research Conference on Basement Membranes, Barga, Italy.
Chirco, R, Won, J., and Hyeong-Reh Choi Kim. September 2007. TIMP-1 induces an epithelial mesenchymal
transition via upregulation of the transcription factor Twist in human breast epithelial cells. Wayne State
University School of Medicine Graduate Student Research Day, Detroit, MI
Chirco, R. and Hyeong-Reh Choi Kim. December 2006. A novel function of TIMP-1 for cell signaling in breast
cancer. Annual Retreat for the Protease Program at KCI, Detroit, MI.
Chirco, R, Jung, K.K., Lui, X.W, Fridman, R., and Hyeong-Reh Choi Kim. September 2006. TIMP-1
regulation of tetraspanin/integrin signal transduction pathways. Wayne State University School of Medicine
Graduate Student Research Day, Detroit, MI
C. Research Support
Active
9/2009-current
National Cancer Institute
Title: University of Michigan’s Cancer Biology Program Training Grant
PI: M. Imperiale
Completed
9/2006-9/2008
U.S. Army Medical Research and Materiel Command (USAMRMC)
Title: DOD Breast Cancer Research Program (BCRP) Predoctoral Traineeship Award
Proposal: Tissue inhibitor Of Metalloproteinases (TIMP-1) regulation of tetraspanin/integrin
signal transduction pathways (BC061743).
PI: Rosemarie Chirco; % effort 100%, Award $30,000/year
Sponsor: Hyeong-Reh Choi Kim, PhD
8/2006-8/2008
National Cancer Institute
Title: Cancer Biology Program Training Grant (T32 CA009531)
PI: L. Matherly, Ph.D., declined due to overlap with DOD Traineeship
6/2002-8/2002
Karmanos Cancer Institute (Detroit, MI)
Title: Basic Medical Science Summer Research Fellowship
PI: R. Everson, M.D., M.P.H, Award $2,500 stipend