GE Healthcare
Life Sciences
Data file 29-0483-67 AA
Single-use mixing systems
Xcellerex™ XDM Quad Mixing System
GE Healthcare Life Sciences’ disposable mixing systems
are designed for convenient and efficient mixing of buffer,
media, intermediates and product, as well as other process
fluids. The single-use system eliminates the hassle of timeconsuming and costly clean-in-place (CIP), steam-in-place
(SIP) procedures, and cleaning validation. The result is
efficient processing and rapid batch-to-batch turnover time.
The Xcellerex XDM Quad Mixing System is available in singlewall stainless steel (Fig 1), jacketed stainless steel (for heating
and cooling applications), or polypropylene (Fig 2). The
system comprises an integrated rigid container, complete
with an agitation system and controls that use an irradiated
USP Class VI single-use ULDPE fluid contact layer bag. The
system delivers flexibility with the availability of two standard
bag types that include varying numbers of tubing lines
and connections, and sampling and sensing capabilities to
accommodate a wide array of applications (Fig 3). Custom bag
configurations are also available on request. Key features of
the bag and rigid container also permit seamless transitioning
between powder-liquid and liquid-liquid mixing applications.
Fig 1. Xcellerex XDM Quad Mixing System is available in 50L, 100 L , 200 L,
500 L, and 1000 L sizes.
A disposable impeller is welded into the bottom of the bag
assembly (Fig 4). The engagement between motor and
disposable impeller is via a robust magnetic coupling, imparting
high torque and rapid mixing capability to the system.
Key features and benefits:
• Powerful, integrated magnetic agitator with compact
VFD and AC motor
• Square configuration offers enhanced mixing efficiency
through natural baffling effect
• Workable heights and low center of gravity increase
level of safety
• Bottom is slanted on two planes for minimal low bag
hold-up volume
• Fitted square bag minimizes bag wrinkles
imagination at work
Fig 2. Xcellerex XDM Quad Mixing System is available in various materials
including polypropylene (pictured here), single-wall stainless steel (Fig 1), or
jacketed stainless steel (for heating and cooling applications).
• Real-time sensing and sampling capability via mixer
window and bag probe ports, sampling port and
thermowell for non-invasive temperature sensing
• 500 and 1000 L systems equipped with removable door for
easy bag loading
• All mixers are CE and UL approved and GMP compliant
System specifications1
Xcellerex XDM QUAD-S (stainless steel) Mixing System
Dimensions
50 L
100 L
200 L
Exterior (W × H × D)
848 × 1067 × 544 mm 851 × 1067 × 610 mm 940 × 1067 × 673 mm 1227 × 1443 × 897 mm 1405 × 1443 × 1100 mm
(33.4 × 42 × 21.4 in)
(33.5 × 42 × 24 in)
(37 × 42 × 26.5 in)
(48.3 × 56.8 × 35.3 in)
(55.3 × 56.8 × 43.3 in)
102 × 51 mm (4 × 2 in)
Jacket volume
Weight
System weight (empty)
Construction material
Container
NA
68 kg (150 lbs)
82 kg (181 lbs)
140 kg (309 lbs)
Acrylic
Casters
SS/polyurethane (non-marring)
Type
AC motor
HP
0.26
Power rating
197 W
RPM
0 to 200
Power requirement
115 V or 230 V: (50/60 Hz)
Functionality
Run/stop, forward/break/reverse
Power cord
3.05 m (10 ft)
Washdown
Motor is IP66, CE certified/drive is IP65 NEMA 4×, CE certified
Xcellerex XDM QUAD-T (jacketed stainless steel) Mixing System
50 L
100 L
200 L
Exterior (W × H × D)
848 × 1067 × 544 mm 940 × 1067 × 681 mm 978 × 1067 × 681 mm 1280 × 1443 × 975 mm 1488 × 143 × 1207 mm
(33.4 × 42 × 21.4 in)
(37 × 42 × 26.8 in)
(38.5 × 42 × 26.8 in)
(50.4 × 56.8 × 38.4 in)
(58.6 × 56.8 × 47.5 in)
Jacket volume
System weight (empty)
102 × 51 mm (4 × 2 in)
1.2 L
2L
2.65 L
5.8 L
9.1 L
91 kg (200 lbs)
107 kg (236 lbs)
173 kg (381 lbs)
228 kg (503 lbs)
359 kg (792 lbs)
Container
304 L stainless steel
Insulation
Insulation is non-asbestos, chloride free, and coated with Thurmalox™ mastic material
Acrylic
Casters
SS /polyurethane (non-marring)
Type
AC Motor
HP
0.26
Power rating
197 W
RPM
0 to 200
Power requirement
115 V or 230 V: (50/60 Hz)
Functionality
Run/stop, forward/break/reverse
Power cord
3.05 m (10 ft)
Washdown
Motor is IP66, CE certified/drive is IP65 NEMA 4×, CE certified
Xcellerex XDM QUAD (polypropylene) Mixing System
50 L
100 L
Exterior (W × H × D)
686 × 1143 × 572 mm 838 × 1041 × 699 mm 965 × 1016 × 826 mm 1029 × 1219 × 1181 mm
(27 × 45 × 22.5 in)
(33 × 41 × 27.5 in)
(38 × 40 × 32.5 in)
(40.5 × 48 × 46.5 in)
Weight
System weight (empty)
Construction material
Container
Insulation
Lid
Casters
Type
HP
Power rating
RPM
Power requirement
Functionality
838 × 838 × 838 mm
(33 × 33 × 33 in)
~ 41.7 mm (1.64 in) per meter (3.28 ft)
102 × 51 mm (4 × 2 in)
Jacket volume
NA
52 kg (115 lbs)
65 kg (143 lbs)
83 kg (183 lbs)
138 kg (304 lbs)
Polypropylene
NA
Acrylic
SS/polyurethane (non-marring)
AC motor
0.26
197 W
0 to 200
115 V or 230 V: (50/60 Hz)
Run/stop, forward/break/reverse
Power cord
3.05 m (10 ft)
Washdown
Motor is IP66, CE certified/drive is IP65 NEMA 4×, CE certified
All specifications are subject to change without notice.
29-0483-67 AA
500 L
394 × 394 × 394 mm 508 × 508 × 508 mm 635 × 635 × 635 mm
(15.5 × 15.5 × 15.5 in)
(20 × 20 × 20 in)
(25 × 25 × 25 in)
Slope to drain
2
200 L
Container interior (W × H × D)
Caster dimensions (ø × W)
1
838 × 838 × 838 mm 1041 × 1041 × 1041 mm
(33 × 33 × 33 in)
(41 × 41 × 41 in)
~ 41.7 mm (1.64 in) per meter (3.28 ft)
Lid
Motor/VFD
1000 L
394 × 394 × 394 mm 508 × 508 × 508 mm 635 × 635 × 635 mm
(15.5 × 15.5 × 15.5 in)
(20 × 20 × 20 in)
(25 × 25 × 25 in)
Caster dimensions (ø × W)
Dimensions
500 L
Container interior (W × H × D)
Slope to drain
Motor/VFD
275 kg (606 lbs)
NA
Lid
Construction material
180 kg (397 lbs)
304 L stainless steel (SS)
Insulation
Weight
838 × 838 × 838 mm 1041 × 1041 × 1041 mm
(33 × 33 × 33 in)
(41 × 41 × 41 in)
~ 41.7 mm (1.64 in) per meter (3.28 ft)
Caster dimensions (ø × W)
Dimensions
1000 L
394 × 394 × 394 mm 508 × 508 × 508 mm 635 × 635 × 635 mm
(15.5 × 15.5 × 15.5 in)
(20 × 20 × 20 in)
(25 × 25 × 25 in)
Slope to drain
Motor/VFD
500 L
Container interior (W × H × D)
Single-use bag specifications1
50 L
100 L
200 L
394 × 369 × 394 mm
(15.5 × 14.5 × 15.5 in)
508 × 483 × 508 mm
(20 × 19 × 20 in)
635 × 609 × 635 mm
(25 × 24 × 25 in)
Maximum
55 L
125 L
246 L
571 L
1019 L
Nominal
50 L
100 L
200 L
500 L
1000 L
Minimum (for mixing)
17 L
28 L
44 L
76 L
117 L
< 20 mL
< 20 mL
< 20 mL
< 20 mL
< 20 mL
Dimensions
Dimensions (W × H × D)
Volume
Hold up
Film
Fluid contact layer
1000 L
ULDPE (USP class VI)
Pressure rating (max. operating)
Impeller
500 L
839 × 813 × 839 mm 1041 × 940 × 1041 mm
(33 × 32 × 33 in)
(41 × 37 × 41 in)
2 psi (1 psi)
Number of blades
3
Diameter
191 mm (7.5 in)
Blade height × width
107 × 64 mm (4.2 × 2.5 in)
Blade pitch
57º
Construction material
Molded HDPE impeller with ceramic bearing
Temperature range
2°C to 60ºC (May vary due to specific process conditions)
Powder port dimensions
76 mm (3 in) TC
Sterilization
Gamma irradiated
Single-use bag assemblies1
Basic bag assembly
Port description
A
Fill port: 3" tri-clamp powder addition port, capped
B
C-flex™ tubing, 4’ with clamp, plugged (ID indicated)
Plus bag assembly
50 L
100 L
200 L
500 L
1000 L
50 L
100 L
200 L
500 L
1000 L
×
×
×
×
×
×
×
×
×
×
12.7 mm 12.7 mm 12.7 mm 12.7 mm 19.1 mm 19.1 mm 19.1 mm 19.1 mm 19.1 mm 19.1 mm
(1/2 in) (1/2 in) (1/2 in) (1/2 in) (3/4 in) (3/4 in) (3/4 in) (3/4 in) (3/4 in) (3/4 in)
C
½" ID C-flex tubing, 4’ with clamp, female MPX connector, plugged
NA
NA
NA
NA
NA
×
×
×
×
×
D
1/8" ID C-Flex tubing (36”) Luer lock connection
NA
NA
NA
NA
NA
×
×
×
×
×
E, F
Probe Port: Female Kleenpack™ Connector port for probe connection
NA
NA
NA
NA
NA
×
×
×
×
×
F
Female Kleenpack Connector port for probe connection
NA
NA
NA
NA
NA
×
×
×
×
×
G
Thermowell: for non-invasive temperature sensing
NA
NA
NA
NA
NA
×
×
×
×
×
×
×
×
×
×
×
×
×
×
×
H
Sample Line: 1/8" ID sample line with clamp, and Luer lock connection
I
Harvest/Drain: C-flex tubing, 6’ with clamp, plugged (ID indicated)
1
12.7 mm 12.7 mm 12.7 mm 12.7 mm 19.1 mm 12.7 mm 12.7 mm 12.7 mm 12.7 mm 19.1 mm
(1/2 in) (1/2 in) (1/2 in) (1/2 in) (3/4 in) (1/2 in) (1/2 in) (1/2 in) (1/2 in) (3/4 in)
All specifications are subject to change without notice.
Bag assembly details
Xcellerex XDM Quad Mixing System
options and accessories
The following options are available for Xcellerex
XDM Quad Mixing systems:
• Dual pH/conductivity monitoring System
• pH probe
• Conductivity probe
Fig 3. Xcellerex XDM Quad Mixing System available with two standard bag
assembly types: Basic and Plus.
• RTD probe
• Probe sheath assemblies
• Weight monitoring1 (load cells for stainless steel units)
• Temperature control unit for heating and cooling of
jacketed stainless steel systems
• Temperature monitoring1
• Hopper for powder addition
1
Not available in polypropylene mixers.
Fig 4. The disposable impeller assembly is welded to the bottom of the bag.
29-0483-67 AA
3
Applications and performance data
The mixing systems effective mixing of common cell culture
media (Fig 7).
11.5
100
11.0
80
Corn syrup dissolved (%)
Conductivity (mS/cm)
Xcellerex XDM Quad Mixing System units demonstrate
rapid mixing of common salt solutions (Fig 5). The systems
demonstrate effective mixing even at high viscosities (Fig 6).
10.5
10.0
9.5
9.0
60
75% corn syrup, 274 cp
85% corn syrup, 561 cp
90% corn syrup, 1000 cp
40
20
0
60
120
180
240
0
300
0
20
40
Time (s)
Fig 5. Xcellerex XDM500: mixing trend 6 g/L for NaCl.
(B)
10
L-glutamine (L-Gln)
9
Component concentration
80
100
Fig 6. Xcellerex XDM200: mixing trend for 1% NaCl in 75%, 85%, and 90% corn syrup.
90
Glucose (g/L)
8
100
(mmol/L)
Component concentration (mmol/L)
(A)
60
Time (min)
7
6
5
4
3
2
1
+
Na (mmol/L)
80
70
60
50
40
30
20
10
0
0
0
60
120
180
Mix time (s)
0
300
240
60
120
180
240
300
Mix time (s)
(C)
(D)
10
400
+
K (mmol/L)
Osmo (mOsm/kg)
350
8
300
7
Osmolarity (mOsm/kg)
Component concentration (mmol/L)
9
6
5
4
3
250
200
150
100
2
50
1
0
0
60
120
180
240
0
300
0
60
Mix time (s)
120
180
240
300
Mix time (s)
Fig 7. Xcellerex XDM500: glucose and l-Gln trends for DMEM/F-12 cell-culture medium (A), sodium trends for DMEM/F-12 (B), potassium trends for DMEM/F-12 (C),
and osmolarity trend for DMEM/F-12 (D).
For local office contact information, visit
www.gelifesciences.com/contact
GE, imagination at work and GE monogram are trademarks of General Electric Company.
Xcellerex is a trademark of Xcellerex, Inc., now part of GE Healthcare.
C-Flex is a trademark of Saint-Gobain Performance Plastics. Kleenpak is a trademark of Pall Corporation.
Thurmalox is a trademark of Dampney Company, Inc.
© 2013 General Electric Company—All rights reserved. First published June 2013.
www.gelifesciences.com/xcellerex
GE Healthcare Bio-Sciences AB
Björkgatan 30
751 84 Uppsala
Sweden
All goods and services are sold subject to the terms and conditions of sale of the company within GE
Healthcare which supplies them. A copy of these terms and conditions is available on request. Contact your
local GE Healthcare representative for the most current information.
GE Healthcare UK Limited
Amersham Place
Little Chalfont
Buckinghamshire, HP7 9NA
UK
GE Healthcare Europe, GmbH
Munzinger Strasse 5
D-79111 Freiburg
Germany
GE Healthcare Bio-Sciences Corp.
800 Centennial Avenue, P.O. Box 1327
Piscataway, NJ 08855-1327
USA
imagination at work
GE Healthcare Japan Corporation
Sanken Bldg., 3-25-1, Hyakunincho
Shinjuku-ku, Tokyo 169-0073
Japan
29-0483-67 AA 06/2013