Material Safety Data Sheet p-Acetophenetidide, 97%

MSDS# 86502

MSDS Name:




Section 1 - Chemical Product and Company Identification p-Acetophenetidide, 97%

AC216590000, AC216590010, AC216590050, AC216591000, AC216592500, AC216595000


Phenacetin; 4'-Ethoxyacetanilide

Company Identification:

Company Identification: (USA)

For information in the US, call:

For information in Europe, call:

Emergency Number, Europe:

Emergency Number US:

CHEMTREC Phone Number, US:

CHEMTREC Phone Number, Europe:

Acros Organics BVBA

Janssen Pharmaceuticalaan 3a

2440 Geel, Belgium

Acros Organics

One Reagent Lane

Fair Lawn, NJ 07410


+32 14 57 52 11

+32 14 57 52 99




Section 2 - Composition, Information on Ingredients



Chemical Name:




Hazard Symbols: T

62-44-2 p-Acetophenetidide



Risk Phrases: 45 22

Section 3 - Hazards Identification


Caution! May cause allergic skin reaction. Cancer suspect agent. May cause central nervous system depression. May cause kidney damage. May cause methemoglobinemia. May cause adverse reproductive effects based upon animal studies. May cause eye and skin irritation. May cause respiratory and digestive tract irritation. May cause cancer in humans. May cause blood abnormalities. Target Organs: Blood, kidneys, central nervous system.

Potential Health Effects



May cause eye irritation.

May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon reexposure to this material. May produce mucosal lesions.

May cause irritation of the digestive tract. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.



Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. May cause sideroblastic anemia and hemolytic anemia. May result in Stevens-Johnson syndrome.

Ingestion of large amounts may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), respiratory depression and cardiac arrest.


May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, tachycardia, dyspnea (labored breathing), and death.

Chronic ingestion may cause effects similar to those of acute ingestion. Chronic exposure may lead to weight loss, shortness of breath, weakness, and often aplastic anemia. Experimental carcinogen.





Section 4 - First Aid Measures

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Notes to


Section 5 - Fire Fighting Measures



As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH

(approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.



In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.



Not available.

Flash Point: Not available

Explosion Limits:



Explosion Limits:



NFPA Rating: health: 1; flammability: 1; instability: 0;

Section 6 - Accidental Release Measures



Use proper personal protective equipment as indicated in Section 8.


Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - Handling and Storage


Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - Exposure Controls, Personal Protection

+-------------------- +------------------- +------------------- +----------------- +

| Chemical Name | ACGIH | NIOSH |OSHA - Final PELs|

|-------------------- |------------------- |------------------- |----------------- |

| p-Acetophenetidide |none listed |none listed |none listed |

+-------------------- +------------------- +------------------- +----------------- +

OSHA Vacated PELs: p-Acetophenetidide: None listed

Engineering Controls:

Use adequate ventilation to keep airborne concentrations low.

Exposure Limits

Personal Protective Equipment


Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.



Wear appropriate protective gloves to prevent skin exposure.

Wear appropriate protective clothing to prevent skin exposure.


Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a

NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Chemical Stability:

Conditions to Avoid:

Incompatibilities with Other Materials

Hazardous Decomposition Products

Hazardous Polymerization

Physical State: Solid

Color: white glistening crystals.

Odor: odorless pH: Not available

Vapor Pressure: < 1 mm Hg @25C

Vapor Density: Not available

Evaporation Rate: Not available

Viscosity: Not available

Boiling Point: Not available

Freezing/Melting Point: 134-135C

Decomposition Temperature: Not available

Solubility in water: 1g/90ml ether - soluble in glycerol

Specific Gravity/Density:

Molecular Formula: C10H13NO2

Molecular Weight: 179.22

Section 10 - Stability and Reactivity

Stable under normal temperatures and pressures.

Incompatible materials, dust generation.

Not available

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen gas.

Has not been reported.

Section 11 - Toxicological Information



CAS# 62-44-2: AM4375000


CAS# 62-44-2:

Inhalation, mouse: LC50 = 33900 mg/m3;

Oral, mouse: LD50 = 866 mg/kg;

Oral, rabbit: LD50 = 2500 mg/kg;


Oral, rat: LD50 = 1650 mg/kg;

Carcinogenicity: p-Acetophenetidide - California: carcinogen, initial date 10/1/89 NTP: Suspect carcinogen IARC: Group

2A carcinogen

Other: See actual entry in RTECS for complete information.

Section 12 - Ecological Information

Not available

Section 13 - Disposal Considerations

Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - Transport Information


Shipping Name: Not regulated as a hazardous material

Hazard Class:

UN Number:

Packing Group:

Canada TDG

Shipping Name: Not available

Hazard Class:

UN Number:

Packing Group:

USA RQ: CAS# 62-44-2: 100 lb final RQ; 45.4 kg final RQ

Section 15 - Regulatory Information

European/International Regulations

European Labeling in Accordance with EC Directives

Hazard Symbols: T

Risk Phrases:

R 45 May cause cancer.

R 22 Harmful if swallowed.

Safety Phrases:

S 53 Avoid exposure - obtain special instructions before use.

S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

WGK (Water Danger/Protection)

CAS# 62-44-2: 1


CAS# 62-44-2 is listed on Canada's DSL List

Canadian WHMIS Classifications: D2A

This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.

CAS# 62-44-2 is not listed on Canada's Ingredient Disclosure List.

US Federal


CAS# 62-44-2 is listed on the TSCA


Section 16 - Other Information

MSDS Creation Date: 10/16/1998

Revision #6 Date 7/20/2009



14:54:49 -05'00'

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantibility or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential, or exemplary damages howsoever arising, even if the company has been advised of the possibility of such damages.