1 CV for Torbjörn Åkerstedt (born 1946) EDUCATION year Degree 1966 High school degree 1970 Master of Science 1979 PhD Institution Solna Läroverk Univ Stockholm Univ of Stockholm (Psychology) ACADEMIC APPOINTMENTS 1970-1973 Instructor in Psychology, Univ Stockholm 1973-1977 Research assistant, Dept Stress Research, Karolinska Institute 1977-1981 Researcher, Dept Stress Research, Karolinska Institute 1981-1988 Associate Professor of Psychophysiology, Dept Stress Res, Karolinska Institute 1981-1988 Laborator (Professor) at National Institute for Psychosocial Factors and Health 1981-1993 Deputy head, Department of Stress Res, Karolinska institute 1988Professor (Psychosocial factors & health), Nat inst Psychosoc Fact Health 1994 Visiting Professor of Medicine - Harvard University (2 months), Faculty of Medicine 1997Adj. Professor of Behavioral Physiology, Karolinska institute 2000Deputy director, Institute of Psychosocial Medicine 2007-2013 Director, Stress Research Institute, Stockholm University 2007-2014 Affiliated Professor, Clinical Neuroscience, Karolinska Institutet 2009Head: Stockholm Stress Center (FAS center) Stocholm Univ & Karolinska Inst 2014Senior Professor, Clinical Neuroscience, Karolinska Institutet OTHER POSITIONS 1979-1983 President Scandinavian Sleep Research Society 1983-1987 Member of the board of the Sleep Research Society (US) 1985Member of the Scientific Committee of the Subcommittee of shift work of the Permanent Commission of the International Association of Occupational Health 1988-1992 Member Scientific Committee European Sleep Research Society 1991-2010 Associate (action) editor of the Journal of Sleep Research 2010Deputy editor of the Journal of Sleep Research 1998Associate (action) editor of Biological Psychology 1992-1996 President European Sleep Research Society 2003-2007 Secretary General of The World Federation of Sleep Research and Sleep Medicine Societies PUBLICATIONS last 5 years Total = 500, of which 275 are found in PubMed and 10% are international reviews Tucker, P., Bejerot, E., Kecklund, G., Aronsson, G. and Akerstedt, T. The impact of work time control on physicians' sleep and well-being. Applied ergonomics, 2015, 47: 109-16. Westerlund, A., Lagerros, Y. T., Kecklund, G., Axelsson, J. and Akerstedt, T. Relationships Between Questionnaire Ratings of Sleep Quality and Polysomnography in Healthy Adults. Behavioral sleep medicine, 2014, 10: 115. Westerlund, A., Brandt, L., Harlid, R., Akerstedt, T. and Lagerros, Y. T. Using the Karolinska Sleep Questionnaire to identify obstructive sleep apnea syndrome in a sleep clinic population. Clin Respir J, 2014, 8: 444-54. Westerlund, A., Bottai, M., Adami, H. O. et al. Habitual sleep patterns and the distribution of body mass index: crosssectional findings among Swedish men and women. Sleep medicine, 2014, 15: 1196-203. Mallon, L., Broman, J. E., Akerstedt, T. and Hetta, J. Insomnia in Sweden: a population-based survey. Sleep Disorder, 2014, 2014: 843126. Magnusson Hanson, L. L., Chungkham, H. S., Akerstedt, T. and Westerlund, H. The Role of Sleep Disturbances in the Longitudinal Relationship Between Psychosocial Working Conditions, Measured by Work Demands and Support, and Depression. Sleep, 2014 Lasselin, J., Rehman, J. U., Akerstedt, T., Lekander, M. and Axelsson, J. Effect of long-term sleep restriction and subsequent recovery sleep on the diurnal rhythms of white blood cell subpopulations. Brain, Behavior and Immunity, 2014 Ingre, M., Van Leeuwen, W., Klemets, T. et al. Validating and extending the three process model of alertness in airline operations. PLoS One, 2014, 9: e108679. Hallvig, D., Anund, A., Fors, C., Kecklund, G. and Akerstedt, T. Real driving at night - Predicting lane departures from physiological and subjective sleepiness. Biol Psychol, 2014, 101: 18-23. Filtness, A. J., Anund, A., Fors, C., Ahlstrom, C., Akerstedt, T. and Kecklund, G. Sleep-related eye symptoms and their potential for identifying driver sleepiness. Journal of sleep research, 2014, 23: 568-75. Bellavia, A., Akerstedt, T., Bottai, M., Wolk, A. and Orsini, N. Sleep duration and survival percentiles across categories of physical activity. American Journal of Epidemiology, 2014, 179: 484-91. 2 Akerstedt, T., Lekander, M., Petersen, H., Kecklund, G. and Axelsson, J. Sleep polysomnography and reported stress across 6 weeks. Industrial health, 2014, 52: 36-42. Akerstedt, T., Axelsson, J., Lekander, M., Orsini, N. and Kecklund, G. Do sleep, stress, and illness explain daily variations in fatigue? A prospective study. Journal of psychosomatic research, 2014, 76: 280-85. Akerstedt, T., Anund, A., Axelsson, J. and Kecklund, G. Subjective sleepiness is a sensitive indicator of insufficient sleep and impaired waking function. Journal of sleep research, 2014, 23: 240-52. Westerlund, A., Bellocco, R., Sundström, J., Adami, H.-O., Åkerstedt, T. and Trolle Lagerros, Y. Sleep characteristics and cardiovascular events in a large Swedish cohort. European journal of epidemiology, 2013: 1-11. Van Leeuwen, W. A., Kircher, A., Dahlgren, A. et al. Sleep, Sleepiness, and Neurobehavioral Performance While on Watch in a Simulated 4 Hours on/8 Hours off Maritime Watch System. Chronobiology international, 2013, 30: 1108-15. Saksvik-Lehouillier, I., Bjorvatn, B., Hetland, H. et al. Individual, situational and lifestyle factors related to shift work tolerance among nurses who are new to and experienced in night work. Journal of Advanced Nursing, 2013, 69: 1136-46. Petersen, H., Kecklund, G., D´Onofrio, P., Nilsson, J. and Åkerstedt, T. Stress vulnerability and the effects of moderate daily stress on sleep polysomnography and subjective sleepiness. Journal of Stress Research, 2013, 22: 5057. Nordin, M., Akerstedt, T. and Nordin, S. Psychometric evaluation and normative data for the Karolinska Sleep Questionnaire. Sleep Biol Rhythms, 2013, 11: 216-26. Lekander, M., Andreasson, A. N., Kecklund, G. et al. Subjective health perception in healthy young men changes in response to experimentally restricted sleep and subsequent recovery sleep. Brain, behavior, and immunity, 2013, 34 Leineweber, C., Kecklund, G., Theorell, T., Åkerstedt, T., Alexanderson, K. and Westerlund, H. Inflytande över arbetstiden och sjuknärvaro/sjukfrånvaro. [Influence over working hours and sickness presenteeism/absence. In Swedish.]. Arbetmarknad & Arbetsliv, 2013, 19: 87-100. Knutsson, A., Alfredsson, L., Karlsson, B. et al. Breast cancer among shift workers: results of the WOLF longitudinal cohort study. Scandinavian Journal of Work, Environment and Health, 2013, 39: 170-77. Jansson, C., Alexanderson, K., Kecklund, G. and Akerstedt, T. Clinically diagnosed insomnia and risk of all-cause and diagnosis-specific disability pension: a nationwide cohort study. Sleep Disorder, 2013: 209832. Jansson, C., Alexanderson, K., Kecklund, G. and Akerstedt, T. Clinically diagnosed insomnia and risk of all-cause and diagnosis-specific sickness absence: A nationwide Swedish prospective cohort study. Scandinavian journal of public health, 2013, 41: 712-21. Ivarsson, M., Anderson, M., Åkerstedt, T. and Lindblad, F. The Effect of Violent and Nonviolent Video Games on Heart Rate Variability, Sleep, and Emotions in Adolescents With Different Violent Gaming Habits. Psychosomatic medicine, 2013, 75: 390-96. Hallvig, D., Anund, A., Fors, C. et al. Sleepy driving on the real road and in the simulator--A comparison. Accident Analysis & Prevention, 2013, 50: 44-50. Flo, E., Pallesen, S., Åkerstedt, T. et al. Shift-related sleep problems vary according to work schedule. Occupational and environmental medicine, 2013, 70: 238-45. Bränström, R., Kvillemo, P. and Åkerstedt, T. Effects of Mindfulness Training on Levels of Cortisol in Cancer Patients. Psychosomatics, 2013, 54: 158-64. Bellavia, A., Akerstedt, T., Bottai, M., Wolk, A. and Orsini, N. Sleep Duration and Survival Percentiles Across Categories of Physical Activity. American Journal of Epidemiology, 2013 Axelsson, J., Rehman, J. U., Akerstedt, T. et al. Effects of sustained sleep restriction on mitogen-stimulated cytokines, chemokines and T helper 1/ T helper 2 balance in humans. PLoS One, 2013, 8: e82291. Åkerstedt, T. and Kecklund, G. Säkerhet, arbetstider och trötthet. In: S. ÖDEGÅRD (Ed), Patientsäkerhet - teori och praktik. Liber, Stockholm, 2013: 399-424. Åkerstedt, T., Hallvig, D., Anund, A., Fors, C., Schwarz, J. and Kecklund, G. Having to stop driving at night because of dangerous sleepiness - awareness, physiology and behaviour. Journal of sleep research, 2013, 22: 380-88. Åkerstedt, T., Axelsson, J., Lekander, M., Orsini, N. and Kecklund, G. The daily variation in sleepiness and its relation to the preceding sleep episode—a prospective study across 42 days of normal living. Journal of sleep research, 2013, 22: 258-65. Åkerstedt, T. Occupational impact (sleep). In: C. KUSHIDA (Ed), Encyclopedia of Sleep. Academic Press, Waltham, MA, 2013: 308-10. Åkerstedt, T. Social and Economic Impact (sleep). In: C. KUSHIDA (Ed), The Encyclopedia of Sleep. Academic Press, Waltham, MA, 2013: 306-07. Åkerstedt, T. Shift work. In: C. KUSHIDA (Ed), The Encyclopedia of Sleep. Academic Press, Waltham, MA, 2013: 197201. Taillard, J., Capelli, A., Sagaspe, P., Anund, A., Akerstedt, T. and Philip, P. In-car nocturnal blue light exposure improves motorway driving: a randomized controlled trial. Public Library of Science, 2012, 7: e46750. 3 Soderstrom, M., Jeding, K., Ekstedt, M., Perski, A. and Akerstedt, T. Insufficient sleep predicts clinical burnout. Journal of Occupational Health Psychology, 2012, 17: 175-83. Schwarz, J. F., Ingre, M., Fors, C. et al. In-car countermeasures open window and music revisited on the real road: popular but hardly effective against driver sleepiness. Journal of sleep research, 2012 Nordin, M., Westerholm, P., Alfredsson, L. and Åkerstedt, T. Social Support and Sleep. Longitudinal Relationships from the WOLF-Study. Psychology, 2012, 3: 1223-30. Lowden, A. and Akerstedt, T. Assessment of a new dynamic light regimen in a nuclear power control room without windows on quickly rotating shiftworkers-effects on health, wakefulness, and circadian alignment: a pilot study. Chronobiology international, 2012, 29: 641-9. Kecklund, G., Milia, L. D., Axelsson, J., Lowden, A. and Akerstedt, T. 20th International Symposium on Shiftwork and Working Time: Biological Mechanisms, Recovery, and Risk Management in the 24-h Society. Chronobiology international, 2012, 29: 531-6. Ingre, M., Akerstedt, T., Ekstedt, M. and Kecklund, G. Periodic self-rostering in shift work: correspondence between objective work hours, work hour preferences (personal fit), and work schedule satisfaction. Scandinavian Journal of Work, Environment and Health, 2012, 38: 327-36. Garde, A. H., Karlson, B., Hansen, Å. M., Persson, R. and Åkerstedt, T. Sleep and Salivary Cortisol. In: M. KRISTENSON, P. GARVIN and U. LUNDBERG (Eds), The Role of Saliva Cortisol Measurement in Health and Disease. Bentham Science Publishers: UAE, 2012: 12. Eckerberg, B., Lowden, A., Nagai, R. and Akerstedt, T. Melatonin treatment effects on adolescent students' sleep timing and sleepiness in a placebo-controlled crossover study. Chronobiology international, 2012, 29: 1239-48. Di Milia, L., Rogers, N. L. and Akerstedt, T. Sleepiness, long distance commuting and night work as predictors of driving performance. PLoS One, 2012, 7 Di Milia, L., Rogers, N. and Åkerstedt, T. Sleepiness, long distance commuting and night work as predictors of driving performance. PLoS One, 2012, 7 Danielsson, M., Heimerson, I., Lundberg, U., Perski, A., Stefansson, C.-G. and Akerstedt, T. Psychosocial stress and health problems. Scandinavian Journal of Public Health (suppl), 2012, 40: 121-34. Bränström, R., Kvillemo, P. and Akerstedt, T. Effects of mindfullness training on levels of cortisol in cancer patients. Psychosomatics, 2012, 54: 158-64. Bonde, J. P., Hansen, K., Kolstad, H. A. et al. Work at night and breast cancer: Report on evidence-based options for preventive actions. Scandinavian Journal of Work Environment & Health, 2012, 38: 380-90. Bonde, J. P., Hansen, J., Kolstad, H. A. et al. Work at night and breast cancer - report on evidence-based options for preventive actions. Scandinavian Journal of Work, Environment and Health, 2012 Åkerstedt, T. and Perski, A. Sleep, Stress and Heart Disease. In: P. HJEMDAHL, A. ROSENGREN and A. STEPTOE (Eds), Stress and Cardiovarscular Disease. Springer Verlag London Ltd, 2012: 257-72. Åkerstedt, T., Orsini, N., Petersen, H., Axelsson, J., Lekander, M. and Kecklund, G. Predicting sleep quality from stress and prior sleep - A study of day-to-day covariation across six weeks. Sleep medicine, 2012, 13: 674-79. Akerstedt, T., Nordin, M., Alfredsson, L., Westerholm, P. and Kecklund, G. Predicting changes in sleep complaints from baseline values and changes in work demands, work control, and work preoccupation--the WOLFproject. Sleep medicine, 2012, 13: 73-80. Akerstedt, T. and Kecklund, G. Sleep, work and occupational stress. In: C. M. MORIN and C. ESPIE (Eds), The Oxford Handbook of Sleep and Sleep Disorders. Oxford University Press, New York, 2012: 248-65. Akerstedt, T., Axelsson, J., Lekander, M., Orsini, N. and Kecklund, G. The daily variation in sleepiness and its relation to the preceding sleep episode-a prospective study across 42 days of normal living. Journal of sleep research, 2012 Sandberg, D., Anund, A., Fors, C. et al. The characteristics of sleepiness during real driving at night--a study of driving performance, physiology and subjective experience. Sleep, 2011, 34: 1317-25. Magnusson Hanson, L. L., Akerstedt, T., Naswall, K., Leineweber, C., Theorell, T. and Westerlund, H. Cross-lagged relationships between workplace demands, control, support and sleep problems. Sleep, 2011, 34: 1403-10. Lowden, A., Akerstedt, T., Ingre, M. et al. Sleep after mobile phone exposure in subjects with mobile phone-related symptoms. Bioelectromagnetics, 2011, 32: 4-14. Hedstrom, A. K., Akerstedt, T., Hillert, J., Olsson, T. and Alfredsson, L. Shift work at young age is associated with increased risk for multiple sclerosis. Annals of Neurology, 2011, 70: 733-41. Hanson, L. L. M., Akerstedt, T., Naswall, K., Leineweber, C., Theorell, T. and Westerlund, H. Cross-Lagged Relationships Between Workplace Demands, Control, Support, and Sleep Problems. Sleep, 2011, 34: 1403U147. Hanson, L. L., Akerstedt, T., Naswall, K., Leineweber, C., Theorell, T. and Westerlund, H. Cross-lagged relationships between workplace demands, control, support, and sleep problems. Sleep, 2011, 34: 1403-10. Dawson, D., Noy, Y. I., Harma, M., Akerstedt, T. and Belenky, G. Modelling fatigue and the use of fatigue models in work settings. Accident Analysis and Prevention, 2011, 43: 549-64. 4 Belenky, G. and Akerstedt, T. Occupational Sleep Medicine, Introduction. In: M. H. KRYGER, T. ROTH and W. C. DEMENT (Eds), Principle and Practice of Sleep Medicine. Elsevier Saunders, St. Louise, MO, 2011: 1723. Anund, A., Ahlstrom, C., Kecklund, G. and Akerstedt, T. Rumble strips in centre of the lane and the effect on sleepy drivers. Industrial health, 2011, 49: 549-58. Åkerstedt, T., Philip, P., Capelli, A. and Kecklund, G. Sleep loss and accident - Work hours, life style, and sleep pathology. Progress in Brain Research, 2011, 190: 169-88. Åkerstedt, T., Perski, A. and Kecklund, G. Sleep, stress and burnout. In: M. H. KRYGER, T. ROTH and W. C. DEMENT (Eds), Principle and Practice of Sleep Medicine. Elsevier Saunders, St. Louise, MO, 2011: 1723. Åkerstedt, T. and Kecklund, G. Shiftwork, severe sleepiness and safety. Industrial health, 2011, 49: 141-42. Vadeby, A., Forsman, A., Kecklund, G., Akerstedt, T., Sandberg, D. and Anund, A. Sleepiness and prediction of driver impairment in simulator studies using a Cox proportional hazard approach. Accident Analysis & Prevention, 2010, 42: 835-41. Tucker, P., Brown, M., Dahlgren, A. et al. The impact of junior doctors' worktime arrangements on their fatigue and well-being. Scandinavian Journal of Work, Environment and Health, 2010, 36: 458-65. Sandberg, D., Akerstedt, T., Anund, A., Kecklund, G. and Wahde, M. Detecting driver sleepiness using optimized nonlinear combinations of sleepiness indicators. IEEE Transactions on Intelligent Transportation Systems, 2010, 12: 97-108. Rehman, J. U., Brismar, K., Holmback, U., Akerstedt, T. and Axelsson, J. Sleeping during the day: effects on the 24-h patterns of IGF-binding protein 1, insulin, glucose, cortisol, and growth hormone. European Journal of Endocrinology, 2010, 163: 383-90. Lowden, A., Akerstedt, T., Ingre, M. et al. Sleep after mobile phone exposure in subjects with mobile phone-related symptoms. Bioelectromagnetics, 2010 Anund, A. and Akerstedt, T. Perception of sleepiness before falling asleep. Sleep medicine, 2010, 11: 743-4. Akerstedt, T., Nordin, M., Alfredsson, L., Westerholm, P. and Kecklund, G. Sleep and sleepiness: impact of entering or leaving shiftwork - a prospective study. Chronobiology international, 2010, 27: 987-96. Akerstedt, T., Kecklund, G. and Selén, J. Early morning work - prevalence and relation to sleep/wake problems: a national representative survey. Chronobiology international, 2010, 27: 975-86. Akerstedt, T., Kecklund, G. and Selen, J. Disturbed sleep and fatigue as predictors of return from long-term sickness absence. Industrial health, 2010, 48: 209-14. Akerstedt, T., Ingre, M., Kecklund, G. et al. Reaction of sleepiness indicators to partial sleep deprivation, time of day and time on task in a driving simulator – the DROWSI project. Journal of sleep research, 2010, 19: 298-309. 5 One major research direction of Dr Akestedt’s has been night work and sleepiness, as evidenced in the first study of sleepiness on the job (in train drivers) and later in other occupational groups (paper workers, truck drivers), as well as experimental studies on sleepiness at the wheel in driving simulators and on the real road. These issues have also been taken into accident epidemiology, showing that night driving results in an increased risk for all types of accidents except those involving overtaking, but particularly single vehicle accidents. Low age was here an unexpected risk factor. In driving simulators also experimental manipulation of time awake and time of day has been used. The interest in sleepiness also led to traditional laboratory experiments on physiological and psychological studies of sleepiness. One of these also led to the development of the Karolinska sleepiness scale (KSS), the most cited work of Dr Åkerstedt. Sleepiness is also presently being investigated in natural and experimental (in progress) infection (using lipopolysacharides) Also sleep (polysomnography) has been a focus in several studies, for example of sleep in shift workers as well as in experimental studies looking at the effect on sleep of a gradual displacement of bedtime across the day.. In epidemiological studies it appears that shift workers do not perceive their sleep as disturbed (although insufficient). Experimental studies have also shown that partial sleep deprivation (4h/night) leads to a gradual increase of SWS. The field and laboratory studies also lead to the development of the three-process model of alertness regulation, inspired by the Borbely model but focusing on the prediction of sleepiness under different work-rest schedules. Most of this work was carried out in collaboration with Dr Simon Folkard. Sleep was also adressed in relation to stress, first demonstrating the dramatic physiological impairment in burnout patients and later as the more modest impairment in healthy individuals on nights with a limited increase in day-to-day stress. Some of this work has also lead to attempts to identify the components of physiological sleep quality. Recently, it was also demonstrated prospectively that, not only does stress impair subsequent sleep but impaired sleep has even stronger effects on the perception of stress. In addition, ongoing research shows that the physiological criteria for good sleep change with age (ongoing) and that good sleep in older individuals compares to poor sleep in younger individuals (in progress). The strong focus on sleep has led to positions as President of the European Sleep Research Society as well as Secretary General of the World Federation of Sleep Research and Sleep Medicine Societies. Outside the sleep area Dr Åkerstedt has also focused on epidemiology of shift work, linking it to multiple sclerosis and to breast cancer as well as stroke and other diseases (ongoing)