BSM 456–001 PATHOGENIC MICROBIOLOGY
Fall 2006
SYLLABUS
Mon, Wed, Fri 8 – 8:50 a.m. 232 Parkinson Hall
Instructor:
Office:
E-mail:
Telephone:
Office hours:
George Pinchuk, M.D., Cand. Sci. Med.
208 Parkinson Hall
gpinchuk@muw.edu
(662) 329-7281 (office), (662) 324-5238 (home)
Mon, Wed 9-11 a.m.; Mon 1-2 p.m.; Wed 1-5 p.m. (Any other time – by
appointment)
WHAT WILL THIS COURSE BE ABOUT?
This senior division-oriented course will concentrate on medical aspects of microbiology.
We will discuss everything that has to do with pathogenic microorganisms and with ways
these microorganisms cause disease in humans.
WHY TAKE THIS COURSE?
I see this course as an important step in the students’ preparation for their further
professional (medical) schooling, or for a career in basic research (graduate school). I
hope it will provide the students with the opportunity to broaden their horizons about the
human disease and the role microorganisms play in it.
DESIRED STUDENT GOALS AND OUTCOMES
At the end of this course, students are expected to be able to: a) know basic facts and
concepts regarding the etiology and pathogenesis of infectious diseases; b) identify - i.e.,
properly name and accurately describe properties of, approximately, 100 most important
infectious agents that cause disease in humans; c) understand basic principles of action
and particular applications of antimicrobial therapeutic agents; d) understand the work of
the human immune system and the principles of immunization against microorganisms;
e) clearly communicate about the applications of microbiology in medicine and
pathology.
TEXTBOOK
Murray, P.R., Rosenthal, K.S., and Pfaller, M.A. Medical Microbiology. Mosby-Elsevier,
2005 (5th edition). 963 pp. ISBN 0-323-03303-2. Available at the university bookstore.
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PREREQUISITES
BSM 240 with lab; BSB 120 or 322.
ATTENDANCE POLICY
Division policy states that any student who misses more than 30% of the classes (in this
case, 20 or more lectures) will receive an F in that course, regardless of their grade at that
time and regardless of the validity of their excuses.
MISSED EXAMS AND LATE ASSIGNMENT
Make-up exams will be given if an acceptable excuse is provided. Any illness must be
appropriately documented by a medical professional. Known conflicts with exams must
be approved prior to the exam date. You will be given an assignment (a written essay)
and a deadline to complete it; if you are late, ten percent of your grade for the assignment
will be deducted unless you provide an acceptable excuse.
STUDENTS WITH DISABILITIES
Every attempt will be made to accommodate students with disabilities. However, it is the
student’s responsibility to notify the instructor of any professionally diagnosed
disabilities so the necessary steps can be taken to meet the student’s learning needs.
METHOD OF EVALUATION
Three semester exams, two unannounced pop quizzes, one comprehensive final exam,
and an essay. See descriptions below. Exam dates are indicated in the lecture plan (see
below). The final grade for the course will be evaluated according to the following
principle:
Total number of points……….
Semester exams……………....
Essay………………………….
Unannounced quizzes………. …
Student Presentations………………
Final exam…………………….
500 pts (100%)
60 pts/exam x 4 = 240 pts
60 pts
25 pts
25 pts
150 pts
If your score of points is 90-100% of the total, you will receive an A; 80-89% - a B, 7079% - a C, 60-69% - a D, 0-59% - an F.
EXAM STRUCTURE AND QUESTION TYPES
There will be two major types of exam questions: one probing your familiarity with terms
and facts, and one testing your understanding of concepts. Questions of the first type may
appear in a multiple choice or in short answer format; of the second type – usually in
short answer format.
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ESSAY
You will be required to write a 7-page (typewritten, double spaced) essay on a topic in
pathogenic microbiology. I am deeply convinced that independently written essays are a
great learning tool. Find some interesting material on the topic that intrigues you, and
summarize your understanding of what you found. Essays should be concise, informative,
and logical. They should trigger a reader’s interest; “infect” him or her with your
enthusiasm about your findings. I will deduct points for sloppy writing or for incorrect
understanding (misinterpretation) of your material. A short list of sources is mandatory. I
may ask you to bring me a copy of a source that you used (to be sure that you did not
plagiarize the material).
STUDENT PRESENTATIONS
We will have three classes entirely dedicated to your presentations. You may present
your essay, or any other interesting topic in pathogenic microbiology (please consult with
me). Present your material in no more than 20 minutes (followed by 5-10 minute
discussion). Use conventional or PowerPoint slides, or the classroom overhead projector
(your choice).
EXTRA CREDIT
None will be given. If you are unhappy with your performance, come see me
immediately, before it is too late. We will work out ways to help you.
IMPORTANT DATES
Fri August 25 – last day to add and/or register for classes
Wed September 20 – last day to drop a course without receiving a grade
Fri September 22 – last day to apply for a degree to be awarded in December
Wed October 18 – last day to drop a course (will receive WP/WF)
Fri November 10 – last day to withdraw from the University
LECTURE AND EXAM PLAN
Note: topics are tentative. We will cover the chapters in the order indicated, but pacewise, we may or may not proceed exactly as indicated. “M” stands for the Murray et al.
textbook (see section “TEXTBOOK” above); Arabic numbers are chapter numbers.
Date
Fri Aug 18
Topic
Introduction. The subject
and a brief history of
pathogenic (medical)
microbiology. Bacterial
classification. General
properties of bacteria
(structure, metabolism,
genetics)
Reading
M 1-5
4
Mon Aug 21
Wed Aug 23
Fri Aug 25
Mon Aug 28
Wed Aug 30
Fri Sep 1
Mon Sep 4
Wed Sep 6
Fri Sep 8
Mon Sep 11
Wed Sep 13
Fri Sep 15
Mon Sep 18
Wed Sep 20
Fri Sep 22
Mon Sep 25
Wed Sep 27
Fri Sep 29
Mon Oct 2
Wed Oct 4
Bacterial classification
(continued). Viral
classification. Fungal and
parasitic classification.
Commensal and pathogenic
microbial flora in humans.
Mechanisms of bacterial
infection. Sterilization,
disinfection, antiseptics.
Antibacterial agents.
Immune response.
Antimicrobial vaccines.
Principles of laboratory
diagnostics.
Review
Exam 1
Staphylococcus,
Streptococcus,
Enterococcus
Bacillus, Listeria,
Erysipelotrix,
Corynebacterium, Nocardia
Mycobacteria
Neisseria
Enterobacteriaceae, Vibrio,
Aeromonas,
Campylobacter,
Helicobacter
Pseudomonas, Hemophilus,
Bordetella, Brucella,
Legionella, Francisella
Review
Exam 2
Anaerobic, Gram-positive,
spore-forming rods.
Anaerobic Gram-positive
non-spore-forming bacteria
Anaerobic Gram-negative
bacteria.
Treponema, Borrelia,
Leptospira
Mycoplasma and
Ureaplasma
Rickettsia and Orientia
Ehrlichia, Anaplasma,
Coxiella
M 6-8
M 9-10, 19, 20
M 11-15
M 16-18, 21
M 1-21
M 1-21
M 22-24
M 25-28
M 29
M 30
M 31-33
M 34-38
M 22-38
M 22-38
M 40-41
M 42
M 43
M 44
M 45
M 46
5
Fri Oct 6
Mon Oct 9
Wed Oct 11
Fri Oct 13
Mon Oct 16
Wed Oct 18
Fri Oct 20
Mon Oct 23
Wed Oct 25
Fri Oct 27
Mon Oct 30
Wed Nov 1
Fri Nov 3
Mon Nov 6
Wed Nov 8
Fri Nov 10
Mon Nov 13
Wed Nov 15
Fri Nov 17
Mon Nov 20
Wed Nov 22
Fri Nov 24
Mon Nov 27
Wed Nov 29
Fri Dec 1
Mon Dec 4
Chlamydiaceae
Fall Break
Role of bacteria in disease
Review
Exam 3
Mechanisms of viral
pathogenesis. Antiviral
agents. Laboratory
diagnosis of viral diseases
Papillomaviruses,
polyomaviruses,
adenoviruses
Herpesviruses, poxviruses,
parvoviruses
Picornaviruses,
coronaviruses, noraviruses
Paramyxoviruses,
orthomyxoviruses
Rhabdoviruses, filoviruses,
bornaviruses, reoviruses
Review
Exam 4
Togaviruses, flaviviruses,
bunyaviruses, arenaviruses,
retroviruses
Hepatitis viruses
Unconventional slow
viruses, viroids, prions
Fungi and antifungal agents.
Laboratory diagnostics of
fungal diseases.
Mycoses
Parasites, antiparasitic
agents. Laboratory
diagnosis of parasitic
diseases
Protozoa, nematodes,
trematodes, cestodes,
arthropods
Student Presentations
Student Presentations
Student Presentations
General Review
General Review
General Review
M 47
M 48
M 40-48
M 40-48
M 49-51
M 52-53
M 54-56
M 57-58
M 59-60
M 61-62
M 49-62
M 49-62
M 63-65
M 66
M 67
M 69-71
M 72-78
M 79-81
M 82-88
All material
All material
All material
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FINAL EXAM: Wednesday, December 6, 8-11 a.m.
ACADEMIC INTEGRITY
In accordance with the University policy and the MUW student honor code, academic
dishonesty will not be tolerated and will result in a grade of 0 for the exam or assignment
in which the dishonesty occurred. In addition, any student who is a party to academic
dishonesty, whether having given or accepted assistance, shall appear before the
Academic Standards Board for appropriate action.
Academic dishonesty includes cheating and plagiarism. While cheating is rather selfexplanatory, plagiarism is not always understood by students correctly. Please keep in
mind that if you copy your essay from some source and then just change a word or two,
it’s still plagiarism.
If you have any questions about what constitutes cheating or plagiarism, please do not
hesitate to ask me.