Product Datasheet
Anti-Claudin 1 antibody ab140349
1 Abreviews
1 Image
Overview
Product name
Anti-Claudin 1 antibody
Description
Rabbit polyclonal to Claudin 1
Tested applications
IHC-P
Species reactivity
Reacts with: Mouse, Rat, Dog, Human, Monkey
Immunogen
Synthetic peptide corresponding to C terminal amino acids of Human Claudin 1.
Positive control
T47D cells, Human skin or breast carcinoma tissue
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage buffer
pH: 7.60
Preservative: 0.09% Sodium azide
Constituents: 99% PBS, 0.2% BSA
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab140349 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
IHC-P
Notes
1/100 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with
IHC staining protocol.
Target
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent
cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells.
Tissue specificity
Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Involvement in disease
Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626];
also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC). NISCH is a rare
autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia,
vulgar type ichthyosis, and sclerosing cholangitis.
Sequence similarities
Belongs to the claudin family.
Cellular localization
Cell junction > tight junction. Cell membrane.
Anti-Claudin 1 antibody images
http://www.abcam.com/Claudin-1-antibody-ab140349.html
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Product Datasheet
Immunohistochemical analysis of paraffin embedded
Human skin labelling Claudin 1 using ab140349 at 1/50
dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffinembedded sections) - Anti-Claudin 1 antibody
(ab140349)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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