Erbitux ™
Erbitux is a targeted therapy classified as a monoclonal antibody.
What Erbitux Is Used For:
 Approved for the treatment of colorectal and head and neck cancers that over-express the
epidermal growth factor receptor “EGFR”.
 It can be given alone or in combination with chemotherapy.
 The first dose takes approximately 2-hours to give, later doses will take about an hour
Erbitux Side Effects:
 Skin irritation, dryness, and cracking
 Rash (acne-like)*
 Low magnesium level
 Diarrhea/Constipation
 Nail disorder - inflammation of the skin surrounding a fingernail or toenail
 Itching
 Headache
*Note: The acne-like rash generally occurs within the first 2-weeks of therapy, and develops
on the face, upper chest, and back (some times, the rash could extends to the arms and legs).
Infusion reactions (chills, fever, shortness of breath, hives, wheezing) have been
experienced with this infusion - rarely, this reaction can be severe with difficulty
breathing, itching, low blood pressure. Pre-medication is given prior to infusion as a
precaution.
Erbitux Precautions:
 Before starting Erbitux treatment, make sure you tell your doctor about any other
medications you are taking (including prescription, over-the-counter, vitamins, herbal
remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor
specifically permits this.
 Do not receive any kind of immunization or vaccination without your doctor's approval
while taking Erbitux.
 For both men and women: Do not conceive a child (get pregnant) while taking Erbitux.
Barrier methods of contraception, such as condoms, are recommended. Discuss with your
doctor when you may safely become pregnant or conceive a child after therapy.
(birth control must be used for 6-months after the last dose of Erbitux)
Erbitux Self Care Tips:
 Drink at least two to three quarts of fluid every 24 hours, unless you are instructed
otherwise.
 An acne-like rash is a common side effect of Erbitux. If you are experiencing this side
effect make sure your health care professional is aware, so they can assess the severity
and offer suggestions for management.
 Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.
 In general, drinking alcoholic beverages should be kept to a minimum or avoided
completely. You should discuss this with your doctor.
 Get plenty of rest.
 Maintain good nutrition.
 If you experience symptoms or side effects, be sure to discuss them with your health care
team. They can prescribe medications and/or offer other suggestions that are effective in
managing such problems.
 Apply lotions, creams, or moisturizers to help with dry skin.
 Cool compresses may help relieve itching.
 If you develop diarrhea, talk to your doctor or nurse about your symptoms; stay hydrated
by drinking plenty of fluids.